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Aliases for UBE4A Gene

Aliases for UBE4A Gene

  • Ubiquitination Factor E4A 2 3
  • Ubiquitination Factor E4A (UFD2 Homolog, Yeast) 2 3
  • UFD2 3 6
  • E4 3 6
  • Ubiquitination Factor E4A (Homologous To Yeast UFD2) 2
  • Ubiquitin Conjugation Factor E4 A 3
  • EC 6.3.2.- 4
  • KIAA0126 4
  • UBOX2 3

External Ids for UBE4A Gene

Previous GeneCards Identifiers for UBE4A Gene

  • GC11P120587
  • GC11P119742
  • GC11P118264
  • GC11P117767
  • GC11P117735
  • GC11P114164

Summaries for UBE4A Gene

Entrez Gene Summary for UBE4A Gene

  • This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for UBE4A Gene

UBE4A (Ubiquitination Factor E4A) is a Protein Coding gene. Diseases associated with UBE4A include ovarian serous cystadenocarcinoma and serous cystadenocarcinoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-ubiquitin ligase activity. An important paralog of this gene is UBE4B.

UniProtKB/Swiss-Prot for UBE4A Gene

  • Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates Lys-48-linked polyubiquitination of substrates.

Gene Wiki entry for UBE4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE4A Gene

Genomics for UBE4A Gene

Regulatory Elements for UBE4A Gene

Genomic Location for UBE4A Gene

Start:
118,359,581 bp from pter
End:
118,399,211 bp from pter
Size:
39,631 bases
Orientation:
Plus strand

Genomic View for UBE4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE4A Gene

Proteins for UBE4A Gene

  • Protein details for UBE4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14139-UBE4A_HUMAN
    Recommended name:
    Ubiquitin conjugation factor E4 A
    Protein Accession:
    Q14139
    Secondary Accessions:
    • B0YJB6
    • Q2M1H0
    • Q6P5T4
    • Q7Z639

    Protein attributes for UBE4A Gene

    Size:
    1066 amino acids
    Molecular mass:
    122561 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH52643.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62695.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA09475.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE4A Gene

    Alternative splice isoforms for UBE4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE4A Gene

Proteomics data for UBE4A Gene at MOPED

Post-translational modifications for UBE4A Gene

  • Ubiquitination at Lys104, Lys468, Lys531, Lys679, Lys741, Lys766, and Lys774
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE4A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UBE4A Gene

Domains for UBE4A Gene

Gene Families for UBE4A Gene

HGNC:
  • UBOX :U-box domain containing

Protein Domains for UBE4A Gene

Graphical View of Domain Structure for InterPro Entry

Q14139

UniProtKB/Swiss-Prot:

UBE4A_HUMAN :
  • Q14139
Domain:
  • The U-box domain is required for the ubiquitin protein ligase activity.
  • Contains 1 U-box domain.
Family:
  • Belongs to the ubiquitin conjugation factor E4 family.
genes like me logo Genes that share domains with UBE4A: view

Function for UBE4A Gene

Molecular function for UBE4A Gene

GENATLAS Biochemistry: ubiquitination factor E4A,homologous to yeast UFD2,expressed in brain,required for multiubiquitin chain assembly,in association with E1,E2,E3,related to Drosophila NOSA
UniProtKB/Swiss-Prot Function: Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates Lys-48-linked polyubiquitination of substrates.

Enzyme Numbers (IUBMB) for UBE4A Gene

Gene Ontology (GO) - Molecular Function for UBE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 21903422
GO:0016874 ligase activity IEA --
GO:0034450 ubiquitin-ubiquitin ligase activity IEA --
genes like me logo Genes that share ontologies with UBE4A: view
genes like me logo Genes that share phenotypes with UBE4A: view

Animal Model Products

CRISPR Products

miRNA for UBE4A Gene

miRTarBase miRNAs that target UBE4A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE4A

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE4A Gene

Localization for UBE4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE4A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE4A Gene COMPARTMENTS Subcellular localization image for UBE4A gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for UBE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBE4A: view

