Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UBE2M Gene

protein-coding   GIFtS: 66
GCID: GC19M059067

Ubiquitin-Conjugating Enzyme E2M

(Previous names: ubiquitin-conjugating enzyme E2M (homologous to yeast UBC12),...)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin-Conjugating Enzyme E2M1 2     NEDD8-Conjugating Enzyme Ubc122
UBC122 3 5     Ubiquitin Carrier Protein M2
Ubiquitin-Conjugating Enzyme E2M (UBC12 Homolog, Yeast)1 2     Ubiquitin-Protein Ligase M2
NEDD8 Carrier Protein2 3     Yeast UBC12 Homolog2
NEDD8 Protein Ligase2 3     EC 6.3.2.-3
Ubiquitin-Conjugating Enzyme E2M (Homologous To Yeast UBC12)1     Ubiquitin-Conjugating Enzyme E2 M3
UBC-RS22     EC 6.3.28
hUbc122     

External Ids:    HGNC: 124911   Entrez Gene: 90402   Ensembl: ENSG000001307257   OMIM: 6031735   UniProtKB: P610813   

Export aliases for UBE2M gene to outside databases

Previous GC identifers: GC19M059965 GC19M059521 GC19M063742 GC19M063758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UBE2M Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with
a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. (provided by
RefSeq, Jul 2008)

GeneCards Summary for UBE2M Gene:
UBE2M (ubiquitin-conjugating enzyme E2M) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and ribosomal S6-glutamic acid ligase activity. An important paralog of this gene is UBE2F-SCLY.

UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent
attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests
that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in
cell proliferation

Gene Wiki entry for UBE2M Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2M gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2M promoter sequence
   Search Chromatin IP Primers for UBE2M

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

UBE2M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2M gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M059067:  view genomic region     (about GC identifiers)

Start:
59,067,079 bp from pter      End:
59,070,343 bp from pter
Size:
3,265 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081 (See protein sequence)
Recommended Name: NEDD8-conjugating enzyme Ubc12  
Size: 183 amino acids; 20900 Da
Subunit: Interacts with UBA3, DCUN1D1 and RBX1
6 PDB 3D structures from and Proteopedia for UBE2M:
1TT5 (3D)        1Y8X (3D)        2NVU (3D)        3TDU (3D)        3TDZ (3D)        4GAO (3D)    
Secondary accessions: O76069 Q8VC50

Explore the universe of human proteins at neXtProt for UBE2M: NX_P61081

Explore proteomics data for UBE2M at MOPED

Post-translational modifications: 

  • The acetylation of Met-1 increases affinity for DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8
    transfer to cullins1
  • Ubiquitination2 at Lys8, Lys36, Lys75, Lys81
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for UBE2M (P61081)
     ELNLPKTC  CLNILREDW  DDLLNFKLVICPDEGFYK  KKASAAQLRIQKDINELNLP 


    See UBE2M Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003960.1  
    ENSEMBL proteins: 
     ENSP00000253023   ENSP00000468940   ENSP00000469855  
    Reactome Protein details: P61081

    UBE2M Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant UBE2M Protein
    R&D Systems Recombinant & Natural Proteins for UBE2M (UBE2M/Ubc12)
    Enzo Life Sciences proteins for UBE2M
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UBE2M
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UBE2M
    GenScript Custom Purified and Recombinant Proteins Services for UBE2M
    Novus Biologicals UBE2M Proteins
    Novus Biologicals UBE2M Lysate
    Sino Biological Recombinant Protein for UBE2M
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBE2M
    Cloud-Clone Corp. Proteins for UBE2M

     
    Search eBioscience for Proteins for UBE2M 

    UBE2M Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UBE2M
    R&D Systems Antibodies for UBE2M (UBE2M/Ubc12)
    Cell Signaling Technology (CST) Antibodies for UBE2M 
    OriGene Antibodies for UBE2M
    OriGene Custom Antibody Services for UBE2M
    Novus Biologicals UBE2M Antibodies
    Search for Antibodies for UBE2M at Abcam
    Cloud-Clone Corp. Antibodies for UBE2M
    ThermoFisher Antibodies for UBE2M
    LSBio Antibodies in human, mouse, rat for UBE2M

