Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBE2V1 Gene

Aliases for UBE2V1 Gene

  • Ubiquitin-Conjugating Enzyme E2 Variant 1 2 3
  • UEV1 3 4 6
  • TRAF6-Regulated IKK Activator 1 Beta Uev1A 3 4
  • CROC-1 3 4
  • UBE2V 3 4
  • CROC1 3 4
  • UEV-1 3 4
  • DNA-Binding Protein 3
  • UEV1A 3
  • CIR1 3

External Ids for UBE2V1 Gene

Previous Symbols for UBE2V1 Gene

  • UBE2V

Summaries for UBE2V1 Gene

Entrez Gene Summary for UBE2V1 Gene

  • Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]

GeneCards Summary for UBE2V1 Gene

UBE2V1 (Ubiquitin-Conjugating Enzyme E2 Variant 1) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is UBE2V2.

UniProtKB/Swiss-Prot for UBE2V1 Gene

  • Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.

Gene Wiki entry for UBE2V1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2V1 Gene

Genomics for UBE2V1 Gene

Genomic Location for UBE2V1 Gene

Start:
50,081,124 bp from pter
End:
50,115,959 bp from pter
Size:
34,836 bases
Orientation:
Minus strand

Genomic View for UBE2V1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2V1 Gene

Regulatory Elements for UBE2V1 Gene

Transcription factor binding sites by QIAGEN in the UBE2V1 gene promoter:

Proteins for UBE2V1 Gene

  • Protein details for UBE2V1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13404-UB2V1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 variant 1
    Protein Accession:
    Q13404
    Secondary Accessions:
    • E1P629
    • Q13403
    • Q13532
    • Q5TGE0
    • Q5TGE3
    • Q96H34
    • Q9GZT0
    • Q9GZW1
    • Q9H4J3
    • Q9H4J4
    • Q9UKL1
    • Q9UM48
    • Q9UM49
    • Q9UM50

    Protein attributes for UBE2V1 Gene

    Size:
    147 amino acids
    Molecular mass:
    16495 Da
    Quaternary structure:
    • Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific Lys-63-linked polyubiquitination activity. Interacts with TRAF6.
    Miscellaneous:
    • In human, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein
    SequenceCaution:
    • Sequence=AAH08944.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC16955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2V1 Gene

    Alternative splice isoforms for UBE2V1 Gene

neXtProt entry for UBE2V1 Gene

Proteomics data for UBE2V1 Gene at MOPED

Post-translational modifications for UBE2V1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys142, Lys148, Lys205, and Lys10

No data available for DME Specific Peptides for UBE2V1 Gene

Domains for UBE2V1 Gene

Gene Families for UBE2V1 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2V1 Gene

UniProtKB/Swiss-Prot:

UB2V1_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • Q13404
genes like me logo Genes that share domains with UBE2V1: view

Function for UBE2V1 Gene

Molecular function for UBE2V1 Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme E2 variant 1,expressed as at least four isoforms,transcriptional activator of FOS promoter,underexpressed in hormone refractory prostate cancer,potentially involved in the control of differentiation
UniProtKB/Swiss-Prot Function: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
UniProtKB/Swiss-Prot Induction: Down-regulated during differentiation of cultured colon adenocarcinoma cells.

Gene Ontology (GO) - Molecular Function for UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 16129784
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity IBA --
GO:0031624 ubiquitin conjugating enzyme binding IEA --
genes like me logo Genes that share ontologies with UBE2V1: view

miRNA for UBE2V1 Gene

miRTarBase miRNAs that target UBE2V1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2V1 Gene

Localization for UBE2V1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2V1 Gene

Nucleus. Note=Excluded from the nucleolus.

