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UBE2L6 Gene

protein-coding   GIFtS: 66
GCID: GC11M057319

Ubiquitin-Conjugating Enzyme E2L 6

  See UBE2L6-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2L 61 2     RIG-B2 3
UBCH82 3 5     EC 6.3.2.193 8
Retinoic Acid-Induced Gene B Protein2 3     Retinoic Acid Induced Gene B Protein2
Ubiquitin Carrier Protein L62 3     Ubiquitin/ISG15-Conjugating Enzyme E2 L62
Ubiquitin-Protein Ligase L62 3     UbcH83

External Ids:    HGNC: 124901   Entrez Gene: 92462   Ensembl: ENSG000001565877   OMIM: 6038905   UniProtKB: O149333   

Export aliases for UBE2L6 gene to outside databases

Previous GC identifers: GC11M059713 GC11M058832 GC11M057571 GC11M057094 GC11M057075 GC11M053667


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2L6 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This
gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary
structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding
distinct isoforms have been found for this gene. (provided by RefSeq, May 2011)

GeneCards Summary for UBE2L6 Gene:
UBE2L6 (ubiquitin-conjugating enzyme E2L 6) is a protein-coding gene. Diseases associated with UBE2L6 include diverticulitis. GO annotations related to this gene include ubiquitin-protein ligase activity and ISG15 ligase activity. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933
Function: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the
E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of
FLT3

Gene Wiki entry for UBE2L6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2L6 gene promoter:
         AREB6   STAT1   CUTL1   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2L6 promoter sequence
   Search Chromatin IP Primers for UBE2L6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2L6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12.1

UBE2L6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2L6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M057319:  view genomic region     (about GC identifiers)

Start:
57,319,128 bp from pter      End:
57,335,803 bp from pter
Size:
16,676 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933 (See protein sequence)
Recommended Name: Ubiquitin/ISG15-conjugating enzyme E2 L6  
Size: 153 amino acids; 17769 Da
Subunit: Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated)
Sequence caution: Sequence=CAB64566.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for UBE2L6:
1WZV (3D)        1WZW (3D)        2KJH (3D)    
Secondary accessions: A6NDM6 A8MY53 Q8N5D8 Q9UEZ0
Alternative splicing: 2 isoforms:  O14933-1   O14933-2   

Explore the universe of human proteins at neXtProt for UBE2L6: NX_O14933

Explore proteomics data for UBE2L6 at MOPED

Post-translational modifications: 

  • ISGylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for UBE2L6 (O14933)
     KNAEEFT  TKIYHPN 


    See UBE2L6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_004214.1  NP_937826.1  

    ENSEMBL proteins: 
     ENSP00000341980   ENSP00000287156   ENSP00000435265   ENSP00000434348  
    Reactome Protein details: O14933

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry O14933

    ProtoNet protein and cluster: O14933

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2L6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2L6_HUMAN, O14933
    Function: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the
    E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of
    FLT3
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Induction: By IFNB1/IFN-beta

         Genatlas biochemistry entry for UBE2L6:
    ubiquitin conjugating enzyme H8,identified in a two hybrid screen through specific interaction with E6AP (E3)
    ubiquitin protein ligase in the E6-dependent ubiquination of TP53

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding IPI10085091
    GO:0016881acid-amino acid ligase activity ----
    GO:0019787small conjugating protein ligase activity ----
    GO:0042296ISG15 ligase activity IEA--
         
    Find genes that share ontologies with UBE2L6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2L6:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UBE2L6

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    Find genes that share ontologies with UBE2L6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2L6 About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    5Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57


    Find genes that share SuperPaths with UBE2L6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2L6
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    2 GeneGo (Thomson Reuters) Pathways for UBE2L6
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    2 BioSystems Pathways for UBE2L6
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway


    4 Reactome Pathways for UBE2L6
        Antigen processing: Ubiquitination & Proteasome degradation
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Negative regulators of RIG-I/MDA5 signaling
    ISG15 antiviral mechanism


    2 Kegg Pathways  (Kegg details for UBE2L6):
        Ubiquitin mediated proteolysis
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBE2L6
    Interactions:

