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Aliases for UBE2Q2 Gene

Aliases for UBE2Q2 Gene

  • Ubiquitin Conjugating Enzyme E2 Q2 2 3
  • Ubiquitin-Conjugating Enzyme E2Q Family Member 2 2
  • Ubiquitin Conjugating Enzyme E2Q Family Member 2 5
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 2 2
  • E2 Ubiquitin-Conjugating Enzyme Q2 4
  • Ubiquitin Carrier Protein Q2 4
  • Ubiquitin-Protein Ligase Q2 4
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4

External Ids for UBE2Q2 Gene

Previous GeneCards Identifiers for UBE2Q2 Gene

  • GC15P073923
  • GC15P076135
  • GC15P052891

Summaries for UBE2Q2 Gene

GeneCards Summary for UBE2Q2 Gene

UBE2Q2 (Ubiquitin Conjugating Enzyme E2 Q2) is a Protein Coding gene. Diseases associated with UBE2Q2 include squamous cell carcinoma, head and neck. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2Q1.

UniProtKB/Swiss-Prot for UBE2Q2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2Q2 Gene

Genomics for UBE2Q2 Gene

Regulatory Elements for UBE2Q2 Gene

Promoters for UBE2Q2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2Q2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2Q2 Gene

Chromosome:
15
Start:
75,843,285 bp from pter
End:
75,901,078 bp from pter
Size:
57,794 bases
Orientation:
Plus strand

Genomic View for UBE2Q2 Gene

Genes around UBE2Q2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2Q2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2Q2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Q2 Gene

Proteins for UBE2Q2 Gene

  • Protein details for UBE2Q2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVN8-UB2Q2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q2
    Protein Accession:
    Q8WVN8
    Secondary Accessions:
    • B7Z3Q2
    • H3BRG2
    • Q8N4G6
    • Q96J08

    Protein attributes for UBE2Q2 Gene

    Size:
    375 amino acids
    Molecular mass:
    42818 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2Q2 Gene

    Alternative splice isoforms for UBE2Q2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2Q2 Gene

Proteomics data for UBE2Q2 Gene at MOPED

Post-translational modifications for UBE2Q2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2Q2 Gene

Antibody Products

Domains & Families for UBE2Q2 Gene

Gene Families for UBE2Q2 Gene

Protein Domains for UBE2Q2 Gene

Suggested Antigen Peptide Sequences for UBE2Q2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVN8

UniProtKB/Swiss-Prot:

UB2Q2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Q2: view

Function for UBE2Q2 Gene

Molecular function for UBE2Q2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2Q2 Gene

Gene Ontology (GO) - Molecular Function for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with UBE2Q2: view
genes like me logo Genes that share phenotypes with UBE2Q2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2Q2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2Q2 Gene

Localization for UBE2Q2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Q2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2Q2 Gene COMPARTMENTS Subcellular localization image for UBE2Q2 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for UBE2Q2 Gene

Pathways & Interactions for UBE2Q2 Gene

genes like me logo Genes that share pathways with UBE2Q2: view

Pathways by source for UBE2Q2 Gene

UniProtKB/Swiss-Prot Q8WVN8-UB2Q2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Q2 Gene

None

No data available for SIGNOR curated interactions for UBE2Q2 Gene

Drugs & Compounds for UBE2Q2 Gene

(3) Drugs for UBE2Q2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2Q2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2Q2: view

Transcripts for UBE2Q2 Gene

Unigene Clusters for UBE2Q2 Gene

Ubiquitin-conjugating enzyme E2Q family member 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for UBE2Q2 Gene

GeneLoc Exon Structure for
UBE2Q2
ECgene alternative splicing isoforms for
UBE2Q2

Expression for UBE2Q2 Gene

mRNA expression in normal human tissues for UBE2Q2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2Q2 Gene

This gene is overexpressed in Adipocyte (47.9) and CD8 Tcells (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2Q2 Gene



