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UBE2S Gene

protein-coding   GIFtS: 56

GC19M060604
ubiquitin-conjugating enzyme E2S
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
E2-EPF 1, 2
E2-EPF5 3
E2EPF 2, 3, 5
EC 6.3.2.19 3
EPF5 2, 5
Descriptions
Ubiquitin carrier protein S 2, 3
Ubiquitin-conjugating enzyme E2-24 kDa 3
Ubiquitin-protein ligase S 2, 3
ubiquitin-conjugating enzyme E2-24 kD 2
ubiquitin-conjugating enzyme E2S 2
External Ids
HGNC: 178951
Entrez Gene: 273382
UniProtKB: Q167633
Ensembl: ENSG000001081067
Search outside databases for aliases for UBE2S gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2S:
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able
to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a
characteristic property of ubiquitin carrier proteins. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the UBE2S gene  

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.43

UBE2S Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M060604:     (about GC identifiers)

Start:
60,604,462 bp from pter
End:
60,611,137 bp from pter
Size:
6,676 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 S  
Size: 222 amino acids; 23845 Da
PDB structures from and Proteopedia :
1ZDN (3D)    
Secondary accessions: Q9BTC1

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_055316.2  

    ENSEMBL proteins: 
    ENSP00000264552 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (E2 EPF)
    Human Recombinant Proteins from Abnova (UBE2S)
                  OriGene Purified Recombinant Human Protein: UBE2S 


    Antibodies for UBE2S: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for UBE2S
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (E2 EPF), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (UBE2S)
    Novus Biologicals Antibodies for UBE2S

    Assays for UBE2S: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugat/RWD-like


       GeneDecks  UBE2S for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q16763

    ProtoNet protein and cluster: Q16763

    1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
    Similarity: Belongs to the ubiquitin-conjugating enzyme family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBE2S)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (UBE2S)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014501

                  Applied Biosystems Silencer® siRNAs for UBE2S

                  Sigma-Aldrich siRNA and siRNA Panels for UBE2S  
                         Sigma-Aldrich shRNA Panels and shRNA for UBE2S  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for UBE2S
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014501
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014501
                                     untagged cDNA clones in CMV expression vector (see all 2): BC066948 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: BC066948

    UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein
    N-ubiquityllysine
    Enzyme Number (IUBMB): EC 6.3.2.19 

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842 ubiquitin-protein ligase activity IEA--
    GO:0016874 ligase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    3 Sigma-Aldrich "Your Favorite Gene" Pathways for  UBE2S  (Your Favorite Gene powered by Ingenuity) 
     Huntington's Disease Signaling
     Hypoxia Signaling in the Cardiovascular System
     Protein Ubiquitination Pathway

       GeneDecks  UBE2S for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for UBE2S):
     hsa04120 Ubiquitin mediated proteolysis

       GeneDecks  UBE2S for the pathways selected above  
    About GeneDecksing
    UniProtKB/Swiss-Prot: UBE2S_HUMAN, Q16763
    Pathway: Protein modification; protein ubiquitination

     Gene Network CentralTM Interacting Genes and Proteins Network for  UBE2S 


    2 Interacting proteins for UBE2S (ENSP000002645523) via UniProtKB, MINT, and/or STRING

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448183STRING (score=.826)
    HIF1AENSP000003380183STRING (score=.723)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019941 modification-dependent protein catabolic process IEA--
    GO:0043687 post-translational protein modification IEA--
    GO:0051246 regulation of protein metabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for UBE2S

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBE2S)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (UBE2S)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014501

                  Sigma-Aldrich siRNA and siRNA Panels for UBE2S  
                         Sigma-Aldrich shRNA Panels and shRNA for UBE2S  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_014501  

    REFSEQ mRNAs for UBE2S gene: 

    NM_014501.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_014501  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_014501
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_014501
                                     untagged cDNA clones in CMV expression vector (see all 2): BC066948 

    Additional cDNA sequence: 

    AB062397.1 BC004236.2 BC007554.1 BC065364.1 BC066948.1 CR594048.1 CR596308.1 CR611408.1 
    CR618880.1 CR622781.1 CR626565.1 M91670.1 

    21 DOTS entries:

    DT.99948312  DT.100793466  DT.451729  DT.121503213  DT.100793470  DT.120974316  DT.121503215  DT.100793463 
    DT.95269991  DT.100793465  DT.121004353  DT.436623  DT.91762377  DT.92412032  DT.120974360  DT.121503180 
    DT.121503189  DT.99991873  DT.121503229  DT.91653365  DT.91762375 

    24/385 AceView cDNA sequences (see all 385 ):

    BE791805 BQ961491 BQ926180 BI093302 CR618880 BM782899 CR594048 BU739658 
    BF035772 BG116513 AA355115 BI856833 BF718773 BE382478 AI865061 BG179097 
    M91670 BE262243 CR622781 BE253593 T19021 BM794482 BG118308 BG250687 

    highest scoring ESTs for UBE2S:

