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Aliases for UBE2U Gene

Aliases for UBE2U Gene

  • Ubiquitin Conjugating Enzyme E2 U (Putative) 2 3 5
  • Ubiquitin-Conjugating Enzyme E2U (Putative) 2
  • E2 Ubiquitin-Conjugating Enzyme U 4
  • Ubiquitin Carrier Protein U 4
  • Ubiquitin-Protein Ligase U 4
  • EC 4

External Ids for UBE2U Gene

Previous GeneCards Identifiers for UBE2U Gene

  • GC01P064382
  • GC01P064669
  • GC01P062778

Summaries for UBE2U Gene

GeneCards Summary for UBE2U Gene

UBE2U (Ubiquitin Conjugating Enzyme E2 U (Putative)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Ubiquitin mediated proteolysis. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2C.

UniProtKB/Swiss-Prot for UBE2U Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins.

Additional gene information for UBE2U Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2U Gene

Genomics for UBE2U Gene

Regulatory Elements for UBE2U Gene

Enhancers for UBE2U Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H064183 1.2 Ensembl ENCODE 23.5 -2.9 -2868 1 PKNOX1 ZSCAN4 INSM2 ZNF76 ZNF2 ZNF366 ZSCAN5C SCRT2 FOS RCOR1 UBE2U ITGB3BP EFCAB7 JAK1 LINC01359 SLC2A3P2 GC01P064179
GH01H064035 0.3 FANTOM5 63.3 -151.5 -151529 0 UBE2U ROR1 LOC105378772 GC01P064043
GH01H064171 1.2 Ensembl ENCODE 15.4 -14.3 -14297 2 PKNOX1 FOXA2 FEZF1 ZNF302 FOS KLF7 RUNX3 SP3 YY2 JUNB DLEU2L ITGB3BP EFCAB7 UBE2U RPSAP65 LINC01359 ALG6 ROR1-AS1 GC01P064179
GH01H064186 0.6 ENCODE 23.8 -0.1 -78 0 NFIL3 HLF MAFG EBF1 NFE2 SPI1 UBE2U GC01P064179
GH01H064243 0.9 Ensembl ENCODE 15.6 +56.9 56856 0 CTCF ZNF654 NR2F1 RAD21 NR2F2 ETS1 GATA3 SMC3 UBE2U ITGB3BP GC01M064169 GC01M064282
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2U on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2U Gene

64,186,828 bp from pter
64,267,368 bp from pter
80,541 bases
Plus strand

Genomic View for UBE2U Gene

Genes around UBE2U on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2U Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2U Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2U Gene

Proteins for UBE2U Gene

  • Protein details for UBE2U Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 U
    Protein Accession:
    Secondary Accessions:
    • Q8N1D4

    Protein attributes for UBE2U Gene

    321 amino acids
    Molecular mass:
    37741 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2U Gene

    Alternative splice isoforms for UBE2U Gene


neXtProt entry for UBE2U Gene

Post-translational modifications for UBE2U Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UBE2U Gene

Domains & Families for UBE2U Gene

Gene Families for UBE2U Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UBE2U Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family.
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2U: view

Function for UBE2U Gene

Molecular function for UBE2U Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins.

Enzyme Numbers (IUBMB) for UBE2U Gene

Phenotypes From GWAS Catalog for UBE2U Gene

Gene Ontology (GO) - Molecular Function for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2U: view
genes like me logo Genes that share phenotypes with UBE2U: view

Animal Models for UBE2U Gene

MGI Knock Outs for UBE2U:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2U
  • Applied Biological Materials Clones for UBE2U
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UBE2U Gene

Localization for UBE2U Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2U gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IBA --
GO:0005737 cytoplasm IBA --
GO:0033503 HULC complex IBA --
genes like me logo Genes that share ontologies with UBE2U: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for UBE2U Gene

