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Aliases for UBE2R2 Gene

Aliases for UBE2R2 Gene

  • Ubiquitin Conjugating Enzyme E2 R2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2-CDC34B 3 4
  • E2 Ubiquitin-Conjugating Enzyme R2 3 4
  • Ubiquitin Carrier Protein R2 3 4
  • Ubiquitin-Protein Ligase R2 3 4
  • CDC34B 3 4
  • UBC3B 3 4
  • Ubiquitin-Conjugating Enzyme E2R 2 2
  • Ubiquitin Conjugating Enzyme E2R 2 3
  • Ubiquitin-Conjugating Enzyme E2 R2 3
  • Ubiquitin-Conjugating Enzyme UBC3B 3
  • EC 6.3.2.19 58
  • EC 2.3.2.23 4
  • E2-CDC34B 3

External Ids for UBE2R2 Gene

Previous GeneCards Identifiers for UBE2R2 Gene

  • GC09P033987
  • GC09P033807
  • GC09P033774

Summaries for UBE2R2 Gene

Entrez Gene Summary for UBE2R2 Gene

  • Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2R2 Gene

UBE2R2 (Ubiquitin Conjugating Enzyme E2 R2) is a Protein Coding gene. Among its related pathways are Protein ubiquitination and Influenza A. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is CDC34.

UniProtKB/Swiss-Prot for UBE2R2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.

Gene Wiki entry for UBE2R2 Gene

Additional gene information for UBE2R2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2R2 Gene

Genomics for UBE2R2 Gene

Regulatory Elements for UBE2R2 Gene

Enhancers for UBE2R2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H033813 1.7 FANTOM5 ENCODE dbSUPER 15.8 -0.5 -453 6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF207 UBE2R2 UBAP1 PRSS3 ENSG00000260947 ENSG00000230074 UBAP2 DCAF12 GC09P034090
GH09H033778 1.3 Ensembl ENCODE dbSUPER 18 -37.5 -37524 2 CTCF PKNOX1 JUN ZNF2 RAD21 ZNF7 YY1 ZNF791 PATZ1 SMC3 UBE2R2 SMU1 TCEA1P4 NFX1 ENSG00000260947 TRBV29OR9-2 PRSS3
GH09H033850 0.8 Ensembl dbSUPER 20.2 +33.4 33437 1 FOXA2 RFX1 SAP130 ZNF585B SCRT2 REST FOXA1 UBE2R2 SNORD121A ENSG00000200834 GC09P034056
GH09H033842 0.8 Ensembl dbSUPER 19.8 +26.2 26237 1 PKNOX1 PRDM6 ZBTB33 MAFK UBE2R2 RNU4ATAC11P SNORD121B UBAP2 SNORD121A LINC01251 DCAF12 ENSG00000200834 GC09P034056
GH09H033852 1.2 Ensembl ENCODE dbSUPER 12.9 +35.1 35138 0 HDGF CTCF ZNF654 STAT1 REST RAD21 CC2D1A GATA3 ZNF143 SMC3 UBE2R2 SNORD121B UBAP2 SNORD121A DCAF12 GC09P034056 ENSG00000200834
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2R2 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2R2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234447 936 3001 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for UBE2R2 Gene

Chromosome:
9
Start:
33,817,164 bp from pter
End:
33,920,404 bp from pter
Size:
103,241 bases
Orientation:
Plus strand

Genomic View for UBE2R2 Gene

Genes around UBE2R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2R2 Gene

Proteins for UBE2R2 Gene

  • Protein details for UBE2R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q712K3-UB2R2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 R2
    Protein Accession:
    Q712K3
    Secondary Accessions:
    • D3DRL5
    • Q9NX64

    Protein attributes for UBE2R2 Gene

    Size:
    238 amino acids
    Molecular mass:
    27166 Da
    Quaternary structure:
    • When phosphorylated, interacts with beta-TrCP (BTRC).

neXtProt entry for UBE2R2 Gene

Selected DME Specific Peptides for UBE2R2 Gene

Q712K3:
  • LQEEPVEGFR
  • LLSVISLLNEPN
  • KFPIDYPYSPP
  • DLYNWEVAIFGPPNT
  • DGVKVPTTLAEYC
  • VCISILH
  • FRFLTKMWHPNIYE

Post-translational modifications for UBE2R2 Gene

  • Ubiquitination at Lys11 and Lys63
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2R2 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2R2 (UBC3B)
  • Abcam antibodies for UBE2R2

Domains & Families for UBE2R2 Gene

Gene Families for UBE2R2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UBE2R2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q712K3

UniProtKB/Swiss-Prot:

UB2R2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2R2: view

Function for UBE2R2 Gene

Molecular function for UBE2R2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.

