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Aliases & Descriptions for UBE3B
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp586K2123 2 DKFZp686A1051 2 EC 6.3.2.- 3 FLJ45294 2 MGC131858 2 MGC78388 2
Descriptions ubiquitin protein ligase E3B 2
Search outside databases for aliases for UBE3B genePrevious GC identifers: GC12P108973 GC12P109754
Summaries for UBE3B (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for UBE3B : The modification of proteins with ubiquitin is an important cellular mechanism for targetingabnormal or short-lived proteins for degradation. Ubiquitination involves at least three classesof enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, andubiquitin-protein ligases, or E3s. This gene encodes a member of the E3 ubiquitin-conjugatingenzyme family. The encoded protein may interact with other proteins and play a role in stressresponse. Alternatively spliced transcript variants encoding the same protein isoform have beenidentified for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4 Function : E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugatingenzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates(By similarity)
Genomic Location for UBE3B
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the UBE3B gene Entrez Gene cytogenetic band: 12q24.11 Ensembl cytogenetic band: 12q24.11 HGNC cytogenetic band: 12q24.12 UBE3B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P108378:
(about GC identifiers )
Start:
108,399,822 bp from pter
End:
108,458,890 bp from pter
Size:
59,069 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000012.10 NT_009775.16 Proteins for UBE3B
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4 (See
protein sequence )Recommended Name: Ubiquitin-protein ligase E3B Size : 1068 amino acids; 123070 Da
Secondary accessions : A5D8Z3 Q05BX9 Q659F7 Q7Z7Q1 Q9BXZ4Alternative splicing : 3 isoforms : Q7Z3V4-1 Q7Z3V4-2 Q7Z3V4-3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_569733.2 NP_904324.1 ENSEMBL proteins: ENSP00000340596 ENSP00000280774 ENSP00000342614 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005622 intracellular
IEA --
About this table Antibodies for UBE3B: Assays for UBE3B:
Protein
Domains/ Families for UBE3B(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q7Z3V4 ProtoNet protein and cluster: Q7Z3V4
1 Blocks protein family : IPB000569 HECT domain (Ubiquitin-protein ligase) UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4 Similarity : Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domainSimilarity : Contains 1 IQ domain
Gene Function for UBE3B
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_130466 Applied Biosystems Silencer ® siRNAs for UBE3B Sigma-Aldrich siRNA and siRNA Panels for UBE3B Sigma-Aldrich shRNA Panels and shRNA for UBE3B Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_130466                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_130466                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_130466  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_130466 UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4 Function : E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugatingenzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates(By similarity) Enzyme Number (IUBMB): EC 6.3.2.-
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016874 ligase activity
IEA -- GO:0016881 acid-amino acid ligase activity
IEA --
About this table
Pathways & Interactions for UBE3B
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for UBE3B (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4 Pathway : Protein modification; protein ubiquitination
3 Interacting proteins for UBE3B (ENSP00000340596 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006464 protein modification process
IEA -- GO:0019941 modification-dependent protein catabolic process
IEA --
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Drugs & Compounds for UBE3B (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for UBE3B
Transcripts for UBE3B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_130466 Sigma-Aldrich siRNA and siRNA Panels for UBE3B Sigma-Aldrich shRNA Panels and shRNA for UBE3B Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_130466 NM_183415
REFSEQ mRNAs for UBE3B gene (2 alternative transcripts): NM_130466.2 NM_183415.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_130466 NM_183415
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_130466                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_130466                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_130466  
Additional cDNA sequence: AF130072.1 AF251046.2 AK056015.1 AK301036.1 AK304678.1 AK307385.1 BC013182.1 BC020348.1 BC032301.1 BC040155.1 BC051266.1 BC068221.1 BC108705.1 BC141880.1 BC144684.1 BC150637.1 BX537403.1 CR600136.1 CR601612.1 CR613548.1 CR614569.1 CR616108.1
24 DOTS entries : DT.454561 DT.92441920 DT.99989375 DT.95313053 DT.95313051 DT.101983921 DT.99981676 DT.75127322 DT.95179168 DT.100784663 DT.100703058 DT.65286904 DT.207681 DT.40125574 DT.75103797 DT.92441918 DT.97812263 DT.100705342 DT.121205054 DT.91863694 DT.92059583 DT.100695974 DT.75119309 DT.91741005
24/400 AceView cDNA sequences (see all 400
):BE243716 AW118987 AA781622 AI371974 CA488803 AA323742 BE242220 BI821961 AI091053 BU615241 AW136700 BC032301 BQ436381 AI034041 AA978104 BM792096 AI264287 BE792612 NM_183414 BM927617 AI142060 AI566129 AA398368 BM931238
highest scoring ESTs for UBE3B :AI749193 AA013484 AA015723 AA016017 AA017421 AA017549 AA021187 AA021285 AA055649 AA056971
Unigene Cluster for UBE3B: Ubiquitin protein ligase E3B Hs.374067 [show with all ESTs ] Unigene Representative Sequence: NM_130466 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UBE3B (see all 8
) ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ SP1 :     -   -           -             -   -   -                     SP2 :                 -             -   -   -                     SP3 :     -   -           -             -                         SP4 :                 -             -                         SP5 :       -           -             -                        
ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 SP1 :                       SP2 :                       SP3 :                       SP4 :                       SP5 :                      
About this scheme ECgene alternative splicing isoforms for UBE3B 3 Ensembl transcripts including schematic representations : ENST00000342494
ENST00000280774
ENST00000340074
Expression for UBE3B
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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UBE3B expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for UBE3B 1 / 2 / 3
15 probe-sets matching UBE3B gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGGATTTTTGSOURCE GeneReport for Unigene cluster: Hs.374067 Expression variation in blood from EXPOLDB for UBE3B
UniProtKB/Swiss-Prot: UBE3B_HUMAN, Q7Z3V4 Tissue specificity : Widely expressed
Orthologs for UBE3B
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for UBE3B gene from 5/10 species (see all 10
)
About this table Species with no ortholog for UBE3B ENSEMBL Gene Tree for UBE3B Paralogs for UBE3B (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for UBE3B gene KIAA0317 2 UBE3C 2
SNPs/Variants for UBE3B (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for UBE3B (up to first 250kb)
Disorders & Mutations for UBE3B
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 608047
Medical News for UBE3B (Possibly Related Articles in
Doctor's Guide )
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--
Publications for UBE3B (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10 PubMed articles for UBE3B gene :
Search for UBE3B
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing UBE3B
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing UBE3B
(According to HUGE )
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--
Specialized Databases showing UBE3B (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for UBE3B (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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