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UBE2M Gene

protein-coding GIFtS: 63

GC19M063758

ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)
(Previous name: ubiquitin-conjugating enzyme E2M (homologous to yeast UBC12) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.3.2.- ^³
UBC-RS2 ^²
UBC12 ^¹, ², ³
hUbc12 ^¹, ²

Descriptions
NEDD8 carrier protein ^³
NEDD8 protein ligase ^³
Ubiquitin-conjugating enzyme E2 M ^³
nedd8-conjugating enzyme Ubc12 ^²
ubiquitin carrier protein M ^²
ubiquitin-conjugating enzyme E2M ^²
ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) ^²
ubiquitin-conjugating enzyme E2M (homologous to yeast UBC12) ^¹, ²
ubiquitin-protein ligase M ^²
yeast UBC12 homolog ^²

External Ids
HGNC: 12491¹
Entrez Gene: 9040²
UniProtKB: P61081³
Ensembl: ENSG00000130725⁷

Search outside databases for aliases for UBE2M gene

Previous GC identifers: GC19M059965 GC19M059521 GC19M063742

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2M:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. The encoded protein is linked with a ubiquitin-like protein, NEDD8, which can be

conjugated to cellular proteins, such as Cdc53/culin. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081

Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its

covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1,

but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as

CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation

Gene Wiki entry for UBE2M

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2M gene

Entrez Gene cytogenetic band: 19q13.43 Ensembl cytogenetic band: 19q13.43 HGNC cytogenetic band: 19q13.43

UBE2M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M063758: (about GC identifiers)

Start:	63,758,891 bp from pter
End:	63,762,155 bp from pter
Size:	3,265 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081 (See protein sequence)

Recommended Name: NEDD8-conjugating enzyme Ubc12

Size: 183 amino acids; 20900 Da

Subunit: Interacts with UBA3 and RBX1

PDB structures from and Proteopedia :

1TT5 (3D)

1Y8X (3D)

2NVU (3D)

Secondary accessions: O76069 Q8VC50

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_003960.1

ENSEMBL proteins:

ENSP00000253023

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBE2M Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2M
	Recombinant Proteins from Abcam (UBE2M)
	Human Recombinant Proteins from Abnova (UBE2M)

OriGene Purified Recombinant Human Protein: UBE2M

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

About this table

Antibodies for UBE2M:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE2M
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for UBE2M (ubc12)
	Antibodies from Abcam (UBE2M), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2M)
	Novus Biologicals Antibody for UBE2M

Assays for UBE2M:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61081

ProtoNet protein and cluster: P61081

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081

Domain: Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1

complex simultaneously for optimal transfer of NEDD8

Similarity: Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2M)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2M)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003969

Applied Biosystems Silencer® siRNAs for UBE2M

Sigma-Aldrich siRNA and siRNA Panels for UBE2M

Sigma-Aldrich shRNA Panels and shRNA for UBE2M

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003969
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003969
untagged cDNA clone in CMV expression vector: NM_003969

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003969

UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081

Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its

covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1,

but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as

CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation

Catalytic activity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine

Enzyme Number (IUBMB): EC 6.3.2.-

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	9694792
GO:0005515	protein binding	IPI	15361859
GO:0005524	ATP binding	IEA	--
GO:0016874	ligase activity	IEA	--
GO:0018169	ribosomal S6-glutamic acid ligase activity	IDA	15361859

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2M (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway
Hypoxia Signaling in the Cardiovascular System

GeneDecks UBE2M for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081

Pathway: Protein modification; protein neddylation

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2M

5/188 Interacting proteins for UBE2M (ENSP00000253023³ P61081^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 188 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBA3	Q8TBC4¹	STRING (score=.999) EBI-1041660, EBI-717567
CUL1	Q13616²	STRING (score=.969) MINT-6542674 MINT-6175286
CUL2	Q13617²	STRING (score=.717) MINT-6542674
CUL3	Q13618²	STRING (score=.718) MINT-6542674
CUL4A	Q13619²	STRING (score=.785) MINT-6542674

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019941	modification-dependent protein catabolic process	IEA	--
GO:0043687	post-translational protein modification	IEA	--
GO:0051246	regulation of protein metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2M

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2M)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2M)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003969

