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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2V2 Gene

protein-coding   GIFtS: 64
GCID: GC08P048970

Ubiquitin-Conjugating Enzyme E2 Variant 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2 Variant 21 2     MMS2 Homolog2 3
Enterocyte Differentiation-Associated Factor 12 3     1 Alpha,25-Dihydroxyvitamin D3-Inducible2
Enterocyte Differentiation-Promoting Factor 12 3     DDVIT12
Vitamin D3-Inducible Protein2 3     DDVit-12
EDAF-12 3     EDPF12
EDPF-12 3     UEV-22
MMS22 3     Enterocyte Differentiation Promoting Factor2
UEV22 3     Enterocyte Differentiation-Associated Factor EDAF-12
DDVit 12 3     Methyl Methanesulfonate Sensitive 2, S. Cerevisiae, Homolog Of2

External Ids:    HGNC: 124951   Entrez Gene: 73362   Ensembl: ENSG000001691397   OMIM: 6030015   UniProtKB: Q158193   

Export aliases for UBE2V2 gene to outside databases

Previous GC identifers: GC08P048012 GC08P048925 GC08P048644 GC08P049083 GC08P044383


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2V2 Gene:
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family.
They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that
is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with
ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation
of monocytes and enterocytes. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2V2 Gene: 
UBE2V2 (ubiquitin-conjugating enzyme E2 variant 2) is a protein-coding gene. Diseases associated with UBE2V2 include breast cancer, and neuronitis, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include protein binding and acid-amino acid ligase activity. An important paralog of this gene is TMEM189.

UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819
Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of
non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not
lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role
in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair
pathway and contributes to the survival of cells after DNA damage

Gene Wiki entry for UBE2V2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008183.19  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2V2 gene promoter:
         Nkx3-1   Elk-1   Nkx3-1 v4   Nkx3-1 v1   CUTL1   HNF-1A   c-Ets-1   Nkx3-1 v2   NRF-2   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2V2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2V2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2V2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q11.21   Ensembl cytogenetic band:  8q11.21   HGNC cytogenetic band: 8q11.21

UBE2V2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2V2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P048970:  view genomic region     (about GC identifiers)

Start:
48,920,960 bp from pter      End:
48,977,268 bp from pter
Size:
56,309 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 variant 2  
Size: 145 amino acids; 16363 Da
Subunit: Heterodimer with UBE2N. Binds CHFR
5 PDB 3D structures from and Proteopedia for UBE2V2:
1J74 (3D)        1J7D (3D)        1ZGU (3D)        3VON (3D)        4EPO (3D)    

Explore the universe of human proteins at neXtProt for UBE2V2: NX_Q15819

Explore proteomics data for UBE2V2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15819

  • UBE2V2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2V2 Protein Expression
    REFSEQ proteins: NP_003341.1  
    ENSEMBL proteins: 
     ENSP00000428209   ENSP00000430019   ENSP00000428818   ENSP00000430491   ENSP00000429886  
     ENSP00000429419   ENSP00000430741  
    Reactome Protein details: Q15819
    Human Recombinant Protein Products for UBE2V2: 
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    ProSpec Recombinant Protein for UBE2V2
    Cloud-Clone Corp. Proteins for UBE2V2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16129784
    GO:0005737cytoplasm TAS16129784
    GO:0031372UBC13-MMS2 complex IDA16129784

    UBE2V2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q15819

    ProtoNet protein and cluster: Q15819

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2V2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2V2_HUMAN, Q15819
    Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of
    non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not
    lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role
    in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair
    pathway and contributes to the survival of cells after DNA damage
    Induction: Up-regulated in cultured fresh blood cells upon treatment with vitamin D3

         Genatlas biochemistry entry for UBE2V2:
    ubiquitin conjugating enzyme E2 variant 2,expressed in monocytes and in some cancer lines,putatively involved in
    the control of differentiation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI11473255
    GO:0016881acid-amino acid ligase activity IEA--
         
