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Aliases for UBE2W Gene

Aliases for UBE2W Gene

  • Ubiquitin-Conjugating Enzyme E2W (Putative) 2 3
  • N-Terminal E2 Ubiquitin-Conjugating Enzyme 3 4
  • E2 Ubiquitin-Conjugating Enzyme W 3 4
  • Ubiquitin-Conjugating Enzyme 16 3 4
  • Ubiquitin Carrier Protein W 3 4
  • Ubiquitin-Protein Ligase W 3 4
  • N-Terminus-Conjugating E2 3 4
  • UBC-16 3 4
  • UBC16 3 4
  • Ubiquitin-Conjugating Enzyme 2W 3
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • EC 2.3.2.25 4

External Ids for UBE2W Gene

Previous GeneCards Identifiers for UBE2W Gene

  • GC08M074866
  • GC08M074702
  • GC08M070193
  • GC08M074692

Summaries for UBE2W Gene

Entrez Gene Summary for UBE2W Gene

  • This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for UBE2W Gene

UBE2W (Ubiquitin-Conjugating Enzyme E2W (Putative)) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2C.

UniProtKB/Swiss-Prot for UBE2W Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes Lys-11-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2W Gene

Genomics for UBE2W Gene

Regulatory Elements for UBE2W Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2W Gene

Chromosome:
8
Start:
73,780,097 bp from pter
End:
73,878,910 bp from pter
Size:
98,814 bases
Orientation:
Minus strand

Genomic View for UBE2W Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2W Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2W Gene

Proteins for UBE2W Gene

  • Protein details for UBE2W Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B02-UBE2W_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 W
    Protein Accession:
    Q96B02
    Secondary Accessions:
    • B4DIV1
    • Q1XBE0
    • Q9H823
    • Q9HAG6
    • Q9NV07

    Protein attributes for UBE2W Gene

    Size:
    151 amino acids
    Molecular mass:
    17331 Da
    Quaternary structure:
    • Homodimer. Interacts with FANCL (Ref.7). Interacts with STUB1/CHIP (By similarity).

    Three dimensional structures from OCA and Proteopedia for UBE2W Gene

    Alternative splice isoforms for UBE2W Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2W Gene

Proteomics data for UBE2W Gene at MOPED

Selected DME Specific Peptides for UBE2W Gene

Post-translational modifications for UBE2W Gene

  • Ubiquitinated in vitro in the presence of FANCL (By similarity). Autoubiquitinated at Met-1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UBE2W Gene

Gene Families for UBE2W Gene

Protein Domains for UBE2W Gene

Graphical View of Domain Structure for InterPro Entry

Q96B02

UniProtKB/Swiss-Prot:

UBE2W_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2W: view

Function for UBE2W Gene

Molecular function for UBE2W Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-N-terminal-amino acid = [E1 ubiquitin-activating enzyme]-L-cysteine + N-terminal-ubiquitinyl-[acceptor protein].
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes Lys-11-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.

Enzyme Numbers (IUBMB) for UBE2W Gene

Gene Ontology (GO) - Molecular Function for UBE2W Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 21229326
GO:0005515 protein binding IPI 19549727
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity --
GO:0031625 ubiquitin protein ligase binding IPI 19111657
genes like me logo Genes that share ontologies with UBE2W: view
genes like me logo Genes that share phenotypes with UBE2W: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2W

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2W Gene

Localization for UBE2W Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2W Gene

Nucleus. Note=In the nucleus, colocalizes with FANCL.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2W Gene COMPARTMENTS Subcellular localization image for UBE2W gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for UBE2W Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBE2W: view

Pathways & Interactions for UBE2W Gene

genes like me logo Genes that share pathways with UBE2W: view

Pathways by source for UBE2W Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat

UniProtKB/Swiss-Prot Q96B02-UBE2W_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2W Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006513 protein monoubiquitination IMP 21229326
GO:0006515 misfolded or incompletely synthesized protein catabolic process ISS --
GO:0016567 protein ubiquitination --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS --
genes like me logo Genes that share ontologies with UBE2W: view

No data available for SIGNOR curated interactions for UBE2W Gene

Drugs & Compounds for UBE2W Gene

(3) Drugs for UBE2W Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2W Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2W: view

