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UBE2R2 Gene

protein-coding   GIFtS: 59
GCID: GC09P033817

Ubiquitin-Conjugating Enzyme E2R 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2R 21 2     CDC34B2 3
UBC3B2 3 5     EC 6.3.2.193 8
Ubiquitin Carrier Protein R22 3     E2-CDC34B2
Ubiquitin-Conjugating Enzyme E2-CDC34B2 3     Ubiquitin-Conjugating Enzyme E2 R22
Ubiquitin-Protein Ligase R22 3     Ubiquitin-Conjugating Enzyme UBC3B2

External Ids:    HGNC: 199071   Entrez Gene: 549262   Ensembl: ENSG000001073417   OMIM: 6125065   UniProtKB: Q712K33   

Export aliases for UBE2R2 gene to outside databases

Previous GC identifers: GC09P033987 GC09P033807 GC09P033774


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2R2 Gene:
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and
transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies
suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP
substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. (provided
by RefSeq, Jul 2008)

GeneCards Summary for UBE2R2 Gene:
UBE2R2 (ubiquitin-conjugating enzyme E2R 2) is a protein-coding gene. Diseases associated with UBE2R2 include cblc, and herpes simplex. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2G2.

UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin

Gene Wiki entry for UBE2R2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000009.12  NT_008413.19  NC_018920.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2R2 gene promoter:
         Bach1   AML1a   Pax-5   ATF-2   LCR-F1   GATA-1   E47   CREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2R2 promoter sequence
   Search Chromatin IP Primers for UBE2R2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2R2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p11.2

UBE2R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2R2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033817:  view genomic region     (about GC identifiers)

Start:
33,817,182 bp from pter      End:
33,920,402 bp from pter
Size:
103,221 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 R2  
Size: 238 amino acids; 27166 Da
Subunit: When phosphorylated, interacts with beta-TrCP (BTRC)
Secondary accessions: D3DRL5 Q9NX64

Explore the universe of human proteins at neXtProt for UBE2R2: NX_Q712K3

Explore proteomics data for UBE2R2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys63
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2R2 (Q712K3) (see all 7)
     VCISILH  LQEEPVEGFR  KFPIDYPYSPP  LLSVISLLNEPN 


    See UBE2R2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060281.2  
    ENSEMBL proteins: 
     ENSP00000263228  
    Reactome Protein details: Q712K3

    UBE2R2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for UBE2R2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q712K3

    ProtoNet protein and cluster: Q712K3

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2R2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2R2_HUMAN, Q712K3
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2R2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2R2:
     Increased cell death HMECs cel  Increased gamma-H2AX phosphory  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2R2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2R2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2R2

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2R2:
    hsa-mir-92a-3p (MIRT049547), hsa-mir-93-3p (MIRT038898), hsa-mir-103a-3p (MIRT027175), hsa-mir-7-5p (MIRT025944), hsa-mir-124-3p (MIRT023173)

    Block miRNA regulation of human, mouse, rat UBE2R2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2R2 (see all 114):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-411 hsa-miR-30d hsa-miR-502-3p hsa-miR-30a hsa-miR-383 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE2R2

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for UBE2R2 (see all 7)
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    GenScript: all cDNA clones in your preferred vector: UBE2R2 (NM_017811)
    Sino Biological Human cDNA Clone for UBE2R2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2R2
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2R2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol1
    nucleus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2R2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Influenza A
    Herpes simplex infection0.33
    3Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    4Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2R2
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions


    1 Reactome Pathway for UBE2R2
        Antigen processing: Ubiquitination & Proteasome degradation


    2 Kegg Pathways  (Kegg details for UBE2R2):
        Ubiquitin mediated proteolysis
    Herpes simplex infection

    UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3
    Pathway: Protein modification; protein ubiquitination


    UBE2R2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2R2: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2R2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2R2 (Q712K32, 3 ENSP000002632284) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INF2Q27J812, 3, ENSP000003764104MINT-8276278 I2D: score=2 STRING: ENSP00000376410
    UBA52P629872, 3, ENSP000003881074MINT-8276304 I2D: score=2 STRING: ENSP00000388107
    ARHGDIAP525652, 3MINT-8276248 I2D: score=2 
    FBXW5Q969U62, 3, ENSP000003130344MINT-8276263 I2D: score=2 STRING: ENSP00000313034
    PNPLA2Q96AD52, 3, ENSP000003377014MINT-8276291 I2D: score=2 STRING: ENSP00000337701
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006513protein monoubiquitination IDA--
    GO:0070936protein K48-linked ubiquitination IDA--

    UBE2R2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2R2 (UB2R2)

    4 HMDB Compounds for UBE2R2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBE2R2 gene: 
    NM_017811.3  

    Unigene Cluster for UBE2R2:

    Ubiquitin-conjugating enzyme E2R 2
    Hs.643648  [show with all ESTs]
    Unigene Representative Sequence: NM_017811
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000263228(uc003ztm.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat UBE2R2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2R2 (see all 114):
    hsa-miR-3130-5p hsa-miR-520e hsa-miR-411 hsa-miR-30d hsa-miR-502-3p hsa-miR-30a hsa-miR-383 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2R2
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2R2
      QuantiFast Probe-based Assays in human, mouse, rat UBE2R2

