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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE4A Gene

protein-coding   GIFtS: 61
GCID: GC11P118264

Ubiquitination Factor E4A

(Previous names: ubiquitination factor E4A (homologous to yeast UFD2), ubiquitination...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitination Factor E4A1 2     Ubiquitination Factor E4A (Homologous To Yeast UFD2)1
Ubiquitination Factor E4A (UFD2 Homolog, Yeast)1 2     UBOX22
E42 5     Ubiquitin Conjugation Factor E4 A2
UFD22 5     KIAA01263

External Ids:    HGNC: 124991   Entrez Gene: 93542   Ensembl: ENSG000001103447   OMIM: 6037535   UniProtKB: Q141393   

Export aliases for UBE4A gene to outside databases

Previous GC identifers: GC11P120587 GC11P119742 GC11P117767 GC11P117735 GC11P114164


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE4A Gene:
This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin
chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination
of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A
pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants
encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Feb 2011)

GeneCards Summary for UBE4A Gene: 
UBE4A (ubiquitination factor E4A) is a protein-coding gene. Diseases associated with UBE4A include scleroderma, and crohn's disease, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include protein binding and ubiquitin-ubiquitin ligase activity. An important paralog of this gene is UBE4B.

UniProtKB/Swiss-Prot: UBE4A_HUMAN, Q14139
Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in
conjunction with E1, E2, and E3 (By similarity)

Gene Wiki entry for UBE4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE4A gene promoter:
         TBP   NF-1/L   RP58   NF-1   RFX1   ATF-2   POU3F2   GATA-1   FOXO4   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE4A promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

UBE4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE4A gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P118264:  view genomic region     (about GC identifiers)

Start:
118,230,296 bp from pter      End:
118,269,926 bp from pter
Size:
39,631 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBE4A_HUMAN, Q14139 (See protein sequence)
Recommended Name: Ubiquitin conjugation factor E4 A  
Size: 1066 amino acids; 122561 Da
Sequence caution: Sequence=AAH52643.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH62695.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA09475.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for UBE4A:
1WGM (3D)    
Secondary accessions: B0YJB6 Q2M1H0 Q6P5T4 Q7Z639
Alternative splicing: 2 isoforms:  Q14139-1   Q14139-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE4A: NX_Q14139

Explore proteomics data for UBE4A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q14139

  • UBE4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE4A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001191006.1  NP_004779.2  

    ENSEMBL proteins: 
     ENSP00000252108   ENSP00000387362   ENSP00000438918  
    Reactome Protein details: Q14139
    Human Recombinant Protein Products for UBE4A: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IEA--
    GO:0005737cytoplasm IEA--

    UBE4A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBOX: U-box domain containing

    3 InterPro protein domains:
     IPR003613 Ubox_domain
     IPR019474 Ub_conjug_fac_E4_core
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q14139

    ProtoNet protein and cluster: Q14139

    1 Blocks protein domain: IPB003613 Zn-finger

    UniProtKB/Swiss-Prot: UBE4A_HUMAN, Q14139
    Similarity: Belongs to the ubiquitin conjugation factor E4 family
    Similarity: Contains 1 U-box domain


    UBE4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE4A_HUMAN, Q14139
    Function: Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in
    conjunction with E1, E2, and E3 (By similarity)

         Genatlas biochemistry entry for UBE4A:
    ubiquitination factor E4A,homologous to yeast UFD2,expressed in brain,required for multiubiquitin chain
    assembly,in association with E1,E2,E3,related to Drosophila NOSA

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ----
    GO:0005515protein binding IPI--
    GO:0034450ubiquitin-ubiquitin ligase activity IEA--
         
    UBE4A for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for UBE4A:
     Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content  Increased cilium length after  

    Animal Models:
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    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE4A (see all 58):
    hsa-miR-548j hsa-miR-4291 hsa-miR-142-5p hsa-miR-4254 hsa-miR-300 hsa-miR-1197 hsa-miR-15a hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidUBE4A 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE4A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE4A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for UBE4A
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE4A):
        Ubiquitin mediated proteolysis


    UBE4A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for UBE4A (Q141391, 3 ENSP000002521084) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAVSQ7Z4341, 3, ENSP000004019804EBI-1048119,EBI-995373 I2D: score=1 STRING: ENSP00000401980
    PTP4A3O753653, ENSP000003322744I2D: score=2 STRING: ENSP00000332274
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    VCPP550723, ENSP000003517774I2D: score=1 STRING: ENSP00000351777
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IEA--
    GO:0006511ubiquitin-dependent protein catabolic process IEA--
    GO:0016567protein ubiquitination ----

    UBE4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE4A

    4 HMDB Compounds for UBE4A    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE4A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE4A gene (2 alternative transcripts): 
    NM_001204077.1  NM_004788.3  

    Unigene Cluster for UBE4A:

    Ubiquitination factor E4A
    Hs.75275  [show with all ESTs]
    Unigene Representative Sequence: NM_004788
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000252108(uc001psw.3 uc001psv.3) ENST00000431736 ENST00000545354

    miRNA
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    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE4A (see all 58):
    hsa-miR-548j hsa-miR-4291 hsa-miR-142-5p hsa-miR-4254 hsa-miR-300 hsa-miR-1197 hsa-miR-15a hsa-miR-513a-5p
    SwitchGear 3'UTR luciferase reporter plasmidUBE4A 3' UTR sequence
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    Additional mRNA sequence: 

