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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2M Gene

protein-coding   GIFtS: 66
GCID: GC19M059067

Ubiquitin-Conjugating Enzyme E2M

(Previous names: ubiquitin-conjugating enzyme E2M (homologous to yeast UBC12),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2M1 2     NEDD8-Conjugating Enzyme Ubc122
Ubiquitin-Conjugating Enzyme E2M (UBC12 Homolog, Yeast)1 2     Ubiquitin Carrier Protein M2
UBC122 3     Ubiquitin-Protein Ligase M2
NEDD8 Carrier Protein2 3     Yeast UBC12 Homolog2
NEDD8 Protein Ligase2 3     EC 6.3.2.-3
Ubiquitin-Conjugating Enzyme E2M (Homologous To Yeast UBC12)1     Ubiquitin-Conjugating Enzyme E2 M3
UBC-RS22     EC 6.3.28
hUbc122     

External Ids:    HGNC: 124911   Entrez Gene: 90402   Ensembl: ENSG000001307257   OMIM: 6031735   UniProtKB: P610813   

Export aliases for UBE2M gene to outside databases

Previous GC identifers: GC19M059965 GC19M059521 GC19M063742 GC19M063758


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2M Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is linked with
a ubiquitin-like protein, NEDD8, which can be conjugated to cellular proteins, such as Cdc53/culin. (provided by
RefSeq, Jul 2008)

GeneCards Summary for UBE2M Gene: 
UBE2M (ubiquitin-conjugating enzyme E2M) is a protein-coding gene. Diseases associated with UBE2M include gastric cancer, and neuronitis, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and ribosomal S6-glutamic acid ligase activity. An important paralog of this gene is UBE2F-SCLY.

UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent
attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests
that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in
cell proliferation

Gene Wiki entry for UBE2M Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2M gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2M promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2M

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2M


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.43   Ensembl cytogenetic band:  19q13.43   HGNC cytogenetic band: 19q13.43

UBE2M Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2M gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M059067:  view genomic region     (about GC identifiers)

Start:
59,067,079 bp from pter      End:
59,070,343 bp from pter
Size:
3,265 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081 (See protein sequence)
Recommended Name: NEDD8-conjugating enzyme Ubc12  
Size: 183 amino acids; 20900 Da
Subunit: Interacts with UBA3, DCUN1D1 and RBX1
6 PDB 3D structures from and Proteopedia for UBE2M:
1TT5 (3D)        1Y8X (3D)        2NVU (3D)        3TDU (3D)        3TDZ (3D)        4GAO (3D)    
Secondary accessions: O76069 Q8VC50

Explore the universe of human proteins at neXtProt for UBE2M: NX_P61081

Explore proteomics data for UBE2M at MOPED 

Post-translational modifications:

  • UniProtKB: The acetylation of Met-1 is cotranslational, and not regulatory. The N-acetylmethionine increases affinity for
    DCUN1D1 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61081

  • 4 DME Specific Peptides for UBE2M (P61081)
     ELNLPKTC  CLNILREDW  DDLLNFKLVICPDEGFYK  KKASAAQLRIQKDINELNLP 

    UBE2M Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2M Protein Expression
    REFSEQ proteins: NP_003960.1  
    ENSEMBL proteins: 
     ENSP00000253023   ENSP00000468940   ENSP00000469855  
    Reactome Protein details: P61081
    Human Recombinant Protein Products for UBE2M: 
    EMD Millipore Purified and/or Recombinant UBE2M Protein
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    Enzo Life Sciences proteins for UBE2M
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    Novus Biologicals UBE2M Proteins
    Novus Biologicals UBE2M Lysate
    Sino Biological Recombinant Protein for UBE2M
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    ProSpec Recombinant Protein for UBE2M
    Cloud-Clone Corp. Proteins for UBE2M 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--

    UBE2M for ontologies           About GeneDecksing



    UBE2M Antibody Products: 
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    Abcam antibodies for UBE2M
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    Assay Products for UBE2M: 
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    Cloud-Clone Corp. CLIAs for UBE2M


