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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2S Gene

protein-coding   GIFtS: 62
GCID: GC19M055912

Ubiquitin-Conjugating Enzyme E2S

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2S1 2     E2-EPF2 3
E2EPF2 3 5     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme E2-24 KD1 2     EPF52 5
Ubiquitin Carrier Protein S2 3     Ubiquitin Carrier Protein1
Ubiquitin-Conjugating Enzyme E2-24 KDa2 3     Ubiquitin-Protein Ligase1
Ubiquitin-Conjugating Enzyme E2-EPF52 3     E2-EPF52
Ubiquitin-Protein Ligase S2 3     Ubiquitin-Conjugating Enzyme E2 S2

External Ids:    HGNC: 178951   Entrez Gene: 273382   Ensembl: ENSG000001081067   OMIM: 6103095   UniProtKB: Q167633   

Export aliases for UBE2S gene to outside databases

Previous GC identifers: GC19M060604 GC19M052233


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2S Gene:
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol
ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of
ubiquitin carrier proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2S Gene: 
UBE2S (ubiquitin-conjugating enzyme E2S) is a protein-coding gene. Diseases associated with UBE2S include liddle syndrome, and pemphigus foliaceus, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is UBE2B.

UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome
(APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically
elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates,
enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by
elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether
UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent
degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all
7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2S gene promoter:
         Egr-3   SRF   RREB-1   SRF (504 AA)   MEF-2   Egr-4   MEF-2A   SEF-1 (1)   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2S promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2S

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2S


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.43

UBE2S Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2S gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055912:  view genomic region     (about GC identifiers)

Start:
55,912,650 bp from pter      End:
55,919,325 bp from pter
Size:
6,676 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 S  
Size: 222 amino acids; 23845 Da
Subunit: Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL
1 PDB 3D structure from and Proteopedia for UBE2S:
1ZDN (3D)    
Secondary accessions: Q9BTC1

Explore the universe of human proteins at neXtProt for UBE2S: NX_Q16763

Explore proteomics data for UBE2S at MOPED 

Post-translational modifications:

  • UniProtKB: Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16763

  • 2 DME Specific Peptides for UBE2S (Q16763)
     PPDGIKV  LLTIKCLLI 

    UBE2S Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2S Protein Expression
    REFSEQ proteins: NP_055316.2  
    ENSEMBL proteins: 
     ENSP00000264552   ENSP00000467409   ENSP00000466388  
    Reactome Protein details: Q16763
    Human Recombinant Protein Products for UBE2S: 
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    Novus Biologicals UBE2S Proteins
    Novus Biologicals UBE2S Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UBE2S
    Cloud-Clone Corp. Proteins for UBE2S 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005680anaphase-promoting complex IDA19822757

    UBE2S for ontologies           About GeneDecksing



    UBE2S Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q16763

    ProtoNet protein and cluster: Q16763

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2S for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2S_HUMAN, Q16763
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
    'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome
    (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically
    elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates,
    enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by
    elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether
    UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent
    degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all
    7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA19820702
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2S for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2S:
     Increased cell death in HCC-19  Increased gamma-H2AX phosphory  Increased release from monastr 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2S 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2S

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2S 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2S 

    miRNA
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    miRTarBase miRNAs that target UBE2S:
    hsa-mir-16 (MIRT001401)

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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2S:
    hsa-miR-3140-3p hsa-miR-1303 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidUBE2S 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2S About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3DNA Damage
    Cell Cycle / Checkpoint Control0.32
    4Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for UBE2S
        Cell Cycle / Checkpoint Control
    Protein Stability

    4        Reactome Pathways for UBE2S
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE2S):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
    Pathway: Protein modification; protein ubiquitination


    UBE2S for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2S

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/592 Interacting proteins for UBE2S (Q167632, 3 ENSP000002645524) via UniProtKB, MINT, STRING, and/or I2D (see all 592)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDC27P302602, 3MINT-7947479 I2D: score=1 
    ETV6P412122, 3MINT-7947479 I2D: score=1 
    CDC20Q128342, 3, ENSP000003084504MINT-7947479 I2D: score=1 STRING: ENSP00000308450
    RBCK1Q9BYM83, ENSP000003486324I2D: score=2 STRING: ENSP00000348632
    BIRC2Q134903, ENSP000002277584I2D: score=1 STRING: ENSP00000227758
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS1379239
    GO:0010458exit from mitosis IMP19822757
    GO:0010994free ubiquitin chain polymerization IDA19822757
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process IDA19820702
    GO:0035519protein K29-linked ubiquitination IDA--

    UBE2S for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2S

    4 HMDB Compounds for UBE2S    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2S

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2S gene: 
    NM_014501.2  

    Unigene Cluster for UBE2S:

    Ubiquitin-conjugating enzyme E2S
    Hs.396393  [show with all ESTs]
    Unigene Representative Sequence: BM479313
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264552(uc002qkx.1) ENST00000587845 ENST00000589978 ENST00000592570


    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidUBE2S 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB062397.1 BC004236.2 BC007554.1 BC065364.1 BC066948.1 M91670.1 

    21 DOTS entries:

    DT.99948312  DT.100793466  DT.451729  DT.121503213  DT.100793470  DT.120974316  DT.121503215  DT.100793463 
    DT.91762377  DT.95269991  DT.100793465  DT.121004353  DT.436623  DT.92412032  DT.99991873  DT.120974360 
    DT.121503180  DT.121503189  DT.121503229  DT.91653365  DT.91762375 

    24/385 AceView cDNA sequences (see all 385):

