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UBE2V1 Gene

protein-coding GIFtS: 62

GC20M048132

ubiquitin-conjugating enzyme E2 variant 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: UBE2V)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CIR1 ^²
CROC-1 ^¹, ², ³
CROC1 ^¹, ², ³
OTTHUMP00000031795 ^²
OTTHUMP00000031796 ^²
OTTHUMP00000039980 ^²
UBE2V ^², ³
UEV-1 ^¹, ², ³
UEV1 ^², ³, ⁵
UEV1A ^¹, ²

Descriptions
DNA-binding protein ^²
TRAF6-regulated IKK activator 1 beta Uev1A ^³
ubiquitin-conjugating enzyme E2 variant 1 ^²

External Ids
HGNC: 12494¹
Entrez Gene: 7335²
UniProtKB: Q13404³
Ensembl: ENSG00000124208⁷

Search outside databases for aliases for UBE2V1 gene

Previous GC identifers: GC20M048426 GC20M049336 GC20M049383

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2V1:

Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2

protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the

conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded

by this gene is located in the nucleus and can cause transcriptional activation of the human FOS

proto-oncogene. It is thought to be involved in the control of differentiation by altering cell

cycle behavior. Multiple alternatively spliced transcripts encoding different isoforms have been

described for this gene. A pseudogene has been identified which is also located on chromosome 20.

Co-transcription of this gene and the neighboring upstream gene generates a rare transcript

(Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each

individual gene product. [provided by RefSeq]

UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404

Function: Has no ubiquitin ligase activity on its own. The UBE2V1/UBE2N heterodimer catalyzes the

synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of

poly-ubiquitination activates IKK and does not seem to involve protein degradation by the

proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.

Mediates transcriptional activation of target genes. Plays a role in the control of progress

through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and

contributes to the survival of cells after DNA damage

Gene Wiki entry for UBE2V1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2V1 gene

Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.2

UBE2V1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M048132: (about GC identifiers)

Start:	48,131,068 bp from pter
End:	48,203,678 bp from pter
Size:	72,611 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 variant 1

Size: 221 amino acids; 25797 Da

Subunit: Heterodimer with UBE2N. Interacts with TRAF6

Subcellular location: Nucleus. Note=Excluded from the nucleolus

Miscellaneous: In humans, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce

independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein

PDB structures from and Proteopedia :

2A4D (3D)

2C2V (3D)

2HLW (3D)

Secondary accessions: Q13403 Q13532 Q96H34 Q9GZT0 Q9GZW1 Q9H4J3 Q9H4J4 Q9UKL1 Q9UM48 Q9UM49 Q9UM50

Alternative splicing: 5 isoforms: Q13404-1 Q13404-2 Q13404-4 Q13404-6 Q13404-7 (Additional isoforms seem to exist)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_001027459.1 NP_068823.2 NP_071887.1 NP_954595.1

ENSEMBL proteins:

ENSP00000360719 ENSP00000360713 ENSP00000360720 ENSP00000379371 ENSP00000360721 ENSP00000360715

ENSP00000346343 ENSP00000360739 ENSP00000360742 ENSP00000340305 ENSP00000344166

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (UEV1A, UBE2V2 +UBE2V1, UBE2V1, UEV1B)
	Human Recombinant Proteins from Abnova (UBE2V1)

OriGene Purified Recombinant Human Protein: UBE2V1

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	9305758
GO:0005737	cytoplasm	IDA	16129784
GO:0031371	ubiquitin conjugating enzyme complex	IDA	16129784

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Antibodies for UBE2V1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE2V1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UEV1A, UBE2V2 +UBE2V1, UBE2V1, UEV1B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2V1)
	Novus Biologicals Antibodies for UBE2V1

Assays for UBE2V1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13404

ProtoNet protein and cluster: Q13404

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2V1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_199144

Applied Biosystems Silencer® siRNAs for UBE2V1

Sigma-Aldrich siRNA and siRNA Panels for UBE2V1

Sigma-Aldrich shRNA Panels and shRNA for UBE2V1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2V1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001032288
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001032288
untagged cDNA clones in CMV expression vector (see all 4): NM_001032288

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021988

UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404

Function: Has no ubiquitin ligase activity on its own. The UBE2V1/UBE2N heterodimer catalyzes the

synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of

poly-ubiquitination activates IKK and does not seem to involve protein degradation by the

proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2.