Transcripts for UBE2W Gene

Unigene Clusters for UBE2W Gene

Ubiquitin-conjugating enzyme E2W (putative):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2W

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2W Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1:
SP2: -
SP3: - -

Relevant External Links for UBE2W Gene

GeneLoc Exon Structure for
UBE2W
ECgene alternative splicing isoforms for
UBE2W

Expression for UBE2W Gene

mRNA expression in normal human tissues for UBE2W Gene

Protein differential expression in normal tissues from HIPED for UBE2W Gene

This gene is overexpressed in Testis (37.6), Pancreas (17.3), and Prostate (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBE2W Gene



SOURCE GeneReport for Unigene cluster for UBE2W Gene Hs.128841

mRNA Expression by UniProt/SwissProt for UBE2W Gene

Q96B02-UBE2W_HUMAN
Tissue specificity: Widely expressed, with highest expression in brain, liver, pancreas and heart.
genes like me logo Genes that share expression patterns with UBE2W: view

Protein tissue co-expression partners for UBE2W Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBE2W Gene

Orthologs for UBE2W Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2W Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2W 35
  • 98.23 (n)
  • 100 (a)
UBE2W 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia UBE2W 35
  • 96.67 (n)
  • 97.78 (a)
-- 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ube2w 35
  • 94.07 (n)
  • 95.56 (a)
Ube2w 16
Ube2w 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2W 35
  • 99.62 (n)
  • 99.44 (a)
UBE2W 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2wl 35
  • 94.75 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 96 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves UBE2W 35
  • 90.95 (n)
  • 99.34 (a)
UBE2W 36
  • 98 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19999 35
ube2w 35
  • 86.09 (n)
  • 98.68 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17665 35
flj11011l 35
  • 84.11 (n)
  • 96.69 (a)
flj11011l 36
  • 91 (a)
ManyToMany
ube2w 36
  • 90 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005324 35
  • 66.89 (n)
  • 71.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7220 35
  • 65.07 (n)
  • 72.6 (a)
CG7220 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-16 35
  • 58.85 (n)
  • 61.38 (a)
ubc-16 36
  • 59 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC11 36
  • 28 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC16 35
  • 59.71 (n)
  • 53.96 (a)
Species with no ortholog for UBE2W:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2W Gene

ENSEMBL:
Gene Tree for UBE2W (if available)
TreeFam:
Gene Tree for UBE2W (if available)

Paralogs for UBE2W Gene

Paralogs for UBE2W Gene

Pseudogenes.org Pseudogenes for UBE2W Gene

genes like me logo Genes that share paralogs with UBE2W: view

Variants for UBE2W Gene

Sequence variations from dbSNP and Humsavar for UBE2W Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs967555 -- 73,870,852(+) GGAAG(A/C)CATCC intron-variant
rs1059191 -- 73,790,771(-) TACAT(A/G)TTACT utr-variant-3-prime, intron-variant, nc-transcript-variant
rs1277875 -- 73,849,593(+) AAAAC(A/T)GAAAA intron-variant
rs1277876 -- 73,852,175(+) ACATT(C/G)AGATT intron-variant
rs1298789 -- 73,849,496(+) aacaa(A/G)agtga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2W Gene

Variant ID Type Subtype PubMed ID
esv2678738 CNV Deletion 23128226
esv2737169 CNV Deletion 23290073
esv2737170 CNV Deletion 23290073
nsv471760 CNV Loss 16327809
esv1048357 CNV Deletion 17803354

Variation tolerance for UBE2W Gene

Gene Damage Index Score: 2.33; 41.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2W Gene

HapMap Linkage Disequilibrium report
UBE2W

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2W Gene

Disorders for UBE2W Gene

Relevant External Links for UBE2W

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2W
genes like me logo Genes that share disorders with UBE2W: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2W Gene

Publications for UBE2W Gene

  1. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PMID: 17873885) Christensen D.E. … Klevit R.E. (Nat. Struct. Mol. Biol. 2007) 23 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  3. Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. (PMID: 25527291) Wauer T. … Komander D. (EMBO J. 2015) 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. Intrinsic disorder drives N-terminal ubiquitination by Ube2w. (PMID: 25436519) Vittal V. … Klevit R.E. (Nat. Chem. Biol. 2015) 67

Products for UBE2W Gene

Sources for UBE2W Gene

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