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UBE2NL Gene

protein-coding   GIFtS: 50
GCID: GC0XP142967

Ubiquitin-Conjugating Enzyme E2N-Like

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2N-Like1 2
Epididymis Tissue Protein Li 1742 3
Li1742
Putative Ubiquitin-Conjugating Enzyme E2 N-Like2

External Ids:    HGNC: 317101   Entrez Gene: 3898982   Ensembl: ENSG000001020697   UniProtKB: Q5JXB23   

Export aliases for UBE2NL gene to outside databases

Previous GC identifers: GC0XP141661 GC0XP142692 GC0XP142794 GC0XP132071


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2NL Gene:
This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is
91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. (provided by RefSeq, Dec 2009)

GeneCards Summary for UBE2NL Gene:
UBE2NL (ubiquitin-conjugating enzyme E2N-like) is a protein-coding gene. GO annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is UBE2T.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NC_018934.2  NT_011786.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2NL gene promoter:
         Max1   TBP   C/EBPbeta   AML1a   RORalpha2   GATA-1   HSF2   TFIID   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UBE2NL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2NL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq27.3   Ensembl cytogenetic band:  Xq27.3   HGNC cytogenetic band: Xq27.3

UBE2NL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2NL gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP142967:  view genomic region     (about GC identifiers)

Start:
142,967,173 bp from pter      End:
142,968,362 bp from pter
Size:
1,190 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UE2NL_HUMAN, Q5JXB2 (See protein sequence)
Recommended Name: Putative ubiquitin-conjugating enzyme E2 N-like  
Size: 153 amino acids; 17377 Da
Caution: Could be inactive as a ligase. The potential active site Cys residue in position 88 is replaced by a Ser
Secondary accessions: E9KL27

Explore the universe of human proteins at neXtProt for UBE2NL: NX_Q5JXB2

Explore proteomics data for UBE2NL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys10, Lys24, Lys75, Lys95
  • Modification sites at PhosphoSitePlus

  • See UBE2NL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001013007.1  
    ENSEMBL proteins: 
     ENSP00000359525  

    UBE2NL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for UBE2NL

     
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    antibodies-online proteins for UBE2NL 

     
    antibodies-online peptides for UBE2NL

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    LSBio Antibodies in human, mouse, rat for UBE2NL
    antibodies-online antibodies for UBE2NL (10 products) 

    UBE2NL Assay Products:

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    Cloud-Clone Corp. ELISAs for UBE2NL
    Cloud-Clone Corp. CLIAs for UBE2NL
    Search eBioscience for ELISAs for UBE2NL 
    antibodies-online kits for UBE2NL (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q5JXB2

    ProtoNet protein and cluster: Q5JXB2

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UE2NL_HUMAN, Q5JXB2
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2NL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016881acid-amino acid ligase activity IEA--
         
    Find genes that share ontologies with UBE2NL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2NL:
     Proliferating cells 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2NL
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2NL

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2NL:
    hsa-mir-30c-5p (MIRT048011)

    Block miRNA regulation of human, mouse, rat UBE2NL using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UBE2NL:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidUBE2NL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBE2NL
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2NL

    Gene Editing
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2NL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    plasma membrane2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2NL About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with UBE2NL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for UBE2NL):
        Ubiquitin mediated proteolysis

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBE2NL
    Interactions:

        Search GeneGlobe Interaction Network for UBE2NL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2NL (Q5JXB23 ENSP000003595254) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    MAP3K7ENSP000003583354STRING: ENSP00000358335
    TLR4ENSP000003630894STRING: ENSP00000363089
    PCNAENSP000003684384STRING: ENSP00000368438
    RAD18ENSP000002649264STRING: ENSP00000264926
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2NL (UE2NL)

    4 HMDB Compounds for UBE2NL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2NL gene: 
    NM_001012989.2  

    Unigene Cluster for UBE2NL:

    Ubiquitin-conjugating enzyme E2N-like
    Hs.585177  [show with all ESTs]
    Unigene Representative Sequence: NM_001012989
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000370494(uc004fca.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBE2NL using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UBE2NL:
    hsa-miR-27a hsa-miR-128 hsa-miR-3681* hsa-miR-27b
    SwitchGear 3'UTR luciferase reporter plasmidUBE2NL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBE2NL
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2NL
    Clone
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2NL
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UBE2NL
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2NL
      QuantiFast Probe-based Assays in human, mouse, rat UBE2NL

