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UBE4A Gene

protein-coding   GIFtS: 60
GCID: GC11P118264

Ubiquitination Factor E4A

(Previous names: ubiquitination factor E4A (homologous to yeast UFD2), ubiquitination...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitination Factor E4A1 2     Ubiquitination Factor E4A (Homologous To Yeast UFD2)1
Ubiquitination Factor E4A (UFD2 Homolog, Yeast)1 2     UBOX22
E42 5     Ubiquitin Conjugation Factor E4 A2
UFD22 5     KIAA01263

External Ids:    HGNC: 124991   Entrez Gene: 93542   Ensembl: ENSG000001103447   OMIM: 6037535   UniProtKB: Q141393   

Export aliases for UBE4A gene to outside databases

Previous GC identifers: GC11P120587 GC11P119742 GC11P117767 GC11P117735 GC11P114164


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE4A Gene:
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin
chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination
of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A
pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for UBE4A Gene:
UBE4A (ubiquitination factor E4A) is a protein-coding gene. Diseases associated with UBE4A include serous cystadenocarcinoma, and ovarian serous cystadenocarcinoma. GO annotations related to this gene include ubiquitin-ubiquitin ligase activity. An important paralog of this gene is UBE4B.

UniProtKB/Swiss-Prot: UBE4A_HUMAN, Q14139
Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in
conjunction with E1, E2, and E3 (By similarity)

Gene Wiki entry for UBE4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE4A gene promoter:
         TBP   NF-1/L   RP58   NF-1   RFX1   ATF-2   POU3F2   GATA-1   FOXO4   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE4A promoter sequence
   Search Chromatin IP Primers for UBE4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

UBE4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE4A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118264:  view genomic region     (about GC identifiers)

Start:
118,230,296 bp from pter      End:
118,269,926 bp from pter
Size:
39,631 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBE4A_HUMAN, Q14139 (See protein sequence)
Recommended Name: Ubiquitin conjugation factor E4 A  
Size: 1066 amino acids; 122561 Da
Sequence caution: Sequence=AAH52643.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH62695.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA09475.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for UBE4A:
1WGM (3D)    
Secondary accessions: B0YJB6 Q2M1H0 Q6P5T4 Q7Z639
Alternative splicing: 2 isoforms:  Q14139-1   Q14139-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE4A: NX_Q14139

Explore proteomics data for UBE4A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys104, Lys468, Lys531, Lys679, Lys741, Lys766, Lys774
  • Modification sites at PhosphoSitePlus

  • See UBE4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001191006.1  NP_004779.2  

    ENSEMBL proteins: 
     ENSP00000252108   ENSP00000387362   ENSP00000438918  
    Reactome Protein details: Q14139

    UBE4A Human Recombinant Protein Products:

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    Browse Kits and Assays available from EMD Millipore
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBOX: U-box domain containing

    3 InterPro protein domains:
     IPR003613 Ubox_domain
     IPR019474 Ub_conjug_fac_E4_core
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q14139

    ProtoNet protein and cluster: Q14139

    1 Blocks protein domain: IPB003613 Zn-finger

    UniProtKB/Swiss-Prot: UBE4A_HUMAN, Q14139
    Similarity: Belongs to the ubiquitin conjugation factor E4 family
    Similarity: Contains 1 U-box domain


    UBE4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE4A_HUMAN, Q14139
    Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in
    conjunction with E1, E2, and E3 (By similarity)

         Genatlas biochemistry entry for UBE4A:
    ubiquitination factor E4A,homologous to yeast UFD2,expressed in brain,required for multiubiquitin chain
    assembly,in association with E1,E2,E3,related to Drosophila NOSA

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ----
    GO:0005515protein binding IPI--
    GO:0034450ubiquitin-ubiquitin ligase activity IEA--
         
    UBE4A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for UBE4A:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Increased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE4A
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE4A

    miRNA
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    miRTarBase miRNAs that target UBE4A:
    hsa-mir-16-5p (MIRT001399), hsa-mir-17-5p (MIRT050796)

    Block miRNA regulation of human, mouse, rat UBE4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE4A (see all 58):
    hsa-miR-548j hsa-miR-4291 hsa-miR-142-5p hsa-miR-4254 hsa-miR-300 hsa-miR-1197 hsa-miR-15a hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidUBE4A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE4A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): UBE4A (NM_004788)
    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE4A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IEA--
    GO:0005737cytoplasm IEA--

    UBE4A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE4A About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for UBE4A
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for UBE4A):
        Ubiquitin mediated proteolysis


    UBE4A for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE4A: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBE4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE4A (Q141391, 3 ENSP000002521084) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAVSQ7Z4341, 3, ENSP000004019804EBI-1048119,EBI-995373 I2D: score=1 STRING: ENSP00000401980
    PTP4A3O753653, ENSP000003322744I2D: score=2 STRING: ENSP00000332274
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016567protein ubiquitination ----

    UBE4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE4A

    4 HMDB Compounds for UBE4A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBE4A gene (2 alternative transcripts): 
    NM_001204077.1  NM_004788.3  

    Unigene Cluster for UBE4A:

    Ubiquitination factor E4A
    Hs.75275  [show with all ESTs]
    Unigene Representative Sequence: NM_004788
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252108(uc001psw.3 uc001psv.3) ENST00000431736 ENST00000545354

    miRNA
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    Block miRNA regulation of human, mouse, rat UBE4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE4A (see all 58):
    hsa-miR-548j hsa-miR-4291 hsa-miR-142-5p hsa-miR-4254 hsa-miR-300 hsa-miR-1197 hsa-miR-15a hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidUBE4A 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE4A
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): UBE4A (NM_004788)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE4A
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      QuantiTect SYBR Green Assays in human, mouse, rat UBE4A
      QuantiFast Probe-based Assays in human, mouse, rat UBE4A

