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Aliases for UBE2L6 Gene

Aliases for UBE2L6 Gene

  • Ubiquitin-Conjugating Enzyme E2L 6 2 3
  • UBCH8 3 4 6
  • Retinoic Acid-Induced Gene B Protein 3 4
  • Ubiquitin Carrier Protein L6 3 4
  • Ubiquitin-Protein Ligase L6 3 4
  • EC 6.3.2.19 4 63
  • RIG-B 3 4
  • Ubiquitin/ISG15-Conjugating Enzyme E2 L6 3
  • Retinoic Acid Induced Gene B Protein 3

External Ids for UBE2L6 Gene

Previous GeneCards Identifiers for UBE2L6 Gene

  • GC11M059713
  • GC11M058832
  • GC11M057094
  • GC11M057075
  • GC11M057319
  • GC11M053667

Summaries for UBE2L6 Gene

Entrez Gene Summary for UBE2L6 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for UBE2L6 Gene

UBE2L6 (Ubiquitin-Conjugating Enzyme E2L 6) is a Protein Coding gene. Diseases associated with UBE2L6 include diverticulitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Interferon Signaling. GO annotations related to this gene include ubiquitin-protein transferase activity and ISG15 transferase activity. An important paralog of this gene is UBE2L3.

UniProtKB/Swiss-Prot for UBE2L6 Gene

  • Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Gene Wiki entry for UBE2L6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2L6 Gene

Genomics for UBE2L6 Gene

Regulatory Elements for UBE2L6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2L6 Gene

Start:
57,551,655 bp from pter
End:
57,568,330 bp from pter
Size:
16,676 bases
Orientation:
Minus strand

Genomic View for UBE2L6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2L6 Gene

Proteins for UBE2L6 Gene

  • Protein details for UBE2L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14933-UB2L6_HUMAN
    Recommended name:
    Ubiquitin/ISG15-conjugating enzyme E2 L6
    Protein Accession:
    O14933
    Secondary Accessions:
    • A6NDM6
    • A8MY53
    • Q8N5D8
    • Q9UEZ0

    Protein attributes for UBE2L6 Gene

    Size:
    153 amino acids
    Molecular mass:
    17769 Da
    Quaternary structure:
    • Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated).
    SequenceCaution:
    • Sequence=CAB64566.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2L6 Gene

    Alternative splice isoforms for UBE2L6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2L6 Gene

Proteomics data for UBE2L6 Gene at MOPED

Selected DME Specific Peptides for UBE2L6 Gene

Post-translational modifications for UBE2L6 Gene

Other Protein References for UBE2L6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for UBE2L6 Gene

Gene Families for UBE2L6 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2L6 Gene

Suggested Antigen Peptide Sequences for UBE2L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14933

UniProtKB/Swiss-Prot:

UB2L6_HUMAN :
  • O14933
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2L6: view

Function for UBE2L6 Gene

Molecular function for UBE2L6 Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme H8,identified in a two hybrid screen through specific interaction with E6AP (E3) ubiquitin protein ligase in the E6-dependent ubiquination of TP53
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
UniProtKB/Swiss-Prot Induction: By IFNB1/IFN-beta.

Enzyme Numbers (IUBMB) for UBE2L6 Gene

Gene Ontology (GO) - Molecular Function for UBE2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 9153201
GO:0005515 protein binding IPI 10085091
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity --
genes like me logo Genes that share ontologies with UBE2L6: view

Phenotypes for UBE2L6 Gene

GenomeRNAi human phenotypes for UBE2L6:
genes like me logo Genes that share phenotypes with UBE2L6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2L6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UBE2L6 Gene

Localization for UBE2L6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2L6 Gene COMPARTMENTS Subcellular localization image for UBE2L6 gene
Compartment Confidence
cytosol 4
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UBE2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2L6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2L6 Gene

Pathways for UBE2L6 Gene

genes like me logo Genes that share pathways with UBE2L6: view

UniProtKB/Swiss-Prot O14933-UB2L6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006464 cellular protein modification process TAS 9153201
GO:0008152 metabolic process --
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with UBE2L6: view

Compounds for UBE2L6 Gene

(4) HMDB Compounds for UBE2L6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2L6: view

Transcripts for UBE2L6 Gene

Unigene Clusters for UBE2L6 Gene

Ubiquitin-conjugating enzyme E2L 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2L6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2L6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for UBE2L6 Gene

GeneLoc Exon Structure for
UBE2L6
ECgene alternative splicing isoforms for
UBE2L6

Expression for UBE2L6 Gene

mRNA expression in normal human tissues for UBE2L6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2L6 Gene

SOURCE GeneReport for Unigene cluster for UBE2L6 Gene Hs.425777

mRNA Expression by UniProt/SwissProt for UBE2L6 Gene

O14933-UB2L6_HUMAN
Tissue specificity: Present in natural killer cells (at protein level).
genes like me logo Genes that share expressions with UBE2L6: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE2L6 Gene

Orthologs for UBE2L6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2L6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2L6 35
  • 99.35 (n)
  • 100 (a)
UBE2L6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2L6 35
  • 78.65 (n)
  • 69.93 (a)
UBE2L6 36
  • 70 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2L6 35
  • 79.96 (n)
  • 70.59 (a)
UBE2L6 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2l6 35
  • 79.96 (n)
  • 76.47 (a)
Ube2l6 16
Ube2l6 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2L6 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2l6 35
  • 78.87 (n)
  • 73.86 (a)
chicken
(Gallus gallus)
Aves UBE2L6 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2L6 36
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta UbcD10 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-18 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 36
  • 36 (a)
ManyToMany
UBC5 36
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11086 36
  • 51 (a)
OneToMany
Species with no ortholog for UBE2L6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBE2L6 Gene

ENSEMBL:
Gene Tree for UBE2L6 (if available)
TreeFam:
Gene Tree for UBE2L6 (if available)

Paralogs for UBE2L6 Gene

Paralogs for UBE2L6 Gene

Selected SIMAP similar genes for UBE2L6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBE2L6: view

Variants for UBE2L6 Gene

Sequence variations from dbSNP and Humsavar for UBE2L6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs5847 -- 57,551,866(+) ATAAA(C/T)GGTTT utr-variant-3-prime
rs14889 -- 57,551,865(+) AATAA(A/T)TGGTT utr-variant-3-prime
rs475215 -- 57,556,715(+) AGGCC(A/C)ACAGC intron-variant
rs568190 -- 57,560,638(+) ttttt(G/T)gagac intron-variant
rs1058468 -- 57,567,896(-) GGATC(A/C)GCAAA upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2L6 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV Gain 17160897

Relevant External Links for UBE2L6 Gene

HapMap Linkage Disequilibrium report
UBE2L6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2L6 Gene

Disorders for UBE2L6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UBE2L6 Gene including...

Search for UBE2L6 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UBE2L6 Gene

genes like me logo Genes that share disorders with UBE2L6: view

No data available for UniProtKB/Swiss-Prot for UBE2L6 Gene

Publications for UBE2L6 Gene

  1. Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. (PMID: 9153201) Kumar S. … Howley P.M. (J. Biol. Chem. 1997) 2 3 4 23
  2. Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12. (PMID: 10894956) Ardley H.C. … Robinson P.A. (Cytogenet. Cell Genet. 2000) 3 4 23
  3. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PMID: 11237715) Niwa J. … Sobue G. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  4. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PMID: 16427630) Huang J. … Shu H.-B. (FEBS Lett. 2006) 3 4 23
  5. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PMID: 16709802) Fortier J.M. … Kornbluth J. (J. Immunol. 2006) 3 4 23

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