Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2L6 Gene

protein-coding   GIFtS: 68
GCID: GC11M057319

Ubiquitin-Conjugating Enzyme E2L 6

Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2L 61 2     RIG-B2 3
UBCH82 3 5     EC 6.3.2.193 8
Retinoic Acid-Induced Gene B Protein2 3     Retinoic Acid Induced Gene B Protein2
Ubiquitin Carrier Protein L62 3     Ubiquitin/ISG15-Conjugating Enzyme E2 L62
Ubiquitin-Protein Ligase L62 3     UbcH83

External Ids:    HGNC: 124901   Entrez Gene: 92462   Ensembl: ENSG000001565877   OMIM: 6038905   UniProtKB: O149333   

Export aliases for UBE2L6 gene to outside databases

Previous GC identifers: GC11M059713 GC11M058832 GC11M057571 GC11M057094 GC11M057075 GC11M053667


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2L6 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This
gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary
structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding
distinct isoforms have been found for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for UBE2L6 Gene: 
UBE2L6 (ubiquitin-conjugating enzyme E2L 6) is a protein-coding gene. Diseases associated with UBE2L6 include diverticulitis, and cblc, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and ISG15 ligase activity. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933
Function: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the
E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of
FLT3

Gene Wiki entry for UBE2L6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2L6 gene promoter:
         AREB6   STAT1   CUTL1   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2L6 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2L6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2L6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

UBE2L6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2L6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057319:  view genomic region     (about GC identifiers)

Start:
57,319,128 bp from pter      End:
57,335,803 bp from pter
Size:
16,676 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933 (See protein sequence)
Recommended Name: Ubiquitin/ISG15-conjugating enzyme E2 L6  
Size: 153 amino acids; 17769 Da
Subunit: Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated)
Sequence caution: Sequence=CAB64566.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for UBE2L6:
1WZV (3D)        1WZW (3D)        2KJH (3D)    
Secondary accessions: A6NDM6 A8MY53 Q8N5D8 Q9UEZ0
Alternative splicing: 2 isoforms:  O14933-1   O14933-2   

Explore the universe of human proteins at neXtProt for UBE2L6: NX_O14933

Explore proteomics data for UBE2L6 at MOPED 

Post-translational modifications:

  • UniProtKB: ISGylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14933

  • 2 DME Specific Peptides for UBE2L6 (O14933)
     KNAEEFT  TKIYHPN 

    UBE2L6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2L6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_004214.1  NP_937826.1  

    ENSEMBL proteins: 
     ENSP00000341980   ENSP00000287156   ENSP00000435265   ENSP00000434348  
    Reactome Protein details: O14933
    Human Recombinant Protein Products for UBE2L6: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UBE2L6 (UbcH8)
    Enzo Life Sciences proteins for UBE2L6
    OriGene Purified Proteins for UBE2L6
    OriGene Protein Over-expression Lysate for UBE2L6
    OriGene MassSpec for UBE2L6 
    OriGene Custom Protein Services for UBE2L6
    GenScript Custom Purified and Recombinant Proteins Services for UBE2L6
    Novus Biologicals UBE2L6 Proteins
    Novus Biologicals UBE2L6 Lysates
    Sino Biological Recombinant Protein for UBE2L6
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UBE2L6
    Cloud-Clone Corp. Proteins for UBE2L6 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    UBE2L6 for ontologies           About GeneDecksing



    UBE2L6 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UBE2L6
    OriGene Custom Antibody Services for UBE2L6
    GenScript Custom Superior Antibodies Services for UBE2L6
    Novus Biologicals UBE2L6 Antibodies
    Abcam antibodies for UBE2L6
    Cloud-Clone Corp. Antibodies for UBE2L6 
    ThermoFisher Antibodies for UBE2L6
    LSBio Antibodies in human, mouse, rat for UBE2L6 

    Assay Products for UBE2L6: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBE2L6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBE2L6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBE2L6 
    Cloud-Clone Corp. CLIAs for UBE2L6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry O14933

    ProtoNet protein and cluster: O14933

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2L6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2L6_HUMAN, O14933
    Function: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the
    E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of
    FLT3
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Induction: By IFNB1/IFN-beta

