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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2K Gene

protein-coding   GIFtS: 60
GCID: GC04P039700

Ubiquitin-Conjugating Enzyme E2K

(Previous names: huntingtin interacting protein 2, ubiquitin-conjugating...)
(Previous symbol: HIP2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2K1 2     Ubiquitin-Protein Ligase2 3
HIP21 2 3 5     HIP-22 3
Huntingtin Interacting Protein 21 2     LIG2 3
Ubiquitin-Conjugating Enzyme E2K (UBC1 Homolog, Yeast)1 2     EC 6.3.2.193 8
Huntingtin-Interacting Protein 22 3     E2(25K)2
Ubiquitin Carrier Protein2 3     E2-25K2
Ubiquitin-Conjugating Enzyme E2(25K)2 3     HYPG2
Ubiquitin-Conjugating Enzyme E2-25 KDa2 3     UBC12
Ubiquitin-Conjugating Enzyme E2-25K2 3     Ubiquitin-Conjugating Enzyme E2 K2

External Ids:    HGNC: 49141   Entrez Gene: 30932   Ensembl: ENSG000000781407   OMIM: 6028465   UniProtKB: P610863   

Export aliases for UBE2K gene to outside databases

Previous GC identifers: GC04P039377 GC04P039024


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2K Gene:
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with
RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known
functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the
suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I
heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants
encoding different isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2K Gene: 
UBE2K (ubiquitin-conjugating enzyme E2K) is a protein-coding gene. Diseases associated with UBE2K include pancoast tumor, and huntington's disease, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Innate Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and ubiquitin-ubiquitin ligase activity.

UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro,
in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of
'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated
substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the
endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May
mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination
and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of
NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved
in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol.
In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1

Gene Wiki entry for UBE2K (HIP2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016297.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2K gene promoter:
         Nkx3-1   ER-alpha   Nkx3-1 v4   AP-1   ATF-2   Nkx3-1 v1   Nkx3-1 v2   Nkx3-1 v3   IRF-7A   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2K promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2K

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2K


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14   Ensembl cytogenetic band:  4p14   HGNC cytogenetic band: 4p14

UBE2K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2K gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P039700:  view genomic region     (about GC identifiers)

Start:
39,699,664 bp from pter      End:
39,784,412 bp from pter
Size:
84,749 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 K  
Size: 200 amino acids; 22407 Da
Subunit: Interacts with RNF138/NARF. Interacts with BRCA1
Subcellular location: Cytoplasm (By similarity)
6 PDB 3D structures from and Proteopedia for UBE2K:
1YLA (3D)        2O25 (3D)        3E46 (3D)        3F92 (3D)        3K9O (3D)        3K9P (3D)    
Secondary accessions: A6NJC1 A8K5Y9 B2RDF8 C9JGP1 O54806 P27924 Q16721 Q9CVV9 Q9Y2D3
Alternative splicing: 3 isoforms:  P61086-1   P61086-2   P61086-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2K: NX_P61086

Explore proteomics data for UBE2K at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylation at Lys-14 impairs catalytic activity (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61086

  • 4/5 DME Specific Peptides for UBE2K (P61086) (see all 5)
     ICLDILK  GPPDTPY  RIKREFKEV  TLRTVLLSLQA 

    UBE2K Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2K Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001104582.1  NP_001104583.1  NP_005330.1  

    ENSEMBL proteins: 
     ENSP00000261427   ENSP00000425301   ENSP00000421203   ENSP00000390483   ENSP00000421422  
     ENSP00000295963  
    Reactome Protein details: P61086
    Human Recombinant Protein Products for UBE2K: 
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    Novus Biologicals UBE2K Proteins
    Novus Biologicals UBE2K Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UBE2K
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    UBE2K for ontologies           About GeneDecksing



    UBE2K Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    5/6 InterPro protein domains (see all 6):
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR000449 UBA/transl_elong_EF1B_N
     IPR023313 UBQ-conjugating_AS
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P61086

    ProtoNet protein and cluster: P61086

    UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086
    Similarity: Belongs to the ubiquitin-conjugating enzyme family
    Similarity: Contains 1 UBA domain


    UBE2K for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2K_HUMAN, P61086
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro,
    in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of
    'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated
    substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the
    endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May
    mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination
    and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of
    NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved
    in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol.
    In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
    Induction: By aggregated low-density lipoprotein

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0031625ubiquitin protein ligase binding IPI16714285
         
    UBE2K for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for UBE2K:
     Cell division defect  Increased 8N DNA content  Increased cell death HMECs cel  Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ube2k):
     cellular  nervous system 

    UBE2K for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2K 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2K 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2K 

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    SwitchGear 3'UTR luciferase reporter plasmidUBE2K 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2K


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2K About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.90
    Negative regulators of RIG-I/MDA5 signaling0.78
    Innate Immune System0.90
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.78
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    Adaptive Immune System0.56
    4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    Negative regulators of RIG-I/MDA5 signaling0.49
    5Protein Stability
    Protein Stability

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for UBE2K
        Neuroscience
    Protein Stability

