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UBE2Q1 Gene

protein-coding   GIFtS: 54
GCID: GC01M154521

Ubiquitin-Conjugating Enzyme E2Q Family Member 1

(Previous name: ubiquitin-conjugating enzyme E2Q (putative))
(Previous symbol: UBE2Q)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2Q Family Member 11 2     GTAP2
UBE2Q1 2 3     NICE-52
Protein NICE-52 3     Galactosyl Transferase-Associated Protein2
Ubiquitin Carrier Protein Q12 3     Ubiquitin-Conjugating Enzyme E2 Q12
Ubiquitin-Protein Ligase Q12 3     Ubiquitin-Conjugating Enzyme E2Q (Putative) 12
EC 6.3.2.193 8     NICE53
Ubiquitin-Conjugating Enzyme E2Q (Putative)1     

External Ids:    HGNC: 156981   Entrez Gene: 555852   Ensembl: ENSG000001607147   UniProtKB: Q7Z7E83   

Export aliases for UBE2Q1 gene to outside databases

Previous GC identifers: GC01M151336 GC01M152787 GC01M125884


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2Q1 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s).
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to
the mouse counterpart. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2Q1 Gene:
UBE2Q1 (ubiquitin-conjugating enzyme E2Q family member 1) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2Q2.

UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8
Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2Q1 gene promoter:
         Egr-3   AhR   AP-1   HOXA3   NRSF form 1   CUTL1   NRSF form 2   Arnt   GATA-2   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2Q1 promoter sequence
   Search Chromatin IP Primers for UBE2Q1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2Q1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q22

UBE2Q1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2Q1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M154521:  view genomic region     (about GC identifiers)

Start:
154,521,051 bp from pter      End:
154,531,504 bp from pter
Size:
10,454 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 Q1  
Size: 422 amino acids; 46127 Da
Sequence caution: Sequence=AAF71141.1; Type=Erroneous initiation; Sequence=AAH61583.1; Type=Erroneous initiation;
Sequence=AAH87836.1; Type=Erroneous initiation; Sequence=AAI07058.1; Type=Erroneous initiation;
Sequence=BAB71173.1; Type=Erroneous initiation; Sequence=CAB65097.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for UBE2Q1:
2QGX (3D)    
Secondary accessions: B4DF92 Q3B841 Q5I0X2 Q6IS04 Q6P7P2 Q96MV4 Q9BVX5 Q9UGL6
Alternative splicing: 2 isoforms:  Q7Z7E8-1   Q7Z7E8-2   

Explore the universe of human proteins at neXtProt for UBE2Q1: NX_Q7Z7E8

Explore proteomics data for UBE2Q1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys46
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2Q1 (Q7Z7E8) (see all 9)
     HCNITESYP  DLQILKEKEG  LNGAVSGSVQA  EDLDHYEMKEEEP 


    See UBE2Q1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060052.3  
    ENSEMBL proteins: 
     ENSP00000292211  
    Reactome Protein details: Q7Z7E8

    UBE2Q1 Human Recombinant Protein Products:

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    Novus Biologicals UBE2Q1 Protein
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for UBE2Q1

     
    Search eBioscience for Proteins for UBE2Q1 

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    LSBio Antibodies in human, mouse, rat for UBE2Q1

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    Cloud-Clone Corp. ELISAs for UBE2Q1
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    Search eBioscience for ELISAs for UBE2Q1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q7Z7E8

    ProtoNet protein and cluster: Q7Z7E8

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2Q1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2Q1_HUMAN, Q7Z7E8
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI16275660
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with UBE2Q1           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ube2q1):
     behavior/neurological  homeostasis/metabolism  mortality/aging  other  reproductive system 

    Find genes that share phenotypes with UBE2Q1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ube2q1tm1Grz for UBE2Q1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2Q1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2Q1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2Q1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2Q1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2Q1:
    hsa-let-7b-5p (MIRT051950), hsa-mir-93-3p (MIRT038864), hsa-mir-1226-3p (MIRT036425), hsa-let-7a-5p (MIRT052525), hsa-mir-186-5p (MIRT044915), hsa-mir-16-5p (MIRT031659), hsa-mir-103a-3p (MIRT027126), hsa-mir-338-3p (MIRT003038)

    Block miRNA regulation of human, mouse, rat UBE2Q1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2Q1 (see all 83):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1321 hsa-miR-15a hsa-miR-485-3p hsa-miR-3142 hsa-miR-3613-3p hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidUBE2Q1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBE2Q1
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2Q1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for UBE2Q1

    Clone
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    OriGene clones in human, mouse for UBE2Q1 (see all 8)
    OriGene ORF clones in mouse, rat for UBE2Q1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2Q1 (NM_017582)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2Q1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2Q1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for UBE2Q1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2Q1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2Q1 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with UBE2Q1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2Q1
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 Reactome Pathway for UBE2Q1
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for UBE2Q1):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2Q1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBE2Q1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for UBE2Q1 (Q7Z7E81, 2, 3 ENSP000002922114) via UniProtKB, MINT, STRING, and/or I2D (see all 592)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STUB1Q9UNE71, 3, ENSP000002195484EBI-1783287,EBI-357085 I2D: score=2 STRING: ENSP00000219548
    IRF2BPLQ9H1B73, ENSP000002386474I2D: score=2 STRING: ENSP00000238647
    RNF26Q9BY783, ENSP000003124394I2D: score=2 STRING: ENSP00000312439
    RNF7Q9UBF63, ENSP000002734804I2D: score=2 STRING: ENSP00000273480
    EXOSC7Q150243, ENSP000002655644I2D: score=1 STRING: ENSP00000265564
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2Q1 (UB2Q1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2Q1 gene: 
    NM_017582.6  

    Unigene Cluster for UBE2Q1:

    Ubiquitin-conjugating enzyme E2Q family member 1
    Hs.607928  [show with all ESTs]
    Unigene Representative Sequence: AY112698
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000292211(uc001fff.1) ENST00000467683 ENST00000491572 ENST00000476612
    ENST00000483639 ENST00000474181 ENST00000497453
    miRNA
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    Block miRNA regulation of human, mouse, rat UBE2Q1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2Q1 (see all 83):
    hsa-miR-323-3p hsa-miR-607 hsa-miR-1321 hsa-miR-15a hsa-miR-485-3p hsa-miR-3142 hsa-miR-3613-3p hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidUBE2Q1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UBE2Q1
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2Q1
    Clone
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    OriGene clones in human, mouse for UBE2Q1 (see all 8)
    OriGene ORF clones in mouse, rat for UBE2Q1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2Q1 (NM_017582)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2Q1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2Q1
    Primer
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    OriGene qPCR primer pairs and template standards for UBE2Q1
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2Q1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2Q1
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2Q1
      QuantiFast Probe-based Assays in human, mouse, rat UBE2Q1

    Additional mRNA sequence: 

    AF116721.1 AJ243666.1 AK056388.1 AK293986.1 AY112698.1 AY948200.1 BC000848.1 BC009286.2 
    BC015316.1 BC061583.1 BC070158.1 BC087836.1 BC107057.2 BC148185.2 CR457219.1 

    12 DOTS entries:

    DT.445463  DT.100787963  DT.95177258  DT.95177259  DT.95177260  DT.97848196  DT.86845719  DT.100731176 
    DT.100787949  DT.121368402  DT.121609964  DT.91741799 

    Selected AceView cDNA sequences (see all 341):

    AI199704 AI686029 AI811270 AI372044 CR597936 BM969062 AA343582 AW243393 
    BE677811 AI621288 N26613 BQ002069 BG680591 AI361075 CB044944 BG029803 
    CA449438 AA311601 BC009286 AA010754 AI968843 CA391436 AI784622 AI292173 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                    -     -         


    ECgene alternative splicing isoforms for UBE2Q1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2Q1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACACTGCTT
    UBE2Q1 Expression
    About this image

    UBE2Q1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2Q1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.607928

    UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2Q1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2Q1
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2Q1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2Q1
    QuantiTect SYBR Green Assays in human, mouse, rat UBE2Q1
    QuantiFast Probe-based Assays in human, mouse, rat UBE2Q1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2Q1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UBE2Q1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2q11 , 5 ubiquitin-conjugating enzyme E2Q (putative) 11, 5 94.94(n)1
    99.29(a)1
      3 (39.19 cM)5
    700931  NM_027315.41  NP_081591.31 
     897736095 
    chicken
    (Gallus gallus)
    Aves LOC1008585641 ubiquitin-conjugating enzyme E2 Q1-like 82.98(n)
    91.24(a)
      100858564  XM_003643367.2  XP_003643415.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29246
    --
    50(a)
    1 → many
    X(2159024-2164789)
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-256
    Protein UBC-25 (ubc-25) mRNA, complete cds
    46(a)
    1 → many
    I(10562970-10564914) WBGene00006720


    ENSEMBL Gene Tree for UBE2Q1 (if available)
    TreeFam Gene Tree for UBE2Q1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2Q1 gene
    UBE2Q22  UBE2QL12  
    3 SIMAP similar genes for UBE2Q1 using alignment to 2 protein entries:     UB2Q1_HUMAN (see all proteins):
    GTAP    UBE2Q2    UBE2QL1

    Find genes that share paralogs with UBE2Q1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2Q1 (see all 245)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs802722151,2
    C,F--154521259(+) GTCCCG/ATCTTT 1 -- ut311Minor allele frequency- A:0.03WA 118
    rs412699151,2
    C,F--154521584(+) GTAGGT/ACCTAA 1 -- ut317Minor allele frequency- A:0.18WA NA CSA EA 366
    rs1836523871,2
    --154521831(+) CCTTGG/TGGGAG 1 -- ut310--------
    rs1463093191,2
    --154521885(+) AGCTAC/GGTCTG 1 -- ut310--------
    rs1883166571,2
    --154522006(+) ACAGCA/GAAGAG 1 -- ut310--------
    rs1416835511,2
    C--154522062(+) GAGAC-/TGTGTCC 1 -- ut310--------
    rs1808887011,2
    C--154522151(+) GAAAAC/TATCTG 1 -- ut310--------
    rs112656341,2
    C,F,A--154522248(+) GGGCAG/AGTGCT 1 -- ut3110Minor allele frequency- A:0.39NA WA EA 372
    rs1873279061,2
    --154522249(+) GGCAAA/GTGCTG 1 -- ut310--------
    rs726981791,2
    C,F--154522394(+) ACCTCC/ACAAGT 1 -- ut311Minor allele frequency- A:0.05NA 120

    HapMap Linkage Disequilibrium report for UBE2Q1 (154521051 - 154531504 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2Q1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv521887CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2Q1
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2Q1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2Q1 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with UBE2Q1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)1, 2 Marenholz I....Mischke D. (Genome Res. 2001)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    7. Expression of the novel human gene, UBE2Q1, in breast tumors. (PubMed id 22167327)1 Seghatoleslam A....Owji A.A. (Mol. Biol. Rep. 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability. (PubMed id 22124266)1 Yoo N.J....Lee S.H. (Pathology 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55585 HGNC: 15698 AceView: UBE2Q Ensembl:ENSG00000160714 euGenes: HUgn55585
    ECgene: UBE2Q1 Kegg: 55585 H-InvDB: UBE2Q1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2Q1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2Q1 gene:
    Search GeneIP for patents involving UBE2Q1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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