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Aliases for UBE2L6 Gene

Aliases for UBE2L6 Gene

  • Ubiquitin Conjugating Enzyme E2 L6 2 3 5
  • E2 Ubiquitin-Conjugating Enzyme L6 3 4
  • Ubiquitin Carrier Protein L6 3 4
  • Ubiquitin-Protein Ligase L6 3 4
  • UBCH8 3 4
  • RIG-B 3 4
  • Ubiquitin/ISG15-Conjugating Enzyme E2 L6 3
  • Retinoic Acid Induced Gene B Protein 3
  • Retinoic Acid-Induced Gene B Protein 4
  • Ubiquitin-Conjugating Enzyme E2L 6 2
  • Ubiquitin Conjugating Enzyme E2L 6 3
  • EC 6.3.2.19 56
  • EC 2.3.2.23 4

External Ids for UBE2L6 Gene

Previous GeneCards Identifiers for UBE2L6 Gene

  • GC11M059713
  • GC11M058832
  • GC11M057094
  • GC11M057075
  • GC11M057319
  • GC11M053667

Summaries for UBE2L6 Gene

Entrez Gene Summary for UBE2L6 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

GeneCards Summary for UBE2L6 Gene

UBE2L6 (Ubiquitin Conjugating Enzyme E2 L6) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L5.

UniProtKB/Swiss-Prot for UBE2L6 Gene

  • Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Gene Wiki entry for UBE2L6 Gene

Additional gene information for UBE2L6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2L6 Gene

Genomics for UBE2L6 Gene

GeneHancer (GH) Regulatory Elements for UBE2L6 Gene

Promoters and enhancers for UBE2L6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I057565 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 566.4 +0.7 718 4.9 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS REST KAT8 MIER3 ZNF610 UBE2L6 TIMM10 PPIAP42 SLC43A3 ZDHHC5 SMTNL1
GH11I057637 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -71.2 -71184 4.5 HDGF FOXA2 ARID4B SIN3A GLI4 ZNF48 YY1 ETS1 SLC30A9 GLIS2 ENSG00000254602 MIR130A UBE2L6 RPS4XP13 SERPING1 MED19 TIMM10 PRG3 YPEL4 OR9Q1
GH11I057529 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +37.6 37641 2.5 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 PIR39300 PIR40820 TIMM10 SSRP1 CLP1 MIR130A UBE2L6 RPS4XP13 ENSG00000254602 YPEL4
GH11I057760 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 4.4 -195.1 -195130 5.3 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 IRF4 YY1 SLC30A9 CTNND1 MED19 YPEL4 SELENOH ENSG00000254732 UBE2L6 SMTNL1 BTBD18 PIR53177 TMX2-CTNND1
GH11I057481 Enhancer 1 Ensembl ENCODE 6.6 +85.7 85653 2.2 RB1 ZFP64 KLF17 SIN3A RAD21 GLIS2 ZNF366 ZNF143 RUNX3 SMARCA5 TIMM10 SMTNL1 RTN4RL2 RN7SKP259 SLC43A1 ENSG00000254979 SLC43A3 P2RX3 SSRP1 UBE2L6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around UBE2L6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UBE2L6 gene promoter:

Genomic Locations for UBE2L6 Gene

Genomic Locations for UBE2L6 Gene
chr11:57,551,655-57,568,330
(GRCh38/hg38)
Size:
16,676 bases
Orientation:
Minus strand
chr11:57,319,128-57,335,803
(GRCh37/hg19)

Genomic View for UBE2L6 Gene

Genes around UBE2L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2L6 Gene

Proteins for UBE2L6 Gene

  • Protein details for UBE2L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14933-UB2L6_HUMAN
    Recommended name:
    Ubiquitin/ISG15-conjugating enzyme E2 L6
    Protein Accession:
    O14933
    Secondary Accessions:
    • A6NDM6
    • A8MY53
    • Q8N5D8
    • Q9UEZ0

    Protein attributes for UBE2L6 Gene

    Size:
    153 amino acids
    Molecular mass:
    17769 Da
    Quaternary structure:
    • Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated).
    SequenceCaution:
    • Sequence=CAB64566.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2L6 Gene

    Alternative splice isoforms for UBE2L6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2L6 Gene

Selected DME Specific Peptides for UBE2L6 Gene

O14933:
  • KNAEEFT
  • TKIYHPN

Post-translational modifications for UBE2L6 Gene

Other Protein References for UBE2L6 Gene

Domains & Families for UBE2L6 Gene

Gene Families for UBE2L6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UBE2L6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14933

UniProtKB/Swiss-Prot:

UB2L6_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2L6: view

Function for UBE2L6 Gene

Molecular function for UBE2L6 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme H8,identified in a two hybrid screen through specific interaction with E6AP (E3) ubiquitin protein ligase in the E6-dependent ubiquination of TP53
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
UniProtKB/Swiss-Prot Induction:
By IFNB1/IFN-beta.