        GeneGlobe Interaction Network for UBE2L6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2L6 (O149331, 2, 3 ENSP000002871564) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARHGDIAP525652, 3, ENSP000002693214MINT-8276233 I2D: score=2 STRING: ENSP00000269321
    RNF19BQ6ZMZ01, 3, ENSP000003625554EBI-2129974,EBI-2466594 I2D: score=2 STRING: ENSP00000362555
    ENSG00000237071P143733, ENSP000004052294I2D: score=2 STRING: ENSP00000405229
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464cellular protein modification process TAS9153201
    GO:0019221cytokine-mediated signaling pathway TAS--
    GO:0019941modification-dependent protein catabolic process IEA--
    GO:0032020ISG15-protein conjugation IEA--
    GO:0032480negative regulation of type I interferon production TAS--

    Find genes that share ontologies with UBE2L6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UBE2L6 (UB2L6)

    4 HMDB Compounds for UBE2L6    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2L6 gene (2 alternative transcripts): 
    NM_004223.4  NM_198183.2  

    Unigene Cluster for UBE2L6:

    Ubiquitin-conjugating enzyme E2L 6
    Hs.425777  [show with all ESTs]
    Unigene Representative Sequence: NM_198183
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000340573(uc001nko.2) ENST00000287156(uc001nkn.2) ENST00000528275
    ENST00000527022 ENST00000526659
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    Additional mRNA sequence: 

    AF031141.1 AF061736.1 AK093462.1 AK129621.1 AK226165.1 AK315755.1 BC032491.1 CR457126.1 

    11 DOTS entries:

    DT.447411  DT.100006077  DT.92410683  DT.101981816  DT.91754122  DT.95301343  DT.95301290  DT.91754123 
    DT.91754124  DT.95301342  DT.91824239 

    Selected AceView cDNA sequences (see all 394):

    BQ428118 AL560616 AI858014 BU679141 AI222251 BQ051009 BG471314 NM_004223 
    CA314466 BC032491 BM723083 BM313309 CR601863 BU733098 BG026285 BI914207 
    BQ774439 AF061736 CR609116 CA308361 CA307378 AA779527 BU521489 BQ010166 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2L6    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
    SP1:        -     -     -     -                                             
    SP2:              -     -     -                                             
    SP3:                    -     -                                             
    SP4:                          -                                             
    SP5:                                                                        


    ECgene alternative splicing isoforms for UBE2L6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2L6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTTGCTTA
    UBE2L6 Expression
    About this image


    UBE2L6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Atrioventricular Canal Cells Atrioventricular Canal
             Outflow Tract
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Lung (Respiratory System)
     
     Ovary (Reproductive System)
    UBE2L6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2L6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.425777

    UniProtKB/Swiss-Prot: UB2L6_HUMAN, O14933
    Tissue specificity: Present in natural killer cells (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE2L6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2l61 , 5 ubiquitin-conjugating enzyme E2L 61, 5 79.96(n)1
    76.47(a)1
      2 (49.45 cM)5
    567911  NM_019949.21  NP_064333.21 
     847988285 
    chicken
    (Gallus gallus)
    Aves UBE2L66
    ubiquitin-conjugating enzyme E2L 6
    38(a)
    1 ↔ 1
    5(16306938-16308177) ENSGALG00000029181
    lizard
    (Anolis carolinensis)
    Reptilia UBE2L66
    ubiquitin-conjugating enzyme E2L 6
    52(a)
    1 ↔ 1
    1(91716499-91720951)
    fruit fly
    (Drosophila melanogaster)
    Insecta UbcD106
    Ubiquitin conjugating enzyme 10
    51(a)
    1 → many
    2R(13675912-13676914)
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-186
    Protein UBC-18 (ubc-18) mRNA, complete cds
    47(a)
    1 → many
    III(7067687-7068570) WBGene00006713
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC46
    UBC56
    Ubiquitin-conjugating enzyme (E2), mediates degrad...
    Ubiquitin-conjugating enzyme that mediates selecti...
    36(a)
    35(a)
    many ↔ many
    many ↔ many
    II(406628-407169) YBR082C
    IV(569234-569770) YDR059C


