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UBE3B Gene

protein-coding GIFtS: 54

GC12P108378

ubiquitin protein ligase E3B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp586K2123 ^²
DKFZp686A1051 ^²
EC 6.3.2.- ^³
FLJ45294 ^²
MGC131858 ^²
MGC78388 ^²

Descriptions
ubiquitin protein ligase E3B ^²

External Ids
HGNC: 13478¹
Entrez Gene: 89910²
UniProtKB: Q7Z3V4³
Ensembl: ENSG00000151148⁷

Search outside databases for aliases for UBE3B gene

Previous GC identifers: GC12P108973 GC12P109754

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for UBE3B:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E3 ubiquitin-conjugating

enzyme family. The encoded protein may interact with other proteins and play a role in stress

response. Alternatively spliced transcript variants encoding the same protein isoform have been

identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4

Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating

enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates

(By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE3B gene

Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.12

UBE3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P108378: (about GC identifiers)

Start:	108,399,822 bp from pter
End:	108,458,890 bp from pter
Size:	59,069 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4 (See protein sequence)

Recommended Name: Ubiquitin-protein ligase E3B

Size: 1068 amino acids; 123070 Da

Secondary accessions: A5D8Z3 Q05BX9 Q659F7 Q7Z7Q1 Q9BXZ4

Alternative splicing: 3 isoforms: Q7Z3V4-1 Q7Z3V4-2 Q7Z3V4-3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_569733.2 NP_904324.1

ENSEMBL proteins:

ENSP00000340596 ENSP00000280774 ENSP00000342614

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (UBE3B)
	Human Recombinant Proteins from Abnova (UBE3B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

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Antibodies for UBE3B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE3B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE3B)
	Novus Biologicals Antibody for UBE3B

Assays for UBE3B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q7Z3V4

ProtoNet protein and cluster: Q7Z3V4

1 Blocks protein family: IPB000569 HECT domain (Ubiquitin-protein ligase)

UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4

Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain

Similarity: Contains 1 IQ domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE3B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE3B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_130466

Applied Biosystems Silencer® siRNAs for UBE3B

Sigma-Aldrich siRNA and siRNA Panels for UBE3B

Sigma-Aldrich shRNA Panels and shRNA for UBE3B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_130466
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_130466
untagged cDNA clones in CMV expression vector (see all 2): NM_130466

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_130466

UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4

Function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating

enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates

(By similarity)

Enzyme Number (IUBMB): EC 6.3.2.-

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016874	ligase activity	IEA	--
GO:0016881	acid-amino acid ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for UBE3B (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway

GeneDecks UBE3B for the pathways selected above

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UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4

Pathway: Protein modification; protein ubiquitination

3 Interacting proteins for UBE3B (ENSP00000340596³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TRPV4	ENSP00000261740³	STRING (score=.874)
ATP2B1	ENSP00000352054³	STRING (score=.825)
ATP2A2	ENSP00000366913³	STRING (score=.824)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	IEA	--
GO:0019941	modification-dependent protein catabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE3B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE3B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE3B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_130466

Sigma-Aldrich siRNA and siRNA Panels for UBE3B

Sigma-Aldrich shRNA Panels and shRNA for UBE3B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_130466 NM_183415

REFSEQ mRNAs for UBE3B gene (2 alternative transcripts):

NM_130466.2 NM_183415.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_130466 NM_183415

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_130466
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_130466
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_130466

Additional cDNA sequence:

AF130072.1 AF251046.2 AK056015.1 AK301036.1 AK304678.1 AK307385.1 BC013182.1 BC020348.1

BC032301.1 BC040155.1 BC051266.1 BC068221.1 BC108705.1 BC141880.1 BC144684.1 BC150637.1

BX537403.1 CR600136.1 CR601612.1 CR613548.1 CR614569.1 CR616108.1

24 DOTS entries:

DT.454561 DT.92441920 DT.99989375 DT.95313053 DT.95313051 DT.101983921 DT.99981676 DT.75127322

DT.95179168 DT.100784663 DT.100703058 DT.65286904 DT.207681 DT.40125574 DT.75103797 DT.92441918

DT.97812263 DT.100705342 DT.121205054 DT.91863694 DT.92059583 DT.100695974 DT.75119309 DT.91741005

24/400 AceView cDNA sequences (see all 400 ):

