Aliases for UBE3C Gene
External Ids for UBE3C Gene
Previous GeneCards Identifiers for UBE3C Gene
GeneCards Summary for UBE3C Gene
UBE3C (Ubiquitin Protein Ligase E3C) is a Protein Coding gene. Diseases associated with UBE3C include kabuki syndrome 1. Among its related pathways are Immune System and SMAD Signaling Network. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is UBE3B.
UniProtKB/Swiss-Prot for UBE3C Gene
E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either Lys-29- or Lys-48-linked polyubiquitin chains. Has preference for Lys-48 linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo.