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Aliases for UBE2Q2 Gene

Aliases for UBE2Q2 Gene

  • Ubiquitin-Conjugating Enzyme E2Q Family Member 2 2 3
  • EC 6.3.2.19 4 63
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 2 2
  • Ubiquitin Carrier Protein Q2 4
  • Ubiquitin-Protein Ligase Q2 4
  • LOC92912 6

External Ids for UBE2Q2 Gene

Previous GeneCards Identifiers for UBE2Q2 Gene

  • GC15P073923
  • GC15P076135
  • GC15P052891

Summaries for UBE2Q2 Gene

GeneCards Summary for UBE2Q2 Gene

UBE2Q2 (Ubiquitin-Conjugating Enzyme E2Q Family Member 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2Q1.

UniProtKB/Swiss-Prot for UBE2Q2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2Q2 Gene

Genomics for UBE2Q2 Gene

Regulatory Elements for UBE2Q2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2Q2 Gene

Start:
75,843,285 bp from pter
End:
75,901,078 bp from pter
Size:
57,794 bases
Orientation:
Plus strand

Genomic View for UBE2Q2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2Q2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Q2 Gene

Proteins for UBE2Q2 Gene

  • Protein details for UBE2Q2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVN8-UB2Q2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q2
    Protein Accession:
    Q8WVN8
    Secondary Accessions:
    • B7Z3Q2
    • H3BRG2
    • Q8N4G6
    • Q96J08

    Protein attributes for UBE2Q2 Gene

    Size:
    375 amino acids
    Molecular mass:
    42818 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH34342.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2Q2 Gene

    Alternative splice isoforms for UBE2Q2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2Q2 Gene

Proteomics data for UBE2Q2 Gene at MOPED

Post-translational modifications for UBE2Q2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2Q2 Gene

Domains for UBE2Q2 Gene

Gene Families for UBE2Q2 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2Q2 Gene

Suggested Antigen Peptide Sequences for UBE2Q2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVN8

UniProtKB/Swiss-Prot:

UB2Q2_HUMAN :
  • Q8WVN8
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Q2: view

Function for UBE2Q2 Gene

Molecular function for UBE2Q2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2Q2 Gene

Gene Ontology (GO) - Molecular Function for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2Q2: view

Animal Model Products

CRISPR Products

miRNA for UBE2Q2 Gene

miRTarBase miRNAs that target UBE2Q2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2Q2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2Q2 Gene

Localization for UBE2Q2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Q2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2Q2 Gene COMPARTMENTS Subcellular localization image for UBE2Q2 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBE2Q2: view

Pathways for UBE2Q2 Gene

genes like me logo Genes that share pathways with UBE2Q2: view

UniProtKB/Swiss-Prot Q8WVN8-UB2Q2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Q2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070936 protein K48-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2Q2: view

Compounds for UBE2Q2 Gene

(4) HMDB Compounds for UBE2Q2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2Q2: view

Transcripts for UBE2Q2 Gene

Unigene Clusters for UBE2Q2 Gene

Ubiquitin-conjugating enzyme E2Q family member 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2Q2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for UBE2Q2 Gene

GeneLoc Exon Structure for
UBE2Q2
ECgene alternative splicing isoforms for
UBE2Q2

Expression for UBE2Q2 Gene

mRNA expression in normal human tissues for UBE2Q2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2Q2 Gene

SOURCE GeneReport for Unigene cluster for UBE2Q2 Gene Hs.23033

mRNA Expression by UniProt/SwissProt for UBE2Q2 Gene

Q8WVN8-UB2Q2_HUMAN
Tissue specificity: Detected in hypopharyngeal head and neck squamous cell carcinoma, in tumor masses and invasive epithelium.
genes like me logo Genes that share expressions with UBE2Q2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE2Q2 Gene

Orthologs for UBE2Q2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2Q2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2Q2 35
  • 99.82 (n)
  • 99.73 (a)
UBE2Q2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2Q2 35
  • 93.12 (n)
  • 95.87 (a)
UBE2Q2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2Q2 35
  • 92.42 (n)
  • 91.98 (a)
UBE2Q2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2q2 35
  • 92.96 (n)
  • 94.39 (a)
Ube2q2 16
Ube2q2 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2Q2 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2Q2 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2q2 35
  • 90.43 (n)
  • 92.01 (a)
chicken
(Gallus gallus)
Aves UBE2Q2 35
  • 82.7 (n)
  • 89.81 (a)
UBE2Q2 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68587 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2q2 35
  • 77.57 (n)
  • 87.19 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2q1 35
  • 69.94 (n)
  • 78.04 (a)
ube2q1 36
  • 82 (a)
OneToMany
ube2q2 36
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001452 35
  • 57.29 (n)
  • 54.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2924 35
  • 57.85 (n)
  • 57.02 (a)
CG2924 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-25 35
  • 55.28 (n)
  • 48.06 (a)
ubc-25 36
  • 44 (a)
OneToMany
Species with no ortholog for UBE2Q2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2Q2 Gene

ENSEMBL:
Gene Tree for UBE2Q2 (if available)
TreeFam:
Gene Tree for UBE2Q2 (if available)

Paralogs for UBE2Q2 Gene

Paralogs for UBE2Q2 Gene

Selected SIMAP similar genes for UBE2Q2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with UBE2Q2: view

Variants for UBE2Q2 Gene

Sequence variations from dbSNP and Humsavar for UBE2Q2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs189197 -- 75,894,004(-) CAGAG(A/T)ATGAC intron-variant
rs191394 -- 75,897,759(-) CAGGA(A/G)CTTGA intron-variant
rs335687 -- 75,899,625(-) AATGC(A/G)AAGGC utr-variant-3-prime
rs335688 -- 75,899,511(-) ATGTT(A/G)GAAAG utr-variant-3-prime
rs335689 -- 75,899,461(-) CAACA(C/T)ATTTA missense, reference, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2Q2 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
esv271401 CNV Insertion 20981092
esv2659698 CNV Deletion 23128226

Relevant External Links for UBE2Q2 Gene

HapMap Linkage Disequilibrium report
UBE2Q2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2Q2 Gene

Disorders for UBE2Q2 Gene

Relevant External Links for UBE2Q2

Genetic Association Database (GAD)
UBE2Q2
Human Genome Epidemiology (HuGE) Navigator
UBE2Q2
genes like me logo Genes that share disorders with UBE2Q2: view

No data available for UniProtKB/Swiss-Prot for UBE2Q2 Gene

Publications for UBE2Q2 Gene

  1. Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours. (PMID: 16300736) Seghatoleslam A. … Wasylyk B. (Biochem. Biophys. Res. Commun. 2006) 2 3 4
  2. Overexpression of the novel human gene, UBE2Q2, in breast cancer. (PMID: 20193842) Nikseresht M. … Owji A.A. (Cancer Genet. Cytogenet. 2010) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4
  5. New loci associated with kidney function and chronic kidney disease. (PMID: 20383146) KAPttgen A. … Fox C.S. (Nat. Genet. 2010) 3 48

Products for UBE2Q2 Gene

Sources for UBE2Q2 Gene

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