Aliases for UBE2L6 Gene
External Ids for UBE2L6 Gene
Previous GeneCards Identifiers for UBE2L6 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
GeneCards Summary for UBE2L6 Gene
UBE2L6 (Ubiquitin Conjugating Enzyme E2 L6) is a Protein Coding gene. Among its related pathways are Ubiquitin-Proteasome Dependent Proteolysis and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L5P.
UniProtKB/Swiss-Prot for UBE2L6 Gene
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.