    Additional mRNA sequence: 

    AF087968.1 AK296369.1 AK302328.1 AK307737.1 BC010938.1 BC030973.1 BC039240.1 BC052643.1 
    BC062695.1 BC111417.1 BC112367.1 D50916.1 

    17 DOTS entries:

    DT.101983809  DT.101966714  DT.95219286  DT.95228417  DT.92439681  DT.317845  DT.120693753  DT.40115731 
    DT.101965579  DT.92439683  DT.95292093  DT.100744038  DT.100792366  DT.40314850  DT.91685705  DT.100645178 
    DT.92439680 

    Selected AceView cDNA sequences (see all 1072):

    BM459735 AA478793 CF127155 F18594 AA127335 BM840231 BM914781 AI219595 
    BI825461 AW328279 AA687825 BU542659 AA768483 N70368 BX495755 AA046297 
    AI129650 AI707661 BG180959 AI144014 AA424830 BF982807 CB242044 AW629044 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBE4A (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^
    SP1:                    -                                                           -                                                                       -   
    SP2:                    -                                   -                       -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21
    SP1:              -               
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for UBE4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGAGGCTG
    UBE4A Expression
    About this image

    UBE4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75275
        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE4A: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UBE4A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE4A
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    QuantiFast Probe-based Assays in human, mouse, rat UBE4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE4A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube4a1 , 5 ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)5
    ubiquitination factor E4A1
    92.09(n)1
    97.18(a)1
      9 (24.84 cM)5
    1406301  NM_145400.31  NP_663375.31 
     449231315 
    chicken
    (Gallus gallus)
    Aves UBE4A1 ubiquitination factor E4A 79.61(n)
    88.27(a)
      419758  NM_001030910.1  NP_001026081.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE4A6
    ubiquitination factor E4A
    85(a)
    1 ↔ 1
    GL343767.1(82830-94841)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ041478.12   -- 75.9(n)    BJ041478.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube4a1 ubiquitination factor E4A (UFD2 homolog, yeast) 70.64(n)
    77.75(a)
      557121  XM_001922926.4  XP_001922961.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD344753
    CG110701
    ubiquitin-dependent protein catabolism3
    CG110701
    34(a)3
    49.98(n)1
    39(a)1
      339321  NM_135216.31  NP_609060.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UFD26
    Ubiquitin chain assembly factor (E4) that cooperat...
    23(a)
    1 → many
    IV(118707-121592) YDL190C


    ENSEMBL Gene Tree for UBE4A (if available)
    TreeFam Gene Tree for UBE4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE4A gene
    UBE4B2  

    UBE4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE4A (see all 480)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480351001,2
    --118228618(+) GGCTCA/GTTTCA 2 -- us2k10--------
    rs71101971,2
    C,F,A,H--118228624(+) tttcaG/Cttagc 2 -- us2k112Minor allele frequency- C:0.31NS EA NA WA 788
    rs1417853881,2
    --118228630(+) TTAGCA/GTAACG 2 -- us2k10--------
    rs755620931,2
    C--118228723(+) CATATT/GTTGTT 2 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1899489031,2
    --118228729(+) TTGTTC/TATGCA 2 -- us2k10--------
    rs1505998821,2
    --118228862(+) AAAGCA/GGAATT 2 -- us2k10--------
    rs1395021591,2
    --118228904(+) TTTTGA/GGGAAT 2 -- us2k10--------
    rs454893941,2
    C,F--118228968(+) GCATAC/GGGTTT 2 -- us2k110Minor allele frequency- G:0.31NS NA WA EA 400
    rs1427473241,2
    C--118229006(+) TTTCC-/TTTTTT 2 -- us2k10--------
    rs358659491,2
    C,F--118229061(+) TTTTTT/ATTTTC 2 -- us2k18Minor allele frequency- A:0.29NS NA WA EA 384

    HapMap Linkage Disequilibrium report for UBE4A (118230296 - 118269926 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UBE4A: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE4A
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603753    OMIM disorders: --

    9 diseases for UBE4A:    
    About MalaCards
    serous cystadenocarcinoma    ovarian serous cystadenocarcinoma    cystadenocarcinoma    scleroderma
    crohn's disease    conjunctivitis    inflammatory bowel disease    neuroblastoma
    malaria

    1 disease from the University of Copenhagen DISEASES database for UBE4A:
    Ovarian serous cystadenocarcinoma

    UBE4A for disorders           About GeneDecksing


    Export disorders for UBE4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE4A gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with UBE4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    3. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. (PubMed id 10089879)1, 3 Koegl M....Jentsch S. (Cell 1999)
    4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T.... Nomura N. (DNA Res. 1995)
    5. Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues. (PubMed id 15019985)1, 9 Contino G....Novelli G. (Gene 2004)
    6. Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. (PubMed id 18069675)1, 9 Sakiyama T....Tsubouchi H. (Inflamm. Bowel Dis. 2008)
    7. [Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues]. (PubMed id 17553343)1, 9 Yang Y....Yang H.J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007)
    8. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S.... Dorf M.E. (Immunity 2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9354 HGNC: 12499 AceView: UBE4AandATP5L Ensembl:ENSG00000110344 euGenes: HUgn9354
    ECgene: UBE4A Kegg: 9354 H-InvDB: UBE4A

    (According to HUGE)
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    HUGE: KIAA0126

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE4A gene:
    Search GeneIP for patents involving UBE4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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