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Aliases for UBE2L3 Gene

Aliases for UBE2L3 Gene

  • Ubiquitin Conjugating Enzyme E2 L3 2 3
  • Ubiquitin-Conjugating Enzyme E2L 3 2 3
  • Ubiquitin-Conjugating Enzyme E2-F1 3 4
  • Ubiquitin Conjugating Enzyme E2L 3 3 5
  • E2 Ubiquitin-Conjugating Enzyme L3 3 4
  • Ubiquitin Carrier Protein L3 3 4
  • Ubiquitin-Protein Ligase L3 3 4
  • L-UBC 3 4
  • UBCH7 3 4
  • Ubiquitin-Conjugating Enzyme UBCH7 3
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • E2-F1 3
  • UbcM4 3
  • UBCE7 4

External Ids for UBE2L3 Gene

Previous GeneCards Identifiers for UBE2L3 Gene

  • GC22P018620
  • GC22P020246
  • GC22P021903
  • GC22P004880

Summaries for UBE2L3 Gene

Entrez Gene Summary for UBE2L3 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for UBE2L3 Gene

UBE2L3 (Ubiquitin Conjugating Enzyme E2 L3) is a Protein Coding gene. Diseases associated with UBE2L3 include papilloma and keloid formation. Among its related pathways are Immune System and Remodeling of Adherens Junctions. GO annotations related to this gene include poly(A) RNA binding and ligase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2L3 Gene

  • Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.

Gene Wiki entry for UBE2L3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2L3 Gene

Genomics for UBE2L3 Gene

Regulatory Elements for UBE2L3 Gene

Promoters for UBE2L3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2L3 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2L3 Gene

Chromosome:
22
Start:
21,549,447 bp from pter
End:
21,624,034 bp from pter
Size:
74,588 bases
Orientation:
Plus strand

Genomic View for UBE2L3 Gene

Genes around UBE2L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2L3 Gene

Proteins for UBE2L3 Gene

  • Protein details for UBE2L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P68036-UB2L3_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 L3
    Protein Accession:
    P68036
    Secondary Accessions:
    • B2R4A7
    • B4DDG1
    • B4DSZ4
    • E7EWS7
    • P51966
    • P70653
    • Q9HAV1

    Protein attributes for UBE2L3 Gene

    Size:
    154 amino acids
    Molecular mass:
    17862 Da
    Quaternary structure:
    • Interacts with PARK2; involved in ubiquitination and degradation of misfolded proteins. Interacts with UBE3A; used by the papilloma virus HPV-16 E6 protein to ubiquitinate p53/TP53. Interacts with CCNB1IP1, CBL, ZAP70, RNF19A, RNF19B and RNF144B. Interacts with ARIH1. Interacts with ARIH2 (via RING-type 1). Interacts with NCOA1; they functionally interact to regulate progesterone receptor transcriptional activity. May interact with NR3C1.

    Three dimensional structures from OCA and Proteopedia for UBE2L3 Gene

    Alternative splice isoforms for UBE2L3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2L3 Gene

Proteomics data for UBE2L3 Gene at MOPED

Selected DME Specific Peptides for UBE2L3 Gene

Post-translational modifications for UBE2L3 Gene

  • Ubiquitinated. The alteration of UBE2L3 protein levels during the S-phase of the cell cycle is due to ubiquitin-dependent proteasomal degradation.
  • Ubiquitination at Lys 9, Lys 20, Lys 64, Lys 67, Lys 73, Lys 82, Lys 100, and Lys 131
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2L3 Gene

Antibody Products

  • R&D Systems Antibodies for UBE2L3 (UbcH7/UBE2L3)
  • Cell Signaling Technology (CST) Antibodies for UBE2L3 (UBE2L3)

Domains & Families for UBE2L3 Gene

Gene Families for UBE2L3 Gene

Protein Domains for UBE2L3 Gene

Suggested Antigen Peptide Sequences for UBE2L3 Gene

Graphical View of Domain Structure for InterPro Entry

P68036

UniProtKB/Swiss-Prot:

UB2L3_HUMAN :
  • In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are absent: Pro and a His residues are present instead of an Asp and an Asp residues in positions 88 and 119, respectively.
  • Belongs to the ubiquitin-conjugating enzyme family.
Domain:
  • In contrast to other ubiquitin-conjugating enzymes E2, residues essential for lysine reactivity are absent: Pro and a His residues are present instead of an Asp and an Asp residues in positions 88 and 119, respectively.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2L3: view

Function for UBE2L3 Gene

Molecular function for UBE2L3 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme UBE2L3,homologous to L-UBC (UBE2L1)
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PARK2 and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis.

