Aliases for UBE2T Gene
External Ids for UBE2T Gene
Previous GeneCards Identifiers for UBE2T Gene
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008]
GeneCards Summary for UBE2T Gene
UBE2T (Ubiquitin-Conjugating Enzyme E2T) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Remodeling of Adherens Junctions. GO annotations related to this gene include chromatin binding and ubiquitin protein ligase binding. An important paralog of this gene is UBE2N.
UniProtKB/Swiss-Prot for UBE2T Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair: acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer Lys-11-, Lys-27-, Lys-48- and Lys-63-linked polyubiquitination.