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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2L3 Gene

protein-coding   GIFtS: 68
GCID: GC22P021903

ubiquitin-conjugating enzyme E2L 3
 Explore 19 diseases affiliated with
UBE2L3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UBE2L3    

Aliases
for UBE2L3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin-Conjugating Enzyme E2L 31 2     E2-F12
UBCH71 2 3 5     UbcM42
Ubiquitin Carrier Protein L32 3     Ubiquitin-Conjugating Enzyme E2 L32
Ubiquitin-Conjugating Enzyme E2-F12 3     Ubiquitin-Conjugating Enzyme UBCH72
Ubiquitin-Protein Ligase L32 3     UBCE73
L-UBC2 3     UbcH73
EC 6.3.2.193 8     

External Ids:    HGNC: 124881   Entrez Gene: 73322   Ensembl: ENSG000001856517   OMIM: 6037215   UniProtKB: P680363   
ORGUL members:         
NONCODE:n408250 n408251    

Export aliases for UBE2L3 gene to outside databases

Previous GC identifers: GC22P018620 GC22P020246 GC22P004880


Summaries
for UBE2L3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UBE2L3:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes
(E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2
ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos,
and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this
gene. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
Function: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein
ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic
E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and
ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its
covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the
selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in
progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in
myelopoiesis

Gene Wiki entry for UBE2L3


Genomic Views
for UBE2L3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.1  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2L3 gene promoter:
         p53   p300   NCX/Ncx   Brachyury   AP-4   Egr-4   CRE-BP1   COMP1   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBE2L3 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2L3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2L3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.2

UBE2L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2L3 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021903:  view genomic region     (about GC identifiers)

Start:
 21,903,736 bp from pter      End:
 21,978,323 bp from pter
Size:
 74,588 bases      Orientation:
 plus strand
ORGUL member locations:
Legend (see complete legend)

  • n408251
  • n408250
21921956 21950140 21978323 chr22

Proteins
for UBE2L3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 L3  
Size: 154 amino acids; 17862 Da
Subunit: Interacts with PARK2; involved in ubiquitination and degradation of misfolded proteins. Interacts with UBE3A;
used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL, ZAP70, RNF19A,
RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with NCOA1; they
functionally interact to regulate progesterone receptor transcriptional activity. May interact with NR3C1
Subcellular location: Nucleus. Cytoplasm
Caution: PubMed:10760570 reported that UBE2L1, UBE2L2 and UBE2L4 are most likely pseudogenes and the only expressed
member of this subfamily seems to be UBE2L3
4 PDB 3D structures from and Proteopedia for UBE2L3:
1C4Z (3D)        1FBV (3D)        3SQV (3D)        3SY2 (3D)    
Secondary accessions: B2R4A7 B4DDG1 P51966 P70653 Q9HAV1
Alternative splicing: 2 isoforms:  P68036-1   P68036-2   

Explore the universe of human proteins at neXtProt for UBE2L3: NX_P68036

Post-translational modifications:

  • Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to
    • ubiquitin-dependent proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P68036

    • 4 DME Specific Peptides for UBE2L3 (P68036)
     YPFKPPK  KNAEEFT  TKIYHPN  KGAFRIEINFP 

    UBE2L3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001243284.1  NP_001243285.1  NP_003338.1  

    ENSEMBL proteins: 
     ENSP00000344259   ENSP00000400906   ENSP00000445931  
    Reactome Protein details: P68036
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UBE2L3 (UbcH7)
    Enzo Life Sciences proteins for UBE2L3
    OriGene Purified Protein: UBE2L3
    OriGene Protein Over-expression Lysate: UBE2L3
    OriGene Custom Protein Services for UBE2L3 
    GenScript Custom Purified and Recombinant Proteins Services for UBE2L3
    Novus Biologicals UBE2L3 Protein
    Novus Biologicals UBE2L3 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for UBE2L3
    Uscn Proteins for UBE2L3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS8563171
    GO:0005634nucleus IDA11278816
    GO:0005737cytoplasm IDA9990509


    UBE2L3 for ontologies           About GeneDecksing



    UBE2L3 Antibody Products: 
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    Uscn ELISAs and CLIAs for UBE2L3

