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Aliases for UBE2U Gene

Aliases for UBE2U Gene

  • Ubiquitin-Conjugating Enzyme E2U (Putative) 2 3
  • Ubiquitin Carrier Protein U 4
  • Ubiquitin-Protein Ligase U 4
  • EC 6.3.2.19 4

External Ids for UBE2U Gene

Summaries for UBE2U Gene

GeneCards Summary for UBE2U Gene

UBE2U (Ubiquitin-Conjugating Enzyme E2U (Putative)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2B.

UniProtKB/Swiss-Prot for UBE2U Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2U Gene

Genomics for UBE2U Gene

Genomic Location for UBE2U Gene

Start:
64,203,603 bp from pter
End:
64,267,368 bp from pter
Size:
63,766 bases
Orientation:
Plus strand

Genomic View for UBE2U Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2U Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2U Gene

Regulatory Elements for UBE2U Gene

Proteins for UBE2U Gene

  • Protein details for UBE2U Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VVX9-UBE2U_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 U
    Protein Accession:
    Q5VVX9
    Secondary Accessions:
    • Q8N1D4

    Protein attributes for UBE2U Gene

    Size:
    321 amino acids
    Molecular mass:
    37741 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2U Gene

    Alternative splice isoforms for UBE2U Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2U Gene

Proteomics data for UBE2U Gene at MOPED

Post-translational modifications for UBE2U Gene

No Post-translational modifications

Other Protein References for UBE2U Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for UBE2U Gene

Domains for UBE2U Gene

Gene Families for UBE2U Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2U Gene

UniProtKB/Swiss-Prot:

UBE2U_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • Q5VVX9
genes like me logo Genes that share domains with UBE2U: view

Function for UBE2U Gene

Molecular function for UBE2U Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Catalyzes the covalent attachment of ubiquitin to other proteins.

Enzyme Numbers (IUBMB) for UBE2U Gene

Gene Ontology (GO) - Molecular Function for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity IBA --
genes like me logo Genes that share ontologies with UBE2U: view

Phenotypes for UBE2U Gene

GenomeRNAi human phenotypes for UBE2U:
genes like me logo Genes that share phenotypes with UBE2U: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UBE2U Gene

Localization for UBE2U Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2U Gene COMPARTMENTS Subcellular localization image for UBE2U gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IBA --
GO:0005737 cytoplasm IBA --
GO:0033503 HULC complex IBA --
genes like me logo Genes that share ontologies with UBE2U: view

Pathways for UBE2U Gene

genes like me logo Genes that share pathways with UBE2U: view

UniProtKB/Swiss-Prot Q5VVX9-UBE2U_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2U Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006281 DNA repair IBA --
GO:0016567 protein ubiquitination --
GO:0016574 histone ubiquitination IBA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBE2U: view

Compounds for UBE2U Gene

(4) HMDB Compounds for UBE2U Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2U: view

Transcripts for UBE2U Gene

mRNA/cDNA for UBE2U Gene

Unigene Clusters for UBE2U Gene

Ubiquitin-conjugating enzyme E2U (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2U Gene

No ASD Table

Relevant External Links for UBE2U Gene

GeneLoc Exon Structure for
UBE2U
ECgene alternative splicing isoforms for
UBE2U

Expression for UBE2U Gene

mRNA expression in normal human tissues for UBE2U Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2U Gene

This gene is overexpressed in Testis (48.5).

SOURCE GeneReport for Unigene cluster for UBE2U Gene Hs.388746

genes like me logo Genes that share expressions with UBE2U: view

Orthologs for UBE2U Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2U Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2U 36
  • 98.82 (n)
  • 98.23 (a)
UBE2U 37
  • 76 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2U 36
  • 82.74 (n)
  • 73.45 (a)
UBE2U 37
  • 53 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2U 36
  • 83.92 (n)
  • 74.78 (a)
UBE2U 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2u 36
  • 73.3 (n)
  • 57.08 (a)
Ube2u 16
Ube2u 37
  • 37 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2U 37
  • 29 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2U 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2u 36
  • 71.41 (n)
  • 53.33 (a)
lizard
(Anolis carolinensis)
Reptilia UBE2U 37
  • 41 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2u 36
  • 56.48 (n)
  • 48.7 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:55512 37
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 37
  • 29 (a)
OneToMany
Species with no ortholog for UBE2U:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2U Gene

ENSEMBL:
Gene Tree for UBE2U (if available)
TreeFam:
Gene Tree for UBE2U (if available)

Paralogs for UBE2U Gene

Paralogs for UBE2U Gene

Selected SIMAP similar genes for UBE2U Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for UBE2U Gene

genes like me logo Genes that share paralogs with UBE2U: view

Variants for UBE2U Gene

Sequence variations from dbSNP and Humsavar for UBE2U Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs697435 -- 64,262,389(-) ttaag(C/T)agagg intron-variant
rs705537 -- 64,237,772(+) AATGA(A/G)GAAAA intron-variant
rs705538 -- 64,258,485(-) ctgtc(A/T)tgggg intron-variant
rs705539 -- 64,259,184(-) attta(C/T)aagaa intron-variant
rs705540 -- 64,260,104(-) CATTG(C/T)ATGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2U Gene

Variant ID Type Subtype PubMed ID
nsv871805 CNV Loss 21882294
dgv55e1 CNV Complex 17122850
esv2749096 CNV Deletion 23290073
esv2749107 CNV Deletion 23290073
esv2749118 CNV Deletion 23290073
esv1385597 CNV Deletion 17803354

Relevant External Links for UBE2U Gene

HapMap Linkage Disequilibrium report
UBE2U

Disorders for UBE2U Gene

Relevant External Links for UBE2U

Genetic Association Database (GAD)
UBE2U
genes like me logo Genes that share disorders with UBE2U: view

No data available for UniProtKB/Swiss-Prot for UBE2U Gene

Publications for UBE2U Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3

Products for UBE2U Gene

Sources for UBE2U Gene

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