         Genatlas biochemistry entry for UBE2L6:
    ubiquitin conjugating enzyme H8,identified in a two hybrid screen through specific interaction with E6AP (E3)
    ubiquitin protein ligase in the E6-dependent ubiquination of TP53

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI10085091
    GO:0016881acid-amino acid ligase activity ----
    GO:0019787small conjugating protein ligase activity ----
    GO:0042296ISG15 ligase activity IEA--
         
    UBE2L6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2L6:
     Synthetic lethal with c-Myc af 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2L6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2L6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2L6 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2L6 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2L6
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2L6:
    hsa-miR-647 hsa-miR-4283 hsa-miR-125a-3p hsa-miR-331-3p
    SwitchGear 3'UTR luciferase reporter plasmidUBE2L6 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2L6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2L6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBE2L6
    Sirion Biotech Customized adenovirus for overexpression of UBE2L6

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UBE2L6 (see all 13)
    OriGene ORF clones in mouse, rat for UBE2L6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBE2L6 (NM_004223)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2L6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2L6
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2L6 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2L6 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBE2L6
    Search LifeMap BioReagents cell lines for UBE2L6
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2L6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2L6 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Immune System
    Immune System0.90
    Negative regulators of RIG-I/MDA5 signaling0.78
    Innate Immune System0.90
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.78
    4Interferon Signaling
    Interferon Signaling0.61
    Antiviral mechanism by IFN-stimulated genes0.42
    Cytokine Signaling in Immune system0.61
    ISG15 antiviral mechanism0.42
    5Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for UBE2L6
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2L6
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    2 GeneGo (Thomson Reuters) Pathways for UBE2L6
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    2 BioSystems Pathways for UBE2L6
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway


    5/15        Reactome Pathways for UBE2L6 (see all 15)
        Negative regulators of RIG-I/MDA5 signaling
    Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Immune System


    2         Kegg Pathways  (Kegg details for UBE2L6):
        Ubiquitin mediated proteolysis
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933
    Pathway: Protein modification; protein ubiquitination


    UBE2L6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2L6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/73 Interacting proteins for UBE2L6 (O149331, 2, 3 ENSP000002871564) via UniProtKB, MINT, STRING, and/or I2D (see all 73)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGDIAP525652, 3, ENSP000002693214MINT-8276233 I2D: score=2 STRING: ENSP00000269321
    RNF19BQ6ZMZ01, 3, ENSP000003625554EBI-2129974,EBI-2466594 I2D: score=2 STRING: ENSP00000362555
    ENSG00000237071P143733, ENSP000004052294I2D: score=2 STRING: ENSP00000405229
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS9153201
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019941modification-dependent protein catabolic process IEA--
    GO:0032020ISG15-protein conjugation IEA--
    GO:0032480negative regulation of type I interferon production TAS--

    UBE2L6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2L6 (UB2L6)

    4 HMDB Compounds for UBE2L6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2L6 / UB2L6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2L6 gene (2 alternative transcripts): 
    NM_004223.4  NM_198183.2  

    Unigene Cluster for UBE2L6:

    Ubiquitin-conjugating enzyme E2L 6
    Hs.425777  [show with all ESTs]
    Unigene Representative Sequence: NM_198183
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340573(uc001nko.2) ENST00000287156(uc001nkn.2) ENST00000528275
    ENST00000527022 ENST00000526659

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2L6
    4 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2L6:
    hsa-miR-647 hsa-miR-4283 hsa-miR-125a-3p hsa-miR-331-3p
    SwitchGear 3'UTR luciferase reporter plasmidUBE2L6 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2L6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2L6
    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2L6 (see all 13)
    OriGene ORF clones in mouse, rat for UBE2L6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBE2L6 (NM_004223)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2L6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2L6
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2L6 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2L6 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBE2L6
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2L6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2L6
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2L6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2L6

    Additional mRNA sequence: 

    AF031141.1 AF061736.1 AK093462.1 AK129621.1 AK226165.1 AK315755.1 BC032491.1 CR457126.1 

    11 DOTS entries:

    DT.447411  DT.100006077  DT.92410683  DT.101981816  DT.91754122  DT.95301343  DT.95301290  DT.91754123 
    DT.91754124  DT.95301342  DT.91824239 

    24/394 AceView cDNA sequences (see all 394):

