UBE2QL1 Gene
protein-coding GIFtS : 41
GCID: GC05 P006448
ubiquitin-conjugating enzyme E2Q family-like 1
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Aliasesfor UBE2QL1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ubiquitin-Conjugating Enzyme E2Q Family-Like 1 1 2 FLJ250761 Ubiquitin-Conjugating Enzyme E2Q-Like Protein 12 EC 6.3.2.193
Export aliases for UBE2QL1 gene to outside databases
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Summariesfor UBE2QL1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167 Function : Catalyzes the covalent attachment of ubiquitin to other proteins (Potential)
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Genomic Viewsfor UBE2QL1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000005.9 NC_018916.1 NT_006576.16 Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for UBE2QL1 Other transcription factors Search SABiosciences Chromatin IP Primers for UBE2QL1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat UBE2QL1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 5p15.31 Ensembl cytogenetic band: 5p15.31 HGNC cytogenetic band: 5p15.31 UBE2QL1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05P006448: view genomic region
(about GC identifiers )
Start:
6,448,736 bp from pter
End:
6,495,022 bp from pter
Size:
46,287 bases
Orientation:
plus strand
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Proteinsfor UBE2QL1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167 (See
protein sequence )Recommended Name: Ubiquitin-conjugating enzyme E2Q-like protein 1 Size : 161 amino acids; 18338 Da
Sequence caution : Sequence=AAI27724.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=AAI50555.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Explore the universe of human proteins at neXtProt for UBE2QL1: NX_A1L167 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_A1L167 UBE2QL1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_001138633.1 ENSEMBL proteins: ENSP00000382713 Human Recombinant Protein Products: UBE2QL1 Antibody Products: Assay Products for UBE2QL1:
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Protein
Domains / Familiesfor UBE2QL1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
UBE2QL1 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry A1L167 ProtoNet protein and cluster: A1L167
UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167 Similarity : Belongs to the ubiquitin-conjugating enzyme family
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Functionfor UBE2QL1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167 Function : Catalyzes the covalent attachment of ubiquitin to other proteins (Potential)Catalytic activity : ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19 1
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2QL1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2QL1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UBE2QL1 (NM_001145161 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2QL1 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UBE2QL1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2QL1
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004842 ubiquitin-protein ligase activity
IEA -- GO:0005524 ATP binding
IEA --
UBE2QL1 for ontologies About GeneDecksing
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Pathways & Interactionsfor UBE2QL1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Antigen processing: Ubiquitination & Proteasome degradation
Pathway sources See GeneCards unified pathways Show all pathways 1
Kegg Pathway (Kegg details for UBE2QL1) :UniProtKB/Swiss-Prot: U2QL1_HUMAN, A1L167 Pathway : Protein modification; protein ubiquitination
UBE2QL1 for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2QL1 STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for UBE2QL1 (A1L167 3 ENSP00000382713 4 ) via UniProtKB, MINT, STRING , and/or I2D
About this table
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Drugs & Compoundsfor UBE2QL1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for UBE2QL1 Search CenterWatch for drugs/clinical trials and news about UBE2QL1 / U2QL1
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Transcriptsfor UBE2QL1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for UBE2QL1 gene: NM_001145161.2 Unigene Cluster for UBE2QL1:
Ubiquitin-conjugating enzyme E2Q family-like 1 Hs.126856 [show with all ESTs ] Unigene Representative Sequence: NM_001145161 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000399816 (uc003jdp.4 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2QL1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2QL1 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UBE2QL1 (NM_001145161 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2QL1 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UBE2QL1
Additional cDNA sequence: AB188494.1 AK057805.1 AK096612.1 AK308577.1 BC127723.1 BC150554.1
4 DOTS entries : DT.115035 DT.99994154
DT.75168789 DT.95159567 24/66 AceView cDNA sequences (see all 66 ):
AK096612 T16575 BE048820 F02655 Z45266 F10145 AI093318 AA948267 AI366013 BI792383 AA805324 BX420026 BE502530 AA449241 AW572911 F04161 AI953735 BF056928 AK057805 AI263703 AI651825 Z43784 BU727576 AI632565 GeneLoc Exon Structure
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Expression for UBE2QL1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section UBE2QL1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CATACCTGAA
About this image UBE2QL1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See UBE2QL1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UBE2QL1 SOURCE GeneReport for Unigene cluster: Hs.126856 SABiosciences Custom PCR Arrays for UBE2QL1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for UBE2QL1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat UBE2QL1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat UBE2QL1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat UBE2QL1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2QL1
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Orthologsfor UBE2QL1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for UBE2QL1 gene from 6/19 species (see all 19 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Ube2ql11 , 5
ubiquitin-conjugating enzyme E2Q family-like 11, 5
94.82(n) 1 98.76(a) 1
 
13 (35.55 cM) 5 76980 1 NM_001145162.1 1 NP_001138634.1 1 69702835 5
chicken (Gallus gallus)
Aves
UBE2QL16
Uncharacterized protein
99(a)
1 ↔ 1
2(82108101-82123122)
lizard (Anolis carolinensis)
Reptilia
UBE2QL16
--
98(a)
1 ↔ 1
GL343211.1(2418288-2452137)
African clawed frog (Xenopus laevis)
Amphibia
Xl.74152
Xenopus laevis transcribed sequence with weak similarity to protein refNP_492764.1 (C.elegans) F25H2.8.p [Caenorhabditis elegans] less
82.32(n)
 
BX854059.1
zebrafish (Danio rerio)
Actinopterygii
wufj55b042
Transcribed sequence with weak similarity to protein refNP_492764.1 (C.elegans) F25H2.8.p [Caenorhabditis elegans] less
83.91(n)
 
BG306414.1
fruit fly (Drosophila melanogaster)
Insecta
CG45021
CG4502
66.87(n) 66.87(a)
 
34002 NM_135259.2 NP_609103.1
ENSEMBL Gene Tree for UBE2QL1 (if available)TreeFam Gene Tree for UBE2QL1 (if available)
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Paralogsfor UBE2QL1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for UBE2QL1 gene UBE2Q2 2 UBE2Q1 2 3 SIMAP similar genes for UBE2QL1 using alignment to 1 protein entry: U2QL1_HUMAN :GTAP UBE2Q1 UBE2Q2
UBE2QL1 for paralogs About GeneDecksing
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Genomic Variantsfor UBE2QL1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 5 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for UBE2QL1 (6448736 - 6495022 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for UBE2QL1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing UBE2QL1
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Disorders
/ Diseasesfor UBE2QL1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
UBE2QL1 for disorders About GeneDecksing 1 disease for UBE2QL1 : About MalaCards cri-du-chat syndrome Export disorders for UBE2QL1 gene to outside databases
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Publicationsfor UBE2QL1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for UBE2QL1 gene integrated from 9 sources : (articles sorted by number of sources associating them with UBE2QL1) Utopia : connect your pdf to the dynamic world of online information
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for UBE2QL1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing UBE2QL1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing UBE2QL1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing UBE2QL1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for UBE2QL1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for UBE2QL1 gene: Search GeneIP for patents involving UBE2QL1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor UBE2QL1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for UBE2QL1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for UBE2QL1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for UBE2QL1 OriGene Protein Over-expression Lysate for UBE2QL1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for UBE2QL1 OriGene 3'-UTR Clone for UBE2QL1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2QL1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2QL1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2QL1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing UBE2QL1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat UBE2QL1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat UBE2QL1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat UBE2QL1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat UBE2QL1
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UBE2QL1 Proteins, Antibodies, CLIAs, and ELISAs
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