    Protein Domains /
    Families
    for UBE2L3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UBE2L3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P68036

    ProtoNet protein and cluster: P68036

    1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Domain: In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are absent: Pro
    and a His residues are present instead of an Asp and an Asp residues in positions 88 and 119,respectively
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Function
    for UBE2L3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Function: Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein
    ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic
    E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and
    ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its
    covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the
    selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in
    progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in
    myelopoiesis
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2L3:
    ubiquitin conjugating enzyme UBE2L3,homologous to L-UBC (UBE2L1)

    Enzyme Number (IUBMB): EC 6.3.2.191 2

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2L3
    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2L3 (see all 58):
    hsa-miR-21* hsa-miR-607 hsa-miR-488 hsa-miR-3653 hsa-miR-766 hsa-miR-500a hsa-miR-342-3p hsa-miR-409-5p
    SwitchGear 3'UTR luciferase reporter plasmid: UBE2L3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2L3 (see all 7)
    OriGene shRNA RFP: UBE2L3
    OriGene siRNA: UBE2L3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2L3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UBE2L3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2L3 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for UBE2L3

    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IDA15367689
    GO:0004842ubiquitin-protein ligase activity TAS8576257
    GO:0005515protein binding IPI9990509
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----


    UBE2L3 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for UBE2L3:
     Increased cell death HMECs cel  Increased number of cells in m  Upregulation of NF-kappaB path 

    Animal Models:
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ube2l3):
     cardiovascular system  embryogenesis  growth/size  mortality/aging 

    UBE2L3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UBE2L3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    		Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway1.00
    		Parkin-Ubiquitin Proteasomal System pathway0.93
    		Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    3Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    4Proteolysis Putative ubiquitin pathway
    		Proteolysis Putative ubiquitin pathway1.00
    		Proteolysis_Putative ubiquitin pathway0.97
    5Protein Stability
    		Protein Stability1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for UBE2L3
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2L3
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions
    Parkinson's Disease Pathway

    1 Cell Signaling Technology (CST) Pathway for UBE2L3
        Protein Stability

    2 GeneGo (Thomson Reuters) Pathways for UBE2L3
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Putative ubiquitin pathway

    4 BioSystems Pathways for UBE2L3 
        Parkinsons Disease Pathway
    Parkin-Ubiquitin Proteasomal System pathway
    Alpha-synuclein signaling
    BARD1 signaling events

    5        Reactome Pathways for UBE2L3
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    2         Kegg Pathways  (Kegg details for UBE2L3):
        Ubiquitin mediated proteolysis
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Pathway: Protein modification; protein ubiquitination


    UBE2L3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2L3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/76 Interacting proteins for UBE2L3 (P680361, 2, 3 ENSP000003442594) via UniProtKB, MINT, STRING, and/or I2D (see all 76)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARIH2O953761, 2, 3, ENSP000003487694EBI-711173,EBI-711158 MINT-63295 I2D: score=12 STRING: ENSP00000348769
    PARK2O602602, 3, ENSP000003558654MINT-8214139 I2D: score=4 STRING: ENSP00000355865
    RNF19BQ6ZMZ01, 3, ENSP000003625554EBI-711173,EBI-2466594 I2D: score=2 STRING: ENSP00000362555
    MAPK6Q166592, 3MINT-8262143 I2D: score=2 
    CBLP226812, 3, ENSP000002640334MINT-25109 I2D: score=4 STRING: ENSP00000264033
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA10888878
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IMP15367689
    GO:0006464cellular protein modification process TAS8576257
    GO:0006511ubiquitin-dependent protein catabolic process TAS8672131


    UBE2L3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UBE2L3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBE2L3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UBE2L3

    4 HMDB Compounds for UBE2L3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    2 Novoseek chemical compound relationships for UBE2L3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mg 132 61.5 4 17003263 (1)
    cysteine 1.38 3 9990509 (1), 10501966 (1)

    Search CenterWatch for drugs/clinical trials and news about UBE2L3 / UB2L3 

    Transcripts
    for UBE2L3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UBE2L3 gene (4 alternative transcripts): 
    NM_001256355.1  NM_001256356.1  NM_003347.3  NM_198157.1  

    Unigene Cluster for UBE2L3:

    Ubiquitin-conjugating enzyme E2L 3
    Hs.108104  [show with all ESTs]
    Unigene Representative Sequence: AK125396
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000342192(uc002zuz.1 uc002zva.1 uc011aig.2) ENST00000496722
    ENST00000458578 ENST00000545681

    miRNA
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    hsa-miR-21* hsa-miR-607 hsa-miR-488 hsa-miR-3653 hsa-miR-766 hsa-miR-500a hsa-miR-342-3p hsa-miR-409-5p
    SwitchGear 3'UTR luciferase reporter plasmid: UBE2L3 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2L3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2L3

    Additional cDNA sequence: 

    AJ000519.1 AK125396.1 AK291083.1 AK293179.1 AK299985.1 AK311761.1 BC053368.1 CR456606.1 
    NR_028436.2 NR_046082.1 S81003.1 X92962.1 

    24/49 DOTS entries (see all 49):

    DT.449914  DT.97768456  DT.100849248  DT.100849294  DT.120650536  DT.95306224  DT.120650589  DT.100687448 
    DT.92461107  DT.100870772  DT.120786431  DT.100862801  DT.95306212  DT.120786832  DT.95306214  DT.100687447 
    DT.100687442  DT.100851801  DT.100859956  DT.100856729  DT.95306272  DT.100643363  DT.100694529  DT.100850109 

    24/986 AceView cDNA sequences (see all 986):

    AI700261 CR626405 BQ215482 AA805464 BE618053 T31118 AI368098 T31410 
    AI141478 BX462159 BU196105 CB321953 AV654803 CB306116 BM785767 AU280766 
    AI300017 AA854829 BG334491 BU543268 BI908761 BQ723433 BQ423112 CR607714 

    GeneLoc Exon Structure


    Expression
    for UBE2L3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2L3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCTTCAGGGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See UBE2L3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2L3

    SOURCE GeneReport for Unigene cluster: Hs.108104

    UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
    Tissue specificity: Ubiquitous, with highest expression in testis

        SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2L3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for UBE2L3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2L3 gene from 7/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UBE2L31 ubiquitin-conjugating enzyme E2L 3 94.81(n)
    100(a)    		   416769  NM_001006180.1  NP_001006180.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UBE2L36
    --
    		 --
    		 96(a)
    64(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343282.1(1138838-1141850)
    1(91716499-91720951)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BM262438.12   -- 86.8(n)    BM262438.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.274102 Danio rerio similar to ubiquitin-conjugating enzyme more 85.24(n)    BC056724.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta UbcD103 ubiquitin cycle ubiquitin conjugating enzyme 74(a)
    (best of 3)    		   54E9   --
    worm
    (Caenorhabditis elegans)    		 Secernentea ubc-183   -- 59(a)   III(7139506-7140546)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UBC316
    		 ubiquitin-conjugating enzyme E2 D/E
    		 34(a)
    		 1 → many
    		 1(13683663-13684952)


    ENSEMBL Gene Tree for UBE2L3 (if available)
    TreeFam Gene Tree for UBE2L3 (if available) 

    Paralogs
    for UBE2L3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2L3 gene
    UBE2E32  UBE2D32  ENSG000002586772  UBE2L62  UBE2D12  UBE2D42  UBE2E22  UBE2D22  
    UBE2E12  UBE2W2  
    18/23 SIMAP similar genes for UBE2L3 using alignment to 2 protein entries:     UB2L3_HUMAN (see all proteins) (see all similar genes):
    UBE2L6    UBE2D4    UBE2D1    UBE2D2    UBE2D3    HR6A
    UBE2N    UBE2E3    UBE2A    UBE2E2    UBE2T    UBE2H
    UBE2E1    UBE2B    UBE2NL    UBE2G2    UBE2K    UBE2G1

    UBE2L3 for paralogs           About GeneDecksing


    5/6 Pseudogenes.org Pseudogenes for UBE2L3 (see all 6)
    PGOHUM00000239368 PGOHUM00000239451 PGOHUM00000248233 PGOHUM00000234491 PGOHUM00000245927


