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UBE2V1 Gene

protein-coding   GIFtS: 58
GCID: GC20M048698

Ubiquitin-Conjugating Enzyme E2 Variant 1


(Previous symbol: UBE2V)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin-Conjugating Enzyme E2 Variant 11 2     UEV-12 3
UBE2V1 2 3     TRAF6-Regulated IKK Activator 1 Beta Uev1A2 3
UEV12 3 5     CIR12
CROC-12 3     UEV1A2
CROC12 3     DNA-Binding Protein2

External Ids:    HGNC: 124941   Entrez Gene: 73352   Ensembl: ENSG000002446877   OMIM: 6029955   UniProtKB: Q134043   
ORGUL members:         

Export aliases for UBE2V1 gene to outside databases

Previous GC identifers: GC20M048426 GC20M049336 GC20M049383 GC20M048132 GC20M045447


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2V1 Gene:
Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family.
They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that
is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can
cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of
differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple
isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified.
Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which
encodes a fusion protein comprised of sequence sharing identity with each individual gene product. (provided by
RefSeq, Apr 2012)

GeneCards Summary for UBE2V1 Gene:
UBE2V1 (ubiquitin-conjugating enzyme E2 variant 1) is a protein-coding gene. GO annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is UBE2V2.

UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404
Function: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of
non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates
IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of
NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a
role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA
repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific
restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked
polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression
of NF-kappa-B and MAPK-responsive inflammatory genes

Gene Wiki entry for UBE2V1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2V1 gene promoter:
         NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2V1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.2

UBE2V1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2V1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048698:  view genomic region     (about GC identifiers)

Start:
48,697,661 bp from pter      End:
48,732,496 bp from pter
Size:
34,836 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 variant 1  
Size: 147 amino acids; 16495 Da
Subunit: Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box
domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6
Miscellaneous: In human, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and
can also be fused to form a TMEM189-UBE2V1 hybrid protein
Sequence caution: Sequence=AAH08944.2; Type=Erroneous initiation; Sequence=CAC16955.2; Type=Erroneous initiation;
Note=Translation N-terminally shortened;
3 PDB 3D structures from and Proteopedia for UBE2V1:
2A4D (3D)        2C2V (3D)        2HLW (3D)    
Secondary accessions: E1P629 Q13403 Q13532 Q5TGE0 Q5TGE3 Q96H34 Q9GZT0 Q9GZW1 Q9H4J3 Q9H4J4
Q9UKL1 Q9UM48 Q9UM49 Q9UM50
Alternative splicing: 6 isoforms:  Q13404-4   Q13404-1   Q13404-2   Q13404-6   Q13404-7   Q13404-8   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2V1: NX_Q13404

Explore proteomics data for UBE2V1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys142, Lys148, Lys205
  • Modification sites at PhosphoSitePlus

  • See UBE2V1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (17 alternative transcripts): 
    NP_001027459.1  NP_001244322.1  NP_001244323.1  NP_001244324.1  NP_001244325.1  NP_001244326.1  NP_001244327.1  NP_001244328.1  
    NP_001269504.1  NP_001269505.1  NP_001269506.1  NP_001269507.1  NP_001269508.1  NP_001269509.1  NP_068823.2  NP_071887.1  
    NP_954595.1  

    ENSEMBL proteins: 
     ENSP00000360720   ENSP00000360739   ENSP00000340305   ENSP00000407770   ENSP00000360742  
     ENSP00000421351   ENSP00000395264  
    Reactome Protein details: Q13404

    UBE2V1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q13404

    ProtoNet protein and cluster: Q13404

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2V1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2V1_HUMAN, Q13404
    Function: Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of
    non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates
    IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of
    NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a
    role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA
    repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific
    restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked
    polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression
    of NF-kappa-B and MAPK-responsive inflammatory genes
    Induction: Down-regulated during differentiation of cultured colon adenocarcinoma cells

         Genatlas biochemistry entry for UBE2V1:
    ubiquitin conjugating enzyme E2 variant 1,expressed as at least four isoforms,transcriptional activator of FOS
    promoter,underexpressed in hormone refractory prostate cancer,potentially involved in the control of
    differentiation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16129784
    GO:0016881acid-amino acid ligase activity IEA--
         
    Find genes that share ontologies with UBE2V1           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UBE2V1

    miRNA
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    miRTarBase miRNAs that target UBE2V1:
    hsa-mir-16-5p (MIRT001400)

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    Selected qRT-PCR Assays for microRNAs that regulate UBE2V1 (see all 33):
    hsa-miR-576-3p hsa-miR-140-5p hsa-miR-607 hsa-miR-429 hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-219-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UB2V1_HUMAN, Q13404: Nucleus. Note=Excluded from the nucleolus

