Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UBE2T Gene

protein-coding   GIFtS: 60
GCID: GC01M202300

Ubiquitin-Conjugating Enzyme E2T (Putative)

  Search for UBE2T
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin-Conjugating Enzyme E2T (Putative)1 2     HSPC150 Protein Similar To Ubiquitin-Conjugating Enzyme2
Cell Proliferation-Inducing Gene 50 Protein2 3     Ubiquitin Conjugating Enzyme2
Ubiquitin Carrier Protein T2 3     Ubiquitin-Conjugating Enzyme E2 T2
Ubiquitin-Protein Ligase T2 3     EC 6.3.2.193
PIG502     HSPC1505

External Ids:    HGNC: 250091   Entrez Gene: 290892   Ensembl: ENSG000000771527   OMIM: 6105385   UniProtKB: Q9NPD83   

Export aliases for UBE2T gene to outside databases

Previous GC identifers: GC01M199033 GC01M200567 GC01M173466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UBE2T Gene:
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is
transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a
ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 (PubMed
16916645)).(supplied by OMIM, Mar 2008)

GeneCards Summary for UBE2T Gene:
UBE2T (ubiquitin-conjugating enzyme E2T (putative)) is a protein-coding gene. GO annotations related to this gene include chromatin binding and ubiquitin protein ligase binding. An important paralog of this gene is UBE2NL.

UniProtKB/Swiss-Prot: UBE2T_HUMAN, Q9NPD8
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating
enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing
monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and
FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination
using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked
polyubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2T gene promoter:
         MEF-2A   FAC1   HFH-1   COMP1   Pax-6   MyoD   AP-4   NF-kappaB1   HNF-3beta   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2T promoter sequence
   Search Chromatin IP Primers for UBE2T

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2T


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32.1   Ensembl cytogenetic band:  1q32.1   HGNC cytogenetic band: 1q32.1

UBE2T Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2T gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M202300:  view genomic region     (about GC identifiers)

Start:
202,300,785 bp from pter      End:
202,311,108 bp from pter
Size:
10,324 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBE2T_HUMAN, Q9NPD8 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 T  
Size: 197 amino acids; 22521 Da
Subunit: Interacts with FANCL and BRCA1
2 PDB 3D structures from and Proteopedia for UBE2T:
1YH2 (3D)        4CCG (3D)    
Secondary accessions: Q2TU36

Explore the universe of human proteins at neXtProt for UBE2T: NX_Q9NPD8

Explore proteomics data for UBE2T at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated. Effects of auto-monoubiquitination at Lys-91 and Lys-182 are unclear: according to a report,
    monoubiquitination inactivates E2 enzyme activity (PubMed:16916645). In contrast, according to another report,
    autoubiquitination does not affect E2 enzyme activity (PubMed:19111657)1
  • Ubiquitination2 at Lys48, Lys91, Lys182
  • Modification sites at PhosphoSitePlus

  • See UBE2T Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_054895.1  
    ENSEMBL proteins: 
     ENSP00000356243  
    Reactome Protein details: Q9NPD8

    UBE2T Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UBE2T
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for UBE2T
    OriGene Protein Over-expression Lysate for UBE2T
    OriGene MassSpec for UBE2T
    OriGene Custom Protein Services for UBE2T
    GenScript Custom Purified and Recombinant Proteins Services for UBE2T
    Novus Biologicals UBE2T Proteins
    Novus Biologicals UBE2T Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBE2T
    Cloud-Clone Corp. Proteins for UBE2T

     
    Search eBioscience for Proteins for UBE2T 

    UBE2T Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UBE2T
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for UBE2T 
    OriGene Antibodies for UBE2T
    OriGene Custom Antibody Services for UBE2T
    Novus Biologicals UBE2T Antibodies
    Abcam antibodies for UBE2T
    Cloud-Clone Corp. Antibodies for UBE2T
    ThermoFisher Antibodies for UBE2T
    LSBio Antibodies in human, mouse, rat for UBE2T

