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UBE2N Gene

protein-coding GIFtS: 63

GC12M092304

ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)
(Previous name: ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BLU ^³
EC 6.3.2.19 ^³
MGC131857 ^²
MGC8489 ^¹, ²
UBC13 ^¹, ²
Ubc13 ^³
UbcH-ben ^¹, ²

Descriptions
Bendless-like ubiquitin-conjugating enzyme ^³
Ubiquitin carrier protein N ^², ³
Ubiquitin-protein ligase N ^², ³
bendless-like ubiquitin conjugating enzyme ^²
ubiquitin-conjugating enzyme E2N ^²
ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast) ^²
ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13) ^¹, ²
yeast UBC13 homolog ^²

External Ids
HGNC: 12492¹
Entrez Gene: 7334²
UniProtKB: P61088³
Ensembl: ENSG00000177889⁷

Search outside databases for aliases for UBE2N gene

Previous GC identifers: GC12M093423 GC12M094324 GC12M093735 GC12M092305

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2N:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication

repair. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088

Function: The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin

chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein

degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role

in the control of progress through the cell cycle and differentiation. Plays a role in the

error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts

together with the E3 ligase SHPRH in the poly-ubiquitination of PCNA 'Lys-164' upon genotoxic

stress, which is required for DNA repair

Gene Wiki entry for UBE2N

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2N gene

Entrez Gene cytogenetic band: 12q22 Ensembl cytogenetic band: 12q22 HGNC cytogenetic band: 12q22

UBE2N Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M092304: (about GC identifiers)

Start:	92,326,219 bp from pter
End:	92,360,157 bp from pter
Size:	33,939 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_019546.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 N

Size: 152 amino acids; 17138 Da

Subunit: Heterodimer with UBE2V2. Interacts with RNF8, RNF168 and SHPRH

PDB structure from and Proteopedia :

1J7D (3D)

2C2V (3D)

Secondary accessions: Q16781 Q53Y81

Post-translational modifications:

Conjugation to ISG15 impairs formation of the thioester bond with ubiquitin but not interaction

with UBE2V2¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003339.1

ENSEMBL proteins:

ENSP00000316176 ENSP00000376841

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2N
	Recombinant Proteins from Abcam (Ube2N)
	Human Recombinant Proteins from Abnova (UBE2N)

OriGene Purified Recombinant Human Protein: UBE2N

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	16129784
GO:0005737	cytoplasm	TAS	16130169
GO:0031372	UBC13-MMS2 complex	IDA	16129784

About this table

Antibodies for UBE2N:

	Invitrogen Antibodies for UBE2N
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE2N
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for UBE2N (ubc13)
	Antibodies from Abcam (Ube2N), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2N)
	Novus Biologicals Antibodies for UBE2N

Assays for UBE2N:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2N

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61088

ProtoNet protein and cluster: P61088

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2N)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2N)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003348

Applied Biosystems Silencer® siRNAs for UBE2N

Sigma-Aldrich siRNA and siRNA Panels for UBE2N

Sigma-Aldrich shRNA Panels and shRNA for UBE2N

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2N
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003348
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003348
untagged cDNA clone in CMV expression vector: NM_003348

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003348

UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088

Function: The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin

chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein

degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role

in the control of progress through the cell cycle and differentiation. Plays a role in the

error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts

together with the E3 ligase SHPRH in the poly-ubiquitination of PCNA 'Lys-164' upon genotoxic

stress, which is required for DNA repair

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Ube2n):

hematopoietic system

immune system

lethality-prenatal/perinatal

normal

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005515	protein binding	IPI	11473255
GO:0016874	ligase activity	IEA	--
GO:0043130	ubiquitin binding	IDA	16122702

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2N (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway
NF-&kappa
Hypoxia Signaling in the Cardiovascular System

GeneDecks UBE2N for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UBE2N_HUMAN, P61088

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2N

5/37 Interacting proteins for UBE2N (ENSP00000316176³ P61088^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2V2	Q15819¹	STRING (score=.999) EBI-1052908, EBI-714329
RNF168	Q8IYW5¹	EBI-1052908, EBI-914207
RNF11	Q9Y3C5²	MINT-60857
UBE2V1	Q13404²	MINT-50197
TMEM189	ENSP00000344166³	STRING (score=.999)

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5/14 Gene Ontology (GO) biological process terms (links to tree view) (see all 14 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000724	double-strand break repair via homologous recombination	IMP	17349954
GO:0000729	DNA double-strand break processing	IMP	17349954
GO:0006301	postreplication repair	IMP	17349954
GO:0006508	proteolysis	TAS	8902611
GO:0006974	response to DNA damage stimulus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2N