Enzyme Numbers (IUBMB) for UBE2L6 Gene

Phenotypes From GWAS Catalog for UBE2L6 Gene

Gene Ontology (GO) - Molecular Function for UBE2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS 9153201
GO:0005515 protein binding IPI 10085091
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0019787 ubiquitin-like protein transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2L6: view
genes like me logo Genes that share phenotypes with UBE2L6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBE2L6 Gene

Localization for UBE2L6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2L6 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for UBE2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2L6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2L6 Gene

Pathways & Interactions for UBE2L6 Gene

genes like me logo Genes that share pathways with UBE2L6: view

UniProtKB/Swiss-Prot O14933-UB2L6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 9153201
GO:0016567 protein ubiquitination IEA --
GO:0019941 modification-dependent protein catabolic process IEA --
GO:0019985 translesion synthesis TAS --
GO:0032020 ISG15-protein conjugation IEA --
genes like me logo Genes that share ontologies with UBE2L6: view

No data available for SIGNOR curated interactions for UBE2L6 Gene

Drugs & Compounds for UBE2L6 Gene

(3) Drugs for UBE2L6 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for UBE2L6 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2L6: view

Transcripts for UBE2L6 Gene

Unigene Clusters for UBE2L6 Gene

Ubiquitin-conjugating enzyme E2L 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2L6 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for UBE2L6 Gene

GeneLoc Exon Structure for
UBE2L6
ECgene alternative splicing isoforms for
UBE2L6

Expression for UBE2L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2L6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2L6 Gene

This gene is overexpressed in Oral epithelium (14.4), Spleen (8.5), Monocytes (6.6), and Skin (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2L6 Gene



Protein tissue co-expression partners for UBE2L6 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2L6 Gene:

UBE2L6

SOURCE GeneReport for Unigene cluster for UBE2L6 Gene:

Hs.425777

mRNA Expression by UniProt/SwissProt for UBE2L6 Gene:

O14933-UB2L6_HUMAN
Tissue specificity: Present in natural killer cells (at protein level).

Evidence on tissue expression from TISSUES for UBE2L6 Gene

  • Nervous system(4.8)
  • Liver(4.4)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with UBE2L6: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2L6 Gene

Orthologs for UBE2L6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2L6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2L6 33 34
  • 99.35 (n)
dog
(Canis familiaris)
Mammalia UBE2L6 33 34
  • 79.96 (n)
mouse
(Mus musculus)
Mammalia Ube2l6 33 16 34
  • 79.96 (n)
rat
(Rattus norvegicus)
Mammalia Ube2l6 33
  • 78.87 (n)
cow
(Bos Taurus)
Mammalia UBE2L6 33 34
  • 78.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2L6 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2L6 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2L6 34
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta UbcD10 34
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-18 34
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 34
  • 36 (a)
ManyToMany
UBC5 34
  • 35 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11086 34
  • 51 (a)
OneToMany
Species where no ortholog for UBE2L6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBE2L6 Gene

ENSEMBL:
Gene Tree for UBE2L6 (if available)
TreeFam:
Gene Tree for UBE2L6 (if available)

Paralogs for UBE2L6 Gene

(20) SIMAP similar genes for UBE2L6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBE2L6: view

Variants for UBE2L6 Gene

Sequence variations from dbSNP and Humsavar for UBE2L6 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000182583 -- 57,568,997(-) A/C upstream_transcript_variant
rs1000318636 -- 57,553,782(-) C/T intron_variant
rs1000517398 -- 57,566,038(-) T/C intron_variant
rs1000540300 -- 57,565,590(-) C/T intron_variant
rs1000646333 -- 57,559,473(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2L6 Gene

Variant ID Type Subtype PubMed ID
nsv832163 CNV gain 17160897

Variation tolerance for UBE2L6 Gene

Residual Variation Intolerance Score: 71.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.18; 4.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UBE2L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2L6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2L6 Gene

Disorders for UBE2L6 Gene

Additional Disease Information for UBE2L6

No disorders were found for UBE2L6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2L6 Gene

Publications for UBE2L6 Gene

  1. Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity. (PMID: 9153201) Kumar S … Howley PM (The Journal of biological chemistry 1997) 2 3 4 22 58
  2. The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site. (PMID: 19928833) Serniwka SA … Shaw GS (Biochemistry 2009) 3 4 22 58
  3. NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase. (PMID: 16709802) Fortier JM … Kornbluth J (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 22 58
  4. The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis. (PMID: 16427630) Huang J … Shu HB (FEBS letters 2006) 3 4 22 58
  5. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PMID: 11237715) Niwa J … Sobue G (Biochemical and biophysical research communications 2001) 3 4 22 58

Products for UBE2L6 Gene

Sources for UBE2L6 Gene

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