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Aliases for UBE2K Gene

Aliases for UBE2K Gene

  • Ubiquitin Conjugating Enzyme E2 K 2 3 5
  • Ubiquitin-Conjugating Enzyme E2K (UBC1 Homolog, Yeast) 2 3
  • Ubiquitin-Conjugating Enzyme E2(25K) 3 4
  • E2 Ubiquitin-Conjugating Enzyme K 3 4
  • Huntingtin-Interacting Protein 2 3 4
  • Ubiquitin Carrier Protein 3 4
  • Ubiquitin-Protein Ligase 3 4
  • HIP-2 3 4
  • HIP2 3 4
  • LIG 3 4
  • Ubiquitin-Conjugating Enzyme E2-25 KDA 3
  • Ubiquitin-Conjugating Enzyme E2-25 KDa 4
  • Ubiquitin-Conjugating Enzyme E2-25K 4
  • Ubiquitin-Conjugating Enzyme E2 K 3
  • Huntingtin Interacting Protein 2 2
  • Ubiquitin-Conjugating Enzyme E2K 2
  • Ubiquitin Conjugating Enzyme E2K 3
  • EC 6.3.2.19 61
  • EC 2.3.2.23 4
  • E2(25K) 3
  • E2-25K 3
  • HYPG 3
  • UBC1 3

External Ids for UBE2K Gene

Previous HGNC Symbols for UBE2K Gene

  • HIP2

Previous GeneCards Identifiers for UBE2K Gene

  • GC04P039377
  • GC04P039024

Summaries for UBE2K Gene

Entrez Gene Summary for UBE2K Gene

  • The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2K Gene

UBE2K (Ubiquitin Conjugating Enzyme E2 K) is a Protein Coding gene. Diseases associated with UBE2K include Huntington Disease and Autistic Disorder. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for UBE2K Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of Lys-48-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

Gene Wiki entry for UBE2K Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2K Gene

Genomics for UBE2K Gene

Regulatory Elements for UBE2K Gene

Enhancers for UBE2K Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F039695 0.9 ENCODE 10.8 +0.4 380 5.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 RPL9 FAM114A1 UBE2K UGDH-AS1 RBM47 ENSG00000252975 GC04M039712
GH04F039682 0.6 Ensembl 9.8 -15.6 -15644 0.4 PKNOX1 CBX5 TCF7 CREM LOC105374419 SMIM14 UBE2K
GH04F039705 1.2 Ensembl ENCODE 5.2 +8.7 8718 1.7 KLF1 JUNB ZNF384 ZEB2 TBX21 ZNF121 OSR2 JUND CBX5 IKZF1 RPL9 UBE2K ENSG00000252975 GC04M039712
GH04F039711 0.6 Ensembl 5.2 +15.4 15357 3.2 TEAD1 CEBPB JUNB CHD4 TRIM22 CEBPG TEAD3 EED IKZF1 CEBPA RPL9 UBE2K ENSG00000249019 ENSG00000252975 GC04M039712
GH04F039729 0.6 Ensembl 5.1 +31.8 31757 0.4 ZNF121 UBE2K ENSG00000249019 RN7SL558P
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UBE2K on UCSC Golden Path with GeneCards custom track

Promoters for UBE2K Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001239696 1156 3600 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ZNF2 YY1 GLIS2

Genomic Location for UBE2K Gene

Chromosome:
4
Start:
39,698,044 bp from pter
End:
39,782,792 bp from pter
Size:
84,749 bases
Orientation:
Plus strand

Genomic View for UBE2K Gene

Genes around UBE2K on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2K Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2K Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2K Gene

Proteins for UBE2K Gene

  • Protein details for UBE2K Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61086-UBE2K_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 K
    Protein Accession:
    P61086
    Secondary Accessions:
    • A6NJC1
    • A8K5Y9
    • B2RDF8
    • C9JGP1
    • O54806
    • P27924
    • Q16721
    • Q9CVV9
    • Q9Y2D3

    Protein attributes for UBE2K Gene

    Size:
    200 amino acids
    Molecular mass:
    22407 Da
    Quaternary structure:
    • Interacts with RNF138/NARF. Interacts with BRCA1.

