UBE2N Gene
protein-coding GIFtS: 67
GCID: GC12M093735
|
|
ubiquitin-conjugating enzyme E2N(Previous names: ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13),...)
| |
Aliases
for UBE2N gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2N1 2 | | UbcH132 3 | | UBC131 2 | | EC 6.3.2.193 8 | | UbcH-Ben1 | | MGC84891 | | Ubiquitin-Conjugating Enzyme E2N (Homologous To Yeast UBC13)1 2 | | Bendless-Like Ubiquitin Conjugating Enzyme2 | | Ubiquitin-Conjugating Enzyme E2N (UBC13 Homolog, Yeast)1 2 | | Ubiquitin-Conjugating Enzyme E2 N2 | | Bendless-Like Ubiquitin-Conjugating Enzyme2 3 | | Yeast UBC13 Homolog2 | | Ubiquitin Carrier Protein N2 3 | | BLU3 | | Ubiquitin-Protein Ligase N2 3 | | Ubc133 |
Export aliases for UBE2N gene to outside databasesPrevious GC identifers: GC12M093423 GC12M094324 GC12M092305 GC12M092304 GC12M090868 |
Summaries
for UBE2N gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2N:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, orE1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of theE2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplicationrepair. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088Function: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linkedpolyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediatestranscriptional activation of target genes. Plays a role in the control of progress through the cell cycle anddifferentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNAdamage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upongenotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linkedpolyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of theproteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts inconcert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which inturn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity)
Gene Wiki entry for UBE2N
|
Genomic Views
for UBE2N gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2N gene promoter:
HOXA9 HOXA9B Sp1 Egr-1 XBP-1 Meis-1b Evi-1 Meis-1a ATF Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2N
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2N |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q22UBE2N Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M093735: view genomic region
(about GC identifiers)
Start:
|
93,799,449 bp from pter |
End:
|
93,836,038 bp from pter |
Size:
|
36,590 bases |
Orientation:
|
minus strand |
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Proteins
for UBE2N gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 N Size: 152 amino acids; 17138 Da
Subunit: Heterodimer with UBE2V2. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain);the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with RNF8 and RNF168. Interacts withRNF11. Interacts with the E3 ligases, HLTF and SHPRH; the interactions promote the 'Lys-63'-linked polyubiquitinationof PCNA upon genotoxic stress and lead to DNA repair. Interacts with ARIH2 (via RING-type 2). Interacts with OTUB1;leading to inhibit E2-conjugating activity
Subcellular location: Nucleus. Cytoplasm
6/9 PDB 3D structures from  and Proteopedia  for UBE2N (see all 9):1J7D (3D)
2C2V (3D)
3HCT (3D)
3HCU (3D)
3VON (3D)
4DHI (3D)
Secondary accessions: Q16781 Q53Y81Explore the universe of human proteins at neXtProt for UBE2N: NX_P61088
Post-translational modifications:
Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction with UBE2V21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P61088
4/6 DME Specific Peptides for UBE2N (P61088) (see all 6)
UBE2N Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003339.1
ENSEMBL proteins: ENSP00000316176 ENSP00000449352 ENSP00000450260 ENSP00000447009 ENSP00000448352 Reactome Protein details: P61088
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
UBE2N for ontologies About GeneDecksing
UBE2N Antibody Products:
Assay Products for UBE2N: |
Protein
Domains /
Families
for UBE2N gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2N for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P61088ProtoNet protein and cluster: P61088 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function
for UBE2N gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088Function: The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linkedpolyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediatestranscriptional activation of target genes. Plays a role in the control of progress through the cell cycle anddifferentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNAdamage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upongenotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linkedpolyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of theproteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts inconcert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which inturn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes (By similarity)Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme regulation: Activity is inhibited by binding to OTUB1, which prevents 'Lys-63'-linked polyubiquitinationEnzyme Number (IUBMB): EC 6.3.2.191 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2N (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2N