Gene Ontology (GO) - Cellular Components for UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 16307917
GO:0005634 nucleus TAS 9305758
GO:0005737 cytoplasm IDA 16129784
GO:0005829 cytosol TAS --
GO:0031371 ubiquitin conjugating enzyme complex IDA 16129784
genes like me logo Genes that share ontologies with UBE2V1: view

Pathways for UBE2V1 Gene

genes like me logo Genes that share pathways with UBE2V1: view

Gene Ontology (GO) - Biological Process for UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS 10089880
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0006282 regulation of DNA repair TAS 10089880
genes like me logo Genes that share ontologies with UBE2V1: view

Transcripts for UBE2V1 Gene

Unigene Clusters for UBE2V1 Gene

Ubiquitin-conjugating enzyme E2 variant 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2V1 Gene

No ASD Table

Relevant External Links for UBE2V1 Gene

GeneLoc Exon Structure for
UBE2V1
ECgene alternative splicing isoforms for
UBE2V1

Expression for UBE2V1 Gene

mRNA expression in normal human tissues for UBE2V1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2V1 Gene

SOURCE GeneReport for Unigene cluster for UBE2V1 Gene Hs.420529

mRNA Expression by UniProt/SwissProt for UBE2V1 Gene

Q13404-UB2V1_HUMAN
Tissue specificity: Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung.
genes like me logo Genes that share expressions with UBE2V1: view

Orthologs for UBE2V1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2V1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 94 (a)
OneToMany
UBE2V1 36
  • 100 (n)
  • 100 (a)
UBE2V1 37
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia UBE2V1 36
  • 99.55 (n)
  • 100 (a)
UBE2V1 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2V1 36
  • 98.41 (n)
  • 100 (a)
UBE2V1 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm5830 37
  • 87 (a)
OneToMany
Gm8325 37
  • 88 (a)
OneToMany
Ube2v1 36
  • 87.07 (n)
  • 93.88 (a)
Ube2v1 16
Ube2v1 37
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100912618 36
  • 87.3 (n)
  • 93.88 (a)
chicken
(Gallus gallus)
Aves UBE2V1 36
  • 91.72 (n)
  • 99.31 (a)
UBE2V1 37
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2V1 37
  • 95 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15969 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6054 36
ube2v1 36
  • 87.76 (n)
  • 95.24 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2v1 36
  • 74.6 (n)
  • 88.44 (a)
ube2v1 37
  • 85 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006937 36
  • 62.83 (n)
  • 70.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Uev1A 36
  • 59.31 (n)
  • 66.9 (a)
Uev1A 37
  • 65 (a)
OneToMany
Uev1A 38
  • 67 (a)
worm
(Caenorhabditis elegans)
Secernentea uev-1 36
  • 60.58 (n)
  • 67.15 (a)
uev-1 37
  • 66 (a)
OneToMany
uev-1 38
  • 66 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MMS2 37
  • 50 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os12g0605400 36
  • 55.48 (n)
  • 51.05 (a)
Species with no ortholog for UBE2V1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2V1 Gene

ENSEMBL:
Gene Tree for UBE2V1 (if available)
TreeFam:
Gene Tree for UBE2V1 (if available)

Paralogs for UBE2V1 Gene

Paralogs for UBE2V1 Gene

Selected SIMAP similar genes for UBE2V1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBE2V1: view

Variants for UBE2V1 Gene

Structural Variations from Database of Genomic Variants (DGV) for UBE2V1 Gene

Variant ID Type Subtype PubMed ID
nsv833999 CNV Loss 17160897
nsv834000 CNV Gain+Loss 17160897

Relevant External Links for UBE2V1 Gene

HapMap Linkage Disequilibrium report
UBE2V1

No data available for Sequence variations from dbSNP and Humsavar for UBE2V1 Gene

Disorders for UBE2V1 Gene

(1) Novoseek inferred disease relationships for UBE2V1 Gene

Disease -log(P) Hits PubMed IDs
tumors 12.1 2
genes like me logo Genes that share disorders with UBE2V1: view

No data available for UniProtKB/Swiss-Prot for UBE2V1 Gene

Publications for UBE2V1 Gene

  1. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. (PMID: 9705497) Xiao W. … Wei Y.-F. (Nucleic Acids Res. 1998) 3 4 23
  2. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. (PMID: 11057907) Deng L. … Chen Z.J. (Cell 2000) 3 4 23
  3. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson T.M. … Guigo R. (Genome Res. 2000) 3 4 23
  4. CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. (PMID: 9305758) Rothofsky M.L. … Lin S.L. (Gene 1997) 2 3 4
  5. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PMID: 9418904) Sancho E. … Thomson T.M. (Mol. Cell. Biol. 1998) 2 3 4

Products for UBE2V1 Gene

Sources for UBE2V1 Gene

Back to Top

Content