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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBE2L6 Gene

protein-coding GIFtS: 68
GCID: GC11M057319

ubiquitin-conjugating enzyme E2L 6

Explore 5 diseases affiliated with
UBE2L6 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2L 6¹ ²		RIG-B² ³
UBCH8¹ ² ³ ⁵		EC 6.3.2.19³ ⁸
Retinoic Acid-Induced Gene B Protein² ³		Retinoic Acid Induced Gene B Protein²
Ubiquitin Carrier Protein L6² ³		Ubiquitin/ISG15-Conjugating Enzyme E2 L6²
Ubiquitin-Protein Ligase L6² ³		UbcH8³

External Ids:	HGNC: 12490¹	Entrez Gene: 9246²	Ensembl: ENSG00000156587⁷	OMIM: 603890⁵	UniProtKB: O14933³

Export aliases for UBE2L6 gene to outside databases

Previous GC identifers: GC11M059713 GC11M058832 GC11M057571 GC11M057094 GC11M057075 GC11M053667

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2L6:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived

proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes

(E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2

ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the

UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

(provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933

Function: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced

ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3

Gene Wiki entry for UBE2L6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBE2L6 gene promoter:
AREB6 STAT1 CUTL1 Roaz
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBE2L6 promoter sequence

Search SABiosciences Chromatin IP Primers for UBE2L6

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2L6

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1

UBE2L6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2L6 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M057319: view genomic region (about GC identifiers)

Start:	57,319,129 bp from pter	End:	57,335,757 bp from pter
Size:	16,629 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933 (See protein sequence)

Recommended Name: Ubiquitin/ISG15-conjugating enzyme E2 L6

Size: 153 amino acids; 17769 Da

Subunit: Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated)

Sequence caution: Sequence=CAB64566.1; Type=Erroneous initiation;

3 PDB 3D structures from and Proteopedia for UBE2L6:

1WZV (3D)

1WZW (3D)

2KJH (3D)

Secondary accessions: A6NDM6 A8MY53 Q8N5D8 Q9UEZ0

Alternative splicing: 2 isoforms: O14933-1 O14933-2

Explore the universe of human proteins at neXtProt for UBE2L6: NX_O14933

Post-translational modifications:

ISGylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O14933

2 DME Specific Peptides for UBE2L6 (O14933)

KNAEEFT

TKIYHPN

UBE2L6 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_004214.1 NP_937826.1

ENSEMBL proteins:

ENSP00000341980 ENSP00000287156 ENSP00000435265 ENSP00000434348

Reactome Protein details: O14933
Human Recombinant Protein Products:

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	Novus Biologicals UBE2L6 Proteins Novus Biologicals UBE2L6 Lysates
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	Uscn Proteins for UBE2L6

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

UBE2L6 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBE2L6 for domains About GeneDecksing

3 InterPro domains/families:

IPR016135 UBQ-conjugating_enzyme/RWD

IPR023313 UBQ-conjugating_AS

IPR000608 UBQ-conjugat_E2

Graphical View of Domain Structure for InterPro Entry O14933

ProtoNet protein and cluster: O14933

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933

Function: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced

ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

Induction: By IFNB1/IFN-beta

Genatlas biochemistry entry for UBE2L6:

ubiquitin conjugating enzyme H8,identified in a two hybrid screen through specific interaction with E6AP (E3) ubiquitin

protein ligase in the E6-dependent ubiquination of TP53

Enzyme Number (IUBMB): EC 6.3.2.19¹ ²

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		hsa-miR-647 hsa-miR-4283 hsa-miR-125a-3p hsa-miR-331-3p
		SwitchGear 3'UTR luciferase reporter plasmid: UBE2L6 3' UTR sequence

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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2L6

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005515	protein binding	IPI	16709802
GO:0005524	ATP binding	--	--
GO:0016881	acid-amino acid ligase activity	--	--
GO:0019787	small conjugating protein ligase activity	--	--

UBE2L6 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for UBE2L6:

Synthetic lethal with c-Myc af

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Immune System

	Immune System	1.00			Innate Immune System	0.46
	Adaptive Immune System	0.59

RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1

	RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1	1.00			Immune System	0.70
	RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1	0.88

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Cytokine Signaling in Immune system

Cytokine Signaling in Immune system

1.00

Interferon Signaling

0.61

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for UBE2L6

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Proteolysis Putative ubiquitin pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2L6

	Ubiquitin-Proteasome Dependent Proteolysis
	Remodeling of Adherens Junctions

2 GeneGo (Thomson Reuters) Pathways for UBE2L6

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
	Proteolysis Putative ubiquitin pathway

