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UBE2Q2 Gene

protein-coding   GIFtS: 49

GC15P073923
ubiquitin-conjugating enzyme E2Q family member 2
(Previous name: ubiquitin-conjugating enzyme E2Q (putative) 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DKFZp762C143 1, 2
EC 6.3.2.19 3
Descriptions
Ubiquitin carrier protein Q2 2, 3
Ubiquitin-protein ligase Q2 2, 3
ubiquitin-conjugating enzyme E2Q (putative) 2 1
ubiquitin-conjugating enzyme E2Q 2 2
ubiquitin-conjugating enzyme E2Q family member 2 2
External Ids
HGNC: 192481
Entrez Gene: 929122
UniProtKB: Q8WVN83
Ensembl: ENSG000001403677
Search outside databases for aliases for UBE2Q2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the UBE2Q2 gene  

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q24.2

UBE2Q2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P073923:     (about GC identifiers)

Start:
73,922,855 bp from pter
End:
73,980,440 bp from pter
Size:
57,586 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 Q2  
Size: 375 amino acids; 42818 Da
Subcellular location: Cytoplasm
PDB structures from and Proteopedia :
1ZUO (3D)    
Secondary accessions: Q8N4G6 Q96J08
Alternative splicing: 2 isoforms:  Q8WVN8-1   Q8WVN8-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001138807.1  NP_775740.1  


    ENSEMBL proteins: 
    ENSP00000267938 ENSP00000340187 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (UBE2Q2)
    Human Recombinant Proteins from Abnova (UBE2Q2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for UBE2Q2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for UBE2Q2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (UBE2Q2), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (UBE2Q2)
    Novus Biologicals Antibodies for UBE2Q2

    Assays for UBE2Q2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR000608 UBQ-conjugat_E2
     IPR006575 RWD
     IPR016135 UBQ-conjugat/RWD-like


       GeneDecks  UBE2Q2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8WVN8

    ProtoNet protein and cluster: Q8WVN8

    2 Blocks protein families:
    IPB000608 Ubiquitin-conjugating enzymes
    IPB006575 RWD


    UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
    Similarity: Belongs to the ubiquitin-conjugating enzyme family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBE2Q2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (UBE2Q2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_173469

                  Applied Biosystems Silencer® siRNAs for UBE2Q2

                  Sigma-Aldrich siRNA and siRNA Panels for UBE2Q2  
                         Sigma-Aldrich shRNA Panels and shRNA for UBE2Q2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for UBE2Q2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145335
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145335
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145335 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_173469

    UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein
    N-ubiquityllysine
    Enzyme Number (IUBMB): EC 6.3.2.19 

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004842 ubiquitin-protein ligase activity IEA--
    GO:0005524 ATP binding IEA--
    GO:0016874 ligase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for UBE2Q2):
     hsa04120 Ubiquitin mediated proteolysis

       GeneDecks  UBE2Q2 for the pathways selected above  
    About GeneDecksing
    UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
    Pathway: Protein modification; protein ubiquitination


    1 Interacting protein for UBE2Q2 (ENSP000002679383) via UniProtKB, MINT, and/or STRING

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448183STRING (score=.918)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019941 modification-dependent protein catabolic process IEA--
    GO:0043687 post-translational protein modification IEA--
    GO:0051246 regulation of protein metabolic process IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for UBE2Q2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBE2Q2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (UBE2Q2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_173469

                  Sigma-Aldrich siRNA and siRNA Panels for UBE2Q2  
                         Sigma-Aldrich shRNA Panels and shRNA for UBE2Q2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_173469  

    REFSEQ mRNAs for UBE2Q2 gene (2 alternative transcripts): 

    NM_001145335.1   NM_173469.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_173469  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145335
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145335
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145335 

    Additional cDNA sequence: 

    AK000617.1 AK294199.1 AK296234.1 AL117641.1 AL832429.1 BC006827.1 BC017708.1 BC034342.1 
    CR619639.1 

    10 DOTS entries:

    DT.451580  DT.95124051  DT.95178694  DT.92440861  DT.121037480  DT.121037494  DT.121037505  DT.92440868 
    DT.95124041  DT.95291218 

    24/421 AceView cDNA sequences (see all 421 ):

    BC041691 AI889593 CR608996 AI811582 AI283601 AL531788 AA135739 AI476451 
    AK026282 BU164363 AW615175 AA614813 CA438075 NM_147188 AI821796 AA609550 
    CA774792 CA421878 BM449628 CD242902 AW182899 BM712566 BQ632728 BG565427 

    highest scoring ESTs for UBE2Q2:

