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UBE2V2 Gene

protein-coding GIFtS: 65

GC08P049083

ubiquitin-conjugating enzyme E2 variant 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DDVIT1 ^²
DDVit-1 ^¹, ²
EDAF-1 ^²
EDPF-1 ^¹, ², ³
EDPF1 ^²
MMS2 ^¹, ², ³
UEV-2 ^¹, ²
UEV2 ^², ³

Descriptions
1 alpha,25-dihydroxyvitamin D3-inducible ^²
DDVit 1 ^³
Enterocyte differentiation-associated factor EDAF-1 ^³
Enterocyte differentiation-promoting factor ^³
Vitamin D3-inducible protein ^³
enterocyte differentiation promoting factor ^²
methyl methanesulfonate sensitive 2, S. cerevisiae, homolog of ^²
ubiquitin-conjugating enzyme E2 variant 2 ^²
ubiquitin-conjugating enzyme E2v2 ^²

External Ids
HGNC: 12495¹
Entrez Gene: 7336²
UniProtKB: Q15819³
Ensembl: ENSG00000169139⁷

Search outside databases for aliases for UBE2V2 gene

Previous GC identifers: GC08P048012 GC08P048925 GC08P048644 GC08P048970

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2V2:

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2

protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the

conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded

by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2

gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by

RefSeq]

UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819

Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the

synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of

poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates

transcriptional activation of target genes. Plays a role in the control of progress through the

cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes

to the survival of cells after DNA damage

Gene Wiki entry for UBE2V2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2V2 gene

Entrez Gene cytogenetic band: 8q11.21 Ensembl cytogenetic band: 8q11.21 HGNC cytogenetic band: 8q11.21

UBE2V2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P049083: (about GC identifiers)

Start:	49,083,548 bp from pter
End:	49,137,007 bp from pter
Size:	53,460 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 variant 2

Size: 145 amino acids; 16363 Da

Subunit: Heterodimer with UBE2N. Binds CHFR

PDB structures from and Proteopedia :

1J74 (3D)

1J7D (3D)

1ZGU (3D)

REFSEQ proteins: NP_003341.1

ENSEMBL proteins:

ENSP00000326473

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBE2V2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2V2
	Recombinant Proteins from Abcam (UBE2V2 +UBE2V1, UEV2)
	Human Recombinant Proteins from Abnova (UBE2V2)

OriGene Purified Recombinant Human Protein: UBE2V2

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16129784
GO:0005737	cytoplasm	TAS	16129784
GO:0031372	UBC13-MMS2 complex	IDA	16129784

About this table

Antibodies for UBE2V2:

	Invitrogen Antibodies for UBE2V2
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE2V2 +UBE2V1, UEV2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2V2)
	Novus Biologicals Antibodies for UBE2V2

Assays for UBE2V2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2V2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q15819

ProtoNet protein and cluster: Q15819

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2V2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2V2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003350

Applied Biosystems Silencer® siRNAs for UBE2V2

Sigma-Aldrich siRNA and siRNA Panels for UBE2V2

Sigma-Aldrich shRNA Panels and shRNA for UBE2V2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2V2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003350
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003350
untagged cDNA clone in CMV expression vector: NM_003350

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003350

UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819

Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the

synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of

poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates

transcriptional activation of target genes. Plays a role in the control of progress through the

cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes

to the survival of cells after DNA damage

Induction: Up-regulated in cultured fresh blood cells upon treatment with vitamin D3

Genatlas biochemistry entry for UBE2V2:

ubiquitin conjugating enzyme E2 variant 2,expressed in monocytes and in some cancer

lines,putatively involved in the control of differentiation

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	11473255 16786304
GO:0019787	small conjugating protein ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2V2 (Your Favorite Gene powered by Ingenuity)

Hypoxia Signaling in the Cardiovascular System
Protein Ubiquitination Pathway

GeneDecks UBE2V2 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2V2

5/19 Interacting proteins for UBE2V2 (Q15819^{1, 2} ENSP00000326473³) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2N	P61088¹, ENSP00000316176³	EBI-714329, EBI-1052908 STRING (score=.999)
UBC35 UBC35 (xeno)	Q94A97¹	EBI-714329, EBI-994120
IGSF21	Q96ID5²	MINT-64269
MOBKL3	Q9Y3A3²	MINT-65831
PCNA	ENSP00000368438³	STRING (score=.984)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	TAS	10089880
GO:0000729	DNA double-strand break processing	IMP	17349954
GO:0006282	regulation of DNA repair	TAS	10089880
GO:0008283	cell proliferation	TAS	9418904
GO:0019941	modification-dependent protein catabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2V2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2V2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2V2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003350

