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Aliases for UBE2Q1 Gene

Aliases for UBE2Q1 Gene

  • Ubiquitin Conjugating Enzyme E2 Q1 2 3 5
  • E2 Ubiquitin-Conjugating Enzyme Q1 3 4
  • Ubiquitin Carrier Protein Q1 3 4
  • Ubiquitin-Protein Ligase Q1 3 4
  • Protein NICE-5 3 4
  • UBE2Q 3 4
  • NICE5 3 4
  • Ubiquitin-Conjugating Enzyme E2Q Family Member 1 2
  • Ubiquitin Conjugating Enzyme E2Q Family Member 1 3
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 1 3
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 2
  • Galactosyl Transferase-Associated Protein 3
  • Ubiquitin-Conjugating Enzyme E2 Q1 3
  • EC 6.3.2.19 61
  • EC 2.3.2.23 4
  • PRO3094 3
  • NICE-5 3
  • GTAP 3

External Ids for UBE2Q1 Gene

Previous HGNC Symbols for UBE2Q1 Gene

  • UBE2Q

Previous GeneCards Identifiers for UBE2Q1 Gene

  • GC01M151336
  • GC01M152787
  • GC01M125884

Summaries for UBE2Q1 Gene

Entrez Gene Summary for UBE2Q1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2Q1 Gene

UBE2Q1 (Ubiquitin Conjugating Enzyme E2 Q1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2Q2.

UniProtKB/Swiss-Prot for UBE2Q1 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2Q1 Gene

Genomics for UBE2Q1 Gene

Regulatory Elements for UBE2Q1 Gene

Enhancers for UBE2Q1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G154333 1.5 Ensembl ENCODE dbSUPER 13.9 +224.3 224338 2.2 PKNOX1 FOXA2 ARID4B SIN3A ZNF48 YY1 ZNF121 ELK1 ZNF143 FOS UBE2Q1 IL6R LOC101928101 ENSG00000201129 UBAP2L MIR190B TPM3 C1orf189 UBE2Q1-AS1 ATP8B2
GH01G154384 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.5 +172.9 172853 2.5 HDGF ATF1 FOXA2 CREB3L1 ARID4B ZNF48 TCF12 ELK1 GATA2 ZNF143 ATP8B2 LOC101928101 RNU7-57P UBE2Q1-AS1 UBE2Q1 SHE TDRD10 C1orf189 SNAPIN UBAP2L
GH01G154606 1.7 FANTOM5 ENCODE dbSUPER 11.1 -49.4 -49437 4.1 HDGF ARNT WRNIP1 ARID4B SIN3A FEZF1 YBX1 ZNF2 YY1 ZNF143 CHRNB2 ENSG00000271267 RUSC1-AS1 CHTOP DPM3 EFNA4 UBE2Q1 DCST1 UBE2Q1-AS1 THBS3
GH01G154483 1.5 Ensembl ENCODE dbSUPER 11.5 +73.5 73521 3.2 GLI4 ZNF2 YY1 GLIS2 GATA2 KLF7 FOS SP3 JUNB TSHZ1 UBE2Q1-AS1 UBE2Q1 CHRNB2 RNU7-57P ATP8B2 ADAR IL6R SHE GBA ENSG00000273110
GH01G154496 1.5 Ensembl ENCODE dbSUPER 11.3 +62.0 62005 1.4 PKNOX1 FOXA2 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 FOS JUNB UBE2Q1-AS1 UBE2Q1 RNU7-57P ATP8B2 ADAR C1orf189 SHE ENSG00000273110
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2Q1 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2Q1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000254577 628 2001 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC

Genomic Location for UBE2Q1 Gene

Chromosome:
1
Start:
154,548,575 bp from pter
End:
154,559,028 bp from pter
Size:
10,454 bases
Orientation:
Minus strand

Genomic View for UBE2Q1 Gene

Genes around UBE2Q1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2Q1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2Q1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Q1 Gene

Proteins for UBE2Q1 Gene

  • Protein details for UBE2Q1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7E8-UB2Q1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q1
    Protein Accession:
    Q7Z7E8
    Secondary Accessions:
    • B4DF92
    • Q29SN7
    • Q3B841
    • Q5I0X2
    • Q6IS04
    • Q6P7P2
    • Q96MV4
    • Q9BVX5
    • Q9UGL6

    Protein attributes for UBE2Q1 Gene

    Size:
    422 amino acids
    Molecular mass:
    46127 Da
    Quaternary structure:
    • Monomer and homodimer. Only the homodimer is linked to ubiquitin through thiolester activation. Interacts (via N-terminus) with B4GALT1 (via N-terminal cytoplasmic domain). The interaction is direct.
    SequenceCaution:
    • Sequence=AAF71141.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH61583.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH87836.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07058.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71173.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB65097.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2Q1 Gene

    Alternative splice isoforms for UBE2Q1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2Q1 Gene

Selected DME Specific Peptides for UBE2Q1 Gene

Q7Z7E8:
  • LNGAVSGSVQA
  • DLQILKEKEG
  • PVLSGGYVLGGGA
  • DRLMKELRDIYRSQS
  • HCNITESYP
  • ATLVKGKARVQFGANK
  • ILLNFSFKDNFPFDPPFVRVV
  • CMELLTKQGWSSAYSIESVIMQI
  • EDLDHYEMKEEEP

Post-translational modifications for UBE2Q1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2Q1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for UBE2Q1 Gene

Gene Families for UBE2Q1 Gene

Protein Domains for UBE2Q1 Gene

Suggested Antigen Peptide Sequences for UBE2Q1 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z7E8

UniProtKB/Swiss-Prot:

UB2Q1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Q1: view

Function for UBE2Q1 Gene

Molecular function for UBE2Q1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). May be involved in hormonal homeostasis in females. Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation.

