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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2L3 Gene

protein-coding   GIFtS: 69
GCID: GC22P021903

Ubiquitin-Conjugating Enzyme E2L 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin-Conjugating Enzyme E2L 31 2     E2-F12
UBCH72 3 5     UbcM42
Ubiquitin Carrier Protein L32 3     Ubiquitin-Conjugating Enzyme E2 L32
Ubiquitin-Conjugating Enzyme E2-F12 3     Ubiquitin-Conjugating Enzyme UBCH72
Ubiquitin-Protein Ligase L32 3     UBCE73
L-UBC2 3     UbcH73
EC 6.3.2.193 8     

External Ids:    HGNC: 124881   Entrez Gene: 73322   Ensembl: ENSG000001856517   OMIM: 6037215   UniProtKB: P680363   
ORGUL members:         
NONCODE14:n408250 n408251      

Export aliases for UBE2L3 gene to outside databases

Previous GC identifers: GC22P018620 GC22P020246 GC22P004880


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2L3 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This
gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate
in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for UBE2L3 Gene: 
UBE2L3 (ubiquitin-conjugating enzyme E2L 3) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with UBE2L3 include cblc, and machado-joseph disease, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and enzyme binding. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
Function: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3
ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it
lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3
enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the
E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked
polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated
during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors
transcriptional activity. May play a role in myelopoiesis

Gene Wiki entry for UBE2L3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011520.12  NC_018933.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2L3 gene promoter:
         p53   p300   NCX/Ncx   Brachyury   AP-4   Egr-4   CRE-BP1   COMP1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2L3 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2L3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

UBE2L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2L3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021903:  view genomic region     (about GC identifiers)

Start:
21,903,736 bp from pter      End:
21,978,323 bp from pter
Size:
74,588 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for UBE2L3

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 L3  
Size: 154 amino acids; 17862 Da
Subunit: Interacts with PARK2; involved in ubiquitination and degradation of misfolded proteins. Interacts with
UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL,
ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with
NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with
NR3C1
Subcellular location: Nucleus. Cytoplasm
Caution: PubMed:10760570 reported that UBE2L1, UBE2L2 and UBE2L4 are most likely pseudogenes and the only
expressed member of this subfamily seems to be UBE2L3
4 PDB 3D structures from and Proteopedia for UBE2L3:
1C4Z (3D)        1FBV (3D)        3SQV (3D)        3SY2 (3D)    
Secondary accessions: B2R4A7 B4DDG1 B4DSZ4 E7EWS7 P51966 P70653 Q9HAV1
Alternative splicing: 3 isoforms:  P68036-1   P68036-2   P68036-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2L3: NX_P68036

Explore proteomics data for UBE2L3 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to
    ubiquitin-dependent proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P68036

  • 4 DME Specific Peptides for UBE2L3 (P68036)
     YPFKPPK  KNAEEFT  TKIYHPN  KGAFRIEINFP 

    UBE2L3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2L3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001243284.1  NP_001243285.1  NP_003338.1  

    ENSEMBL proteins: 
     ENSP00000344259   ENSP00000400906   ENSP00000445931  
    Reactome Protein details: P68036
    Human Recombinant Protein Products for UBE2L3: 
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    OriGene Protein Over-expression Lysate for UBE2L3
    OriGene MassSpec for UBE2L3 
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    Novus Biologicals UBE2L3 Protein
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    ProSpec Recombinant Protein for UBE2L3
    Cloud-Clone Corp. Proteins for UBE2L3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS8563171
    GO:0005634nucleus IDA11278816
    GO:0005737cytoplasm IDA11278816

    UBE2L3 for ontologies           About GeneDecksing



    UBE2L3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P68036

    ProtoNet protein and cluster: P68036

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Domain: In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are
    absent: Pro and a His residues are present instead of an Asp and an Asp residues in positions 88 and
    119,respectively
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2L3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2L3_HUMAN, P68036
    Function: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3
    ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it
    lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3
    enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the
    E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked
    polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated
    during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors
    transcriptional activity. May play a role in myelopoiesis
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2L3:
    ubiquitin conjugating enzyme UBE2L3,homologous to L-UBC (UBE2L1)

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA15367689
    GO:0004842ubiquitin-protein ligase activity TAS8563171
    GO:0005515protein binding IPI10888878
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2L3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2L3:
     Increased cell death HMECs cel  Increased number of cells in m  Upregulation of NF-kappaB path 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ube2l3):
     cardiovascular system  embryogenesis  growth/size  mortality/aging 

    UBE2L3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2L3 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2L3 
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    miRNA
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    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2L3 (see all 58):
    hsa-miR-21* hsa-miR-607 hsa-miR-488 hsa-miR-3653 hsa-miR-766 hsa-miR-500a hsa-miR-342-3p hsa-miR-409-5p
    SwitchGear 3'UTR luciferase reporter plasmidUBE2L3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2L3 About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4Proteolysis Putative ubiquitin pathway
    Proteolysis Putative ubiquitin pathway0.97
    5Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for UBE2L3
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2L3
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions
    Parkinson's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for UBE2L3
        Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for UBE2L3
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    4 BioSystems Pathways for UBE2L3
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway
    Alpha-synuclein signaling
    BARD1 signaling events