SOURCE GeneReport for Unigene cluster for UBE2Q2 Gene Hs.23033

mRNA Expression by UniProt/SwissProt for UBE2Q2 Gene

Q8WVN8-UB2Q2_HUMAN
Tissue specificity: Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor masses and invasive epithelium.
genes like me logo Genes that share expression patterns with UBE2Q2: view

Protein tissue co-expression partners for UBE2Q2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE2Q2 Gene

Orthologs for UBE2Q2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2Q2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2Q2 36
  • 100 (a)
OneToOne
UBE2Q2 35
  • 99.82 (n)
  • 99.73 (a)
cow
(Bos Taurus)
Mammalia UBE2Q2 35
  • 93.12 (n)
  • 95.87 (a)
UBE2Q2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2Q2 36
  • 92 (a)
OneToOne
UBE2Q2 35
  • 92.42 (n)
  • 91.98 (a)
mouse
(Mus musculus)
Mammalia Ube2q2 16
Ube2q2 36
  • 93 (a)
OneToOne
Ube2q2 35
  • 92.96 (n)
  • 94.39 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2Q2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2Q2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2q2 35
  • 90.43 (n)
  • 92.01 (a)
chicken
(Gallus gallus)
Aves UBE2Q2 35
  • 82.7 (n)
  • 89.81 (a)
UBE2Q2 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68587 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2q2 35
  • 77.57 (n)
  • 87.19 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2q1 36
  • 82 (a)
OneToMany
ube2q2 36
  • 83 (a)
OneToMany
ube2q1 35
  • 69.94 (n)
  • 78.04 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001452 35
  • 57.29 (n)
  • 54.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2924 36
  • 51 (a)
OneToMany
CG2924 35
  • 57.85 (n)
  • 57.02 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-25 35
  • 55.28 (n)
  • 48.06 (a)
ubc-25 36
  • 44 (a)
OneToMany
Species with no ortholog for UBE2Q2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2Q2 Gene

ENSEMBL:
Gene Tree for UBE2Q2 (if available)
TreeFam:
Gene Tree for UBE2Q2 (if available)

Paralogs for UBE2Q2 Gene

Paralogs for UBE2Q2 Gene

(5) SIMAP similar genes for UBE2Q2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UBE2Q2: view

Variants for UBE2Q2 Gene

Sequence variations from dbSNP and Humsavar for UBE2Q2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs335687 -- 75,899,625(-) AATGC(A/G)AAGGC utr-variant-3-prime
rs335688 -- 75,899,511(-) ATGTT(A/G)GAAAG utr-variant-3-prime
rs335712 -- 75,891,538(-) ACCTA(C/T)TTTTT intron-variant
rs335713 -- 75,890,608(-) TAGAC(A/G)CTATT intron-variant
rs335714 -- 75,890,255(-) TATCA(C/T)GCTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2Q2 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
esv271401 CNV Insertion 20981092
esv2659698 CNV Deletion 23128226

Variation tolerance for UBE2Q2 Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2Q2 Gene

HapMap Linkage Disequilibrium report
UBE2Q2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2Q2 Gene

Disorders for UBE2Q2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBE2Q2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
squamous cell carcinoma, head and neck
  • squamous cell carcinoma, head and neck, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UBE2Q2

Genetic Association Database (GAD)
UBE2Q2
Human Genome Epidemiology (HuGE) Navigator
UBE2Q2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2Q2
genes like me logo Genes that share disorders with UBE2Q2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2Q2 Gene

Publications for UBE2Q2 Gene

  1. Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. (PMID: 16300736) Seghatoleslam A. … Wasylyk B. (Biochem. Biophys. Res. Commun. 2006) 2 3 4 67
  2. Overexpression of the novel human gene, UBE2Q2, in breast cancer. (PMID: 20193842) Nikseresht M. … Owji A.A. (Cancer Genet. Cytogenet. 2010) 3 23
  3. Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. (PMID: 25527291) Wauer T. … Komander D. (EMBO J. 2015) 3
  4. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3
  5. Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia. (PMID: 22642244) Seghatoleslam A. … Owji A.A. (Arch Iran Med 2012) 3

Products for UBE2Q2 Gene

Sources for UBE2Q2 Gene

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