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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2Q2 Gene

protein-coding   GIFtS: 57
GCID: GC15P076135

Ubiquitin-Conjugating Enzyme E2Q Family Member 2

(Previous name: ubiquitin-conjugating enzyme E2Q (putative) 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2Q Family Member 21 2     Ubiquitin-Conjugating Enzyme E2Q (Putative) 21
Ubiquitin Carrier Protein Q22 3     Ubiquitin-Conjugating Enzyme E2 Q22
Ubiquitin-Protein Ligase Q22 3     LOC929125
EC 6.3.2.193 8     

External Ids:    HGNC: 192481   Entrez Gene: 929122   Ensembl: ENSG000001403677   OMIM: 6125015   UniProtKB: Q8WVN83   

Export aliases for UBE2Q2 gene to outside databases

Previous GC identifers: GC15P073923 GC15P052891


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBE2Q2 Gene: 
UBE2Q2 (ubiquitin-conjugating enzyme E2Q family member 2) is a protein-coding gene. Diseases associated with UBE2Q2 include kidney disease, and acute lymphoblastic leukemia, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is UBE2QL1.

UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-48'-linked polyubiquitination




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2Q2 gene promoter:
         AREB6   c-Fos   AP-1   JunD   FosB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2Q2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2Q2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2Q2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q24.2

UBE2Q2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2Q2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P076135:  view genomic region     (about GC identifiers)

Start:
76,135,622 bp from pter      End:
76,193,419 bp from pter
Size:
57,798 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 Q2  
Size: 375 amino acids; 42818 Da
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAH34342.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for UBE2Q2:
1ZUO (3D)    
Secondary accessions: B7Z3Q2 H3BRG2 Q8N4G6 Q96J08
Alternative splicing: 3 isoforms:  Q8WVN8-1   Q8WVN8-2   Q8WVN8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2Q2: NX_Q8WVN8

Explore proteomics data for UBE2Q2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WVN8

  • 4/11 DME Specific Peptides for UBE2Q2 (Q8WVN8) (see all 11)
     HCNITESYP  DLQILKEKEG  LNGAVSGSVQA  EDLDHYEMKEEEP 

    UBE2Q2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2Q2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001138807.1  NP_001271311.1  NP_775740.1  

    ENSEMBL proteins: 
     ENSP00000267938   ENSP00000456324   ENSP00000458006   ENSP00000456229   ENSP00000400960  
     ENSP00000454742   ENSP00000340187  
    Reactome Protein details: Q8WVN8
    Human Recombinant Protein Products for UBE2Q2: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for UBE2Q2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    UBE2Q2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR000608 UBQ-conjugat_E2
     IPR006575 RWD-domain

    Graphical View of Domain Structure for InterPro Entry Q8WVN8

    ProtoNet protein and cluster: Q8WVN8

    2 Blocks protein domains:
    IPB000608 Ubiquitin-conjugating enzymes
    IPB006575 RWD


    UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2Q2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2Q2_HUMAN, Q8WVN8
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-48'-linked polyubiquitination
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2Q2 for ontologies           About GeneDecksing


    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidUBE2Q2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2Q2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for UBE2Q2
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE2Q2):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
    Pathway: Protein modification; protein ubiquitination


    UBE2Q2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2Q2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for UBE2Q2 (Q8WVN83 ENSP000002679384) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    AK6Q165943I2D: score=1 
    BIRC3Q134893, ENSP000002634644I2D: score=1 STRING: ENSP00000263464
    EXOSC7Q150243, ENSP000002655644I2D: score=1 STRING: ENSP00000265564
    MGRN1O602913, ENSP000002623704I2D: score=1 STRING: ENSP00000262370
    TAF9Q165943I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070936protein K48-linked ubiquitination IDA--

    UBE2Q2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2Q2 (UB2Q2)

    4 HMDB Compounds for UBE2Q2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2Q2 / UB2Q2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2Q2 gene (3 alternative transcripts): 
    NM_001145335.1  NM_001284382.1  NM_173469.3  

    Unigene Cluster for UBE2Q2:

    Ubiquitin-conjugating enzyme E2Q family member 2
    Hs.23033  [show with all ESTs]
    Unigene Representative Sequence: NM_173469
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267938(uc002bbg.2 uc002bbh.2 uc010umn.1 uc002bbi.2)
    ENST00000569423 ENST00000561723 ENST00000561851 ENST00000562635 ENST00000426727
    ENST00000567921 ENST00000563966 ENST00000338677
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidUBE2Q2 3' UTR sequence
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    Additional mRNA sequence: 

    AK000617.1 AK294199.1 AK296234.1 AL117641.1 AL832429.1 BC006827.1 BC017708.1 BC034342.1 

    10 DOTS entries:

    DT.451580  DT.95124051  DT.95178694  DT.92440861  DT.121037480  DT.121037494  DT.121037505  DT.92440868 
    DT.95124041  DT.95291218 

    24/421 AceView cDNA sequences (see all 421):

    AI754283 AA173736 AW163504 AI124947 BC039024 BE220885 F08286 BM552234 
    AA243127 BU164363 AI952602 BQ632728 AW182899 BM923907 AI148292 NM_147188 
    AA614813 AU132133 AL705237 Z41297 AI183667 BE327073 AI889593 BX102264 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q2    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
    SP1:        -     -                                                                           
    SP2:        -     -           -                                                               
    SP3:              -                                                                           
    SP4:                                                                                          