2 BioSystems Pathways for UBE2L6

	Parkinsons Disease Pathway
	Parkin-Ubiquitin Proteasomal System pathway

5/15 Reactome Pathways for UBE2L6 (see all 15)

	Antiviral mechanism by IFN-stimulated genes
	Cytokine Signaling in Immune system
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	Immune System
	Polyubiquitination of substrate

2 Kegg Pathways (Kegg details for UBE2L6):

	Ubiquitin mediated proteolysis
	Parkinson's disease

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933

Pathway: Protein modification; protein ubiquitination

UBE2L6 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UBE2L6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/70 Interacting proteins for UBE2L6 (O14933^{1, 2, 3} ENSP00000287156⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARHGDIA	P52565²^,³, ENSP00000269321⁴	MINT-8276233 I2D: score=2 STRING: ENSP00000269321
RNF19B	Q6ZMZ0¹^,³, ENSP00000362555⁴	EBI-2129974,EBI-2466594 I2D: score=2 STRING: ENSP00000362555
RNF144B	Q7Z419²^,³, ENSP00000259939⁴	MINT-1771917 MINT-1771944 I2D: score=4 STRING: ENSP00000259939
FLNB	O75369²^,³, ENSP00000295956⁴	MINT-7288791 I2D: score=1 STRING: ENSP00000295956
NAMPT	P43490²^,³, ENSP00000222553⁴	MINT-6538769 I2D: score=1 STRING: ENSP00000222553

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	cellular protein modification process	TAS	9153201
GO:0016567	protein ubiquitination	--	--
GO:0019221	cytokine-mediated signaling pathway	TAS	--
GO:0019941	modification-dependent protein catabolic process	IEA	--
GO:0032020	ISG15-protein conjugation	IEA	--

UBE2L6 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UBE2L6

4 HMDB Compounds for UBE2L6 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about UBE2L6 / UB2L6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UBE2L6 gene (2 alternative transcripts):

NM_004223.4 NM_198183.2

Unigene Cluster for UBE2L6:

Ubiquitin-conjugating enzyme E2L 6

Hs.425777 [show with all ESTs]

Unigene Representative Sequence: NM_198183

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000340573(uc001nko.2) ENST00000287156(uc001nkn.2) ENST00000528275

ENST00000527022 ENST00000526659

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Additional cDNA sequence:

AF031141.1 AF061736.1 AK093462.1 AK129621.1 AK226165.1 AK315755.1 BC032491.1 CR457126.1

11 DOTS entries:

DT.447411 DT.100006077 DT.92410683 DT.101981816 DT.91754122 DT.95301343 DT.95301290 DT.91754123

DT.91754124 DT.95301342 DT.91824239

24/394 AceView cDNA sequences (see all 394):

BM694229 AI913308 AI796357 BU181223 BM920035 BU655909 AI222251 BE612485

BQ218026 BM904354 AK093462 AA306615 BU507974 BE740921 BE748060 CA445308

NM_198183 AI669283 BU625117 CA417588 BQ774439 BI914207 AL560616 CA307378

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2L6 About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:			-		-		-		-
SP2:					-		-		-
SP3:							-		-
SP4:									-
SP5:

ECgene alternative splicing isoforms for UBE2L6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBE2L6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCTTGCTTA

About this image

UBE2L6 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

CyT49 (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Mesendoderm-like cells (Generation of mesend...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UBE2L6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2L6

SOURCE GeneReport for Unigene cluster: Hs.425777

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933

Tissue specificity: Present in natural killer cells (at protein level)

SABiosciences Custom PCR Arrays for UBE2L6

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2L6 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NIZ6_CHICK⁶	ubiquitin-conjugating enzyme E2L 3	53(a)	possible ortholog	15(172260-356655)
lizard (Anolis carolinensis)	Reptilia	UBE2L3⁶ --	--	52(a) 51(a)	possible ortholog possible ortholog	GL343282.1(1138838-1141850) 1(91716499-91720951)
zebrafish (Danio rerio)	Actinopterygii	ube2l3a⁶ ube2l3b⁶	ubiquitin-conjugating enzyme E2L 3b	47(a) 41(a)	possible ortholog possible ortholog	10(3159004-3164911) 5(14539853-14556251)
fruit fly (Drosophila melanogaster)	Insecta	Ubc84D⁶ UbcD10⁶ (see all 3)	Ubiquitin conjugating enzyme 10 (see all 3)	50(a) 50(a) (see all 3)	possible ortholog possible ortholog (see all 3)	3R(3344542-3345178) 2R(13675912-13676914)
worm (Caenorhabditis elegans)	Secernentea	ubc-18⁶	UBiquitin Conjugating enzyme family member (ubc-18...	46(a)	possible ortholog	III(7067627-7068512)
thale cress (Arabidopsis thaliana)	eudicotyledons	UBC31⁶	ubiquitin-conjugating enzyme E2 D/E	35(a)	1 → many	1(13683663-13684952)