    UBE2V2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2V2:
     Increased cell death in breast 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2V2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2V2 
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    SwitchGear 3'UTR luciferase reporter plasmidUBE2V2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2V2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Immune response T cell receptor signaling pathway
    Immune response T cell receptor signaling pathway0.88
    4Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Common schema of ubiquitination0.36
    5Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for UBE2V2
        Common schema of ubiquitination
    Immune response T cell receptor signaling pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2V2
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for UBE2V2
        Immune response T cell receptor signaling pathway

    4        Reactome Pathways for UBE2V2
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System



    UBE2V2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2V2

    5/66 Interacting proteins for UBE2V2 (Q158191, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOB4Q9Y3A32, 3MINT-65831 I2D: score=5 
    IGSF21Q96ID52, 3MINT-64269 I2D: score=4 
    LRIF1Q5T3J32, 3MINT-64270 I2D: score=4 
    UBE2NP610881, 3EBI-714329,EBI-1052908 I2D: score=15 
    BCL10O959993I2D: score=4 
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS10089880
    GO:0000729DNA double-strand break processing IMP17349954
    GO:0006282regulation of DNA repair TAS10089880
    GO:0008283cell proliferation TAS9418904
    GO:0010976positive regulation of neuron projection development IEA--

    UBE2V2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2V2 (UB2V2)

    Search CenterWatch for drugs/clinical trials and news about UBE2V2 / UB2V2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2V2 gene: 
    NM_003350.2  

    Unigene Cluster for UBE2V2:

    Ubiquitin-conjugating enzyme E2 variant 2
    Hs.491695  [show with all ESTs]
    Unigene Representative Sequence: AK094617
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000523111(uc003xqm.3) ENST00000523432 ENST00000521346 ENST00000518360
    ENST00000517630 ENST00000520809 ENST00000520595 ENST00000521628
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidUBE2V2 3' UTR sequence
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    Additional mRNA sequence: 

    AF049140.1 AK094617.1 AK313447.1 BC007051.1 BC016332.1 BC016710.1 BC028673.1 BC062418.1 
    BT006744.1 CR407628.1 U62136.2 X98091.1 

    24/27 DOTS entries (see all 27):

    DT.92468578  DT.99975199  DT.310202  DT.92468536  DT.91999321  DT.92468530  DT.100827881  DT.100827885 
    DT.92468535  DT.100827883  DT.95284972  DT.100827884  DT.100827877  DT.121485744  DT.121485844  DT.121485861 
    DT.92468588  DT.95284962  DT.95284984  DT.100827873  DT.121485750  DT.95284971  DT.95284988  DT.99980382 

    24/1109 AceView cDNA sequences (see all 1109):

    N24763 BU567372 BE879647 AA688293 BP347509 AA947734 BF197488 BU677186 
    AI673334 BU679776 BM542421 AW024676 CB143808 CA441431 BM845323 CD677592 
    F09219 AA776914 BX092767 BE748894 AA761592 AI246318 BU161929 BE348580 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2V2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c
    SP1:                                                
    SP2:                          -                     
    SP3:              -           -                     


    ECgene alternative splicing isoforms for UBE2V2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2V2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATTTAAGTT
    UBE2V2 Expression
    About this image


    See UBE2V2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2V2

    SOURCE GeneReport for Unigene cluster: Hs.491695

    UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819
    Tissue specificity: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2V2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2V2 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2v21 , 5 ubiquitin-conjugating enzyme E2 variant 21, 5 95.17(n)1
    98.62(a)1
      16 (10.09 cM)5
    706201  NM_023585.41  NP_076074.21 
     155526775 
    chicken
    (Gallus gallus)
    Aves UBE2V21 ubiquitin-conjugating enzyme E2 variant 2 92.59(n)
    97.92(a)
      421109  NM_001031018.1  NP_001026189.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2V26
    Uncharacterized protein
    92(a)
    1 ↔ 1
    GL343207.1(1481436-1494053)
    African clawed frog
    (Xenopus laevis)
    Amphibia ube2v2-prov2 ubiquitin-conjugating enzyme E2 variant 2 85.11(n)    BC042361.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb18b112 Danio rerio cDNA clone MGC63717 IMAGE2602271, complete more 85.27(n)    BC058061.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Uev1A3 ubiquitin conjugating enzyme 67(a)   64D1   --
    worm
    (Caenorhabditis elegans)
    Secernentea uev-11 , 3 Protein UEV-11 63(a)3
    59.12(n)1
    64.23(a)1
      I(14798233-14798904)3
    1733471  NM_061177.41  NP_493578.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MMS21 Mms2p 57.53(n)
    50.37(a)
      852793   NP_011428.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons MMZ31 ubiquitin-conjugating enzyme E2 variant 1C 53.68(n)
    52.94(a)
      818179  NM_179928.2  NP_850259.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g02971001 hypothetical protein 54.41(n)
    53.68(a)
      4346652  NM_001069339.1  NP_001062804.1 