    ECgene alternative splicing isoforms for UBE2Q2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2Q2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGTTTAA
    UBE2Q2 Expression
    About this image


    See UBE2Q2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2Q2

    SOURCE GeneReport for Unigene cluster: Hs.23033

    UniProtKB/Swiss-Prot: UB2Q2_HUMAN, Q8WVN8
    Tissue specificity: Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor masses and invasive
    epithelium

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBE2Q2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2q21 , 5 ubiquitin-conjugating enzyme E2Q (putative) 21, 5 94.12(n)1
    95.99(a)1
      9 (29.84 cM)5
    1091611  NM_180600.31  NP_850931.21 
     551488545 
    chicken
    (Gallus gallus)
    Aves UBE2Q21 ubiquitin-conjugating enzyme E2Q family member 2 83.86(n)
    91.4(a)
      415356  XM_413740.3  XP_413740.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685872 hypothetical protein MGC68587 79.92(n)    BC060407.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CF996948.12   -- 75.03(n)    CF996948.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29241 CG2924 59.26(n)
    58.61(a)
      31214  NM_166935.2  NP_726805.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-251 Protein UBC-25 55.46(n)
    49.44(a)
      172941  NM_060363.2  NP_492764.2 


    ENSEMBL Gene Tree for UBE2Q2 (if available)
    TreeFam Gene Tree for UBE2Q2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2Q2 gene
    UBE2QL12  UBE2Q12  
    4 SIMAP similar genes for UBE2Q2 using alignment to 6 protein entries:     UB2Q2_HUMAN (see all proteins):
    LOC100505679    UBE2Q1    GTAP    UBE2QL1

    UBE2Q2 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for UBE2Q2 (see all 7)
    PGOHUM00000262233 PGOHUM00000262260 PGOHUM00000262262 PGOHUM00000262434 PGOHUM00000250012


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1157 SNPs in UBE2Q2 are shown (see all 1157)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs287208741,2
    C,F--76133633(+) TTCTGA/GGATAC 1 -- us2k110Minor allele frequency- G:0.27NA WA CSA EA 370
    rs1882815511,2
    --76133673(+) GCTCTA/GTTTTC 1 -- us2k10--------
    rs1930485181,2
    --76134014(+) AAGTAC/GAAAAT 1 -- us2k10--------
    rs1461881471,2
    C--76134174(+) GCTGG-/TTTTGA 1 -- us2k10--------
    rs1388552291,2
    --76134203(+) TGTAGA/GCTGTG 1 -- us2k10--------
    rs1493193031,2
    --76134321(+) TTCAGC/TAGACT 1 -- us2k10--------
    rs1445817911,2
    --76134345(+) TGTTGC/TTCTGT 1 -- us2k10--------
    rs1151076371,2
    C--76134444(+) AAGACT/CGGAAA 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs81820131,2
    C,F--76134458(+) AAAATG/ACGGAG 2 -- us2k1 tfbs34Minor allele frequency- A:0.31NA EA 244
    rs604966081,2
    C,F--76134544(+) GGGAGC/AACTGT 2 -- us2k13Minor allele frequency- A:0.17WA CSA 122

    HapMap Linkage Disequilibrium report for UBE2Q2 (76135622 - 76193419 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UBE2Q2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749895CNV Deletion23290073
    esv2659698CNV Deletion23128226
    esv2749898CNV Deletion23290073
    esv271401CNV Insertion20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612501    OMIM disorders: --

    5 diseases for UBE2Q2:    About MalaCards
    kidney disease    acute lymphoblastic leukemia    lymphoblastic leukemia    squamous cell carcinoma
    leukemia


    UBE2Q2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBE2Q2
    Human Genome Epidemiology (HuGE) Navigator: UBE2Q2 (1 document)

    Export disorders for UBE2Q2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2Q2 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with UBE2Q2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. (PubMed id 16300736)1, 2, 3 Seghatoleslam A.... Wasylyk B. (2006)
    2. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Overexpression of the novel human gene, UBE2Q2, in br east cancer. (PubMed id 20193842)1, 9 Nikseresht M....Owji A.A. (2010)
    5. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 Kottgen A....Gieger C. (2013)
    6. Expression of UBE2Q2, a putative member of the ubiquit in-conjugating enzyme family in pediatric acute lymphoblastic leukemia. (PubMed id 22642244)1 Seghatoleslam A....Owji A.A. (2012)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. c-IAP1 and UbcH5 promote K11-linked polyubiquitinatio n of RIP1 in TNF signalling. (PubMed id 21113135)1 Dynek J.N....Vucic D. (2010)
    9. The E2 ubiquitin-conjugating enzymes direct polyubiqu itination to preferred lysines. (PubMed id 20061386)2 David Y....Navon A. (2010)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92912 HGNC: 19248 AceView: FBXO22 Ensembl:ENSG00000140367 euGenes: HUgn92912
    ECgene: UBE2Q2 Kegg: 92912 H-InvDB: UBE2Q2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2Q2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2Q2 gene:
    Search GeneIP for patents involving UBE2Q2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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