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UBE2S Gene

protein-coding   GIFtS: 63
GCID: GC19M055912

Ubiquitin-Conjugating Enzyme E2S

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2S1 2     E2-EPF2 3
E2EPF2 3 5     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme E2-24 KD1 2     EPF52 5
Ubiquitin Carrier Protein S2 3     Ubiquitin Carrier Protein1
Ubiquitin-Conjugating Enzyme E2-24 KDa2 3     Ubiquitin-Protein Ligase1
Ubiquitin-Conjugating Enzyme E2-EPF52 3     E2-EPF52
Ubiquitin-Protein Ligase S2 3     Ubiquitin-Conjugating Enzyme E2 S2

External Ids:    HGNC: 178951   Entrez Gene: 273382   Ensembl: ENSG000001081067   OMIM: 6103095   UniProtKB: Q167633   

Export aliases for UBE2S gene to outside databases

Previous GC identifers: GC19M060604 GC19M052233


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2S Gene:
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol
ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of
ubiquitin carrier proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2S Gene:
UBE2S (ubiquitin-conjugating enzyme E2S) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2B.

UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome
(APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically
elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates,
enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by
elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether
UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent
degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all
7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2S gene promoter:
         Egr-3   SRF   RREB-1   SRF (504 AA)   MEF-2   Egr-4   MEF-2A   SEF-1 (1)   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2S promoter sequence
   Search Chromatin IP Primers for UBE2S

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2S


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.43

UBE2S Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2S gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M055912:  view genomic region     (about GC identifiers)

Start:
55,912,650 bp from pter      End:
55,919,325 bp from pter
Size:
6,676 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 S  
Size: 222 amino acids; 23845 Da
Subunit: Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL
1 PDB 3D structure from and Proteopedia for UBE2S:
1ZDN (3D)    
Secondary accessions: Q9BTC1

Explore the universe of human proteins at neXtProt for UBE2S: NX_Q16763

Explore proteomics data for UBE2S at MOPED

Post-translational modifications: 

  • Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome1
  • Ubiquitination2 at Lys18, Lys68, Lys100, Lys117, Lys197
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for UBE2S (Q16763)
     PPDGIKV  LLTIKCLLI 


    See UBE2S Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055316.2  
    ENSEMBL proteins: 
     ENSP00000264552   ENSP00000467409   ENSP00000466388  
    Reactome Protein details: Q16763

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q16763

    ProtoNet protein and cluster: Q16763

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2S           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2S_HUMAN, Q16763
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
    'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome
    (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically
    elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates,
    enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by
    elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether
    UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent
    degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all
    7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA19820702
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with UBE2S           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2S:
     Increased cell death in HCC-19  Increased gamma-H2AX phosphory  Increased release from monastr 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UBE2S

    miRNA
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    miRTarBase miRNAs that target UBE2S:
    hsa-mir-17-5p (MIRT050848), hsa-mir-16-5p (MIRT001401), hsa-mir-34a-5p (MIRT025286), hsa-mir-324-5p (MIRT043221), hsa-mir-149-5p (MIRT045572), hsa-mir-484 (MIRT042126)

    Block miRNA regulation of human, mouse, rat UBE2S using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate UBE2S:
    hsa-miR-3140-3p hsa-miR-1303 hsa-miR-32*
    SwitchGear 3'UTR luciferase reporter plasmidUBE2S 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE2S

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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2S
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endoplasmic reticulum2
    cytoskeleton1
    lysosome1
    mitochondrion1
    plasma membrane1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005680anaphase-promoting complex IDA19822757

    Find genes that share ontologies with UBE2S           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2S About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Cell Cycle / Checkpoint Control
    Cell Cycle / Checkpoint Control0.32
    3Protein Stability
    Protein Stability


    Find genes that share SuperPaths with UBE2S           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2S
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for UBE2S
        Cell Cycle / Checkpoint Control
    Protein Stability


    1 Reactome Pathway for UBE2S
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for UBE2S):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2S: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2S

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2S (Q167632, 3 ENSP000002645524) via UniProtKB, MINT, STRING, and/or I2D (see all 622)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETV6P412122, 3, ENSP000002664274MINT-7947479 I2D: score=1 STRING: ENSP00000266427
    CDC27P302602, 3MINT-7947479 I2D: score=1 
    CDC20Q128342, 3, ENSP000003084504MINT-7947479 I2D: score=1 STRING: ENSP00000308450
    RBCK1Q9BYM83, ENSP000003486324I2D: score=2 STRING: ENSP00000348632
    BIRC2Q134903, ENSP000002277584I2D: score=1 STRING: ENSP00000227758
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS1379239
    GO:0010458exit from mitosis IMP19822757
    GO:0010994free ubiquitin chain polymerization IDA19822757
    GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process IDA19820702
    GO:0035519protein K29-linked ubiquitination IDA--

    Find genes that share ontologies with UBE2S           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2S

    4 HMDB Compounds for UBE2S    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2S gene: 
    NM_014501.2  

    Unigene Cluster for UBE2S:

    Ubiquitin-conjugating enzyme E2S
    Hs.396393  [show with all ESTs]
    Unigene Representative Sequence: BM479313
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264552(uc002qkx.1) ENST00000587845 ENST00000589978 ENST00000592570

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    SwitchGear 3'UTR luciferase reporter plasmidUBE2S 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat UBE2S
      QuantiFast Probe-based Assays in human, mouse, rat UBE2S

    Additional mRNA sequence: 

