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Aliases for UBE2Q2 Gene

Aliases for UBE2Q2 Gene

  • Ubiquitin Conjugating Enzyme E2 Q2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2Q Family Member 2 2
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 2 2
  • E2 Ubiquitin-Conjugating Enzyme Q2 4
  • Ubiquitin Carrier Protein Q2 4
  • Ubiquitin-Protein Ligase Q2 4
  • EC 6.3.2.19 56
  • EC 2.3.2.23 4

External Ids for UBE2Q2 Gene

Previous GeneCards Identifiers for UBE2Q2 Gene

  • GC15P073923
  • GC15P076135
  • GC15P052891

Summaries for UBE2Q2 Gene

GeneCards Summary for UBE2Q2 Gene

UBE2Q2 (Ubiquitin Conjugating Enzyme E2 Q2) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2Q1.

UniProtKB/Swiss-Prot for UBE2Q2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination.

Additional gene information for UBE2Q2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2Q2 Gene

Genomics for UBE2Q2 Gene

GeneHancer (GH) Regulatory Elements for UBE2Q2 Gene

Promoters and enhancers for UBE2Q2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I075842 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557.4 +0.8 753 3.1 SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 ZNF207 SP3 SP5 UBE2Q2 SIN3A ENSG00000260274 MAN2C1 COMMD4 FBXO22 MIR631 SCAMP5 LOC101929439 RN7SL510P
GH15I075022 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.8 -819.2 -819156 2.4 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ENSG00000260483 PPCDC SCAMP5 SIN3A CLK3 MAN2C1 ENSG00000260274 SNX33 ENSG00000203392 ISLR
GH15I074888 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.8 -952.7 -952656 4 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 MPI RPP25 SIN3A ENSG00000203392 SNX33 ISLR PTPN9 MAN2C1 PML SCAMP5
GH15I074841 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 9.8 -999.4 -999426 5 HDGF PKNOX1 SMAD1 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B ULK3 SIN3A RPP25 EDC3 ENSG00000260274 ENSG00000203392 MPI SCAMP2 MAN2C1 SNX33
GH15I075346 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 9.8 -494.2 -494172 5 HDGF ARID4B SIN3A ZNF2 ZNF213 ZNF143 KLF13 ZNF263 SP3 SP5 NEIL1 ENSG00000275645 ENSG00000260274 DNM1P35 EDC3 SIN3A MAN2C1 SNUPN FBXO22 LOC441728
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBE2Q2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2Q2 gene promoter:

Genomic Locations for UBE2Q2 Gene

Genomic Locations for UBE2Q2 Gene
chr15:75,843,285-75,901,078
(GRCh38/hg38)
Size:
57,794 bases
Orientation:
Plus strand
chr15:76,135,622-76,193,419
(GRCh37/hg19)

Genomic View for UBE2Q2 Gene

Genes around UBE2Q2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2Q2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2Q2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Q2 Gene

Proteins for UBE2Q2 Gene

  • Protein details for UBE2Q2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVN8-UB2Q2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q2
    Protein Accession:
    Q8WVN8
    Secondary Accessions:
    • B7Z3Q2
    • H3BRG2
    • Q8N4G6
    • Q96J08

    Protein attributes for UBE2Q2 Gene

    Size:
    375 amino acids
    Molecular mass:
    42818 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2Q2 Gene

    Alternative splice isoforms for UBE2Q2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2Q2 Gene

Selected DME Specific Peptides for UBE2Q2 Gene

Q8WVN8:
  • KSEDEGIEKENLAILEKIRK
  • LNGAVSGSVQA
  • DLQILKEKEG
  • GIYSVELINDSLYDWHVKL
  • PVLSGGYVLGGGA
  • DRLMKELRDIYRSQS
  • HCNITESYP
  • ATLVKGKARVQFGANK
  • ILLNFSFKDNFPFDPPFVRVV
  • CMELLTKQGWSSAYSIESVIMQI
  • EDLDHYEMKEEEP

Post-translational modifications for UBE2Q2 Gene

Domains & Families for UBE2Q2 Gene

Gene Families for UBE2Q2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for UBE2Q2 Gene

Suggested Antigen Peptide Sequences for UBE2Q2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVN8

UniProtKB/Swiss-Prot:

UB2Q2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Q2: view

Function for UBE2Q2 Gene

Molecular function for UBE2Q2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2Q2 Gene

Phenotypes From GWAS Catalog for UBE2Q2 Gene

Gene Ontology (GO) - Molecular Function for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2Q2: view
genes like me logo Genes that share phenotypes with UBE2Q2: view

