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Aliases for UBE2NL Gene

Aliases for UBE2NL Gene

  • Ubiquitin Conjugating Enzyme E2 N Like (Gene/Pseudogene) 2 3 5
  • Epididymis Tissue Protein Li 174 3 4
  • Ubiquitin-Conjugating Enzyme E2N-Like (Gene/Pseudogene) 2
  • Putative Ubiquitin-Conjugating Enzyme E2 N-Like 3
  • Ubiquitin-Conjugating Enzyme E2N-Like 2
  • Ubiquitin Conjugating Enzyme E2N-Like 3
  • Li174 3

External Ids for UBE2NL Gene

Previous GeneCards Identifiers for UBE2NL Gene

  • GC0XP141661
  • GC0XP142692
  • GC0XP142794
  • GC0XP142967
  • GC0XP132071

Summaries for UBE2NL Gene

Entrez Gene Summary for UBE2NL Gene

  • This gene is intronless and encodes a member of the ubiquitin-conjugating enzyme family. The protein product is 91% identical to ubiquitin-conjugating enzyme E2N, a multi-exon gene product. This locus represents a polymorphic pseudogene, where some individuals contain an allele that can encode a full-length protein, while others have a non-functional allele containing a premature stop codon (reference SNP rs237520) that truncates the coding sequence. [provided by RefSeq, Jun 2014]

GeneCards Summary for UBE2NL Gene

UBE2NL (Ubiquitin Conjugating Enzyme E2 N Like (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with UBE2NL include Migraine With Or Without Aura 1. Among its related pathways are Ubiquitin mediated proteolysis and protein ubiquitylation. GO annotations related to this gene include ubiquitin protein ligase binding and ubiquitin-like protein transferase activity. An important paralog of this gene is UBE2N.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2NL Gene

Genomics for UBE2NL Gene

Regulatory Elements for UBE2NL Gene


Genomic Location for UBE2NL Gene

Chromosome:
X
Start:
143,884,071 bp from pter
End:
143,885,255 bp from pter
Size:
1,185 bases
Orientation:
Plus strand

Genomic View for UBE2NL Gene

Genes around UBE2NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2NL Gene

Proteins for UBE2NL Gene

  • Protein details for UBE2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JXB2-UE2NL_HUMAN
    Recommended name:
    Putative ubiquitin-conjugating enzyme E2 N-like
    Protein Accession:
    Q5JXB2
    Secondary Accessions:
    • E9KL27

    Protein attributes for UBE2NL Gene

    Size:
    153 amino acids
    Molecular mass:
    17377 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBE2NL Gene

Post-translational modifications for UBE2NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2NL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBE2NL Gene

Domains & Families for UBE2NL Gene

Gene Families for UBE2NL Gene

Protein Domains for UBE2NL Gene

Suggested Antigen Peptide Sequences for UBE2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JXB2

UniProtKB/Swiss-Prot:

UE2NL_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2NL: view

Function for UBE2NL Gene

Gene Ontology (GO) - Molecular Function for UBE2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2NL: view
genes like me logo Genes that share phenotypes with UBE2NL: view

Animal Model Products

miRNA for UBE2NL Gene

miRTarBase miRNAs that target UBE2NL

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2NL Gene

Localization for UBE2NL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2NL gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 3
plasma membrane 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBE2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with UBE2NL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2NL Gene

Pathways & Interactions for UBE2NL Gene

genes like me logo Genes that share pathways with UBE2NL: view

Pathways by source for UBE2NL Gene

1 BioSystems pathway for UBE2NL Gene
1 KEGG pathway for UBE2NL Gene

Interacting Proteins for UBE2NL Gene

Selected Interacting proteins: Q5JXB2-UE2NL_HUMAN for UBE2NL Gene via IID

Gene Ontology (GO) - Biological Process for UBE2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006301 postreplication repair IBA --
GO:0070534 protein K63-linked ubiquitination IBA --
genes like me logo Genes that share ontologies with UBE2NL: view

No data available for SIGNOR curated interactions for UBE2NL Gene

Drugs & Compounds for UBE2NL Gene

(3) Drugs for UBE2NL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2NL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2NL: view

Transcripts for UBE2NL Gene

mRNA/cDNA for UBE2NL Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBE2NL Gene

Ubiquitin-conjugating enzyme E2N-like:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2NL Gene

No ASD Table

Relevant External Links for UBE2NL Gene

GeneLoc Exon Structure for
UBE2NL
ECgene alternative splicing isoforms for
UBE2NL

Expression for UBE2NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2NL Gene

Protein differential expression in normal tissues from HIPED for UBE2NL Gene

This gene is overexpressed in Heart (40.1), Skin (14.6), and Brain (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UBE2NL Gene



Protein tissue co-expression partners for UBE2NL Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2NL Gene:

UBE2NL

SOURCE GeneReport for Unigene cluster for UBE2NL Gene:

Hs.585177

mRNA Expression by UniProt/SwissProt for UBE2NL Gene:

Q5JXB2-UE2NL_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expression patterns with UBE2NL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBE2NL Gene

Orthologs for UBE2NL Gene

This gene was present in the common ancestor of mammals.

Orthologs for UBE2NL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2NL 34
  • 98.69 (n)
dog
(Canis familiaris)
Mammalia LOC100856713 34
  • 95.07 (n)
Species where no ortholog for UBE2NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UBE2NL Gene

ENSEMBL:
Gene Tree for UBE2NL (if available)
TreeFam:
Gene Tree for UBE2NL (if available)

Paralogs for UBE2NL Gene

Paralogs for UBE2NL Gene

(22) SIMAP similar genes for UBE2NL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBE2NL: view

Variants for UBE2NL Gene

Sequence variations from dbSNP and Humsavar for UBE2NL Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs111632763 -- 143,883,798(+) TAGAG(A/G)CGGGG upstream-variant-2KB
rs112129612 -- 143,883,615(+) AAAAT(-/T)GCCTT upstream-variant-2KB
rs112978561 -- 143,885,561(+) ATTAT(G/T)ATTGT downstream-variant-500B
rs113193576 -- 143,883,770(+) ACGCC(C/T)GGCTA upstream-variant-2KB
rs138291813 -- 143,885,663(+) CTCAT(C/T)TGCCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for UBE2NL Gene

Variant ID Type Subtype PubMed ID
nsv523256 CNV gain 19592680

Variation tolerance for UBE2NL Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.83; 34.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2NL Gene

Human Gene Mutation Database (HGMD)
UBE2NL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2NL Gene

Disorders for UBE2NL Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBE2NL Gene - From: DISEASES

Disorder Aliases PubMed IDs
migraine with or without aura 1
  • migraine
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UBE2NL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2NL
genes like me logo Genes that share disorders with UBE2NL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2NL Gene

Publications for UBE2NL Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 2 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3 64
  5. Proteomic analysis of I+4I^1 integrin adhesion complexes reveals I+-subunit-dependent protein recruitment. (PMID: 22623428) Byron A. … Humphries M.J. (Proteomics 2012) 3 64

Products for UBE2NL Gene

Sources for UBE2NL Gene

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