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UBE2R2 Gene

protein-coding   GIFtS: 51

GC09P033807
ubiquitin-conjugating enzyme E2R 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CDC34B 1, 2, 3
E2-CDC34B 3
EC 6.3.2.19 3
FLJ20419 1, 2
MGC10481 1, 2
OTTHUMP00000000472 2
OTTHUMP00000021236 2
UBC3B 1, 2, 3, 5
Descriptions
Ubiquitin carrier protein R2 2, 3
Ubiquitin-protein ligase R2 2, 3
ubiquitin-conjugating enzyme E2R 2 2
ubiquitin-conjugating enzyme UBC3B 2
External Ids
HGNC: 199071
Entrez Gene: 549262
UniProtKB: Q712K33
Ensembl: ENSG000001073417
Search outside databases for aliases for UBE2R2 gene

Previous GC identifer: GC09P033987

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for UBE2R2:
Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth
and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme
UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating
enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with
beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq]

UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in
degradation of katenin

Gene Wiki entry for UBE2R2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the UBE2R2 gene  

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p11.2

UBE2R2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P033807:     (about GC identifiers)

Start:
33,807,182 bp from pter
End:
33,910,401 bp from pter
Size:
103,220 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 R2  
Size: 238 amino acids; 27166 Da
Subunit: When phosphorylated, interacts with beta-TrCP (BTRC)
Secondary accessions: Q9NX64

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_060281.2  

    ENSEMBL proteins: 
    ENSP00000263228 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (UBE2R2)
                  OriGene Purified Recombinant Human Protein: UBE2R2 


    Antibodies for UBE2R2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (UBE2R2)
    Novus Biologicals Antibody for UBE2R2

    Assays for UBE2R2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugat/RWD-like


       GeneDecks  UBE2R2 for the domains selected above  
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    Graphical View of Domain Structure for InterPro Entry Q712K3

    ProtoNet protein and cluster: Q712K3

    1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3
    Similarity: Belongs to the ubiquitin-conjugating enzyme family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBE2R2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (UBE2R2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017811

                  Applied Biosystems Silencer® siRNAs for UBE2R2

                  Sigma-Aldrich siRNA and siRNA Panels for UBE2R2  
                         Sigma-Aldrich shRNA Panels and shRNA for UBE2R2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017811
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017811
                                     untagged cDNA clone in CMV expression vector: NM_017811 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_017811

    UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in
    degradation of katenin
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein
    N-ubiquityllysine
    Enzyme Number (IUBMB): EC 6.3.2.19 

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842 ubiquitin-protein ligase activity IEA--
    GO:0016874 ligase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  UBE2R2  (Your Favorite Gene powered by Ingenuity) 
     Hypoxia Signaling in the Cardiovascular System
     Protein Ubiquitination Pathway

       GeneDecks  UBE2R2 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for UBE2R2):
     hsa04120 Ubiquitin mediated proteolysis

       GeneDecks  UBE2R2 for the pathways selected above  
    About GeneDecksing
    UniProtKB/Swiss-Prot: UB2R2_HUMAN, Q712K3
    Pathway: Protein modification; protein ubiquitination

     Gene Network CentralTM Interacting Genes and Proteins Network for  UBE2R2 


    5/6 Interacting proteins for UBE2R2 (ENSP000002632283) via UniProtKB, MINT, and/or STRING (see all 6 )

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCENSP000003592063STRING (score=.968)
    UBA1ENSP000003384133STRING (score=.96)
    UBA6ENSP000003134543STRING (score=.913)
    CDC34ENSP000002155743STRING (score=.803)
    CSNK2A1PENSP000003714003STRING (score=.77)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019941 modification-dependent protein catabolic process IEA--
    GO:0043687 post-translational protein modification IEA--
    GO:0051246 regulation of protein metabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for UBE2R2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBE2R2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (UBE2R2)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017811

                  Sigma-Aldrich siRNA and siRNA Panels for UBE2R2  
                         Sigma-Aldrich shRNA Panels and shRNA for UBE2R2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_017811  

    REFSEQ mRNAs for UBE2R2 gene: 

    NM_017811.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_017811  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_017811
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_017811
                                     untagged cDNA clone in CMV expression vector: NM_017811 

    Additional cDNA sequence: 

    AJ240087.1 AK000426.1 AK225880.1 BC004862.2 BC047584.1 CR457233.1 CR592127.1 CR606642.1 
    CR626708.1 

    15 DOTS entries:

    DT.100825430  DT.454119  DT.420317  DT.100825439  DT.100825442  DT.95150382  DT.100825431  DT.100036350 
    DT.92433223  DT.100825441  DT.121211030  DT.92433220  DT.95368200  DT.100825434  DT.100825440 

    24/414 AceView cDNA sequences (see all 414 ):

