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Aliases for UBE2K Gene

Aliases for UBE2K Gene

  • Ubiquitin-Conjugating Enzyme E2K 2 3
  • HIP2 3 4 6
  • Ubiquitin-Conjugating Enzyme E2K (UBC1 Homolog, Yeast) 2 3
  • Ubiquitin-Conjugating Enzyme E2(25K) 3 4
  • Ubiquitin-Conjugating Enzyme E2-25K 3 4
  • Huntingtin Interacting Protein 2 2 3
  • Huntingtin-Interacting Protein 2 3 4
  • Ubiquitin Carrier Protein 3 4
  • Ubiquitin-Protein Ligase 3 4
  • EC 6.3.2.19 4 63
  • HIP-2 3 4
  • LIG 3 4
  • Ubiquitin-Conjugating Enzyme E2-25 KDA 3
  • Ubiquitin-Conjugating Enzyme E2-25 KDa 4
  • Ubiquitin-Conjugating Enzyme E2 K 3
  • E2(25K) 3
  • E2-25K 3
  • HYPG 3
  • UBC1 3

External Ids for UBE2K Gene

Previous HGNC Symbols for UBE2K Gene

  • HIP2

Previous GeneCards Identifiers for UBE2K Gene

  • GC04P039377
  • GC04P039024

Summaries for UBE2K Gene

Entrez Gene Summary for UBE2K Gene

  • The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2K Gene

UBE2K (Ubiquitin-Conjugating Enzyme E2K) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Protein Stability. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-ubiquitin ligase activity.

UniProtKB/Swiss-Prot for UBE2K Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of Lys-48-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

Gene Wiki entry for UBE2K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2K Gene

Genomics for UBE2K Gene

Regulatory Elements for UBE2K Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2K Gene

Start:
39,698,044 bp from pter
End:
39,782,792 bp from pter
Size:
84,749 bases
Orientation:
Plus strand

Genomic View for UBE2K Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2K Gene

Proteins for UBE2K Gene

  • Protein details for UBE2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61086-UBE2K_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 K
    Protein Accession:
    P61086
    Secondary Accessions:
    • A6NJC1
    • A8K5Y9
    • B2RDF8
    • C9JGP1
    • O54806
    • P27924
    • Q16721
    • Q9CVV9
    • Q9Y2D3

    Protein attributes for UBE2K Gene

    Size:
    200 amino acids
    Molecular mass:
    22407 Da
    Quaternary structure:
    • Interacts with RNF138/NARF. Interacts with BRCA1.

    Three dimensional structures from OCA and Proteopedia for UBE2K Gene

    Alternative splice isoforms for UBE2K Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2K Gene

Proteomics data for UBE2K Gene at MOPED

Selected DME Specific Peptides for UBE2K Gene

Post-translational modifications for UBE2K Gene

Other Protein References for UBE2K Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2K (Ube2k)

Domains for UBE2K Gene

Gene Families for UBE2K Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Suggested Antigen Peptide Sequences for UBE2K Gene

Graphical View of Domain Structure for InterPro Entry

P61086

UniProtKB/Swiss-Prot:

UBE2K_HUMAN :
  • P61086
Domain:
  • Contains 1 UBA domain.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2K: view

Function for UBE2K Gene

Molecular function for UBE2K Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of Lys-48-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
UniProtKB/Swiss-Prot Induction: By aggregated low-density lipoprotein.

Enzyme Numbers (IUBMB) for UBE2K Gene

Gene Ontology (GO) - Molecular Function for UBE2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 17500595
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2K: view

Phenotypes for UBE2K Gene

genes like me logo Genes that share phenotypes with UBE2K: view

Animal Model Products

CRISPR Products

miRNA for UBE2K Gene

miRTarBase miRNAs that target UBE2K

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2K

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2K Gene

Localization for UBE2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2K Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2K Gene COMPARTMENTS Subcellular localization image for UBE2K gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBE2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
GO:0045111 intermediate filament cytoskeleton IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UBE2K: view

Pathways for UBE2K Gene

genes like me logo Genes that share pathways with UBE2K: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P61086-UBE2K_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8702625
GO:0008152 metabolic process --
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IBA --
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA --
genes like me logo Genes that share ontologies with UBE2K: view

Compounds for UBE2K Gene

(6) Novoseek inferred chemical compound relationships for UBE2K Gene

Compound -log(P) Hits PubMed IDs
lysine 34.4 1
cysteine 23.6 5
actinomycin d 16.3 1
atp 7 2
tyrosine 0 1
genes like me logo Genes that share compounds with UBE2K: view

Transcripts for UBE2K Gene

Unigene Clusters for UBE2K Gene

Ubiquitin-conjugating enzyme E2K:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2K

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2K Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for UBE2K Gene

GeneLoc Exon Structure for
UBE2K
ECgene alternative splicing isoforms for
UBE2K

Expression for UBE2K Gene

mRNA expression in normal human tissues for UBE2K Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2K Gene