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P61081

    ProtoNet protein and cluster: P61081

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081
    Domain: Both the N-terminal docking peptide and the catalytic core domain must bind the UBA3-NAE1 complex
    simultaneously for optimal transfer of NEDD8
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily


    UBE2M for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBC12_HUMAN, P61081
    Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent
    attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests
    that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in
    cell proliferation
    Catalytic activity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS9694792
    GO:0005515protein binding IPI15361859
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0018169ribosomal S6-glutamic acid ligase activity IDA15361859
         
    UBE2M for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2M:
     Decreased G3BP1 protein expres  Increased cell death HMECs cel  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2M 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2M

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2M 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2M 

    miRNA
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    8/16 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2M (see all 16):
    hsa-miR-596 hsa-miR-579 hsa-miR-185* hsa-miR-1908 hsa-miR-650 hsa-miR-633 hsa-miR-3143 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidUBE2M 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2M About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    4Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions
    5Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2M
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for UBE2M
        Protein Stability


    4        Reactome Pathways for UBE2M
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE2M):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBC12_HUMAN, P61081
    Pathway: Protein modification; protein neddylation


    UBE2M for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2M

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/897 Interacting proteins for UBE2M (P610811, 2, 3 ENSP000002530234) via UniProtKB, MINT, STRING, and/or I2D (see all 897)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    CUL1Q136162, 3, ENSP000003268044MINT-6542674 MINT-7945693 MINT-6175286 MINT-7947479 I2D: score=2 STRING: ENSP00000326804
    PSMC4P436862, 3MINT-7945693 MINT-7947479 I2D: score=4 
    NAE1Q135642, 3, ENSP000002908104MINT-6542674 I2D: score=3 STRING: ENSP00000290810
    ACTR2P611602, 3MINT-7945693 MINT-7947479 I2D: score=1 
    MDN1Q9NU222, 3MINT-7945693 MINT-7947479 I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS9694792
    GO:0016567protein ubiquitination TAS9694792
    GO:0043525positive regulation of neuron apoptotic process IEA--
    GO:0045116protein neddylation IEA--

    UBE2M for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2M (UBC12)

    4 HMDB Compounds for UBE2M    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2M / UBC12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2M gene: 
    NM_003969.3  

    Unigene Cluster for UBE2M:

    Ubiquitin-conjugating enzyme E2M
    Hs.406068  [show with all ESTs]
    Unigene Representative Sequence: BM423509
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000253023(uc002qtl.4) ENST00000595957 ENST00000596985 ENST00000599829
    ENST00000593801
    miRNA
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    hsa-miR-596 hsa-miR-579 hsa-miR-185* hsa-miR-1908 hsa-miR-650 hsa-miR-633 hsa-miR-3143 hsa-miR-34b
    SwitchGear 3'UTR luciferase reporter plasmidUBE2M 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB012191.1 BC058924.1 BT006754.1 

    15 DOTS entries:

    DT.100797337  DT.118760  DT.100797334  DT.95094085  DT.100797341  DT.100797332  DT.121473486  DT.121473585 
    DT.95114897  DT.100797343  DT.95094086  DT.97854659  DT.100797331  DT.121473483  DT.97869739 

    24/250 AceView cDNA sequences (see all 250):

    BI522634 CR604136 BT006754 F30078 BP432687 BC058924 CR611045 CR602537 
    CR592285 CR614452 AI141340 BM798750 BX357327 BM833180 CR597325 BM790155 
    BM710465 CR599501 CF128617 BQ934496 AA512976 BM854547 NM_003969 CR617667 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2M    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
    SP1:                                -                     
    SP2:                                -                     
    SP3:                                                      
    SP4:                                                      


    ECgene alternative splicing isoforms for UBE2M

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2M expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTAAGGT
    UBE2M Expression
    About this image


    See UBE2M Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2M

    SOURCE GeneReport for Unigene cluster: Hs.406068
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2M: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2M

