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Aliases for UBE2W Gene

Aliases for UBE2W Gene

  • Ubiquitin Conjugating Enzyme E2 W 2 3 5
  • N-Terminal E2 Ubiquitin-Conjugating Enzyme 2 3 4
  • E2 Ubiquitin-Conjugating Enzyme W 2 3 4
  • Ubiquitin-Conjugating Enzyme 16 2 3 4
  • Ubiquitin Carrier Protein W 2 3 4
  • Ubiquitin-Protein Ligase W 2 3 4
  • N-Terminus-Conjugating E2 2 3 4
  • Ubiquitin Conjugating Enzyme E2 W (Putative) 2 3
  • UBC-16 3 4
  • UBC16 3 4
  • Ubiquitin-Conjugating Enzyme E2W (Putative) 2
  • Ubiquitin Conjugating Enzyme E2W (Putative) 3
  • Ubiquitin-Conjugating Enzyme E2 W 3
  • Ubiquitin-Conjugating Enzyme 2W 3
  • EC 6.3.2.19 61
  • EC 2.3.2.23 4
  • EC 2.3.2.25 4

External Ids for UBE2W Gene

Previous GeneCards Identifiers for UBE2W Gene

  • GC08M074866
  • GC08M074702
  • GC08M070193
  • GC08M074692

Summaries for UBE2W Gene

Entrez Gene Summary for UBE2W Gene

  • This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for UBE2W Gene

UBE2W (Ubiquitin Conjugating Enzyme E2 W) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is ENSG00000258677.

UniProtKB/Swiss-Prot for UBE2W Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes Lys-11-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2W Gene

Genomics for UBE2W Gene

Regulatory Elements for UBE2W Gene

Enhancers for UBE2W Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G073834 1 Ensembl ENCODE 11.3 +43.6 43570 1.9 TBP BACH1 FOSL1 ARID3A CBX5 EED RELB IKZF2 MTA2 TRIM22 UBE2W STAU2 RN7SL760P ENSG00000258677
GH08G073975 1 ENCODE 10.3 -97.5 -97537 2.1 PKNOX1 ATF1 ARNT CREB3L1 ARID4B E2F7 SIN3A DMAP1 ZNF2 ZNF48 TMEM70 UBE2W GC08M073979
GH08G073876 1.1 ENCODE 7.2 +0.2 209 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A ZBTB7B YY1 ZNF143 SP3 SP5 TMEM70 ELOC UBE2W ENSG00000258677 RN7SL760P
GH08G073934 0.7 ENCODE 10.7 -56.3 -56257 1.4 JUN JUNB FOSL1 CTBP1 NFIC JUND GATA3 ATF3 GATA2 IKZF1 UBE2W GC08P073922 GC08P073966
GH08G073967 0.7 ENCODE 10.5 -87.6 -87571 0.2 HDAC1 HLF CEBPB CEBPG IRF9 CEBPA IKZF1 FOS NFE2 PRDM1 LY96 UBE2W TMEM70 GC08P073966 GC08M073941
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2W on UCSC Golden Path with GeneCards custom track

Promoters for UBE2W Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000225929 310 2801 HDGF PKNOX1 ARNT ARID4B SIN3A ZBTB7B YY1 ZNF143 SP3 SP5

Genomic Location for UBE2W Gene

Chromosome:
8
Start:
73,780,097 bp from pter
End:
73,878,910 bp from pter
Size:
98,814 bases
Orientation:
Minus strand

Genomic View for UBE2W Gene

Genes around UBE2W on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2W Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2W Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2W Gene

Proteins for UBE2W Gene

  • Protein details for UBE2W Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B02-UBE2W_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 W
    Protein Accession:
    Q96B02
    Secondary Accessions:
    • B4DIV1
    • Q1XBE0
    • Q9H823
    • Q9HAG6
    • Q9NV07

    Protein attributes for UBE2W Gene

    Size:
    151 amino acids
    Molecular mass:
    17331 Da
    Quaternary structure:
    • Homodimer. Interacts with FANCL (Ref.7). Interacts with STUB1/CHIP (By similarity).

    Three dimensional structures from OCA and Proteopedia for UBE2W Gene

    Alternative splice isoforms for UBE2W Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2W Gene

Selected DME Specific Peptides for UBE2W Gene

Q96B02:
  • LSIISMLS
  • YSNGHICL

Post-translational modifications for UBE2W Gene

  • Ubiquitinated in vitro in the presence of FANCL (By similarity). Autoubiquitinated at Met-1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UBE2W Gene

Gene Families for UBE2W Gene

Protein Domains for UBE2W Gene

Graphical View of Domain Structure for InterPro Entry

Q96B02

UniProtKB/Swiss-Prot:

UBE2W_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2W: view

Function for UBE2W Gene

Molecular function for UBE2W Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes Lys-11-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.