    Additional mRNA sequence: 

    AJ240087.1 AK000426.1 AK225880.1 BC004862.2 BC038356.1 BC047584.1 CR457233.1 

    17 DOTS entries:

    DT.100825430  DT.454119  DT.100825439  DT.420317  DT.100825442  DT.92433220  DT.95150382  DT.100036350 
    DT.100825431  DT.121211030  DT.92433223  DT.99932360  DT.100825434  DT.100825440  DT.100825441  DT.95368200 
    DT.99946837 

    Selected AceView cDNA sequences (see all 414):

    BM668175 BQ676392 BU625506 BM972256 AI825040 T87855 BI092466 CB155756 
    W76225 W73579 R80083 BI061548 NM_017811 BE889731 AA713942 AI350363 
    T39232 AI650476 CK825704 T40487 BE464240 AA286768 BM456419 CB134174 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2R2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGGCCTCAG
    UBE2R2 Expression
    About this image


    UBE2R2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    UBE2R2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2R2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.643648
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2R2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for UBE2R2
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    QuantiTect SYBR Green Assays in human, mouse, rat UBE2R2
    QuantiFast Probe-based Assays in human, mouse, rat UBE2R2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2R2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE2R2 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2r21 , 5 ubiquitin-conjugating enzyme E2R 21, 5 94.4(n)1
    100(a)1
      4 (21.02 cM)5
    676151  NM_026275.41  NP_080551.11 
     411357435 
    chicken
    (Gallus gallus)
    Aves LOC4271341 ubiquitin-conjugating enzyme E2 R2-like 88.66(n)
    99.16(a)
      427134  XM_424727.4  XP_424727.3 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2R26
    ubiquitin-conjugating enzyme E2R 2
    97(a)
    1 ↔ 1
    GL343372.1(722738-791355)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC056005.12   -- 82.32(n)    BC056005.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044173.12   -- 75.69(n)   393933  BC044173.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76561 CG7656 68.25(n)
    74.74(a)
      39691  NM_001274956.1  NP_001261885.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-31 ubc-3 62.12(n)
    65.66(a)
      171734  NM_058481.5  NP_490882.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC341 CDC34 50.45(n)
    38.5(a)
      851624   NP_010339.1 


    ENSEMBL Gene Tree for UBE2R2 (if available)
    TreeFam Gene Tree for UBE2R2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2R2 gene
    UBE2G22  UBE2G12  CDC342  
    6 SIMAP similar genes for UBE2R2 using alignment to 2 protein entries:     UB2R2_HUMAN (see all proteins):
    CDC34    UBE2G1    UBE2B    UBE2G2    UBE2A    UBE2D1

    UBE2R2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2R2 (see all 2094)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1896503851,2
    --33815184(+) GAACAA/CAGTCT 1 -- us2k10--------
    rs1513302711,2
    --33815267(+) TCCTGC/GAACAG 1 -- us2k10--------
    rs1811724311,2
    --33815365(+) ACTCTA/GCTAAT 1 -- us2k10--------
    rs1853334361,2
    --33815413(+) GTAGGG/TGAACT 1 -- us2k10--------
    rs727253681,2
    C,F--33815455(+) AAACTG/ATCCTT 1 -- us2k11Minor allele frequency- A:0.10NA 120
    rs1406389311,2
    --33815598(+) ATTAGC/TTGGGC 1 -- us2k10--------
    rs1896903231,2
    --33815798(+) TTTTTA/TTCTTT 1 -- us2k10--------
    rs1500304461,2
    --33815804(+) TCTTTA/CAAGTT 1 -- us2k10--------
    rs1835406001,2
    --33815827(+) TAACCA/CTGTGC 1 -- us2k10--------
    rs109717111,2
    C,F,H--33815842(+) CACTAC/TGCTAA 1 -- us2k1 tfbs320Minor allele frequency- T:0.27NS EA NA CSA WA 2346

    HapMap Linkage Disequilibrium report for UBE2R2 (33817182 - 33920402 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for UBE2R2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2656909CNV Deletion23128226
    nsv831541CNV Loss17160897
    esv23020CNV Loss19812545
    nsv893030CNV Gain21882294
    nsv893029CNV Gain21882294
    nsv518977CNV Gain19592680
    nsv520467CNV Gain19592680
    nsv893028CNV Gain21882294
    dgv2311e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612506    OMIM disorders: --

    4 diseases for UBE2R2:    
    About MalaCards
    cblc    herpes simplex    hypertension    malaria


    UBE2R2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBE2R2
    Human Genome Epidemiology (HuGE) Navigator: UBE2R2 (3 documents)

    Export disorders for UBE2R2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2R2 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with UBE2R2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. (PubMed id 12037680)1, 2, 3 Semplici F.... Oliviero S. (Oncogene 2002)
    2. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. (PubMed id 23453757)1 Pierce N.W....Deshaies R.J. (Cell 2013)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 54926 HGNC: 19907 AceView: UBE2R2 Ensembl:ENSG00000107341 euGenes: HUgn54926
    ECgene: UBE2R2 Kegg: 54926 H-InvDB: UBE2R2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UBE2R2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UBE2R2 gene:
    Search GeneIP for patents involving UBE2R2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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