    Additional mRNA sequence: GU727624.1 

    3 DOTS entries:

    DT.100855012  DT.100767810  DT.453669 

    1 AceView cDNA sequence:

    BV191502 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2NL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCAGAGGCT
    UBE2NL Expression
    About this image

    UBE2NL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2NL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.585177

    UniProtKB/Swiss-Prot: UE2NL_HUMAN, Q5JXB2
    Tissue specificity: Expressed in epididymis (at protein level)

        Custom PCR Arrays for UBE2NL
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2NL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE2NL gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia LOC1008567131 ubiquitin-conjugating enzyme E2-24 kDa-like 95.07(n)
    92.96(a)
      100856713  XM_003639509.2  XP_003639557.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2na6
    ube2nb6
    ubiquitin-conjugating enzyme E2Nb
    87(a)
    86(a)
    many ↔ many
    many ↔ many
    18(15457186-15472239) ENSDARG00000008748
    4(1670194-1678947) ENSDARG00000045877
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-136
    Protein UBC-13 (ubc-13) mRNA, complete cds
    79(a)
    1 → many
    IV(2922595-2925691) WBGene00006708
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC136
    Ubiquitin-conjugating enzyme involved in the error...
    63(a)
    1 → many
    IV(629876-630605) YDR092W


    ENSEMBL Gene Tree for UBE2NL (if available)
    TreeFam Gene Tree for UBE2NL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2NL gene
    UBE2T2  UBE2N2  
    Selected SIMAP similar genes for UBE2NL using alignment to 1 protein entry:     UE2NL_HUMAN(see all similar genes):
    UBE2N    HR6A    UBE2A    UBE2B    UBE2D2    UBE2D3
    UBE2D4    UBE2K    UBE2T    UBE2D1    UBE2E2    UBE2L3
    UBE2I    UBE2E3    UBE2H    UBE2S    UBE2E1    UBE2L6

    Find genes that share paralogs with UBE2NL           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UBE2NL
    PGOHUM00000245057


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2NL (see all 78)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899093701,2
    --142920086(+) AATCTA/GTTTTT 1 -- us2k10--------
    rs1821293211,2
    --142920273(+) AAATAA/CCCAAA 1 -- us2k10--------
    rs1868411101,2
    --142920384(+) TTAGGC/TGTCAG 1 -- us2k10--------
    rs2375121,2
    C,F,A,H--142920512(-) GCTCCA/TTTTTT 1 -- us2k1 trp39Minor allele frequency- T:0.40NS EA NA 378
    rs1904354991,2
    --142920594(+) AAGATA/GAAACA 1 -- us2k10--------
    rs2375131,2
    C,A,H--142920654(-) ACAAAT/CAGTTA 1 -- us2k1 tfbs33Minor allele frequency- C:0.00WA NA 6
    rs1819434291,2
    --142920707(+) GTGGAC/GAAAAG 1 -- us2k10--------
    rs1852702861,2
    --142920763(+) AAATAA/TTGTAA 1 -- us2k10--------
    rs1900269001,2
    --142920905(+) GATTTA/CAATTA 1 -- us2k10--------
    rs1825930111,2
    --142920927(+) AAAGGA/GCCACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2NL (142967173 - 142968362 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2NL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv523256CNV Gain19592680

    Human Gene Mutation Database (HGMD): UBE2NL
    Locus Specific Mutation Databases (LSDB): UBE2NL

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2NL
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2NL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with UBE2NL           About GenesLikeMe


    Export disorders for UBE2NL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2NL gene integrated from 10 sources:
    (articles sorted by number of sources associating them with UBE2NL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (Mol. Cell. Proteomics 2010)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)
    4. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PubMed id 22623428)1 Byron A....Humphries M.J. (Proteomics 2012)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    10. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (Mol. Cell 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 389898 HGNC: 31710 AceView: UBE2NL Ensembl:ENSG00000102069 euGenes: HUgn389898
    ECgene: UBE2NL Kegg: 389898 H-InvDB: UBE2NL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2NL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2NL gene:
    Search GeneIP for patents involving UBE2NL

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