SOURCE GeneReport for Unigene cluster for UBE2K Gene Hs.50308

mRNA Expression by UniProt/SwissProt for UBE2K Gene

P61086-UBE2K_HUMAN
Tissue specificity: Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem.
genes like me logo Genes that share expressions with UBE2K: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE2K Gene

Orthologs for UBE2K Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2K Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2K 35
  • 99.67 (n)
  • 100 (a)
UBE2K 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2K 35
  • 96.83 (n)
  • 99.5 (a)
UBE2K 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2K 35
  • 97.83 (n)
  • 100 (a)
UBE2K 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2k 35
  • 95.67 (n)
  • 100 (a)
Ube2k 16
Ube2k 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2K 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2K 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2k 35
  • 95.83 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves UBE2K 35
  • 92.33 (n)
  • 99.5 (a)
UBE2K 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2K 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia hip2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2k 35
  • 83.5 (n)
  • 97.5 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2ka 36
  • 97 (a)
OneToMany
ube2kb 35
  • 81.17 (n)
  • 97 (a)
ube2kb 36
  • 97 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004889 35
  • 65.1 (n)
  • 68.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta UbcD4 35
  • 62.98 (n)
  • 68.34 (a)
UbcD4 36
  • 68 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C28G1.10 36
  • 31 (a)
OneToMany
ubc-20 35
  • 56.28 (n)
  • 52.26 (a)
ubc-20 36
  • 52 (a)
OneToMany
ubc-21 36
  • 43 (a)
OneToMany
ubc-22 36
  • 28 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR169C 35
  • 48.88 (n)
  • 46.63 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC1 35
  • 52.2 (n)
  • 43.92 (a)
UBC1 36
  • 39 (a)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C18656g 35
  • 53.83 (n)
  • 48.65 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC27 35
  • 54.04 (n)
  • 51.05 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.6210 35
rice
(Oryza sativa)
Liliopsida Os.18673 35
Os01g0925800 35
  • 50.09 (n)
  • 50.26 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6161 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01225 35
  • 51.61 (n)
  • 48.39 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc1 35
  • 50.18 (n)
  • 44.62 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4828 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToOne
Species with no ortholog for UBE2K:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UBE2K Gene

ENSEMBL:
Gene Tree for UBE2K (if available)
TreeFam:
Gene Tree for UBE2K (if available)

Paralogs for UBE2K Gene

Pseudogenes.org Pseudogenes for UBE2K Gene

genes like me logo Genes that share paralogs with UBE2K: view

No data available for Paralogs for UBE2K Gene

Variants for UBE2K Gene

Sequence variations from dbSNP and Humsavar for UBE2K Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs149477 -- 39,733,020(-) CATTT(C/T)TAATG intron-variant
rs159986 -- 39,707,718(+) tctca(C/T)tgtgt intron-variant
rs159987 -- 39,736,052(-) AGAAT(G/T)ACTGT intron-variant
rs160088 -- 39,772,019(-) tctgc(C/T)aaaaa intron-variant
rs160096 -- 39,771,506(-) GCGGG(A/G)GTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2K Gene

Variant ID Type Subtype PubMed ID
nsv878948 CNV Loss 21882294
nsv878949 CNV Loss 21882294
dgv5528n71 CNV Loss 21882294
nsv436937 CNV Loss 16327808
nsv516320 CNV Loss 19592680
nsv878953 CNV Gain 21882294
esv2660659 CNV Deletion 23128226
nsv441870 CNV CNV 18776908
esv2727459 CNV Deletion 23290073
esv2666876 CNV Deletion 23128226
nsv518644 CNV Loss 19592680
esv2669309 CNV Deletion 23128226
nsv878954 CNV Loss 21882294
nsv528308 CNV Gain 19592680

Relevant External Links for UBE2K Gene

HapMap Linkage Disequilibrium report
UBE2K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2K Gene

Disorders for UBE2K Gene

(2) University of Copenhagen DISEASES for UBE2K Gene

(1) Novoseek inferred disease relationships for UBE2K Gene

Disease -log(P) Hits PubMed IDs
huntington disease 28.5 1
genes like me logo Genes that share disorders with UBE2K: view

No data available for UniProtKB/Swiss-Prot for UBE2K Gene

Publications for UBE2K Gene

  1. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PMID: 17873885) Christensen D.E. … Klevit R.E. (Nat. Struct. Mol. Biol. 2007) 2 3 4 23
  2. Huntingtin is ubiquitinated and interacts with a specific ubiquitin- conjugating enzyme. (PMID: 8702625) Kalchman M.A. … Hayden M.R. (J. Biol. Chem. 1996) 2 3 4
  3. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PMID: 16868077) Flierman D. … Chau V. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 23
  4. Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. (PMID: 10634809) Kikuchi J. … Sakurabayashi I. (Arterioscler. Thromb. Vasc. Biol. 2000) 3 4 23
  5. Recent advances on the pathogenesis of Huntington's disease. (PMID: 10222105) PetersAcn A. … Brundin P. (Exp. Neurol. 1999) 3 23

Products for UBE2K Gene

  • Addgene plasmids for UBE2K

Sources for UBE2K Gene

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