Sigma-Aldrich siRNA and siRNA Panels for UBE2V2

Sigma-Aldrich shRNA Panels and shRNA for UBE2V2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003350

REFSEQ mRNAs for UBE2V2 gene:

NM_003350.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003350

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003350
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003350
                                 untagged cDNA clone in CMV expression vector: NM_003350

Additional cDNA sequence:

AF049140.1 AK094617.1 AK313447.1 BC007051.1 BC016332.1 BC016710.1 BC028673.1 BC062418.1

BT006744.1 CR407628.1 CR603464.1 CR603543.1 U62136.2 X98091.1

24/25 DOTS entries (see all 25 ):

DT.92468578 DT.99975199 DT.92468536 DT.310202 DT.91999321 DT.92468530 DT.100827881 DT.100827885

DT.92468535 DT.100827883 DT.95284972 DT.100827884 DT.100827877 DT.121485744 DT.121485844 DT.121485861

DT.92468588 DT.95284962 DT.95284984 DT.100827873 DT.121485750 DT.95284971 DT.95284988 DT.99980382

24/1109 AceView cDNA sequences (see all 1109 ):

BE698527 AI055876 AV708041 AW246621 BE504258 BM833841 BM719387 BF589541

AW024676 CA441431 AI253060 BU567372 BE698521 BU677186 BP347509 AI202679

F11561 BU508785 AI763271 BU928473 CB127259 AA776914 BM477255 BG533577

highest scoring ESTs for UBE2V2:

AF049140 AA071363 AA102842 AA102843 AA129335 AA148454 AA148455 AA160935 AA164942 AA195549

Unigene Cluster for UBE2V2:

Ubiquitin-conjugating enzyme E2 variant 2

Hs.491695 [show with all ESTs]

Unigene Representative Sequence: AK094617

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2V2

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	·	5c
SP1:
SP2:									-
SP3:					-				-

About this scheme

ECgene alternative splicing isoforms for UBE2V2

1 Ensembl transcript including schematic representation:

ENST00000324746

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2V2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2V2

¹ / ² / ³

3 probe-sets matching UBE2V2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37750_at²^{, 3}	U95-A	1	0.56	1.00	1.00	1.00	AF049140	1.00	1.00	1.00	1
209096_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U62136	0.80	1.00	0.91	1
209096_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CATTTAAGTT

SOURCE GeneReport for Unigene cluster: Hs.491695
Expression variation in blood from EXPOLDB for UBE2V2
UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819
Tissue specificity: Detected in placenta, colon, liver and skin. Detected at very low levels in
most tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2V2 gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2V2¹	--	ubiquitin-conjugating enzyme E2 variant 2	96.55(n) 97.24(a)	612943 XM_847910.1 XP_853003.1
chimpanzee (Pan troglodytes)	UBE2V2¹	--	ubiquitin-conjugating enzyme E2 variant 2	99.52(n) 100(a)	740505 XM_001142548.1 XP_001142548.1
cow (Bos taurus)	UBE2V2¹	--	ubiquitin-conjugating enzyme E2 variant 2	95.86(n) 100(a)	286803 NM_001034042.1 NP_001029214.1
rat (Rattus norvegicus)	Ube2v2¹	--	ubiquitin-conjugating enzyme E2 variant 2	94.48(n) 99.31(a)	287927 NM_183052.1 NP_898875.1
mouse (Mus musculus)	Ube2v2^{1, 5}	16⁵	ubiquitin-conjugating enzyme E2 variant 2^{1, 5}	95.17(n)¹ 98.62(a)¹	70620¹ NM_023585.3¹ NP_076074.2¹ AF303828⁵ AI848315⁵ (see all 25)

About this table Species with no ortholog for UBE2V2

ENSEMBL Gene Tree for UBE2V2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2V2 gene