    AB062397.1 BC004236.2 BC007554.1 BC065364.1 BC066948.1 M91670.1 

    21 DOTS entries:

    DT.99948312  DT.100793466  DT.451729  DT.121503213  DT.100793470  DT.120974316  DT.121503215  DT.100793463 
    DT.91762377  DT.95269991  DT.100793465  DT.121004353  DT.436623  DT.92412032  DT.99991873  DT.120974360 
    DT.121503180  DT.121503189  DT.121503229  DT.91653365  DT.91762375 

    Selected AceView cDNA sequences (see all 385):

    AA355115 CR594048 T19021 BM782899 BG283238 BG118308 AW104280 CR618880 
    BI093302 CR626565 BU623599 T29587 BE253593 BE791805 BE269633 BG114410 
    BF940465 BG179097 BF793158 NM_014501 M91670 BE887139 BU739658 BF718773 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2S expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGAGCG
    UBE2S Expression
    About this image


    UBE2S expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
    UBE2S Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2S Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.396393
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2S: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2S

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2S gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2s1 , 5 ubiquitin-conjugating enzyme E2S1, 5 86.19(n)1
    93.24(a)1
      7 (2.78 cM)5
    778911  NM_133777.21  NP_598538.11 
     48081555 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2S6
    ubiquitin-conjugating enzyme E2S
    84(a)
    1 ↔ 1
    GL343279.1(1385129-1399145)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528312 hypothetical protein MGC52831 73.52(n)    BC041263.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.179702 Transcribed sequence with moderate similarity to protein more 76.39(n)    AL722209.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG81881 CG8188 65.5(n)
    63(a)
      32751  NM_001038763.1  NP_001033852.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD66
    Ubiquitin-conjugating enzyme (E2), involved in pos...
    30(a)
    1 → many
    VII(393986-394504) YGL058W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC221 UBC22 60(n)
    65.16(a)
      830390  NM_120590.2  NP_568148.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g06607001 Os06g0660700 57.03(n)
    60.12(a)
      4341740  NM_001064806.1  NP_001058271.1 


    ENSEMBL Gene Tree for UBE2S (if available)
    TreeFam Gene Tree for UBE2S (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2S gene
    UBE2B2  UBE2A2  UBE2U2  
    Selected SIMAP similar genes for UBE2S using alignment to 4 protein entries:     UBE2S_HUMAN (see all proteins) (see all similar genes):
    UBE2H    UBE2N    UBE2D3    UBE2E3    UBE2D2    UBE2D4
    UBE2C    UBE2I    UBE2E1    UBE2K    UBE2D1    UBE2B
    UBE2NL    UBE2M    UBE2G1    UBE2A    UBE2E2    UBE2T

    Find genes that share paralogs with UBE2S           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UBE2S
    PGOHUM00000237265


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2S (see all 223)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1464285131,2
    C--55912181(+) GGGAAC/TAGGCT 1 -- ds50010--------
    rs1152015891,2
    C,F--55912286(+) CGAGGC/TGAGCC 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1132074111,2
    F--55912318(+) TGGCCG/ATCCTG 1 -- ds50012Minor allele frequency- A:0.03CSA WA 119
    rs116697321,2
    C,F,A,H--55912332(+) AGGAAT/CACCAC 1 -- ds500125Minor allele frequency- C:0.50NS EA NA WA CSA 2339
    rs104033611,2
    C,F,A,H--55912475(+) CTACCT/CCCACA 1 -- ds500119Minor allele frequency- C:0.13NS EA NA WA CSA 2332
    rs3696515531,2
    C--55912499(+) GACCC-/AAACCT 1 -- ds50010--------
    rs1407881221,2
    --55912544(+) TGCTGC/TAGTCC 1 -- ds50010--------
    rs1121319601,2
    C--55912594(+) CAAAC-/TCCCAG
    AGCCACAT
    GGCAC
    1 -- ds50011Minor allele frequency- TCCCAGAGCCACAT:0.00CSA 2
    rs1868646991,2
    --55912712(+) TCCCCA/GACCCC 1 -- ut310--------
    rs1917335961,2
    --55912714(+) CCCGAA/CCCCAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2S (55912650 - 55919325 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for UBE2S:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912473CNV Loss21882294
    nsv912457CNV Loss21882294
    dgv4017n71CNV Loss21882294
    dgv4016n71CNV Loss21882294
    nsv912463CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2S
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2S

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610309    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for UBE2S:
    Angelman syndrome     Parkinson's disease

    Find genes that share disorders with UBE2S           About GenesLikeMe


    Export disorders for UBE2S gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2S gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with UBE2S)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a novel human ubiquitin carrier protein. An antigenic domain specifically recognized by endemic pemphigus foliaceus autoantibodies is encoded in a secondary reading frame of this human epidermal transcript. (PubMed id 1379239)1, 2, 3 Liu Z.... Giudice G.J. (J. Biol. Chem. 1992)
    2. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874)1, 2 Bremm A.... Komander D. (Nat. Struct. Mol. Biol. 2010)
    3. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PubMed id 19820702)1, 2 Garnett M.J.... Venkitaraman A.R. (Nat. Cell Biol. 2009)
    4. Identification of a physiological E2 module for the human anaphase- promoting complex. (PubMed id 19822757)1, 2 Williamson A....Rape M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown. (PubMed id 23708605)1 Frye J.J....Schulman B.A. (amp 2013)
    7. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    8. Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. (PubMed id 23708001)1 Wang W. and Kirschner M.W. (Nat. Cell Biol. 2013)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    10. The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. (PubMed id 22529100)1 Huang N.J.... Kornbluth S. (J. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27338 HGNC: 17895 AceView: UBE2S Ensembl:ENSG00000108106 euGenes: HUgn27338
    ECgene: UBE2S Kegg: 27338 H-InvDB: UBE2S

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2S Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2S Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2S gene:
    Search GeneIP for patents involving UBE2S

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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