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: UBE2N (NM_003348) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2N | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2N |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2N |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
UBE2N for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for UBE2N:
Animal Models:
Mouse knock-out Ube2ntm2Aki for UBE2N
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Ube2n):
UBE2N for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBE2N gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | | | 3 | Antigen processing: Ubiquitination & Proteasome degradation | | | 4 | Immune System | | | 5 | Immune response_IL-1 signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for UBE2N
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2N
3 
Cell Signaling Technology (CST) Pathways for UBE2N
3  GeneGo (Thomson Reuters) Pathways for UBE2N
1  BioSystems Pathway for UBE2N
5/38 
Reactome Pathways for UBE2N (see all 38)
1 
Kegg Pathway (Kegg details for UBE2N):
UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088Pathway: Protein modification; protein ubiquitination
UBE2N for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2N
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/892 Interacting proteins for UBE2N (P610881, 2, 3 ENSP000003161764) via UniProtKB, MINT, STRING, and/or I2D (see all 892)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| HLTF | Q145272, 3, ENSP000003089444 | MINT-7945693 MINT-7947479 I2D:
score=2 STRING: ENSP00000308944 | | RNF168 | Q8IYW51, 3, ENSP000003208984 | EBI-1052908,EBI-914207 I2D:
score=2 STRING: ENSP00000320898 | | UBE2V2 | Q158191, 3, ENSP000003264734 | EBI-1052908,EBI-714329 I2D:
score=15 STRING: ENSP00000326473 | | HSPA8 | P111422, 3 | MINT-7945693 MINT-7947479 I2D:
score=1 | | POLR1C | O151602, 3 | MINT-7945693 MINT-7947479 I2D:
score=1 |
About this table
Gene Ontology (GO): 5/27 biological process terms (GO ID links to tree view) (see all 27): About this table
UBE2N for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2N gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBE2N
4 HMDB Compounds for UBE2N About this table
Search CenterWatch for drugs/clinical trials and news about UBE2N
|
Transcripts
for UBE2N gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE2N gene: NM_003348.3 Unigene Cluster for UBE2N: Ubiquitin-conjugating enzyme E2N Hs.524630 [show with all ESTs]Unigene Representative Sequence: NM_0033486 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000548946 ENST00000318066(uc001tcp.3) ENST00000550657 ENST00000549833
ENST00000549490 ENST00000552442
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2N (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2N
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: UBE2N (NM_003348) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2N | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2N |
Additional cDNA sequence: AL110140.1 BC000396.2 BC003365.1 BC108704.1 BT006873.1 D83004.1 24/25 DOTS entries (see all 25): DT.453669 DT.100855012 DT.95269516 DT.100668076 DT.75194839 DT.100853696 DT.121176170 DT.100668086 DT.100839675 DT.95269519 DT.100668079 DT.100668083 DT.100668084 DT.100767810 DT.121176181 DT.92453396 DT.95118319 DT.95219528 DT.95296694 DT.100870368 DT.121176146 DT.121176159 DT.121176172 DT.121304279 24/546 AceView cDNA sequences (see all 546): BM126299 AU280192 BQ774918 BQ011070 AU125145 BM126860 AW078551 C00403 BQ072800 CR594944 AI360468 AV726804 BM462651 CR592204 BU626173 AA081050 BQ012933 AW572194 BM977429 CB044509 BI829065 BM449746 AA910925 CA310015
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2N (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBE2N
|
Expression
for UBE2N gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2N expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See UBE2N Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2N
SOURCE GeneReport for Unigene cluster: Hs.524630
SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2N:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2N
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2N | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2N | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2N | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2N |
Orthologs
for UBE2N gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2N gene from 9/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
F1NFT6_CHICK6 |
ubiquitin-conjugating enzyme E2N (UBC13 homolog, y... |