    UBE2M Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBE2M
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBE2M
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBE2M
    Cloud-Clone Corp. CLIAs for UBE2M
    Search eBioscience for ELISAs for UBE2M 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry P61081

    ProtoNet protein and cluster: P61081

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081
    Domain: Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex
    simultaneously for optimal transfer of NEDD8
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily


    Find genes that share domains with UBE2M           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBC12_HUMAN, P61081
    Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent
    attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests
    that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in
    cell proliferation
    Catalytic activity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS9694792
    GO:0005515protein binding IPI15361859
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0018169ribosomal S6-glutamic acid ligase activity IDA15361859
         
    Find genes that share ontologies with UBE2M           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2M:
     Decreased G3BP1 protein expres  Increased cell death HMECs cel  Synthetic lethal with Ras 

         1 MGI phenotypic allele for Ube2m (no phenotypes)

    Find genes that share phenotypes with UBE2M           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2M
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2M

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2M
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2M

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2M:
    hsa-mir-93-5p (MIRT048746), hsa-let-7b-5p (MIRT032277)

    Block miRNA regulation of human, mouse, rat UBE2M using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2M (see all 16):
    hsa-miR-596 hsa-miR-579 hsa-miR-185* hsa-miR-1908 hsa-miR-650 hsa-miR-633 hsa-miR-3143 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidUBE2M 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBE2M
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2M

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBE2M

    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2M (see all 6)
    OriGene ORF clones in mouse, rat for UBE2M
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2M (NM_003969)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2M
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2M
    Addgene plasmids for UBE2M 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBE2M
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBE2M 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2M


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with UBE2M           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UBE2M About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    3TGF-beta receptor signaling activates SMADs
    TGF-beta receptor signaling activates SMADs0.82
    4Signaling by GPCR
    Signal Transduction0.58
    5Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis


    Find genes that share SuperPaths with UBE2M           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2M
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for UBE2M
        Protein Stability


    2 Reactome Pathways for UBE2M
        TGF-beta receptor signaling activates SMADs
    Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for UBE2M):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081
    Pathway: Protein modification; protein neddylation

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2M: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2M

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2M (P610811, 2, 3 ENSP000002530234) via UniProtKB, MINT, STRING, and/or I2D (see all 912)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136161, 2, 3, ENSP000003268044EBI-1041660,EBI-359390 MINT-6542674 MINT-7945693 MINT-6175286 MINT-7947479 I2D: score=2 STRING: ENSP00000326804
    PSMC4P436862, 3MINT-7945693 MINT-7947479 I2D: score=4 
    NAE1Q135642, 3, ENSP000002908104MINT-6542674 I2D: score=3 STRING: ENSP00000290810
    ACTR2P611602, 3MINT-7945693 MINT-7947479 I2D: score=1 
    MDN1Q9NU222, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS9694792
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0016567protein ubiquitination TAS9694792
    GO:0043525positive regulation of neuron apoptotic process IEA--
    GO:0045116protein neddylation IEA--

    Find genes that share ontologies with UBE2M           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2M (UBC12)

    4 HMDB Compounds for UBE2M    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UBE2M gene: 
    NM_003969.3  

    Unigene Cluster for UBE2M:

    Ubiquitin-conjugating enzyme E2M
    Hs.406068  [show with all ESTs]
    Unigene Representative Sequence: BM423509
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253023(uc002qtl.4) ENST00000595957 ENST00000596985 ENST00000599829
    ENST00000593801
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBE2M using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2M (see all 16):
    hsa-miR-596 hsa-miR-579 hsa-miR-185* hsa-miR-1908 hsa-miR-650 hsa-miR-633 hsa-miR-3143 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidUBE2M 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBE2M
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2M
    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2M (see all 6)
    OriGene ORF clones in mouse, rat for UBE2M
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2M (NM_003969)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2M
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2M
    Addgene plasmids for UBE2M 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBE2M
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2M
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2M
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2M
      QuantiFast Probe-based Assays in human, mouse, rat UBE2M