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA16307917
    GO:0005634nucleus TAS9305758
    GO:0005737cytoplasm IDA16129784
    GO:0005829cytosol TAS--
    GO:0031371ubiquitin conjugating enzyme complex IDA16129784

    Find genes that share ontologies with UBE2V1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2V1 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Interleukin-1 signaling
    Interleukin-1 signaling0.45
    IL1-mediated signaling events0.45
    2Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 9 (TLR9) Cascade0.93
    Toll Like Receptor 3 (TLR3) Cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling0.00
    MyD88 dependent cascade initiated on endosome0.69
    3Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    4TCR signaling (REACTOME)
    Downstream TCR signaling0.73
    TCR signaling0.73
    5Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD1/2 Signaling Pathway0.68


    Find genes that share SuperPaths with UBE2V1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2V1
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions
    Toll-Like Receptors Pathway

    2 GeneGo (Thomson Reuters) Pathways for UBE2V1
        Proteolysis Putative ubiquitin pathway
    Immune response IL-1 signaling pathway

    1 BioSystems Pathway for UBE2V1
        IL1-mediated signaling events


    Selected Reactome Pathways for UBE2V1 (see all 9)
        IRAK1 recruits IKK complex
    IKK complex recruitment mediated by RIP1
    FCERI mediated NF-kB activation
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
    Interleukin-1 signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBE2V1
    Interactions:

        GeneGlobe Interaction Network for UBE2V1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2V1 (Q134041, 2, 3 ENSP000003403054) via UniProtKB, MINT, STRING, and/or I2D (see all 117)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610881, 2, 3, ENSP000003161764EBI-1050671,EBI-1052908 MINT-50197 I2D: score=5 STRING: ENSP00000316176
    ZNRF1Q8ND251, 3, ENSP000003350914EBI-1050671,EBI-2129250 I2D: score=2 STRING: ENSP00000335091
    ENSG00000224994Q9HCM93, ENSP000004119494I2D: score=2 STRING: ENSP00000411949
    RNF5Q999423, ENSP000003642354I2D: score=2 STRING: ENSP00000364235
    ENSG00000183574Q999423I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination TAS10089880
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002755MyD88-dependent toll-like receptor signaling pathway TAS--
    GO:0006282regulation of DNA repair TAS10089880
    GO:0006355regulation of transcription, DNA-templated TAS9305758

    Find genes that share ontologies with UBE2V1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2V1 gene (17 alternative transcripts): 
    NM_001032288.2  NM_001257393.1  NM_001257394.1  NM_001257395.1  NM_001257396.1  NM_001257397.1  NM_001257398.1  NM_001257399.1  
    NM_001282575.2  NM_001282576.1  NM_001282577.2  NM_001282578.2  NM_001282579.1  NM_001282580.1  NM_021988.5  NM_022442.5  
    NM_199144.2  

    Unigene Cluster for UBE2V1:

    Ubiquitin-conjugating enzyme E2 variant 1
    Hs.420529  [show with all ESTs]
    Unigene Representative Sequence: BI089767
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000371657 ENST00000396059 ENST00000371674(uc002xvb.3 uc002xva.3)
    ENST00000340309(uc002xve.3) ENST00000415862 ENST00000371677(uc002xvd.3)
    ENST00000483534 ENST00000492371 ENST00000486653 ENST00000490555 ENST00000493090
    ENST00000467839 ENST00000472923 ENST00000432266 ENST00000470565 ENST00000490289
    ENST00000461960 ENST00000462217
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    Additional mRNA sequence: AF049671.1 

    13 DOTS entries:

    DT.86999436  DT.101965698  DT.100882004  DT.95279545  DT.91927742  DT.97860931  DT.95108243  DT.100881989 
    DT.100680012  DT.100837172  DT.100882003  DT.75156062  DT.87017867 

    Selected AceView cDNA sequences (see all 1050):

    AI989384 AI342795 CK430145 BG819344 BQ685274 BQ221327 AY008273 BG940023 
    CR610565 CR617021 AA632107 AI362120 AI077910 BM799727 BE295324 BQ441690 
    CA393362 CA414658 AA948616 CA848223 BI909653 BQ652458 CN482774 BU165080 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2V1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGGTTTT
    UBE2V1 Expression
    About this image

    UBE2V1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2V1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.420529