    5/11        Reactome Pathways for UBE2K (see all 11)
        Negative regulators of RIG-I/MDA5 signaling
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Immune System
    Innate Immune System
    Adaptive Immune System


    1         Kegg Pathway  (Kegg details for UBE2K):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086
    Pathway: Protein modification; protein ubiquitination


    UBE2K for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2K

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/117 Interacting proteins for UBE2K (P610862, 3 ENSP000002614274) via UniProtKB, MINT, STRING, and/or I2D (see all 117)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIAS4Q8N2W92, 3, ENSP000002629714MINT-3980642 I2D: score=4 STRING: ENSP00000262971
    ITSN1Q158112, 3, ENSP000003707194MINT-8276207 I2D: score=2 STRING: ENSP00000370719
    PRPF40AO754002, 3MINT-8276218 I2D: score=2 
    ENSG00000224994Q9HCM93, ENSP000004119494I2D: score=1 STRING: ENSP00000411949
    ENSG00000232839Q9HCM93, ENSP000003983554I2D: score=1 STRING: ENSP00000398355
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS8702625
    GO:0032434regulation of proteasomal ubiquitin-dependent protein catabolic process IEA--
    GO:0070936protein K48-linked ubiquitination IDA--

    UBE2K for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBE2K for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2K

    6 Novoseek inferred chemical compound relationships for UBE2K gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 34.4 1 14517261 (1)
    cysteine 23.6 5 16342931 (3), 11504715 (1), 14517261 (1)
    actinomycin d 16.3 1 9685415 (1)
    atp 7 2 8034027 (1), 16275321 (1)
    tyrosine 0 1 10966114 (1)
    h2o2 0 3 12773310 (3)

    Search CenterWatch for drugs/clinical trials and news about UBE2K

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2K gene (3 alternative transcripts): 
    NM_001111112.1  NM_001111113.1  NM_005339.4  

    Unigene Cluster for UBE2K:

    Ubiquitin-conjugating enzyme E2K
    Hs.50308  [show with all ESTs]
    Unigene Representative Sequence: NM_005339
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261427(uc003guu.4 uc003gus.4 uc003gut.4 uc010ifn.3 uc011byq.2 uc003guq.4)
    ENST00000510934 ENST00000513231 ENST00000438068 ENST00000503368 ENST00000445950
    ENST00000510719 ENST00000295963
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AB022435.1 AB022436.1 AK093533.1 AK291454.1 AK295846.1 AK307130.1 AK315524.1 AL117568.1 
    BC022804.1 BC050600.1 BX641089.1 U58522.1 

    21 DOTS entries:

    DT.92442814  DT.453166  DT.97780192  DT.95364285  DT.100718402  DT.75154564  DT.95364286  DT.100777751 
    DT.100813999  DT.95364298  DT.100763089  DT.91812239  DT.91828453  DT.95364296  DT.102834685  DT.40111771 
    DT.75187719  DT.91742775  DT.92442816  DT.92442819  DT.92442822 

    24/407 AceView cDNA sequences (see all 407):

    AA633461 AI080393 BQ416785 BU689861 BU170325 BM479441 BQ016199 AW139164 
    AU134343 AA334137 BM561379 AV752976 BX427147 Z45197 AA970776 AA838816 
    BM839856 H23674 Z40924 BU508781 CA394416 AV705320 CA432372 BE504442 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2K (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
    SP1:                          -                                                         
    SP2:                    -     -                                                         
    SP3:                          -                                   -     -     -         
    SP4:                          -     -                                                   
    SP5:                          -     -     -                                             


    ECgene alternative splicing isoforms for UBE2K

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2K expression in normal human tissues (normalized intensities)      UBE2K embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGTAGAG
    UBE2K Expression
    About this image


    UBE2K expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/40 selected tissues (see all 40) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Thalamus
             brain/midbrain   
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Stem Bronchi
             lung ; pneumocytes   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See UBE2K Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2K

    SOURCE GeneReport for Unigene cluster: Hs.50308

    UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086
    Tissue specificity: Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small
    intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear
    cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in
    cerebellum and brainstem

        SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2K: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2K gene from 10/26 species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2k1 , 5 ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)5
    ubiquitin-conjugating enzyme E2K1
    95.67(n)1
    100(a)1
      5 (33.72 cM)5
    533231  NM_016786.31  NP_058066.21 
     655372335 
    chicken
    (Gallus gallus)
    Aves UBE2K1 ubiquitin-conjugating enzyme E2K 92.33(n)
    99.5(a)
      428787  NM_001031540.1  NP_001026711.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2K6
    Uncharacterized protein
    90(a)
    1 ↔ 1
    5(99793960-99812196)
    African clawed frog
    (Xenopus laevis)
    Amphibia hip2-prov2 huntingtin interacting protein 2 84.14(n)    BC041728.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2kb1 ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) 81.17(n)
    97(a)
      30100  NM_001008611.2  NP_001008611.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta UbcD41 Ubiquitin conjugating enzyme 4 62.98(n)
    68.34(a)
      39133  NM_079286.2  NP_524010.2 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-201 Protein UBC-20 56.28(n)
    52.26(a)
      175185  NM_064773.3  NP_497174.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC11 Ubc1p 52.03(n)
    43.92(a)
      851757   NP_010462.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC271 ubiquitin-conjugating enzyme E2 27 52.81(n)
    49.47(a)
      835159  NM_124465.5  NP_199900.1 
    rice
    (Oryza sativa)
    Liliopsida Os.186732 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 80.85(n)    AK073357.1 


