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Aliases for UBE2S Gene

Aliases for UBE2S Gene

  • Ubiquitin Conjugating Enzyme E2 S 2 3 5
  • Ubiquitin-Conjugating Enzyme E2-24 KDa 3 4
  • Ubiquitin-Conjugating Enzyme E2-24 KD 2 3
  • Ubiquitin-Conjugating Enzyme E2-EPF5 3 4
  • E2 Ubiquitin-Conjugating Enzyme S 3 4
  • Ubiquitin Carrier Protein S 3 4
  • Ubiquitin-Protein Ligase S 3 4
  • E2-EPF 3 4
  • E2EPF 3 4
  • Ubiquitin-Conjugating Enzyme E2 S 3
  • Ubiquitin-Conjugating Enzyme E2S 2
  • Ubiquitin Conjugating Enzyme E2S 3
  • Ubiquitin Carrier Protein 2
  • Ubiquitin-Protein Ligase 2
  • EC 6.3.2.19 61
  • EC 2.3.2.23 4
  • E2-EPF5 3
  • EPF5 3

External Ids for UBE2S Gene

Previous GeneCards Identifiers for UBE2S Gene

  • GC19M060604
  • GC19M055912
  • GC19M052233

Summaries for UBE2S Gene

Entrez Gene Summary for UBE2S Gene

  • This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2S Gene

UBE2S (Ubiquitin Conjugating Enzyme E2 S) is a Protein Coding gene. Diseases associated with UBE2S include Parkinson Disease 15, Autosomal Recessive. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2A.

UniProtKB/Swiss-Prot for UBE2S Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes Lys-11-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating Lys-11-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except Lys-48-linked polyubiquitination.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2S Gene

Genomics for UBE2S Gene

Regulatory Elements for UBE2S Gene

Enhancers for UBE2S Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G055337 1.8 FANTOM5 ENCODE dbSUPER 11.2 +68.3 68319 4.0 MLX CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 NFYC LENG8-AS1 ENSG00000235681 U2AF2 FAM71E2 KMT5C PPP6R1 ZNF628 TMEM238 IL11 TMEM190
GH19G055246 1.7 Ensembl ENCODE dbSUPER 11 +154.3 154288 14.5 MLX CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC HSPBP1 TMEM86B NAT14 FIZ1 PPP6R1 BRSK1 RPL28 TMEM238 SYT5 UBE2S
GH19G055291 1.1 Ensembl ENCODE 11.3 +116.1 116113 1.0 HDAC1 ELF3 TBP PKNOX1 FOXA2 ARNT ARID4B SIN3A RAD21 RFX5 ZNF581 U2AF2 ENSG00000267523 ENSG00000235681 ENSG00000267265 LENG8-AS1 ZNF628 PPP6R1 TMEM238 RPL28
GH19G055300 0.9 ENCODE 11.6 +106.3 106300 2.0 HDAC1 TBP RB1 SIN3A ZBTB7B RAD21 RFX5 GLIS2 EGR1 ZNF143 TMEM86B TMEM150B KMT5C HSPBP1 PPP6R1 RPL28 TMEM238 UBE2S TMEM190 ZNF628
GH19G055172 1 ENCODE 10.4 +234.5 234490 2.1 PKNOX1 FOXA2 ARNT MLX AGO1 SIN3A ARID4B DMAP1 GLI4 YY1 SYT5 TNNT1 TMEM86B BRSK1 UBE2S RDH13 EPS8L1 ENSG00000239137
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2S on UCSC Golden Path with GeneCards custom track

Promoters for UBE2S Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111652 346 1601 HDGF PKNOX1 CREB3L1 ARNT AGO1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1

Genomic Location for UBE2S Gene

Chromosome:
19
Start:
55,399,745 bp from pter
End:
55,408,146 bp from pter
Size:
8,402 bases
Orientation:
Minus strand

Genomic View for UBE2S Gene

Genes around UBE2S on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2S Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2S Gene

Proteins for UBE2S Gene

  • Protein details for UBE2S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16763-UBE2S_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 S
    Protein Accession:
    Q16763
    Secondary Accessions:
    • Q9BTC1

    Protein attributes for UBE2S Gene

    Size:
    222 amino acids
    Molecular mass:
    23845 Da
    Quaternary structure:
    • Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL.

    Three dimensional structures from OCA and Proteopedia for UBE2S Gene

neXtProt entry for UBE2S Gene

Selected DME Specific Peptides for UBE2S Gene

Q16763:
  • LLTIKCLLI
  • PPDGIKV

Post-translational modifications for UBE2S Gene

  • Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.
  • Ubiquitination at Lys18, posLast=6868, Lys100, isoforms=117, and Lys197
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2S Gene

Domains & Families for UBE2S Gene

Gene Families for UBE2S Gene

Suggested Antigen Peptide Sequences for UBE2S Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16763

UniProtKB/Swiss-Prot:

UBE2S_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2S: view

Function for UBE2S Gene

Molecular function for UBE2S Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes Lys-11-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating Lys-11-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2S Gene

Gene Ontology (GO) - Molecular Function for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19820702
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2S: view
genes like me logo Genes that share phenotypes with UBE2S: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2S

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2S Gene

Localization for UBE2S Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2S gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 3
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005680 anaphase-promoting complex IDA 19822757
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2S: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2S Gene

