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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2T Gene

protein-coding   GIFtS: 60
GCID: GC01M202300

Ubiquitin-Conjugating Enzyme E2T (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2T (Putative)1 2     HSPC150 Protein Similar To Ubiquitin-Conjugating Enzyme2
Cell Proliferation-Inducing Gene 50 Protein2 3     Ubiquitin Conjugating Enzyme2
Ubiquitin Carrier Protein T2 3     Ubiquitin-Conjugating Enzyme E2 T2
Ubiquitin-Protein Ligase T2 3     EC 6.3.2.193
PIG502     HSPC1505

External Ids:    HGNC: 250091   Entrez Gene: 290892   Ensembl: ENSG000000771527   OMIM: 6105385   UniProtKB: Q9NPD83   

Export aliases for UBE2T gene to outside databases

Previous GC identifers: GC01M199033 GC01M200567 GC01M173466


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2T Gene:
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is
transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a
ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 (PubMed
16916645)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UBE2T Gene: 
UBE2T (ubiquitin-conjugating enzyme E2T (putative)) is a protein-coding gene. Diseases associated with UBE2T include fanconi's anemia, and hypoxia, and among its related super-pathways are Nucleotide Excision Repair and Fanconi's Anaemia Pathway. GO annotations related to this gene include chromatin binding and ubiquitin protein ligase binding. An important paralog of this gene is UBE2NL.

UniProtKB/Swiss-Prot: UBE2T_HUMAN, Q9NPD8
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating
enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing
monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and
FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination
using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked
polyubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2T gene promoter:
         MEF-2A   FAC1   HFH-1   COMP1   Pax-6   MyoD   AP-4   NF-kappaB1   HNF-3beta   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2T promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2T

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2T


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

UBE2T Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2T gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202300:  view genomic region     (about GC identifiers)

Start:
202,300,785 bp from pter      End:
202,311,108 bp from pter
Size:
10,324 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBE2T_HUMAN, Q9NPD8 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 T  
Size: 197 amino acids; 22521 Da
Subunit: Interacts with FANCL and BRCA1
Subcellular location: Nucleus. Note=Accumulates to chromatin
1 PDB 3D structure from and Proteopedia for UBE2T:
1YH2 (3D)    
Secondary accessions: Q2TU36

Explore the universe of human proteins at neXtProt for UBE2T: NX_Q9NPD8

Explore proteomics data for UBE2T at MOPED 

Post-translational modifications:

  • UniProtKB: Auto-ubiquitinated. Effects of auto-monoubiquitination at Lys-91 and Lys-182 are unclear: according to a report,
    monoubiquitination inactivates E2 enzyme activity (PubMed:16916645). In contrast, according to another report,
    autoubiquitination does not affect E2 enzyme activity (PubMed:19111657)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NPD8

  • UBE2T Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2T Protein Expression
    REFSEQ proteins: NP_054895.1  
    ENSEMBL proteins: 
     ENSP00000356243  
    Reactome Protein details: Q9NPD8
    Human Recombinant Protein Products for UBE2T: 
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    Novus Biologicals UBE2T Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UBE2T
    Cloud-Clone Corp. Proteins for UBE2T 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS17938197
    GO:0005654nucleoplasm TAS--

    UBE2T for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q9NPD8

    ProtoNet protein and cluster: Q9NPD8

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2T_HUMAN, Q9NPD8
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2T for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2T_HUMAN, Q9NPD8
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
    monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating
    enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing
    monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and
    FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination
    using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked
    polyubiquitination
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Induction: Down-regulated following hypoxia. Up-regulated in breast cancers

         Enzyme Number (IUBMB): EC 6.3.2.191

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA17938197
    GO:0004842ubiquitin-protein ligase activity IDA16916645
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0031625ubiquitin protein ligase binding IPI16916645
         
    UBE2T for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2T:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2T 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2T

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2T 
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    miRNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2T About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Nucleotide Excision Repair
    DNA Repair0.46
    2Fanconi Anemia pathway
    Fanconi Anemia pathway0.43
    3DNA Damage
    DNA Damage0.32
    4Protein Stability
    Protein Stability
    5Gastric cancer network 2
    Gastric cancer network 2

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for UBE2T
        DNA Damage
    Protein Stability

    1 BioSystems Pathway for UBE2T
        Gastric cancer network 2

    2        Reactome Pathways for UBE2T
        DNA Repair
    Fanconi Anemia pathway


    1         Kegg Pathway  (Kegg details for UBE2T):
        Fanconi anemia pathway

    UniProtKB/Swiss-Prot: UBE2T_HUMAN, Q9NPD8
    Pathway: Protein modification; protein ubiquitination


    UBE2T for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2T

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/46 Interacting proteins for UBE2T (Q9NPD83 ENSP000003562434) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237071P143733, ENSP000004052294I2D: score=2 STRING: ENSP00000405229
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    ENSG00000234495P143733I2D: score=2 
    TRIM27P143733I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006513protein monoubiquitination IDA16916645
    GO:0006974response to DNA damage stimulus IMP16916645
    GO:0035519protein K29-linked ubiquitination IDA--
    GO:0044314protein K27-linked ubiquitination IDA--

    UBE2T for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2T

    Search CenterWatch for drugs/clinical trials and news about UBE2T

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2T gene: 
    NM_014176.3  

    Unigene Cluster for UBE2T:

    Ubiquitin-conjugating enzyme E2T (putative)
    Hs.5199  [show with all ESTs]
    Unigene Representative Sequence: BF690859
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367274(uc001gxx.4) ENST00000487227 ENST00000460852
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2T
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2T

    Additional mRNA sequence: 

