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Aliases & Descriptions for UBE2S
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| E2-EPF 1, 2 | | E2-EPF5 3 | | E2EPF 2, 3, 5 | | EC 6.3.2.19 3 | | EPF5 2, 5 |
| | | Descriptions |
|---|
| Ubiquitin carrier protein S 2, 3 | | Ubiquitin-conjugating enzyme E2-24 kDa 3 | | Ubiquitin-protein ligase S 2, 3 | | ubiquitin-conjugating enzyme E2-24 kD 2 | | ubiquitin-conjugating enzyme E2S 2 |
|
| | Search outside databases for aliases for UBE2S gene |
Summaries for UBE2S(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for UBE2S: This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq] UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity) |
Genomic Location for UBE2S
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBE2S gene 
Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.43UBE2S Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M060604:
(about GC identifiers)
Start:
|
60,604,462 bp from pter |
End:
|
60,611,137 bp from pter |
Size:
|
6,676 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for UBE2S
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 S Size: 222 amino acids; 23845 Da
PDB structures from and Proteopedia :1ZDN (3D)
 
Secondary accessions: Q9BTC1Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055316.2
ENSEMBL proteins: ENSP00000264552
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: UBE2S 
Antibodies for UBE2S: Assays for UBE2S: | Protein
Domains/ Families for UBE2S(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q16763
ProtoNet protein and cluster: Q16763 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763Similarity: Belongs to the ubiquitin-conjugating enzyme family | Gene Function for UBE2S
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014501
Applied Biosystems Silencer® siRNAs for UBE2S
Sigma-Aldrich siRNA and siRNA Panels for UBE2S  Sigma-Aldrich shRNA Panels and shRNA for UBE2S  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014501                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014501                                  untagged cDNA clones in CMV expression vector (see all 2): BC066948 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: BC066948
UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- | | GO:0016874 | ligase activity |
IEA | -- | About this table | Pathways & Interactions for UBE2S
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 3 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2S (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763Pathway: Protein modification; protein ubiquitination Gene Network CentralTM Interacting Genes and Proteins Network for UBE2S 
2 Interacting proteins for UBE2S (ENSP000002645523) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for UBE2S(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBE2S
|
Transcripts for UBE2S(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014501
Sigma-Aldrich siRNA and siRNA Panels for UBE2S  Sigma-Aldrich shRNA Panels and shRNA for UBE2S  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014501 REFSEQ mRNAs for UBE2S gene: NM_014501.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014501               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014501                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014501                                  untagged cDNA clones in CMV expression vector (see all 2): BC066948  Additional cDNA sequence: AB062397.1 BC004236.2 BC007554.1 BC065364.1 BC066948.1 CR594048.1 CR596308.1 CR611408.1 CR618880.1 CR622781.1 CR626565.1 M91670.1 21 DOTS entries: DT.99948312 DT.100793466 DT.451729 DT.121503213 DT.100793470 DT.120974316 DT.121503215 DT.100793463 DT.95269991 DT.100793465 DT.121004353 DT.436623 DT.91762377 DT.92412032 DT.120974360 DT.121503180 DT.121503189 DT.99991873 DT.121503229 DT.91653365 DT.91762375 24/385 AceView cDNA sequences (see all 385
):BE791805 BQ961491 BQ926180 BI093302 CR618880 BM782899 CR594048 BU739658 BF035772 BG116513 AA355115 BI856833 BF718773 BE382478 AI865061 BG179097 M91670 BE262243 CR622781 BE253593 T19021 BM794482 BG118308 BG250687
highest scoring ESTs for UBE2S:M91670 AB062397 AL524393 AL524942 AW409921 BC004236 BC007554 BC065364 BE252503 BE253593 Unigene Cluster for UBE2S: Ubiquitin-conjugating enzyme E2S Hs.396393 [show with all ESTs]Unigene Representative Sequence: BM479313
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000264552
|
Expression for UBE2S
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBE2S expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBE2S
1 / 2 / 3 5 probe-sets matching UBE2S gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTGGCGAGCG
SOURCE GeneReport for Unigene cluster: Hs.396393
Expression variation in blood from EXPOLDB for UBE2S |
Orthologs for UBE2S
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2S gene from 5/15 species (see all 15
)
About this table Species with no ortholog for UBE2S
ENSEMBL Gene Tree for UBE2S | Paralogs for UBE2S(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBE2S gene
- UBE2L62 UBE2I2 UBE2L32
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for UBE2S(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBE2S (up to first 250kb)
|
Disorders & Mutations for UBE2S
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610309
|
Medical News for UBE2S(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBE2S (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for UBE2S gene: |
Search for UBE2S
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBE2S
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBE2S
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2S(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBE2S(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBE2S:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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