    Additional mRNA sequence: 

    AB012191.1 BC058924.1 BT006754.1 

    15 DOTS entries:

    DT.100797337  DT.118760  DT.100797334  DT.95094085  DT.100797341  DT.100797332  DT.121473486  DT.121473585 
    DT.95114897  DT.100797343  DT.95094086  DT.97854659  DT.100797331  DT.121473483  DT.97869739 

    Selected AceView cDNA sequences (see all 250):

    CR599501 BC058924 BP432687 BE257314 BM854547 AA512976 AA588183 F30078 
    CF128617 BM700562 CR597325 F30409 CR625272 CR614452 CR602537 BQ934496 
    CB267928 BU186068 BQ431502 BM468167 BM680955 BI522634 BU508830 AI141340 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2M    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                -                     
    SP2:                                -                     
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for UBE2M

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UBE2M expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTAAGGT
    UBE2M Expression
    About this image

    UBE2M Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2M Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.406068
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2M: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2M
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2M
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2M
    QuantiTect SYBR Green Assays in human, mouse, rat UBE2M
    QuantiFast Probe-based Assays in human, mouse, rat UBE2M
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2M

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2M gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2m1 , 5 ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)5
    ubiquitin-conjugating enzyme E2M1
    94.35(n)1
    100(a)1
      7 (7.73 cM)5
    221921  NM_145578.31  NP_663553.11 
     130352385 
    chicken
    (Gallus gallus)
    Aves UBE2M6
    ubiquitin-conjugating enzyme E2M
    47(a)
    1 ↔ 1
    AADN03013269.1(21-1027)
    lizard
    (Anolis carolinensis)
    Reptilia UBE2M6
    ubiquitin-conjugating enzyme E2M
    98(a)
    1 ↔ 1
    GL343253.1(119455-130809)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480591772   -- 81.46(n)    48059177 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb58e052 Transcribed sequence with moderate similarity to protein more 81.07(n)    CA469653.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73753
    Ubc121
    ubiquitin conjugating enzyme3
    Ubiquitin conjugating enzyme 121
    75(a)3
    73.56(n)1
    76.54(a)1
      66B123
    389161  NM_001274639.11  NP_001261568.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC12(YLR306W)4
    UBC121
    Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like more4
    UBC121
    50.93(n)1
    43.33(a)1
      12(744151-744851)4
    8510151, 4  NP_013409.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G186001 AT2G18600 59.89(n)
    63.19(a)
      816375  NM_127416.3  NP_565440.1 
    rice
    (Oryza sativa)
    Liliopsida Os.146562 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.79(n)    AK066484.1 


    ENSEMBL Gene Tree for UBE2M (if available)
    TreeFam Gene Tree for UBE2M (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UBE2M gene
    UBE2F-SCLY2  UBE2F2  
    Selected SIMAP similar genes for UBE2M using alignment to 3 protein entries:     UBC12_HUMAN (see all proteins) (see all similar genes):
    HR6A    UBE2D2    UBE2D3    UBE2A    UBE2D4    UBE2D1
    UBE2B    UBE2W    UBE2N    UBE2K    UBE2F    UBE2E3
    UBE2E2    UBE2I    UBE2L6    UBE2E1    UBE2S    UBE2C

    Find genes that share paralogs with UBE2M           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UBE2M
    PGOHUM00000248853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    2 SNPs for UBE2M    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018576881,2
    --59068519(+) CTCGTC/TTATGT 2 N D mis10--------
    rs2006673821,2
    --59068528(+) GTCTGG/TGTTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for UBE2M (59067079 - 59070343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UBE2M:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv4032n71CNV Loss21882294
    nsv912546CNV Loss21882294
    nsv828657CNV Gain20364138
    nsv515731CNV Gain+Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2M
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2M

