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UBE2L3 Gene

protein-coding   GIFtS: 69
GCID: GC22P021903

Ubiquitin-Conjugating Enzyme E2L 3

  See UBE2L3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin-Conjugating Enzyme E2L 31 2     E2-F12
UBCH72 3 5     UbcM42
Ubiquitin Carrier Protein L32 3     Ubiquitin-Conjugating Enzyme E2 L32
Ubiquitin-Conjugating Enzyme E2-F12 3     Ubiquitin-Conjugating Enzyme UBCH72
Ubiquitin-Protein Ligase L32 3     UBCE73
L-UBC2 3     UbcH73
EC 6.3.2.193 8     

External Ids:    HGNC: 124881   Entrez Gene: 73322   Ensembl: ENSG000001856517   OMIM: 6037215   UniProtKB: P680363   
ORGUL members:         

Export aliases for UBE2L3 gene to outside databases

Previous GC identifers: GC22P018620 GC22P020246 GC22P004880


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2L3 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This
gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate
in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for UBE2L3 Gene:
UBE2L3 (ubiquitin-conjugating enzyme E2L 3) is a protein-coding gene. Diseases associated with UBE2L3 include keloid formation. GO annotations related to this gene include ubiquitin-protein ligase activity and transcription coactivator activity. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
Function: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3
ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it
lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3
enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the
E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked
polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated
during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors
transcriptional activity. May play a role in myelopoiesis

Gene Wiki entry for UBE2L3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2L3 gene promoter:
         p53   p300   NCX/Ncx   Brachyury   AP-4   Egr-4   CRE-BP1   COMP1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2L3 promoter sequence
   Search Chromatin IP Primers for UBE2L3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

UBE2L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2L3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021903:  view genomic region     (about GC identifiers)

Start:
21,903,736 bp from pter      End:
21,978,323 bp from pter
Size:
74,588 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for UBE2L3

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 L3  
Size: 154 amino acids; 17862 Da
Subunit: Interacts with PARK2; involved in ubiquitination and degradation of misfolded proteins. Interacts with
UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL,
ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with
NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with
NR3C1
Caution: PubMed:10760570 reported that UBE2L1, UBE2L2 and UBE2L4 are most likely pseudogenes and the only
expressed member of this subfamily seems to be UBE2L3
4 PDB 3D structures from and Proteopedia for UBE2L3:
1C4Z (3D)        1FBV (3D)        3SQV (3D)        3SY2 (3D)    
Secondary accessions: B2R4A7 B4DDG1 B4DSZ4 E7EWS7 P51966 P70653 Q9HAV1
Alternative splicing: 3 isoforms:  P68036-1   P68036-2   P68036-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2L3: NX_P68036

Explore proteomics data for UBE2L3 at MOPED

Post-translational modifications: 

  • Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to
    ubiquitin-dependent proteasomal degradation1
  • Ubiquitination2 at Lys9, Lys20, Lys64, Lys67, Lys71, Lys73, Lys82, Lys100, Lys131
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for UBE2L3 (P68036)
     YPFKPPK  KNAEEFT  TKIYHPN  KGAFRIEINFP 


    See UBE2L3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243284.1  NP_001243285.1  NP_003338.1  

    ENSEMBL proteins: 
     ENSP00000344259   ENSP00000400906   ENSP00000445931  
    Reactome Protein details: P68036

    UBE2L3 Human Recombinant Protein Products:

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    Novus Biologicals UBE2L3 Protein
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBE2L3
    Cloud-Clone Corp. Proteins for UBE2L3

     
    Search eBioscience for Proteins for UBE2L3 

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    UBE2L3 Assay Products:

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    Search eBioscience for ELISAs for UBE2L3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry P68036

