UBE2V2 Gene
protein-coding GIFtS: 65
GCID: GC08P048970
|
|
ubiquitin-conjugating enzyme E2 variant 2
| |
Aliases
for UBE2V2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2 Variant 21 2 | | UEV22 3 | | EDPF-11 2 3 | | DDVit 12 3 | | MMS21 2 3 | | MMS2 Homolog2 3 | | DDVit-11 2 | | 1 Alpha,25-Dihydroxyvitamin D3-Inducible2 | | UEV-21 2 | | DDVIT12 | | Enterocyte Differentiation-Associated Factor 12 3 | | EDPF12 | | Enterocyte Differentiation-Promoting Factor 12 3 | | Enterocyte Differentiation Promoting Factor2 | | Vitamin D3-Inducible Protein2 3 | | Enterocyte Differentiation-Associated Factor EDAF-12 | | EDAF-12 3 | | Methyl Methanesulfonate Sensitive 2, S. Cerevisiae, Homolog Of2 |
Export aliases for UBE2V2 gene to outside databasesPrevious GC identifers: GC08P048012 GC08P048925 GC08P048644 GC08P049083 GC08P044383 |
Summaries
for UBE2V2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2V2:
Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. Theyhave sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that iscritical for the catalytic activity of E2s. The protein encoded by this gene also shares homology withubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation ofmonocytes and enterocytes. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis ofnon-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not leadto protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in thecontrol of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway andcontributes to the survival of cells after DNA damage
Gene Wiki entry for UBE2V2
|
Genomic Views
for UBE2V2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008183.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2V2 gene promoter:
Nkx3-1 Elk-1 Nkx3-1 v4 Nkx3-1 v1 CUTL1 HNF-1A c-Ets-1 Nkx3-1 v2 NRF-2 Nkx3-1 v3
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2V2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2V2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q11.21 Ensembl cytogenetic band: 8q11.21 HGNC cytogenetic band: 8q11.21UBE2V2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P048970: view genomic region
(about GC identifiers)
Start:
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48,920,960 bp from pter |
End:
|
48,976,511 bp from pter |
Size:
|
55,552 bases |
Orientation:
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plus strand |
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Proteins
for UBE2V2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 variant 2 Size: 145 amino acids; 16363 Da
Subunit: Heterodimer with UBE2N. Binds CHFR
5 PDB 3D structures from  and Proteopedia  for UBE2V2:1J74 (3D)
1J7D (3D)
1ZGU (3D)
3VON (3D)
4EPO (3D)
Explore the universe of human proteins at neXtProt for UBE2V2: NX_Q15819
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15819
UBE2V2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003341.1
ENSEMBL proteins: ENSP00000428209 ENSP00000430019 ENSP00000428818 ENSP00000430491 ENSP00000429886 ENSP00000429419 ENSP00000430741 ENSP00000326473 ENSP00000430218 Reactome Protein details: Q15819
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
UBE2V2 for ontologies About GeneDecksing
UBE2V2 Antibody Products:
Assay Products for UBE2V2: |
Protein
Domains /
Families
for UBE2V2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2V2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15819ProtoNet protein and cluster: Q15819 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function
for UBE2V2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819Function: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis ofnon-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not leadto protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in thecontrol of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway andcontributes to the survival of cells after DNA damageInduction: Up-regulated in cultured fresh blood cells upon treatment with vitamin D3 Genatlas biochemistry entry for UBE2V2:ubiquitin conjugating enzyme E2 variant 2,expressed in monocytes and in some cancer lines,putatively involved in thecontrol of differentiation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2V2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2V2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBE2V2 (NM_003350) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2V2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2V2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2V2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