    ENSEMBL Gene Tree for UBE2K (if available)
    TreeFam Gene Tree for UBE2K (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2K gene
    18/23 SIMAP similar genes for UBE2K using alignment to 5 protein entries:     UBE2K_HUMAN (see all proteins) (see all similar genes):
    HIP2    UBE2D3    UBE2D2    UBE2D1    UBE2D4    UBE2M
    UBE2H    UBE2A    UBE2B    UBE2NL    UBE2C    UBE2E3
    UBE2G1    UBE2S    UBE2E2    UBE2L3    UBE2T    UBE2N

    UBE2K for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBE2K
    PGOHUM00000245096


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1999 SNPs in UBE2K are shown (see all 1999)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126202981,2
    C--39023979(+) TGTGT-/GAG   
       AGAGA
    GAGAG
    3 -- us2k11Minor allele frequency- GAGAGAGA:0.00CSA 2
    rs572892681,2
    C--39079030(+) TTTTT-/T/TT  
            
    GAGAC
    3 -- int11NA 2
    rs1905462041,2
    --39697778(+) TGCCAC/TCACAA 3 -- us2k10--------
    rs1429450451,2
    --39697793(+) AATTAC/TTTTTG 3 -- us2k10--------
    rs76818671,2
    C,F,H--39697803(+) GGTAAG/AACCAT 3 -- us2k1 tfbs311Minor allele frequency- A:0.36NA WA CSA EA 376
    rs1510891021,2
    --39697995(+) ATTATC/GTTTAG 3 -- us2k10--------
    rs76571261,2
    C,F--39698107(+) ccaccG/Acgccc 3 -- us2k11Minor allele frequency- A:0.07NA 120
    rs762092651,2
    F--39698150(+) TTTTGG/TTTTTT 3 -- us2k11Minor allele frequency- T:0.50NA 4
    rs76586791,2
    C,F,A--39698171(+) agtctT/Cgctcc 3 -- us2k15Minor allele frequency- C:0.40NA CSA 10
    rs76575021,2
    C,F--39698302(+) gcccaG/Cctatt 3 -- us2k13Minor allele frequency- C:0.33NA WA 6

    HapMap Linkage Disequilibrium report for UBE2K (39699664 - 39784412 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for UBE2K (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2666876CNV Deletion23128226
    esv2669309CNV Deletion23128226
    esv2660659CNV Deletion23128226
    esv2727459CNV Deletion23290073
    nsv878948CNV Loss21882294
    nsv878954CNV Loss21882294
    dgv5528n71CNV Loss21882294
    nsv516320CNV Loss19592680
    nsv518644CNV Loss19592680
    nsv878949CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2K
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2K

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602846    OMIM disorders: --

    18 diseases for UBE2K:    About MalaCards
    pancoast tumor    huntington's disease    liddle syndrome    autistic disorder
    cblc    leptospirosis    breast cancer susceptibility    angelman syndrome
    fanconi's anemia    anemia    hepatitis c    parkinson's disease
    atherosclerosis    cerebritis    alzheimer's disease    breast cancer
    hepatitis    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for UBE2K:
    Angelman syndrome     Parkinson's disease

    UBE2K for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for UBE2K gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    huntington disease 28.5 2 10585161 (1)


    Export disorders for UBE2K gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2K gene, integrated from 9 sources (see all 146):
    (articles sorted by number of sources associating them with UBE2K)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PubMed id 17873885)1, 2, 3, 9 Christensen D.E....Klevit R.E. (2007)
    2. Huntingtin is ubiquitinated and interacts with a specific ubiquitin- conjugating enzyme. (PubMed id 8702625)1, 2, 3 Kalchman M.A.... Hayden M.R. (1996)
    3. Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. (PubMed id 10634809)1, 2, 9 Kikuchi J.... Sakurabayashi I. (2000)
    4. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PubMed id 16868077)1, 2, 9 Flierman D.... Chau V. (2006)
    5. NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PubMed id 16714285)1, 2 Yamada M.... Shibuya H. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    9. Regulation of macrophage-specific gene expression by degenerated lipoproteins. (PubMed id 10675012)1, 2 Furukawa Y....Sakurabayashi I. (2000)
    10. E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. (PubMed id 11513855)1, 9 Lee S.-J.... Kang S. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3093 HGNC: 4914 AceView: HIP2 Ensembl:ENSG00000078140 euGenes: HUgn3093
    ECgene: UBE2K Kegg: 3093 H-InvDB: UBE2K

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2K Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2K gene:
    Search GeneIP for patents involving UBE2K

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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