Pathways & Interactions for UBE2S Gene

genes like me logo Genes that share pathways with UBE2S: view

Pathways by source for UBE2S Gene

1 KEGG pathway for UBE2S Gene
1 R&D Systems pathway for UBE2S Gene

UniProtKB/Swiss-Prot Q16763-UBE2S_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 1379239
GO:0007049 cell cycle IEA --
GO:0010458 exit from mitosis IMP 19822757
GO:0010994 free ubiquitin chain polymerization IDA 19822757
GO:0016567 protein ubiquitination TAS --
genes like me logo Genes that share ontologies with UBE2S: view

No data available for SIGNOR curated interactions for UBE2S Gene

Drugs & Compounds for UBE2S Gene

(3) Drugs for UBE2S Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2S Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2S: view

Transcripts for UBE2S Gene

Unigene Clusters for UBE2S Gene

Ubiquitin-conjugating enzyme E2S:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2S

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2S Gene

No ASD Table

Relevant External Links for UBE2S Gene

GeneLoc Exon Structure for
UBE2S
ECgene alternative splicing isoforms for
UBE2S

Expression for UBE2S Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2S Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2S Gene

This gene is overexpressed in Testis (x6.7).

Protein differential expression in normal tissues from HIPED for UBE2S Gene

This gene is overexpressed in Breast (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2S Gene



Protein tissue co-expression partners for UBE2S Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2S Gene:

UBE2S

SOURCE GeneReport for Unigene cluster for UBE2S Gene:

Hs.396393

Evidence on tissue expression from TISSUES for UBE2S Gene

  • Skin(4.5)
  • Intestine(4.3)
  • Nervous system(3.4)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with UBE2S: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2S Gene

Orthologs for UBE2S Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2S Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2S 34 35
  • 99.1 (n)
cow
(Bos Taurus)
Mammalia UBE2S 34 35
  • 88.29 (n)
dog
(Canis familiaris)
Mammalia UBE2S 34 35
  • 88.14 (n)
rat
(Rattus norvegicus)
Mammalia Ube2s 34
  • 87.24 (n)
mouse
(Mus musculus)
Mammalia Ube2s 34 16 35
  • 86.19 (n)
oppossum
(Monodelphis domestica)
Mammalia UBE2S 35
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2S 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2s 34
  • 67.93 (n)
Str.6451 34
African clawed frog
(Xenopus laevis)
Amphibia MGC52831 34
zebrafish
(Danio rerio)
Actinopterygii UBE2S 35
  • 69 (a)
OneToOne
zgc:114060 34
  • 66.99 (n)
Dr.17970 34
fruit fly
(Drosophila melanogaster)
Insecta CG8188 34 35
  • 65.5 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 35
  • 30 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC22 34
  • 60 (n)
soybean
(Glycine max)
eudicotyledons Gma.5718 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.761 34
rice
(Oryza sativa)
Liliopsida Os06g0660700 34
  • 57.03 (n)
corn
(Zea mays)
Liliopsida Zm.6927 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.991 35
  • 60 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.648 34
Species where no ortholog for UBE2S was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2S Gene

ENSEMBL:
Gene Tree for UBE2S (if available)
TreeFam:
Gene Tree for UBE2S (if available)

Paralogs for UBE2S Gene

Paralogs for UBE2S Gene

Pseudogenes.org Pseudogenes for UBE2S Gene

genes like me logo Genes that share paralogs with UBE2S: view

Variants for UBE2S Gene

Sequence variations from dbSNP and Humsavar for UBE2S Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000045314 -- 55,402,794(+) GGAGG(C/T)GGTAC intron-variant
rs1000271401 -- 55,408,068(+) GACGC(A/G)GCCGC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000480276 -- 55,407,202(+) CCCCC(C/G/T)CCCAA intron-variant, upstream-variant-2KB
rs1000601719 -- 55,407,059(+) CAGTG(G/T)CCCCA intron-variant, upstream-variant-2KB
rs1001266663 -- 55,403,558(+) AAGAA(A/C)GAGCT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UBE2S Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366

Variation tolerance for UBE2S Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2S Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2S

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2S Gene

Disorders for UBE2S Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBE2S Gene - From: DISEASES

Disorder Aliases PubMed IDs
parkinson disease 15, autosomal recessive
  • autosomal recessive early-onset parkinson disease 15
- elite association - COSMIC cancer census association via MalaCards
Search UBE2S in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBE2S

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2S
genes like me logo Genes that share disorders with UBE2S: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2S Gene

Publications for UBE2S Gene

  1. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. (PMID: 1379239) Liu Z. … Giudice G.J. (J. Biol. Chem. 1992) 2 3 4 64
  2. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4 64
  3. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PMID: 20622874) Bremm A. … Komander D. (Nat. Struct. Mol. Biol. 2010) 3 4 64
  4. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PMID: 19820702) Garnett M.J. … Venkitaraman A.R. (Nat. Cell Biol. 2009) 3 4 64
  5. Identification of a physiological E2 module for the human anaphase- promoting complex. (PMID: 19822757) Williamson A. … Rape M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4 64

Products for UBE2S Gene

  • Addgene plasmids for UBE2S

Sources for UBE2S Gene

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