    BM920035 AI445428 AI222251 AK129621 AW956195 BC032491 BM996993 AI669283 
    AI858014 BU655909 BE394965 NM_004223 BE612485 BU625117 BE740921 BI546592 
    BE743969 BM694229 AF031141 AK093462 BQ051009 AW051910 CB122118 BQ218026 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2L6    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:        -     -     -     -                                             
    SP2:              -     -     -                                             
    SP3:                    -     -                                             
    SP4:                          -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for UBE2L6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2L6 expression in normal human tissues (normalized intensities)      UBE2L6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTGCTTA
    UBE2L6 Expression
    About this image


    UBE2L6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Inner Cell Mass (Early Embryonic Tissues)
             CyT49
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)

    See UBE2L6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2L6

    SOURCE GeneReport for Unigene cluster: Hs.425777

    UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933
    Tissue specificity: Present in natural killer cells (at protein level)

        SABiosciences Custom PCR Arrays for UBE2L6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2L6
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2L6
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2L6
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2L6
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2L6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2L6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBE2L6 gene from 5/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2l61 , 5 ubiquitin-conjugating enzyme E2L 61, 5 79.96(n)1
    76.47(a)1
      2 (49.45 cM)5
    567911  NM_019949.21  NP_064333.21 
     847988285 
    chicken
    (Gallus gallus)
    Aves UBE2L66
    ubiquitin-conjugating enzyme E2L 6
    38(a)
    1 ↔ 1
    5(16306938-16308177)
    lizard
    (Anolis carolinensis)
    Reptilia UBE2L66
    ubiquitin-conjugating enzyme E2L 6
    52(a)
    1 ↔ 1
    1(91716499-91720951)
    fruit fly
    (Drosophila melanogaster)
    Insecta UbcD106
    Ubc84D6
    (see all 3)
    Ubiquitin conjugating enzyme 84D
    (see all 3)
    51(a)
    50(a)
    (see all 3)
    possible ortholog
    1 ↔ many
    (see all 3)
    2R(13675912-13676914)
    3R(3344542-3345178)
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-186
    Protein UBC-18
    47(a)
    1 → many
    III(7067687-7068572)


    ENSEMBL Gene Tree for UBE2L6 (if available)
    TreeFam Gene Tree for UBE2L6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2L6 gene
    UBE2D32  UBE2E32  UBE2D12  UBE2D42  UBE2E12  UBE2D22  UBE2E22  UBE2L32  
    18/19 SIMAP similar genes for UBE2L6 using alignment to 3 protein entries:     UB2L6_HUMAN (see all proteins) (see all similar genes):
    UBE2L3    HR6A    UBE2H    UBE2N    UBE2A    UBE2U
    UBE2D3    UBE2D2    UBE2D4    UBE2M    UBE2B    UBE2D1
    UBE2T    UBE2NL    UBE2G2    UBE2I    UBE2K    UBE2E3

    UBE2L6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/398 SNPs in UBE2L6 are shown (see all 398)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903370851,2
    --57318786(+) CTCAAA/GAGACT 2 -- ds50010--------
    rs1818167161,2
    --57318870(+) TGGGCA/GACGGA 2 -- ds50010--------
    rs122913371,2
    C,F--57318873(+) gcgacG/Agagtg 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs603377641,2
    C--57318889(+) CTGTCA/TTAAAT 2 -- ds50010--------
    rs2019025911,2
    --57318889(+) CTGTC-/TTAAA 
     TAAATAA
    ATAAA
    2 -- ds50010--------
    rs1126702951,2
    C--57318890(+) TGTCT-/TAAAT 
     AAATAAA
    TAAAT
    2 -- ds50011Minor allele frequency- TAAATAAATAAA:0.50CSA 2
    rs3753508731,2
    C--57318890(+) CTGTC-/TAA   
       ATAAA
    AAATA
    2 -- ds50010--------
    rs1139647861,2
    C,F--57318926(+) ATAAAT/AAAAAT 2 -- ds50012Minor allele frequency- A:0.04WA 120
    rs27293701,2
    C,F,A,H--57318943(+) GGGACG/ATCACC 2 -- ds500121Minor allele frequency- A:0.49NS EA NA WA CSA 2345
    rs1408221221,2
    C--57319144(+) TCTCTA/GACTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2L6 (57319128 - 57335803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2L6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832163CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2L6
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2L6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603890    OMIM disorders: --

