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Aliases & Descriptions for UBE2Q2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DKFZp762C143 1 , 2 EC 6.3.2.19 3
Descriptions Ubiquitin carrier protein Q2 2 , 3 Ubiquitin-protein ligase Q2 2 , 3 ubiquitin-conjugating enzyme E2Q (putative) 2 1 ubiquitin-conjugating enzyme E2Q 2 2 ubiquitin-conjugating enzyme E2Q family member 2 2
Search outside databases for aliases for UBE2Q2 gene
Summaries for UBE2Q2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8 Function : Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
Genomic Location for UBE2Q2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the UBE2Q2 gene Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q24.2 UBE2Q2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P073923:
(about GC identifiers )
Start:
73,922,855 bp from pter
End:
73,980,440 bp from pter
Size:
57,586 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000015.8 NT_010194.16 Proteins for UBE2Q2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8 (See
protein sequence )Recommended Name: Ubiquitin-conjugating enzyme E2 Q2 Size : 375 amino acids; 42818 Da
Subcellular location : Cytoplasm
PDB structures from and Proteopedia : 1ZUO (3D)
 
Secondary accessions : Q8N4G6 Q96J08Alternative splicing : 2 isoforms : Q8WVN8-1 Q8WVN8-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001138807.1 NP_775740.1 ENSEMBL proteins: ENSP00000267938 ENSP00000340187 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005737 cytoplasm
IEA --
About this table Antibodies for UBE2Q2: Assays for UBE2Q2:
Protein
Domains/ Families for UBE2Q2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8WVN8 ProtoNet protein and cluster: Q8WVN8
2 Blocks protein families : IPB000608 Ubiquitin-conjugating enzymes IPB006575 RWD UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8 Similarity : Belongs to the ubiquitin-conjugating enzyme family
Gene Function for UBE2Q2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_173469 Applied Biosystems Silencer ® siRNAs for UBE2Q2 Sigma-Aldrich siRNA and siRNA Panels for UBE2Q2 Sigma-Aldrich shRNA Panels and shRNA for UBE2Q2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145335                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145335                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001145335  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_173469 UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8 Function : Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)Catalytic activity : ATP + ubiquitin + protein lysine = AMP + diphosphate + proteinN-ubiquityllysine Enzyme Number (IUBMB): EC 6.3.2.19
4 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for UBE2Q2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8 Pathway : Protein modification; protein ubiquitination
1 Interacting protein for UBE2Q2 (ENSP00000267938 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0019941 modification-dependent protein catabolic process
IEA -- GO:0043687 post-translational protein modification
IEA -- GO:0051246 regulation of protein metabolic process
IEA --
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Drugs & Compounds for UBE2Q2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for UBE2Q2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_173469 Sigma-Aldrich siRNA and siRNA Panels for UBE2Q2 Sigma-Aldrich shRNA Panels and shRNA for UBE2Q2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_173469
REFSEQ mRNAs for UBE2Q2 gene (2 alternative transcripts): NM_001145335.1 NM_173469.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_173469
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145335                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145335                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001145335  
Additional cDNA sequence: AK000617.1 AK294199.1 AK296234.1 AL117641.1 AL832429.1 BC006827.1 BC017708.1 BC034342.1 CR619639.1
10 DOTS entries : DT.451580 DT.95124051 DT.95178694 DT.92440861 DT.121037480 DT.121037494 DT.121037505 DT.92440868 DT.95124041 DT.95291218
24/421 AceView cDNA sequences (see all 421
):BC041691 AI889593 CR608996 AI811582 AI283601 AL531788 AA135739 AI476451 AK026282 BU164363 AW615175 AA614813 CA438075 NM_147188 AI821796 AA609550 CA774792 CA421878 BM449628 CD242902 AW182899 BM712566 BQ632728 BG565427
highest scoring ESTs for UBE2Q2 :AA044199 AA044996 AA135739 AA135782 AA146912 AA173589 AA224431 AA232224 AA233868 AA256599
Unigene Cluster for UBE2Q2: Ubiquitin-conjugating enzyme E2Q family member 2 Hs.23033 [show with all ESTs ] Unigene Representative Sequence: NM_173469 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q2 ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 SP1 :   -   -                           SP2 :   -   -     -                       SP3 :     -                           SP4 :                              
About this scheme ECgene alternative splicing isoforms for UBE2Q2 2 Ensembl transcripts including schematic representations : ENST00000267938
ENST00000338677
Expression for UBE2Q2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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UBE2Q2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for UBE2Q2 1 / 2 / 3
2 probe-sets matching UBE2Q2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.23033 UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8 Tissue specificity : Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumormasses and invasive epithelium
Orthologs for UBE2Q2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for UBE2Q2 gene from 5/12 species (see all 12
)
About this table Species with no ortholog for UBE2Q2 ENSEMBL Gene Tree for UBE2Q2 Paralogs for UBE2Q2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for UBE2Q2 gene ENSG00000189136 2 ENSG00000215218 2 UBE2Q1 2
SNPs/Variants for UBE2Q2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for UBE2Q2 (up to first 250kb)
Disorders & Mutations for UBE2Q2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 612501
Medical News for UBE2Q2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for UBE2Q2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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6 PubMed articles for UBE2Q2 gene :
Search for UBE2Q2
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing UBE2Q2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing UBE2Q2
(According to HUGE )
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--
Specialized Databases showing UBE2Q2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for UBE2Q2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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