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UBE2W Gene

protein-coding   GIFtS: 55
GCID: GC08M074692

Ubiquitin-Conjugating Enzyme E2W (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2W (Putative)1 2     UBC-162 3
UBC162 3 5     N-Terminus-Conjugating E22 3
Ubiquitin Carrier Protein W2 3     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme 162 3     Ubiquitin-Conjugating Enzyme 2W2
Ubiquitin-Protein Ligase W2 3     Ubiquitin-Conjugating Enzyme E2 W2

External Ids:    HGNC: 256161   Entrez Gene: 552842   Ensembl: ENSG000001043437   OMIM: 6142775   UniProtKB: Q96B023   

Export aliases for UBE2W gene to outside databases

Previous GC identifers: GC08M074866 GC08M074702 GC08M070193


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2W Gene:
This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1)
and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded
protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the
repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Aug 2012)

GeneCards Summary for UBE2W Gene:
UBE2W (ubiquitin-conjugating enzyme E2W (putative)) is a protein-coding gene. Diseases associated with UBE2W include fanconi's anemia, and malaria. GO annotations related to this gene include ubiquitin-protein ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is ENSG00000258677.

UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of
STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of
ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC)
treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with
E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage
pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box
type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and
preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2W gene promoter:
         STAT5B   AML1a   HNF-4alpha2   STAT5A   Egr-4   HNF-4alpha1   GATA-1   AREB6   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2W promoter sequence
   Search Chromatin IP Primers for UBE2W

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2W


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q21.11   Ensembl cytogenetic band:  8q21.11   HGNC cytogenetic band: 8q21.11

UBE2W Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2W gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M074692:  view genomic region     (about GC identifiers)

Start:
74,692,332 bp from pter      End:
74,791,145 bp from pter
Size:
98,814 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 W  
Size: 151 amino acids; 17331 Da
Subunit: Homodimer. Interacts with FANCL. Interacts with STUB1/CHIP (By similarity)
1 PDB 3D structure from and Proteopedia for UBE2W:
2A7L (3D)    
Secondary accessions: B4DIV1 Q1XBE0 Q9H823 Q9HAG6 Q9NV07
Alternative splicing: 3 isoforms:  Q96B02-1   Q96B02-2   Q96B02-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2W: NX_Q96B02

Explore proteomics data for UBE2W at MOPED

Post-translational modifications: 

  • Ubiquitinated in vitro in the presence of FANCL (By similarity). Autoubiquitinated at Met-11
  • Modification sites at neXtProt
  • 2 DME Specific Peptides for UBE2W (Q96B02)
     LSIISMLS  YSNGHICL 


    See UBE2W Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001481.2  NP_001257944.1  NP_060769.4  

    ENSEMBL proteins: 
     ENSP00000428835   ENSP00000428813   ENSP00000414771   ENSP00000397453   ENSP00000430254  
     ENSP00000429136   ENSP00000403764   ENSP00000473516   ENSP00000473561  
    Reactome Protein details: Q96B02

    UBE2W Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q96B02

    ProtoNet protein and cluster: Q96B02

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2W for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2W_HUMAN, Q96B02
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
    monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of
    STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of
    ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC)
    treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with
    E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage
    pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box
    type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and
    preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0031625ubiquitin protein ligase binding IPI19111657
         
    UBE2W for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2W:
     Increased number of cells in m 

    Animal Models:
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    miRNA
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    hsa-mir-132-3p (MIRT021759), hsa-mir-192-5p (MIRT026299), hsa-mir-142-3p (MIRT021613), hsa-mir-215-5p (MIRT024580), hsa-mir-32-5p (MIRT028282), hsa-mir-128-3p (MIRT021902)

    Block miRNA regulation of human, mouse, rat UBE2W using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2W (see all 171):
    hsa-miR-376b hsa-miR-631 hsa-miR-106a hsa-miR-199a-3p hsa-miR-938 hsa-miR-128 hsa-miR-138-2* hsa-miR-519a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBE2W_HUMAN, Q96B02: Nucleus. Note=In the nucleus, colocalizes with FANCL
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    UBE2W for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2W About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for UBE2W
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for UBE2W):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02
    Pathway: Protein modification; protein ubiquitination