ENSEMBL Gene Tree for UBE2L6 (if available)
TreeFam Gene Tree for UBE2L6 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UBE2L6 gene

UBE2D3² ENSG00000258677² UBE2D1² UBE2D2² UBE2W² UBE2E3² UBE2D4² UBE2E1²

UBE2E2² UBE2L3²

18/20 SIMAP similar genes for UBE2L6 using alignment to 3 protein entries: UB2L6_HUMAN (see all proteins) (see all similar genes):

UBE2L3 HR6A UBE2H UBE2N UBE2A UBE2U

UBE2D3 UBE2D4 UBE2D2 UBE2B UBE2D1 UBE2M

UBE2T UBE2NL UBE2G2 UBE2I UBE2K UBE2W

UBE2L6 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190337085^1,2		--	57318786(+)	`CTCAAA/GAGACT`	2	--	ds500¹		0	--	--	--	--
rs181816716^1,2		--	57318870(+)	`TGGGCA/GACGGA`	2	--	ds500¹		0	--	--	--	--
rs12291337^1,2		--	57318873(+)	`gcgacG/Agagtg`	2	--	ds500¹		1		WA	118
rs201902591^1,2		--	57318889(+)	`CTGTC-/TTAAA TAAATAAATAAA`	2	--	ds500¹		0	--	--	--	--
rs112670295^1,2	C	--	57318890(+)	`TGTCT-/TAAAT AAATAAATAAAT`	2	--	ds500¹		1		CSA	2
rs113964786^1,2	C,	--	57318926(+)	`ATAAAT/AAAAAT`	2	--	ds500¹		2		WA	120
rs2729370^1,2	C,F,A,H,	--	57318943(+)	`GGGACG/ATCACC`	2	--	ds500¹		21		NS EA NA WA CSA	2345
rs140822122^1,2		--	57319144(+)	`TCTCTA/GACTTT`	2	--	ut3¹		0	--	--	--	--
rs5847^1,2	C,F,O,A,H,	--	57319339(+)	`ATAAAC/TGGTTT`	2	--	ut3¹		33		MN EA NA NS WA CSA	4665
rs201760468^1,2	C	--	57319379(+)	`GGCTTG/TGCTGA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for UBE2L6 (57319129 - 57335757 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBE2L6
1 CNV: 4744

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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UBE2L6 for disorders           About GeneDecksing

OMIM gene information: 603890    OMIM disorders: --

5 diseases for UBE2L6:    About MalaCards

cblc parkinson's disease pharyngitis leukemia

prostatitis

1 disease from the University of Copenhagen DISEASES database for UBE2L6:

Diverticulitis

Export disorders for UBE2L6 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for UBE2L6 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with UBE2L6)

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Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. (PubMed id 9153201)^{1, 2, 3, 9} Kumar S.... Howley P.M. (1997)
The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site. (PubMed id 19928833)^{1, 2, 9} Serniwka S.A. and Shaw G.S. (2009)
Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12. (PubMed id 10894956)^{1, 2, 9} Ardley H.C....Robinson P.A. (2000)
NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)^{1, 2, 9} Fortier J.M. and Kornbluth J. (2006)
The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PubMed id 16427630)^{1, 2, 9} Huang J.... Shu H.-B. (2006)
A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PubMed id 11237715)^{1, 2, 9} Niwa J.... Sobue G. (2001)
Ubiquitin conjugase UBCH8 targets active FMS-like tyr osine kinase 3 for proteasomal degradation. (PubMed id 20508617)^{1, 2} Buchwald M....KrAomer O.H. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. (PubMed id 15131269)^{1, 2} Zhao C.... Krug R.M. (2004)
The basis for selective E1-E2 interactions in the ISG15 conjugation system. (PubMed id 18583345)^{1, 9} Durfee L.A....Huibregtse J.M. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9246	HGNC: 12490	AceView: UBE2L6	Ensembl:ENSG00000156587	euGenes: HUgn9246
ECgene: UBE2L6	Kegg: 9246	H-InvDB: UBE2L6

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for UBE2L6	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UBE2L6 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for UBE2L6 gene:
Search GeneIP for patents involving UBE2L6

GeneCards and IP:
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UBE2L6 Gene

ubiquitin-conjugating enzyme E2L 6

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UBE2L6 Gene

ubiquitin-conjugating enzyme E2L 6

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