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Aliases for UBE4A Gene

Aliases for UBE4A Gene

  • Ubiquitination Factor E4A 2 3
  • Ubiquitination Factor E4A (UFD2 Homolog, Yeast) 2 3
  • Ubiquitination Factor E4A (Homologous To Yeast UFD2) 2
  • EC 6.3.2.- 4
  • KIAA0126 4
  • UBOX2 3
  • UFD2 3
  • E4 3

External Ids for UBE4A Gene

Previous GeneCards Identifiers for UBE4A Gene

  • GC11P120587
  • GC11P119742
  • GC11P118264
  • GC11P117767
  • GC11P117735
  • GC11P114164

Summaries for UBE4A Gene

Entrez Gene Summary for UBE4A Gene

  • This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for UBE4A Gene

UBE4A (Ubiquitination Factor E4A) is a Protein Coding gene. Diseases associated with UBE4A include ovary serous adenocarcinoma and ovarian cystadenocarcinoma. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin-ubiquitin ligase activity. An important paralog of this gene is UBE4B.

UniProtKB/Swiss-Prot for UBE4A Gene

  • Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates Lys-48-linked polyubiquitination of substrates.

Gene Wiki entry for UBE4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE4A Gene

Genomics for UBE4A Gene

Regulatory Elements for UBE4A Gene

Genomic Location for UBE4A Gene

Chromosome:
11
Start:
118,359,581 bp from pter
End:
118,399,211 bp from pter
Size:
39,631 bases
Orientation:
Plus strand

Genomic View for UBE4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE4A Gene

Proteins for UBE4A Gene

  • Protein details for UBE4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14139-UBE4A_HUMAN
    Recommended name:
    Ubiquitin conjugation factor E4 A
    Protein Accession:
    Q14139
    Secondary Accessions:
    • B0YJB6
    • Q2M1H0
    • Q6P5T4
    • Q7Z639

    Protein attributes for UBE4A Gene

    Size:
    1066 amino acids
    Molecular mass:
    122561 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH52643.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62695.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA09475.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE4A Gene

    Alternative splice isoforms for UBE4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE4A Gene

Proteomics data for UBE4A Gene at MOPED

Post-translational modifications for UBE4A Gene

  • Ubiquitination at Lys 104, Lys 468, Lys 531, Lys 679, Lys 741, Lys 766, and Lys 774
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE4A Gene

Antibody Products

No data available for DME Specific Peptides for UBE4A Gene

Domains & Families for UBE4A Gene

Gene Families for UBE4A Gene

Protein Domains for UBE4A Gene

Graphical View of Domain Structure for InterPro Entry

Q14139

UniProtKB/Swiss-Prot:

UBE4A_HUMAN :
  • The U-box domain is required for the ubiquitin protein ligase activity.
  • Belongs to the ubiquitin conjugation factor E4 family.
Domain:
  • The U-box domain is required for the ubiquitin protein ligase activity.
  • Contains 1 U-box domain.
Family:
  • Belongs to the ubiquitin conjugation factor E4 family.
genes like me logo Genes that share domains with UBE4A: view

Function for UBE4A Gene

Molecular function for UBE4A Gene

GENATLAS Biochemistry:
ubiquitination factor E4A,homologous to yeast UFD2,expressed in brain,required for multiubiquitin chain assembly,in association with E1,E2,E3,related to Drosophila NOSA
UniProtKB/Swiss-Prot Function:
Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates Lys-48-linked polyubiquitination of substrates.

Enzyme Numbers (IUBMB) for UBE4A Gene

Gene Ontology (GO) - Molecular Function for UBE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 21903422
GO:0016874 ligase activity IEA --
GO:0034450 ubiquitin-ubiquitin ligase activity IEA --
GO:0061630 ubiquitin protein ligase activity --
genes like me logo Genes that share ontologies with UBE4A: view
genes like me logo Genes that share phenotypes with UBE4A: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE4A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UBE4A Gene

Localization for UBE4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE4A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE4A Gene COMPARTMENTS Subcellular localization image for UBE4A gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for UBE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBE4A: view

Pathways & Interactions for UBE4A Gene

genes like me logo Genes that share pathways with UBE4A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat

UniProtKB/Swiss-Prot Q14139-UBE4A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016567 protein ubiquitination --
genes like me logo Genes that share ontologies with UBE4A: view

No data available for SIGNOR curated interactions for UBE4A Gene

Drugs & Compounds for UBE4A Gene

(3) Drugs for UBE4A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE4A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE4A: view

Transcripts for UBE4A Gene

mRNA/cDNA for UBE4A Gene

Unigene Clusters for UBE4A Gene

Ubiquitination factor E4A:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE4A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for UBE4A Gene

GeneLoc Exon Structure for
UBE4A
ECgene alternative splicing isoforms for
UBE4A

Expression for UBE4A Gene

mRNA expression in normal human tissues for UBE4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE4A Gene

This gene is overexpressed in Bone (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE4A Gene



SOURCE GeneReport for Unigene cluster for UBE4A Gene Hs.75275

genes like me logo Genes that share expression patterns with UBE4A: view

Protein tissue co-expression partners for UBE4A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE4A Gene

Orthologs for UBE4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE4A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE4A 35
  • 93.43 (n)
  • 96.9 (a)
UBE4A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE4A 35
  • 95.06 (n)
  • 98.59 (a)
UBE4A 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube4a 35
  • 92.09 (n)
  • 97.18 (a)
Ube4a 16
Ube4a 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE4A 35
  • 99.75 (n)
  • 99.72 (a)
UBE4A 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube4a 35
  • 91.59 (n)
  • 96.9 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE4A 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE4A 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE4A 35
  • 79.61 (n)
  • 88.27 (a)
UBE4A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE4A 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube4a 35
  • 71.18 (n)
  • 78.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ube4a 35
  • 70.64 (n)
  • 77.75 (a)
ube4a 36
  • 77 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD34475 37
  • 34 (a)
CG11070 35
  • 49.98 (n)
  • 39 (a)
CG11070 36
  • 35 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001681 35
  • 48.62 (n)
  • 39.79 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UFD2 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for UBE4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE4A Gene

ENSEMBL:
Gene Tree for UBE4A (if available)
TreeFam:
Gene Tree for UBE4A (if available)

Paralogs for UBE4A Gene

Paralogs for UBE4A Gene

genes like me logo Genes that share paralogs with UBE4A: view

Variants for UBE4A Gene

Sequence variations from dbSNP and Humsavar for UBE4A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs502514 -- 118,371,280(+) cctac(C/T)ctatg intron-variant
rs531396 -- 118,359,611(-) CACTT(C/T)CGACT utr-variant-5-prime
rs558187 -- 118,369,804(-) GGCTT(G/T)GTAAT intron-variant
rs563584 -- 118,364,391(-) AATGG(G/T)CTTTG intron-variant
rs1621896 -- 118,369,673(-) GCCTT(C/T)TACTG intron-variant

Variation tolerance for UBE4A Gene

Residual Variation Intolerance Score: 17.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.07; 37.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE4A Gene

HapMap Linkage Disequilibrium report
UBE4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UBE4A Gene

Disorders for UBE4A Gene

MalaCards: The human disease database

(4) MalaCards diseases for UBE4A Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
ovarian cystadenocarcinoma
  • cystadenocarcinoma of the ovary
crohn's disease
  • enteritis
scleroderma
  • dermatosclerosis
- elite association
Search UBE4A in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBE4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE4A
genes like me logo Genes that share disorders with UBE4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE4A Gene

Publications for UBE4A Gene

  1. New serological biomarkers of inflammatory bowel disease. (PMID: 18777587) Li X. … Alex P. (World J. Gastroenterol. 2008) 23 67
  2. Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. (PMID: 18069675) Sakiyama T. … Tsubouchi H. (Inflamm. Bowel Dis. 2008) 23 67
  3. [Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues]. (PMID: 17553343) Yang Y. … Yang H.J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007) 23 67
  4. The two human homologues of yeast UFD2 ubiquitination factor, UBE4A and UBE4B, are located in common neuroblastoma deletion regions and are subject to mutations in tumours. (PMID: 16386891) CarAcn H. … Martinsson T. (Eur. J. Cancer 2006) 23 67
  5. Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues. (PMID: 15019985) Contino G. … Novelli G. (Gene 2004) 23 67

Products for UBE4A Gene

Sources for UBE4A Gene

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