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Aliases for UBE2M Gene

Aliases for UBE2M Gene

  • Ubiquitin Conjugating Enzyme E2 M 2 3
  • Ubiquitin-Conjugating Enzyme E2M (UBC12 Homolog, Yeast) 2 3
  • Ubiquitin Conjugating Enzyme E2M 3 5
  • NEDD8 Carrier Protein 3 4
  • NEDD8 Protein Ligase 3 4
  • UBC12 3 4
  • Ubiquitin-Conjugating Enzyme E2M (Homologous To Yeast UBC12) 2
  • Ubiquitin-Conjugating Enzyme E2 M 4
  • Ubiquitin-Conjugating Enzyme E2M 2
  • Ubiquitin Carrier Protein M 3
  • Ubiquitin-Protein Ligase M 3
  • Yeast UBC12 Homolog 3
  • EC 6.3.2.- 4
  • EC 6.3.2 63
  • UBC-RS2 3
  • HUbc12 3

External Ids for UBE2M Gene

Previous GeneCards Identifiers for UBE2M Gene

  • GC19M059965
  • GC19M059521
  • GC19M063742
  • GC19M063758
  • GC19M059067

Summaries for UBE2M Gene

Entrez Gene Summary for UBE2M Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2M Gene

UBE2M (Ubiquitin Conjugating Enzyme E2 M) is a Protein Coding gene. Diseases associated with UBE2M include familial hypertension. Among its related pathways are Signaling by GPCR and Immune System. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F.

UniProtKB/Swiss-Prot for UBE2M Gene

  • Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

Gene Wiki entry for UBE2M Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2M Gene

Genomics for UBE2M Gene

Regulatory Elements for UBE2M Gene

Promoters for UBE2M Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2M on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UBE2M gene promoter:

Genomic Location for UBE2M Gene

Chromosome:
19
Start:
58,555,712 bp from pter
End:
58,558,976 bp from pter
Size:
3,265 bases
Orientation:
Minus strand

Genomic View for UBE2M Gene

Genes around UBE2M on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2M Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2M Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2M Gene

Proteins for UBE2M Gene

  • Protein details for UBE2M Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61081-UBC12_HUMAN
    Recommended name:
    NEDD8-conjugating enzyme Ubc12
    Protein Accession:
    P61081
    Secondary Accessions:
    • O76069
    • Q8VC50

    Protein attributes for UBE2M Gene

    Size:
    183 amino acids
    Molecular mass:
    20900 Da
    Quaternary structure:
    • Interacts with UBA3, DCUN1D1 and RBX1.

    Three dimensional structures from OCA and Proteopedia for UBE2M Gene

neXtProt entry for UBE2M Gene

Proteomics data for UBE2M Gene at MOPED

Selected DME Specific Peptides for UBE2M Gene

Post-translational modifications for UBE2M Gene

  • The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
  • Ubiquitination at Lys 3, Lys 8, Lys 36, Lys 75, and Lys 81
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2M Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2M (UBE2M)

Domains & Families for UBE2M Gene

Gene Families for UBE2M Gene

Protein Domains for UBE2M Gene

Suggested Antigen Peptide Sequences for UBE2M Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61081

UniProtKB/Swiss-Prot:

UBC12_HUMAN :
  • Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8.
  • Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
Domain:
  • Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex simultaneously for optimal transfer of NEDD8.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily.
genes like me logo Genes that share domains with UBE2M: view

Function for UBE2M Gene

Molecular function for UBE2M Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine.
UniProtKB/Swiss-Prot Function:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation.

Enzyme Numbers (IUBMB) for UBE2M Gene

Gene Ontology (GO) - Molecular Function for UBE2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 9694792
GO:0016874 ligase activity IEA --
GO:0018169 ribosomal S6-glutamic acid ligase activity IDA 15361859
GO:0019788 NEDD8 transferase activity IDA 19250909
genes like me logo Genes that share ontologies with UBE2M: view
genes like me logo Genes that share phenotypes with UBE2M: view

Animal Models for UBE2M Gene

MGI Knock Outs for UBE2M:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2M

miRNA for UBE2M Gene

miRTarBase miRNAs that target UBE2M

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2M Gene

Localization for UBE2M Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2M Gene COMPARTMENTS Subcellular localization image for UBE2M gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 3

Gene Ontology (GO) - Cellular Components for UBE2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBE2M: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2M Gene

Pathways & Interactions for UBE2M Gene

genes like me logo Genes that share pathways with UBE2M: view

Pathways by source for UBE2M Gene

UniProtKB/Swiss-Prot P61081-UBC12_HUMAN

  • Pathway: Protein modification; protein neddylation.