UBE2V2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UBE2V2:
|
Pathways & Interactions
for UBE2V2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Immune response T cell receptor signaling pathway | | | 4 | Ubiquitin-Proteasome Dependent Proteolysis | | | 5 | Remodeling of Adherens Junctions | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for UBE2V2
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2V2
1  GeneGo (Thomson Reuters) Pathway for UBE2V2
5 
Reactome Pathways for UBE2V2
UBE2V2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2V2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/88 Interacting proteins for UBE2V2 (Q158191, 2, 3 ENSP000003264734) via UniProtKB, MINT, STRING, and/or I2D (see all 88)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
UBE2V2 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2V2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBE2V2
Search CenterWatch for drugs/clinical trials and news about UBE2V2 / UB2V2
|
Transcripts
for UBE2V2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE2V2 gene: NM_003350.2 Unigene Cluster for UBE2V2: Ubiquitin-conjugating enzyme E2 variant 2 Hs.491695 [show with all ESTs]Unigene Representative Sequence: AK0946179 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000523111(uc003xqm.3) ENST00000523432 ENST00000521346 ENST00000518360
ENST00000517630 ENST00000520809 ENST00000520595 ENST00000324746 ENST00000521628
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2V2 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2V2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBE2V2 (NM_003350) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2V2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2V2 |
Additional cDNA sequence: AF049140.1 AK094617.1 AK313447.1 BC007051.1 BC016332.1 BC016710.1 BC028673.1 BC062418.1 BT006744.1 CR407628.1 U62136.2 X98091.1 24/26 DOTS entries (see all 26): DT.92468578 DT.99975199 DT.92468536 DT.310202 DT.91999321 DT.92468530 DT.100827881 DT.100827885 DT.92468535 DT.100827883 DT.95284972 DT.100827884 DT.100827877 DT.121485744 DT.121485844 DT.121485861 DT.92468588 DT.95284962 DT.95284984 DT.100827873 DT.121485750 DT.95284971 DT.95284988 DT.99980382 24/1109 AceView cDNA sequences (see all 1109): BU568293 AW514211 BG290773 CR603464 AI246318 BU161929 BE348580 NM_003350 BG500055 AA947734 AA410994 BE698527 CR603543 BM833841 AU127360 AV711595 F11561 CK821980 AI763271 BM477255 BC062418 AA805778 BE748894 N20222
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2V2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | |
| SP3: | | | | | - | | | | - | | | | | | | |
ECgene alternative splicing isoforms for UBE2V2
|
Expression
for UBE2V2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2V2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATTTAAGTT
About this image
See UBE2V2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2V2
SOURCE GeneReport for Unigene cluster: Hs.491695
UniProtKB/Swiss-Prot: UB2V2_HUMAN, Q15819Tissue specificity: Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues
SABiosciences Custom PCR Arrays for UBE2V2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2V2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2V2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2V2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2V2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2V2 |
Orthologs
for UBE2V2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2V2 gene from 10/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ube2v21 , 5 |
ubiquitin-conjugating enzyme E2 variant 21, 5 |
95.17(n)1
98.62(a)1 |
|
16 (10.09 cM)5
706201 NM_023585.41 NP_076074.21
155526775 |
chicken
(Gallus gallus) |
Aves |
UBE2V21 |
ubiquitin-conjugating enzyme E2 variant 2 |
92.59(n)
97.92(a) |
|
421109 NM_001031018.1 NP_001026189.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UBE2V26 |
-- |
93(a) |
1 ↔ 1 |
GL343207.1(1481528-1494053) |
African clawed frog
(Xenopus laevis) |
Amphibia |
ube2v2-prov2 |
ubiquitin-conjugating enzyme E2 variant 2 |
85.11(n) |
|
BC042361.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufb18b112 |
Danio rerio cDNA clone MGC63717 IMAGE2602271, complete more |
85.27(n) |
|
BC058061.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Uev1A3 |
ubiquitin conjugating enzyme |
67(a) |
|
64D1 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
uev-11 , 3 |
Protein UEV-11 |
63(a)3
59.12(n)1
64.23(a)1 |
|
I(14798233-14798904)3
1733471 NM_061177.41 NP_493578.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
MMS2(YGL087C)4
MMS21 |