Mediates transcriptional activation of target genes. Plays a role in the control of progress

through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and

contributes to the survival of cells after DNA damage

Induction: Down-regulated during differentiation of cultured colon adenocarcinoma cells

Genatlas biochemistry entry for UBE2V1:

ubiquitin conjugating enzyme E2 variant 1,expressed as at least four isoforms,transcriptional

activator of FOS promoter,underexpressed in hormone refractory prostate cancer,potentially

involved in the control of differentiation

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	16129784
GO:0016563	transcription activator activity	TAS	9305758
GO:0019787	small conjugating protein ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2V1 (Your Favorite Gene powered by Ingenuity)

NF-&kappa
Protein Ubiquitination Pathway
Hypoxia Signaling in the Cardiovascular System

GeneDecks UBE2V1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2V1

5/23 Interacting proteins for UBE2V1 (Q13404² ENSP00000344166³) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2N	P61088², ENSP00000316176³	MINT-50197 STRING (score=.999)
TRAF6	ENSP00000337853³	STRING (score=.993)
STUB1	ENSP00000219548³	STRING (score=.991)
UBC	ENSP00000344818³	STRING (score=.983)
MAP3K7IP1	ENSP00000216160³	STRING (score=.971)

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	TAS	10089880
GO:0006282	regulation of DNA repair	TAS	10089880
GO:0006355	regulation of transcription, DNA-dependent	TAS	9305758
GO:0019941	modification-dependent protein catabolic process	IEA	--
GO:0030154	cell differentiation	NAS	9418904

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2V1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2V1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_199144

Sigma-Aldrich siRNA and siRNA Panels for UBE2V1

Sigma-Aldrich shRNA Panels and shRNA for UBE2V1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001032288 NM_021988 NM_022442 NM_199144

REFSEQ mRNAs for UBE2V1 gene (4 alternative transcripts):

NM_001032288.1 NM_021988.4 NM_022442.4 NM_199144.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001032288 NM_021988 NM_022442 NM_199144

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_001032288
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_001032288
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_001032288

Additional cDNA sequence:

AB044550.1 AF049671.1 AF155120.1 AK023028.1 AK304595.1 AK314754.1 AY008273.1 BC000468.2

BC005215.1 BC008944.2 BC018893.2 BC142966.1 BC144612.1 BT007382.1 BX647511.1 BX648147.1

CR590901.1 CR591292.1 CR596196.1 CR596657.1 CR597636.1 CR600012.1 CR601155.1 CR604443.1

CR607429.1 CR609580.1 CR610565.1 CR612804.1 CR614759.1 CR615402.1 CR615526.1 CR617021.1

CR617407.1 CR620542.1 CR622665.1 CR622818.1 CR624783.1 U39360.1 U39361.1 U97280.1

U97281.1

24/67 DOTS entries (see all 67 ):

DT.87017867 DT.100881989 DT.100881988 DT.86999436 DT.100882004 DT.95190771 DT.91927742 DT.101965698

DT.95279545 DT.97799662 DT.320480 DT.100758874 DT.95108243 DT.100672690 DT.100881995 DT.100881998

DT.120838136 DT.100881974 DT.75156062 DT.100881992 DT.120837985 DT.40305392 DT.97859427 DT.92467447

24/1050 AceView cDNA sequences (see all 1050 ):

CD672005 CB164261 BG944626 BM994499 BM684455 BX647511 BM974797 CR591292

CR601155 BU860198 BQ004312 BC008944 BG034562 AI084855 BM561707 BQ439854

AA778376 BU507729 U97281 CB152169 BM692858 AA723946 BI091930 BE219066

highest scoring ESTs for UBE2V1:

BI251950 BC005215 BF027716 BQ439854 BQ648631 BU540046 CA453411 U39361 AL036205 AV654677

Unigene Cluster for UBE2V1:

Ubiquitin-conjugating enzyme E2 variant 1

Hs.420529 [show with all ESTs]

Unigene Representative Sequence: NM_199203

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2V1 (see all 16 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	^	9	^	10	^	11	^	12	^	13a	·	13b	·	13c	^	14	^	15a	·	15b	^	16	^	17	^	18	^
SP1:							-				-						-
SP2:							-				-
SP3:
SP4:											-
SP5:							-				-		-		-		-

ExUns:	19a	·	19b	·	19c	^	20a	·	20b	·	20c
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for UBE2V1

11 Ensembl transcripts including schematic representations:

ENST00000371656 ENST00000371650 ENST00000371657 ENST00000396059 ENST00000371658 ENST00000371652

ENST00000354374 ENST00000371674 ENST00000371677 ENST00000340309 ENST00000341698

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2V1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2V1

¹ / ² / ³

5 probe-sets matching UBE2V1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
43832_at²^{, 3}	U95-B	2	1.00	0.50	1.00	1.00	N20198	0.80	0.71	0.76	1
201002_s_at²^{, 3}	U133-A	2	1.00	0.50	--	--	U39361	0.80	0.83	0.82	1
201001_s_at²^{, 3}	U133-A	5	1.00	0.33	--	--	BG164064	0.40	0.67	0.55	1
201002_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
201001_s_at²	U133Plus2	5	1.00	0.33	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.420529
Expression variation in blood from EXPOLDB for UBE2V1
UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404
Tissue specificity: Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea,
adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain,
liver, kidney, stomach and lung