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2N)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2N)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003348

Sigma-Aldrich siRNA and siRNA Panels for UBE2N

Sigma-Aldrich shRNA Panels and shRNA for UBE2N

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003348

REFSEQ mRNAs for UBE2N gene:

NM_003348.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003348

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003348
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003348
                                 untagged cDNA clone in CMV expression vector: NM_003348

Additional cDNA sequence:

AL110140.1 BC000396.2 BC003365.1 BC108704.1 BT006873.1 CR592204.1 CR594944.1 CR595779.1

CR598187.1 CR599550.1 CR620151.1 D83004.1

24/25 DOTS entries (see all 25 ):

DT.453669 DT.100855012 DT.95269516 DT.100668076 DT.75194839 DT.100853696 DT.121176170 DT.100668086

DT.100839675 DT.95269519 DT.100668083 DT.100668084 DT.100767810 DT.95118319 DT.95195219 DT.95219528

DT.95296694 DT.100668079 DT.100870368 DT.121176146 DT.121176159 DT.121176172 DT.121176181 DT.121304279

24/546 AceView cDNA sequences (see all 546 ):

BQ011070 AA420971 CR595779 BG432626 AA910925 AI674573 AI492085 BM698142

CF130960 BE207615 BG170721 AI287273 BU784291 BE262841 AI420149 AU125145

C00403 BM920802 BU625672 CB108473 BM463602 BU732178 AA573187 CR599550

highest scoring ESTs for UBE2N:

D83004 AA058816 AA149476 AA308807 AA325028 AA412631 AA471310 AI343433 AL137979 AU077052

Unigene Cluster for UBE2N:

Ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)

Hs.524630 [show with all ESTs]

Unigene Representative Sequence: NM_003348

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2N (see all 6 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	·	7d
SP1:											-
SP2:							-		-		-
SP3:							-		-		-				-
SP4:							-		-
SP5:							-		-		-

About this scheme

ECgene alternative splicing isoforms for UBE2N

2 Ensembl transcripts including schematic representations:

ENST00000318066 ENST00000393133

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2N expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2N

¹ / ² / ³

8 probe-sets matching UBE2N gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36604_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.03	D83004	1.00	1.00	1.00	1
1660_at²^{, 3}	U95-A	2	1.00	0.75	0.96	0.97	D83004	1.00	1.00	1.00	1
212751_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BG290646	0.40	1.00	0.76	1
201524_x_at²^{, 3}	U133-A	2	1.00	0.82	--	--	NM_003348	0.60	1.00	0.82	1
201523_x_at²^{, 3}	U133-A	3	1.00	0.55	--	--	BE262760	0.80	1.00	0.91	1
212751_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201524_x_at²	U133Plus2	2	1.00	0.82	--	--	--	--	--	--	--
201523_x_at²	U133Plus2	3	1.00	0.55	--	--	--	--	--	--	--

GeneDecks UBE2N for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.524630
Expression variation in blood from EXPOLDB for UBE2N

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2N gene from 5/28 species (see all 28 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2N¹	--	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	98.03(n) 99.34(a)	609136 XM_534272.2 XP_534272.1
chimpanzee (Pan troglodytes)	UBE2N¹	--	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	100(n) 100(a)	452125 XM_001139171.1 XP_001139171.1
cow (Bos taurus)	UBE2N¹	--	ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)	98.25(n) 100(a)	541130 NM_001076258.1 NP_001069726.1
rat (Rattus norvegicus)	Ube2n¹	--	ubiquitin-conjugating enzyme E2N	97.15(n) 99.34(a)	116725 NM_053928.2 NP_446380.1
mouse (Mus musculus)	Ube2n^{1, 5}	10⁵	ubiquitin-conjugating enzyme E2N^{1, 5}	97.59(n)¹ 100(a)¹	93765¹ NM_080560.3¹ NP_542127.1¹ AA866989⁵ AI413942⁵ (see all 21)

