UBE2NL Gene
protein-coding GIFtS: 47
GCID: GC0XP142967
|
|
ubiquitin-conjugating enzyme E2N-like
| |
Aliases
for UBE2NL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2N-Like1 2 | | Epididymis Tissue Protein Li 1742 3 | | Li1742 | | Putative Ubiquitin-Conjugating Enzyme E2 N-Like2 |
Export aliases for UBE2NL gene to outside databasesPrevious GC identifers: GC0XP141661 GC0XP142692 GC0XP142794 GC0XP132071 |
Summaries
for UBE2NL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2NL:
This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91%identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. (provided by RefSeq, Dec 2009)
|
Genomic Views
for UBE2NL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011786.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2NL gene promoter:
Max1 TBP C/EBPbeta AML1a RORalpha2 GATA-1 HSF2 TFIID c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2NL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2NL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq27.3 Ensembl cytogenetic band: Xq27.3 HGNC cytogenetic band: Xq27.3UBE2NL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP142967: view genomic region
(about GC identifiers)
Start:
|
142,967,173 bp from pter |
End:
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142,968,362 bp from pter |
Size:
|
1,190 bases |
Orientation:
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plus strand |
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Proteins
for UBE2NL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UE2NL_HUMAN, Q5JXB2 (See
protein sequence)Recommended Name: Putative ubiquitin-conjugating enzyme E2 N-like Size: 153 amino acids; 17377 Da
Caution: Could be inactive as a ligase. The potential active site Cys residue in position 88 is replaced by a Ser
Secondary accessions: E9KL27Explore the universe of human proteins at neXtProt for UBE2NL: NX_Q5JXB2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5JXB2
UBE2NL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001013007.1
ENSEMBL proteins: ENSP00000359525
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
-- | -- |
UBE2NL for ontologies About GeneDecksing
UBE2NL Antibody Products:
Assay Products for UBE2NL: |
Protein
Domains /
Families
for UBE2NL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2NL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5JXB2ProtoNet protein and cluster: Q5JXB2 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UE2NL_HUMAN, Q5JXB2Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function
for UBE2NL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2NL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2NL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
-- | -- | | GO:0016881 | acid-amino acid ligase activity |
IEA | -- |
UBE2NL for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for UBE2NL:
|
Pathways & Interactions
for UBE2NL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 
Kegg Pathway (Kegg details for UBE2NL):
UBE2NL for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2NL
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for UBE2NL (Q5JXB23 ENSP000003595254) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
-- | -- | | GO:0016567 | protein ubiquitination |
-- | -- |
UBE2NL for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2NL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBE2NL
4 HMDB Compounds for UBE2NL About this table
Search CenterWatch for drugs/clinical trials and news about UBE2NL / UE2NL
|
Transcripts
for UBE2NL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE2NL gene: NM_001012989.1 Unigene Cluster for UBE2NL: Ubiquitin-conjugating enzyme E2N-like Hs.585177 [show with all ESTs]Unigene Representative Sequence: NM_0010129891 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000370494(uc004fca.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2NL
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2NL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBE2NL (NM_001012989) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2NL | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UBE2NL |
Additional cDNA sequence: GU727624.1 3 DOTS entries: DT.100855012 DT.100767810 DT.453669 1 AceView cDNA sequence: BV191502
GeneLoc Exon Structure
|
Expression
for UBE2NL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2NL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCAGAGGCT
About this image
See UBE2NL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2NL
SOURCE GeneReport for Unigene cluster: Hs.585177
UniProtKB/Swiss-Prot: UE2NL_HUMAN, Q5JXB2Tissue specificity: Expressed in epididymis (at protein level)
SABiosciences Custom PCR Arrays for UBE2NL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2NL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UBE2NL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2NL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2NL |
Orthologs
for UBE2NL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2NL gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NFT6_CHICK6 |
ubiquitin-conjugating enzyme E2N (UBC13 homolog, y... |
88(a) |
possible ortholog |
1(46728772-46750488) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
88(a) |
possible ortholog |
5(31465104-31467699) |
zebrafish
(Danio rerio) |
Actinopterygii |
ube2na6ube2nb6 |
ubiquitin-conjugating enzyme E2Nb |
89(a)88(a) |
many ↔ manymany ↔ many |
18(15457186-15472239) 4(1670194-1678947) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG34736ben6 |
bendless |
74(a)74(a) |
many ↔ manymany ↔ many |
2L(14563072-14563726) X(13890387-13893841) |
worm
(Caenorhabditis elegans) |
Secernentea |
ubc-136 |
UBiquitin Conjugating enzyme family member (ubc-13... |
81(a) |
1 → many |
IV(2922593-2925689) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBC13A6UBC13B6 |
ubiquitin-conjugating enzyme E2 36 |
71(a)69(a) |
many ↔ manymany ↔ many |
1(29650454-29652593) 1(5776177-5778484) |
rice
(Oryza sativa) |
Liliopsida |
-- |
ubiquitin-conjugating enzyme, putative, expressed |
73(a) |
1 → many |
1(27667346-27670604) |
ENSEMBL Gene Tree for UBE2NL (if available)
TreeFam Gene Tree for UBE2NL (if available) |
Paralogs
for UBE2NL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE2NL gene
- UBE2T2 UBE2N2
18/22 SIMAP similar genes for UBE2NL using alignment to 1 protein entry: UE2NL_HUMAN(see all similar genes):UBE2N HR6A UBE2A UBE2B UBE2D2 UBE2D3
UBE2D4 UBE2K UBE2T UBE2L3 UBE2D1 UBE2E2
UBE2E3 UBE2I UBE2H UBE2E1 UBE2S UBE2L6
UBE2NL for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UBE2NL
PGOHUM00000245057
|
Genomic Variants
for UBE2NL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBE2NL (142967173 - 142968362 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBE2NL: --
Human Gene Mutation Database (HGMD): UBE2NL
Locus Specific Mutation Databases (LSDB): UBE2NL
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2NL |
|
Disorders
/ Diseases
for UBE2NL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2NL for disorders About GeneDecksing
2  diseases for UBE2NL: About MalaCardsepididymitis malaria
Export disorders for UBE2NL gene to outside databases
|
Publications
for UBE2NL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBE2NL gene integrated from 9 sources:
(articles sorted by number of sources associating them with UBE2NL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
|
External Searches for UBE2NL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing UBE2NL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing UBE2NL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2NL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBE2NL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for UBE2NL gene:
Search GeneIP for patents involving UBE2NL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2NL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | UBE2NL Proteins, Antibodies, CLIAs, and ELISAs |
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