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Aliases & Descriptions for UBE2Z
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.3.2.19 3 | | FLJ13855 1, 2 | | HOYS7 2 | | USE1 1, 2 | | Use1 3 |
| | | Descriptions |
|---|
| UBA6-specific enzyme E2 2 | | Uba6-specific E2 conjugating enzyme 1 3 | | Ubiquitin carrier protein Z 3 | | Ubiquitin-protein ligase Z 3 | | ubiquitin-conjugating enzyme E2Z 2 |
|
| | Search outside databases for aliases for UBE2Z gene |
Summaries for UBE2Z(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for UBE2Z: Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE2Z is an E2 enzyme (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM] UniProtKB/Swiss-Prot: UBE2Z_HUMAN, Q9H832Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBE1L2, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation |
Genomic Location for UBE2Z
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBE2Z gene 
Entrez Gene cytogenetic band: 17q21.32 Ensembl cytogenetic band: 17q21.32 HGNC cytogenetic band: 17q21.32UBE2Z Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P044341:
(about GC identifiers)
Start:
|
44,340,730 bp from pter |
End:
|
44,361,421 bp from pter |
Size:
|
20,692 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010783.14
| Proteins for UBE2Z
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBE2Z_HUMAN, Q9H832 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 Z Size: 354 amino acids; 38210 Da
Subcellular location: Cytoplasm. Nucleus
Secondary accessions: A6N8M6 Q7L354 Q8TCM4 Q9H893Alternative splicing: 2 isoforms: Q9H832-1 Q9H832-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_075567.2
ENSEMBL proteins: ENSP00000354201 ENSP00000386109 ENSP00000374259
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for UBE2Z: Assays for UBE2Z: | Protein
Domains/ Families for UBE2Z(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H832
ProtoNet protein and cluster: Q9H832 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBE2Z_HUMAN, Q9H832Similarity: Belongs to the ubiquitin-conjugating enzyme family | Gene Function for UBE2Z
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_023079
Applied Biosystems Silencer® siRNAs for UBE2Z
Sigma-Aldrich siRNA and siRNA Panels for UBE2Z  Sigma-Aldrich shRNA Panels and shRNA for UBE2Z  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_023079                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_023079                                  untagged cDNA clones in CMV expression vector (see all 2): NM_023079 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_023079
UniProtKB/Swiss-Prot: UBE2Z_HUMAN, Q9H832Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBE1L2, not charged with ubiquitin by UBE1. May be involved in apoptosis regulationCatalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- | | GO:0016874 | ligase activity |
IEA | -- | About this table | Pathways & Interactions for UBE2Z
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: UBE2Z_HUMAN, Q9H832Pathway: Protein modification; protein ubiquitination 5 Interacting proteins for UBE2Z (ENSP000003742593 Q9H8322) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptosis |
IEA | -- | | GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for UBE2Z(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBE2Z
|
Transcripts for UBE2Z(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_023079
Sigma-Aldrich siRNA and siRNA Panels for UBE2Z  Sigma-Aldrich shRNA Panels and shRNA for UBE2Z  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_023079 REFSEQ mRNAs for UBE2Z gene: NM_023079.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_023079               OriGene GFP tagged cDNA clone in CMV expression vector: NM_023079                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_023079                                  untagged cDNA clones in CMV expression vector (see all 2): NM_023079  Additional cDNA sequence: AB025426.1 AK023917.1 AK024030.1 AK091644.1 AK122770.1 AK130303.1 AK296865.1 AL713782.1 BC015169.1 BC015890.1 CR457322.1 EF623992.1 23 DOTS entries: DT.456081 DT.101966986 DT.100826843 DT.97851377 DT.99957834 DT.100826844 DT.120911283 DT.120911314 DT.120911417 DT.91759275 DT.91759295 DT.101984794 DT.102844558 DT.120911414 DT.120911425 DT.75101708 DT.75149705 DT.91759293 DT.95223440 DT.100649701 DT.219192 DT.95225735 DT.99942923 24/436 AceView cDNA sequences (see all 436
):AK122770 CA952898 BQ130583 CD672198 CD518800 AA845421 T87836 AI669613 AW103048 AA445998 BM738472 BE501620 BM803464 BM272571 AA460943 AW006025 CA422112 BE857552 CA417956 AI095613 CB321809 CB529140 AW071453 BI757130
highest scoring ESTs for UBE2Z:AI027524 AA027972 AA027973 AA029054 AA029157 AA043352 AA043353 AA100618 AA100619 AA147920 Unigene Cluster for UBE2Z: Ubiquitin-conjugating enzyme E2Z Hs.514297 [show with all ESTs]Unigene Representative Sequence: AK091644
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Z
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | |
| SP1: | |   | - |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBE2Z
3 Ensembl transcripts including schematic representations: ENST00000360943
ENST00000405215
ENST00000389608
|
Expression for UBE2Z
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBE2Z expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBE2Z
1 / 2 / 3 8 probe-sets matching UBE2Z gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TCTGGCATAG
SOURCE GeneReport for Unigene cluster: Hs.514297 UniProtKB/Swiss-Prot: UBE2Z_HUMAN, Q9H832Tissue specificity: Widely expressed. Highly in placenta, pancreas, spleen and testis |
Orthologs for UBE2Z
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2Z gene from 5/7 species (see all 7
)
About this table Species with no ortholog for UBE2Z
ENSEMBL Gene Tree for UBE2Z | Paralogs for UBE2Z(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBE2Z gene
- UBE2O2 BIRC62
|
SNPs/Variants for UBE2Z(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBE2Z (up to first 250kb)
|
Disorders & Mutations for UBE2Z
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611362
|
Medical News for UBE2Z(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBE2Z (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for UBE2Z gene (see all 12
): |
Search for UBE2Z
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBE2Z
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBE2Z
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2Z(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBE2Z(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBE2Z:

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| | | | Search Tocris compounds for UBE2Z |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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