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UBE2V2 Gene

protein-coding   GIFtS: 65
GCID: GC08P048920

Ubiquitin-Conjugating Enzyme E2 Variant 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2 Variant 21 2     MMS2 Homolog2 3
MMS22 3 5     DDVIT12 5
UEV22 3 5     EDPF12 5
Enterocyte Differentiation-Associated Factor 12 3     1 Alpha,25-Dihydroxyvitamin D3-Inducible2
Enterocyte Differentiation-Promoting Factor 12 3     DDVit-12
Vitamin D3-Inducible Protein2 3     UEV-22
EDAF-12 3     Enterocyte Differentiation Promoting Factor2
EDPF-12 3     Enterocyte Differentiation-Associated Factor EDAF-12
DDVit 12 3     Methyl Methanesulfonate Sensitive 2, S. Cerevisiae, Homolog Of2

External Ids:    HGNC: 124951   Entrez Gene: 73362   Ensembl: ENSG000001691397   OMIM: 6030015   UniProtKB: Q158193   

Export aliases for UBE2V2 gene to outside databases

Previous GC identifers: GC08P048012 GC08P048925 GC08P048644 GC08P048970 GC08P049083 GC08P044383


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2V2 Gene:
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family.
They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that
is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with
ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation
of monocytes and enterocytes. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2V2 Gene:
UBE2V2 (ubiquitin-conjugating enzyme E2 variant 2) is a protein-coding gene. GO annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is UBE2V1.

UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819
Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of
non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not
lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role
in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair
pathway and contributes to the survival of cells after DNA damage

Gene Wiki entry for UBE2V2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008183.20  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2V2 gene promoter:
         Nkx3-1   Elk-1   Nkx3-1 v4   Nkx3-1 v1   CUTL1   HNF-1A   c-Ets-1   Nkx3-1 v2   NRF-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2V2 promoter sequence
   Search Chromatin IP Primers for UBE2V2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2V2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.21   Ensembl cytogenetic band:  8q11.21   HGNC cytogenetic band: 8q11.21

UBE2V2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2V2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P048920:  view genomic region     (about GC identifiers)

Start:
48,920,960 bp from pter      End:
48,977,268 bp from pter
Size:
56,309 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 variant 2  
Size: 145 amino acids; 16363 Da
Subunit: Heterodimer with UBE2N. Binds CHFR
5 PDB 3D structures from and Proteopedia for UBE2V2:
1J74 (3D)        1J7D (3D)        1ZGU (3D)        3VON (3D)        4EPO (3D)    

Explore the universe of human proteins at neXtProt for UBE2V2: NX_Q15819

Explore proteomics data for UBE2V2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys66, Lys72, Lys108, Lys129
  • Modification sites at PhosphoSitePlus

  • See UBE2V2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003341.1  
    ENSEMBL proteins: 
     ENSP00000428209   ENSP00000430019   ENSP00000428818   ENSP00000430491   ENSP00000429886  
     ENSP00000429419   ENSP00000430741  
    Reactome Protein details: Q15819

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q15819

    ProtoNet protein and cluster: Q15819

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2V2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2V2_HUMAN, Q15819
    Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of
    non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not
    lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role
    in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair
    pathway and contributes to the survival of cells after DNA damage
    Induction: Up-regulated in cultured fresh blood cells upon treatment with vitamin D3

         Genatlas biochemistry entry for UBE2V2:
    ubiquitin conjugating enzyme E2 variant 2,expressed in monocytes and in some cancer lines,putatively involved in
    the control of differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11473255
    GO:0016881acid-amino acid ligase activity IEA--
         
    Find genes that share ontologies with UBE2V2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2V2:
     Increased cell death in breast 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UBE2V2

    miRNA
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    miRTarBase miRNAs that target UBE2V2:
    hsa-mir-26b-5p (MIRT029206), hsa-mir-192-5p (MIRT026382), hsa-let-7e-5p (MIRT051590), hsa-mir-215-5p (MIRT024376)

    Block miRNA regulation of human, mouse, rat UBE2V2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2V2 (see all 26):
    hsa-miR-411* hsa-miR-30c hsa-miR-3607-3p hsa-miR-379* hsa-miR-30d hsa-miR-340 hsa-miR-3923 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidUBE2V2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol3
    mitochondrion2
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16129784
    GO:0005737cytoplasm TAS16129784
    GO:0031372UBC13-MMS2 complex IDA16129784

