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UBE2O Gene

protein-coding   GIFtS: 59
GCID: GC17M074385

Ubiquitin-Conjugating Enzyme E2O

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2O1 2     E2-230K2
Ubiquitin Carrier Protein O2 3     Ubiquitin-Conjugating Enzyme E2 O2
Ubiquitin-Conjugating Enzyme E2 Of 230 KDa2 3     EC 6.3.2.193
Ubiquitin-Conjugating Enzyme E2-230K2 3     KIAA17343
Ubiquitin-Protein Ligase O2 3     

External Ids:    HGNC: 295541   Entrez Gene: 638932   Ensembl: ENSG000001759317   UniProtKB: Q9C0C93   

Export aliases for UBE2O gene to outside databases

Previous GC identifers: GC17M071898 GC17M069814


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UBE2O Gene:
UBE2O (ubiquitin-conjugating enzyme E2O) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2Z.

UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9
Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)

Gene Wiki entry for UBE2O Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2O gene promoter:
         TBP   Pax-5   MIF-1   CREB   MZF-1   AREB6   Nkx6-1   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2O promoter sequence
   Search Chromatin IP Primers for UBE2O

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2O


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

UBE2O Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2O gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074385:  view genomic region     (about GC identifiers)

Start:
74,385,532 bp from pter      End:
74,449,288 bp from pter
Size:
63,757 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 O  
Size: 1292 amino acids; 141293 Da
Sequence caution: Sequence=AAH22237.1; Type=Erroneous initiation; Sequence=AAH25977.1; Type=Erroneous initiation;
Sequence=AAH36820.1; Type=Erroneous initiation; Sequence=AAH51868.2; Type=Erroneous initiation;
Sequence=BAB14320.1; Type=Erroneous initiation; Sequence=BAB14948.1; Type=Erroneous initiation;
Sequence=BAB15313.1; Type=Erroneous initiation; Sequence=BAB21825.1; Type=Erroneous initiation;
Secondary accessions: A6NDU5 Q69YP4 Q6PIZ2 Q86UA4 Q8N425 Q8TBN1 Q9BSW1 Q9H6E6 Q9H7E4 Q9H9B2

Explore the universe of human proteins at neXtProt for UBE2O: NX_Q9C0C9

Explore proteomics data for UBE2O at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys132, Lys212, Lys283, Lys373, Lys521, Lys620, Lys815, Lys819, Lys825, Lys866,
                                 Lys990
  • Modification sites at PhosphoSitePlus

  • See UBE2O Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_071349.3  
    ENSEMBL proteins: 
     ENSP00000323687   ENSP00000468498   ENSP00000467623  
    Reactome Protein details: Q9C0C9

    UBE2O Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for UBE2O
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    Novus Biologicals UBE2O Proteins
    Novus Biologicals UBE2O Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBE2O

     
    Search eBioscience for Proteins for UBE2O 

     
    antibodies-online proteins for UBE2O (4 products) 

     
    antibodies-online peptides for UBE2O

    UBE2O Antibody Products:

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    antibodies-online antibodies for UBE2O (29 products) 

    UBE2O Assay Products:

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    Cloud-Clone Corp. ELISAs for UBE2O
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    antibodies-online kits for UBE2O (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q9C0C9

    ProtoNet protein and cluster: Q9C0C9

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2O           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2O_HUMAN, Q9C0C9
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with UBE2O           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2O:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Ube2o (no phenotypes)

    Find genes that share phenotypes with UBE2O           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ube2otm1(KOMP)Mbp for UBE2O

       genOway: Develop your customized and physiologically relevant rodent model for UBE2O

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2O:
    hsa-mir-744-5p (MIRT037423), hsa-mir-328-3p (MIRT043811), hsa-mir-93-5p (MIRT048803), hsa-mir-30c-1-3p (MIRT038542), hsa-mir-505-3p (MIRT041058), hsa-mir-335-5p (MIRT017347), hsa-mir-877-3p (MIRT037063)

    Block miRNA regulation of human, mouse, rat UBE2O using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2O (see all 37):
    hsa-miR-4291 hsa-miR-4254 hsa-miR-330-5p hsa-miR-30d hsa-miR-30a hsa-miR-124 hsa-miR-4325 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidUBE2O 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBE2O
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2O

    Gene Editing
    Products:
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    Clone
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    OriGene clones in human, mouse for UBE2O (see all 8)
    OriGene ORF clones in mouse, rat for UBE2O
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2O (NM_022066)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2O
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2O

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2O


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2O About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with UBE2O           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for UBE2O
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for UBE2O):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBE2O
    Interactions:

        Search GeneGlobe Interaction Network for UBE2O

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2O (Q9C0C91, 3 ENSP000003236874) via UniProtKB, MINT, STRING, and/or I2D (see all 46)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237071P143733, ENSP000004052294I2D: score=2 STRING: ENSP00000405229
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    ENSG00000234495P143733I2D: score=2 
    TRIM27P143733I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2O

    4 HMDB Compounds for UBE2O    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2O gene: 
    NM_022066.3  

    Unigene Cluster for UBE2O:

    Ubiquitin-conjugating enzyme E2O
    Hs.16130  [show with all ESTs]
    Unigene Representative Sequence: NM_022066
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319380(uc002jrl.4 uc002jrm.4 uc002jrn.4) ENST00000587127
    ENST00000586409 ENST00000587581 ENST00000590658 ENST00000586505
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBE2O using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2O (see all 37):
    hsa-miR-4291 hsa-miR-4254 hsa-miR-330-5p hsa-miR-30d hsa-miR-30a hsa-miR-124 hsa-miR-4325 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidUBE2O 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBE2O
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2O
    Clone
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    OriGene clones in human, mouse for UBE2O (see all 8)
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    GenScript: all cDNA clones in your preferred vector: UBE2O (NM_022066)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2O
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2O
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2O
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2O
      QuantiFast Probe-based Assays in human, mouse, rat UBE2O

    Additional mRNA sequence: 

    AB051521.1 AK000926.1 AK022940.1 AK024657.1 AK025999.1 AK225412.1 AL832432.1 BC004525.2 
    BC022237.1 BC025977.1 BC036820.1 BC051868.2 

    7 DOTS entries:

    DT.415431  DT.100780454  DT.95295490  DT.120980180  DT.92454174  DT.99932745  DT.101975536 

    Selected AceView cDNA sequences (see all 233):

    AI698407 BU948231 BE670567 AI080509 BP371308 NM_022066 BU740780 BQ962753 
    BQ645258 CD672581 AI083584 AI926347 AL832432 AI698890 AI831836 AI699570 
    AK025999 BF593833 BQ187301 BQ071266 BQ070316 BQ056786 AB051521 BQ437129 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2O    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
    SP1:                                      -                                                                       -                     
    SP2:                                      -                                                                                             
    SP3:                                                                                                              -                     
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for UBE2O

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2O expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGATGTG
    UBE2O Expression
    About this image


    UBE2O expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
             Retina
    UBE2O Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2O Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16130

    UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9
    Tissue specificity: Predominantly expressed in skeletal muscle and heart

        Custom PCR Arrays for UBE2O
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    QuantiFast Probe-based Assays in human, mouse, rat UBE2O
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2O

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2O gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2o1 , 5 ubiquitin-conjugating enzyme E2O1, 5 88.55(n)1
    94.57(a)1
      11 (81.42 cM)5
    2173421  NM_173755.31  NP_776116.21 
     1165377405 
    chicken
    (Gallus gallus)
    Aves UBE2O1 ubiquitin-conjugating enzyme E2O 77.46(n)
    83.45(a)
      417359  XM_415619.4  XP_415619.4 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2O6
    ubiquitin-conjugating enzyme E2O
    74(a)
    1 ↔ 1
    2(112189610-112286050)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ094425.12   -- 78.65(n)    BJ094425.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK397980.12   -- 70.28(n)    CK397980.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102546
    --
    25(a)
    1 ↔ 1
    3R(19514729-19520705)
    barley
    (Hordeum vulgare)
    Liliopsida Hv.23002 Transcribed sequence with weak similarity to protein more 73.47(n)    CA009121.1 


    ENSEMBL Gene Tree for UBE2O (if available)
    TreeFam Gene Tree for UBE2O (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2O gene
    UBE2Z2  BIRC62  
    5 SIMAP similar genes for UBE2O using alignment to 3 protein entries:     UBE2O_HUMAN (see all proteins):
    UBE2Z    UBE2D2    UBE2D3    UBE2A    UBE2N

    Find genes that share paralogs with UBE2O           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2O (see all 1357)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504426001,2
    --74385170(+) GAGTTA/GTGGCA 1 -- int10--------
    rs1451510941,2
    C--74385308(+) ACCACC/TGGCCA 1 -- int10--------
    rs1486705411,2
    C--74385399(+) CGGGT-/GGGGGT 1 -- int10--------
    rs2015436041,2
    C--74385588(+) GAGCC-/ACCACAA 1 -- int10--------
    rs8980841,2
    C,F,H--74385591(-) TTTTTT/GTGTTG 1 -- int111Minor allele frequency- G:0.10NS WA NA CSA 900
    rs1998453091,2
    C--74385591(+) CAACA-/C/CA  
            
    AAAAA
    1 -- int10--------
    rs1433771351,2
    C--74385669(+) CAGTAA/GGCATT 1 -- ut310--------
    rs1390269391,2
    C--74385705(+) GGGAAC/GCACAG 1 -- ut310--------
    rs785607431,2
    F--74385782(+) GGTCCG/AGCTCC 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1854394391,2
    --74385795(+) CCTCCA/CGCAGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2O (74385532 - 74449288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBE2O:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833547CNV Loss17160897
    nsv2145CNV Loss18451855
    nsv833549CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2O
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with UBE2O           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: UBE2O (1 document)

    Export disorders for UBE2O gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2O gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with UBE2O)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PubMed id 11311559)1, 2, 3 Yokota T.... Emi M. (Gene 2001)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E2-230K-mediated monoubiquitination of SMAD6. (PubMed id 23455153)1 Zhang X....Ten Dijke P. (EMBO J. 2013)
    6. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response. (PubMed id 23751493)1 Poulsen S.L....Mailand N. (J. Cell Biol. 2013)
    7. UBE2O negatively regulates TRAF6-mediated NF-I_B activation by inhibiting TRAF6 polyubiquitination. (PubMed id 23381138)1 Zhang X....ten Dijke P. (Cell Res. 2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (Biochem. J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 63893 HGNC: 29554 AceView: E2-230K Ensembl:ENSG00000175931 euGenes: HUgn63893
    ECgene: UBE2O Kegg: 63893 H-InvDB: UBE2O

    (According to HUGE)
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    HUGE: KIAA1734

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2O Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2O gene:
    Search GeneIP for patents involving UBE2O

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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