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Aliases for UBE2T Gene

Aliases for UBE2T Gene

  • Ubiquitin-Conjugating Enzyme E2T 2 3
  • Cell Proliferation-Inducing Gene 50 Protein 3 4
  • Ubiquitin Carrier Protein T 3 4
  • Ubiquitin-Protein Ligase T 3 4
  • HSPC150 3 6
  • HSPC150 Protein Similar To Ubiquitin-Conjugating Enzyme 3
  • Ubiquitin-Conjugating Enzyme E2T (Putative) 3
  • Ubiquitin-Conjugating Enzyme E2 T 3
  • Ubiquitin Conjugating Enzyme 3
  • EC 6.3.2.19 4
  • PIG50 3

External Ids for UBE2T Gene

Previous GeneCards Identifiers for UBE2T Gene

  • GC01M199033
  • GC01M200567
  • GC01M173466

Summaries for UBE2T Gene

Entrez Gene Summary for UBE2T Gene

  • The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008]

GeneCards Summary for UBE2T Gene

UBE2T (Ubiquitin-Conjugating Enzyme E2T) is a Protein Coding gene. Among its related pathways are Remodeling of Adherens Junctions and Protein Stability. GO annotations related to this gene include chromatin binding and ubiquitin protein ligase binding. An important paralog of this gene is UBE2N.

UniProtKB/Swiss-Prot for UBE2T Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer Lys-11-, Lys-27-, Lys-48- and Lys-63-linked polyubiquitination.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2T Gene

Genomics for UBE2T Gene

Regulatory Elements for UBE2T Gene

Genomic Location for UBE2T Gene

Start:
202,331,657 bp from pter
End:
202,341,980 bp from pter
Size:
10,324 bases
Orientation:
Minus strand

Genomic View for UBE2T Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2T Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2T Gene

Proteins for UBE2T Gene

  • Protein details for UBE2T Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPD8-UBE2T_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 T
    Protein Accession:
    Q9NPD8
    Secondary Accessions:
    • Q2TU36

    Protein attributes for UBE2T Gene

    Size:
    197 amino acids
    Molecular mass:
    22521 Da
    Quaternary structure:
    • Interacts with FANCL and BRCA1.

    Three dimensional structures from OCA and Proteopedia for UBE2T Gene

neXtProt entry for UBE2T Gene

Proteomics data for UBE2T Gene at MOPED

Post-translational modifications for UBE2T Gene

  • Auto-ubiquitinated. Effects of auto-monoubiquitination at Lys-91 and Lys-182 are unclear: according to a report, monoubiquitination inactivates E2 enzyme activity (PubMed:16916645). In contrast, according to another report, autoubiquitination does not affect E2 enzyme activity (PubMed:19111657).
  • Ubiquitination at Lys48, Lys91, and Lys182
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2T Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2T (UBE2T)

No data available for DME Specific Peptides for UBE2T Gene

Domains for UBE2T Gene

Gene Families for UBE2T Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2T Gene

Suggested Antigen Peptide Sequences for UBE2T Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPD8

UniProtKB/Swiss-Prot:

UBE2T_HUMAN :
  • Q9NPD8
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2T: view

Function for UBE2T Gene

Molecular function for UBE2T Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer Lys-11-, Lys-27-, Lys-48- and Lys-63-linked polyubiquitination.
UniProtKB/Swiss-Prot Induction: Down-regulated following hypoxia. Up-regulated in breast cancers.

Enzyme Numbers (IUBMB) for UBE2T Gene

Gene Ontology (GO) - Molecular Function for UBE2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IDA 17938197
GO:0004842 ubiquitin-protein transferase activity IDA 16916645
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2T: view

Phenotypes for UBE2T Gene

GenomeRNAi human phenotypes for UBE2T:
genes like me logo Genes that share phenotypes with UBE2T: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2T

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UBE2T Gene

Localization for UBE2T Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2T Gene

Nucleus. Note=Accumulates to chromatin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2T Gene COMPARTMENTS Subcellular localization image for UBE2T gene
Compartment Confidence
nucleus 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for UBE2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 17938197
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBE2T: view

