UBE2R2 Gene
protein-coding GIFtS: 56
GCID: GC09P033817
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ubiquitin-conjugating enzyme E2R 2
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Aliases for UBE2R2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2R 21 2 | | EC 6.3.2.193 8 | | UBC3B1 2 3 5 | | FLJ204191 | | CDC34B1 2 3 | | MGC104811 | | Ubiquitin Carrier Protein R22 3 | | E2-CDC34B2 | | Ubiquitin-Conjugating Enzyme E2-CDC34B2 3 | | Ubiquitin-Conjugating Enzyme E2 R22 | | Ubiquitin-Protein Ligase R22 3 | | Ubiquitin-Conjugating Enzyme UBC3B2 |
Export aliases for UBE2R2 gene to outside databasesPrevious GC identifers: GC09P033987 GC09P033807 GC09P033774 |
Summaries for UBE2R2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for UBE2R2: Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation.This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest thatCK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substraterecognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. (provided by RefSeq, Jul2008) UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin Gene Wiki entry for UBE2R2
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Genomic Views for UBE2R2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UBE2R2 gene promoter: Bach1 AML1a Pax-5 ATF-2 LCR-F1 GATA-1 E47 CREB Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2R2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2R2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p11.2UBE2R2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P033817: view genomic region
(about GC identifiers)
Start:
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33,817,182 bp from pter |
End:
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33,920,402 bp from pter |
Size:
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103,221 bases |
Orientation:
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plus strand |
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Proteins for UBE2R2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 R2 Size: 238 amino acids; 27166 Da
Subunit: When phosphorylated, interacts with beta-TrCP (BTRC)
Secondary accessions: D3DRL5 Q9NX64Explore the universe of human proteins at neXtProt for UBE2R2: NX_Q712K3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q712K3 4/7 DME Specific Peptides for UBE2R2 (Q712K3) (see all 7)
UBE2R2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060281.2 ENSEMBL proteins: ENSP00000263228 Reactome Protein details: Q712K3 Human Recombinant Protein Products:
UBE2R2 Antibody Products: Assay Products for UBE2R2: |
Protein
Domains / Families for UBE2R2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2R2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q712K3ProtoNet protein and cluster: Q712K3 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function for UBE2R2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of kateninCatalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.191 2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2R2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2R2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBE2R2 (NM_017811) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2R2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2R2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2R2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IDA | -- | | GO:0005524 | ATP binding |
IEA | -- |
UBE2R2 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for UBE2R2:
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Pathways & Interactions for UBE2R2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | Ubiquitin-Proteasome Dependent Proteolysis | | | 4 | Remodeling of Adherens Junctions | |
Pathway sources See GeneCards unified pathways Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2R2 5
Reactome Pathways for UBE2R2
1
Kegg Pathway (Kegg details for UBE2R2): UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3Pathway: Protein modification; protein ubiquitination
UBE2R2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2R2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
 5/17 Interacting proteins for UBE2R2 (Q712K32, 3 ENSP000002632284) via UniProtKB, MINT, STRING, and/or I2D (see all 17) About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006513 | protein monoubiquitination |
IDA | -- | | GO:0070936 | protein K48-linked ubiquitination |
IDA | -- |
UBE2R2 for ontologies About GeneDecksing
|
Drugs & Compounds for UBE2R2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for UBE2R2
4 HMDB Compounds for UBE2R2 About this table Search CenterWatch for drugs/clinical trials and news about UBE2R2 / UB2R2 
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Transcripts for UBE2R2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for UBE2R2 gene: NM_017811.3 Unigene Cluster for UBE2R2: Ubiquitin-conjugating enzyme E2R 2 Hs.740452 [show with all ESTs]Unigene Representative Sequence: NM_0178111 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000263228(uc003ztm.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2R2 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2R2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBE2R2 (NM_017811) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2R2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2R2  |
Additional cDNA sequence: AJ240087.1 AK000426.1 AK225880.1 BC004862.2 BC038356.1 BC047584.1 CR457233.1 16 DOTS entries: DT.100825430 DT.454119 DT.420317 DT.100825439 DT.100825442 DT.95150382 DT.92433220 DT.100825431 DT.100036350 DT.92433223 DT.99932360 DT.100825434 DT.100825440 DT.100825441 DT.121211030 DT.95368200 24/414 AceView cDNA sequences (see all 414): AA740851 AW152135 AI124729 BE464240 BG502595 AA043373 AA063147 AA147478 CB159642 N66262 CA431108 BF351857 BM786719 CB155756 BQ448284 BM972256 BE889731 AI350363 AI141821 NM_017811 AI650476 CD243112 R80083 AA397839 GeneLoc Exon Structure
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Expression for UBE2R2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2R2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GAGGCCTCAG
About this image See UBE2R2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UBE2R2
SOURCE GeneReport for Unigene cluster: Hs.740452 SABiosciences Expression via Pathway-Focused PCR Array including UBE2R2: | Ubiquitination (Ubiquitylation) Pathway in human mouse rat |
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2R2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2R2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2R2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2R2 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2R2 |
Orthologs for UBE2R2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for UBE2R2 gene from 7/27 species (see all 27) About this table
ENSEMBL Gene Tree for UBE2R2 (if available) TreeFam Gene Tree for UBE2R2 (if available)  |
Paralogs for UBE2R2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for UBE2R2 gene
- CDC342
6 SIMAP similar genes for UBE2R2 using alignment to 2 protein entries: UB2R2_HUMAN (see all proteins):CDC34 UBE2G1 UBE2B UBE2G2 UBE2A UBE2D1
UBE2R2 for paralogs About GeneDecksing
|
Genomic Variants for UBE2R2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 9 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for UBE2R2 (33817182 - 33920402 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for UBE2R2 1 CNV: 2815 1 Indel: 70539  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2R2 |
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Disorders
/ Diseases for UBE2R2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2R2 for disorders About GeneDecksing
OMIM gene information: 612506
OMIM disorders: --
1 disease for UBE2R2: About MalaCardscblc Human Genome Epidemiology (HuGE) Navigator: UBE2R2 (3 documents) Export disorders for UBE2R2 gene to outside databases
|
Publications for UBE2R2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBE2R2 gene, integrated from 9 sources (see all 20): (articles sorted by number of sources associating them with UBE2R2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. (PubMed id 12037680)1, 2, 3 Semplici F.... Oliviero S. (2002)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
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External Searches for UBE2R2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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|
Genome Databases showing UBE2R2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2R2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2R2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for UBE2R2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBE2R2 gene: Search GeneIP for patents involving UBE2R2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for UBE2R2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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 | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2R2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2R2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2R2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2R2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2R2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2R2 |
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 | | UBE2R2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2R2 |
|  |  |  | | | Search ThermoFisher Antibodies for UBE2R2 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2R2 |
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