Aliases for UBE2L6 Gene
External Ids for UBE2L6 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
GeneCards Summary for UBE2L6 Gene
UBE2L6 (Ubiquitin-Conjugating Enzyme E2L 6) is a Protein Coding gene. Diseases associated with UBE2L6 include diverticulitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Interferon Signaling. GO annotations related to this gene include ubiquitin-protein transferase activity and ISG15 transferase activity. An important paralog of this gene is UBE2L3.
UniProtKB/Swiss-Prot for UBE2L6 Gene
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.