TMEM189²

Pseudogenes

8 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/182 NCBI SNPs in UBE2V2 are shown (see all 182 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 21)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10808897^1,2	A,C,F,H	49137169(+)	`GAAAAG/TTCATT`	1	--	ng3¹		17	EU EA WA NA NS	1382
--	rs28578331^1,2	C,F	49083096(+)	`AGTGGC/TGCAAT`	1	--	ng5¹		5	NS	190
	rs28542480^1,2	C,F	49083499(+)	`GCGGCG/TCGCTC`	1	--	ng5¹		5	NS	178
--	rs28699569^1,2	C,F	49083224(+)	`GAGACG/AGGGTT`	1	--	ng5¹		5	NS	188
--	rs11557789^1,2	H	49125030(+)	`AGCTCC/TTCCGT`	1	P/L	mis¹		4	EU EA WA	406
--	rs14890^1,2	H	49118247(+)	`ATGAAG/CATATG`	1	H/D	mis¹		4	EU EA WA	402
--	rs11557776^1,2	H	49118236(+)	`CCTTGA/GAGATG`	1	E/G	mis¹		4	EU EA WA	406
--	rs11557781^1,2	H	49135832(+)	`ATGGCA/GAAATT`	1	Q/R	mis¹		4	EU EA WA	406
--	rs11557778^1,2	H	49125050(+)	`TTGTAA/GCAAAA`	1	T/A	mis¹		4	EU EA WA	394
	rs2382637^1,2	H	49137321(+)	`ATTTTG/TTCAAG`	1	--	ng3¹		4	EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for UBE2V2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603001

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/28 PubMed articles for UBE2V2 gene (see all 28 ):

Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. (PubMed id 9199207)^{2, 3, 4} Fritsche J....Kreutz M. (1997)
The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. (PubMed id 9705497)^{1, 3, 4} Xiao W.... Wei Y.-F. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. (PubMed id 14562038)^{3, 4} Bothos J.... Halazonetis T.D. (2003)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. (PubMed id 11473255)^{3, 4} Moraes T.F.... Ellison M.J. (2001)
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. (PubMed id 10089880)^{3, 4} Hofmann R.M. and Pickart C.M. (1999)
Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PubMed id 9418904)^{2, 3} Sancho E.... Thomson T.M. (1998)
Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States. (PubMed id 15952783)^{1, 3} Spyracopoulos L....Saltibus L.F. (2005)
UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40. (PubMed id 15725630)^{1, 3} Simpson L.J. and Sale J.E. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7336	HGNC: 12495	AceView: UBE2V2	Ensembl:ENSG00000169139	euGenes: HUgn7336
ECgene: UBE2V2	H-InvDB: UBE2V2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for UBE2V2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE2V2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE2V2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2V2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for UBE2V2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE2V2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Antibodies (UBE2V2 +UBE2V1, UEV2)

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	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for UBE2V2

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UBE2V2 Gene

protein-coding GIFtS: 65

Aliases &
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for UBE2V2

Proteins
for UBE2V2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2V2 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor UBE2V2

Summariesfor UBE2V2

Genomic Locationfor UBE2V2

Proteinsfor UBE2V2

Protein Domains/Familiesfor UBE2V2

Gene Functionfor UBE2V2

Pathways & Interactionsfor UBE2V2

Drugs & Compoundsfor UBE2V2

Transcriptsfor UBE2V2

Expression for UBE2V2

Orthologsfor UBE2V2

Paralogsfor UBE2V2

SNPs/Variantsfor UBE2V2

Disorders & Mutationsfor UBE2V2

Medical Newsfor UBE2V2

Publicationsfor UBE2V2

Search for UBE2V2

Genome Databases showing UBE2V2

Other Databases showing UBE2V2

Specialized Databases showing UBE2V2

Licensable Technologiesfor UBE2V2

Servicesfor UBE2V2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2V2

Summaries
for UBE2V2

Genomic Location
for UBE2V2

Proteins
for UBE2V2

Protein Domains/
Families
for UBE2V2

Gene Function
for UBE2V2

Pathways & Interactions
for UBE2V2

Drugs & Compounds
for UBE2V2

Transcripts
for UBE2V2

Expression
for UBE2V2

Orthologs
for UBE2V2

Paralogs
for UBE2V2

SNPs/Variants
for UBE2V2

Disorders & Mutations
for UBE2V2

Medical News
for UBE2V2

Publications
for UBE2V2

Licensable Technologies
for UBE2V2

Services
for UBE2V2