Ubiquitin-conjugating enzyme variant involved in error-free more4
Mms2p1 |
57.53(n)1
50.37(a)1 |
|
7(346904-346406)4
8527931, 4 NP_011428.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
MMZ31 |
ubiquitin-conjugating enzyme E2 variant 1C |
53.68(n)
52.94(a) |
|
818179 NM_179928.2 NP_850259.1 |
rice
(Oryza sativa) |
Liliopsida |
Os09g02971001 |
hypothetical protein |
54.41(n)
53.68(a) |
|
4346652 NM_001069339.1 NP_001062804.1 |
ENSEMBL Gene Tree for UBE2V2 (if available)
TreeFam Gene Tree for UBE2V2 (if available) |
Paralogs
for UBE2V2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE2V2 gene
- TMEM1892 UBE2V12 TMEM189-UBE2V12
18/38 SIMAP similar genes for UBE2V2 using alignment to 7 protein entries: UB2V2_HUMAN (see all proteins)
(see all similar genes):UBE2V1 X-linked retinopathy protein TMEM189 NEK4 NLN RPS6KA5
COQ5 EEF1E1 IDNK KIAA1651 LSM12 SEC14L3
SNRPF C14orf105 MLL5 RHBG SEPSECS ACTR10
UBE2V2 for paralogs About GeneDecksing
5/15 Pseudogenes.org Pseudogenes for UBE2V2 (see all 15)
PGOHUM00000238682 PGOHUM00000238926 PGOHUM00000239678 PGOHUM00000237184 PGOHUM00000243890
|
Genomic Variants
for UBE2V2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBE2V2 (48920960 - 48976511 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for UBE2V2
1 CNV: 3730
2 Indels: 33874 33459 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2V2 |
|
Disorders
/ Diseases
for UBE2V2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2V2 for disorders About GeneDecksing
OMIM gene information: 603001
OMIM disorders: --
4  diseases for UBE2V2: About MalaCardsconjunctivitis breast cancer malaria neuronitis
Export disorders for UBE2V2 gene to outside databases
|
Publications
for UBE2V2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBE2V2 gene, integrated from 9 sources (see all 57):
(articles sorted by number of sources associating them with UBE2V2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. (PubMed id 9199207)1, 2, 3 Fritsche J....Kreutz M. (1997)
- The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. (PubMed id 9705497)1, 2, 9 Xiao W.... Wei Y.-F. (1998)
- Molecular insights into the function of RING finger (R NF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation . (PubMed id 22589545)1, 2 Campbell S.J....Glover J.N. (2012)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. (PubMed id 14562038)1, 2 Bothos J.... Halazonetis T.D. (2003)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. (PubMed id 11473255)1, 2 Moraes T.F.... Ellison M.J. (2001)
- Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. (PubMed id 10089880)1, 2 Hofmann R.M. and Pickart C.M. (1999)
- Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PubMed id 9418904)1, 3 Sancho E.... Thomson T.M. (1998)
- Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States. (PubMed id 15952783)1, 9 Spyracopoulos L....Saltibus L.F. (2005)
|
External Searches for UBE2V2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE2V2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2V2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2V2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for UBE2V2 gene:
Search GeneIP for patents involving UBE2V2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UBE2V2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for UBE2V2 | | OriGene shRNA RFP for UBE2V2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2V2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2V2 | | | OriGene Protein Over-expression Lysate for UBE2V2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBE2V2 | | OriGene 3'-UTR Clone for UBE2V2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2V2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2V2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBE2V2 | | OriGene Custom Protein Services for UBE2V2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2V2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2V2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2V2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2V2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2V2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2V2 |
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| | | | Search Tocris compounds for UBE2V2 |
| |  |  |  |  | | | | | | Recombinant Protein for UBE2V2 |
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 | | | UBE2V2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2V2 |
|  |  |  | | | | ThermoFisher Antibodies for UBE2V2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2V2 |
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