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Aliases & Descriptions for UBE2W
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 6.3.2.19 3 FLJ11011 1 , 2 hUBC-16 2
Descriptions Ubiquitin carrier protein W 3 Ubiquitin-protein ligase W 3 ubiquitin-conjugating enzyme 16 2 ubiquitin-conjugating enzyme E2W (putative) 2
Search outside databases for aliases for UBE2W gene
Summaries for UBE2W (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02 Function : Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
Genomic Location for UBE2W
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the UBE2W gene Entrez Gene cytogenetic band: 8q21.11 Ensembl cytogenetic band: 8q21.11 HGNC cytogenetic band: 8q21.11 UBE2W Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure
GeneLoc location for GC08M074866:
(about GC identifiers )
Start:
74,865,394 bp from pter
End:
74,953,664 bp from pter
Size:
88,271 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000008.9 NT_008183.18 Proteins for UBE2W
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02 (See
protein sequence )Recommended Name: Probable ubiquitin-conjugating enzyme E2 W Size : 151 amino acids; 17331 Da
Subunit : Homodimer
PDB structures from and Proteopedia : 2A7L (3D)
 
Secondary accessions : Q9H823 Q9HAG6 Q9NV07Alternative splicing : 2 isoforms : Q96B02-1 Q96B02-2
REFSEQ proteins (2 alternative transcripts):
NP_001001481.1 NP_060769.3 ENSEMBL proteins: ENSP00000351607 ENSP00000382398 ENSP00000355382 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: UBE2W Antibodies for UBE2W: Assays for UBE2W:
Protein
Domains/ Families for UBE2W(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96B02 ProtoNet protein and cluster: Q96B02
1 Blocks protein family : IPB000608 Ubiquitin-conjugating enzymes UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02 Similarity : Belongs to the ubiquitin-conjugating enzyme family
Gene Function for UBE2W
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_018299 Applied Biosystems Silencer ® siRNAs for UBE2W Sigma-Aldrich siRNA and siRNA Panels for UBE2W Sigma-Aldrich shRNA Panels and shRNA for UBE2W Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001001481                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001001481                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC010900  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001001481 UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02 Function : Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)Catalytic activity : ATP + ubiquitin + protein lysine = AMP + diphosphate + proteinN-ubiquityllysine Enzyme Number (IUBMB): EC 6.3.2.19
2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004842 ubiquitin-protein ligase activity
IEA -- GO:0016874 ligase activity
IEA --
About this table
Pathways & Interactions for UBE2W
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02 Pathway : Protein modification; protein ubiquitination
3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0019941 modification-dependent protein catabolic process
IEA -- GO:0043687 post-translational protein modification
IEA -- GO:0051246 regulation of protein metabolic process
IEA --
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Drugs & Compounds for UBE2W (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for UBE2W
Transcripts for UBE2W(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
OriGene , Expression Assays from Applied Biosystems )About This Section
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4 ): NM_018299 Sigma-Aldrich siRNA and siRNA Panels for UBE2W Sigma-Aldrich shRNA Panels and shRNA for UBE2W Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001001481 NM_018299
REFSEQ mRNAs for UBE2W gene (2 alternative transcripts): NM_001001481.1 NM_018299.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001001481 NM_018299
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001001481                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001001481                                  untagged cDNA clones in CMV expression vector (see all 4 ): BC010900  
Additional cDNA sequence: AK001873.1 AK021735.1 AK024050.1 AK225554.1 AK295792.1 AL833723.1 AY948289.1 BC010900.1 BC016326.1 BX538145.1 BX648427.1 CR457275.1 CR597814.1 CR609430.1
8 DOTS entries : DT.100821509 DT.212257 DT.100640421 DT.102842 DT.95375728 DT.212259 DT.100821506 DT.65287833
24/446 AceView cDNA sequences (see all 446
):AU133836 NM_018299 CA311807 BC071766 AI040886 D25755 AV709525 AK002152 BX399252 BQ082747 AI290456 AI741718 BQ000367 CR597814 AA252578 BQ220156 AW235263 BM979176 AL705155 NM_001001482 Z40600 BX538145 Z40558 AI768561
highest scoring ESTs for UBE2W :AA620611 AI625741 AK001873 AK021735 AK024050 AL710166 AU143505 BC016326 BG426710 BI547963
Unigene Cluster for UBE2W: Ubiquitin-conjugating enzyme E2W (putative) Hs.597486 [show with all ESTs ] Unigene Representative Sequence: NM_001001481 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2W ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b SP1 :                   SP2 :     -               SP3 :     -     -          
About this scheme ECgene alternative splicing isoforms for UBE2W 3 Ensembl transcripts including schematic representations : ENST00000358757
ENST00000399473
ENST00000362030
Expression for UBE2W
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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UBE2W expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for UBE2W 1 / 2 / 3
11 probe-sets matching UBE2W gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.597486
Orthologs for UBE2W
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for UBE2W gene from 5/12 species (see all 12
)
About this table Species with no ortholog for UBE2W ENSEMBL Gene Tree for UBE2W Paralogs for UBE2W (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for UBE2W gene UBE2R2 2 CDC34 2
SNPs/Variants for UBE2W (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for UBE2W (up to first 250kb)
Disorders & Mutations for UBE2W
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for UBE2W (Possibly Related Articles in
Doctor's Guide )
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--
Publications for UBE2W (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for UBE2W gene :
Search for UBE2W
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing UBE2W
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing UBE2W
(According to HUGE )
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Specialized Databases showing UBE2W (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for UBE2W (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for UBE2W:
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