    AA044199 AA044996 AA135739 AA135782 AA146912 AA173589 AA224431 AA232224 AA233868 AA256599 

    Unigene Cluster for UBE2Q2:

    Ubiquitin-conjugating enzyme E2Q family member 2
    Hs.23033  [show with all ESTs]
    Unigene Representative Sequence: NM_173469


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q2

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:        -     -                                                                           
    SP2:        -     -           -                                                               
    SP3:              -                                                                           
    SP4:                                                                                          

    About this scheme

    ECgene alternative splicing isoforms for UBE2Q2

    2 Ensembl transcripts including schematic representations:
    ENST00000267938  ENST00000338677  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    UBE2Q2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for UBE2Q2

    1 / 2 / 3

    2 probe-sets matching UBE2Q2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    224747_at2, 3 U133-B 1 1.00 1.00 -- -- AK000617 0.80 1.00 0.91 1

    224747_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.23033

    UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
    Tissue specificity: Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor
    masses and invasive epithelium

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for UBE2Q2 gene from 5/12 species (see all 12 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    UBE2Q21   -- ubiquitin-conjugating enzyme E2Q family member 2 95.97(n)
    98.09(a)
    478374  XM_535548.2  XP_535548.2 
    chimpanzee
    (Pan troglodytes)
    UBE2Q21   -- ubiquitin-conjugating enzyme E2Q family member 2 99.82(n)
    99.73(a)
    453772  XM_001145531.1  XP_001145531.1 
    cow
    (Bos taurus)
    UBE2Q21   -- ubiquitin-conjugating enzyme E2Q family member 2 95.18(n)
    98.53(a)
    511631  NM_001075530.1  NP_001068998.1 
    mouse
    (Mus musculus)
    Ube2q21, 5 95
    ubiquitin-conjugating enzyme E2Q (putative) 21, 5 94.03(n)1
    95.72(a)1
    1091611  NM_180600.21  NP_850931.11 
     AA8804865  AK0425155  (see all 12)
    chicken
    (Gallus gallus)
    UBE2Q21   -- ubiquitin-conjugating enzyme E2Q family member 2 83.86(n)
    91.4(a)
    415356  XM_413740.2  XP_413740.2 
    About this table        Species with no ortholog for UBE2Q2

    ENSEMBL Gene Tree for UBE2Q2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for UBE2Q2 gene
    ENSG000001891362  ENSG000002152182  UBE2Q12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/303 NCBI SNPs in UBE2Q2 are shown (see all 303 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 79)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs3356871,2
    A,C,F,H,O73979021(-) AATGCG/AAAGGC 1 -- ut31 ese311Minor allele frequency- A:0.04EA NA MN EU WA 796
    rs81820371,2
    A,C,F,H73921656(+) ACTTAC/TGATTG 1 -- ng5117Minor allele frequency- N:0.00EU EA WA NS NA 1164
    rs3356891,2
    C,F,H,O73978857(-) CAACAT/CATTTA 1 -- ut318Minor allele frequency- C:0.02MN EU EA WA NA 724
    rs3356881,2
    C,F,H73978907(-) ATGTTG/AGAAAG 1 -- ut315Minor allele frequency- A:0.01MN EU EA WA 602
    rs174275481,2
    C,F,H73979484(+) TATCAA/GTTAAG 1 -- ut3111Minor allele frequency- G:0.02NA EU EA WA 980
    --
    rs23077921,2
    F73979970(-) TGGATTTC/-TTGTT 1 -- ut314Minor allele frequency- -:0.07EU NA EA 342
    --
    rs81820131,2
    C73921513(+) aaaatA/Gcggag 1 -- ng51 tfbs30--------
    rs19767481,2
    A,C,F,H,O73948006(+) AAGCCA/GTTGAT 1 -- int18Minor allele frequency- N:0.01EU EA WA NA 630
    rs24608011,2
    A,C,F,H,O73951403(-) TTCCTT/CACAAT 1 -- int16Minor allele frequency- C:0.03EU EA NA 438
    rs25932801,2
    C,F,H,O73938020(+) GGAGAA/GTGTAC 1 -- int111Minor allele frequency- G:0.18NA EU EA WA 962
    About this table

    HapMap Linkage Disequilibrium images for UBE2Q2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 612501

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    6 PubMed articles for UBE2Q2 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 92912 HGNC: 19248 AceView: FBXO22 Ensembl:ENSG00000140367 euGenes: HUgn92912
    ECgene: UBE2Q2 H-InvDB: UBE2Q2
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for UBE2Q2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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     Predesigned and custom siRNAs for UBE2Q2 Antibodies for UBE2Q2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for UBE2Q2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Antibodies for UBE2Q2

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