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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2O Gene

protein-coding   GIFtS: 57
GCID: GC17M074385

Ubiquitin-Conjugating Enzyme E2O

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2O1 2     E2-230K2
Ubiquitin Carrier Protein O2 3     Ubiquitin-Conjugating Enzyme E2 O2
Ubiquitin-Conjugating Enzyme E2 Of 230 KDa2 3     EC 6.3.2.193
Ubiquitin-Conjugating Enzyme E2-230K2 3     KIAA17343
Ubiquitin-Protein Ligase O2 3     

External Ids:    HGNC: 295541   Entrez Gene: 638932   Ensembl: ENSG000001759317   UniProtKB: Q9C0C93   

Export aliases for UBE2O gene to outside databases

Previous GC identifers: GC17M071898 GC17M069814


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBE2O Gene: 
UBE2O (ubiquitin-conjugating enzyme E2O) is a protein-coding gene. Diseases associated with UBE2O include hepatitis b, and hepatitis, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is BIRC6.

UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9
Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)

Gene Wiki entry for UBE2O Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2O gene promoter:
         TBP   Pax-5   MIF-1   CREB   MZF-1   AREB6   Nkx6-1   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2O promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2O

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2O


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25.1

UBE2O Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2O gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M074385:  view genomic region     (about GC identifiers)

Start:
74,385,532 bp from pter      End:
74,449,288 bp from pter
Size:
63,757 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 O  
Size: 1292 amino acids; 141293 Da
Sequence caution: Sequence=AAH22237.1; Type=Erroneous initiation; Sequence=AAH25977.1; Type=Erroneous initiation;
Sequence=AAH36820.1; Type=Erroneous initiation; Sequence=AAH51868.2; Type=Erroneous initiation;
Sequence=BAB14320.1; Type=Erroneous initiation; Sequence=BAB14948.1; Type=Erroneous initiation;
Sequence=BAB15313.1; Type=Erroneous initiation; Sequence=BAB21825.1; Type=Erroneous initiation;
Secondary accessions: A6NDU5 Q69YP4 Q6PIZ2 Q86UA4 Q8N425 Q8TBN1 Q9BSW1 Q9H6E6 Q9H7E4 Q9H9B2

Explore the universe of human proteins at neXtProt for UBE2O: NX_Q9C0C9

Explore proteomics data for UBE2O at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9C0C9

  • UBE2O Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2O Protein Expression
    REFSEQ proteins: NP_071349.3  
    ENSEMBL proteins: 
     ENSP00000323687   ENSP00000468498   ENSP00000467623  
    Reactome Protein details: Q9C0C9
    Human Recombinant Protein Products for UBE2O: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals UBE2O Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBE2O 


    UBE2O Antibody Products: 
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    Assay Products for UBE2O: 
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    Cloud-Clone Corp. ELISAs for UBE2O 
    Cloud-Clone Corp. CLIAs for UBE2O


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q9C0C9

    ProtoNet protein and cluster: Q9C0C9

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2O for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2O_HUMAN, Q9C0C9
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2O for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2O:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Ube2o (no phenotypes)

    UBE2O for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ube2otm1(KOMP)Mbp for UBE2O

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2O 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2O

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2O 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2O 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2O
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2O (see all 37):
    hsa-miR-4291 hsa-miR-4254 hsa-miR-330-5p hsa-miR-30d hsa-miR-30a hsa-miR-124 hsa-miR-4325 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidUBE2O 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2O
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2O

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of UBE2O

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector: UBE2O (NM_022066)
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    Sirion Biotech Customized lentivirus for stable overexpression of UBE2O 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2O 

    Cell Line
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    Search LifeMap BioReagents cell lines for UBE2O
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2O


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2O About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4        Reactome Pathways for UBE2O
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE2O):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9
    Pathway: Protein modification; protein ubiquitination


    UBE2O for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2O

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/38 Interacting proteins for UBE2O (Q9C0C93 ENSP000003236874) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237071P143733, ENSP000004052294I2D: score=2 STRING: ENSP00000405229
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    ENSG00000234495P143733I2D: score=2 
    TRIM27P143733I2D: score=2 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2O

    4 HMDB Compounds for UBE2O    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2O

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2O gene: 
    NM_022066.3  

    Unigene Cluster for UBE2O:

    Ubiquitin-conjugating enzyme E2O
    Hs.16130  [show with all ESTs]
    Unigene Representative Sequence: NM_022066
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319380(uc002jrl.4 uc002jrm.4 uc002jrn.4) ENST00000587127
    ENST00000586409 ENST00000587581 ENST00000590658 ENST00000586505
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2O
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2O (see all 37):
    hsa-miR-4291 hsa-miR-4254 hsa-miR-330-5p hsa-miR-30d hsa-miR-30a hsa-miR-124 hsa-miR-4325 hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidUBE2O 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2O
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2O
    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2O (see all 9)
    OriGene ORF clones in mouse, rat for UBE2O
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2O (NM_022066)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2O
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2O
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2O 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2O 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2O
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2O
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2O
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2O

    Additional mRNA sequence: 

    AB051521.1 AK000926.1 AK022940.1 AK024657.1 AK025999.1 AK225412.1 AL832432.1 BC004525.2 
    BC022237.1 BC025977.1 BC036820.1 BC051868.2 

    7 DOTS entries:

    DT.415431  DT.100780454  DT.95295490  DT.120980180  DT.92454174  DT.99932745  DT.101975536 

    24/233 AceView cDNA sequences (see all 233):