    AB032931.1 AF160215.1 AF161499.1 AK000504.1 AY542309.1 BC004152.2 BC019284.1 

    10 DOTS entries:

    DT.448219  DT.95326922  DT.95275330  DT.121353904  DT.95275329  DT.121354001  DT.95219442  DT.95275324 
    DT.91749377  DT.100782806 

    24/167 AceView cDNA sequences (see all 167):

    AI032574 AW376655 BE778001 AA046828 CA424899 BC019284 AF160215 BU631864 
    BF032589 AI140513 AI146665 BU634367 BC004152 BQ015257 BQ430814 AA046871 
    AI791736 AK000504 BI087825 BQ219156 AI377004 AA705231 CN479657 AI056896 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2T    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                          -                                       
    SP2:                          -                                       
    SP3:                          -     -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for UBE2T

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2T expression in normal human tissues (normalized intensities)      UBE2T embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGACAGAA
    UBE2T Expression
    About this image


    UBE2T expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone

    See UBE2T Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2T

    SOURCE GeneReport for Unigene cluster: Hs.5199
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2T: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2T

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2T gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2t1 , 5 ubiquitin-conjugating enzyme E2T (putative)1, 5 84.18(n)1
    85.71(a)1
      1 (58.24 cM)5
    671961  NM_026024.21  NP_080300.11 
     1349625655 
    chicken
    (Gallus gallus)
    Aves UBE2T1 ubiquitin-conjugating enzyme E2T (putative) 68.74(n)
    71.5(a)
      421149  XM_419230.3  XP_419230.2 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2T6
    ubiquitin-conjugating enzyme E2T (putative)
    60(a)
    1 ↔ 1
    4(132945037-132963599)
    African clawed frog
    (Xenopus laevis)
    Amphibia hspc150-prov2 HSPC150 protein similar to ubiquitin-conjugating enzyme 76.53(n)    BC044029.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj86h112 Transcribed sequence with moderate similarity to protein more 75.52(n)    BM531174.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC136
    Ubiquitin-conjugating enzyme involved in the error...
    45(a)
    1 → many
    IV(629876-630605)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC371 putative ubiquitin-conjugating enzyme E2 37 57.05(n)
    56.38(a)
      822045  NM_113362.1  NP_566751.1 
    rice
    (Oryza sativa)
    Liliopsida Os.236942 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.54(n)    AK063933.1 


    ENSEMBL Gene Tree for UBE2T (if available)
    TreeFam Gene Tree for UBE2T (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2T gene
    UBE2NL2  UBE2N2  
    18/21 SIMAP similar genes for UBE2T using alignment to 1 protein entry:     UBE2T_HUMAN(see all similar genes):
    UBE2N    UBE2D2    UBE2NL    UBE2D4    UBE2A    UBE2D1
    UBE2D3    UBE2E2    UBE2H    UBE2B    UBE2E3    UBE2E1
    UBE2L3    UBE2K    UBE2G1    UBE2L6    UBE2S    UBE2I

    UBE2T for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/239 SNPs in UBE2T are shown (see all 239)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912739341,2
    --202300289(+) GTTTGA/GCACCG 1 -- int10--------
    rs1447708551,2
    --202300469(+) AAATGA/GAAGTT 1 -- int10--------
    rs1824141731,2
    --202300567(+) CCCACA/GTTATT 1 -- int10--------
    rs1481409661,2
    --202300748(+) GGCCAC/GTTTAC 1 -- int10--------
    rs1424144161,2
    --202300761(+) CCAGAA/CACACA 1 -- int10--------
    rs1874950571,2
    C--202300915(+) TTAGAC/TCACCT 1 -- ut310--------
    rs2002280641,2
    C--202300928(+) GCAAAG/CAACAC 1 -- ut311Minor allele frequency- C:0.00EU 1323
    rs1999899111,2
    --202300936(+) CACATC/TAACTA 1 -- ut310--------
    rs1920115301,2
    C--202301153(+) ATGAAA/GCTCTG 1 -- int10--------
    rs7888011,2
    C,F,O,A,H--202301291(-) TTAAAT/CAGCAG 1 -- int124Minor allele frequency- C:0.28NA EA NS WA CSA 1360

    HapMap Linkage Disequilibrium report for UBE2T (202300785 - 202311108 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2T:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721572CNV Deletion23290073


    Human Gene Mutation Database (HGMD): UBE2T
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2T
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2T

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610538    OMIM disorders: --

    5 diseases for UBE2T:    About MalaCards
    fanconi's anemia    hypoxia    anemia    lung cancer
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for UBE2T:
    Fanconi's anemia

    UBE2T for disorders           About GeneDecksing


    Export disorders for UBE2T gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2T gene, integrated from 9 sources (see all 40):
    (articles sorted by number of sources associating them with UBE2T)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
    2. Ubiquitination and downregulation of BRCA1 by ubiquit in-conjugating enzyme E2T overexpression in human breast cancer cells. (PubMed id 19887602)1, 2, 9 Ueki T....Katagiri T. (2009)
    3. Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T. (PubMed id 21722982)1, 2 Ramaekers C.H.... Wouters B.G. (2011)
    4. Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway. (PubMed id 21775430)1, 2 Hodson C.... Walden H. (2011)
    5. FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. (PubMed id 19589784)1, 2 Longerich S....Sung P. (2009)
    6. Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. (PubMed id 19111657)1, 2 Alpi A.F....Patel K.J. (2008)
    7. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. (PubMed id 17938197)1, 2 Alpi A....Patel K.J. (2007)
    8. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. (PubMed id 16916645)1, 2 Machida Y.J....Dutta A. (2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29089 HGNC: 25009 AceView: HSPC150 Ensembl:ENSG00000077152 euGenes: HUgn29089
    ECgene: UBE2T Kegg: 29089 H-InvDB: UBE2T

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2T Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2T gene:
    Search GeneIP for patents involving UBE2T

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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