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Aliases for UBE2Q2 Gene

Aliases for UBE2Q2 Gene

  • Ubiquitin Conjugating Enzyme E2 Q2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2Q Family Member 2 2
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 2 2
  • E2 Ubiquitin-Conjugating Enzyme Q2 4
  • Ubiquitin Carrier Protein Q2 4
  • Ubiquitin-Protein Ligase Q2 4
  • EC 61
  • EC 4

External Ids for UBE2Q2 Gene

Previous GeneCards Identifiers for UBE2Q2 Gene

  • GC15P073923
  • GC15P076135
  • GC15P052891

Summaries for UBE2Q2 Gene

GeneCards Summary for UBE2Q2 Gene

UBE2Q2 (Ubiquitin Conjugating Enzyme E2 Q2) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2Q1.

UniProtKB/Swiss-Prot for UBE2Q2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2Q2 Gene

Genomics for UBE2Q2 Gene

Regulatory Elements for UBE2Q2 Gene

Enhancers for UBE2Q2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F075901 1.2 ENCODE 6.8 +59.8 59768 3.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FBXO22 ENSG00000260274 ENSG00000203392 NRG4 SNX33 DNM1P49 LOC441728 LOC105370902 ENSG00000261232 DNM1P35
GH15F075842 1.1 ENCODE 7.4 +0.8 754 3.1 ATF1 CREB3L1 WRNIP1 SIN3A FEZF1 GLI4 DMAP1 ZNF2 YY1 GLIS2 MIR631 UBE2Q2 SCAMP5 LOC101929439 RN7SL510P
GH15F075867 0.5 Ensembl 12.8 +24.2 24217 1.0 ZFHX2 JUNB EGR2 FBXO22 UBE2Q2 RN7SL510P
GH15F075572 1.1 Ensembl ENCODE 5.5 -269.8 -269785 2.2 HDAC1 PKNOX1 NFRKB ZNF335 ZNF121 SCRT2 ZBTB11 CEBPB ZEB2 POLR2H MAN2C1 UBE2Q2 PTPN9 ENSG00000259931
GH15F075945 0.9 Ensembl ENCODE 6.2 +103.7 103717 2.1 PKNOX1 BHLHE40 SP2 PBX2 FOS MYC WT1 SP7 EGR2 NFE2L2 FBXO22 TMEM266 NRG4 UBE2Q2 MIR631 ENSG00000260685 FBXO22-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2Q2 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2Q2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001453938 515 2401 ATF1 CREB3L1 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 YY1 GLIS2 ELK1

Genomic Location for UBE2Q2 Gene

75,843,285 bp from pter
75,901,078 bp from pter
57,794 bases
Plus strand

Genomic View for UBE2Q2 Gene

Genes around UBE2Q2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2Q2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2Q2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Q2 Gene

Proteins for UBE2Q2 Gene

  • Protein details for UBE2Q2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q2
    Protein Accession:
    Secondary Accessions:
    • B7Z3Q2
    • H3BRG2
    • Q8N4G6
    • Q96J08

    Protein attributes for UBE2Q2 Gene

    375 amino acids
    Molecular mass:
    42818 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH34342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2Q2 Gene

    Alternative splice isoforms for UBE2Q2 Gene


neXtProt entry for UBE2Q2 Gene

Selected DME Specific Peptides for UBE2Q2 Gene


Post-translational modifications for UBE2Q2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UBE2Q2 Gene

Gene Families for UBE2Q2 Gene

Protein Domains for UBE2Q2 Gene

Suggested Antigen Peptide Sequences for UBE2Q2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family.
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Q2: view

Function for UBE2Q2 Gene

Molecular function for UBE2Q2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2Q2 Gene

Gene Ontology (GO) - Molecular Function for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0061631 ubiquitin conjugating enzyme activity IEA --
genes like me logo Genes that share ontologies with UBE2Q2: view
genes like me logo Genes that share phenotypes with UBE2Q2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2Q2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2Q2 Gene

Localization for UBE2Q2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Q2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2Q2 gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBE2Q2: view

Pathways & Interactions for UBE2Q2 Gene

genes like me logo Genes that share pathways with UBE2Q2: view

Pathways by source for UBE2Q2 Gene

UniProtKB/Swiss-Prot Q8WVN8-UB2Q2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0070936 protein K48-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2Q2: view

