V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

UBE2L3 Gene

protein-coding GIFtS: 62

GC22P020246

ubiquitin-conjugating enzyme E2L 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E2-F1 ^², ³
EC 6.3.2.19 ^³
L-UBC ^², ³
UBCE7 ^³
UBCH7 ^¹, ², ³, ⁵
UbcH7 ^³
UbcM4 ^²

Descriptions
Ubiquitin carrier protein L3 ^³
Ubiquitin-protein ligase L3 ^³
ubiquitin carrier protein ^²
ubiquitin-conjugating enzyme E2L 3 ^²
ubiquitin-conjugating enzyme UBCH7 ^²
ubiquitin-protein ligase ^²

External Ids
HGNC: 12488¹
Entrez Gene: 7332²
UniProtKB: P68036³
Ensembl: ENSG00000185651⁷

Search outside databases for aliases for UBE2L3 gene

Previous GC identifer: GC22P018620

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2L3:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and

ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme

family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the

NF-kB precursor p105 in vitro. Two alternatively spliced transcript variants encoding distinct

isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination

of p53/TP53

Gene Wiki entry for UBE2L3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2L3 gene

Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.2

UBE2L3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P020246: (about GC identifiers)

Start:	20,251,957 bp from pter
End:	20,308,323 bp from pter
Size:	56,367 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000022.9 NT_011520.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 L3

Size: 154 amino acids; 17862 Da

Subunit: Binds UBE3A, HEI10, CBL, ZAP70, RNF19A, RNF19B and RNF144B

Caution: PubMed:10760570 reported that UBE2L1, UBE2L2 and UBE2L4 are most likely pseudogenes and

the only expressed member of this subfamily seems to be UBE2L3

PDB structure from and Proteopedia :

1C4Z (3D)

1FBV (3D)

Secondary accessions: P51966 P70653 Q9HAV1

REFSEQ proteins (2 alternative transcripts):

NP_003338.1 NP_937800.1

ENSEMBL proteins:

ENSP00000344259

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for UBE2L3
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2L3
	Recombinant Proteins from Abcam (Ube2L3)
	Human Recombinant Proteins from Abnova (UBE2L3)

OriGene Purified Recombinant Human Protein: UBE2L3

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000151	ubiquitin ligase complex	TAS	8563171
GO:0005737	cytoplasm	IDA	9990509

About this table

Antibodies for UBE2L3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE2L3
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for UBE2L3
	Antibodies from Abcam (Ube2L3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2L3)
	Novus Biologicals Antibodies for UBE2L3

Assays for UBE2L3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2L3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P68036

ProtoNet protein and cluster: P68036

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2L3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2L3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003347

Applied Biosystems Silencer® siRNAs for UBE2L3

Sigma-Aldrich siRNA and siRNA Panels for UBE2L3

Sigma-Aldrich shRNA Panels and shRNA for UBE2L3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2L3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003347
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003347
untagged cDNA clones in CMV expression vector (see all 2): NM_003347

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003347

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination

of p53/TP53

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19

Genatlas biochemistry entry for UBE2L3:

ubiquitin conjugating enzyme UBE2L3,homologous to L-UBC (UBE2L1)

3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ube2l3):

embryogenesis

growth/size

lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	8563171 8576257
GO:0016874	ligase activity	IEA	--
GO:0019899	enzyme binding	TAS	8563171

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2L3 (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway
Hypoxia Signaling in the Cardiovascular System

GeneDecks UBE2L3 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2L3

5/61 Interacting proteins for UBE2L3 (P68036^{1, 2} ENSP00000344259³) via UniProtKB, MINT, and/or STRING (see all 61 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBL	P22681², ENSP00000264033³	MINT-25109 STRING (score=.999)
AURKA	O14965¹	EBI-711173, EBI-448680
ARIH2	O95376²	MINT-63295
ARIH1	ENSP00000369217³	STRING (score=.999)
UBE3A	ENSP00000232165³	STRING (score=.999)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	8563171 8672131
GO:0016567	protein ubiquitination	IDA	9990509
GO:0051246	regulation of protein metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2L3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2L3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2L3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003347

Sigma-Aldrich siRNA and siRNA Panels for UBE2L3

Sigma-Aldrich shRNA Panels and shRNA for UBE2L3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003347 NM_198157

REFSEQ mRNAs for UBE2L3 gene (2 alternative transcripts):

NM_003347.2 NM_198157.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003347 NM_198157

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003347
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003347
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003347

Additional cDNA sequence:

AJ000519.1 AK125396.1 AK291083.1 AK293179.1 AK299985.1 AK311761.1 BC053368.1 CR456606.1

CR591815.1 CR593455.1 CR594871.1 CR597825.1 CR602038.1 CR602465.1 CR604504.1 CR607527.1

CR607714.1 CR607739.1 CR608960.1 CR609123.1 CR609763.1 CR610403.1 CR611646.1 CR611871.1

CR612269.1 CR615420.1 CR616187.1 CR618384.1 CR625640.1 CR626405.1 S81003.1 X92962.1

24/43 DOTS entries (see all 43 ):