    AF087968.1 AK296369.1 AK302328.1 AK307737.1 BC010938.1 BC030973.1 BC039240.1 BC052643.1 
    BC062695.1 BC111417.1 BC112367.1 D50916.1 

    17 DOTS entries:

    DT.101983809  DT.101966714  DT.95219286  DT.95228417  DT.92439681  DT.317845  DT.120693753  DT.40115731 
    DT.101965579  DT.92439683  DT.95292093  DT.100744038  DT.100792366  DT.40314850  DT.91685705  DT.100645178 
    DT.92439680 

    24/1072 AceView cDNA sequences (see all 1072):

    AW162589 AA812656 AI148038 AA810789 BG741723 CD108207 BG742105 AA341568 
    AA278832 AI027525 BF593115 AW170767 AA385776 AW992386 BU956574 CD679088 
    BG026211 AA953153 AL050277 BP356288 AI343302 BE394339 AI815226 AI580795 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBE4A (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^
    SP1:                    -                                                           -                                                                       -   
    SP2:                    -                                   -                       -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18 ^ 19 ^ 20a · 20b ^ 21
    SP1:              -               
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for UBE4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGAGGCTG
    UBE4A Expression
    About this image


    See UBE4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE4A

    SOURCE GeneReport for Unigene cluster: Hs.75275
        SABiosciences Expression via Pathway-Focused PCR Arrays including UBE4A: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE4A gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube4a1 , 5 ubiquitination factor E4A, UFD2 homolog (S. cerevisiae)1, 5 92.09(n)1
    97.18(a)1
      9 (24.84 cM)5
    1406301  NM_145400.31  NP_663375.31 
     449231315 
    chicken
    (Gallus gallus)
    Aves UBE4A1 ubiquitination factor E4A 79.64(n)
    88.27(a)
      419758  NM_001030910.1  NP_001026081.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE4A6
    Uncharacterized protein
    85(a)
    1 ↔ 1
    GL343767.1(82830-94841)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ041478.12   -- 75.9(n)    BJ041478.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube4a1 ubiquitination factor E4A (UFD2 homolog, yeast) 70.64(n)
    77.75(a)
      557121  XM_001922926.3  XP_001922961.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:LD344753
    CG110701
    ubiquitin-dependent protein catabolism3
    CG110701
    34(a)3
    49.91(n)1
    38.96(a)1
      339321  NM_135216.31  NP_609060.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UFD26
    Ubiquitin chain assembly factor (E4) that cooperat...
    20(a)
    1 → many
    IV(118707-121592)


    ENSEMBL Gene Tree for UBE4A (if available)
    TreeFam Gene Tree for UBE4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE4A gene
    UBE4B2  
    1 SIMAP similar gene for UBE4A using alignment to 4 protein entries:     UBE4A_HUMAN (see all proteins):
    Ube4B

    UBE4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/480 SNPs in UBE4A are shown (see all 480)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1480351001,2
    --118228618(+) GGCTCA/GTTTCA 2 -- us2k10--------
    rs71101971,2
    C,F,A,H--118228624(+) tttcaG/Cttagc 2 -- us2k112Minor allele frequency- C:0.31NS EA NA WA 788
    rs1417853881,2
    --118228630(+) TTAGCA/GTAACG 2 -- us2k10--------
    rs755620931,2
    C--118228723(+) CATATT/GTTGTT 2 -- us2k12Minor allele frequency- G:0.06WA 120
    rs1899489031,2
    --118228729(+) TTGTTC/TATGCA 2 -- us2k10--------
    rs1505998821,2
    --118228862(+) AAAGCA/GGAATT 2 -- us2k10--------
    rs1395021591,2
    --118228904(+) TTTTGA/GGGAAT 2 -- us2k10--------
    rs454893941,2
    C,F--118228968(+) GCATAC/GGGTTT 2 -- us2k110Minor allele frequency- G:0.31NS NA WA EA 400
    rs1427473241,2
    C--118229006(+) TTTCC-/TTTTTT 2 -- us2k10--------
    rs358659491,2
    C,F--118229061(+) TTTTTT/ATTTTC 2 -- us2k18Minor allele frequency- A:0.29NS NA WA EA 384

    HapMap Linkage Disequilibrium report for UBE4A (118230296 - 118269926 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UBE4A: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE4A
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603753    OMIM disorders: --

    8 diseases for UBE4A:    About MalaCards
    scleroderma    crohn's disease    cystadenocarcinoma    ovarian serous cystadenocarcinoma
    serous cystadenocarcinoma    conjunctivitis    inflammatory bowel disease    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for UBE4A:
    Ovarian serous cystadenocarcinoma

    UBE4A for disorders           About GeneDecksing


    Export disorders for UBE4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE4A gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with UBE4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    3. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. (PubMed id 10089879)1, 3 Koegl M....Jentsch S. (1999)
    4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
    5. Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues. (PubMed id 15019985)1, 9 Contino G....Novelli G. (2004)
    6. Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. (PubMed id 18069675)1, 9 Sakiyama T....Tsubouchi H. (2008)
    7. [Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues] (PubMed id 17553343)1, 9 Yang Y....Yang H.J. (2007)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9354 HGNC: 12499 AceView: UBE4AandATP5L Ensembl:ENSG00000110344 euGenes: HUgn9354
    ECgene: UBE4A Kegg: 9354 H-InvDB: UBE4A

    (According to HUGE)
    About This Section
    HUGE: KIAA0126

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE4A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE4A gene:
    Search GeneIP for patents involving UBE4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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