    UBE2T Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBE2T
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBE2T
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBE2T
    Cloud-Clone Corp. CLIAs for UBE2T
    Search eBioscience for ELISAs for UBE2T 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q9NPD8

    ProtoNet protein and cluster: Q9NPD8

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2T_HUMAN, Q9NPD8
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2T           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2T_HUMAN, Q9NPD8
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
    monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating
    enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing
    monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and
    FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination
    using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked
    polyubiquitination
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Induction: Down-regulated following hypoxia. Up-regulated in breast cancers

         Enzyme Number (IUBMB): EC 6.3.2.191

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding IDA17938197
    GO:0004842ubiquitin-protein ligase activity IDA16916645
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0031625ubiquitin protein ligase binding IPI16916645
         
    Find genes that share ontologies with UBE2T           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2T:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2T
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2T

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2T
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2T

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat UBE2T using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UBE2T
    SwitchGear 3'UTR luciferase reporter plasmidUBE2T 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBE2T
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2T

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBE2T

    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2T (see all 6)
    OriGene ORF clones in mouse, rat for UBE2T
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2T (NM_014176)
    Sino Biological Human cDNA Clone for UBE2T
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2T
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2T
    Addgene plasmids for UBE2T 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBE2T
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBE2T 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2T


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBE2T_HUMAN, Q9NPD8: Nucleus. Note=Accumulates to chromatin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    mitochondrion2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus TAS17938197
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with UBE2T           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UBE2T About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1DNA Repair
    DNA Repair0.45
    2Cell Cycle / Checkpoint Control
    DNA Damage0.32
    3Protein Stability
    Protein Stability
    4Gastric cancer network 2
    Gastric cancer network 2
    5Fanconi Anemia pathway (REACTOME)
    Fanconi Anemia pathway


    Find genes that share SuperPaths with UBE2T           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2T
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for UBE2T
        DNA Damage
    Protein Stability

    1 BioSystems Pathway for UBE2T
        Gastric cancer network 2


    1 Reactome Pathway for UBE2T
        Fanconi Anemia pathway


    1 Kegg Pathway  (Kegg details for UBE2T):
        Fanconi anemia pathway

    UniProtKB/Swiss-Prot: UBE2T_HUMAN, Q9NPD8
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2T: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2T

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2T (Q9NPD83 ENSP000003562434) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237071P143733, ENSP000004052294I2D: score=2 STRING: ENSP00000405229
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    ENSG00000234495P143733I2D: score=2 
    TRIM27P143733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006513protein monoubiquitination IDA16916645
    GO:0006974cellular response to DNA damage stimulus IMP16916645
    GO:0035519protein K29-linked ubiquitination IDA--
    GO:0044314protein K27-linked ubiquitination IDA--

    Find genes that share ontologies with UBE2T           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2T



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UBE2T gene: 
    NM_014176.3  

    Unigene Cluster for UBE2T:

    Ubiquitin-conjugating enzyme E2T (putative)
    Hs.5199  [show with all ESTs]
    Unigene Representative Sequence: BF690859
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367274(uc001gxx.4) ENST00000487227 ENST00000460852
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBE2T using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UBE2T
    SwitchGear 3'UTR luciferase reporter plasmidUBE2T 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBE2T
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2T
    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2T (see all 6)
    OriGene ORF clones in mouse, rat for UBE2T
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2T (NM_014176)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2T
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2T
    Addgene plasmids for UBE2T 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBE2T
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2T
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2T
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2T
      QuantiFast Probe-based Assays in human, mouse, rat UBE2T

    Additional mRNA sequence: 

    AB032931.1 AF160215.1 AF161499.1 AK000504.1 AY542309.1 BC004152.2 BC019284.1 

    10 DOTS entries:

    DT.448219  DT.95326922  DT.95275330  DT.121353904  DT.95275329  DT.121354001  DT.95219442  DT.95275324 
    DT.91749377  DT.100782806 

    Selected AceView cDNA sequences (see all 167):