95(a) |
possible ortholog |
1(46728772-46750488) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
95(a) |
possible ortholog |
5(31465104-31467699) |
African clawed frog
(Xenopus laevis) |
Amphibia |
ube2n-prov2 |
ubiquitin-conjugating enzyme E2N |
86.38(n) |
|
BC053797.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.55122 |
Danio rerio mRNA similar to ubiquitin-conjugating enzyme more |
85.68(n) |
|
BC044461.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
BG:DS01486.13
ben1 |
ubiquitin cycle ubiquitin conjugating enzyme3
bendless1 |
83(a)
(best of 2)3
69.54(n)1
80.13(a)1 |
|
35B33
323581 NM_001169281.11 NP_001162752.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ubc-136 |
UBiquitin Conjugating enzyme family member (ubc-13... |
87(a) |
1 → many |
IV(2922593-2925689) |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UBC13(YDR092W)4
UBC131 |
Ubiquitin-conjugating enzyme involved in the error-free more4
Ubc13p1 |
65.54(n)1
70.27(a)1 |
|
4(629876-630605)4
8516661, 4 NP_010377.31 NP_010377.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBC361 |
ubiquitin-conjugating enzyme E2 36 |
66.67(n)
80.27(a) |
|
838260 NM_101550.3 NP_564011.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.143542 |
Oryza sativa (japonica cultivar-group) ubiquitin-conjugating more |
74.09(n) |
|
NM_191984.1 |
ENSEMBL Gene Tree for UBE2N (if available)
TreeFam Gene Tree for UBE2N (if available) |
Paralogs
for UBE2N gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE2N gene
- UBE2T2 UBE2NL2
18/31 SIMAP similar genes for UBE2N using alignment to 5 protein entries: UBE2N_HUMAN (see all proteins)
(see all similar genes):UBE2NL UBE2H HIP2 UBE2D2 UBE2A UBE2T
UBE2D3 HR6A UBE2F UBE2E3 UBE2D4 UBE2L3
UBE2B UBE2D1 UBE2E2 UBE2L6 UBE2G1 UBE2I
UBE2N for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for UBE2N
PGOHUM00000247738 PGOHUM00000240575 PGOHUM00000245771 PGOHUM00000261514
|
Genomic Variants
for UBE2N gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBE2N (93799449 - 93836038 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBE2N: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2N |
|
Disorders
/ Diseases
for UBE2N gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2N for disorders About GeneDecksing
OMIM gene information: 603679
OMIM disorders: --
13  diseases for UBE2N: About MalaCardslimb-girdle muscular dystrophy human t-cell leukemia virus type 1 muscular dystrophy leukemia/lymphoma
riddle syndrome leukemia/lymphoma, t-cell chronic lymphocytic leukemia lymphocytic leukemia
t-cell leukemia leukemia breast cancer schizophrenia
malaria
Human Genome Epidemiology (HuGE) Navigator: UBE2N (2 documents)
Export disorders for UBE2N gene to outside databases
|
Publications
for UBE2N gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for UBE2N gene, integrated from 9 sources (see all 149):
(articles sorted by number of sources associating them with UBE2N) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. (PubMed id 8902611)1, 2, 3 Yamaguchi T....Kato S. (1996)
- The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. (PubMed id 16215985)1, 2, 9 Plans V.... Thomson T.M. (2006)
- ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity. (PubMed id 16112642)1, 2, 9 Takeuchi T. and Yokosawa H. (2005)
- The ubiquitin ligase Triad1 inhibits myelopoiesis thr ough UbcH7 and Ubc13 interacting domains. (PubMed id 19340006)1, 2, 9 Marteijn J.A....van der Reijden B.A. (2009)
- Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes. (PubMed id 18615712)1, 2, 9 Scheper J....Thomson T.M. (2009)
- The mechanism of OTUB1-mediated inhibition of ubiquiti nation. (PubMed id 22367539)1, 2 Wiener R....Wolberger C. (2012)
- Molecular insights into the function of RING finger (R NF)-containing proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent ubiquitylation . (PubMed id 22589545)1, 2 Campbell S.J....Glover J.N. (2012)
- TRIM5 is an innate immune sensor for the retrovirus c apsid lattice. (PubMed id 21512573)1, 2 Pertel T....Luban J. (2011)
- Non-canonical inhibition of DNA damage-dependent ubiq uitination by OTUB1. (PubMed id 20725033)1, 2 Nakada S....Durocher D. (2010)
- The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. (PubMed id 19203578)1, 2 Stewart G.S....Durocher D. (2009)
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External Searches for UBE2N gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing UBE2N gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing UBE2N gene
(According to HUGE)
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Specialized Databases showing UBE2N gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for UBE2N gene:
Search GeneIP for patents involving UBE2N
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UBE2N gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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