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Aliases for UBE2Z Gene

Aliases for UBE2Z Gene

  • Ubiquitin-Conjugating Enzyme E2Z 2 3
  • Uba6-Specific E2 Conjugating Enzyme 1 3 4
  • Ubiquitin Carrier Protein Z 3 4
  • Ubiquitin-Protein Ligase Z 3 4
  • UBA6-Specific Enzyme E2 2 3
  • EC 6.3.2.19 4 63
  • USE1 3 4
  • Ubiquitin-Conjugating Enzyme E2 Z 3
  • HOYS7 3

External Ids for UBE2Z Gene

Previous GeneCards Identifiers for UBE2Z Gene

  • GC17P044341
  • GC17P046985
  • GC17P042357

Summaries for UBE2Z Gene

Entrez Gene Summary for UBE2Z Gene

  • This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]

GeneCards Summary for UBE2Z Gene

UBE2Z (Ubiquitin-Conjugating Enzyme E2Z) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2O.

UniProtKB/Swiss-Prot for UBE2Z Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2Z Gene

Genomics for UBE2Z Gene

Regulatory Elements for UBE2Z Gene

Genomic Location for UBE2Z Gene

Start:
48,908,369 bp from pter
End:
48,929,060 bp from pter
Size:
20,692 bases
Orientation:
Plus strand

Genomic View for UBE2Z Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2Z Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Z Gene

Proteins for UBE2Z Gene

  • Protein details for UBE2Z Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H832-UBE2Z_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Z
    Protein Accession:
    Q9H832
    Secondary Accessions:
    • A6N8M6
    • A6NC60
    • Q7L354
    • Q8TCM4
    • Q9H893

    Protein attributes for UBE2Z Gene

    Size:
    354 amino acids
    Molecular mass:
    38210 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15890.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14724.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UBE2Z Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2Z Gene

Proteomics data for UBE2Z Gene at MOPED

Post-translational modifications for UBE2Z Gene

  • Ubiquitination at Lys166
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2Z Gene

Domains for UBE2Z Gene

Gene Families for UBE2Z Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2Z Gene

Suggested Antigen Peptide Sequences for UBE2Z Gene

Graphical View of Domain Structure for InterPro Entry

Q9H832

UniProtKB/Swiss-Prot:

UBE2Z_HUMAN :
  • Q9H832
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Z: view

Function for UBE2Z Gene

Molecular function for UBE2Z Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation.

Enzyme Numbers (IUBMB) for UBE2Z Gene

Gene Ontology (GO) - Molecular Function for UBE2Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24528925
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity IBA --
genes like me logo Genes that share ontologies with UBE2Z: view

Phenotypes for UBE2Z Gene

genes like me logo Genes that share phenotypes with UBE2Z: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2Z Gene

Localization for UBE2Z Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Z Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2Z Gene COMPARTMENTS Subcellular localization image for UBE2Z gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBE2Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with UBE2Z: view

Pathways for UBE2Z Gene

genes like me logo Genes that share pathways with UBE2Z: view

UniProtKB/Swiss-Prot Q9H832-UBE2Z_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Z Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006915 apoptotic process IEA --
GO:0008152 metabolic process --
GO:0016567 protein ubiquitination --
genes like me logo Genes that share ontologies with UBE2Z: view

Compounds for UBE2Z Gene

(4) HMDB Compounds for UBE2Z Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2Z: view

Transcripts for UBE2Z Gene

Unigene Clusters for UBE2Z Gene

Ubiquitin-conjugating enzyme E2Z:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Z Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b
SP1: - - - -
SP2: - - -
SP3: -
SP4:
SP5: - -

Relevant External Links for UBE2Z Gene

GeneLoc Exon Structure for
UBE2Z
ECgene alternative splicing isoforms for
UBE2Z

Expression for UBE2Z Gene

mRNA expression in normal human tissues for UBE2Z Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2Z Gene

SOURCE GeneReport for Unigene cluster for UBE2Z Gene Hs.514297

mRNA Expression by UniProt/SwissProt for UBE2Z Gene

Q9H832-UBE2Z_HUMAN
Tissue specificity: Widely expressed. Highly in placenta, pancreas, spleen and testis.
genes like me logo Genes that share expressions with UBE2Z: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBE2Z Gene

Orthologs for UBE2Z Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBE2Z Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2Z 35
  • 99.19 (n)
  • 100 (a)
UBE2Z 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2Z 35
  • 95.57 (n)
  • 99.68 (a)
UBE2Z 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2Z 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2z 35
  • 93.22 (n)
  • 98.31 (a)
Ube2z 16
Ube2z 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2Z 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2Z 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2z 35
  • 93.31 (n)
  • 98.59 (a)
chicken
(Gallus gallus)
Aves UBE2Z 35
  • 82.28 (n)
  • 86.97 (a)
UBE2Z 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2Z 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC69155 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10246 35
ube2z 35
  • 76.75 (n)
  • 84.87 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8725 35
zebrafish
(Danio rerio)
Actinopterygii Dr.28857 35
ube2z 35
  • 72.94 (n)
  • 81.18 (a)
ube2z 36
  • 63 (a)
OneToOne
Species with no ortholog for UBE2Z:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2Z Gene

ENSEMBL:
Gene Tree for UBE2Z (if available)
TreeFam:
Gene Tree for UBE2Z (if available)

Paralogs for UBE2Z Gene

Paralogs for UBE2Z Gene

genes like me logo Genes that share paralogs with UBE2Z: view

Variants for UBE2Z Gene

Sequence variations from dbSNP and Humsavar for UBE2Z Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs14421 -- 48,916,093(+) ACCTG(C/T)CTGGA reference, missense
rs15563 -- 48,927,831(-) TTTAC(C/T)TTCTG utr-variant-3-prime
rs46521 -- 48,911,167(+) caaaa(A/G)tgctc intron-variant
rs46522 -- 48,911,235(+) CCATC(C/T)CGTTA intron-variant
rs170319 -- 48,914,169(-) CCCCC(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2Z Gene

Variant ID Type Subtype PubMed ID
nsv482969 CNV Loss 15286789
nsv833472 CNV Gain 17160897
nsv2073 CNV Insertion 18451855

Relevant External Links for UBE2Z Gene

HapMap Linkage Disequilibrium report
UBE2Z

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2Z Gene

Disorders for UBE2Z Gene

Relevant External Links for UBE2Z

Genetic Association Database (GAD)
UBE2Z
Human Genome Epidemiology (HuGE) Navigator
UBE2Z
genes like me logo Genes that share disorders with UBE2Z: view

No data available for UniProtKB/Swiss-Prot for UBE2Z Gene

Publications for UBE2Z Gene

  1. Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. (PMID: 17597759) Jin J. … Harper J.W. (Nature 2007) 2 3 4
  2. Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z). (PMID: 17160626) Gu X. … Mao Y. (Mol. Biol. Rep. 2007) 3 4 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. (PMID: 21378990) Schunkert H. … Samani N.J. (Nat. Genet. 2011) 3 48

Products for UBE2Z Gene

Sources for UBE2Z Gene

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