    BF032589 BE778001 AF160215 AI791736 BU631864 BU634367 AI056896 BI087825 
    AW376655 AK000504 CA424899 AI146665 BC019284 AI032574 BQ219156 BQ430814 
    AI377004 AA046871 AI140513 BQ015257 AA046828 BC004152 CN479657 AA705231 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2T    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7
    SP1:                          -                                       
    SP2:                          -                                       
    SP3:                          -     -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for UBE2T

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UBE2T expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGACAGAA
    UBE2T Expression
    About this image


    UBE2T expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Gonad (Reproductive System)    fully expand to see all 2 entries
             Primordial Germ Cells Primitive Gonad
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Neural Tube (Nervous System)
             Mesencephalic Ventricular Zone
    UBE2T Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2T Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.5199
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2T: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2T
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2T
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2T
    QuantiTect SYBR Green Assays in human, mouse, rat UBE2T
    QuantiFast Probe-based Assays in human, mouse, rat UBE2T
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2T

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2T gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2t1 , 5 ubiquitin-conjugating enzyme E2T (putative)1, 5 84.18(n)1
    85.71(a)1
      1 (58.24 cM)5
    671961  NM_001278115.11  NP_001265044.11 
     1349625655 
    chicken
    (Gallus gallus)
    Aves UBE2T1 ubiquitin-conjugating enzyme E2T (putative) 68.74(n)
    71.5(a)
      421149  XM_419230.4  XP_419230.2 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2T6
    ubiquitin-conjugating enzyme E2T (putative)
    59(a)
    1 ↔ 1
    4(132945037-132963599)
    African clawed frog
    (Xenopus laevis)
    Amphibia hspc150-prov2 HSPC150 protein similar to ubiquitin-conjugating enzyme 76.53(n)    BC044029.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj86h112 Transcribed sequence with moderate similarity to protein more 75.52(n)    BM531174.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ben6
    CG34736
    --
    48(a)
    46(a)
    1 ↔ many
    1 ↔ many
    X(13890387-13893841)
    2L(14563072-14563726)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC136
    Ubiquitin-conjugating enzyme involved in the error...
    44(a)
    1 → many
    IV(629876-630605) YDR092W
    rice
    (Oryza sativa)
    Liliopsida Os.236942 Oryza sativa (japonica cultivar-group) cDNA clone0 more 76.54(n)    AK063933.1 


    ENSEMBL Gene Tree for UBE2T (if available)
    TreeFam Gene Tree for UBE2T (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UBE2T gene
    UBE2NL2  UBE2N2  
    Selected SIMAP similar genes for UBE2T using alignment to 1 protein entry:     UBE2T_HUMAN(see all similar genes):
    UBE2N    UBE2D2    UBE2NL    UBE2D4    UBE2A    UBE2D1
    UBE2D3    UBE2E2    UBE2H    UBE2B    UBE2E3    UBE2E1
    UBE2L3    UBE2K    UBE2G1    UBE2L6    UBE2S    UBE2I

    Find genes that share paralogs with UBE2T           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UBE2T (see all 239)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1912739341,2
    --202300289(+) GTTTGA/GCACCG 1 -- int10--------
    rs1447708551,2
    --202300469(+) AAATGA/GAAGTT 1 -- int10--------
    rs1824141731,2
    --202300567(+) CCCACA/GTTATT 1 -- int10--------
    rs1481409661,2
    --202300748(+) GGCCAC/GTTTAC 1 -- int10--------
    rs1424144161,2
    --202300761(+) CCAGAA/CACACA 1 -- int10--------
    rs1874950571,2
    C--202300915(+) TTAGAC/TCACCT 1 -- ut310--------
    rs2002280641,2
    C--202300928(+) GCAAAG/CAACAC 1 -- ut311Minor allele frequency- C:0.00EU 1323
    rs1999899111,2
    --202300936(+) CACATC/TAACTA 1 -- ut310--------
    rs1920115301,2
    C--202301153(+) ATGAAA/GCTCTG 1 -- int10--------
    rs7888011,2
    C,F,O,A,H--202301291(-) TTAAAT/CAGCAG 1 -- int124Minor allele frequency- C:0.28NA EA NS WA CSA 1360