    ProtoNet protein and cluster: P68036

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Domain: In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are
    absent: Pro and a His residues are present instead of an Asp and an Asp residues in positions 88 and
    119,respectively
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2L3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2L3_HUMAN, P68036
    Function: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3
    ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it
    lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3
    enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the
    E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked
    polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated
    during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors
    transcriptional activity. May play a role in myelopoiesis
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2L3:
    ubiquitin conjugating enzyme UBE2L3,homologous to L-UBC (UBE2L1)

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA15367689
    GO:0004842ubiquitin-protein ligase activity TAS8563171
    GO:0005515protein binding IPI10888878
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with UBE2L3           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2L3:
     Increased cell death HMECs cel  Increased number of cells in m  Upregulation of NF-kappaB path 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ube2l3):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging 

    Find genes that share phenotypes with UBE2L3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2L3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2L3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2L3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2L3

    miRNA
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    miRTarBase miRNAs that target UBE2L3:
    hsa-mir-93-5p (MIRT048772), hsa-mir-122-5p (MIRT023267), hsa-mir-423-5p (MIRT038073)

    Block miRNA regulation of human, mouse, rat UBE2L3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2L3 (see all 58):
    hsa-miR-21* hsa-miR-607 hsa-miR-488 hsa-miR-3653 hsa-miR-766 hsa-miR-500a hsa-miR-342-3p hsa-miR-409-5p
    SwitchGear 3'UTR luciferase reporter plasmidUBE2L3 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for UBE2L3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2L3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UB2L3_HUMAN, P68036: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS8563171
    GO:0005634nucleus IDA11278816
    GO:0005737cytoplasm IDA11278816

    Find genes that share ontologies with UBE2L3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2L3 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    4CDK-mediated phosphorylation and removal of Cdc6
    Parkinson's Disease Pathway0.31
    5Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis


    Find genes that share SuperPaths with UBE2L3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2L3
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions
    Parkinson's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for UBE2L3
        Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for UBE2L3
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    4 BioSystems Pathways for UBE2L3
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway
    BARD1 signaling events
    Alpha-synuclein signaling


    1 Reactome Pathway for UBE2L3
        Antigen processing: Ubiquitination & Proteasome degradation


    2 Kegg Pathways  (Kegg details for UBE2L3):
        Ubiquitin mediated proteolysis
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2L3: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2L3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2L3 (P680361, 2, 3 ENSP000003442594) via UniProtKB, MINT, STRING, and/or I2D (see all 85)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARK2O602602, 3, ENSP000003558654MINT-8214139 I2D: score=4 STRING: ENSP00000355865
    RNF19BQ6ZMZ01, 3, ENSP000003625554EBI-711173,EBI-2466594 I2D: score=2 STRING: ENSP00000362555
    MAPK6Q166592, 3MINT-8262143 I2D: score=2 
    ENSG00000224994Q9HCM93, ENSP000004119494I2D: score=2 STRING: ENSP00000411949
    ENSG00000232839Q9HCM93, ENSP000003983554I2D: score=2 STRING: ENSP00000398355
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA10888878
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IMP15367689
    GO:0006464cellular protein modification process TAS8576257
    GO:0006511ubiquitin-dependent protein catabolic process TAS8563171

    Find genes that share ontologies with UBE2L3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2L3 (UB2L3)

    4 HMDB Compounds for UBE2L3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 Novoseek inferred chemical compound relationships for UBE2L3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mg 132 61.5 4 17003263 (1)
    cysteine 1.38 3 9990509 (1), 10501966 (1)



    Find genes that share compounds with UBE2L3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2L3 gene (4 alternative transcripts): 
    NM_001256355.1  NM_001256356.1  NM_003347.3  NM_198157.1  

    Unigene Cluster for UBE2L3:

