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Aliases for UBE2U Gene

Aliases for UBE2U Gene

  • Ubiquitin Conjugating Enzyme E2 U (Putative) 2 3 5
  • Ubiquitin-Conjugating Enzyme E2U (Putative) 2
  • E2 Ubiquitin-Conjugating Enzyme U 4
  • Ubiquitin Carrier Protein U 4
  • Ubiquitin-Protein Ligase U 4
  • EC 2.3.2.23 4

External Ids for UBE2U Gene

Previous GeneCards Identifiers for UBE2U Gene

  • GC01P064382
  • GC01P064669
  • GC01P062778

Summaries for UBE2U Gene

GeneCards Summary for UBE2U Gene

UBE2U (Ubiquitin Conjugating Enzyme E2 U (Putative)) is a Protein Coding gene. Among its related pathways are protein ubiquitylation and Immune System. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2C.

UniProtKB/Swiss-Prot for UBE2U Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2U Gene

Genomics for UBE2U Gene

Regulatory Elements for UBE2U Gene

Enhancers for UBE2U Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around UBE2U on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2U Gene

Chromosome:
1
Start:
64,186,828 bp from pter
End:
64,267,368 bp from pter
Size:
80,541 bases
Orientation:
Plus strand

Genomic View for UBE2U Gene

Genes around UBE2U on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2U Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2U Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2U Gene

Proteins for UBE2U Gene

  • Protein details for UBE2U Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVX9-UBE2U_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 U
    Protein Accession:
    Q5VVX9
    Secondary Accessions:
    • Q8N1D4

    Protein attributes for UBE2U Gene

    Size:
    321 amino acids
    Molecular mass:
    37741 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2U Gene

    Alternative splice isoforms for UBE2U Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2U Gene

Post-translational modifications for UBE2U Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2U Gene

No data available for DME Specific Peptides for UBE2U Gene

Domains & Families for UBE2U Gene

Gene Families for UBE2U Gene

Protein Domains for UBE2U Gene

Suggested Antigen Peptide Sequences for UBE2U Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5VVX9

UniProtKB/Swiss-Prot:

UBE2U_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2U: view

Function for UBE2U Gene

Molecular function for UBE2U Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins.

Enzyme Numbers (IUBMB) for UBE2U Gene

Gene Ontology (GO) - Molecular Function for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0005524 ATP binding IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2U: view
genes like me logo Genes that share phenotypes with UBE2U: view

Animal Models for UBE2U Gene

MGI Knock Outs for UBE2U:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for UBE2U Gene

Localization for UBE2U Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2U Gene COMPARTMENTS Subcellular localization image for UBE2U gene
Compartment Confidence
nucleus 4
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IBA --
GO:0005737 cytoplasm IBA --
GO:0033503 HULC complex IBA --
genes like me logo Genes that share ontologies with UBE2U: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2U Gene

Pathways & Interactions for UBE2U Gene

genes like me logo Genes that share pathways with UBE2U: view

Pathways by source for UBE2U Gene

UniProtKB/Swiss-Prot Q5VVX9-UBE2U_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006281 DNA repair IBA --
GO:0016574 histone ubiquitination IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBE2U: view

No data available for SIGNOR curated interactions for UBE2U Gene

Drugs & Compounds for UBE2U Gene

(3) Drugs for UBE2U Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2U Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2U: view

Transcripts for UBE2U Gene

mRNA/cDNA for UBE2U Gene

Unigene Clusters for UBE2U Gene

Ubiquitin-conjugating enzyme E2U (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2U Gene

No ASD Table

Relevant External Links for UBE2U Gene

GeneLoc Exon Structure for
UBE2U
ECgene alternative splicing isoforms for
UBE2U

Expression for UBE2U Gene

mRNA expression in normal human tissues for UBE2U Gene

mRNA differential expression in normal tissues according to GTEx for UBE2U Gene

This gene is overexpressed in Testis (x48.5).

NURSA nuclear receptor signaling pathways regulating expression of UBE2U Gene:

UBE2U

SOURCE GeneReport for Unigene cluster for UBE2U Gene:

Hs.388746
genes like me logo Genes that share expression patterns with UBE2U: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for UBE2U Gene

Orthologs for UBE2U Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2U Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2U 34
  • 82.74 (n)
  • 73.45 (a)
UBE2U 35
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2U 34
  • 83.92 (n)
  • 74.78 (a)
UBE2U 35
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2u 34
  • 73.3 (n)
  • 57.08 (a)
Ube2u 16
Ube2u 35
  • 37 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2U 34
  • 98.82 (n)
  • 98.23 (a)
UBE2U 35
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2u 34
  • 71.41 (n)
  • 53.33 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2U 35
  • 29 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2U 35
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2U 35
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2u 34
  • 56.48 (n)
  • 48.7 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:55512 35
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 35
  • 29 (a)
OneToMany
Species where no ortholog for UBE2U was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2U Gene

ENSEMBL:
Gene Tree for UBE2U (if available)
TreeFam:
Gene Tree for UBE2U (if available)

Paralogs for UBE2U Gene

Paralogs for UBE2U Gene

(14) SIMAP similar genes for UBE2U Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for UBE2U Gene

genes like me logo Genes that share paralogs with UBE2U: view

Variants for UBE2U Gene

Sequence variations from dbSNP and Humsavar for UBE2U Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7532933 - 64,210,769(+) CTGTA(C/T)AGACT nc-transcript-variant, reference, missense
rs705537 -- 64,237,772(+) AATGA(A/G)GAAAA intron-variant
rs705538 -- 64,258,485(-) ctgtc(A/T)tgggg intron-variant
rs705539 -- 64,259,184(-) attta(C/T)aagaa intron-variant
rs705540 -- 64,260,104(-) CATTG(C/T)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2U Gene

Variant ID Type Subtype PubMed ID
esv1385597 CNV deletion 17803354
esv2749096 CNV deletion 23290073
esv2749107 CNV deletion 23290073
esv2749118 CNV deletion 23290073
esv2758938 CNV loss 17122850
nsv477076 CNV novel sequence insertion 20440878
nsv546436 CNV gain 21841781
nsv546437 CNV loss 21841781

Variation tolerance for UBE2U Gene

Residual Variation Intolerance Score: 66.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.77; 58.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2U Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2U

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2U Gene

Disorders for UBE2U Gene

Relevant External Links for UBE2U

Genetic Association Database (GAD)
UBE2U
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2U

No disorders were found for UBE2U Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2U Gene

Publications for UBE2U Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65

Products for UBE2U Gene

Sources for UBE2U Gene

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