    HapMap Linkage Disequilibrium report for UBE2T (202300785 - 202311108 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2T:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721572CNV Deletion23290073

    Human Gene Mutation Database (HGMD): UBE2T
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2T
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2T

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610538    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for UBE2T:
    Fanconi's anemia

    Find genes that share disorders with UBE2T           About GenesLikeMe


    Export disorders for UBE2T gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UBE2T gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with UBE2T)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    2. Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells. (PubMed id 19887602)1, 2, 9 Ueki T....Katagiri T. (Cancer Res. 2009)
    3. Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T. (PubMed id 21722982)1, 2 Ramaekers C.H.... Wouters B.G. (Radiother. Oncol. 2011)
    4. Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway. (PubMed id 21775430)1, 2 Hodson C.... Walden H. (J. Biol. Chem. 2011)
    5. FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL. (PubMed id 19589784)1, 2 Longerich S.... Sung P. (J. Biol. Chem. 2009)
    6. Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI. (PubMed id 19111657)1, 2 Alpi A.F.... Patel K.J. (Mol. Cell 2008)
    7. UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination. (PubMed id 17938197)1, 2 Alpi A.... Patel K.J. (Mol. Cell. Biol. 2007)
    8. UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation. (PubMed id 16916645)1, 2 Machida Y.J.... Dutta A. (Mol. Cell 2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 29089 HGNC: 25009 AceView: HSPC150 Ensembl:ENSG00000077152 euGenes: HUgn29089
    ECgene: UBE2T Kegg: 29089 H-InvDB: UBE2T

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UBE2T Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UBE2T gene:
    Search GeneIP for patents involving UBE2T

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UBE2T
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for UBE2T (UBE2T)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBE2T   OriGene RNAi products in human, mouse, rat for UBE2T  
     OriGene qPCR primer pairs and template standards for UBE2T   OriGene Protein Over-expression Lysate for UBE2T  
     OriGene MassSpec something-or-other for UBE2T   OriGene clones in human, mouse for UBE2T  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBE2T   OriGene Purified Protein for UBE2T  
     OriGene ORF clones in mouse, rat for UBE2T   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBE2T   OriGene Custom Protein Services for UBE2T  

     
     
     Block miRNA regulation of human, mouse, rat UBE2T using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UBE2T
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2T Predesigned siRNA for gene silencing in human, mouse, rat UBE2T
     QuantiFast Probe-based Assays in human, mouse, rat UBE2T QuantiTect SYBR Green Assays in human, mouse, rat UBE2T
     PCR Arrays including human, mouse, rat UBE2T Search Chromatin IP Primers for UBE2T
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2T  GeneGlobe Interaction Network for UBE2T
     Regulatory tfbs in UBE2T promoter
     GenScript Custom Purified and Recombinant Proteins Services for UBE2T GenScript cDNA clones with any tag delivered in your preferred vector for UBE2T
     GenScript Custom Assay Services for UBE2T GenScript Custom overexpressing Cell Line Services for UBE2T
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for UBE2T 

     Search Tocris compounds for UBE2T
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for UBE2T
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UBE2T antibodies
     UBE2T proteins
     UBE2T lysates
     Antibodies for UBE2T
     See all of Abcam's Antibodies, Kits and Proteins for UBE2T
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UBE2T
     Proteins for UBE2T
     Antibodies for UBE2T
     ELISAs for UBE2T
     CLIAs for UBE2T



     Browse ESI BIO Cell Lines and PureStem Progenitors for UBE2T
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2T
     SwitchGear 3'UTR luciferase reporter plasmids for UBE2T
     SwitchGear Promoter luciferase reporter plasmids for UBE2T
     ThermoFisher Antibodies for UBE2T
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2T
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2T
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2T
     LSBio Antibodies in human, mouse, rat for UBE2T
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for UBE2T
      Search eBioscience for proteins for UBE2T
      Search eBioscience for elisas for UBE2T
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBE2T gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4