    5 diseases for UBE2L6:    About MalaCards
    diverticulitis    cblc    parkinson's disease    leukemia
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for UBE2L6:
    Diverticulitis

    UBE2L6 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for UBE2L6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2L6 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with UBE2L6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. (PubMed id 9153201)1, 2, 3, 9 Kumar S.... Howley P.M. (1997)
    2. The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site. (PubMed id 19928833)1, 2, 9 Serniwka S.A. and Shaw G.S. (2009)
    3. Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12. (PubMed id 10894956)1, 2, 9 Ardley H.C....Robinson P.A. (2000)
    4. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1, 2, 9 Fortier J.M. and Kornbluth J. (2006)
    5. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PubMed id 16427630)1, 2, 9 Huang J.... Shu H.-B. (2006)
    6. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PubMed id 11237715)1, 2, 9 Niwa J.... Sobue G. (2001)
    7. Ubiquitin conjugase UBCH8 targets active FMS-like tyr osine kinase 3 for proteasomal degradation. (PubMed id 20508617)1, 2 Buchwald M....KrAomer O.H. (2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. (PubMed id 15131269)1, 2 Zhao C.... Krug R.M. (2004)
    10. The basis for selective E1-E2 interactions in the ISG15 conjugation system. (PubMed id 18583345)1, 9 Durfee L.A....Huibregtse J.M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9246 HGNC: 12490 AceView: UBE2L6 Ensembl:ENSG00000156587 euGenes: HUgn9246
    ECgene: UBE2L6 Kegg: 9246 H-InvDB: UBE2L6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2L6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2L6 gene:
    Search GeneIP for patents involving UBE2L6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for UBE2L6 (UbcH8)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBE2L6   OriGene RNAi products in human, mouse, rat for UBE2L6  
     OriGene qPCR primer pairs and template standards for UBE2L6   OriGene Protein Over-expression Lysate for UBE2L6  
     OriGene MassSpec something-or-other for UBE2L6   OriGene clones in human, mouse for UBE2L6  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBE2L6   OriGene Purified Protein for UBE2L6  
     OriGene ORF clones in mouse, rat for UBE2L6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBE2L6   OriGene Custom Protein Services for UBE2L6  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2L6
     QIAGEN SeqTarget long-range PCR primers for resequencing UBE2L6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2L6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2L6
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2L6
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2L6
     GenScript Custom Purified and Recombinant Proteins Services for UBE2L6 GenScript cDNA clones with any tag delivered in your preferred vector for UBE2L6
     GenScript Custom Assay Services for UBE2L6 GenScript Custom Superior Antibodies Services for UBE2L6
     GenScript Custom overexpressing Cell Line Services for UBE2L6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UBE2L6 promoter
     Search Chromatin IP Primers for UBE2L6
     RT2 qPCR Primer Assay in human, mouse, rat UBE2L6
     GNC Network for UBE2L6
     SABiosciences PCR Arrays including human, mouse, rat UBE2L6
     Search Tocris compounds for UBE2L6 (UB2L6)
     Proteins and Antibodies for UBE2L6
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for UBE2L6
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UBE2L6 antibodies
     UBE2L6 proteins
     UBE2L6 lysates
     Antibodies for UBE2L6
     See all of Abcam's Antibodies, Kits and Proteins for UBE2L6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UBE2L6




     Proteins for UBE2L6
     Antibodies for UBE2L6
     ELISAs for UBE2L6
     CLIAs for UBE2L6
     Search LifeMap BioReagents cell lines for UBE2L6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2L6
     SwitchGear 3'UTR luciferase reporter plasmids for UBE2L6
     SwitchGear Promoter luciferase reporter plasmids for UBE2L6
     ThermoFisher Antibodies for UBE2L6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2L6
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2L6
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2L6
    Customized:
     lentivirus for stable overexpression of UBE2L6
     lentivirus expression plasmids for stable overexpression of UBE2L6
     adenovirus for overexpression of UBE2L6
     LSBio Antibodies in human, mouse, rat for UBE2L6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBE2L6 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4