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Aliases for UBE2S Gene

Aliases for UBE2S Gene

  • Ubiquitin-Conjugating Enzyme E2S 2 3
  • E2EPF 3 4 6
  • Ubiquitin-Conjugating Enzyme E2-24 KDa 3 4
  • Ubiquitin-Conjugating Enzyme E2-24 KD 2 3
  • Ubiquitin-Conjugating Enzyme E2-EPF5 3 4
  • Ubiquitin Carrier Protein S 3 4
  • Ubiquitin-Protein Ligase S 3 4
  • EC 6.3.2.19 4 64
  • E2-EPF 3 4
  • EPF5 3 6
  • Ubiquitin-Conjugating Enzyme E2 S 3
  • Ubiquitin Carrier Protein 2
  • Ubiquitin-Protein Ligase 2
  • E2-EPF5 3

External Ids for UBE2S Gene

Summaries for UBE2S Gene

Entrez Gene Summary for UBE2S Gene

  • This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2S Gene

UBE2S (Ubiquitin-Conjugating Enzyme E2S) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle / Checkpoint Control. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2B.

UniProtKB/Swiss-Prot for UBE2S Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes Lys-11-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating Lys-11-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except Lys-48-linked polyubiquitination.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2S Gene

Genomics for UBE2S Gene

Genomic Location for UBE2S Gene

Start:
55,399,745 bp from pter
End:
55,407,957 bp from pter
Size:
8,213 bases
Orientation:
Minus strand

Genomic View for UBE2S Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2S Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2S Gene

Regulatory Elements for UBE2S Gene

Proteins for UBE2S Gene

  • Protein details for UBE2S Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16763-UBE2S_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 S
    Protein Accession:
    Q16763
    Secondary Accessions:
    • Q9BTC1

    Protein attributes for UBE2S Gene

    Size:
    222 amino acids
    Molecular mass:
    23845 Da
    Quaternary structure:
    • Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL.

    Three dimensional structures from OCA and Proteopedia for UBE2S Gene

neXtProt entry for UBE2S Gene

Proteomics data for UBE2S Gene at MOPED

Selected DME Specific Peptides for UBE2S Gene

Post-translational modifications for UBE2S Gene

  • Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys18, Lys68, Lys100, Lys117, and Lys197

Other Protein References for UBE2S Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UBE2S Gene

Gene Families for UBE2S Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2S Gene

UniProtKB/Swiss-Prot:

UBE2S_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • Q16763
genes like me logo Genes that share domains with UBE2S: view

Function for UBE2S Gene

Molecular function for UBE2S Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes Lys-11-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating Lys-11-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2S Gene

Gene Ontology (GO) - Molecular Function for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 19820702
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity IBA --
genes like me logo Genes that share ontologies with UBE2S: view
genes like me logo Genes that share phenotypes with UBE2S: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2S Gene

Localization for UBE2S Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2S Gene COMPARTMENTS Subcellular localization image for UBE2S gene
Compartment Confidence
nucleus 5
cytosol 3
endoplasmic reticulum 2
cytoskeleton 1
lysosome 1
mitochondrion 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005680 anaphase-promoting complex IDA 19822757
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBE2S: view

Pathways for UBE2S Gene

genes like me logo Genes that share pathways with UBE2S: view

UniProtKB/Swiss-Prot Q16763-UBE2S_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2S Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 1379239
GO:0008152 metabolic process --
GO:0010458 exit from mitosis IMP 19822757
GO:0010994 free ubiquitin chain polymerization IDA 19822757
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process IDA 19820702
genes like me logo Genes that share ontologies with UBE2S: view

Compounds for UBE2S Gene

(4) HMDB Compounds for UBE2S Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2S: view

Transcripts for UBE2S Gene

Unigene Clusters for UBE2S Gene

Ubiquitin-conjugating enzyme E2S:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2S Gene

No ASD Table

Relevant External Links for UBE2S Gene

GeneLoc Exon Structure for
UBE2S
ECgene alternative splicing isoforms for
UBE2S

Expression for UBE2S Gene

mRNA expression in normal human tissues for UBE2S Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2S Gene

This gene is overexpressed in Testis (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2S Gene

SOURCE GeneReport for Unigene cluster for UBE2S Gene Hs.396393

genes like me logo Genes that share expressions with UBE2S: view

Orthologs for UBE2S Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2S Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2S 36
  • 99.1 (n)
  • 99.1 (a)
UBE2S 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2S 36
  • 88.29 (n)
  • 93.24 (a)
UBE2S 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2S 36
  • 88.14 (n)
  • 94.59 (a)
UBE2S 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2s 36
  • 86.19 (n)
  • 93.24 (a)
Ube2s 16
Ube2s 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2S 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2s 36
  • 87.24 (n)
  • 94.14 (a)
lizard
(Anolis carolinensis)
Reptilia UBE2S 37
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC52831 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6451 36
ube2s 36
  • 67.93 (n)
  • 80.09 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.17970 36
UBE2S 37
  • 69 (a)
OneToOne
zgc:114060 36
  • 66.99 (n)
  • 71.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8188 36
  • 65.5 (n)
  • 63 (a)
CG8188 37
  • 61 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 37
  • 30 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.761 36
soybean
(Glycine max)
eudicotyledons Gma.5718 36
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC22 36
  • 60 (n)
  • 65.16 (a)
corn
(Zea mays)
Liliopsida Zm.6927 36
rice
(Oryza sativa)
Liliopsida Os06g0660700 36
  • 57.03 (n)
  • 60.12 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.648 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.991 37
  • 60 (a)
OneToOne
Species with no ortholog for UBE2S:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2S Gene

ENSEMBL:
Gene Tree for UBE2S (if available)
TreeFam:
Gene Tree for UBE2S (if available)

Paralogs for UBE2S Gene

Paralogs for UBE2S Gene

Pseudogenes.org Pseudogenes for UBE2S Gene

genes like me logo Genes that share paralogs with UBE2S: view

Variants for UBE2S Gene

Sequence variations from dbSNP and Humsavar for UBE2S Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1124917 -- 55,405,568(-) TTTTG(A/G)GGGAG intron-variant
rs1551563 -- 55,408,966(+) CCCTC(C/T)CGGTG upstream-variant-2KB
rs7250012 -- 55,408,570(+) CTCCG(G/T)GTGTG upstream-variant-2KB
rs8102125 -- 55,405,171(+) cgcca(C/T)tgcac intron-variant
rs10408448 -- 55,408,780(+) GAAAT(G/T)GACAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UBE2S Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv912473 CNV Loss 21882294

Relevant External Links for UBE2S Gene

HapMap Linkage Disequilibrium report
UBE2S

Disorders for UBE2S Gene

(2) University of Copenhagen DISEASES for UBE2S Gene

genes like me logo Genes that share disorders with UBE2S: view

No data available for UniProtKB/Swiss-Prot for UBE2S Gene

Publications for UBE2S Gene

  1. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. (PMID: 1379239) Liu Z. … Giudice G.J. (J. Biol. Chem. 1992) 2 3 4
  2. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PMID: 19820702) Garnett M.J. … Venkitaraman A.R. (Nat. Cell Biol. 2009) 3 4
  3. Identification of a physiological E2 module for the human anaphase- promoting complex. (PMID: 19822757) Williamson A. … Rape M. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 4
  4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UBE2S Gene

  • Addgene plasmids for UBE2S

Sources for UBE2S Gene

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