BE243716 AW118987 AA781622 AI371974 CA488803 AA323742 BE242220 BI821961

AI091053 BU615241 AW136700 BC032301 BQ436381 AI034041 AA978104 BM792096

AI264287 BE792612 NM_183414 BM927617 AI142060 AI566129 AA398368 BM931238

highest scoring ESTs for UBE3B:

AI749193 AA013484 AA015723 AA016017 AA017421 AA017549 AA021187 AA021285 AA055649 AA056971

Unigene Cluster for UBE3B:

Ubiquitin protein ligase E3B

Hs.374067 [show with all ESTs]

Unigene Representative Sequence: NM_130466

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UBE3B (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^
SP1:					-		-										-												-		-		-
SP2:																	-												-		-		-
SP3:					-		-										-												-
SP4:																	-												-
SP5:							-										-												-

ExUns:	19	^	20	^	21	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for UBE3B

3 Ensembl transcripts including schematic representations:

ENST00000342494 ENST00000280774 ENST00000340074

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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UBE3B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE3B

¹ / ² / ³

15 probe-sets matching UBE3B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40622_r_at²^{, 3}	U95-A	1	1.00	1.00	0.27	1.22	AL096740	0.80	1.00	0.91	1
61889_at²^{, 3}	U95-C	1	1.00	1.00	0.64	0.92	AI738606	0.60	1.00	0.82	1
91730_at²^{, 3}	U95-E	1	1.00	1.00	0.56	0.78	AA705878	0.60	1.00	0.82	1
40623_at²^{, 3}	U95-A	1	1.00	1.00	0.03	1.17	AI749193	1.00	1.00	1.00	1
63981_at²^{, 3}	U95-C	1	0.69	1.00	0.58	0.93	AI202717	0.60	1.00	0.82	1
212404_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL096740	0.80	1.00	0.91	1
213822_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE856776	0.60	1.00	0.82	1
232301_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK022019	0.40	1.00	0.76	1
212403_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI749193	1.00	1.00	1.00	1
228860_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI738606	0.60	1.00	0.82	1
212404_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213822_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232301_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212403_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228860_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks UBE3B for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGGATTTTTG

SOURCE GeneReport for Unigene cluster: Hs.374067
Expression variation in blood from EXPOLDB for UBE3B
UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4
Tissue specificity: Widely expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE3B gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE3B¹	--	ubiquitin protein ligase E3B	91.23(n) 96.54(a)	486311 XM_543437.2 XP_543437.2
chimpanzee (Pan troglodytes)	UBE3B¹	--	ubiquitin protein ligase E3B	98.47(n) 98.22(a)	452223 XM_001136857.1 XP_001136857.1
cow (Bos taurus)	UBE3B¹	--	ubiquitin protein ligase E3B	89.7(n) 95.6(a)	512750 XM_867990.2 XP_873083.1
mouse (Mus musculus)	Ube3b^{1, 5}	5⁵	ubiquitin protein ligase E3B^{1, 5}	86.11(n)¹ 92.32(a)¹	117146¹ NM_054093.2¹ NP_473434.2¹ AA031195⁵ AF244362⁵ (see all 25)
zebrafish (Danio rerio)	DKEY-189P24.3¹	--	novel protein similar to ubiquitin protein ligase E3B more	73.86(n) 81.8(a)	556864 NM_001114682.1 NP_001108154.1

About this table Species with no ortholog for UBE3B

ENSEMBL Gene Tree for UBE3B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for UBE3B gene

