Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBE2R2 Gene

Aliases for UBE2R2 Gene

  • Ubiquitin-Conjugating Enzyme E2R 2 2 3
  • UBC3B 3 4 6
  • Ubiquitin-Conjugating Enzyme E2-CDC34B 3 4
  • Ubiquitin Carrier Protein R2 3 4
  • Ubiquitin-Protein Ligase R2 3 4
  • EC 4 64
  • CDC34B 3 4
  • Ubiquitin-Conjugating Enzyme E2 R2 3
  • Ubiquitin-Conjugating Enzyme UBC3B 3
  • E2-CDC34B 3

External Ids for UBE2R2 Gene

Summaries for UBE2R2 Gene

Entrez Gene Summary for UBE2R2 Gene

  • Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2R2 Gene

UBE2R2 (Ubiquitin-Conjugating Enzyme E2R 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2G1.

UniProtKB/Swiss-Prot for UBE2R2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.

Gene Wiki entry for UBE2R2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2R2 Gene

Genomics for UBE2R2 Gene

Genomic Location for UBE2R2 Gene

33,817,164 bp from pter
33,920,404 bp from pter
103,241 bases
Plus strand

Genomic View for UBE2R2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2R2 Gene

Regulatory Elements for UBE2R2 Gene

Proteins for UBE2R2 Gene

  • Protein details for UBE2R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 R2
    Protein Accession:
    Secondary Accessions:
    • D3DRL5
    • Q9NX64

    Protein attributes for UBE2R2 Gene

    238 amino acids
    Molecular mass:
    27166 Da
    Quaternary structure:
    • When phosphorylated, interacts with beta-TrCP (BTRC).

neXtProt entry for UBE2R2 Gene

Proteomics data for UBE2R2 Gene at MOPED

Post-translational modifications for UBE2R2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11 and Lys63

Other Protein References for UBE2R2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UBE2R2 Gene

Gene Families for UBE2R2 Gene

  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2R2 Gene


  • Belongs to the ubiquitin-conjugating enzyme family.:
    • Q712K3
genes like me logo Genes that share domains with UBE2R2: view

Function for UBE2R2 Gene

Molecular function for UBE2R2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and Lys-48-linked polyubiquitination. May be involved in degradation of katenin.

Enzyme Numbers (IUBMB) for UBE2R2 Gene

Gene Ontology (GO) - Molecular Function for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2R2: view

Phenotypes for UBE2R2 Gene

genes like me logo Genes that share phenotypes with UBE2R2: view

miRNA for UBE2R2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2R2 Gene

Localization for UBE2R2 Gene

Subcellular locations from

Jensen Localization Image for UBE2R2 Gene COMPARTMENTS Subcellular localization image for UBE2R2 gene
Compartment Confidence
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBE2R2: view

Pathways for UBE2R2 Gene

genes like me logo Genes that share pathways with UBE2R2: view

UniProtKB/Swiss-Prot Q712K3-UB2R2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IDA 20061386
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0070936 protein K48-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2R2: view

Compounds for UBE2R2 Gene

(4) HMDB Compounds for UBE2R2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with UBE2R2: view

Transcripts for UBE2R2 Gene

mRNA/cDNA for UBE2R2 Gene

Unigene Clusters for UBE2R2 Gene

Ubiquitin-conjugating enzyme E2R 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2R2 Gene

No ASD Table

Relevant External Links for UBE2R2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2R2 Gene

mRNA expression in normal human tissues for UBE2R2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2R2 Gene

This gene is overexpressed in Whole Blood (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2R2 Gene

SOURCE GeneReport for Unigene cluster for UBE2R2 Gene Hs.643648

genes like me logo Genes that share expressions with UBE2R2: view

Orthologs for UBE2R2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 37
  • 100 (a)
UBE2R2 36
  • 99.63 (n)
  • 99.45 (a)
UBE2R2 37
  • 100 (a)
(Bos Taurus)
Mammalia UBE2R2 36
  • 95.8 (n)
  • 100 (a)
UBE2R2 37
  • 100 (a)
(Canis familiaris)
Mammalia UBE2R2 36
  • 96.5 (n)
  • 100 (a)
UBE2R2 37
  • 100 (a)
(Mus musculus)
Mammalia Ube2r2 36
  • 94.4 (n)
  • 100 (a)
Ube2r2 16
Ube2r2 37
  • 100 (a)
(Monodelphis domestica)
Mammalia UBE2R2 37
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2R2 37
  • 98 (a)
(Rattus norvegicus)
Mammalia LOC689226 36
  • 94.12 (n)
  • 100 (a)
(Gallus gallus)
Aves -- 37
  • 95 (a)
LOC427134 36
  • 88.66 (n)
  • 99.16 (a)
UBE2R2 37
  • 99 (a)
(Anolis carolinensis)
Reptilia UBE2R2 37
  • 97 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2r2 36
  • 82.35 (n)
  • 99.58 (a)
(Danio rerio)
Actinopterygii -- 36
ube2r2 36
  • 79.64 (n)
  • 94.09 (a)
ube2r2 37
  • 86 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008680 36
  • 68.71 (n)
  • 76.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7656 36
  • 68.25 (n)
  • 74.74 (a)
CG7656 37
  • 52 (a)
(Caenorhabditis elegans)
Secernentea ubc-3 36
  • 62.12 (n)
  • 65.66 (a)
ubc-3 37
  • 60 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL203C 36
  • 51.36 (n)
  • 42.77 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC34 36
  • 50.45 (n)
  • 38.5 (a)
UBC7 37
  • 44 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D09196g 36
  • 47.91 (n)
  • 39.89 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01188 36
  • 50.2 (n)
  • 41.18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 63 (a)
Species with no ortholog for UBE2R2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2R2 Gene

Gene Tree for UBE2R2 (if available)
Gene Tree for UBE2R2 (if available)

Paralogs for UBE2R2 Gene

Paralogs for UBE2R2 Gene

Selected SIMAP similar genes for UBE2R2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBE2R2: view

Variants for UBE2R2 Gene

Sequence variations from dbSNP and Humsavar for UBE2R2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs2196 -- 33,914,310(+) GAAAA(C/T)ACCCA intron-variant
rs4817 -- 33,917,500(+) AAAAA(C/T)ATGAA utr-variant-3-prime
rs216370 -- 33,822,096(+) TATAt(A/T)ttttt intron-variant
rs216371 -- 33,822,201(+) attct(C/T)ctgcc intron-variant
rs471371 -- 33,870,846(+) TTATT(C/T)CCTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2R2 Gene

Variant ID Type Subtype PubMed ID
nsv518977 CNV Gain 19592680
nsv893028 CNV Gain 21882294
dgv2311e1 CNV Complex 17122850
nsv520467 CNV Gain 19592680
esv23020 CNV Loss 19812545
nsv893029 CNV Gain 21882294
nsv831541 CNV Loss 17160897
nsv893030 CNV Gain 21882294
esv2656909 CNV Deletion 23128226

Relevant External Links for UBE2R2 Gene

HapMap Linkage Disequilibrium report

Disorders for UBE2R2 Gene

Relevant External Links for UBE2R2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with UBE2R2: view

No data available for UniProtKB/Swiss-Prot for UBE2R2 Gene

Publications for UBE2R2 Gene

  1. CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. (PMID: 12037680) Semplici F. … Oliviero S. (Oncogene 2002) 2 3 4
  2. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 49

Products for UBE2R2 Gene

  • antibodies-online proteins for UBE2R2
  • antibodies-online antibodies for UBE2R2
  • antibodies-online kits for UBE2R2

Sources for UBE2R2 Gene

Back to Top