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Aliases for UBE2S Gene

Aliases for UBE2S Gene

  • Ubiquitin Conjugating Enzyme E2 S 2 3
  • Ubiquitin-Conjugating Enzyme E2-24 KDa 3 4
  • Ubiquitin-Conjugating Enzyme E2-24 KD 2 3
  • Ubiquitin-Conjugating Enzyme E2-EPF5 3 4
  • E2 Ubiquitin-Conjugating Enzyme S 3 4
  • Ubiquitin-Conjugating Enzyme E2S 2 3
  • Ubiquitin Conjugating Enzyme E2S 3 5
  • Ubiquitin Carrier Protein S 3 4
  • Ubiquitin-Protein Ligase S 3 4
  • E2-EPF 3 4
  • E2EPF 3 4
  • Ubiquitin Carrier Protein 2
  • Ubiquitin-Protein Ligase 2
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • E2-EPF5 3
  • EPF5 3

External Ids for UBE2S Gene

Previous GeneCards Identifiers for UBE2S Gene

  • GC19M060604
  • GC19M055912
  • GC19M052233

Summaries for UBE2S Gene

Entrez Gene Summary for UBE2S Gene

  • This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2S Gene

UBE2S (Ubiquitin Conjugating Enzyme E2 S) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Remodeling of Adherens Junctions. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2B.

UniProtKB/Swiss-Prot for UBE2S Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes Lys-11-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating Lys-11-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except Lys-48-linked polyubiquitination.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2S Gene

Genomics for UBE2S Gene

Regulatory Elements for UBE2S Gene

Enhancers for UBE2S Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2S on UCSC Golden Path with GeneCards custom track

Promoters for UBE2S Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2S on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2S Gene

Chromosome:
19
Start:
55,399,745 bp from pter
End:
55,408,146 bp from pter
Size:
8,402 bases
Orientation:
Minus strand

Genomic View for UBE2S Gene

Genes around UBE2S on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2S Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2S Gene

Proteins for UBE2S Gene

  • Protein details for UBE2S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16763-UBE2S_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 S
    Protein Accession:
    Q16763
    Secondary Accessions:
    • Q9BTC1

    Protein attributes for UBE2S Gene

    Size:
    222 amino acids
    Molecular mass:
    23845 Da
    Quaternary structure:
    • Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL.

    Three dimensional structures from OCA and Proteopedia for UBE2S Gene

neXtProt entry for UBE2S Gene

Proteomics data for UBE2S Gene at MOPED

Selected DME Specific Peptides for UBE2S Gene

Post-translational modifications for UBE2S Gene

  • Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.
  • Ubiquitination at Lys 18, Lys 68, Lys 100, Lys 117, and Lys 197
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2S Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UBE2S Gene

Gene Families for UBE2S Gene

Protein Domains for UBE2S Gene

Suggested Antigen Peptide Sequences for UBE2S Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16763

UniProtKB/Swiss-Prot:

UBE2S_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2S: view

Function for UBE2S Gene

Molecular function for UBE2S Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes Lys-11-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating Lys-11-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2S Gene

Gene Ontology (GO) - Molecular Function for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBE2S: view
genes like me logo Genes that share phenotypes with UBE2S: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2S Gene

Localization for UBE2S Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2S Gene COMPARTMENTS Subcellular localization image for UBE2S gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBE2S Gene

Pathways & Interactions for UBE2S Gene

genes like me logo Genes that share pathways with UBE2S: view

Pathways by source for UBE2S Gene

1 Cell Signaling Technology pathway for UBE2S Gene
1 BioSystems pathway for UBE2S Gene
1 KEGG pathway for UBE2S Gene
1 R&D Systems pathway for UBE2S Gene

UniProtKB/Swiss-Prot Q16763-UBE2S_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 1379239
GO:0008152 metabolic process IEA --
GO:0010994 free ubiquitin chain polymerization IDA 19822757
GO:0031145 anaphase-promoting complex-dependent catabolic process IDA 19820702
GO:0035519 protein K29-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2S: view