    BG502595 AW152135 BM697411 AA063147 CB132676 CA431108 AW572093 BM786719 
    CD243112 BQ285892 NM_017811 AA286768 BQ448284 BE889731 CR626708 BI092466 
    AA988071 BI061548 AI350363 CR592127 AA835694 CB159642 W76225 T87855 

    highest scoring ESTs for UBE2R2:

    Z78377 AA010793 AA029820 AA029821 AA043373 AA044661 AA044888 AA084062 AA084172 AA147324 

    Unigene Cluster for UBE2R2:

    Ubiquitin-conjugating enzyme E2R 2
    Hs.718444  [show with all ESTs]
    Unigene Representative Sequence: NM_017811


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000263228  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    UBE2R2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for UBE2R2

    1 / 2 / 3

    6 probe-sets matching UBE2R2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    56479_at2, 3 U95-B 1 1.00 1.00 0.84 1.11 Z78377 1.00 1.00 1.00 1
    46616_at2, 3 U95-B 1 1.00 1.00 0.75 0.89 AI969737 0.40 1.00 0.76 1

    226954_at2, 3 U133-B 1 1.00 1.00 -- -- BE221883 0.60 1.00 0.82 1

    223014_at2, 3 U133-B 1 1.00 1.00 -- -- BC004862 0.80 0.83 0.82 1

    226954_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    223014_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  UBE2R2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGGCCTCAG

    SOURCE GeneReport for Unigene cluster: Hs.718444
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for UBE2R2 gene from 5/17 species (see all 17 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    UBE2R21   -- ubiquitin-conjugating enzyme E2R 2 96.5(n)
    100(a)
    611799  XM_849513.1  XP_854606.1 
    chimpanzee
    (Pan troglodytes)
    UBE2R21   -- ubiquitin-conjugating enzyme E2R 2 100(n)
    100(a)
    465050  XM_520535.2  XP_520535.2 
    cow
    (Bos taurus)
    UBE2R21   -- ubiquitin-conjugating enzyme E2R 2 95.8(n)
    100(a)
    537885  XM_618072.3  XP_618072.3 
    rat
    (Rattus norvegicus)
    LOC6892261   -- similar to ubiquitin-conjugating enzyme E2R 2 88.94(n)
    93.7(a)
    689226  XM_001064957.1  XP_001064957.1 
    mouse
    (Mus musculus)
    Ube2r21, 5 45
    ubiquitin-conjugating enzyme E2R 21, 5 94.4(n)1
    100(a)1
    676151  NM_026275.31  NP_080551.11 
     AJ2400865  AK0035505  (see all 22)
    About this table        Species with no ortholog for UBE2R2

    ENSEMBL Gene Tree for UBE2R2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for UBE2R2 gene
    CDC342  UBE2W2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/693 NCBI SNPs in UBE2R2 are shown (see all 693 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 155)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs48171,2
    A,C,F,H33907498(+) AAAAAT/CATGAA 1 -- ut3111Minor allele frequency- C:0.33MN EA EU WA 2690
    rs38145111,2
    C,F,H33806476(-) AACTGG/AGTCTC 1 -- ng5110Minor allele frequency- A:0.15MN EA EU WA 1192
    rs8557191,2
    A,C33807617(+) TGGTCC/TGGCCC 1 -- ut510--------
    --
    rs101235451,2
    A,C33806743(+) AGCGAC/TCAGGC 1 -- ng510--------
    rs38145121,2
    C,F33806277(+) GGGGGG/CACCAA 1 -- ng512Minor allele frequency- C:0.01MN EA 356
    rs169352781,2
    F,H33909176(+) TTACAA/CACTCT 1 -- ut31 ese37Minor allele frequency- C:0.06NA EU EA WA 560
    --
    rs38244611,2
    A,C33907715(+) AAAAAA/GCAAAT 1 -- ut31 trp30--------
    --
    rs109717111,2
    F,H33805842(+) CACTAC/TGCTAA 1 -- ng51 tfbs34Minor allele frequency- T:0.33EU EA WA 420
    rs132988061,2
    H33910865(+) CTCAAT/CTGTAG 1 -- ng314Minor allele frequency- C:0.00EU EA WA 416
    rs7333841,2
    H33910451(-) AATGAG/CACCAC 1 -- ng317Minor allele frequency- C:0.00EA NA EU WA 458
    About this table

    HapMap Linkage Disequilibrium images for UBE2R2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 612506

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for UBE2R2 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 54926 HGNC: 19907 AceView: UBE2R2 Ensembl:ENSG00000107341 euGenes: HUgn54926
    ECgene: UBE2R2 H-InvDB: UBE2R2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for UBE2R2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for UBE2R2 Antibodies for UBE2R2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for UBE2R2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     shRNA in GFP-retroviral vector
     Search Tocris compounds for UBE2R2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for UBE2R2

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