Enzyme Numbers (IUBMB) for UBE2R2 Gene

Phenotypes From GWAS Catalog for UBE2R2 Gene

Gene Ontology (GO) - Molecular Function for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with UBE2R2: view
genes like me logo Genes that share phenotypes with UBE2R2: view

Animal Model Products

CRISPR Products

miRNA for UBE2R2 Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBE2R2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2R2 Gene

Localization for UBE2R2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2R2 gene
Compartment Confidence
cytosol 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2R2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2R2 Gene

Pathways & Interactions for UBE2R2 Gene

genes like me logo Genes that share pathways with UBE2R2: view

UniProtKB/Swiss-Prot Q712K3-UB2R2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2R2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IDA 20061386
GO:0016567 protein ubiquitination TAS --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0070936 protein K48-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2R2: view

Drugs & Compounds for UBE2R2 Gene

(3) Drugs for UBE2R2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
ATP Nutra Agonist 0

(1) Additional Compounds for UBE2R2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2R2: view

Transcripts for UBE2R2 Gene

mRNA/cDNA for UBE2R2 Gene

Unigene Clusters for UBE2R2 Gene

Ubiquitin-conjugating enzyme E2R 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBE2R2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2R2 Gene

No ASD Table

Relevant External Links for UBE2R2 Gene

GeneLoc Exon Structure for
UBE2R2
ECgene alternative splicing isoforms for
UBE2R2

Expression for UBE2R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2R2 Gene

This gene is overexpressed in Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for UBE2R2 Gene

This gene is overexpressed in Heart (19.5) and Cervix (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2R2 Gene



Protein tissue co-expression partners for UBE2R2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2R2 Gene:

UBE2R2

SOURCE GeneReport for Unigene cluster for UBE2R2 Gene:

Hs.643648

Evidence on tissue expression from TISSUES for UBE2R2 Gene

  • Lung(4.6)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with UBE2R2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2R2 Gene

Orthologs for UBE2R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2R2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 34
  • 100 (a)
OneToMany
UBE2R2 33 34
  • 99.63 (n)
oppossum
(Monodelphis domestica)
Mammalia UBE2R2 34
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2R2 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2R2 33 34
  • 96.5 (n)
cow
(Bos Taurus)
Mammalia UBE2R2 34 33
  • 95.8 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2r2 33 16 34
  • 94.4 (n)
rat
(Rattus norvegicus)
Mammalia LOC689226 33
  • 94.12 (n)
chicken
(Gallus gallus)
Aves UBE2R2 34
  • 99 (a)
OneToMany
-- 34
  • 95 (a)
OneToMany
LOC427134 33
  • 88.66 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2R2 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2r2 33
  • 82.35 (n)
zebrafish
(Danio rerio)
Actinopterygii ube2r2 33 34
  • 79.64 (n)
-- 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008680 33
  • 68.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7656 33 34
  • 68.25 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-3 33 34
  • 62.12 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL203C 33
  • 51.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC34 33
  • 50.45 (n)
UBC7 34
  • 44 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09196g 33
  • 47.91 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 63 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01188 33
  • 50.2 (n)
Species where no ortholog for UBE2R2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2R2 Gene

ENSEMBL:
Gene Tree for UBE2R2 (if available)
TreeFam:
Gene Tree for UBE2R2 (if available)

Paralogs for UBE2R2 Gene

Paralogs for UBE2R2 Gene

(6) SIMAP similar genes for UBE2R2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBE2R2: view

Variants for UBE2R2 Gene

Sequence variations from dbSNP and Humsavar for UBE2R2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000049227 -- 33,872,293(+) GAGGC(G/T)GAGGC intron-variant
rs1000063236 -- 33,888,962(+) CTTTT(A/T)CAGAC intron-variant
rs1000077579 -- 33,855,737(+) AGGCT(G/T)GAACA intron-variant
rs1000085407 -- 33,853,493(+) TTGGT(C/T)AGGCT intron-variant
rs1000133740 -- 33,893,059(+) CAGAG(C/G)AAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2R2 Gene

Variant ID Type Subtype PubMed ID
esv23020 CNV loss 19812545
esv2656909 CNV deletion 23128226
esv2759690 CNV gain 17122850
esv2761525 CNV gain 21179565
esv3409915 CNV insertion 20981092
esv3620335 CNV gain 21293372
esv3620336 CNV loss 21293372
esv3620337 CNV loss 21293372
nsv1125318 OTHER inversion 24896259
nsv1132190 CNV deletion 24896259
nsv476684 CNV novel sequence insertion 20440878
nsv518977 CNV gain 19592680
nsv520467 CNV gain 19592680
nsv614152 CNV gain 21841781
nsv614153 CNV loss 21841781
nsv831541 CNV loss 17160897

Variation tolerance for UBE2R2 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2R2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2R2 Gene

Disorders for UBE2R2 Gene

Relevant External Links for UBE2R2

Genetic Association Database (GAD)
UBE2R2
Human Genome Epidemiology (HuGE) Navigator
UBE2R2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2R2

No disorders were found for UBE2R2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2R2 Gene

Publications for UBE2R2 Gene

  1. CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. (PMID: 12037680) Semplici F … Oliviero S (Oncogene 2002) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 45 60
  4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 60
  5. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 45 60

Products for UBE2R2 Gene

Sources for UBE2R2 Gene

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