UBE2O Gene
protein-coding GIFtS: 55
GCID: GC17M074385
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|
ubiquitin-conjugating enzyme E2O
| |
Aliases for UBE2O gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2O1 2 | | Ubiquitin-Protein Ligase O2 3 | | E2-230K1 2 | | Ubiquitin-Conjugating Enzyme E2 O2 | | Ubiquitin Carrier Protein O2 3 | | EC 6.3.2.193 | | Ubiquitin-Conjugating Enzyme E2 Of 230 KDa2 3 | | KIAA17343 | | Ubiquitin-Conjugating Enzyme E2-230K2 3 | | |
Export aliases for UBE2O gene to outside databasesPrevious GC identifers: GC17M071898 GC17M069814 |
Summaries for UBE2O gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity) Gene Wiki entry for UBE2O
|
Genomic Views for UBE2O gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UBE2O gene promoter: TBP Pax-5 MIF-1 CREB MZF-1 AREB6 Nkx6-1 deltaCREB Pax-4a Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2O
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2O |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1UBE2O Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M074385: view genomic region
(about GC identifiers)
Start:
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74,385,532 bp from pter |
End:
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74,449,288 bp from pter |
Size:
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63,757 bases |
Orientation:
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minus strand |
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Proteins for UBE2O gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 O Size: 1292 amino acids; 141293 Da
Sequence caution: Sequence=AAH22237.1; Type=Erroneous initiation; Sequence=AAH25977.1; Type=Erroneous initiation;Sequence=AAH36820.1; Type=Erroneous initiation; Sequence=AAH51868.2; Type=Erroneous initiation; Sequence=BAB14320.1;Type=Erroneous initiation; Sequence=BAB14948.1; Type=Erroneous initiation; Sequence=BAB15313.1; Type=Erroneousinitiation; Sequence=BAB21825.1; Type=Erroneous initiation;
Secondary accessions: A6NDU5 Q69YP4 Q6PIZ2 Q86UA4 Q8N425 Q8TBN1 Q9BSW1 Q9H6E6 Q9H7E4 Q9H9B2Explore the universe of human proteins at neXtProt for UBE2O: NX_Q9C0C9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C0C9 UBE2O Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071349.3 ENSEMBL proteins: ENSP00000323687 ENSP00000468498 ENSP00000467623 Reactome Protein details: Q9C0C9 Human Recombinant Protein Products:
UBE2O Antibody Products: Assay Products for UBE2O: |
Protein
Domains / Families for UBE2O gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2O for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9C0C9ProtoNet protein and cluster: Q9C0C9 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function for UBE2O gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.191
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2O (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2O (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBE2O (NM_022066) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2O | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2O  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2O |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
UBE2O for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UBE2O:
|
Pathways & Interactions for UBE2O gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources See GeneCards unified pathways Show all pathways
5
Reactome Pathways for UBE2O
1
Kegg Pathway (Kegg details for UBE2O): UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Pathway: Protein modification; protein ubiquitination
UBE2O for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2O
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/35 Interacting proteins for UBE2O (Q9C0C93 ENSP000003236874) via UniProtKB, MINT, STRING, and/or I2D (see all 35) About this table
|
Drugs & Compounds for UBE2O gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for UBE2O
4 HMDB Compounds for UBE2O About this table Search CenterWatch for drugs/clinical trials and news about UBE2O 
|
Transcripts for UBE2O gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for UBE2O gene: NM_022066.3 Unigene Cluster for UBE2O: Ubiquitin-conjugating enzyme E2O Hs.16130 [show with all ESTs]Unigene Representative Sequence: NM_0220666 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000319380(uc002jrl.4 uc002jrm.4 uc002jrn.4) ENST00000587127 ENST00000586409 ENST00000587581 ENST00000590658 ENST00000586505
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2O (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2O (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBE2O (NM_022066) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2O | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2O  |
Additional cDNA sequence: AB051521.1 AK000926.1 AK022940.1 AK024657.1 AK025999.1 AK225412.1 AL832432.1 BC004525.2 BC022237.1 BC025977.1 BC036820.1 BC051868.2 7 DOTS entries: DT.415431 DT.100780454 DT.95295490 DT.120980180 DT.92454174 DT.99932745 DT.101975536 24/233 AceView cDNA sequences (see all 233): BF593833 AI538409 BF110828 BC051868 BU859314 BM723178 BU189342 AK025999 CF140041 AA309174 BF726224 CD672581 AI926347 AI699570 AI080509 BC004525 AI160123 BP371308 BQ070316 BC036820 AI433415 AW152157 AB051521 BU740780 GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2O About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 | ^ | 18 | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for UBE2O
|
Expression for UBE2O gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2O expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TGGAGATGTG
About this image See UBE2O Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UBE2O
SOURCE GeneReport for Unigene cluster: Hs.16130 UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9Tissue specificity: Predominantly expressed in skeletal muscle and heart SABiosciences Custom PCR Arrays for UBE2O
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2O Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2O | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2O | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2O | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2O |
Orthologs for UBE2O gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2O gene from 8/24 species (see all 24) About this table
ENSEMBL Gene Tree for UBE2O (if available) TreeFam Gene Tree for UBE2O (if available)  |
Paralogs for UBE2O gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for UBE2O gene
- UBE2B2 UBE2S2 BIRC62 UBE2Z2 UBE2A2
5 SIMAP similar genes for UBE2O using alignment to 3 protein entries: UBE2O_HUMAN (see all proteins):UBE2Z UBE2D2 UBE2D3 UBE2N UBE2A
UBE2O for paralogs About GeneDecksing
|
Genomic Variants for UBE2O gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 17 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for UBE2O (74385532 - 74449288 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for UBE2O 1 CNV: 5032  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2O |
|
Disorders
/ Diseases for UBE2O gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2O for disorders About GeneDecksing
3 diseases for UBE2O: About MalaCardshepatitis b hepatitis prostatitis Human Genome Epidemiology (HuGE) Navigator: UBE2O (1 document) Export disorders for UBE2O gene to outside databases
|
Publications for UBE2O gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBE2O gene, integrated from 9 sources (see all 36): (articles sorted by number of sources associating them with UBE2O) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PubMed id 11311559)1, 2, 3 Yokota T.... Emi M. (2001)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
|
External Searches for UBE2O gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBE2O gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2O gene
(According to HUGE)
About This Section
| |
Specialized Databases showing UBE2O gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for UBE2O | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBE2O gene: Search GeneIP for patents involving UBE2O
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for UBE2O gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | UBE2O Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2O |
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| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2O |
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