    UBE2W for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2W: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBE2W

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2W (Q96B022, 3 ENSP000003974534) via UniProtKB, MINT, STRING, and/or I2D (see all 106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2CP193872, 3, ENSP000002192524MINT-63530 I2D: score=5 STRING: ENSP00000219252
    AKR1C3P423302, 3MINT-63740 I2D: score=5 
    DNMT3BQ9UBC32, 3MINT-8276321 I2D: score=2 
    EEDO755302, 3MINT-8276332 I2D: score=2 
    ENSG00000224994Q9HCM93, ENSP000004119494I2D: score=2 STRING: ENSP00000411949
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006513protein monoubiquitination IMP--
    GO:0006515misfolded or incompletely synthesized protein catabolic process ISS--
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process ISS--
    GO:0070979protein K11-linked ubiquitination IDA--

    UBE2W for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UBE2W

    4 HMDB Compounds for UBE2W    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBE2W gene (4 alternative transcripts): 
    NM_001001481.2  NM_001271015.1  NM_018299.4  NM_001001482.1  

    Unigene Cluster for UBE2W:

    Ubiquitin-conjugating enzyme E2W (putative)
    Hs.128841  [show with all ESTs]
    Unigene Representative Sequence: NM_001001481
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523278 ENST00000517608(uc003xzu.3 uc003xzv.3) ENST00000422906(uc003xzw.3)
    ENST00000419880 ENST00000519277 ENST00000519255 ENST00000453587(uc003xzt.2)
    ENST00000602969 ENST00000602593
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    hsa-miR-376b hsa-miR-631 hsa-miR-106a hsa-miR-199a-3p hsa-miR-938 hsa-miR-128 hsa-miR-138-2* hsa-miR-519a
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    Additional mRNA sequence: 

    AK001873.1 AK021735.1 AK024050.1 AK123531.1 AK225554.1 AK295792.1 AL833723.1 AY948289.1 
    BC010900.1 BC016326.1 BX538145.1 BX648427.1 CR457275.1 NR_073119.1 NR_073120.1 NR_073121.1 

    12 DOTS entries:

    DT.100640421  DT.100821509  DT.212257  DT.102842  DT.75189561  DT.40127576  DT.95375728  DT.100821506 
    DT.65287833  DT.95315344  DT.212259  DT.40250693 

    Selected AceView cDNA sequences (see all 446):

    CA448076 BM718979 AA226963 BM677613 NM_001001482 BM272995 BQ000367 BM979176 
    BM848589 CA312778 BM836010 BM704494 BF448938 BQ082747 AI301037 CD104313 
    AV709525 AA196389 AU133836 BI792408 AL079288 BQ067641 BM818932 AI802880 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2W    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                                      
    SP2:              -                                       
    SP3:              -           -                           


    ECgene alternative splicing isoforms for UBE2W

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2W expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UBE2W Expression
    About this image

    UBE2W Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2W Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.128841

    UniProtKB/Swiss-Prot: UBE2W_HUMAN, Q96B02
    Tissue specificity: Widely expressed, with highest expression in brain, liver, pancreas and heart

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2W: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2W

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2W gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2w1 , 5 ubiquitin-conjugating enzyme E2W (putative)1, 5 94.07(n)1
    95.56(a)1
      1 (5.10 cM)5
    667991  NM_025773.31  NP_080049.21 
     165407905 
    chicken
    (Gallus gallus)
    Aves UBE2W1 ubiquitin-conjugating enzyme E2W (putative) 90.95(n)
    99.34(a)
      420185  NM_001199481.1  NP_001186410.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.199992 Transcribed sequence with strong similarity to protein more 85.94(n)    AL890226.2 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.176652 Danio rerio clone RK115A3B02 hypothetical protein FLJ11 more 83.05(n)    AY398346.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72201 CG7220 65.07(n)
    72.6(a)
      36129  NM_165795.3  NP_724964.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-161 ubc-16 58.85(n)
    61.38(a)
      173354  NM_061186.4  NP_493587.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC116
    Ubiquitin-conjugating enzyme most similar in seque...
    28(a)
    1 → many
    XV(958362-958832) YOR339C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC161 UBC16 59.71(n)
    53.96(a)
      843880  NM_106198.4  NP_565110.1 