No data available for SIGNOR curated interactions for UBE2Q2 Gene

Drugs & Compounds for UBE2Q2 Gene

(3) Drugs for UBE2Q2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2Q2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with UBE2Q2: view

Transcripts for UBE2Q2 Gene

Unigene Clusters for UBE2Q2 Gene

Ubiquitin-conjugating enzyme E2Q family member 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for UBE2Q2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2Q2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2Q2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2Q2 Gene

This gene is overexpressed in Adipocyte (47.9) and CD8 Tcells (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2Q2 Gene

Protein tissue co-expression partners for UBE2Q2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2Q2 Gene:


SOURCE GeneReport for Unigene cluster for UBE2Q2 Gene:


mRNA Expression by UniProt/SwissProt for UBE2Q2 Gene:

Tissue specificity: Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor masses and invasive epithelium.
genes like me logo Genes that share expression patterns with UBE2Q2: view

No data available for mRNA differential expression in normal tissues for UBE2Q2 Gene

Orthologs for UBE2Q2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2Q2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UBE2Q2 34 35
  • 99.82 (n)
(Bos Taurus)
Mammalia UBE2Q2 34 35
  • 93.12 (n)
(Mus musculus)
Mammalia Ube2q2 34 16 35
  • 92.96 (n)
(Canis familiaris)
Mammalia UBE2Q2 34 35
  • 92.42 (n)
(Rattus norvegicus)
Mammalia Ube2q2 34
  • 90.43 (n)
(Monodelphis domestica)
Mammalia UBE2Q2 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2Q2 35
  • 71 (a)
(Gallus gallus)
Aves UBE2Q2 34 35
  • 82.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2q2 34
  • 77.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68587 34
(Danio rerio)
Actinopterygii ube2q2 35
  • 83 (a)
ube2q1 34 35
  • 69.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2924 34 35
  • 57.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001452 34
  • 57.29 (n)
(Caenorhabditis elegans)
Secernentea ubc-25 34 35
  • 55.28 (n)
Species where no ortholog for UBE2Q2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2Q2 Gene

Gene Tree for UBE2Q2 (if available)
Gene Tree for UBE2Q2 (if available)

Paralogs for UBE2Q2 Gene

Paralogs for UBE2Q2 Gene

(5) SIMAP similar genes for UBE2Q2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UBE2Q2: view

Variants for UBE2Q2 Gene

Sequence variations from dbSNP and Humsavar for UBE2Q2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10162820 -- 75,885,129(+) ttttt(A/T)atttg intron-variant
rs1020416 -- 75,864,275(-) TAAAC(C/T)AGATC intron-variant
rs1039547 -- 75,883,969(-) AGGCA(C/T)GTGGG intron-variant
rs10524276 -- 75,883,854(+) CACAC(-/ACACACACACAC)GTATA intron-variant
rs10651661 -- 75,900,572(+) TTAAC(-/AAG)AAATC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2Q2 Gene

Variant ID Type Subtype PubMed ID
nsv984093 CNV duplication 23825009
nsv976953 CNV duplication 23825009
nsv974601 CNV duplication 23825009
nsv1116463 OTHER inversion 24896259
nsv1044733 CNV loss 25217958
esv3636932 CNV loss 21293372
esv3636931 CNV loss 21293372
esv2749898 CNV deletion 23290073
esv2749895 CNV deletion 23290073
esv2659698 CNV deletion 23128226

Variation tolerance for UBE2Q2 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2Q2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2Q2 Gene

Disorders for UBE2Q2 Gene

Relevant External Links for UBE2Q2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBE2Q2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2Q2 Gene

Publications for UBE2Q2 Gene

  1. Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. (PMID: 16300736) Seghatoleslam A. … Wasylyk B. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 64
  2. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4 64
  3. Overexpression of the novel human gene, UBE2Q2, in breast cancer. (PMID: 20193842) Nikseresht M. … Owji A.A. (Cancer Genet. Cytogenet. 2010) 3 22 64
  4. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 46 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for UBE2Q2 Gene

Sources for UBE2Q2 Gene

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