Sigma-Aldrich siRNA and siRNA Panels for UBE2M

Sigma-Aldrich shRNA Panels and shRNA for UBE2M

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003969

REFSEQ mRNAs for UBE2M gene:

NM_003969.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003969

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003969
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003969
                                 untagged cDNA clone in CMV expression vector: NM_003969

Additional cDNA sequence:

AB012191.1 BC058924.1 BT006754.1 CR592285.1 CR597325.1 CR599501.1 CR600769.1 CR602537.1

CR604136.1 CR611045.1 CR614452.1 CR617667.1 CR623679.1 CR625272.1

14 DOTS entries:

DT.100797337 DT.118760 DT.100797334 DT.95094085 DT.100797341 DT.100797332 DT.100797343 DT.121473486

DT.121473585 DT.95114897 DT.95094086 DT.97854659 DT.100797331 DT.121473483

24/250 AceView cDNA sequences (see all 250 ):

BM680955 BM798750 AW935177 AA512976 BI063316 CR611045 BU508830 BM790155

BM700562 BE257314 CR597325 BM453243 CR614452 BP432687 CR600769 AA588183

F30409 CR599501 BU186068 CR592285 BM854547 AA261836 BX357327 CR617667

highest scoring ESTs for UBE2M:

AA092705 AB012191 AL521469 AL530633 AL535436 AL555639 AL575624 AL578088 AW901677 AW901678

Unigene Cluster for UBE2M:

Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)

Hs.406068 [show with all ESTs]

Unigene Representative Sequence: BM423509

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2M

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7a	·	7b
SP1:											-
SP2:											-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for UBE2M

1 Ensembl transcript including schematic representation:

ENST00000253023

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2M expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2M

¹ / ² / ³

4 probe-sets matching UBE2M gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33782_r_at²^{, 3}	U95-A	2	1.00	0.91	0.93	1.13	AA587372	0.60	1.00	0.82	1
33781_s_at²^{, 3}	U95-A	2	1.00	0.81	0.95	0.87	AF075599	0.60	1.00	0.82	1
203109_at²^{, 3}	U133-A	2	1.00	0.73	--	--	NM_003969	0.60	1.00	0.82	1
203109_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--

GeneDecks UBE2M for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGATTAAGGT

SOURCE GeneReport for Unigene cluster: Hs.406068
Expression variation in blood from EXPOLDB for UBE2M

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2M gene from 5/24 species (see all 24 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2M¹	--	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	97.27(n) 100(a)	484221 XM_541337.2 XP_541337.2
chimpanzee (Pan troglodytes)	UBE2M¹	--	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	98.69(n) 98.04(a)	742993 XM_001146573.1 XP_001146573.1
cow (Bos taurus)	UBE2M¹	--	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	96.54(n) 100(a)	613343 XM_864007.2 XP_869100.2
rat (Rattus norvegicus)	Ube2m¹	--	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)	94.67(n) 100(a)	361509 XM_341790.3 XP_341791.2
mouse (Mus musculus)	Ube2m^{1, 5}	7 (4.00 cM)⁵	ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)^{1, 5}	94.35(n)¹ 100(a)¹	22192¹ NM_145578.1¹ NP_663553.1¹ BC021792⁵ BC026581⁵ (see all 7)

About this table Species with no ortholog for UBE2M

ENSEMBL Gene Tree for UBE2M

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2M gene

UBE2F²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

8 NCBI SNPs in UBE2M are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3794963^1,2	C,F,H	63762863(-)	`TGACCG/CGCAGA`	1	--	ng3¹		4		EA EU	1578
	rs3794964^1,2	C,F,H	63762728(-)	`ACTTGA/GGGCCC`	1	--	ng3¹		5		EA EU WA	1890
	rs3794965^1,2	C,F,H	63761165(-)	`AACTGG/ACGACT`	1	--	int¹		4		EA EU	1790
--	rs3794966^1,2	F	63760808(-)	`GTGGGG/AGTCAC`	1	--	int¹		1		EA	1492
--	rs12976233^1,2	--	63761822(+)	`ctgttC/Gtcggg`	1	--	ut5¹ ese³		0	--	--	--	--
--	rs7251957^1,2	--	63762819(+)	`CAATCA/TCAGCT`	1	--	ng3¹		0	--	--	--	--
--	rs35298407^1,2	--	63763038(+)	`TGTTA-/CCCTGC`	1	--	ng3¹		0	--	--	--	--
	rs28699075^1,2	--	63761026(+)	`GACTCA/TGAGAT`	1	--	int¹		0	--	--	--	--