    ENSEMBL Gene Tree for UBE2W (if available)
    TreeFam Gene Tree for UBE2W (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2W gene
    ENSG000002586772  UBE2C2  
    15 SIMAP similar genes for UBE2W using alignment to 5 protein entries:     UBE2W_HUMAN (see all proteins):
    UBE2M    UBE2N    UBE2E3    UBE2E2    UBE2E1    UBE2B
    HR6A    UBE2A    UBE2D4    UBE2C    UBE2D2    UBE2D3
    UBE2I    UBE2D1    UBE2L6

    UBE2W for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBE2W
    PGOHUM00000259569


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2W (see all 2013)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1418288791,2
    --74691847(+) AAGAAA/TTGTTT 1 -- ds50010--------
    rs1125236501,2
    C,F--74691855(+) TTTTTT/CGAGCT 1 -- ds50012Minor allele frequency- C:0.21CSA WA 120
    rs1506274601,2
    --74691929(+) CTCACA/GTGTGC 1 -- ds50010--------
    rs767175961,2
    C,F--74691951(+) CTGCAT/CGAAAC 1 -- ds50012Minor allele frequency- C:0.21CSA WA 120
    rs733226311,2
    C,F--74692097(+) CTTGAC/ACCTAC 1 -- ds50015Minor allele frequency- A:0.09WA CSA EA 244
    rs1840614971,2
    --74692130(+) AAAATC/GTATCA 1 -- ds50010--------
    rs1422385991,2
    C--74692150(+) CCAGT-/AAAGGA
            
    AATGT
    1 -- ds50010--------
    rs1439023581,2
    --74692284(+) ATAGTA/GTGTGT 1 -- ds50010--------
    rs766520311,2
    C,F--74692333(+) GGATGA/CCTTAA 1 -- ut312Minor allele frequency- C:0.21CSA WA 120
    rs1887434161,2
    --74692367(+) CACAGA/TTCTGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2W (74692332 - 74791145 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for UBE2W:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2678738CNV Deletion23128226
    esv2737169CNV Deletion23290073
    esv2737170CNV Deletion23290073
    esv1048357CNV Deletion17803354
    nsv471760CNV Loss16327809

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2W
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2W

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614277    OMIM disorders: --

    2 diseases for UBE2W:    
    About MalaCards
    fanconi's anemia    malaria


    UBE2W for disorders           About GeneDecksing


    Export disorders for UBE2W gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2W gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with UBE2W)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ube2W conjugates ubiquitin to I+-amino groups of protein N-termini. (PubMed id 23560854)1, 2 Tatham M.H....Hay R.T. (Biochem. J. 2013)
    2. The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates. (PubMed id 23696636)1, 2 Scaglione K.M....Paulson H.L. (J. Biol. Chem. 2013)
    3. UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. (PubMed id 21229326)1, 2 Zhang Y.... Huang P. (Mol. Cells 2011)
    4. Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. (PubMed id 19111657)1, 2 Alpi A.F.... Patel K.J. (Mol. Cell 2008)
    5. Cloning, characterization and subcellular localization of a gene encoding a human Ubiquitin-conjugating enzyme (E2) homologous to the Arabidopsis thaliana UBC-16 gene product. (PubMed id 16368532)1, 2 Yin G.... Mao Y. (Front. Biosci. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PubMed id 17873885)1, 9 Christensen D.E.... Klevit R.E. (Nat. Struct. Mol. Biol. 2007)
    10. Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis. (PubMed id 23509263)1 Starita L.M....Klevit R.E. (Proc. Natl. Acad. Sci. U.S.A. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55284 HGNC: 25616 AceView: STAU2andFLJ11011 Ensembl:ENSG00000104343 euGenes: HUgn55284
    ECgene: UBE2W Kegg: 55284 H-InvDB: UBE2W

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2W Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2W gene:
    Search GeneIP for patents involving UBE2W

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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