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2Q2 Gene

Localization for UBE2Q2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Q2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2Q2 gene
Compartment Confidence
cytosol 5
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2Q2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UBE2Q2 Gene

Pathways & Interactions for UBE2Q2 Gene

genes like me logo Genes that share pathways with UBE2Q2: view

Pathways by source for UBE2Q2 Gene

UniProtKB/Swiss-Prot Q8WVN8-UB2Q2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination TAS --
GO:0070936 protein K48-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2Q2: view

No data available for SIGNOR curated interactions for UBE2Q2 Gene

Drugs & Compounds for UBE2Q2 Gene

(3) Drugs for UBE2Q2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for UBE2Q2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2Q2: view

Transcripts for UBE2Q2 Gene

Unigene Clusters for UBE2Q2 Gene

Ubiquitin-conjugating enzyme E2Q family member 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for UBE2Q2 Gene

GeneLoc Exon Structure for
UBE2Q2
ECgene alternative splicing isoforms for
UBE2Q2

Expression for UBE2Q2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2Q2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2Q2 Gene

This gene is overexpressed in Adipocyte (47.9) and CD8 Tcells (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2Q2 Gene



Protein tissue co-expression partners for UBE2Q2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2Q2 Gene:

UBE2Q2

SOURCE GeneReport for Unigene cluster for UBE2Q2 Gene:

Hs.23033

mRNA Expression by UniProt/SwissProt for UBE2Q2 Gene:

Q8WVN8-UB2Q2_HUMAN
Tissue specificity: Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor masses and invasive epithelium.

Evidence on tissue expression from TISSUES for UBE2Q2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with UBE2Q2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2Q2 Gene

Orthologs for UBE2Q2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2Q2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2Q2 33 34
  • 99.82 (n)
cow
(Bos Taurus)
Mammalia UBE2Q2 33 34
  • 93.12 (n)
mouse
(Mus musculus)
Mammalia Ube2q2 33 16 34
  • 92.96 (n)
dog
(Canis familiaris)
Mammalia UBE2Q2 33 34
  • 92.42 (n)
rat
(Rattus norvegicus)
Mammalia Ube2q2 33
  • 90.43 (n)
oppossum
(Monodelphis domestica)
Mammalia UBE2Q2 34
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2Q2 34
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2Q2 33 34
  • 82.7 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2q2 33
  • 77.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68587 33
zebrafish
(Danio rerio)
Actinopterygii ube2q2 34
  • 83 (a)
OneToMany
ube2q1 33 34
  • 69.94 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2924 33 34
  • 57.85 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001452 33
  • 57.29 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-25 33 34
  • 55.28 (n)
Species where no ortholog for UBE2Q2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2Q2 Gene

ENSEMBL:
Gene Tree for UBE2Q2 (if available)
TreeFam:
Gene Tree for UBE2Q2 (if available)

Paralogs for UBE2Q2 Gene

Paralogs for UBE2Q2 Gene

(5) SIMAP similar genes for UBE2Q2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UBE2Q2: view

Variants for UBE2Q2 Gene

Sequence variations from dbSNP and Humsavar for UBE2Q2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000096278 -- 75,890,291(+) T/C/G genic_downstream_transcript_variant, intron_variant
rs1000104889 -- 75,896,035(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000124475 -- 75,871,120(+) A/T intron_variant
rs1000147068 -- 75,882,870(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000177285 -- 75,870,906(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2Q2 Gene

Variant ID Type Subtype PubMed ID
esv2659698 CNV deletion 23128226
esv2749895 CNV deletion 23290073
esv2749898 CNV deletion 23290073
esv3636931 CNV loss 21293372
esv3636932 CNV loss 21293372
nsv1044733 CNV loss 25217958
nsv1116463 OTHER inversion 24896259
nsv974601 CNV duplication 23825009
nsv976953 CNV duplication 23825009
nsv984093 CNV duplication 23825009

Variation tolerance for UBE2Q2 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2Q2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2Q2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2Q2 Gene

Disorders for UBE2Q2 Gene

Additional Disease Information for UBE2Q2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UBE2Q2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2Q2 Gene

Publications for UBE2Q2 Gene

  1. Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. (PMID: 16300736) Seghatoleslam A … Wasylyk B (Biochemical and biophysical research communications 2006) 2 3 4 58
  2. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y … Navon A (The Journal of biological chemistry 2010) 3 4 58
  3. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) Köttgen A … Fox CS (Nature genetics 2010) 3 44 58
  4. Overexpression of the novel human gene, UBE2Q2, in breast cancer. (PMID: 20193842) Nikseresht M … Owji AA (Cancer genetics and cytogenetics 2010) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for UBE2Q2 Gene

Sources for UBE2Q2 Gene

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