Gene Ontology (GO) - Biological Process for UBE2M Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination TAS 9694792
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS --
GO:0038061 NIK/NF-kappaB signaling TAS --
GO:0043525 positive regulation of neuron apoptotic process IEA --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with UBE2M: view

No data available for SIGNOR curated interactions for UBE2M Gene

Drugs & Compounds for UBE2M Gene

(3) Drugs for UBE2M Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2M Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2M: view

Transcripts for UBE2M Gene

Unigene Clusters for UBE2M Gene

Ubiquitin-conjugating enzyme E2M:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2M Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: -
SP3:
SP4:

Relevant External Links for UBE2M Gene

GeneLoc Exon Structure for
UBE2M
ECgene alternative splicing isoforms for
UBE2M

Expression for UBE2M Gene

mRNA expression in normal human tissues for UBE2M Gene

Protein differential expression in normal tissues from HIPED for UBE2M Gene

This gene is overexpressed in Peripheral blood mononuclear cells (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2M Gene



SOURCE GeneReport for Unigene cluster for UBE2M Gene Hs.406068

genes like me logo Genes that share expression patterns with UBE2M: view

Protein tissue co-expression partners for UBE2M Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2M Gene

Orthologs for UBE2M Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2M Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2M 35
  • 96.54 (n)
  • 100 (a)
UBE2M 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2M 35
  • 97.27 (n)
  • 100 (a)
UBE2M 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2m 35
  • 94.35 (n)
  • 100 (a)
Ube2m 16
Ube2m 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2M 35
  • 99.77 (n)
  • 100 (a)
UBE2M 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2m 35
  • 94.9 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves UBE2M 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2M 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75750 35
ube2m 35
  • 81.42 (n)
  • 97.81 (a)
zebrafish
(Danio rerio)
Actinopterygii wu:fb58e05 35
  • 81.24 (n)
  • 91.26 (a)
wufb58e05 35
fruit fly
(Drosophila melanogaster)
Insecta CG7375 37
  • 75 (a)
Ubc12 35
  • 73.56 (n)
  • 76.54 (a)
Ubc12 36
  • 73 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005916 35
  • 70.13 (n)
  • 80.87 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL035C 35
  • 55.49 (n)
  • 41.9 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17248g 35
  • 47.25 (n)
  • 38.46 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC12 35
  • 50.93 (n)
  • 43.33 (a)
UBC12 36
  • 37 (a)
OneToMany
UBC12 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G18600 35
  • 59.89 (n)
  • 63.19 (a)
soybean
(Glycine max)
eudicotyledons Gma.17973 35
barley
(Hordeum vulgare)
Liliopsida Hv.3803 35
rice
(Oryza sativa)
Liliopsida Os.14656 35
Os08g0374100 35
  • 59.52 (n)
  • 61.54 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.3716 35
corn
(Zea mays)
Liliopsida Zm.4335 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1924 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03610 35
  • 62.3 (n)
  • 56.83 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc12 35
  • 54.17 (n)
  • 51.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4912 36
  • 62 (a)
OneToOne
Species with no ortholog for UBE2M:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for UBE2M Gene

ENSEMBL:
Gene Tree for UBE2M (if available)
TreeFam:
Gene Tree for UBE2M (if available)

Paralogs for UBE2M Gene

Paralogs for UBE2M Gene

Pseudogenes.org Pseudogenes for UBE2M Gene

genes like me logo Genes that share paralogs with UBE2M: view

Variants for UBE2M Gene

Sequence variations from dbSNP and Humsavar for UBE2M Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs370510222 -- 58,557,140(+) GGGCA(A/G)GTTCA reference, synonymous-codon
rs200667382 -- 58,557,161(+) GTCTG(G/T)GTTTG intron-variant
rs201857688 -- 58,557,152(+) CTCGT(C/T)TATGT reference, missense
rs539036249 -- 58,557,169(+) TTGGG(C/T)AGCAG intron-variant
rs566710013 -- 58,557,165(+) GGGTT(C/T)GGGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2M Gene

Variant ID Type Subtype PubMed ID
nsv515731 CNV Gain+Loss 19592680
nsv828657 CNV Gain 20364138
nsv912546 CNV Loss 21882294
dgv4032n71 CNV Loss 21882294

Variation tolerance for UBE2M Gene

Residual Variation Intolerance Score: 49.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 5.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2M Gene

HapMap Linkage Disequilibrium report
UBE2M

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2M Gene

Disorders for UBE2M Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBE2M Gene - From: GeneCards

Disorder Aliases PubMed IDs
familial hypertension
  • genetic hypertension
- elite association - COSMIC cancer census association via MalaCards
Search UBE2M in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBE2M

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2M
genes like me logo Genes that share disorders with UBE2M: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2M Gene

Publications for UBE2M Gene

  1. A new NEDD8-ligating system for cullin-4A. (PMID: 9694792) Osaka F. … Kato S. (Genes Dev. 1998) 2 3 4 67
  2. The mechanism of poly-NEDD8 chain formation in vitro. (PMID: 19245792) Ohki Y. … Chiba T. (Biochem. Biophys. Res. Commun. 2009) 3 23
  3. A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. (PMID: 10828074) Wada H. … Kamitani T. (J. Biol. Chem. 2000) 3 23
  4. The ubiquitin-associated (UBA) domain of SCCRO/DCUN1D1 protein serves as a feedback regulator of biochemical and oncogenic activity. (PMID: 25411243) Huang G. … Singh B. (J. Biol. Chem. 2015) 3
  5. Src phosphorylation converts Mdm2 from a ubiquitinating to a neddylating E3 ligase. (PMID: 25624478) Batuello C.N. … Mayo L.D. (Proc. Natl. Acad. Sci. U.S.A. 2015) 3

Products for UBE2M Gene

Sources for UBE2M Gene

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