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Aliases for UBE2Q1 Gene

Aliases for UBE2Q1 Gene

  • Ubiquitin-Conjugating Enzyme E2Q Family Member 1 2 3
  • Ubiquitin Carrier Protein Q1 3 4
  • Ubiquitin-Protein Ligase Q1 3 4
  • Protein NICE-5 3 4
  • EC 6.3.2.19 4 63
  • UBE2Q 3 4
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 1 3
  • Ubiquitin-Conjugating Enzyme E2Q (Putative) 2
  • Galactosyl Transferase-Associated Protein 3
  • Ubiquitin-Conjugating Enzyme E2 Q1 3
  • PRO3094 3
  • NICE-5 3
  • NICE5 4
  • GTAP 3

External Ids for UBE2Q1 Gene

Previous HGNC Symbols for UBE2Q1 Gene

  • UBE2Q

Previous GeneCards Identifiers for UBE2Q1 Gene

  • GC01M151336
  • GC01M152787
  • GC01M125884

Summaries for UBE2Q1 Gene

Entrez Gene Summary for UBE2Q1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is 98% identical to the mouse counterpart. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2Q1 Gene

UBE2Q1 (Ubiquitin-Conjugating Enzyme E2Q Family Member 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2Q2.

UniProtKB/Swiss-Prot for UBE2Q1 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). May be involved in hormonal homeostasis in females (By similarity). Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2Q1 Gene

Genomics for UBE2Q1 Gene

Regulatory Elements for UBE2Q1 Gene

Genomic Location for UBE2Q1 Gene

Start:
154,548,575 bp from pter
End:
154,559,028 bp from pter
Size:
10,454 bases
Orientation:
Minus strand

Genomic View for UBE2Q1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2Q1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2Q1 Gene

Proteins for UBE2Q1 Gene

  • Protein details for UBE2Q1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7E8-UB2Q1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q1
    Protein Accession:
    Q7Z7E8
    Secondary Accessions:
    • B4DF92
    • Q29SN7
    • Q3B841
    • Q5I0X2
    • Q6IS04
    • Q6P7P2
    • Q96MV4
    • Q9BVX5
    • Q9UGL6

    Protein attributes for UBE2Q1 Gene

    Size:
    422 amino acids
    Molecular mass:
    46127 Da
    Quaternary structure:
    • Monomer and homodimer. Only the homodimer is linked to ubiquitin through thiolester activation. Interacts (via N-terminus) with B4GALT1 (via N-terminal cytoplasmic domain). The interaction is direct.
    SequenceCaution:
    • Sequence=AAF71141.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH61583.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH87836.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI07058.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71173.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB65097.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2Q1 Gene

    Alternative splice isoforms for UBE2Q1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2Q1 Gene

Proteomics data for UBE2Q1 Gene at MOPED

Post-translational modifications for UBE2Q1 Gene

  • Ubiquitination at Lys46
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2Q1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for UBE2Q1 Gene

Gene Families for UBE2Q1 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2Q1 Gene

Suggested Antigen Peptide Sequences for UBE2Q1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7E8

UniProtKB/Swiss-Prot:

UB2Q1_HUMAN :
  • Q7Z7E8
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2Q1: view

Function for UBE2Q1 Gene

Molecular function for UBE2Q1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Catalyzes the covalent attachment of ubiquitin to other proteins (Potential). May be involved in hormonal homeostasis in females (By similarity). Involved in regulation of B4GALT1 cell surface expression, B4GALT1-mediated cell adhesion to laminin and embryoid body formation (By similarity).

Enzyme Numbers (IUBMB) for UBE2Q1 Gene

Gene Ontology (GO) - Molecular Function for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16275660
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2Q1: view
genes like me logo Genes that share phenotypes with UBE2Q1: view

Animal Models for UBE2Q1 Gene

MGI Knock Outs for UBE2Q1:

No data available for Transcription Factor Targeting and HOMER Transcription for UBE2Q1 Gene

Localization for UBE2Q1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2Q1 Gene

Nucleus. Cell projection, filopodium. Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2Q1 Gene COMPARTMENTS Subcellular localization image for UBE2Q1 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IEA --
GO:0030175 filopodium IEA --
genes like me logo Genes that share ontologies with UBE2Q1: view

Pathways for UBE2Q1 Gene

genes like me logo Genes that share pathways with UBE2Q1: view

UniProtKB/Swiss-Prot Q7Z7E8-UB2Q1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2Q1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001967 suckling behavior IEA --
GO:0007566 embryo implantation IEA --
GO:0007617 mating behavior IEA --
GO:0009566 fertilization IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with UBE2Q1: view

Transcripts for UBE2Q1 Gene

Unigene Clusters for UBE2Q1 Gene

Ubiquitin-conjugating enzyme E2Q family member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2Q1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1:
SP2:
SP3: - -

Relevant External Links for UBE2Q1 Gene

GeneLoc Exon Structure for
UBE2Q1
ECgene alternative splicing isoforms for
UBE2Q1

Expression for UBE2Q1 Gene

mRNA expression in normal human tissues for UBE2Q1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2Q1 Gene

SOURCE GeneReport for Unigene cluster for UBE2Q1 Gene Hs.607928

mRNA Expression by UniProt/SwissProt for UBE2Q1 Gene

Q7Z7E8-UB2Q1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with UBE2Q1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBE2Q1 Gene

Orthologs for UBE2Q1 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2Q1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2Q1 35
  • 99.84 (n)
  • 100 (a)
UBE2Q1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2Q1 35
  • 97.55 (n)
  • 100 (a)
UBE2Q1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2Q1 35
  • 93.06 (n)
  • 99.73 (a)
UBE2Q1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2q1 35
  • 94.94 (n)
  • 99.29 (a)
Ube2q1 16
Ube2q1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2Q1 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ube2q1 35
  • 94.55 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves LOC100858564 35
  • 82.98 (n)
  • 91.24 (a)
UBE2Q1 36
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2924 36
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-25 36
  • 46 (a)
OneToMany
Species with no ortholog for UBE2Q1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBE2Q1 Gene

ENSEMBL:
Gene Tree for UBE2Q1 (if available)
TreeFam:
Gene Tree for UBE2Q1 (if available)

Paralogs for UBE2Q1 Gene

Paralogs for UBE2Q1 Gene

Selected SIMAP similar genes for UBE2Q1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBE2Q1: view

Variants for UBE2Q1 Gene

Sequence variations from dbSNP and Humsavar for UBE2Q1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14689 -- 154,550,111(+) CATAG(A/G)TAAGG utr-variant-3-prime, downstream-variant-500B
rs1140876 -- 154,551,438(-) CCACA(C/T)TGGTG reference, synonymous-codon
rs4074436 -- 154,559,434(-) TTCCT(C/T)ATTTT upstream-variant-2KB
rs4076089 -- 154,559,558(-) GACTC(C/T)GTGGA upstream-variant-2KB
rs4078519 -- 154,555,610(+) TAGTT(C/T)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2Q1 Gene

Variant ID Type Subtype PubMed ID
nsv521887 CNV Gain 19592680

Relevant External Links for UBE2Q1 Gene

HapMap Linkage Disequilibrium report
UBE2Q1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2Q1 Gene

Disorders for UBE2Q1 Gene

No disorders were found for UBE2Q1 Gene.

No data available for UniProtKB/Swiss-Prot for UBE2Q1 Gene

Publications for UBE2Q1 Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  2. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I. … Mischke D. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. (PMID: 16275660) Grelle G. … Wanker E.E. (Mol. Cell. Proteomics 2006) 3

Products for UBE2Q1 Gene

Sources for UBE2Q1 Gene

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