About this table Species with no ortholog for UBE2N

ENSEMBL Gene Tree for UBE2N

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for UBE2N gene

UBE2K² UBE2T² UBE2NL²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/189 NCBI SNPs in UBE2N are shown (see all 189 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 64)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3759169^1,2	C,F,H	92361231(+)	`AATAGT/CGCACT`	1	--	ng3¹		3		EA WA	298
--	rs643247^1,2	F,H	92327279(+)	`AAAAAT/AATTTT`	1	--	ut3¹		7		EA NA MN EU	528
--	rs3952508^1,2	A,C	92362116(-)	`caaaaA/Caaaac`	1	--	ng3¹		0	--	--	--	--
	rs7342330^1,2	C,H	92361715(+)	`tcactC/Tcaagt`	1	--	ng3¹		1		EU	120
	rs12821933^1,2	H	92326080(+)	`AAGTGA/TGATTC`	1	--	ng5¹		4		EU EA WA	414
--	rs11558876^1,2	H	92329100(-)	`TTCCCC/GCTTTG`	1	P/R	mis¹ trp³		4		EU EA WA	398
--	rs643258^1,2	H	92327286(+)	`TTTTAC/TTAAAA`	1	--	ut3¹		5		MN EU EA WA	602
--	rs12822459^1,2	H	92326129(+)	`CCCAAG/AAATTG`	1	--	ng5¹		4		EU EA WA	418
	rs11107016^1,2	H	92326474(+)	`ACTGGC/TTACAT`	1	--	ut3¹ ese³		4		EU EA WA	420
--	rs12821957^1,2	H	92326128(+)	`GCCCAA/TGAATT`	1	--	ng5¹		4		EU EA WA	420

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HapMap Linkage Disequilibrium images for UBE2N (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603679

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/52 PubMed articles for UBE2N gene (see all 52 ):

Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. (PubMed id 8902611)^{2, 3, 4} Yamaguchi T....Kato S. (1996)
The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation. (PubMed id 16215985)^{1, 3, 4} Plans V.... Thomson T.M. (2006)
ISG15 modification of Ubc13 suppresses its ubiquitin-conjugating activity. (PubMed id 16112642)^{1, 3, 4} Takeuchi T. and Yokosawa H. (2005)
ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin. (PubMed id 16122702)^{3, 4} Zou W.... Zhang D.-E. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains. (PubMed id 14562038)^{3, 4} Bothos J.... Halazonetis T.D. (2003)
Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13. (PubMed id 11473255)^{3, 4} Moraes T.F.... Ellison M.J. (2001)
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. (PubMed id 10089880)^{3, 4} Hofmann R.M. and Pickart C.M. (1999)
A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex. (PubMed id 15749714)^{1, 3} Pastushok L....Xiao W. (2005)
The human T-cell leukemia virus type 1 Tax oncoprotein requires the ubiquitin-conjugating enzyme Ubc13 for NF-kappaB activation. (PubMed id 17942533)^{1, 3} Shembade N....Harhaj E.W. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7334	HGNC: 12492	AceView: UBE2N	Ensembl:ENSG00000177889	euGenes: HUgn7334
ECgene: UBE2N	H-InvDB: UBE2N

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for UBE2N	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE2N
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE2N:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2N-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2N		Antibodies for UBE2N
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE2N		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBE2N)
	Antibodies (UBE2N)
	Chimera RNAi (UBE2N)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for UBE2N (ubc13)

	Recombinant Proteins (Ube2N)
	Antibodies (Ube2N)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

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	Assays/Proteins for UBE2N
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Antibodies for UBE2N

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UBE2N Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for UBE2N

Summaries
for UBE2N

Genomic Location
for UBE2N

Proteins
for UBE2N

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Families
for UBE2N

Gene Function
for UBE2N

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for UBE2N

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Transcripts
for UBE2N

Expression
for UBE2N

Orthologs
for UBE2N

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for UBE2N

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for UBE2N

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2N Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor UBE2N

Summariesfor UBE2N

Genomic Locationfor UBE2N

Proteinsfor UBE2N

Protein Domains/Familiesfor UBE2N

Gene Functionfor UBE2N

Pathways & Interactionsfor UBE2N

Drugs & Compoundsfor UBE2N

Transcriptsfor UBE2N

Expression for UBE2N

Orthologsfor UBE2N

Paralogsfor UBE2N

SNPs/Variantsfor UBE2N

Disorders & Mutationsfor UBE2N

Medical Newsfor UBE2N

Publicationsfor UBE2N

Search for UBE2N

Genome Databases showing UBE2N

Other Databases showing UBE2N

Specialized Databases showing UBE2N

Licensable Technologiesfor UBE2N

Servicesfor UBE2N

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2N

Summaries
for UBE2N

Genomic Location
for UBE2N

Proteins
for UBE2N

Protein Domains/
Families
for UBE2N

Gene Function
for UBE2N

Pathways & Interactions
for UBE2N

Drugs & Compounds
for UBE2N

Transcripts
for UBE2N

Expression
for UBE2N

Orthologs
for UBE2N

Paralogs
for UBE2N

SNPs/Variants
for UBE2N

Disorders & Mutations
for UBE2N

Medical News
for UBE2N

Publications
for UBE2N

Licensable Technologies
for UBE2N

Services
for UBE2N