    Ubiquitin-conjugating enzyme E2L 3
    Hs.108104  [show with all ESTs]
    Unigene Representative Sequence: AK125396
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342192(uc002zuz.1 uc002zva.1 uc011aig.2) ENST00000496722
    ENST00000458578 ENST00000545681
    miRNA
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    hsa-miR-21* hsa-miR-607 hsa-miR-488 hsa-miR-3653 hsa-miR-766 hsa-miR-500a hsa-miR-342-3p hsa-miR-409-5p
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    Addgene plasmids for UBE2L3 
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      QuantiTect SYBR Green Assays in human, mouse, rat UBE2L3
      QuantiFast Probe-based Assays in human, mouse, rat UBE2L3

    Additional mRNA sequence: 

    AJ000519.1 AK125396.1 AK291083.1 AK293179.1 AK299985.1 AK311761.1 BC053368.1 CR456606.1 
    NR_028436.2 NR_046082.1 S81003.1 X92962.1 

    Selected DOTS entries (see all 44):

    DT.449914  DT.97768456  DT.100849248  DT.100849294  DT.120650536  DT.120650589  DT.100687448  DT.120786431 
    DT.92461107  DT.95306212  DT.100862801  DT.120786832  DT.95306224  DT.100870772  DT.95306214  DT.100687447 
    DT.100687442  DT.100851801  DT.95306272  DT.100643363  DT.100694529  DT.100856729  DT.92461117  DT.100775656 

    Selected AceView cDNA sequences (see all 986):

    CF265183 AW820592 BX398031 BM662508 BU076225 AU280766 BI908761 CR611646 
    CF265046 BM463318 W84311 AA040008 BM672608 AA296864 NM_003347 BQ423112 
    CB243722 CB126644 BX400707 BU680751 BQ050945 AJ000519 BQ422172 CR611871 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTCAGGGT
    UBE2L3 Expression
    About this image


    UBE2L3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
    UBE2L3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2L3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.108104

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Tissue specificity: Ubiquitous, with highest expression in testis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2L3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE2L3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2l31 , 5 ubiquitin-conjugating enzyme E2L 31, 5 96.54(n)1
    100(a)1
      16 (10.63 cM)5
    221951  NM_009456.21  NP_033482.11 
     171520135 
    chicken
    (Gallus gallus)
    Aves UBE2L31 ubiquitin-conjugating enzyme E2L 3 94.81(n)
    100(a)
      416769  NM_001006180.1  NP_001006180.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2L36
    ubiquitin-conjugating enzyme E2L 3
    95(a)
    1 ↔ 1
    GL343282.1(1138838-1145337)
    African clawed frog
    (Xenopus laevis)
    Amphibia BM262438.12   -- 86.8(n)    BM262438.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.274102 Danio rerio similar to ubiquitin-conjugating enzyme more 85.24(n)    BC056724.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta UbcD103 ubiquitin cycle ubiquitin conjugating
    enzyme
    74(a)
    (best of 3)
      54E9   --
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-183   -- 59(a)   III(7139506-7140546)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC46
    UBC56
    Ubiquitin-conjugating enzyme (E2), mediates degrad...
    Ubiquitin-conjugating enzyme that mediates selecti...
    39(a)
    37(a)
    many ↔ many
    many ↔ many
    II(406628-407169) YBR082C
    IV(569234-569770) YDR059C


    ENSEMBL Gene Tree for UBE2L3 (if available)
    TreeFam Gene Tree for UBE2L3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2L3 gene
    UBE2D32  UBE2L62  UBE2D12  UBE2D22  UBE2E32  UBE2D42  UBE2E12  UBE2E22  
    Selected SIMAP similar genes for UBE2L3 using alignment to 1 protein entry:     UB2L3_HUMAN(see all similar genes):
    UBE2L6    UBE2D4    UBE2D2    UBE2D3    HR6A    UBE2D1
    UBE2A    UBE2N    UBE2H    UBE2E3    UBE2B    UBE2E2
    UBE2NL    UBE2T    UBE2E1    UBE2K    UBE2G1    UBE2G2

