Aliases for UBE2N Gene
- Ubiquitin-Conjugating Enzyme E2N 2 3
- Ubiquitin-Conjugating Enzyme E2N (Homologous To Yeast UBC13) 2 3
- Ubiquitin-Conjugating Enzyme E2N (UBC13 Homolog, Yeast) 2 3
- Bendless-Like Ubiquitin-Conjugating Enzyme 3 4
- E2 Ubiquitin-Conjugating Enzyme N 3 4
- Ubiquitin Carrier Protein N 3 4
- Ubiquitin-Protein Ligase N 3 4
- UbcH13 3 4
- UBC13 3 4
- Bendless-Like Ubiquitin Conjugating Enzyme 3
External Ids for UBE2N Gene
Previous GeneCards Identifiers for UBE2N Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2N Gene
UBE2N (Ubiquitin-Conjugating Enzyme E2N) is a Protein Coding gene. Diseases associated with UBE2N include ciliary dyskinesia, primary, 22. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include poly(A) RNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2T.
UniProtKB/Swiss-Prot for UBE2N Gene
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical Lys-63-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the Lys-63-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the Lys-63-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate Lys-63-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.
The ubiquitin (Ub)/Ub-like (Ubl) conjugating enzymes are a conserved family of ligases which mediate the conjugation of Ub and Ubl proteins to target substrates. There have been 35 E2 enzymes identified in the human genome to date.