DT.449914 DT.97768456 DT.100849248 DT.100849294 DT.120650536 DT.120650589 DT.100687448 DT.100862801

DT.100870772 DT.120786431 DT.95306212 DT.120786832 DT.95306214 DT.100687447 DT.100687442 DT.100851801

DT.95306224 DT.95306272 DT.100643363 DT.100694529 DT.100856729 DT.92461107 DT.92461117 DT.85104849

24/986 AceView cDNA sequences (see all 986 ):

CR597825 W84311 CB156746 CR616187 AA297878 CA308387 BM672608 CB068460

BU950032 BG152422 AI375811 CB321953 AA297834 AI052814 T31118 BX400707

BU626764 BQ447151 BM807071 Z45714 BU196105 AA069750 AI368098 AU280766

highest scoring ESTs for UBE2L3:

AW006924 S81003 X92962 AA002094 AA026895 AA026896 AA029263 AA029301 AA034949 AA035297

Unigene Cluster for UBE2L3:

Ubiquitin-conjugating enzyme E2L 3

Hs.108104 [show with all ESTs]

Unigene Representative Sequence: AK125396

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000342192

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2L3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2L3

¹ / ² / ³

11 probe-sets matching UBE2L3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
64361_s_at²^{, 3}	U95-C	1	1.00	1.00	0.91	1.09	AW006924	1.00	1.00	1.00	1
38701_at²^{, 3}	U95-A	1	1.00	1.00	0.79	0.95	X92962	1.00	1.00	1.00	1
223_at²^{, 3}	U95-A	3	1.00	0.69	0.42	0.96	S81003	1.00	1.00	1.00	1
200684_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI819709	0.80	1.00	0.91	1
200676_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003347	0.60	1.00	0.82	1
200683_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	BE964689	0.80	1.00	0.91	1
200682_s_at²^{, 3}	U133-A	3	1.00	0.46	--	--	BG531983	0.80	1.00	0.91	1
200684_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200676_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200683_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
200682_s_at²	U133Plus2	3	1.00	0.46	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.108104
Expression variation in blood from EXPOLDB for UBE2L3
UniProtKB/Swiss-Prot: UB2L3_HUMAN, P68036
Tissue specificity: Ubiquitous, with highest expression in testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2L3 gene from 5/13 species (see all 13 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2L3¹	--	ubiquitin-conjugating enzyme E2L 3	97.4(n) 100(a)	477572 XM_534767.2 XP_534767.2
chimpanzee (Pan troglodytes)	UBE2L3¹	--	ubiquitin-conjugating enzyme E2L 3	98.92(n) 99.35(a)	452921 XM_509962.2 XP_509962.1
rat (Rattus norvegicus)	Ube2l3¹	--	ubiquitin-conjugating enzyme E2L 3	95.24(n) 100(a)	363836 XM_344046.3 XP_344047.2
mouse (Mus musculus)	Ube2l3^{1, 5}	16 (10.20 cM)⁵	ubiquitin-conjugating enzyme E2L 3^{1, 5}	96.54(n)¹ 100(a)¹	22195¹ NM_009456.2¹ NP_033482.1¹ AF071557⁵ AJ130961⁵ (see all 25)
chicken (Gallus gallus)	UBE2L3¹	--	ubiquitin-conjugating enzyme E2L 3	94.81(n) 100(a)	416769 NM_001006180.1 NP_001006180.1

About this table Species with no ortholog for UBE2L3

ENSEMBL Gene Tree for UBE2L3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2L3 gene

UBE2L6² UBE2S² UBE2I²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/320 NCBI SNPs in UBE2L3 are shown (see all 320 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 85)

AB	SNP ID	Valid	Chr 22 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs7444^1,2	A,C,F,H	20306934(+)	`TGCAGT/CGGCCC`	2	--	ut3¹		8		NA EA MN EU WA	848
--	rs131665^1,2	A,C,F,H	20250903(-)	`TTGACT/CCCATG`	2	--	ng5¹		4		EU EA WA	412
	rs13392^1,2	C,F,H	20307678(+)	`GCTGGC/TGTTTC`	2	--	ut3¹ ese³		8		MN EU EA WA NA	742
	rs7445^1,2	A,C,F	20307047(+)	`ACCCCC/TTCCTC`	2	--	ut3¹ ese³ trp³		5		EA NA MN	338
	rs364962^1,2	C,H	20306407(+)	`GAGAAG/AAGACT`	2	--	ut3¹ trp³		5		MN EU EA WA	604
--	rs140489^1,2	A,C	20251294(-)	`tttaaC/Tccttg`	2	--	ng5¹		0	--	--	--	--
--	rs5754407^1,2	C,H	20308299(+)	`TGCCCG/ATAATA`	2	--	ut3¹ ese³		5		EU EA WA	586
	rs9815^1,2	F,H	20307539(+)	`ATGGGC/TAGGTT`	2	--	ut3¹ ese³		5		MN EU EA WA	604
	rs16985160^1,2	F,H	20308447(+)	`CCAGCC/GTCTCC`	2	--	ng3¹		7		NA EU EA WA	562
--	rs140490^1,2	A,C	20251686(-)	`tcacgA/Cggtca`	2	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for UBE2L3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603721

