UBE2U Gene
protein-coding GIFtS: 51
GCID: GC01P064669
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ubiquitin-conjugating enzyme E2U (putative)
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Aliases
for UBE2U gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2U (Putative)1 2 | | RP4-636O23.12 | | Ubiquitin Carrier Protein U2 3 | | Ubiquitin-Conjugating Enzyme E2 U2 | | Ubiquitin-Protein Ligase U2 3 | | EC 6.3.2.193 | | MGC351301 | | |
Export aliases for UBE2U gene to outside databasesPrevious GC identifers: GC01P064382 GC01P062778 |
Summaries
for UBE2U gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: UBE2U_HUMAN, Q5VVX9Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
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Genomic Views
for UBE2U gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2U gene promoter:
ER-alpha Sox5 RREB-1 Pax-2 Nkx2-5 Ik-3 Evi-1 AREB6 FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2U
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2U |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p31.3 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.3UBE2U Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P064669: view genomic region
(about GC identifiers)
Start:
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64,669,310 bp from pter |
End:
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64,733,051 bp from pter |
Size:
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63,742 bases |
Orientation:
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plus strand |
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Proteins
for UBE2U gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBE2U_HUMAN, Q5VVX9 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 U Size: 321 amino acids; 37741 Da
1 PDB 3D structure from  and Proteopedia  for UBE2U:1YRV (3D)
Secondary accessions: Q8N1D4Alternative splicing: 2 isoforms: Q5VVX9-1 Q5VVX9-2 Explore the universe of human proteins at neXtProt for UBE2U: NX_Q5VVX9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5VVX9
UBE2U Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689702.1
ENSEMBL proteins: ENSP00000360117 ENSP00000360116 Reactome Protein details: Q5VVX9
Human Recombinant Protein Products:
UBE2U Antibody Products:
Assay Products for UBE2U: |
Protein
Domains /
Families
for UBE2U gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2U for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5VVX9ProtoNet protein and cluster: Q5VVX9 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBE2U_HUMAN, Q5VVX9Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function
for UBE2U gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBE2U_HUMAN, Q5VVX9Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.191
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2U
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2U |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
UBE2U for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for UBE2U:
|
Pathways & Interactions
for UBE2U gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for UBE2U
1 
Kegg Pathway (Kegg details for UBE2U):
UniProtKB/Swiss-Prot: UBE2U_HUMAN, Q5VVX9Pathway: Protein modification; protein ubiquitination
UBE2U for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2U
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/81 Interacting proteins for UBE2U (Q5VVX93 ENSP000003601164) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
About this table
|
Drugs & Compounds
for UBE2U gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBE2U
4 HMDB Compounds for UBE2U About this table
Search CenterWatch for drugs/clinical trials and news about UBE2U
|
Transcripts
for UBE2U gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE2U gene: NM_152489.1 Unigene Cluster for UBE2U: Ubiquitin-conjugating enzyme E2U (putative) Hs.388746 [show with all ESTs]Unigene Representative Sequence: BC0298953 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371077 ENST00000371076(uc001dbn.1) ENST00000464349
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2U (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2U
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBE2U (NM_152489) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2U | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2U |
Additional cDNA sequence: BC029895.1 3 DOTS entries: DT.100015008 DT.70100712 DT.70103714 21 AceView cDNA sequences: AI198955 BQ022574 NM_152489 BC029895 AI538316 BI825812 AI478778 AI208348 BU193579 BG773201 BX116499 AI377288 AA626174 AW136185 AI655911 BG773116 BI462751 AI765312 R20805 BU561173 R20919
GeneLoc Exon Structure
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Expression
for UBE2U gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2U expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCTTCAGAG
About this image
See UBE2U Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2U
SOURCE GeneReport for Unigene cluster: Hs.388746
SABiosciences Custom PCR Arrays for UBE2U
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2U
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UBE2U | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2U | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2U | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2U |
Orthologs
for UBE2U gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for UBE2U gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ube2u1 , 5 |
ubiquitin-conjugating enzyme E2U (putative)1, 5 |
73.3(n)1
57.08(a)1 |
|
4 (45.72 cM)5
3815341 NM_001033773.41 NP_001028945.21
1004788495 |
worm
(Caenorhabditis elegans) |
Secernentea |
ubc-246 |
UBiquitin Conjugating enzyme family member (ubc-24... |
29(a) |
1 ↔ 1 |
II(8405552-8406876) |
ENSEMBL Gene Tree for UBE2U (if available)
TreeFam Gene Tree for UBE2U (if available) |
Paralogs
for UBE2U gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE2U gene
- UBE2C2
14 SIMAP similar genes for UBE2U using alignment to 1 protein entry: UBE2U_HUMAN:UBE2C HR6A UBE2A UBE2B UBE2L6 UBE2G1
UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBE2DNL
UBE2G2 UBE2I
UBE2U for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UBE2U
PGOHUM00000246298
|
Genomic Variants
for UBE2U gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBE2U (64669310 - 64733051 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBE2U
1 CNV: 3292 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2U |
|
Disorders
/ Diseases
for UBE2U gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2U for disorders About GeneDecksing
1  disease for UBE2U: About MalaCardscrohn's disease
Export disorders for UBE2U gene to outside databases
|
Publications
for UBE2U gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBE2U gene integrated from 9 sources:
(articles sorted by number of sources associating them with UBE2U) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease. (PubMed id 18069675)9 Sakiyama T....Tsubouchi H. (2008)
|
External Searches for UBE2U gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE2U gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2U gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2U gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBE2U | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBE2U gene:
Search GeneIP for patents involving UBE2U
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2U gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for UBE2U | | OriGene Custom Protein Services for UBE2U | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2U | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2U | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2U | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2U | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2U | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2U |
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 | | | UBE2U Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2U |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2U |
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