    M91670 AB062397 AL524393 AL524942 AW409921 BC004236 BC007554 BC065364 BE252503 BE253593 

    Unigene Cluster for UBE2S:

    Ubiquitin-conjugating enzyme E2S
    Hs.396393  [show with all ESTs]
    Unigene Representative Sequence: BM479313


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000264552  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    UBE2S expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for UBE2S

    1 / 2 / 3

    5 probe-sets matching UBE2S gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    894_g_at2, 3 U95-A 3 1.00 0.52 0.90 1.10 M91670 1.00 0.90 0.95 1
    40619_at2, 3 U95-A 3 1.00 0.50 0.98 0.91 M91670 1.00 0.90 0.95 1
    893_at2, 3 U95-A 3 1.00 0.36 0.99 1.00 M91670 1.00 0.90 0.95 1

    202779_s_at2, 3 U133-A 3 1.00 0.35 -- -- NM_014501 0.60 1.00 0.82 1

    202779_s_at2 U133Plus2 3 1.00 0.35 -- -- -- -- -- -- --
    GeneDecks  UBE2S for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTGGCGAGCG

    SOURCE GeneReport for Unigene cluster: Hs.396393

    Expression variation in blood from EXPOLDB for UBE2S

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for UBE2S gene from 5/15 species (see all 15 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    UBE2S1   -- ubiquitin-conjugating enzyme E2S 88.59(n)
    95.5(a)
    403671  XM_541410.2  XP_541410.2 
    chimpanzee
    (Pan troglodytes)
    UBE2S1   -- ubiquitin-conjugating enzyme E2S 99.4(n)
    99.55(a)
    456304  XM_512912.2  XP_512912.2 
    cow
    (Bos taurus)
    UBE2S1   -- ubiquitin-conjugating enzyme E2S 89.79(n)
    95.5(a)
    617703  NM_001076472.1  NP_001069940.1 
    rat
    (Rattus norvegicus)
    Ube2s1   -- ubiquitin-conjugating enzyme E2S 87.39(n)
    94.14(a)
    292588  XM_214806.4  XP_214806.1 
    mouse
    (Mus musculus)
    Ube2s5 7 ubiquitin-conjugating enzyme E2S   -- BG086766 
    About this table        Species with no ortholog for UBE2S

    ENSEMBL Gene Tree for UBE2S
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for UBE2S gene
    UBE2L62  UBE2I2  UBE2L32  

    Pseudogenes
    1 related pseudogene


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/44 NCBI SNPs in UBE2S are shown (see all 44 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 22)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs15515631,2
    A,C,F,H60612146(+) CCCTCT/CCGGTG 1 -- ng318Minor allele frequency- C:0.03EA NA EU WA 570
    rs116697321,2
    A,C,F,H60604144(+) AGGAAC/TACCAC 1 -- ng514Minor allele frequency- T:0.42EU EA WA 420
    --
    rs104033611,2
    A,F,H60604287(+) CTACCT/CCCACA 1 -- ng513Minor allele frequency- C:0.04EU EA 298
    rs118822581,2
    A,F,H60612976(+) CCATCC/TGCTAT 1 -- ng314Minor allele frequency- T:0.01EU EA WA 418
    --
    rs118816011,2
    F,H60612334(+) AATCTA/GCATGG 1 -- ng31 tfbs34Minor allele frequency- G:0.04EU EA WA 420
    rs104084481,2
    F,H60611960(+) GAAATG/TGACAC 1 -- ng314Minor allele frequency- T:0.04EU EA WA 420
    rs118807971,2
    C60611215(+) GGGGAA/GGAAGA 1 -- ng31 trp30--------
    --
    rs104028261,2
    C60604565(+) TTGGAC/GGGAGG 1 -- ut31 trp30--------
    rs76081,2
    C,F60604850(-) TATGCG/AGCTCG 1 A/A syn13Minor allele frequency- A:0.47MN 556
    --
    rs116720751,2
    A,C,F,H60606186(+) caggaC/Tgcctc 1 -- int13Minor allele frequency- T:0.15EU EA 300
    About this table

    HapMap Linkage Disequilibrium images for UBE2S (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610309

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    6 PubMed articles for UBE2S gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 27338 HGNC: 17895 AceView: UBE2S Ensembl:ENSG00000108106 euGenes: HUgn27338
    ECgene: UBE2S H-InvDB: UBE2S
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for UBE2S Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for UBE2S:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for UBE2S-related products

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     Predesigned and custom siRNAs for UBE2S Antibodies for UBE2S
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for UBE2S Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (E2 EPF)
     Antibodies (E2 EPF)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for UBE2S




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for UBE2S

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