About this table
The following additional 32 SNP(s) have been found in Applied Biosystems data source:

(Click for Applied Biosystems TaqMan ® Genotyping Assay)

rs10414380	rs895374	rs1044565	rs873104	rs2229255	rs28575910	rs4756
rs3764526	rs10413586	rs1058144	rs3177787	rs1058140	rs3816329	rs35771767
rs61738781	rs2305121	rs7249714	rs61738789	rs2396991	rs35271350	rs11669345
rs11546274	rs35126926	rs12104253	rs11881270	rs3810125	rs1109408	rs2305119
rs3816328	rs7249841	rs61738784	rs2305120

HapMap Linkage Disequilibrium images for UBE2M (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603173

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/24 PubMed articles for UBE2M gene (see all 24 ):

A new NEDD8-ligating system for cullin-4A. (PubMed id 9694792)^{2, 3, 4} Osaka F.... Kato S. (1998)
A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. (PubMed id 10828074)^{1, 3, 4} Wada H.... Kamitani T. (2000)
Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. (PubMed id 15694336)^{3, 4} Huang D.T....Schulman B.A. (2005)
A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. (PubMed id 15361859)^{3, 4} Huang D.T.... Schulman B.A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. (PubMed id 10207026)^{3, 4} Gong L. and Yeh E.T.H. (1999)
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)⁴ Huang D.T....Schulman B.A. (2009)
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation. (PubMed id 18826954)³ Kim A.Y....Singh B. (2008)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 9040	HGNC: 12491	AceView: UBE2M	Ensembl:ENSG00000130725	euGenes: HUgn9040
ECgene: UBE2M	H-InvDB: UBE2M

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for UBE2M
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBE2M:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2M-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2M		Antibodies for UBE2M
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE2M		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBE2M)
	Antibodies (UBE2M)
	Chimera RNAi (UBE2M)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for UBE2M (ubc12)

	Recombinant Proteins (UBE2M)
	Antibodies (UBE2M)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for UBE2M

	Proteins for UBE2M
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for UBE2M

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UBE2M Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for UBE2M

Summaries
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Genomic Location
for UBE2M

Proteins
for UBE2M

Protein Domains/
Families
for UBE2M

Gene Function
for UBE2M

Pathways & Interactions
for UBE2M

Drugs & Compounds
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Transcripts
for UBE2M

Expression
for UBE2M

Orthologs
for UBE2M

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Medical News
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Genome Databases showing UBE2M

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Licensable Technologies
for UBE2M

Services
for UBE2M

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2M Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor UBE2M

Summariesfor UBE2M

Genomic Locationfor UBE2M

Proteinsfor UBE2M

Protein Domains/Familiesfor UBE2M

Gene Functionfor UBE2M

Pathways & Interactionsfor UBE2M

Drugs & Compoundsfor UBE2M

Transcriptsfor UBE2M

Expression for UBE2M

Orthologsfor UBE2M

Paralogsfor UBE2M

SNPs/Variantsfor UBE2M

Disorders & Mutationsfor UBE2M

Medical Newsfor UBE2M

Publicationsfor UBE2M

Search for UBE2M

Genome Databases showing UBE2M

Other Databases showing UBE2M

Specialized Databases showing UBE2M

Licensable Technologiesfor UBE2M

Servicesfor UBE2M

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2M

Summaries
for UBE2M

Genomic Location
for UBE2M

Proteins
for UBE2M

Protein Domains/
Families
for UBE2M

Gene Function
for UBE2M

Pathways & Interactions
for UBE2M

Drugs & Compounds
for UBE2M

Transcripts
for UBE2M

Expression
for UBE2M

Orthologs
for UBE2M

Paralogs
for UBE2M

SNPs/Variants
for UBE2M

Disorders & Mutations
for UBE2M

Medical News
for UBE2M

Publications
for UBE2M

Licensable Technologies
for UBE2M

Services
for UBE2M