Enzyme Numbers (IUBMB) for UBE2W Gene

Gene Ontology (GO) - Molecular Function for UBE2W Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 21229326
GO:0005515 protein binding IPI 19549727
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 19111657
genes like me logo Genes that share ontologies with UBE2W: view
genes like me logo Genes that share phenotypes with UBE2W: view

Animal Models for UBE2W Gene

MGI Knock Outs for UBE2W:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2W

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2W Gene

Localization for UBE2W Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2W Gene

Nucleus. Note=In the nucleus, colocalizes with FANCL.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2W gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for UBE2W Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with UBE2W: view

Pathways & Interactions for UBE2W Gene

genes like me logo Genes that share pathways with UBE2W: view

Pathways by source for UBE2W Gene

UniProtKB/Swiss-Prot Q96B02-UBE2W_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2W Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006513 protein monoubiquitination IMP 21229326
GO:0006515 misfolded or incompletely synthesized protein catabolic process ISS --
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0016567 protein ubiquitination TAS --
genes like me logo Genes that share ontologies with UBE2W: view

No data available for SIGNOR curated interactions for UBE2W Gene

Drugs & Compounds for UBE2W Gene

(3) Drugs for UBE2W Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2W Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2W: view

Transcripts for UBE2W Gene

Unigene Clusters for UBE2W Gene

Ubiquitin-conjugating enzyme E2W (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2W

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2W Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: - -

Relevant External Links for UBE2W Gene

GeneLoc Exon Structure for
UBE2W
ECgene alternative splicing isoforms for
UBE2W

Expression for UBE2W Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2W Gene

Protein differential expression in normal tissues from HIPED for UBE2W Gene

This gene is overexpressed in Testis (37.6), Pancreas (17.3), and Prostate (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBE2W Gene



Protein tissue co-expression partners for UBE2W Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2W Gene:

UBE2W

SOURCE GeneReport for Unigene cluster for UBE2W Gene:

Hs.128841

mRNA Expression by UniProt/SwissProt for UBE2W Gene:

Q96B02-UBE2W_HUMAN
Tissue specificity: Widely expressed, with highest expression in brain, liver, pancreas and heart.

Evidence on tissue expression from TISSUES for UBE2W Gene

  • Nervous system(4.7)
genes like me logo Genes that share expression patterns with UBE2W: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2W Gene

Orthologs for UBE2W Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2W Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2W 34 35
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia UBE2W 34 35
  • 98.23 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia UBE2W 34
  • 96.67 (n)
-- 35
  • 83 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 96 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ube2wl 34
  • 94.75 (n)
mouse
(Mus musculus)
Mammalia Ube2w 34 16 35
  • 94.07 (n)
chicken
(Gallus gallus)
Aves UBE2W 34 35
  • 90.95 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2w 34
  • 86.09 (n)
Str.19999 34
zebrafish
(Danio rerio)
Actinopterygii ube2w 35
  • 90 (a)
ManyToMany
flj11011l 34 35
  • 84.11 (n)
Dr.17665 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005324 34
  • 66.89 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7220 34 35
  • 65.07 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-16 34 35
  • 58.85 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC11 35
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC16 34
  • 59.71 (n)
Species where no ortholog for UBE2W was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2W Gene

ENSEMBL:
Gene Tree for UBE2W (if available)
TreeFam:
Gene Tree for UBE2W (if available)

Paralogs for UBE2W Gene

Pseudogenes.org Pseudogenes for UBE2W Gene

genes like me logo Genes that share paralogs with UBE2W: view

Variants for UBE2W Gene

Sequence variations from dbSNP and Humsavar for UBE2W Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000009912 -- 73,855,509(+) CAATT(G/T)TCCTG intron-variant
rs1000020447 -- 73,815,660(+) TACCA(C/T)GAAGG intron-variant
rs1000052431 -- 73,808,689(+) TTTAT(C/T)GTATT intron-variant
rs1000069166 -- 73,861,971(+) AATCT(C/T)GAATT intron-variant
rs1000070097 -- 73,782,028(+) TTCCA(C/T)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2W Gene

Variant ID Type Subtype PubMed ID
esv1048357 CNV deletion 17803354
esv2678738 CNV deletion 23128226
esv2737169 CNV deletion 23290073
esv2737170 CNV deletion 23290073
esv3115943 CNV deletion 24192839
nsv471760 CNV loss 16327809

Variation tolerance for UBE2W Gene

Gene Damage Index Score: 2.33; 41.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2W Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2W

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2W Gene

Disorders for UBE2W Gene

Relevant External Links for UBE2W

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2W

No disorders were found for UBE2W Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2W Gene

Publications for UBE2W Gene

  1. The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates. (PMID: 23696636) Scaglione K.M. … Paulson H.L. (J. Biol. Chem. 2013) 3 4 64
  2. Ube2W conjugates ubiquitin to I+-amino groups of protein N-termini. (PMID: 23560854) Tatham M.H. … Hay R.T. (Biochem. J. 2013) 3 4 64
  3. UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. (PMID: 21229326) Zhang Y. … Huang P. (Mol. Cells 2011) 3 4 64
  4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4 64
  5. Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. (PMID: 19111657) Alpi A.F. … Patel K.J. (Mol. Cell 2008) 3 4 64

Products for UBE2W Gene

  • Addgene plasmids for UBE2W

Sources for UBE2W Gene

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