    ENSEMBL Gene Tree for UBE2V2 (if available)
    TreeFam Gene Tree for UBE2V2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2V2 gene
    TMEM1892  UBE2V12  TMEM189-UBE2V12  
    18/42 SIMAP similar genes for UBE2V2 using alignment to 6 protein entries:     UB2V2_HUMAN (see all proteins) (see all similar genes):
    UBE2V1    TMEM189    X-linked retinopathy protein    NEK4    NLN    RPS6KA5
    COQ5    EEF1E1    IDNK    KIAA1651    LOC100996426    LOC100996577
    LSM12    SEC14L3    SNRPF    C14orf105    MLL5    RHBG

    UBE2V2 for paralogs           About GeneDecksing


    5/15 Pseudogenes.org Pseudogenes for UBE2V2 (see all 15)
    PGOHUM00000238682 PGOHUM00000238926 PGOHUM00000239678 PGOHUM00000237184 PGOHUM00000243890


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/879 SNPs in UBE2V2 are shown (see all 879)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0524324
    ----see VAR_0524322 D H mis40--------
    rs1900406421,2
    --48919042(+) CTTACA/GATTGC 1 -- int10--------
    rs1444206171,2
    --48919082(+) GAACAC/TTGATG 1 -- int10--------
    rs1816706101,2
    --48919148(+) TTATCC/TACCAA 1 -- int10--------
    rs1466286061,2
    --48919161(+) TCAAGA/TCGGCT 1 -- int10--------
    rs1860085741,2
    --48919252(+) AACCAC/TATGAT 1 -- int10--------
    rs1888082301,2
    --48919291(+) ACAAAA/GTTCAA 1 -- int10--------
    rs1812265481,2
    --48919385(+) CACAGA/CCAATA 1 -- int10--------
    rs1854908381,2
    --48919510(+) ATCTCA/GGTTCA 1 -- int10--------
    rs1908530051,2
    --48919543(+) TCACGC/TCATTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for UBE2V2 (48920960 - 48977268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UBE2V2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv831309CNV Loss17160897
    dgv7784n71CNV Gain21882294
    nsv8338CNV Gain+Loss18304495
    dgv2234e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603001    OMIM disorders: --

    2 diseases for UBE2V2:    About MalaCards
    breast cancer    neuronitis


    UBE2V2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBE2V2

    Export disorders for UBE2V2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2V2 gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with UBE2V2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. (PubMed id 9199207)1, 2, 3 Fritsche J....Kreutz M. (1997)
    2. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. (PubMed id 9705497)1, 2, 9 Xiao W.... Wei Y.-F. (1998)
    3. Molecular insights into the function of RING finger (R NF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation . (PubMed id 22589545)1, 2 Campbell S.J....Glover J.N. (2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. (PubMed id 14562038)1, 2 Bothos J.... Halazonetis T.D. (2003)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. (PubMed id 11473255)1, 2 Moraes T.F.... Ellison M.J. (2001)
    8. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. (PubMed id 10089880)1, 2 Hofmann R.M. and Pickart C.M. (1999)
    9. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PubMed id 9418904)1, 3 Sancho E.... Thomson T.M. (1998)
    10. Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States. (PubMed id 15952783)1, 9 Spyracopoulos L....Saltibus L.F. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7336 HGNC: 12495 AceView: UBE2V2 Ensembl:ENSG00000169139 euGenes: HUgn7336
    ECgene: UBE2V2 H-InvDB: UBE2V2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2V2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2V2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2V2 gene:
    Search GeneIP for patents involving UBE2V2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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