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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE3C Gene

protein-coding   GIFtS: 59
GCID: GC07P156931

ubiquitin protein ligase E3C
 Explore 5 diseases affiliated with
UBE3C via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UBE3C    

Aliases
for UBE3C gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin Protein Ligase E3C1 2     Ubiquitin-Protein Isopeptide Ligase (E3)2
KIAA00101 3     Ubiquitin-Protein Ligase E3C2
KIAA101 3     EC 6.3.2.-3
HECTH22     HectH23

External Ids:    HGNC: 168031   Entrez Gene: 96902   Ensembl: ENSG000000093357   OMIM: 6144545   UniProtKB: Q153863   

Export aliases for UBE3C gene to outside databases

Previous GC identifers: GC07P156349 GC07P156432 GC07P156624 GC07P150661


Summaries
for UBE3C gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386
Function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the
form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored
poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48'
linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo

Gene Wiki entry for UBE3C


Genomic Views
for UBE3C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007741.14  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE3C gene promoter:
         Egr-3   Pbx1a   Nkx2-5   GATA-1   Evi-1   S8   NF-AT4   NF-AT2   Nkx6-1   NF-AT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): UBE3C promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE3C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE3C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.3   Ensembl cytogenetic band:  7q36.3   HGNC cytogenetic band: 7q36.3

UBE3C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE3C gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P156931:  view genomic region     (about GC identifiers)

Start:
 156,931,607 bp from pter      End:
 157,062,066 bp from pter
Size:
 130,460 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 156,160,941-156,291,386     

Proteins
for UBE3C gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386 (See protein sequence)
Recommended Name: Ubiquitin-protein ligase E3C  
Size: 1083 amino acids; 123923 Da
Subunit: Interacts with 26S proteasomes. Interacts (via the N-terminal) with CAND2; the interaction stimulates
ubiquitination of CAND2 in vitro. May interact (via the HECT domain) with UBE2D1 and, less efficiently, with UBE2L3
Subcellular location: Nucleus (Potential)
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Sequence caution: Sequence=BAA02799.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A4D235 A6NCP3 Q8TC15 Q96CR4 Q9UDU3
Alternative splicing: 3 isoforms:  Q15386-1   Q15386-2   Q15386-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE3C: NX_Q15386

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15386

    • UBE3C Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055486.2  
    ENSEMBL proteins: 
     ENSP00000309198   ENSP00000373755   ENSP00000397432  
    Reactome Protein details: Q15386
    Human Recombinant Protein Products: 
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    Novus Biologicals UBE3C Proteins
    Novus Biologicals UBE3C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UBE3C

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000502proteasome complex IEA--
    GO:0005622intracellular IC11278995
    GO:0005634nucleus IBA--
    GO:0005737cytoplasm IBA--


    UBE3C for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for UBE3C gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UBE3C for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR000048 IQ_motif_EF-hand-BS
     IPR000569 HECT

    Graphical View of Domain Structure for InterPro Entry Q15386

    ProtoNet protein and cluster: Q15386

    1 Blocks protein family: IPB000569 HECT domain (Ubiquitin-protein ligase)

    UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386
    Domain: The C-terminal is necessary and sufficient for the poly-ubiquitin chain assembly
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 1 IQ domain


    Function
    for UBE3C gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386
    Function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the
    form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored
    poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48'
    linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    hsa-miR-2052 hsa-miR-142-5p hsa-miR-607 hsa-miR-4272 hsa-miR-106a hsa-miR-218-1* hsa-miR-3074-3p hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: UBE3C 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA11278995
    GO:0005515protein binding IPI12692129


    UBE3C for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UBE3C:
     Increased Salmonella enterica  


    Pathways & Interactions
    for UBE3C gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    3Ubiquitin-Proteasome Dependent Proteolysis
    		Ubiquitin-Proteasome Dependent Proteolysis1.00
    4SMAD Signaling Network
    		SMAD Signaling Network1.00
    5PEDF Induced Signaling
    		RAR-Gamma-RXR-Alpha Degradation0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE3C
        SMAD Signaling Network
    Ubiquitin-Proteasome Dependent Proteolysis
    RAR-Gamma-RXR-Alpha Degradation

    5        Reactome Pathways for UBE3C
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE3C):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386
    Pathway: Protein modification; protein ubiquitination


    UBE3C for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE3C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/13 Interacting proteins for UBE3C (Q153863 ENSP000003091984) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    CAND2O751553, ENSP000002959894I2D: score=2 STRING: ENSP00000295989
    PSMC5P621953, ENSP000003105724I2D: score=1 STRING: ENSP00000310572
    PSMD6Q150083, ENSP000002959014I2D: score=1 STRING: ENSP00000295901
    PTP4A3O753653, ENSP000003322744I2D: score=1 STRING: ENSP00000332274
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA11278995
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA--


    UBE3C for ontologies           About GeneDecksing



    Drugs & Compounds
    for UBE3C gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBE3C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UBE3C

    4 HMDB Compounds for UBE3C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    2 Novoseek chemical compound relationships for UBE3C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 25.4 1 15123615 (1)
    tyrosine 16.7 1 10940298 (1)

    Search CenterWatch for drugs/clinical trials and news about UBE3C 

    Transcripts
    for UBE3C gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UBE3C gene: 
    NM_014671.2  

    Unigene Cluster for UBE3C:

    Ubiquitin protein ligase E3C
    Hs.118351  [show with all ESTs]
    Unigene Representative Sequence: AK127280
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000348165(uc003wng.2 uc010lqs.3) ENST00000389103(uc003wnf.2)
    ENST00000430750 ENST00000469336 ENST00000470408(uc003wni.4) ENST00000497368
    ENST00000494532 ENST00000474153

    miRNA
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    8/49 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE3C (see all 49):
    hsa-miR-2052 hsa-miR-142-5p hsa-miR-607 hsa-miR-4272 hsa-miR-106a hsa-miR-218-1* hsa-miR-3074-3p hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmid: UBE3C 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE3C (see all 4)
    OriGene shRNA RFP: UBE3C
    OriGene siRNA: UBE3C
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    Clone
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    Additional cDNA sequence: 

    AK098447.1 AK127280.1 AK295138.1 BC014029.2 BC026241.1 D13635.1 

    18 DOTS entries:

    DT.101982691  DT.100790372  DT.216683  DT.40117231  DT.216684  DT.444687  DT.92447246  DT.100008290 
    DT.75109625  DT.97773562  DT.99933122  DT.99951754  DT.100027208  DT.100790375  DT.121079353  DT.121079397 
    DT.95276253  DT.98083610 

    24/255 AceView cDNA sequences (see all 255):

    BU626309 BC014029 AI359509 BF727191 BQ213214 BM765085 AL043761 AA596042 
    BQ962048 CA416751 BM760475 BQ048998 CB124141 BF516095 BC026241 AU121013 
    BU685227 CD557467 CB126638 AI332936 AU119548 BI868292 AW086203 AU131055 

    GeneLoc Exon Structure


    Expression
    for UBE3C gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE3C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UBE3C expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeGanglion Cell LayerMature Ganglion CellsGanglion, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UBE3C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE3C

    SOURCE GeneReport for Unigene cluster: Hs.118351

    UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386
    Tissue specificity: Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including UBE3C: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Orthologs
    for UBE3C gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UBE3C gene from 6/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UBE3C1 ubiquitin protein ligase E3C 81.29(n)
    90.77(a)    		   420447  NM_001030967.1  NP_001026138.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UBE3C6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 6(6464685-6514885)
    African clawed frog
    (Xenopus laevis)    		 Amphibia kiaa0010-prov2 ubiquitin-protein isopeptide ligase (E3) 76.55(n)    BC041723.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc636492 hypothetical protein MGC63649 75.38(n)   393445  BC055184.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG33561 CG3356 50.03(n)
    41.84(a)    		   37876  NM_138052.2  NP_611896.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea D2085.46
    		 Protein D2085.4
    		 24(a)
    		 1 ↔ 1
    		 II(8664781-8669108)


    ENSEMBL Gene Tree for UBE3C (if available)
    TreeFam Gene Tree for UBE3C (if available) 

    Paralogs
    for UBE3C gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE3C gene
    UBE3B2  
    5 SIMAP similar genes for UBE3C using alignment to 2 protein entries:     UBE3C_HUMAN (see all proteins):
    WWP2    HECTD1    DKFZp564H223    HUWE1    SMURF2

    UBE3C for paralogs           About GeneDecksing



    Genomic Variants
    for UBE3C gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2697 NCBI SNPs in UBE3C are shown (see all 2697)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs69502151,2
    		C,--156285000(+) TCAAGA/CTTGTA 1 -- us2k10--------
    rs737434021,2
    		C,--156285188(+) TTCCCG/AGAAAA 1 -- us2k12Minor allele frequency- A:0.05WA 120
    rs284053161,2
    		C,--156285239(+) CTAACA/GCCACC 1 -- us2k13Minor allele frequency- G:0.16CSA WA NA 240
    rs286456541,2
    		F,--156285255(+) CGGGCA/GCCTGT 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs64597491,2
    		C,F,A,--156285405(+) TCGAAC/TGGGgg 1 -- us2k17Minor allele frequency- T:0.14NA WA CSA EA 363
    rs790177471,2
    		C,--156285933(+) TGTGTG/ATTAAT 1 -- us2k12Minor allele frequency- A:0.03CSA WA 120
    rs1123380621,2
    		C,F--156286445(+) TGGTAC/TTACAG 1 -- nc-transcript-variant2Minor allele frequency- T:0.50NA 4
    rs1112657601,2
    		C,F--156286510(+) GTGTGC/AGCCAA 1 -- nc-transcript-variant2Minor allele frequency- A:0.50NA 4
    rs568369701,2
    		C,--156286734(+) GCATGC/TACCAC 1 -- nc-transcript-variant2Minor allele frequency- T:0.06WA 120
    rs758592931,2
    		--156287077(+) CCTTCG/ATTGTG 1 -- nc-transcript-variant1Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for UBE3C (156931607 - 157062066 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UBE3C: --
    Human Gene Mutation Database (HGMD): UBE3C

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for UBE3C gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UBE3C for disorders           About GeneDecksing

    OMIM gene information: 614454    OMIM disorders: --

    5 diseases for UBE3C:    About MalaCards
    major depressive disorder    parkinson's disease    angelman syndrome    cblc
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for UBE3C:
    Cocaine dependence

    2 Novoseek disease relationships for UBE3C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 29.8 1 15737990 (1)
    tumors 6.06 1 11517223 (1)

    Human Genome Epidemiology (HuGE) Navigator: UBE3C (5 documents)

    Export disorders for UBE3C gene to outside databases

    Publications
    for UBE3C gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE3C gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with UBE3C)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A HECT domain E3 enzyme assembles novel polyubiquitin chains. (PubMed id 11278995)1, 2, 3, 9 You J. and Pickart C.M. (2001)
    2. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2, 3 Nomura N.... Tabata S. (1994)
    3. Molecular determinants of polyubiquitin linkage selection by an HECT ubiquitin ligase. (PubMed id 16601690)1, 2 Wang M.... Pickart C.M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    6. Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. (PubMed id 12692129)1, 2 You J.... Pickart C.M. (2003)
    7. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    8. Characterization of human hect domain family members and their interaction with UbcH5 and UbcH7. (PubMed id 9575161)1, 2 Schwarz S.E....Scheffner M. (1998)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)

    External Searches for UBE3C gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UBE3C gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9690 HGNC: 16803 AceView: UBE3C Ensembl:ENSG00000009335 euGenes: HUgn9690
    ECgene: UBE3C Kegg: 9690 H-InvDB: UBE3C

    Other Databases showing UBE3C gene

    (According to HUGE)
    About This Section
    HUGE: KIAA10 KIAA0010

    Specialized Databases showing UBE3C gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE3C Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UBE3C gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UBE3C gene:
    Search GeneIP for patents involving UBE3C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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