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Aliases & Descriptions for UBE3C
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.3.2.- 3 | | KIAA0010 1, 2, 3 | | KIAA10 1, 2 |
| | | Descriptions |
|---|
| ubiquitin protein ligase E3C 2 | | ubiquitin-protein isopeptide ligase (E3) 2 |
|
| | Search outside databases for aliases for UBE3C genePrevious GC identifers: GC07P156349 GC07P156432 |
Summaries for UBE3C(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386Function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivoGene Wiki entry for UBE3C |
Genomic Location for UBE3C
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBE3C gene 
Entrez Gene cytogenetic band: 7q36.3 Ensembl cytogenetic band: 7q36.3 HGNC cytogenetic band: 7q36.3UBE3C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P156624:
(about GC identifiers)
Start:
|
156,624,425 bp from pter |
End:
|
156,754,823 bp from pter |
Size:
|
130,399 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 156,160,950-156,291,382 |
RefSeq DNA sequence:- NC_000007.12 NT_007741.13 NT_079596.2
| Proteins for UBE3C
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386 (See
protein sequence)Recommended Name: Ubiquitin-protein ligase E3C Size: 1083 amino acids; 123923 Da
Subunit: Interacts with 26S proteasomes. Binds CAND2
Subcellular location: Nucleus (Potential)
Miscellaneous: A cysteine residue is required for ubiquitin-thioester formation
Secondary accessions: A4D235 A6NCP3 Q8TC15 Q96CR4 Q9UDU3Alternative splicing: 3 isoforms: Q15386-1 Q15386-2 Q15386-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055486.2
ENSEMBL proteins: ENSP00000309198 ENSP00000373755
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for UBE3C: Assays for UBE3C: | Protein
Domains/ Families for UBE3C(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15386
ProtoNet protein and cluster: Q15386 1 Blocks protein family: IPB000569 HECT domain (Ubiquitin-protein ligase)
UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domainSimilarity: Contains 1 IQ domain | Gene Function for UBE3C
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014671
Applied Biosystems Silencer® siRNAs for UBE3C
Sigma-Aldrich siRNA and siRNA Panels for UBE3C  Sigma-Aldrich shRNA Panels and shRNA for UBE3C  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014671                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014671                                  untagged cDNA clone in CMV expression vector: NM_014671 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014671
UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386Function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivoEnzyme Number (IUBMB): EC 6.3.2.- 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for UBE3C
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386Pathway: Protein modification; protein ubiquitination 5/31 Interacting proteins for UBE3C (ENSP000003091983) via UniProtKB, MINT, and/or STRING (see all 31
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000209 | protein polyubiquitination |
IDA | 11278995 | | GO:0006464 | protein modification process |
IEA | -- | | GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | About this table
|
Drugs & Compounds for UBE3C(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBE3C 2 Novoseek chemical compound relationships for UBE3C gene
About this table
|
Transcripts for UBE3C(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014671
Sigma-Aldrich siRNA and siRNA Panels for UBE3C  Sigma-Aldrich shRNA Panels and shRNA for UBE3C  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014671 REFSEQ mRNAs for UBE3C gene: NM_014671.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014671               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014671                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014671                                  untagged cDNA clone in CMV expression vector: NM_014671  Additional cDNA sequence: AK098447.1 AK127280.1 AK295138.1 BC014029.2 BC026241.1 D13635.1 18 DOTS entries: DT.101982691 DT.100790372 DT.216683 DT.40117231 DT.216684 DT.444687 DT.92447246 DT.100008290 DT.75109625 DT.97773562 DT.99933122 DT.99951754 DT.100027208 DT.100790375 DT.121079353 DT.95276253 DT.98083610 DT.121079397 24/255 AceView cDNA sequences (see all 255
):BF727191 BM760475 AU121013 CB135281 CB126638 AI332936 BF516095 BM765085 BU521082 AJ707793 CK904337 BG166159 CA417485 AL043761 CD557467 BM787565 CA416751 BU626309 N57000 AU133428 BQ213214 BQ962048 CB124141 BU857363
highest scoring ESTs for UBE3C:D13635 AA256261 AA281377 AA284827 AA483805 AA502707 AA581864 AA596042 AA621492 AA626136 Unigene Cluster for UBE3C: Ubiquitin protein ligase E3C Hs.118351 [show with all ESTs]Unigene Representative Sequence: AK127280
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000348165
ENST00000389103
|
Expression for UBE3C
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBE3C expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBE3C
1 / 2 / 3 7 probe-sets matching UBE3C gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.118351
Expression variation in blood from EXPOLDB for UBE3C UniProtKB/Swiss-Prot: UBE3C_HUMAN, Q15386Tissue specificity: Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas |
Orthologs for UBE3C
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE3C gene from 5/14 species (see all 14
)
About this table Species with no ortholog for UBE3C
ENSEMBL Gene Tree for UBE3C | Paralogs for UBE3C(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBE3C gene
- KIAA03172 UBE3B2
|
SNPs/Variants for UBE3C(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBE3C (up to first 250kb)
|
Disorders & Mutations for UBE3C
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| 2 Novoseek disease relationships for UBE3C gene
About this table
|
Medical News for UBE3C(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBE3C (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/46 PubMed articles for UBE3C gene (see all 46
):- A HECT domain E3 enzyme assembles novel polyubiquitin chains. (PubMed id 11278995)1, 2, 3, 4 You J. and Pickart C.M. (2001)
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)2, 3, 4 Nomura N....Tabata S. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)3, 4 Scherer S.W....Tsui L.C. (2003)
- Proteolytic targeting of transcriptional regulator TIP120B by a HECT domain E3 ligase. (PubMed id 12692129)3, 4 You J.... Pickart C.M. (2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)3, 4 Hillier L.W.... Wilson R.K. (2003)
- Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PubMed id 17323924)4 Wang X.... Huang L. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). (PubMed id 7584028)3 Nomura N....Tabata S. (1994)
|
Search for UBE3C
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBE3C
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBE3C
(According to HUGE)
About This Section
| |
Specialized Databases showing UBE3C(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBE3C(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBE3C:

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Incremental update: 13 Oct 2009
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