    Genomic Variants
    for UBE2L3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1195 NCBI SNPs in UBE2L3 are shown (see all 1195)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 22 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs8617871,2
    		--4877975(-) gacagA/Ggtttt 3 -- us2k10--------
    rs1136920451,2
    		C,--4878426(+) AGTGCG/AGTGGC 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs96097621,2
    		A--4878583(+) tcaggC/Gtggtc 4 -- us2k10--------
    rs1115041111,2
    		C,F,--4878818(+) TTCTAC/TAAAAA 4 -- us2k11Minor allele frequency- T:0.08NA 120
    rs1139291491,2
    		--4879281(+) GACAGG/TAGCCT 4 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1112341861,2
    		C,--4879710(+) GCGCCC/TGCCAC 4 -- us2k11Minor allele frequency- T:0.50WA 2
    rs21948271,2
    		--4879752(+) gagacC/Tgagtt 4 -- us2k10--------
    rs72908731,2
    		C,--4879982(+) GCGTTC/TCTCCA 4 -- ut51 nc-transcript-variantus2k12Minor allele frequency- T:0.08CSA WA 120
    rs110896201,2
    		C,F,A,H,--4880565(+) GAGCCC/GGCGCC 4 -- int1 nc-transcript-variant1Minor allele frequency- G:0.32EA 120
    rs734004151,2
    		C,--4880714(+) TGGGTC/AGTTTG 4 -- int1 nc-transcript-variant1Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for UBE2L3 (21903736 - 21978323 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for UBE2L3
         1 CNV: 5173

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    Disorders / Diseases
    for UBE2L3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UBE2L3 for disorders           About GeneDecksing

    OMIM gene information: 603721    OMIM disorders: --

    19 diseases for UBE2L3:    About MalaCards
    mantle cell lymphoma    systemic lupus erythematosus    lupus erythematosus    fanconi's anemia
    cockayne syndrome    cblc    celiac disease    alzheimer's disease
    gigantism    rheumatoid arthritis    crohn's disease    hepatitis b
    parkinson's disease    anemia    hepatocellular carcinoma    arthritis
    pharyngitis    hepatitis    carcinoma

    2 Novoseek disease relationships for UBE2L3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    papilloma 41.9 2 8563171 (1), 10760570 (1)
    alzheimers disease 0 1 8563171 (1)

    Human Genome Epidemiology (HuGE) Navigator: UBE2L3 (5 documents)

    Export disorders for UBE2L3 gene to outside databases

    Publications
    for UBE2L3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2L3 gene, integrated from 9 sources (see all 176):
    (articles sorted by number of sources associating them with UBE2L3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3. (PubMed id 9693040)1, 2, 3, 9 Moynihan T.P....Robinson P.A. (1998)
    2. Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7. (PubMed id 10760570)1, 2, 9 Ardley H.C.... Robinson P.A. (2000)
    3. UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation. (PubMed id 17003263)1, 2, 9 Garside H....Ray D. (2006)
    4. Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. (PubMed id 18946090)1, 2, 9 Whitcomb E.A....Taylor A. (2009)
    5. The ubiquitin ligase Triad1 inhibits myelopoiesis thr ough UbcH7 and Ubc13 interacting domains. (PubMed id 19340006)1, 2, 9 Marteijn J.A....van der Reijden B.A. (2009)
    6. Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. (PubMed id 8672131)1, 3, 9 Moynihan T.P....Robinson P.A. (1996)
    7. A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. (PubMed id 8563171)1, 2, 9 Robinson P.A.... Markham A.F. (1995)
    8. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. (PubMed id 11278816)1, 2, 9 Ardley H.C.... Robinson P.A. (2001)
    9. The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors. (PubMed id 15367689)1, 2, 9 Verma S....Nawaz Z. (2004)
    10. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PubMed id 11237715)1, 2, 9 Niwa J.... Sobue G. (2001)

    External Searches for UBE2L3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UBE2L3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7332 HGNC: 12488 AceView: UBE2L3 Ensembl:ENSG00000185651 euGenes: HUgn7332
    ECgene: UBE2L3 Kegg: 7332 H-InvDB: UBE2L3

    Other Databases showing UBE2L3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UBE2L3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2L3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UBE2L3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UBE2L3 gene:
    Search GeneIP for patents involving UBE2L3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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