    UniProtKB/Swiss-Prot: UB2V1_HUMAN, Q13404
    Tissue specificity: Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone
    marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2V1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2V1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2v11 , 5 ubiquitin-conjugating enzyme E2 variant 11, 5 87.07(n)1
    93.88(a)1
      2 (87.44 cM)5
    665891  NM_023230.21  NP_075719.11 
     1676076385 
    chicken
    (Gallus gallus)
    Aves UBE2V11 ubiquitin-conjugating enzyme E2 variant 1 91.72(n)
    99.31(a)
      100538349  NM_001205097.1  NP_001192026.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2V16
    ubiquitin-conjugating enzyme E2 variant 1
    95(a)
    1 ↔ 1
    4(147633496-147637769)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159692 Xenopus laevis, Similar to ubiquitin-conjugating enzyme more 83.82(n)    BC045066.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2v11 ubiquitin-conjugating enzyme E2 variant 1 74.6(n)
    88.44(a)
      641324  NM_001037402.1  NP_001032479.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Uev1A1 , 3 ubiquitin conjugating enzyme3
    Uev1A1
    67(a)3
    59.31(n)1
    66.9(a)1
      64D13
    386131  NM_139702.31  NP_647959.11 
    worm
    (Caenorhabditis elegans)
    Secernentea uev-11 , 3 uev-11 66(a)3
    60.58(n)1
    67.15(a)1
      I(14798233-14798904)3
    1733471  NM_061177.51  NP_493578.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MMS26
    Ubiquitin-conjugating enzyme variant involved in e...
    50(a)
    1 → many
    VII(346406-346904) YGL087C
    rice
    (Oryza sativa)
    Liliopsida Os12g06054001 Os12g0605400 55.48(n)
    51.05(a)
      4352739  NM_001073756.1  NP_001067224.1 


    ENSEMBL Gene Tree for UBE2V1 (if available)
    TreeFam Gene Tree for UBE2V1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2V1 gene
    UBE2V22  
    2 SIMAP similar genes for UBE2V1 using alignment to 2 protein entries:     UB2V1_HUMAN (see all proteins):
    TMEM189    UBE2V2

    Find genes that share paralogs with UBE2V1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for UBE2V1 (see all 12)
    PGOHUM00000234971 PGOHUM00000244081 PGOHUM00000244417 PGOHUM00000247427 PGOHUM00000240968


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2V1 (see all 26)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs114792591,2
    C--45453194(+) AAAAA-/A/GGACAA 15 -- int11NA 2
    rs1130432271,2
    C--48676501(+) ATCTCA/-AAAAA 15 -- int11Minor allele frequency- -:0.00CSA 2
    rs2000138841,2
    --48681751(+) ATAAA-/ATAT  
            
    ATATA
    15 -- int10--------
    rs30677031,2
    C--48681840(+) tatta-/TATAT 
            
    tataa
    15 -- int10--------
    rs2016041911,2
    C--48681924(+) ATATA-/ATATATA 15 -- int10--------
    rs114816181,2
    C--48689311(+) AAAAA-/A/A   
       A
    /AAA
    TTTTA
    26 -- int1 cds11NA 2
    rs58417911,2
    C--48694426(+) GTAATC/-CGAGC 15 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs2009445891,2
    C--48694592(+) AACAA-/CAAAAA 15 -- int10--------
    rs353384091,2
    C,F--48697883(+) AAAAA-/ACCTTT 15 -- ut31 nc-transcript-variant2Minor allele frequency- A:0.50NA CSA 4
    rs711905361,2
    C--48710665(+) ATATA-/TTATA 
            
    ATTAT
    15 -- int11Minor allele frequency- TTATA:0.00NA 2

    HapMap Linkage Disequilibrium report for UBE2V1 (48697661 - 48732496 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for UBE2V1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833999CNV Loss17160897
    nsv834000CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2V1
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2V1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602995    OMIM disorders: --


    Find genes that share disorders with UBE2V1           About GenesLikeMe

    1 Novoseek inferred disease relationship for UBE2V1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 12.1 3 10329586 (1), 9705497 (1)


    Export disorders for UBE2V1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2V1 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with UBE2V1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29- M6 intestinal mucosecretory cells. (PubMed id 9418904)1, 2, 3 Sancho E.... Thomson T.M. (Mol. Cell. Biol. 1998)
    2. CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. (PubMed id 9305758)1, 2, 3 Rothofsky M.L. and Lin S.L. (Gene 1997)
    3. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family. (PubMed id 9705497)1, 2, 9 Xiao W.... Wei Y.-F. (Nucleic Acids Res. 1998)
    4. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PubMed id 11076860)1, 2, 9 Thomson T.M.... Guigo R. (Genome Res. 2000)
    5. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. (PubMed id 11057907)1, 2, 9 Deng L.... Chen Z.J. (Cell 2000)
    6. TRIM5 is an innate immune sensor for the retrovirus capsid lattice. (PubMed id 21512573)1, 2 Pertel T.... Luban J. (Nature 2011)
    7. Chaperoned ubiquitylation -- crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex. (PubMed id 16307917)1, 2 Zhang M....Pearl L.H. (Mol. Cell 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7335 HGNC: 12494 AceView: Kua-UEV Ensembl:ENSG00000244687 euGenes: HUgn7335
    ECgene: UBE2V1 H-InvDB: UBE2V1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2V1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2V1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2V1 gene:
    Search GeneIP for patents involving UBE2V1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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