    ENSEMBL Gene Tree for UBE2L6 (if available)
    TreeFam Gene Tree for UBE2L6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2L6 gene
    UBE2D32  UBE2D12  UBE2D22  UBE2E32  UBE2D42  UBE2L32  UBE2E12  UBE2E22  
    Selected SIMAP similar genes for UBE2L6 using alignment to 3 protein entries:     UB2L6_HUMAN (see all proteins) (see all similar genes):
    UBE2L3    HR6A    UBE2H    UBE2N    UBE2A    UBE2U
    UBE2D3    CDC34    UBE2D2    UBE2D4    UBE2M    UBE2B
    UBE2D1    UBE2T    UBE2NL    UBE2G2    UBE2I    UBE2K

    Find genes that share paralogs with UBE2L6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2L6 (see all 398)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1903370851,2
    --57318786(+) CTCAAA/GAGACT 2 -- ds50010--------
    rs1818167161,2
    --57318870(+) TGGGCA/GACGGA 2 -- ds50010--------
    rs122913371,2
    C,F--57318873(+) gcgacG/Agagtg 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs603377641,2
    C--57318889(+) CTGTCA/TTAAAT 2 -- ds50010--------
    rs2019025911,2
    --57318889(+) CTGTC-/TTAAA 
     TAAATAA
    ATAAA
    2 -- ds50010--------
    rs1126702951,2
    C--57318890(+) TGTCT-/TAAAT 
     AAATAAA
    TAAAT
    2 -- ds50011Minor allele frequency- TAAATAAATAAA:0.50CSA 2
    rs3753508731,2
    C--57318890(+) CTGTC-/TAA   
       ATAAA
    AAATA
    2 -- ds50010--------
    rs1139647861,2
    C,F--57318926(+) ATAAAT/AAAAAT 2 -- ds50012Minor allele frequency- A:0.04WA 120
    rs27293701,2
    C,F,A,H--57318943(+) GGGACG/ATCACC 2 -- ds500121Minor allele frequency- A:0.49NS EA NA WA CSA 2345
    rs1408221221,2
    C--57319144(+) TCTCTA/GACTTT 2 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2L6 (57319128 - 57335803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2L6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832163CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2L6
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2L6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603890    OMIM disorders: --

    1 disease for UBE2L6:    
    About MalaCards
    diverticulitis

    1 disease from the University of Copenhagen DISEASES database for UBE2L6:
    Diverticulitis

    Find genes that share disorders with UBE2L6           About GenesLikeMe


    Export disorders for UBE2L6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2L6 gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with UBE2L6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. (PubMed id 9153201)1, 2, 3, 9 Kumar S.... Howley P.M. (J. Biol. Chem. 1997)
    2. The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site. (PubMed id 19928833)1, 2, 9 Serniwka S.A. and Shaw G.S. (Biochemistry 2009)
    3. Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12. (PubMed id 10894956)1, 2, 9 Ardley H.C....Robinson P.A. (Cytogenet. Cell Genet. 2000)
    4. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PubMed id 16709802)1, 2, 9 Fortier J.M. and Kornbluth J. (J. Immunol. 2006)
    5. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PubMed id 16427630)1, 2, 9 Huang J.... Shu H.-B. (FEBS Lett. 2006)
    6. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PubMed id 11237715)1, 2, 9 Niwa J.... Sobue G. (Biochem. Biophys. Res. Commun. 2001)
    7. Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation. (PubMed id 20508617)1, 2 Buchwald M....Kramer O.H. (Leukemia 2010)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein. (PubMed id 15131269)1, 2 Zhao C.... Krug R.M. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    10. The basis for selective E1-E2 interactions in the ISG15 conjugation system. (PubMed id 18583345)1, 9 Durfee L.A....Huibregtse J.M. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9246 HGNC: 12490 AceView: UBE2L6 Ensembl:ENSG00000156587 euGenes: HUgn9246
    ECgene: UBE2L6 Kegg: 9246 H-InvDB: UBE2L6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2L6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2L6 gene:
    Search GeneIP for patents involving UBE2L6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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