    4        Reactome Pathways for UBE2L3
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    2         Kegg Pathways  (Kegg details for UBE2L3):
        Ubiquitin mediated proteolysis
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Pathway: Protein modification; protein ubiquitination


    UBE2L3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2L3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/80 Interacting proteins for UBE2L3 (P680361, 2, 3 ENSP000003442594) via UniProtKB, MINT, STRING, and/or I2D (see all 80)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARK2O602602, 3, ENSP000003558654MINT-8214139 I2D: score=4 STRING: ENSP00000355865
    RNF19BQ6ZMZ01, 3, ENSP000003625554EBI-711173,EBI-2466594 I2D: score=2 STRING: ENSP00000362555
    MAPK6Q166592, 3MINT-8262143 I2D: score=2 
    ENSG00000224994Q9HCM93, ENSP000004119494I2D: score=2 STRING: ENSP00000411949
    ENSG00000232839Q9HCM93, ENSP000003983554I2D: score=2 STRING: ENSP00000398355
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA10888878
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IMP15367689
    GO:0006464cellular protein modification process TAS8576257
    GO:0006511ubiquitin-dependent protein catabolic process TAS8563171

    UBE2L3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBE2L3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UBE2L3 (UB2L3)

    4 HMDB Compounds for UBE2L3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 Novoseek inferred chemical compound relationships for UBE2L3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mg 132 61.5 4 17003263 (1)
    cysteine 1.38 3 9990509 (1), 10501966 (1)

    Search CenterWatch for drugs/clinical trials and news about UBE2L3 / UB2L3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for UBE2L3 gene (4 alternative transcripts): 
    NM_001256355.1  NM_001256356.1  NM_003347.3  NM_198157.1  

    Unigene Cluster for UBE2L3:

    Ubiquitin-conjugating enzyme E2L 3
    Hs.108104  [show with all ESTs]
    Unigene Representative Sequence: AK125396
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342192(uc002zuz.1 uc002zva.1 uc011aig.2) ENST00000496722
    ENST00000458578 ENST00000545681

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    Additional mRNA sequence: 

    AJ000519.1 AK125396.1 AK291083.1 AK293179.1 AK299985.1 AK311761.1 BC053368.1 CR456606.1 
    NR_028436.2 NR_046082.1 S81003.1 X92962.1 

    24/44 DOTS entries (see all 44):

    DT.449914  DT.97768456  DT.100849248  DT.100849294  DT.120650536  DT.120650589  DT.100687448  DT.120786431 
    DT.92461107  DT.95306212  DT.100862801  DT.120786832  DT.95306224  DT.100870772  DT.95306214  DT.100687447 
    DT.100687442  DT.100851801  DT.95306272  DT.100643363  DT.100694529  DT.100856729  DT.92461117  DT.100775656 

    24/986 AceView cDNA sequences (see all 986):

    CB321953 CD365772 AI141478 AI609632 BG255126 AI660694 X92962 AA297834 
    NM_003347 AW820592 CR625640 CF265046 BG260308 BQ286250 AA291075 BQ723433 
    CF265012 BU623864 AI375811 BG763048 AI017704 AJ000519 BQ050945 AI696433 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2L3 expression in normal human tissues (normalized intensities)      UBE2L3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTCAGGGT
    UBE2L3 Expression
    About this image


    UBE2L3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             postcentral gyrus   
     
     Stomach (Gastrointestinal Tract)    fully expand to see all 2 entries
             stomach, upper ; glandular cells   
     
     Colon (Gastrointestinal Tract)
             colon ; glandular cells   
     
     Kidney (Urinary System)
             kidney ; cells in tubules   

    See UBE2L3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2L3

    SOURCE GeneReport for Unigene cluster: Hs.108104

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Tissue specificity: Ubiquitous, with highest expression in testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2L3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBE2L3 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2l31 , 5 ubiquitin-conjugating enzyme E2L 31, 5 96.54(n)1
    100(a)1
      16 (10.63 cM)5
    221951  NM_009456.21  NP_033482.11 
     171520135 
    chicken
    (Gallus gallus)
    Aves UBE2L31 ubiquitin-conjugating enzyme E2L 3 94.81(n)
    100(a)
      416769  NM_001006180.1  NP_001006180.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2L36
    Uncharacterized protein
    95(a)
    1 ↔ 1
    GL343282.1(1138838-1145337)
    African clawed frog
    (Xenopus laevis)
    Amphibia BM262438.12   -- 86.8(n)    BM262438.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.274102 Danio rerio similar to ubiquitin-conjugating enzyme more 85.24(n)    BC056724.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta UbcD103 ubiquitin cycle ubiquitin conjugating
    enzyme
    74(a)
    (best of 3)
      54E9   --
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-183   -- 59(a)   III(7139506-7140546)   --