Pathways for UBE4A Gene

genes like me logo Genes that share pathways with UBE4A: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat

UniProtKB/Swiss-Prot Q14139-UBE4A_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0006511 ubiquitin-dependent protein catabolic process IEA --
GO:0016567 protein ubiquitination --
genes like me logo Genes that share ontologies with UBE4A: view

Compounds for UBE4A Gene

(4) HMDB Compounds for UBE4A Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE4A: view

Transcripts for UBE4A Gene

mRNA/cDNA for UBE4A Gene

Unigene Clusters for UBE4A Gene

Ubiquitination factor E4A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE4A

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UBE4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE4A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b · 10c ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^
SP1: - - -
SP2: - - -
SP3:
SP4:
SP5:
SP6:

ExUns: 18 ^ 19 ^ 20a · 20b ^ 21
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:

Relevant External Links for UBE4A Gene

GeneLoc Exon Structure for
UBE4A
ECgene alternative splicing isoforms for
UBE4A

Expression for UBE4A Gene

mRNA expression in normal human tissues for UBE4A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE4A Gene

SOURCE GeneReport for Unigene cluster for UBE4A Gene Hs.75275

genes like me logo Genes that share expressions with UBE4A: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE4A Gene

Orthologs for UBE4A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE4A 35
  • 99.75 (n)
  • 99.72 (a)
UBE4A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE4A 35
  • 93.43 (n)
  • 96.9 (a)
UBE4A 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE4A 35
  • 95.06 (n)
  • 98.59 (a)
UBE4A 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube4a 35
  • 92.09 (n)
  • 97.18 (a)
Ube4a 16
Ube4a 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE4A 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE4A 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube4a 35
  • 91.59 (n)
  • 96.9 (a)
chicken
(Gallus gallus)
Aves UBE4A 35
  • 79.61 (n)
  • 88.27 (a)
UBE4A 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE4A 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube4a 35
  • 71.18 (n)
  • 78.44 (a)
zebrafish
(Danio rerio)
Actinopterygii ube4a 35
  • 70.64 (n)
  • 77.75 (a)
ube4a 36
  • 77 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001681 35
  • 48.62 (n)
  • 39.79 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11070 35
  • 49.98 (n)
  • 39 (a)
CG11070 36
  • 35 (a)
OneToOne
BcDNA:LD34475 37
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UFD2 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for UBE4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE4A Gene

ENSEMBL:
Gene Tree for UBE4A (if available)
TreeFam:
Gene Tree for UBE4A (if available)

Paralogs for UBE4A Gene

Paralogs for UBE4A Gene

genes like me logo Genes that share paralogs with UBE4A: view

Variants for UBE4A Gene

Sequence variations from dbSNP and Humsavar for UBE4A Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs502514 -- 118,371,280(+) cctac(C/T)ctatg intron-variant
rs513657 -- 118,378,297(-) TCTAT(C/T)TGTAG intron-variant
rs518939 -- 118,375,750(-) CTGCC(A/C)AATCC intron-variant
rs525619 -- 118,376,429(+) AAACC(A/C)AAAGA intron-variant
rs526337 -- 118,376,446(+) CAGAC(A/C)AAGAA intron-variant

Relevant External Links for UBE4A Gene

HapMap Linkage Disequilibrium report
UBE4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UBE4A Gene

Disorders for UBE4A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for UBE4A Gene including...

Search for UBE4A Gene in MalaCards »

(1) University of Copenhagen DISEASES for UBE4A Gene

genes like me logo Genes that share disorders with UBE4A: view

No data available for UniProtKB/Swiss-Prot for UBE4A Gene

Publications for UBE4A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. [Differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues]. (PMID: 17553343) Yang Y. … Yang H.J. (Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007) 3 23
  3. Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. (PMID: 18069675) Sakiyama T. … Tsubouchi H. (Inflamm. Bowel Dis. 2008) 3 23
  4. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  5. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. (PMID: 10089879) Koegl M. … Jentsch S. (Cell 1999) 2 3

Products for UBE4A Gene

Sources for UBE4A Gene

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