    Find genes that share ontologies with UBE2V2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2V2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    2Immune response NFAT in immune response
    Immune response T cell receptor signaling pathway0.50
    3Inactivation of APC/C via direct inhibition of the APC/C complex
    Common schema of ubiquitination0.33
    4Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    5Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions


    Find genes that share SuperPaths with UBE2V2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2V2
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for UBE2V2
        Immune response T cell receptor signaling pathway


    1 Reactome Pathway for UBE2V2
        Antigen processing: Ubiquitination & Proteasome degradation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBE2V2
    Interactions:

        GeneGlobe Interaction Network for UBE2V2

    Selected Interacting proteins for UBE2V2 (Q158191, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOB4Q9Y3A32, 3MINT-65831 I2D: score=5 
    IGSF21Q96ID52, 3MINT-64269 I2D: score=4 
    LRIF1Q5T3J32, 3MINT-64270 I2D: score=4 
    UBE2NP610881, 3EBI-714329,EBI-1052908 I2D: score=15 
    BCL10O959993I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS10089880
    GO:0000729DNA double-strand break processing IMP17349954
    GO:0006282regulation of DNA repair TAS10089880
    GO:0008283cell proliferation TAS9418904
    GO:0010976positive regulation of neuron projection development IEA--

    Find genes that share ontologies with UBE2V2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2V2 (UB2V2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2V2 gene: 
    NM_003350.2  

    Unigene Cluster for UBE2V2:

    Ubiquitin-conjugating enzyme E2 variant 2
    Hs.491695  [show with all ESTs]
    Unigene Representative Sequence: AK094617
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523111(uc003xqm.3) ENST00000523432 ENST00000521346 ENST00000518360
    ENST00000517630 ENST00000520809 ENST00000520595 ENST00000521628
    miRNA
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    hsa-miR-411* hsa-miR-30c hsa-miR-3607-3p hsa-miR-379* hsa-miR-30d hsa-miR-340 hsa-miR-3923 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidUBE2V2 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat UBE2V2

    Additional mRNA sequence: 

    AF049140.1 AK094617.1 AK313447.1 BC007051.1 BC016332.1 BC016710.1 BC028673.1 BC062418.1 
    BT006744.1 CR407628.1 U62136.2 X98091.1 

    Selected DOTS entries (see all 27):

    DT.92468578  DT.99975199  DT.310202  DT.92468536  DT.91999321  DT.92468530  DT.100827881  DT.100827885 
    DT.92468535  DT.100827883  DT.95284972  DT.100827884  DT.100827877  DT.121485744  DT.121485844  DT.121485861 
    DT.92468588  DT.95284962  DT.95284984  DT.100827873  DT.121485750  DT.95284971  DT.95284988  DT.99980382 

    Selected AceView cDNA sequences (see all 1109):

    CR603543 AV711595 AU127360 AA410994 BE698527 BU941729 BC007051 BU568293 
    AV708041 AI763271 CK821980 CB127259 BM477255 BE348580 BU161929 AI246318 
    AA761592 BE748894 BX092767 F09219 AI673334 AA776914 BP347509 AW024676 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2V2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                                
    SP2:                          -                     
    SP3:              -           -                     


    ECgene alternative splicing isoforms for UBE2V2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2V2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTAAGTT
    UBE2V2 Expression
    About this image

    UBE2V2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2V2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.491695

    UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819
    Tissue specificity: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2V2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2V2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2v21 , 5 ubiquitin-conjugating enzyme E2 variant 21, 5 95.17(n)1
    98.62(a)1
      16 (10.09 cM)5
    706201  NM_023585.41  NP_076074.21 
     155526775 
    chicken
    (Gallus gallus)
    Aves UBE2V21 ubiquitin-conjugating enzyme E2 variant 2 92.59(n)
    97.92(a)
      421109  NM_001031018.1  NP_001026189.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2V26
    ubiquitin-conjugating enzyme E2 variant 2
    92(a)
    1 ↔ 1
    GL343207.1(1481436-1494053)
    African clawed frog
    (Xenopus laevis)
    Amphibia ube2v2-prov2 ubiquitin-conjugating enzyme E2 variant 2 85.11(n)    BC042361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb18b112 Danio rerio cDNA clone MGC63717 IMAGE2602271, complete more 85.27(n)    BC058061.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Uev1A3 ubiquitin conjugating enzyme 67(a)   64D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea uev-13   -- 63(a)   I(14798233-14798904)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MMS21 MMS2 57.53(n)
    50.37(a)
      852793   NP_011428.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UEV1D-41 UEV1D-4 53.72(n)
    50.36(a)
      824422  NM_180353.2  NP_850684.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g02971001 Os09g0297100 53.29(n)
    51.41(a)
      4346652  NM_001069339.1  NP_001062804.1 