    ENSEMBL Gene Tree for UBE2L3 (if available)
    TreeFam Gene Tree for UBE2L3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2L3 gene
    UBE2D32  UBE2L62  UBE2D12  UBE2D22  UBE2E32  UBE2D42  UBE2E12  UBE2E22  
    18/22 SIMAP similar genes for UBE2L3 using alignment to 1 protein entry:     UB2L3_HUMAN(see all similar genes):
    UBE2L6    UBE2D4    UBE2D2    UBE2D3    HR6A    UBE2D1
    UBE2A    UBE2N    UBE2H    UBE2E3    UBE2B    UBE2E2
    UBE2NL    UBE2E1    UBE2T    UBE2K    UBE2G1    UBE2G2

    UBE2L3 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for UBE2L3 (see all 6)
    PGOHUM00000239368 PGOHUM00000239451 PGOHUM00000248233 PGOHUM00000234491 PGOHUM00000245927


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1500 SNPs in UBE2L3 are shown (see all 1500)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8617871,2
    C--5866183(-) gacagA/Ggtttt 3 -- us2k10--------
    rs1910917001,2
    --5866280(+) TGAACA/CCGGGA 3 -- us2k10--------
    rs1830126811,2
    C--5866293(+) CAGAGA/GTTACA 3 -- us2k10--------
    rs794866761,2
    C--5866301(+) ACAGTG/TAGCTG 3 -- us2k10--------
    rs1507990571,2
    --5866389(+) AAAAA-/GAGAAAAA 4 -- us2k10--------
    rs1422486361,2
    --5866426(+) TCTGAA/GGCTAT 4 -- us2k10--------
    rs1136920451,2
    C,F--5866632(+) AGTGCG/AGTGGC 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1851538051,2
    --5866637(+) AGTGGC/TGCGGA 4 -- us2k10--------
    rs1910521281,2
    --5866639(+) TGGCGC/TGGACT 4 -- us2k10--------
    rs1832871121,2
    --5866717(+) GATTAC/TGTTCG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2L3 (21903736 - 21978323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for UBE2L3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv914458CNV Loss21882294
    nsv428386CNV Loss18775914
    dgv4881n71CNV Loss21882294
    nsv834145CNV Loss17160897
    nsv7350OTHER Inversion18451855
    nsv511071OTHER Inversion20534489

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603721    OMIM disorders: --

    19 diseases for UBE2L3:    About MalaCards
    cblc    machado-joseph disease    gigantism    mantle cell lymphoma
    papilloma    keloids    celiac disease    fanconi's anemia
    parkinson's disease    crohn's disease    systemic lupus erythematosus    alzheimer's disease
    lupus erythematosus    anemia    hepatitis b    rheumatoid arthritis
    arthritis    hepatocellular carcinoma    hepatitis


    UBE2L3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for UBE2L3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    papilloma 41.9 2 8563171 (1), 10760570 (1)
    alzheimers disease 0 1 8563171 (1)

    Genetic Association Database (GAD): UBE2L3
    Human Genome Epidemiology (HuGE) Navigator: UBE2L3 (5 documents)

    Export disorders for UBE2L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2L3 gene, integrated from 9 sources (see all 189):
    (articles sorted by number of sources associating them with UBE2L3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3. (PubMed id 9693040)1, 2, 3, 9 Moynihan T.P....Robinson P.A. (1998)
    2. Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7. (PubMed id 10760570)1, 2, 9 Ardley H.C.... Robinson P.A. (2000)
    3. UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation. (PubMed id 17003263)1, 2, 9 Garside H....Ray D. (2006)
    4. Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. (PubMed id 18946090)1, 2, 9 Whitcomb E.A....Taylor A. (2009)
    5. The ubiquitin ligase Triad1 inhibits myelopoiesis thr ough UbcH7 and Ubc13 interacting domains. (PubMed id 19340006)1, 2, 9 Marteijn J.A....van der Reijden B.A. (2009)
    6. Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. (PubMed id 8672131)1, 3, 9 Moynihan T.P....Robinson P.A. (1996)
    7. A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. (PubMed id 8563171)1, 2, 9 Robinson P.A.... Markham A.F. (1995)
    8. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. (PubMed id 11278816)1, 2, 9 Ardley H.C.... Robinson P.A. (2001)
    9. The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. (PubMed id 15367689)1, 2, 9 Verma S....Nawaz Z. (2004)
    10. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PubMed id 11237715)1, 2, 9 Niwa J.... Sobue G. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7332 HGNC: 12488 AceView: UBE2L3 Ensembl:ENSG00000185651 euGenes: HUgn7332
    ECgene: UBE2L3 Kegg: 7332 H-InvDB: UBE2L3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2L3 gene:
    Search GeneIP for patents involving UBE2L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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