2 Novoseek disease relationships for UBE2L3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
papilloma	45.12	2	8563171 (1), 10760570 (1)
alzheimers disease	0.00	1	8563171 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/59 PubMed articles for UBE2L3 gene (see all 59 ):

Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3. (PubMed id 9693040)^{1, 2, 3, 4} Moynihan T.P....Robinson P.A. (1998)
Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7. (PubMed id 10760570)^{1, 3, 4} Ardley H.C.... Robinson P.A. (2000)
Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3. (PubMed id 8672131)^{1, 2, 3} Moynihan T.P....Robinson P.A. (1996)
A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. (PubMed id 8563171)^{1, 3, 4} Robinson P.A.... Markham A.F. (1995)
A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. (PubMed id 11237715)^{1, 3, 4} Niwa J.... Sobue G. (2001)
Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. (PubMed id 10558980)^{1, 3, 4} Huang L.... Pavletich N.P. (1999)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)^{3, 4} Collins J.E.... Dunham I. (2004)
A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. (PubMed id 12612082)^{3, 4} Toby G.G.... Golemis E.A. (2003)
Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. (PubMed id 10966114)^{3, 4} Zheng N.... Pavletich N.P. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7332	HGNC: 12488	AceView: UBE2L3	Ensembl:ENSG00000185651	euGenes: HUgn7332
ECgene: UBE2L3	H-InvDB: UBE2L3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for UBE2L3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBE2L3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2L3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2L3		Antibodies for UBE2L3
	Explore super-pooled esiRNAs		Proteins for UBE2L3
	Lentivirus-delivered shRNAs for UBE2L3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBE2L3)
	Antibodies (UBE2L3)
	Chimera RNAi (UBE2L3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for UBE2L3

	Recombinant Proteins (Ube2L3)
	Antibodies (Ube2L3)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for UBE2L3

	Assays/Proteins for UBE2L3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for UBE2L3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
UBE2L3 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

UBE2L3 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for UBE2L3

Summaries
for UBE2L3

Genomic Location
for UBE2L3

Proteins
for UBE2L3

Protein Domains/
Families
for UBE2L3

Gene Function
for UBE2L3

Pathways & Interactions
for UBE2L3

Drugs & Compounds
for UBE2L3

Transcripts
for UBE2L3

Expression
for UBE2L3

Orthologs
for UBE2L3

Paralogs
for UBE2L3

SNPs/Variants
for UBE2L3

Disorders & Mutations
for UBE2L3

Medical News
for UBE2L3

Publications
for UBE2L3

Search for UBE2L3

Genome Databases showing UBE2L3

Other Databases showing UBE2L3

Specialized Databases showing UBE2L3

Licensable Technologies
for UBE2L3

Services
for UBE2L3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2L3 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor UBE2L3

Summariesfor UBE2L3

Genomic Locationfor UBE2L3

Proteinsfor UBE2L3

Protein Domains/Familiesfor UBE2L3

Gene Functionfor UBE2L3

Pathways & Interactionsfor UBE2L3

Drugs & Compoundsfor UBE2L3

Transcriptsfor UBE2L3

Expression for UBE2L3

Orthologsfor UBE2L3

Paralogsfor UBE2L3

SNPs/Variantsfor UBE2L3

Disorders & Mutationsfor UBE2L3

Medical Newsfor UBE2L3

Publicationsfor UBE2L3

Search for UBE2L3

Genome Databases showing UBE2L3

Other Databases showing UBE2L3

Specialized Databases showing UBE2L3

Licensable Technologiesfor UBE2L3

Servicesfor UBE2L3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2L3

Summaries
for UBE2L3

Genomic Location
for UBE2L3

Proteins
for UBE2L3

Protein Domains/
Families
for UBE2L3

Gene Function
for UBE2L3

Pathways & Interactions
for UBE2L3

Drugs & Compounds
for UBE2L3

Transcripts
for UBE2L3

Expression
for UBE2L3

Orthologs
for UBE2L3

Paralogs
for UBE2L3

SNPs/Variants
for UBE2L3

Disorders & Mutations
for UBE2L3

Medical News
for UBE2L3

Publications
for UBE2L3

Licensable Technologies
for UBE2L3

Services
for UBE2L3