    ENSEMBL Gene Tree for UBE2V2 (if available)
    TreeFam Gene Tree for UBE2V2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2V2 gene
    UBE2V12  
    Selected SIMAP similar genes for UBE2V2 using alignment to 6 protein entries:     UB2V2_HUMAN (see all proteins) (see all similar genes):
    UBE2V1    TMEM189    X-linked retinopathy protein    NEK4    NLN    RPS6KA5
    COQ5    EEF1E1    IDNK    KIAA1651    LSM12    SEC14L3
    SNRPF    C14orf105    MLL5    RHBG    SEPSECS    TBCB

    Find genes that share paralogs with UBE2V2           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for UBE2V2 (see all 15)
    PGOHUM00000238682 PGOHUM00000238926 PGOHUM00000239678 PGOHUM00000237184 PGOHUM00000243890


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2V2 (see all 879)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900406421,2
    --48919042(+) CTTACA/GATTGC 1 -- int10--------
    rs1444206171,2
    --48919082(+) GAACAC/TTGATG 1 -- int10--------
    rs1816706101,2
    --48919148(+) TTATCC/TACCAA 1 -- int10--------
    rs1466286061,2
    --48919161(+) TCAAGA/TCGGCT 1 -- int10--------
    rs1860085741,2
    --48919252(+) AACCAC/TATGAT 1 -- int10--------
    rs1888082301,2
    --48919291(+) ACAAAA/GTTCAA 1 -- int10--------
    rs1812265481,2
    --48919385(+) CACAGA/CCAATA 1 -- int10--------
    rs1854908381,2
    --48919510(+) ATCTCA/GGTTCA 1 -- int10--------
    rs1908530051,2
    --48919543(+) TCACGC/TCATTC 1 -- int10--------
    rs1821642851,2
    --48919565(+) CCTCCC/TGAGTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for UBE2V2 (48920960 - 48977268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UBE2V2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831309CNV Loss17160897
    dgv7784n71CNV Gain21882294
    nsv8338CNV Gain+Loss18304495
    dgv2234e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2V2
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2V2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603001    OMIM disorders: --


    Find genes that share disorders with UBE2V2           About GenesLikeMe

    Genetic Association Database (GAD): UBE2V2

    Export disorders for UBE2V2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2V2 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with UBE2V2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular Cloning of a 1alpha,25-dihydroxyvitamin D3 inducible transcript (DDVit 1) in human blood monocytes. (PubMed id 9199207)1, 2, 3 Fritsche J.... Kreutz M. (Biochem. Biophys. Res. Commun. 1997)
    2. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. (PubMed id 9705497)1, 2, 9 Xiao W.... Wei Y.-F. (Nucleic Acids Res. 1998)
    3. Molecular insights into the function of RING Finger (RNF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation. (PubMed id 22589545)1, 2 Campbell S.J.... Glover J.N. (J. Biol. Chem. 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. (PubMed id 14562038)1, 2 Bothos J.... Halazonetis T.D. (Oncogene 2003)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. (PubMed id 11473255)1, 2 Moraes T.F.... Ellison M.J. (Nat. Struct. Biol. 2001)
    8. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. (PubMed id 10089880)1, 2 Hofmann R.M. and Pickart C.M. (Cell 1999)
    9. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PubMed id 9418904)1, 3 Sancho E.... Thomson T.M. (Mol. Cell. Biol. 1998)
    10. Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States. (PubMed id 15952783)1, 9 Spyracopoulos L....Saltibus L.F. (Biochemistry 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7336 HGNC: 12495 AceView: UBE2V2 Ensembl:ENSG00000169139 euGenes: HUgn7336
    ECgene: UBE2V2 H-InvDB: UBE2V2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2V2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2V2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2V2 gene:
    Search GeneIP for patents involving UBE2V2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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