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Aliases & Descriptions for UBE2Q1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 6.3.2.19 3 GTAP 2 NICE-5 1 , 2 NICE5 3 OTTHUMP00000035378 2 PRO3094 1 , 2 UBE2Q 2 , 3
Descriptions Protein NICE-5 3 Ubiquitin carrier protein Q1 3 Ubiquitin-protein ligase Q1 3 galactosyl transferase-associated protein 2 ubiquitin-conjugating enzyme E2Q 2 ubiquitin-conjugating enzyme E2Q (putative) 1 ubiquitin-conjugating enzyme E2Q (putative) 1 2 ubiquitin-conjugating enzyme E2Q family member 1 2
Search outside databases for aliases for UBE2Q1 genePrevious GC identifer: GC01M151336
Summaries for UBE2Q1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for UBE2Q1 : The modification of proteins with ubiquitin is an important cellular mechanism for targetingabnormal or short-lived proteins for degradation. Ubiquitination involves at least three classesof enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), andubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzymefamily. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq] UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8 Function : Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
Genomic Location for UBE2Q1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the UBE2Q1 gene Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q22 UBE2Q1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M152787:
(about GC identifiers )
Start:
152,787,675 bp from pter
End:
152,797,744 bp from pter
Size:
10,070 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for UBE2Q1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8 (See
protein sequence )Recommended Name: Ubiquitin-conjugating enzyme E2 Q1 Size : 422 amino acids; 46127 Da
PDB structures from and Proteopedia : 2QGX (3D)
 
Secondary accessions : Q3B841 Q5I0X2 Q6IS04 Q6P7P2 Q96MV4 Q9BVX5 Q9UGL6Alternative splicing : 2 isoforms : Q7Z7E8-1 Q7Z7E8-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_060052.3 ENSEMBL proteins: ENSP00000292211 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for UBE2Q1: Assays for UBE2Q1:
Protein
Domains/ Families for UBE2Q1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q7Z7E8 ProtoNet protein and cluster: Q7Z7E8
1 Blocks protein family : IPB000608 Ubiquitin-conjugating enzymes UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8 Similarity : Belongs to the ubiquitin-conjugating enzyme family
Gene Function for UBE2Q1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017582 Applied Biosystems Silencer ® siRNAs for UBE2Q1 Sigma-Aldrich siRNA and siRNA Panels for UBE2Q1 Sigma-Aldrich shRNA Panels and shRNA for UBE2Q1 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_017582                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017582                                  untagged cDNA clones in CMV expression vector (see all 3 ): BD137288  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_017582 UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8 Function : Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)Catalytic activity : ATP + ubiquitin + protein lysine = AMP + diphosphate + proteinN-ubiquityllysine Enzyme Number (IUBMB): EC 6.3.2.19
5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for UBE2Q1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2Q1 (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8 Pathway : Protein modification; protein ubiquitination
1 Interacting protein for UBE2Q1 (Q7Z7E8 1 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0019941 modification-dependent protein catabolic process
IEA -- GO:0043687 post-translational protein modification
IEA -- GO:0051246 regulation of protein metabolic process
IEA --
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Drugs & Compounds for UBE2Q1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for UBE2Q1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_017582 Sigma-Aldrich siRNA and siRNA Panels for UBE2Q1 Sigma-Aldrich shRNA Panels and shRNA for UBE2Q1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_017582
REFSEQ mRNAs for UBE2Q1 gene: NM_017582.6
Applied Biosystems TaqMan ® Gene Expression Assays: NM_017582
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_017582                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_017582                                  untagged cDNA clones in CMV expression vector (see all 3 ): BD137288  
Additional cDNA sequence: AF116721.1 AJ243666.1 AK056388.1 AK293986.1 AY112698.1 AY948200.1 BC000848.1 BC009286.2 BC015316.1 BC061583.1 BC070158.1 BC087836.1 BC107057.2 BC148185.2 CR457219.1 CR597936.1 CR608922.1 CR613113.1 CR620497.1 CR624734.1
12 DOTS entries : DT.445463 DT.100787963 DT.95177258 DT.95177259 DT.97848196 DT.86845719 DT.100731176 DT.100787949 DT.121609964 DT.91741799 DT.95177260 DT.121368402
24/341 AceView cDNA sequences (see all 341
):BM973438 BC015316 BE042835 CB044944 BM969062 AI926564 AI361075 BM452095 N39701 BQ228412 BX393477 AI347988 BE906222 AI686029 AA815047 BU729958 AA478121 CB120432 BQ278712 CR608922 AI968843 AW189046 BM698867 AL534466
highest scoring ESTs for UBE2Q1 :AL535478 AL541381 AL548646 AY112698 BE268986 BE561456 BE883304 BG765585 BM716412 BQ212893
Unigene Cluster for UBE2Q1: Ubiquitin-conjugating enzyme E2Q family member 1 Hs.607928 [show with all ESTs ] Unigene Representative Sequence: AY112698 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q1 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 SP1 :                             SP2 :                             SP3 :                       -   -    
About this scheme ECgene alternative splicing isoforms for UBE2Q1 1 Ensembl transcript including schematic representation : ENST00000292211
Expression for UBE2Q1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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UBE2Q1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for UBE2Q1 1 / 2 / 3
10 probe-sets matching UBE2Q1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TACACTGCTTSOURCE GeneReport for Unigene cluster: Hs.607928 UniProtKB/Swiss-Prot: UB2Q1_HUMAN, Q7Z7E8 Tissue specificity : Widely expressed
Orthologs for UBE2Q1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for UBE2Q1 gene from 4 species
About this table Species with no ortholog for UBE2Q1 ENSEMBL Gene Tree for UBE2Q1 Paralogs for UBE2Q1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for UBE2Q1 gene UBE2Q2 2 ENSG00000189136 2 ENSG00000215218 2
SNPs/Variants for UBE2Q1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for UBE2Q1 (up to first 250kb)
Disorders & Mutations for UBE2Q1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for UBE2Q1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for UBE2Q1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for UBE2Q1 gene : The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159) 3, 4 Marenholz I....Mischke D. (2001) Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. (PubMed id 16275660) 3 Grelle G....Wanker E.E. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107410) 3 Wistow G.... Peterson K. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 4 Aoki H.... Hino O. (2000) PISSLRE, a human novel CDC2-related protein kinase. (PubMed id 8208557) 1 Grana X.... Giordano A. (1994)
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Genome Databases showing UBE2Q1
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euGenes ,
Ensembl ,
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ECgene ,
and/or
H-InvDB )
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Other Databases showing UBE2Q1
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Specialized Databases showing UBE2Q1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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