Pathways for UBE2T Gene

genes like me logo Genes that share pathways with UBE2T: view

Pathways by source for UBE2T Gene

2 Cell Signaling Technology pathways for UBE2T Gene
1 BioSystems pathway for UBE2T Gene
2 Reactome pathways for UBE2T Gene
1 KEGG pathway for UBE2T Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9NPD8-UBE2T_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2T Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006513 protein monoubiquitination IDA 16916645
GO:0006974 cellular response to DNA damage stimulus IMP 16916645
GO:0035519 protein K29-linked ubiquitination IDA 20061386
GO:0044314 protein K27-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2T: view

Transcripts for UBE2T Gene

mRNA/cDNA for UBE2T Gene

Unigene Clusters for UBE2T Gene

Ubiquitin-conjugating enzyme E2T (putative):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2T

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2T Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
SP1: -
SP2: -
SP3: - -
SP4:

Relevant External Links for UBE2T Gene

GeneLoc Exon Structure for
UBE2T
ECgene alternative splicing isoforms for
UBE2T

Expression for UBE2T Gene

mRNA expression in normal human tissues for UBE2T Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2T Gene

SOURCE GeneReport for Unigene cluster for UBE2T Gene Hs.5199

genes like me logo Genes that share expressions with UBE2T: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2T Gene

Orthologs for UBE2T Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2T Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2T 35
  • 99.83 (n)
  • 99.49 (a)
UBE2T 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2T 35
  • 80.51 (n)
  • 82.56 (a)
UBE2T 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2T 35
  • 90.52 (n)
  • 89.85 (a)
UBE2T 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2t 35
  • 84.18 (n)
  • 85.71 (a)
Ube2t 16
Ube2t 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2T 36
  • 31 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2T 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2t 35
  • 83.33 (n)
  • 82.65 (a)
chicken
(Gallus gallus)
Aves UBE2T 35
  • 68.74 (n)
  • 71.5 (a)
UBE2T 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2T 36
  • 59 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hspc150-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3516 35
ube2t 35
  • 69.44 (n)
  • 73.33 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10911 35
zebrafish
(Danio rerio)
Actinopterygii ube2t 35
  • 71.76 (n)
  • 76.43 (a)
ube2t 36
  • 52 (a)
OneToOne
wufj86h11 35
fruit fly
(Drosophila melanogaster)
Insecta ben 36
  • 48 (a)
OneToMany
CG3473 36
  • 46 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC13 36
  • 44 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os.23694 35
Os01g0605300 35
  • 60.27 (n)
  • 60.27 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3070 36
  • 49 (a)
OneToOne
Species with no ortholog for UBE2T:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2T Gene

ENSEMBL:
Gene Tree for UBE2T (if available)
TreeFam:
Gene Tree for UBE2T (if available)

Paralogs for UBE2T Gene

Paralogs for UBE2T Gene

Selected SIMAP similar genes for UBE2T Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBE2T: view

Variants for UBE2T Gene

Sequence variations from dbSNP and Humsavar for UBE2T Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14451 -- 202,335,740(-) GCTTC(A/G/T)CGTCT reference, synonymous-codon
rs705733 -- 202,338,281(-) gagca(C/T)accat intron-variant
rs705734 -- 202,338,333(-) ctgag(A/G)cagga intron-variant
rs788784 -- 202,341,415(-) ATTTT(C/T)AGTAG intron-variant
rs788785 -- 202,338,459(-) tggat(C/T)acctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2T Gene

Variant ID Type Subtype PubMed ID
esv2721572 CNV Deletion 23290073

Relevant External Links for UBE2T Gene

HapMap Linkage Disequilibrium report
UBE2T
Human Gene Mutation Database (HGMD)
UBE2T

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2T Gene

Disorders for UBE2T Gene

(1) University of Copenhagen DISEASES for UBE2T Gene

genes like me logo Genes that share disorders with UBE2T: view

No data available for UniProtKB/Swiss-Prot for UBE2T Gene

Publications for UBE2T Gene

  1. Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. (PMID: 19887602) Ueki T. … Katagiri T. (Cancer Res. 2009) 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  3. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. (PMID: 16916645) Machida Y.J. … Dutta A. (Mol. Cell 2006) 2 3 4
  4. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. (PMID: 17938197) Alpi A. … Patel K.J. (Mol. Cell. Biol. 2007) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for UBE2T Gene

  • Addgene plasmids for UBE2T

Sources for UBE2T Gene

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