    AA355115 BG168034 BF940465 BM782899 BG179097 AI865061 BF718773 BQ926180 
    CR618880 BE253593 CR594048 BG114410 M91670 BU623599 AW104280 BG118308 
    BF793158 BE791805 BE262243 BM556321 BQ961491 BQ018306 BC047644 BG116513 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2S expression in normal human tissues (normalized intensities)      UBE2S embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGAGCG
    UBE2S Expression
    About this image


    UBE2S expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus

    See UBE2S Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2S

    SOURCE GeneReport for Unigene cluster: Hs.396393
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2S: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2S

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2S gene from 8/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2s1 , 5 ubiquitin-conjugating enzyme E2S1, 5 86.19(n)1
    93.24(a)1
      7 (2.78 cM)5
    778911  NM_133777.21  NP_598538.11 
     48081555 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2S6
    ubiquitin-conjugating enzyme E2S
    84(a)
    1 ↔ 1
    GL343279.1(1385129-1399145)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528312 hypothetical protein MGC52831 73.52(n)    BC041263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.179702 Transcribed sequence with moderate similarity to protein more 76.39(n)    AL722209.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81881 CG8188 66.17(n)
    63.5(a)
      32751  NM_001038763.1  NP_001033852.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD66
    Ubiquitin-conjugating enzyme (E2), involved in pos...
    28(a)
    1 → many
    VII(393986-394504)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC221 ubiquitin-conjugating enzyme E2 22 56.27(n)
    58.6(a)
      830390  NM_001085061.1  NP_001078530.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06607001 hypothetical protein 55.44(n)
    56.99(a)
      4341740  NM_001064806.1  NP_001058271.1 


    ENSEMBL Gene Tree for UBE2S (if available)
    TreeFam Gene Tree for UBE2S (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2S gene
    UBE2B2  UBE2A2  UBE2U2  
    18/23 SIMAP similar genes for UBE2S using alignment to 4 protein entries:     UBE2S_HUMAN (see all proteins) (see all similar genes):
    UBE2H    UBE2N    UBE2D3    UBE2E3    UBE2D2    UBE2D4
    UBE2C    UBE2I    UBE2K    UBE2D1    UBE2B    UBE2NL
    UBE2E1    UBE2M    UBE2G1    UBE2A    UBE2E2    UBE2T

    UBE2S for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBE2S
    PGOHUM00000237265


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/223 SNPs in UBE2S are shown (see all 223)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1464285131,2
    C--55912181(+) GGGAAC/TAGGCT 1 -- ds50010--------
    rs1152015891,2
    C,F--55912286(+) CGAGGC/TGAGCC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1132074111,2
    F--55912318(+) TGGCCG/ATCCTG 1 -- ds50012Minor allele frequency- A:0.03CSA WA 119
    rs116697321,2
    C,F,A,H--55912332(+) AGGAAT/CACCAC 1 -- ds500125Minor allele frequency- C:0.50NS EA NA WA CSA 2339
    rs104033611,2
    C,F,A,H--55912475(+) CTACCT/CCCACA 1 -- ds500119Minor allele frequency- C:0.13NS EA NA WA CSA 2332
    rs3696515531,2
    C--55912499(+) GACCC-/AAACCT 1 -- ds50010--------
    rs1407881221,2
    --55912544(+) TGCTGC/TAGTCC 1 -- ds50010--------
    rs1121319601,2
    C--55912594(+) CAAAC-/TCCCAG
    AGCCACAT
    GGCAC
    1 -- ds50011Minor allele frequency- TCCCAGAGCCACAT:0.00CSA 2
    rs1868646991,2
    --55912712(+) TCCCCA/GACCCC 1 -- ut310--------
    rs1917335961,2
    --55912714(+) CCCGAA/CCCCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2S (55912650 - 55919325 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for UBE2S:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912473CNV Loss21882294
    nsv912457CNV Loss21882294
    dgv4017n71CNV Loss21882294
    dgv4016n71CNV Loss21882294
    nsv912463CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610309    OMIM disorders: --

    9 diseases for UBE2S:    About MalaCards
    liddle syndrome    pemphigus foliaceus    pemphigus    angelman syndrome
    esophageal squamous cell carcinoma    renal cell carcinoma    esophagitis    squamous cell carcinoma
    parkinson's disease

    2 diseases from the University of Copenhagen DISEASES database for UBE2S:
    Angelman syndrome     Parkinson's disease

    UBE2S for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for UBE2S gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2S gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with UBE2S)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. (PubMed id 1379239)1, 2, 3 Liu Z.... Giudice G.J. (1992)
    2. Lys11-linked ubiquitin chains adopt compact conformat ions and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874)1, 2 Bremm A....Komander D. (2010)
    3. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PubMed id 19820702)1, 2 Garnett M.J.... Venkitaraman A.R. (2009)
    4. Identification of a physiological E2 module for the human anaphase- promoting complex. (PubMed id 19822757)1, 2 Williamson A....Rape M. (2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Electron microscopy structure of human APC/C(CDH1)-EMI 1 reveals multimodal mechanism of E3 ligase shutdown. (PubMed id 23708605)1 Frye J.J....Schulman B.A. (2013)
    7. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    8. Emi1 preferentially inhibits ubiquitin chain elongatio n by the anaphase-promoting complex. (PubMed id 23708001)1 Wang W. and Kirschner M.W. (2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. (PubMed id 22529100)1 Huang N.J.... Kornbluth S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27338 HGNC: 17895 AceView: UBE2S Ensembl:ENSG00000108106 euGenes: HUgn27338
    ECgene: UBE2S Kegg: 27338 H-InvDB: UBE2S

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2S Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2S Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2S gene:
    Search GeneIP for patents involving UBE2S

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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