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2V1 gene from 5/12 species (see all 12 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2V1¹	--	ubiquitin-conjugating enzyme E2 variant 1	98.41(n) 100(a)	477262 XM_534454.2 XP_534454.2
chimpanzee (Pan troglodytes)	UBE2V1¹	--	ubiquitin-conjugating enzyme E2 variant 1	99.09(n) 98.64(a)	745497 XM_001166716.1 XP_001166716.1
cow (Bos taurus)	UBE2V1¹	--	ubiquitin-conjugating enzyme E2 variant 1	99.55(n) 100(a)	617771 NM_001035497.1 NP_001030574.1
mouse (Mus musculus)	Ube2v1^{1, 5}	2 (49.60 cM)⁵	ubiquitin-conjugating enzyme E2 variant 1^{1, 5}	87.07(n)¹ 93.88(a)¹	66589¹ NM_023230.2¹ NP_075719.1¹ AF303829⁵ AI256840⁵ (see all 22)
zebrafish (Danio rerio)	zgc:123326¹	--	zgc:123326	74.6(n) 88.44(a)	641324 NM_001037402.1 NP_001032479.1

About this table Species with no ortholog for UBE2V1

ENSEMBL Gene Tree for UBE2V1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for UBE2V1 gene

UBE2V2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602995

1 Novoseek disease relationship for UBE2V1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	14.84	3	10329586 (1), 9705497 (1)

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1 PharmGKB disease relationship for UBE2V1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/26 PubMed articles for UBE2V1 gene (see all 26 ):

Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PubMed id 9418904)^{2, 3, 4} Sancho E.... Thomson T.M. (1998)
CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. (PubMed id 9305758)^{2, 3, 4} Rothofsky M.L. and Lin S.L. (1997)
The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. (PubMed id 9705497)^{1, 3, 4} Xiao W.... Wei Y.-F. (1998)
Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PubMed id 11076860)^{1, 3, 4} Thomson T.M.... Guigo R. (2000)
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. (PubMed id 11057907)^{1, 3, 4} Deng L.... Chen Z.J. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Role of UEV-1A, a homologue of the tumor suppressor protein TSG101, in protection from DNA damage. (PubMed id 9580084)^{3, 4} Thomson T.M.... Arino J. (1998)
Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme. (PubMed id 17709375)^{1, 3} Petroski M.D....Huang J. (2007)
Structure and interactions of the ubiquitin-conjugating enzyme variant human Uev1a: implications for enzymatic synthesis of polyubiquitin chains. (PubMed id 16893187)³ Hau D.D....Spyracopoulos L. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7335	HGNC: 12494	AceView: Kua-UEV	Ensembl:ENSG00000124208	euGenes: HUgn7335
ECgene: UBE2V1	H-InvDB: UBE2V1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for UBE2V1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE2V1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE2V1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2V1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2V1		Antibodies for UBE2V1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE2V1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBE2V1)
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	Recombinant Proteins (UEV1A, UBE2V2 +UBE2V1, UBE2V1, UEV1B)
	Antibodies (UEV1A, UBE2V2 +UBE2V1, UBE2V1, UEV1B)

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Antibodies for UBE2V1

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UBE2V1 Gene at Home site.
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UBE2V1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for UBE2V1

Summaries
for UBE2V1

Genomic Location
for UBE2V1

Proteins
for UBE2V1

Protein Domains/
Families
for UBE2V1

Gene Function
for UBE2V1

Pathways & Interactions
for UBE2V1

Drugs & Compounds
for UBE2V1

Transcripts
for UBE2V1

Expression
for UBE2V1

Orthologs
for UBE2V1

Paralogs
for UBE2V1

SNPs/Variants
for UBE2V1

Disorders & Mutations
for UBE2V1

Medical News
for UBE2V1

Publications
for UBE2V1

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Genome Databases showing UBE2V1

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for UBE2V1

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for UBE2V1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2V1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor UBE2V1

Summariesfor UBE2V1

Genomic Locationfor UBE2V1

Proteinsfor UBE2V1

Protein Domains/Familiesfor UBE2V1

Gene Functionfor UBE2V1

Pathways & Interactionsfor UBE2V1

Drugs & Compoundsfor UBE2V1

Transcriptsfor UBE2V1

Expression for UBE2V1

Orthologsfor UBE2V1

Paralogsfor UBE2V1

SNPs/Variantsfor UBE2V1

Disorders & Mutationsfor UBE2V1

Medical Newsfor UBE2V1

Publicationsfor UBE2V1

Search for UBE2V1

Genome Databases showing UBE2V1

Other Databases showing UBE2V1

Specialized Databases showing UBE2V1

Licensable Technologiesfor UBE2V1

Servicesfor UBE2V1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2V1

Summaries
for UBE2V1

Genomic Location
for UBE2V1

Proteins
for UBE2V1

Protein Domains/
Families
for UBE2V1

Gene Function
for UBE2V1

Pathways & Interactions
for UBE2V1

Drugs & Compounds
for UBE2V1

Transcripts
for UBE2V1

Expression
for UBE2V1

Orthologs
for UBE2V1

Paralogs
for UBE2V1

SNPs/Variants
for UBE2V1

Disorders & Mutations
for UBE2V1

Medical News
for UBE2V1

Publications
for UBE2V1

Licensable Technologies
for UBE2V1

Services
for UBE2V1