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603173    OMIM disorders: --


    Find genes that share disorders with UBE2M           About GenesLikeMe


    Export disorders for UBE2M gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UBE2M gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with UBE2M)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new NEDD8-ligating system for cullin-4A. (PubMed id 9694792)1, 2, 3 Osaka F.... Kato S. (Genes Dev. 1998)
    2. A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. (PubMed id 10828074)1, 2, 9 Wada H.... Kamitani T. (J. Biol. Chem. 2000)
    3. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PubMed id 23201271)1, 2 Monda J.K....Schulman B.A. (Structure 2013)
    4. N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. (PubMed id 21940857)1, 2 Scott D.C.... Schulman B.A. (Science 2011)
    5. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2 Huang D.T....Schulman B.A. (Mol. Cell 2009)
    6. Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. (PubMed id 15694336)1, 2 Huang D.T....Schulman B.A. (Mol. Cell 2005)
    7. A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. (PubMed id 15361859)1, 2 Huang D.T.... Schulman B.A. (Nat. Struct. Mol. Biol. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. (PubMed id 10207026)1, 2 Gong L. and Yeh E.T.H. (J. Biol. Chem. 1999)
    10. The mechanism of poly-NEDD8 chain formation in vitro. (PubMed id 19245792)1, 9 Ohki Y....Chiba T. (Biochem. Biophys. Res. Commun. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9040 HGNC: 12491 AceView: UBE2M Ensembl:ENSG00000130725 euGenes: HUgn9040
    ECgene: UBE2M Kegg: 9040 H-InvDB: UBE2M

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UBE2M Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UBE2M gene:
    Search GeneIP for patents involving UBE2M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UBE2M
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant UBE2M Protein
     
     EMD Millipore genomic analysis products

      
     Antibodies for UBE2M (UBE2M/Ubc12)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for UBE2M (UBE2M/Ubc12)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBE2M   OriGene RNAi products in human, mouse, rat for UBE2M  
     OriGene qPCR primer pairs and template standards for UBE2M   OriGene Protein Over-expression Lysate for UBE2M  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UBE2M  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBE2M   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UBE2M   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBE2M   OriGene Custom Protein Services for UBE2M  

     
     
     Block miRNA regulation of human, mouse, rat UBE2M using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UBE2M
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2M Predesigned siRNA for gene silencing in human, mouse, rat UBE2M
     QuantiFast Probe-based Assays in human, mouse, rat UBE2M QuantiTect SYBR Green Assays in human, mouse, rat UBE2M
     PCR Arrays including human, mouse, rat UBE2M Search Chromatin IP Primers for UBE2M
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2M  GeneGlobe Interaction Network for UBE2M
     Regulatory tfbs in UBE2M promoter
     GenScript Custom Purified and Recombinant Proteins Services for UBE2M GenScript cDNA clones with any tag delivered in your preferred vector for UBE2M
     GenScript Custom Assay Services for UBE2M GenScript Custom overexpressing Cell Line Services for UBE2M
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for UBE2M 

     Search Tocris compounds for UBE2M (UBC12)
     Proteins for UBE2M
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for UBE2M
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UBE2M antibodies
     UBE2M proteins
     UBE2M lysates
     Search for Antibodies for UBE2M at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for UBE2M
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UBE2M
     Proteins for UBE2M
     Antibodies for UBE2M
     ELISAs for UBE2M
     CLIAs for UBE2M



     Browse ESI BIO Cell Lines and PureStem Progenitors for UBE2M
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2M
     SwitchGear 3'UTR luciferase reporter plasmids for UBE2M
     SwitchGear Promoter luciferase reporter plasmids for UBE2M
     ThermoFisher Antibodies for UBE2M
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2M
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2M
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2M
     LSBio Antibodies in human, mouse, rat for UBE2M
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for UBE2M
      Search eBioscience for proteins for UBE2M
      Search eBioscience for elisas for UBE2M
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBE2M gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4