Enzyme Numbers (IUBMB) for UBE2Q1 Gene

Gene Ontology (GO) - Molecular Function for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275660
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0061631 ubiquitin conjugating enzyme activity IEA --
genes like me logo Genes that share ontologies with UBE2Q1: view
genes like me logo Genes that share phenotypes with UBE2Q1: view

Animal Models for UBE2Q1 Gene

MGI Knock Outs for UBE2Q1:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2Q1

CRISPR Products

miRNA for UBE2Q1 Gene

miRTarBase miRNAs that target UBE2Q1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2Q1 Gene

Localization for UBE2Q1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Q1 Gene

Nucleus. Cell projection, filopodium. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2Q1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
GO:0030175 filopodium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with UBE2Q1: view

Pathways & Interactions for UBE2Q1 Gene

genes like me logo Genes that share pathways with UBE2Q1: view

Pathways by source for UBE2Q1 Gene

UniProtKB/Swiss-Prot Q7Z7E8-UB2Q1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001967 suckling behavior IEA --
GO:0007566 embryo implantation IEA --
GO:0007617 mating behavior IEA --
GO:0009566 fertilization IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with UBE2Q1: view

No data available for SIGNOR curated interactions for UBE2Q1 Gene

Drugs & Compounds for UBE2Q1 Gene

(3) Drugs for UBE2Q1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2Q1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2Q1: view

Transcripts for UBE2Q1 Gene

Unigene Clusters for UBE2Q1 Gene

Ubiquitin-conjugating enzyme E2Q family member 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1:
SP2:
SP3: - -

Relevant External Links for UBE2Q1 Gene

GeneLoc Exon Structure for
UBE2Q1
ECgene alternative splicing isoforms for
UBE2Q1

Expression for UBE2Q1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2Q1 Gene

Protein differential expression in normal tissues from HIPED for UBE2Q1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.6) and Frontal cortex (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2Q1 Gene



Protein tissue co-expression partners for UBE2Q1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2Q1 Gene:

UBE2Q1

SOURCE GeneReport for Unigene cluster for UBE2Q1 Gene:

Hs.607928

mRNA Expression by UniProt/SwissProt for UBE2Q1 Gene:

Q7Z7E8-UB2Q1_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for UBE2Q1 Gene

  • Nervous system(4.6)
  • Skin(4.3)
  • Intestine(2.4)
genes like me logo Genes that share expression patterns with UBE2Q1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2Q1 Gene

Orthologs for UBE2Q1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2Q1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia UBE2Q1 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2Q1 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia UBE2Q1 34 35
  • 97.55 (n)
mouse
(Mus musculus)
Mammalia Ube2q1 34 16 35
  • 94.94 (n)
rat
(Rattus norvegicus)
Mammalia Ube2q1 34
  • 94.55 (n)
dog
(Canis familiaris)
Mammalia UBE2Q1 34 35
  • 93.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 68 (a)
ManyToMany
chicken
(Gallus gallus)
Aves UBE2Q1 35
  • 95 (a)
OneToOne
LOC100858564 34
  • 82.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2924 35
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-25 35
  • 46 (a)
OneToMany
Species where no ortholog for UBE2Q1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBE2Q1 Gene

ENSEMBL:
Gene Tree for UBE2Q1 (if available)
TreeFam:
Gene Tree for UBE2Q1 (if available)

Paralogs for UBE2Q1 Gene

Paralogs for UBE2Q1 Gene

(3) SIMAP similar genes for UBE2Q1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBE2Q1: view

Variants for UBE2Q1 Gene

Sequence variations from dbSNP and Humsavar for UBE2Q1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000179281 -- 154,549,250(+) CTCCC(C/T)ACCTC utr-variant-3-prime
rs1000221447 -- 154,554,348(+) TATAT(A/G)TAACA intron-variant
rs1000334487 -- 154,556,173(+) GAAGA(A/C)CCTTT intron-variant
rs1000388163 -- 154,556,536(+) TTCTC(C/T)CCACC intron-variant
rs1000608682 -- 154,552,843(+) CAGGA(A/G)CATTC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UBE2Q1 Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV gain 19592680

Variation tolerance for UBE2Q1 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2Q1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2Q1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2Q1 Gene

Disorders for UBE2Q1 Gene

Relevant External Links for UBE2Q1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2Q1

No disorders were found for UBE2Q1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2Q1 Gene

Publications for UBE2Q1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I. … Mischke D. (Genome Res. 2001) 3 4 64
  5. Upregulated expression of ubiquitin-conjugating enzyme E2Q1 (UBE2Q1) is associated with enhanced cell proliferation and poor prognosis in human hapatocellular carcinoma. (PMID: 25311764) Chang R. … Qian H. (J. Mol. Histol. 2015) 3 64

Products for UBE2Q1 Gene

Sources for UBE2Q1 Gene

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