Pathways & Interactions for UBE2U Gene

genes like me logo Genes that share pathways with UBE2U: view

Pathways by source for UBE2U Gene

UniProtKB/Swiss-Prot Q5VVX9-UBE2U_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006281 DNA repair IBA --
GO:0016567 protein ubiquitination IEA --
GO:0016574 histone ubiquitination IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBE2U: view

No data available for SIGNOR curated interactions for UBE2U Gene

Drugs & Compounds for UBE2U Gene

(3) Drugs for UBE2U Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
ATP Nutra Agonist 0

(1) Additional Compounds for UBE2U Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with UBE2U: view

Transcripts for UBE2U Gene

Unigene Clusters for UBE2U Gene

Ubiquitin-conjugating enzyme E2U (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2U
  • Applied Biological Materials Clones for UBE2U
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2U Gene

No ASD Table

Relevant External Links for UBE2U Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2U Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2U Gene

mRNA differential expression in normal tissues according to GTEx for UBE2U Gene

This gene is overexpressed in Testis (x48.5).

NURSA nuclear receptor signaling pathways regulating expression of UBE2U Gene:


SOURCE GeneReport for Unigene cluster for UBE2U Gene:


Evidence on tissue expression from TISSUES for UBE2U Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with UBE2U: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2U Gene

Orthologs for UBE2U Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2U Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBE2U 33 34
  • 98.82 (n)
(Canis familiaris)
Mammalia UBE2U 33 34
  • 83.92 (n)
(Bos Taurus)
Mammalia UBE2U 33 34
  • 82.74 (n)
(Mus musculus)
Mammalia Ube2u 33 16 34
  • 73.3 (n)
(Rattus norvegicus)
Mammalia Ube2u 33
  • 71.41 (n)
(Ornithorhynchus anatinus)
Mammalia UBE2U 34
  • 53 (a)
(Monodelphis domestica)
Mammalia UBE2U 34
  • 29 (a)
(Anolis carolinensis)
Reptilia UBE2U 34
  • 41 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2u 33
  • 56.48 (n)
(Danio rerio)
Actinopterygii zgc:55512 34
  • 34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 34
  • 29 (a)
Species where no ortholog for UBE2U was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2U Gene

Gene Tree for UBE2U (if available)
Gene Tree for UBE2U (if available)

Paralogs for UBE2U Gene

Paralogs for UBE2U Gene

(14) SIMAP similar genes for UBE2U Gene using alignment to 3 proteins: Pseudogenes for UBE2U Gene

genes like me logo Genes that share paralogs with UBE2U: view

Variants for UBE2U Gene

Sequence variations from dbSNP and Humsavar for UBE2U Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000067996 -- 64,264,239(+) AAAAT(A/C)AATTA intron-variant
rs1000082382 -- 64,211,925(+) TGGAA(G/T)ATAAA intron-variant
rs1000242931 -- 64,220,968(+) TTAAA(C/G)TCTTT intron-variant
rs1000253592 -- 64,239,301(+) GTATA(C/T)ATGAG intron-variant
rs1000338121 -- 64,206,624(+) GGAGT(C/T)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2U Gene

Variant ID Type Subtype PubMed ID
esv1385597 CNV deletion 17803354
esv2749096 CNV deletion 23290073
esv2749107 CNV deletion 23290073
esv2749118 CNV deletion 23290073
esv2758938 CNV loss 17122850
nsv477076 CNV novel sequence insertion 20440878
nsv546436 CNV gain 21841781
nsv546437 CNV loss 21841781

Variation tolerance for UBE2U Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2U Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2U Gene

Disorders for UBE2U Gene

Relevant External Links for UBE2U

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBE2U Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2U Gene

Publications for UBE2U Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168. (PMID: 27903633) Guo Y … Huen MS (The Journal of biological chemistry 2017) 3 60

Products for UBE2U Gene

  • Addgene plasmids for UBE2U

Sources for UBE2U Gene

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