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2M gene from 9/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2m1 , 5 ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast)5
    ubiquitin-conjugating enzyme E2M1
    94.35(n)1
    100(a)1
      7 (7.73 cM)5
    221921  NM_145578.31  NP_663553.11 
     130352385 
    chicken
    (Gallus gallus)
    Aves LOC1008586411 NEDD8-conjugating enzyme Ubc12-like 83.76(n)
    91.03(a)
      100858641  XM_003643841.1  XP_003643889.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2M6
    Uncharacterized protein
    98(a)
    1 ↔ 1
    GL343253.1(119455-130809)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480591772   -- 81.46(n)    48059177 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb58e052 Transcribed sequence with moderate similarity to protein more 81.07(n)    CA469653.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG73751 , 3 ubiquitin conjugating enzyme3
    CG73751
    75(a)3
    73.56(n)1
    76.54(a)1
      66B123
    389161  NM_139930.11  NP_648187.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC12(YLR306W)4 Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like more   --   12(744151-744851) 851015  NP_013409.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G186001 ubiquitin-conjugating enzyme E2 M 59.89(n)
    63.19(a)
      816375  NM_127416.3  NP_565440.1 
    rice
    (Oryza sativa)
    Liliopsida Os.146562 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 70.79(n)    AK066484.1 


    ENSEMBL Gene Tree for UBE2M (if available)
    TreeFam Gene Tree for UBE2M (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2M gene
    UBE2F-SCLY2  UBE2F2  
    18/20 SIMAP similar genes for UBE2M using alignment to 3 protein entries:     UBC12_HUMAN (see all proteins) (see all similar genes):
    HR6A    UBE2A    UBE2D2    UBE2D3    UBE2D4    UBE2D1
    UBE2B    UBE2W    UBE2N    UBE2K    UBE2F    UBE2E3
    UBE2E2    UBE2I    UBE2L6    UBE2E1    UBE2S    UBE2C

    UBE2M for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBE2M
    PGOHUM00000248853


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    2 SNPs in UBE2M are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018576881,2
    --59068519(+) CTCGTC/TTATGT 2 N D mis10--------
    rs2006673821,2
    --59068528(+) GTCTGG/TGTTTG 1 -- int10--------

    HapMap Linkage Disequilibrium report for UBE2M (59067079 - 59070343 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UBE2M:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv4032n71CNV Loss21882294
    nsv912546CNV Loss21882294
    nsv828657CNV Gain20364138
    nsv515731CNV Gain+Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603173    OMIM disorders: --

    2 diseases for UBE2M:    About MalaCards
    gastric cancer    neuronitis


    UBE2M for disorders           About GeneDecksing


    Export disorders for UBE2M gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2M gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with UBE2M)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A new NEDD8-ligating system for cullin-4A. (PubMed id 9694792)1, 2, 3 Osaka F.... Kato S. (1998)
    2. A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo. (PubMed id 10828074)1, 2, 9 Wada H.... Kamitani T. (2000)
    3. N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex. (PubMed id 21940857)1, 2 Scott D.C.... Schulman B.A. (2011)
    4. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2 Huang D.T....Schulman B.A. (2009)
    5. Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1. (PubMed id 15694336)1, 2 Huang D.T....Schulman B.A. (2005)
    6. A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8. (PubMed id 15361859)1, 2 Huang D.T.... Schulman B.A. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway. (PubMed id 10207026)1, 2 Gong L. and Yeh E.T.H. (1999)
    9. The mechanism of poly-NEDD8 chain formation in vitro. (PubMed id 19245792)1, 9 Ohki Y....Chiba T. (2009)
    10. Structural conservation of distinctive N-terminal acet ylation-dependent interactions across a family of mammalian NEDD8 ligation enzym es. (PubMed id 23201271)1 Monda J.K....Schulman B.A. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9040 HGNC: 12491 AceView: UBE2M Ensembl:ENSG00000130725 euGenes: HUgn9040
    ECgene: UBE2M Kegg: 9040 H-InvDB: UBE2M

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2M Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2M gene:
    Search GeneIP for patents involving UBE2M

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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