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Aliases for UBE2NL Gene

Aliases for UBE2NL Gene

  • Ubiquitin-Conjugating Enzyme E2N-Like (Gene/Pseudogene) 2 3
  • Epididymis Tissue Protein Li 174 3 4
  • Putative Ubiquitin-Conjugating Enzyme E2 N-Like 3
  • Ubiquitin-Conjugating Enzyme E2N-Like 2
  • Li174 3

External Ids for UBE2NL Gene

Previous GeneCards Identifiers for UBE2NL Gene

  • GC0XP141661
  • GC0XP142692
  • GC0XP142794
  • GC0XP142967
  • GC0XP132071

Summaries for UBE2NL Gene

Entrez Gene Summary for UBE2NL Gene

  • This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. This locus represents a polymorphic pseudogene, where some individuals contain an allele that can encode a full-length protein, while others have a non-functional allele containing a premature stop codon (reference SNP rs237520) that truncates the coding sequence. [provided by RefSeq, Jun 2014]

GeneCards Summary for UBE2NL Gene

UBE2NL (Ubiquitin-Conjugating Enzyme E2N-Like (Gene/Pseudogene)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include acid-amino acid ligase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2NL Gene

Genomics for UBE2NL Gene

Regulatory Elements for UBE2NL Gene

Genomic Location for UBE2NL Gene

Start:
143,884,071 bp from pter
End:
143,885,255 bp from pter
Size:
1,185 bases
Orientation:
Plus strand

Genomic View for UBE2NL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2NL Gene

Proteins for UBE2NL Gene

  • Protein details for UBE2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JXB2-UE2NL_HUMAN
    Recommended name:
    Putative ubiquitin-conjugating enzyme E2 N-like
    Protein Accession:
    Q5JXB2
    Secondary Accessions:
    • E9KL27

    Protein attributes for UBE2NL Gene

    Size:
    153 amino acids
    Molecular mass:
    17377 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBE2NL Gene

Proteomics data for UBE2NL Gene at MOPED

Post-translational modifications for UBE2NL Gene

  • Ubiquitination at Lys10, Lys24, Lys75, and Lys95
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2NL Gene

REFSEQ proteins:

No data available for DME Specific Peptides for UBE2NL Gene

Domains for UBE2NL Gene

Gene Families for UBE2NL Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2NL Gene

Suggested Antigen Peptide Sequences for UBE2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JXB2

UniProtKB/Swiss-Prot:

UE2NL_HUMAN :
  • Q5JXB2
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2NL: view

Function for UBE2NL Gene

Gene Ontology (GO) - Molecular Function for UBE2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019787 ubiquitin-like protein transferase activity IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2NL: view

Phenotypes for UBE2NL Gene

GenomeRNAi human phenotypes for UBE2NL:
genes like me logo Genes that share phenotypes with UBE2NL: view

Animal Model Products

CRISPR Products

miRNA for UBE2NL Gene

miRTarBase miRNAs that target UBE2NL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2NL Gene

Localization for UBE2NL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2NL Gene COMPARTMENTS Subcellular localization image for UBE2NL gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBE2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with UBE2NL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2NL Gene

Pathways for UBE2NL Gene

genes like me logo Genes that share pathways with UBE2NL: view

Pathways by source for UBE2NL Gene

1 KEGG pathway for UBE2NL Gene

Interacting Proteins for UBE2NL Gene

Selected Interacting proteins: Q5JXB2-UE2NL_HUMAN for UBE2NL Gene via I2D

Symbol External ID(s) Details
MEPCE

Gene Ontology (GO) - Biological Process for UBE2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006301 postreplication repair IBA --
GO:0070534 protein K63-linked ubiquitination IBA --
genes like me logo Genes that share ontologies with UBE2NL: view

Compounds for UBE2NL Gene

(4) HMDB Compounds for UBE2NL Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2NL: view

Transcripts for UBE2NL Gene

mRNA/cDNA for UBE2NL Gene

(1) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBE2NL Gene

Ubiquitin-conjugating enzyme E2N-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2NL

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for UBE2NL
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2NL Gene

No ASD Table

Relevant External Links for UBE2NL Gene

GeneLoc Exon Structure for
UBE2NL
ECgene alternative splicing isoforms for
UBE2NL

Expression for UBE2NL Gene

mRNA expression in normal human tissues for UBE2NL Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for UBE2NL Gene

SOURCE GeneReport for Unigene cluster for UBE2NL Gene Hs.585177

mRNA Expression by UniProt/SwissProt for UBE2NL Gene

Q5JXB2-UE2NL_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expressions with UBE2NL: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBE2NL Gene

Orthologs for UBE2NL Gene

This gene was present in the common ancestor of mammals.

Orthologs for UBE2NL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2NL 35
  • 98.69 (n)
  • 97.39 (a)
dog
(Canis familiaris)
Mammalia LOC100856713 35
  • 95.07 (n)
  • 92.96 (a)
Species with no ortholog for UBE2NL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UBE2NL Gene

ENSEMBL:
Gene Tree for UBE2NL (if available)
TreeFam:
Gene Tree for UBE2NL (if available)

Paralogs for UBE2NL Gene

Selected SIMAP similar genes for UBE2NL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBE2NL: view

No data available for Paralogs for UBE2NL Gene

Variants for UBE2NL Gene

Sequence variations from dbSNP and Humsavar for UBE2NL Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs237512 -- 143,882,511(-) GCTCC(A/T)TTTTT upstream-variant-2KB
rs237513 -- 143,882,653(-) ACAAA(C/T)AGTTA upstream-variant-2KB
rs237514 -- 143,883,079(-) GAGAT(A/G)TTATG upstream-variant-2KB
rs237515 -- 143,883,614(+) GAAAA(A/T)TGCCT upstream-variant-2KB
rs237516 -- 143,883,665(+) AGTGC(A/T)GTGGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for UBE2NL Gene

Variant ID Type Subtype PubMed ID
nsv523256 CNV Gain 19592680

Relevant External Links for UBE2NL Gene

HapMap Linkage Disequilibrium report
UBE2NL
Locus Specific Mutation Databases (LSDB)
UBE2NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2NL Gene

Disorders for UBE2NL Gene

No disorders were found for UBE2NL Gene.

No data available for UniProtKB/Swiss-Prot for UBE2NL Gene

Publications for UBE2NL Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 2 3 4
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  3. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PMID: 17643375) Jeronimo C. … Coulombe B. (Mol. Cell 2007) 3
  4. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. (PMID: 19377476) Tarpey P.S. … Stratton M.R. (Nat. Genet. 2009) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for UBE2NL Gene

Sources for UBE2NL Gene

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