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Aliases & Descriptions for UBE2O
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| E2-230K 1, 2, 3 | | EC 6.3.2.19 3 | | FLJ12878 2 | | KIAA1734 2, 3 |
| | | Descriptions |
|---|
| Ubiquitin carrier protein O 3 | | Ubiquitin-conjugating enzyme E2 of 230 kDa 3 | | Ubiquitin-protein ligase O 3 | | ubiquitin-conjugating enzyme E2O 2 |
|
| | Search outside databases for aliases for UBE2O gene |
Summaries for UBE2O(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)Gene Wiki entry for UBE2O |
Genomic Location for UBE2O
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBE2O gene 
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1UBE2O Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M071898:
(about GC identifiers)
Start:
|
71,897,491 bp from pter |
End:
|
71,960,883 bp from pter |
Size:
|
63,393 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010641.15
| Proteins for UBE2O
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 O Size: 1292 amino acids; 141293 Da
Secondary accessions: A6NDU5 Q69YP4 Q6PIZ2 Q86UA4 Q8N425 Q8TBN1 Q9BSW1 Q9H6E6 Q9H7E4 Q9H9B2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_071349.3
ENSEMBL proteins: ENSP00000323687
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for UBE2O: Assays for UBE2O: | Protein
Domains/ Families for UBE2O(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9C0C9
ProtoNet protein and cluster: Q9C0C9 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Similarity: Belongs to the ubiquitin-conjugating enzyme family | Gene Function for UBE2O
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022066
Applied Biosystems Silencer® siRNAs for UBE2O
Sigma-Aldrich siRNA and siRNA Panels for UBE2O  Sigma-Aldrich shRNA Panels and shRNA for UBE2O  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_022066                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_022066                                  untagged cDNA clones in CMV expression vector (see all 2): NM_022066 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_022066
UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- | | GO:0016874 | ligase activity |
IEA | -- | About this table | Pathways & Interactions for UBE2O
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Pathway: Protein modification; protein ubiquitination 1 Interacting protein for UBE2O (ENSP000003236873) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for UBE2O(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBE2O
|
Transcripts for UBE2O(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_022066
Sigma-Aldrich siRNA and siRNA Panels for UBE2O  Sigma-Aldrich shRNA Panels and shRNA for UBE2O  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_022066 REFSEQ mRNAs for UBE2O gene: NM_022066.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_022066               OriGene GFP tagged cDNA clone in CMV expression vector: NM_022066                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_022066                                  untagged cDNA clones in CMV expression vector (see all 2): NM_022066  Additional cDNA sequence: AB051521.1 AK000926.1 AK022940.1 AK024657.1 AK025999.1 AK225412.1 AL832432.1 BC004525.2 BC022237.1 BC025977.1 BC036820.1 BC051868.2 7 DOTS entries: DT.415431 DT.100780454 DT.95295490 DT.92454174 DT.99932745 DT.101975536 DT.120980180 24/233 AceView cDNA sequences (see all 233
):AK022940 BQ070316 BU740780 BM727219 AW152157 CD672580 AI160123 BQ645258 BP371308 BU189342 BC004525 AI433415 BU948231 BF593833 AI538409 BQ217875 BE645208 AI698890 AI831836 BQ071266 BQ437129 AK025999 NM_022066 BU859314
highest scoring ESTs for UBE2O:AA195077 AA341325 AB051521 BC007822 BF726224 CB960973 CD580295 CK000406 AA135179 AA135353 Unigene Cluster for UBE2O: Ubiquitin-conjugating enzyme E2O Hs.16130 [show with all ESTs]Unigene Representative Sequence: NM_022066
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2O
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBE2O
1 Ensembl transcript including schematic representation: ENST00000319380
|
Expression for UBE2O
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBE2O expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBE2O
1 / 2 / 3 4 probe-sets matching UBE2O gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGAGATGTG
SOURCE GeneReport for Unigene cluster: Hs.16130 UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Tissue specificity: Predominantly expressed in skeletal muscle and heart |
Orthologs for UBE2O
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2O gene from 5/13 species (see all 13
)
About this table Species with no ortholog for UBE2O
ENSEMBL Gene Tree for UBE2O | Paralogs for UBE2O(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBE2O gene
- UBE2Z2 BIRC62
|
SNPs/Variants for UBE2O(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBE2O (up to first 250kb)
|
Disorders & Mutations for UBE2O
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for UBE2O(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBE2O (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/16 PubMed articles for UBE2O gene (see all 16
):- Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PubMed id 11311559)2, 3, 4 Yokota T.... Emi M. (2001)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)2, 3, 4 Nagase T....Ohara O. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. (PubMed id 17287340)4 Molina H.... Pandey A. (2007)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)4 Zody M.C.... Nusbaum C. (2006)
|
Search for UBE2O
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBE2O
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBE2O
(According to HUGE)
About This Section
| |
Specialized Databases showing UBE2O(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBE2O(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBE2O:

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Incremental update: 13 Oct 2009
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