Enzyme Numbers (IUBMB) for UBE2L3 Gene

Gene Ontology (GO) - Molecular Function for UBE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 15367689
GO:0004842 ubiquitin-protein transferase activity TAS 8563171
genes like me logo Genes that share ontologies with UBE2L3: view
genes like me logo Genes that share phenotypes with UBE2L3: view

Animal Model Products

miRNA for UBE2L3 Gene

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2L3 Gene

Localization for UBE2L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2L3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2L3 Gene COMPARTMENTS Subcellular localization image for UBE2L3 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 3
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for UBE2L3 Gene

Pathways & Interactions for UBE2L3 Gene

genes like me logo Genes that share pathways with UBE2L3: view

UniProtKB/Swiss-Prot P68036-UB2L3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006464 cellular protein modification process TAS 8576257
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8563171
GO:0008283 cell proliferation IMP 18946090
GO:0016567 protein ubiquitination IDA 9990509
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with UBE2L3: view

No data available for SIGNOR curated interactions for UBE2L3 Gene

Drugs & Compounds for UBE2L3 Gene

(4) Drugs for UBE2L3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(2) Additional Compounds for UBE2L3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2L3: view

Transcripts for UBE2L3 Gene

Unigene Clusters for UBE2L3 Gene

Ubiquitin-conjugating enzyme E2L 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2L3 Gene

No ASD Table

Relevant External Links for UBE2L3 Gene

GeneLoc Exon Structure for
UBE2L3
ECgene alternative splicing isoforms for
UBE2L3

Expression for UBE2L3 Gene

mRNA expression in normal human tissues for UBE2L3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2L3 Gene

This gene is overexpressed in Amniocyte (6.7) and Lavage (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBE2L3 Gene



SOURCE GeneReport for Unigene cluster for UBE2L3 Gene Hs.108104

mRNA Expression by UniProt/SwissProt for UBE2L3 Gene

P68036-UB2L3_HUMAN
Tissue specificity: Ubiquitous, with highest expression in testis.
genes like me logo Genes that share expression patterns with UBE2L3: view

Protein tissue co-expression partners for UBE2L3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE2L3 Gene

Orthologs for UBE2L3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2L3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2L3 35
  • 94.81 (n)
  • 100 (a)
UBE2L3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2L3 35
  • 97.4 (n)
  • 100 (a)
UBE2L3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2l3 35
  • 96.54 (n)
  • 100 (a)
Ube2l3 16
Ube2l3 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC452921 35
  • 98.92 (n)
  • 99.35 (a)
-- 36
  • 95 (a)
OneToMany
-- 36
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia UBE2L3 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2L3 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2L3 35
  • 94.81 (n)
  • 100 (a)
UBE2L3 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2L3 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2l3 35
  • 85.5 (n)
  • 97.4 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.27410 35
ube2l3b 35
  • 81.39 (n)
  • 90.91 (a)
ube2l3a 36
  • 85 (a)
OneToMany
ube2l3b 36
  • 77 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3483 35
fruit fly
(Drosophila melanogaster)
Insecta CG17030 37
  • 48 (a)
Ubc84D 37
  • 63 (a)
UbcD10 37
  • 74 (a)
UbcD10 36
  • 71 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-18 37
  • 59 (a)
ubc-18 36
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 36
  • 39 (a)
ManyToMany
UBC5 36
  • 37 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
CSA.5148 36
  • 37 (a)
ManyToMany
Species with no ortholog for UBE2L3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2L3 Gene

ENSEMBL:
Gene Tree for UBE2L3 (if available)
TreeFam:
Gene Tree for UBE2L3 (if available)

Paralogs for UBE2L3 Gene

(23) SIMAP similar genes for UBE2L3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBE2L3: view

Variants for UBE2L3 Gene

Sequence variations from dbSNP and Humsavar for UBE2L3 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs131644 -- 21,558,267(-) GGAAG(A/C)TTAAA intron-variant
rs131645 -- 21,558,649(+) aaaaa(-/A)CACTT intron-variant
rs131646 -- 21,558,670(+) ttttt(-/T)gtaga intron-variant
rs131648 -- 21,559,917(-) AGCAC(A/G)GTCCC intron-variant
rs131650 -- 21,560,614(+) CCTGG(C/G)TAGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2L3 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv428386 CNV Loss 18775914
nsv511071 OTHER Inversion 20534489
nsv914458 CNV Loss 21882294
nsv834145 CNV Loss 17160897
dgv4881n71 CNV Loss 21882294

Variation tolerance for UBE2L3 Gene

Residual Variation Intolerance Score: 57.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2L3 Gene

HapMap Linkage Disequilibrium report
UBE2L3
Human Gene Mutation Database (HGMD)
UBE2L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2L3 Gene

Disorders for UBE2L3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for UBE2L3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
papilloma
  • papillomatosis
keloid formation
diffuse cutaneous systemic sclerosis
  • diffuse scleroderma
angelman syndrome
  • as
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UBE2L3

Genetic Association Database (GAD)
UBE2L3
Human Genome Epidemiology (HuGE) Navigator
UBE2L3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2L3
genes like me logo Genes that share disorders with UBE2L3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2L3 Gene

Publications for UBE2L3 Gene

  1. Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3. (PMID: 9693040) Moynihan T.P. … Robinson P.A. (Genomics 1998) 2 3 4 23 67
  2. Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. (PMID: 8672131) Moynihan T.P. … Robinson P.A. (Mamm. Genome 1996) 2 3 23
  3. Kinetics of the transfer of ubiquitin from UbcH7 to E6AP. (PMID: 20039703) Purbeck C. … Kuhlman B. (Biochemistry 2010) 3 23
  4. Identification and characterization of a novel endogenous murine parkin mutation. (PMID: 20089136) Ramsey C.P. … Giasson B.I. (J. Neurochem. 2010) 3 23
  5. Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7. (PMID: 18946090) Whitcomb E.A. … Taylor A. (Mol. Biol. Cell 2009) 3 23

Products for UBE2L3 Gene

Sources for UBE2L3 Gene

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