    Find genes that share paralogs with UBE2L3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for UBE2L3 (see all 6)
    PGOHUM00000239368 PGOHUM00000239451 PGOHUM00000248233 PGOHUM00000234491 PGOHUM00000245927


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2L3 (see all 1500)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8617871,2
    C--5866183(-) gacagA/Ggtttt 3 -- us2k10--------
    rs1910917001,2
    --5866280(+) TGAACA/CCGGGA 3 -- us2k10--------
    rs1830126811,2
    C--5866293(+) CAGAGA/GTTACA 3 -- us2k10--------
    rs794866761,2
    C--5866301(+) ACAGTG/TAGCTG 3 -- us2k10--------
    rs1507990571,2
    --5866389(+) AAAAA-/GAGAAAAA 4 -- us2k10--------
    rs1422486361,2
    --5866426(+) TCTGAA/GGCTAT 4 -- us2k10--------
    rs1136920451,2
    C,F--5866632(+) AGTGCG/AGTGGC 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1851538051,2
    --5866637(+) AGTGGC/TGCGGA 4 -- us2k10--------
    rs1910521281,2
    --5866639(+) TGGCGC/TGGACT 4 -- us2k10--------
    rs1832871121,2
    --5866717(+) GATTAC/TGTTCG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2L3 (21903736 - 21978323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for UBE2L3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv914458CNV Loss21882294
    nsv428386CNV Loss18775914
    dgv4881n71CNV Loss21882294
    nsv834145CNV Loss17160897
    nsv7350OTHER Inversion18451855
    nsv511071OTHER Inversion20534489

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2L3
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2L3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603721    OMIM disorders: --

    1 disease for UBE2L3:    
    About MalaCards
    keloid formation


    Find genes that share disorders with UBE2L3           About GenesLikeMe

    2 Novoseek inferred disease relationships for UBE2L3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    papilloma 41.9 2 8563171 (1), 10760570 (1)
    alzheimers disease 0 1 8563171 (1)

    Genetic Association Database (GAD): UBE2L3
    Human Genome Epidemiology (HuGE) Navigator: UBE2L3 (5 documents)

    Export disorders for UBE2L3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2L3 gene, integrated from 10 sources (see all 191):
    (articles sorted by number of sources associating them with UBE2L3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3. (PubMed id 9693040)1, 2, 3, 9 Moynihan T.P....Robinson P.A. (Genomics 1998)
    2. Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7. (PubMed id 10760570)1, 2, 9 Ardley H.C.... Robinson P.A. (Biochim. Biophys. Acta 2000)
    3. UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation. (PubMed id 17003263)1, 2, 9 Garside H.... Ray D. (J. Endocrinol. 2006)
    4. Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. (PubMed id 18946090)1, 2, 9 Whitcomb E.A.... Taylor A. (Mol. Biol. Cell 2009)
    5. The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains. (PubMed id 19340006)1, 2, 9 Marteijn J.A.... van der Reijden B.A. (Leukemia 2009)
    6. Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. (PubMed id 8672131)1, 3, 9 Moynihan T.P....Robinson P.A. (Mamm. Genome 1996)
    7. A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. (PubMed id 8563171)1, 2, 9 Robinson P.A.... Markham A.F. (Mamm. Genome 1995)
    8. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. (PubMed id 11278816)1, 2, 9 Ardley H.C.... Robinson P.A. (J. Biol. Chem. 2001)
    9. The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. (PubMed id 15367689)1, 2, 9 Verma S.... Nawaz Z. (Mol. Cell. Biol. 2004)
    10. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PubMed id 11237715)1, 2, 9 Niwa J.... Sobue G. (Biochem. Biophys. Res. Commun. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7332 HGNC: 12488 AceView: UBE2L3 Ensembl:ENSG00000185651 euGenes: HUgn7332
    ECgene: UBE2L3 Kegg: 7332 H-InvDB: UBE2L3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2L3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2L3 gene:
    Search GeneIP for patents involving UBE2L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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