Aliases for UBE3C Gene
External Ids for UBE3C Gene
Previous GeneCards Identifiers for UBE3C Gene
GeneCards Summary for UBE3C Gene
UBE3C (Ubiquitin Protein Ligase E3C) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and SMAD Signaling Network. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is UBE3B.
UniProtKB/Swiss-Prot for UBE3C Gene
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either Lys-29- or Lys-48-linked polyubiquitin chains. Has preference for Lys-48 linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.