KIAA0317² UBE3C²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/270 NCBI SNPs in UBE3B are shown (see all 270 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 149)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7298565^1,2	A,C,F,H	108421917(+)	`CTGTCG/AGAAGT`	2	Q/R	mis¹ ese³		12		EU EA WA	1254
	rs4766609^1,2	A,C,F,H	108457680(+)	`GTCCTA/GTGCAT`	2	--	ut3¹ ese³		7		NA EU EA WA	552
	rs1617^1,2	A,C,F,H	108458647(-)	`TGGTGC/TTTATA`	2	--	ut3¹ ese³		8		MN NA EU EA WA	744
	rs1045263^1,2	A,C,F,H	108458574(+)	`AGGGAA/GGATGG`	2	--	ut3¹		6		EA MN EU WA	2090
	rs2058807^1,2	A,C,F,H	108457656(-)	`GGAAGA/GCTCTC`	2	--	ut3¹		4		EU EA WA	412
--	rs1045255^1,2	A,C,F,H	108458362(+)	`GAAAAG/CAGTGT`	2	--	ut3¹		7		MN EA NA	1810
	rs14863^1,2	A,C,F,H	108458534(+)	`GGGTTC/TGTGCA`	2	--	ut3¹ ese³		13		MN NA EU EA WA	1201
	rs1045258^1,2	C,F,H	108458412(+)	`ACAGGA/GATGTA`	2	--	ut3¹ ese³		8		MN EU EA WA NA	686
	rs12367550^1,2	F,H	108457561(+)	`ACACCG/ATGAGT`	2	--	ut3¹ ese³		4		EU EA WA	420
--	rs1001382^1,2	A,C	108459314(+)	`attacC/Tggcat`	2	--	ng3¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for UBE3B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608047

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10 PubMed articles for UBE3B gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of the human UBE3B gene: structure, expression, evolution, and alternative splicing. (PubMed id 12837265)^{3, 4} Gong T.-W.L.... Lomax M.I. (2003)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. (PubMed id 17672918)³ Szafranski K....Platzer M. (2007)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PubMed id 11483580)³ Yu Y....He F. (2001)
Differential Gene Expression Following Noise Trauma in Birds and Mammals. (PubMed id 12689446)³ Lomax M.I....Altschuler R.A. (2001)
Differential display and gene arrays to examine auditory plasticity. (PubMed id 10962193)³ Lomax M.I....Altschuler R.A. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 89910	HGNC: 13478	AceView: UBE3B	Ensembl:ENSG00000151148	euGenes: HUgn89910
ECgene: UBE3B	H-InvDB: UBE3B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for UBE3B
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE3B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE3B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE3B		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE3B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBE3B)
	Antibodies (UBE3B)
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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for UBE3B

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Antibodies for UBE3B

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UBE3B Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for UBE3B

Summaries
for UBE3B

Genomic Location
for UBE3B

Proteins
for UBE3B

Protein Domains/
Families
for UBE3B

Gene Function
for UBE3B

Pathways & Interactions
for UBE3B

Drugs & Compounds
for UBE3B

Transcripts
for UBE3B

Expression
for UBE3B

Orthologs
for UBE3B

Paralogs
for UBE3B

SNPs/Variants
for UBE3B

Disorders & Mutations
for UBE3B

Medical News
for UBE3B

Publications
for UBE3B

Search for UBE3B

Genome Databases showing UBE3B

Other Databases showing UBE3B

Specialized Databases showing UBE3B

Licensable Technologies
for UBE3B

Services
for UBE3B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE3B Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor UBE3B

Summariesfor UBE3B

Genomic Locationfor UBE3B

Proteinsfor UBE3B

Protein Domains/Familiesfor UBE3B

Gene Functionfor UBE3B

Pathways & Interactionsfor UBE3B

Drugs & Compoundsfor UBE3B

Transcriptsfor UBE3B

Expression for UBE3B

Orthologsfor UBE3B

Paralogsfor UBE3B

SNPs/Variantsfor UBE3B

Disorders & Mutationsfor UBE3B

Medical Newsfor UBE3B

Publicationsfor UBE3B

Search for UBE3B

Genome Databases showing UBE3B

Other Databases showing UBE3B

Specialized Databases showing UBE3B

Licensable Technologiesfor UBE3B

Servicesfor UBE3B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE3B

Summaries
for UBE3B

Genomic Location
for UBE3B

Proteins
for UBE3B

Protein Domains/
Families
for UBE3B

Gene Function
for UBE3B

Pathways & Interactions
for UBE3B

Drugs & Compounds
for UBE3B

Transcripts
for UBE3B

Expression
for UBE3B

Orthologs
for UBE3B

Paralogs
for UBE3B

SNPs/Variants
for UBE3B

Disorders & Mutations
for UBE3B

Medical News
for UBE3B

Publications
for UBE3B

Licensable Technologies
for UBE3B

Services
for UBE3B