No data available for SIGNOR curated interactions for UBE2S Gene

Drugs & Compounds for UBE2S Gene

(3) Drugs for UBE2S Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2S Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2S: view

Transcripts for UBE2S Gene

Unigene Clusters for UBE2S Gene

Ubiquitin-conjugating enzyme E2S:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2S Gene

No ASD Table

Relevant External Links for UBE2S Gene

GeneLoc Exon Structure for
UBE2S
ECgene alternative splicing isoforms for
UBE2S

Expression for UBE2S Gene

mRNA expression in normal human tissues for UBE2S Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2S Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for UBE2S Gene

This gene is overexpressed in Breast (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2S Gene



SOURCE GeneReport for Unigene cluster for UBE2S Gene Hs.396393

genes like me logo Genes that share expression patterns with UBE2S: view

Protein tissue co-expression partners for UBE2S Gene

No data available for mRNA Expression by UniProt/SwissProt for UBE2S Gene

Orthologs for UBE2S Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2S Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2S 35
  • 88.29 (n)
  • 93.24 (a)
UBE2S 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2S 35
  • 88.14 (n)
  • 94.59 (a)
UBE2S 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2s 35
  • 86.19 (n)
  • 93.24 (a)
Ube2s 16
Ube2s 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2S 35
  • 99.1 (n)
  • 99.1 (a)
UBE2S 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2s 35
  • 87.24 (n)
  • 94.14 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2S 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2S 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6451 35
ube2s 35
  • 67.93 (n)
  • 80.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52831 35
zebrafish
(Danio rerio)
Actinopterygii Dr.17970 35
zgc:114060 35
  • 66.99 (n)
  • 71.5 (a)
UBE2S 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8188 35
  • 65.5 (n)
  • 63 (a)
CG8188 36
  • 61 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 36
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC22 35
  • 60 (n)
  • 65.16 (a)
soybean
(Glycine max)
eudicotyledons Gma.5718 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.761 35
rice
(Oryza sativa)
Liliopsida Os06g0660700 35
  • 57.03 (n)
  • 60.12 (a)
corn
(Zea mays)
Liliopsida Zm.6927 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.648 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.991 36
  • 60 (a)
OneToOne
Species with no ortholog for UBE2S:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2S Gene

ENSEMBL:
Gene Tree for UBE2S (if available)
TreeFam:
Gene Tree for UBE2S (if available)

Paralogs for UBE2S Gene

Paralogs for UBE2S Gene

Pseudogenes.org Pseudogenes for UBE2S Gene

genes like me logo Genes that share paralogs with UBE2S: view

Variants for UBE2S Gene

Sequence variations from dbSNP and Humsavar for UBE2S Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12978350 -- 55,407,199(+) AACCC(C/G)CCCCC intron-variant
rs8102125 -- 55,405,171(+) cgcca(C/T)tgcac intron-variant
rs71181761 -- 55,405,228(-) TTGGC(-/TT)TTTTT intron-variant
rs17849822 -- 55,404,408(+) TTGGG(G/T)GGGGA reference, synonymous-codon
rs1124917 -- 55,405,568(-) TTTTG(A/G)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2S Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv912473 CNV Loss 21882294

Variation tolerance for UBE2S Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.74% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBE2S Gene

Disorders for UBE2S Gene

Relevant External Links for UBE2S

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2S

No disorders were found for UBE2S Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2S Gene

Publications for UBE2S Gene

  1. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. (PMID: 1379239) Liu Z. … Giudice G.J. (J. Biol. Chem. 1992) 2 3 4 67
  2. Crystal Structure of a Ube2S-Ubiquitin Conjugate. (PMID: 26828794) Lorenz S. … Kuriyan J. (PLoS ONE 2016) 3
  3. Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. (PMID: 25490258) Yamaguchi M. … Schulman B.A. (J. Mol. Biol. 2015) 3
  4. Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. (PMID: 25527291) Wauer T. … Komander D. (EMBO J. 2015) 3
  5. RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex. (PMID: 25825779) Brown N.G. … Schulman B.A. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3

Products for UBE2S Gene

Sources for UBE2S Gene

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