    BE645208 BF726224 BM928453 AI433415 AI699570 BQ187301 AI698890 AB051521 
    BF593833 AA309174 BM824204 AL832432 AI160123 BP371308 F01395 AW152157 
    BU740780 CD672581 BE670567 AI761115 CD672580 AK025999 BU431783 AI926347 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2O    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
    SP1:                                      -                                                                       -                     
    SP2:                                      -                                                                                             
    SP3:                                                                                                              -                     
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for UBE2O

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2O expression in normal human tissues (normalized intensities)      UBE2O embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGATGTG
    UBE2O Expression
    About this image


    UBE2O expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
             umbilical cord reticulocytes   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal amacrine cell p0   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Brain (Nervous System)
             neocortex   

    See UBE2O Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2O

    SOURCE GeneReport for Unigene cluster: Hs.16130

    UniProtKB/Swiss-Prot: UBE2O_HUMAN, Q9C0C9
    Tissue specificity: Predominantly expressed in skeletal muscle and heart

        SABiosciences Custom PCR Arrays for UBE2O
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2O
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2O

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2O gene from 9/19 species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2o1 , 5 ubiquitin-conjugating enzyme E2O1, 5 88.41(n)1
    94.25(a)1
      11 (81.42 cM)5
    2173421  NM_173755.31  NP_776116.21 
     1165377405 
    chicken
    (Gallus gallus)
    Aves UBE2O1 ubiquitin-conjugating enzyme E2O 76.15(n)
    81.35(a)
      417359  XM_415619.3  XP_415619.3 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2O6
    ubiquitin-conjugating enzyme E2O
    73(a)
    1 ↔ 1
    2(112189610-112286050)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ094425.12   -- 78.65(n)    BJ094425.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK397980.12   -- 70.28(n)    CK397980.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG102541 CG10254 46.21(n)
    34.46(a)
      42793  NM_142913.1  NP_651170.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RAD66
    Ubiquitin-conjugating enzyme (E2), involved in pos...
    22(a)
    1 → many
    VII(393986-394504)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC231 putative ubiquitin-conjugating enzyme E2 23 40.5(n)
    29.66(a)
      816195  NM_127245.2  NP_179284.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g01259001 hypothetical protein 43.49(n)
    34.15(a)
      4326008  NM_001048429.1  NP_001041894.1 


    ENSEMBL Gene Tree for UBE2O (if available)
    TreeFam Gene Tree for UBE2O (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2O gene
    BIRC62  UBE2Z2  
    5 SIMAP similar genes for UBE2O using alignment to 3 protein entries:     UBE2O_HUMAN (see all proteins):
    UBE2Z    UBE2D2    UBE2D3    UBE2A    UBE2N

    UBE2O for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1357 SNPs in UBE2O are shown (see all 1357)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504426001,2
    --74385170(+) GAGTTA/GTGGCA 1 -- int10--------
    rs1451510941,2
    C--74385308(+) ACCACC/TGGCCA 1 -- int10--------
    rs1486705411,2
    C--74385399(+) CGGGT-/GGGGGT 1 -- int10--------
    rs2015436041,2
    C--74385588(+) GAGCC-/ACCACAA 1 -- int10--------
    rs8980841,2
    C,F,H--74385591(-) TTTTTT/GTGTTG 1 -- int111Minor allele frequency- G:0.10NS WA NA CSA 900
    rs1998453091,2
    C--74385591(+) CAACA-/C/CA  
            
    AAAAA
    1 -- int10--------
    rs1433771351,2
    C--74385669(+) CAGTAA/GGCATT 1 -- ut310--------
    rs1390269391,2
    C--74385705(+) GGGAAC/GCACAG 1 -- ut310--------
    rs785607431,2
    F--74385782(+) GGTCCG/AGCTCC 1 -- ut311Minor allele frequency- A:0.01NA 120
    rs1854394391,2
    --74385795(+) CCTCCA/CGCAGC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2O (74385532 - 74449288 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBE2O:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833547CNV Loss17160897
    nsv2145CNV Loss18451855
    nsv833549CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for UBE2O:    About MalaCards
    hepatitis b    hepatitis


    UBE2O for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: UBE2O (1 document)

    Export disorders for UBE2O gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2O gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with UBE2O)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PubMed id 11311559)1, 2, 3 Yokota T.... Emi M. (2001)
    2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Fine-tuning BMP7 signalling in adipogenesis by UBE2O/E 2-230K-mediated monoubiquitination of SMAD6. (PubMed id 23455153)1 Zhang X....Ten Dijke P. (2013)
    6. RNF111/Arkadia is a SUMO-targeted ubiquitin ligase tha t facilitates the DNA damage response. (PubMed id 23751493)1 Poulsen S.L....Mailand N. (2013)
    7. UBE2O negatively regulates TRAF6-mediated NF-kB activa tion by inhibiting TRAF6 polyubiquitination. (PubMed id 23381138)1 Zhang X....ten Dijke P. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. A cohesin-RAD21 interactome. (PubMed id 22145905)1 Panigrahi A.K....Pati D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63893 HGNC: 29554 AceView: E2-230K Ensembl:ENSG00000175931 euGenes: HUgn63893
    ECgene: UBE2O Kegg: 63893 H-InvDB: UBE2O

    (According to HUGE)
    About This Section
    HUGE: KIAA1734

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2O Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2O gene:
    Search GeneIP for patents involving UBE2O

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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