    Three dimensional structures from OCA and Proteopedia for UBE2K Gene

    Alternative splice isoforms for UBE2K Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2K Gene

Selected DME Specific Peptides for UBE2K Gene

P61086:
  • GPPDTPY
  • RIKREFKEV
  • ICLDILK
  • PETYPFNPPKVRFIT
  • TLRTVLLSLQA

Post-translational modifications for UBE2K Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2K (UBE2K)
  • Cloud-Clone Corp. Antibodies for UBE2K

Domains & Families for UBE2K Gene

Gene Families for UBE2K Gene

Graphical View of Domain Structure for InterPro Entry

P61086

UniProtKB/Swiss-Prot:

UBE2K_HUMAN :
  • Contains 1 UBA domain.
  • Belongs to the ubiquitin-conjugating enzyme family.
Domain:
  • Contains 1 UBA domain.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2K: view

Function for UBE2K Gene

Molecular function for UBE2K Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of Lys-48-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.
UniProtKB/Swiss-Prot Induction:
By aggregated low-density lipoprotein.

Enzyme Numbers (IUBMB) for UBE2K Gene

Gene Ontology (GO) - Molecular Function for UBE2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA,TAS 20061386
GO:0005515 protein binding IPI 17500595
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 16714285
genes like me logo Genes that share ontologies with UBE2K: view
genes like me logo Genes that share phenotypes with UBE2K: view

Animal Model Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2K Gene

Localization for UBE2K Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2K Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2K Gene COMPARTMENTS Subcellular localization image for UBE2K gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBE2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA,IBA --
GO:0032433 filopodium tip IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with UBE2K: view

Pathways & Interactions for UBE2K Gene

genes like me logo Genes that share pathways with UBE2K: view

Pathways by source for UBE2K Gene

UniProtKB/Swiss-Prot P61086-UBE2K_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2K Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8702625
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA 24882218
GO:0010994 free ubiquitin chain polymerization IDA 24882218
GO:0016567 protein ubiquitination IEA --
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with UBE2K: view

No data available for SIGNOR curated interactions for UBE2K Gene

Drugs & Compounds for UBE2K Gene

(7) Drugs for UBE2K Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(2) Additional Compounds for UBE2K Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2K: view

Transcripts for UBE2K Gene

Unigene Clusters for UBE2K Gene

Ubiquitin-conjugating enzyme E2K:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2K Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7
SP1: -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for UBE2K Gene

GeneLoc Exon Structure for
UBE2K
ECgene alternative splicing isoforms for
UBE2K

Expression for UBE2K Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2K Gene

Protein differential expression in normal tissues from HIPED for UBE2K Gene

This gene is overexpressed in Breast (9.5) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2K Gene



Protein tissue co-expression partners for UBE2K Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2K Gene:

UBE2K

SOURCE GeneReport for Unigene cluster for UBE2K Gene:

Hs.50308

mRNA Expression by UniProt/SwissProt for UBE2K Gene:

P61086-UBE2K_HUMAN
Tissue specificity: Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellum and brainstem.
genes like me logo Genes that share expression patterns with UBE2K: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBE2K Gene

Orthologs for UBE2K Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2K Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2K 35
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2K 34 35
  • 99.67 (n)
oppossum
(Monodelphis domestica)
Mammalia UBE2K 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2K 34 35
  • 97.83 (n)
cow
(Bos Taurus)
Mammalia UBE2K 34 35
  • 96.83 (n)
rat
(Rattus norvegicus)
Mammalia Ube2k 34
  • 95.83 (n)
mouse
(Mus musculus)
Mammalia Ube2k 34 16 35
  • 95.67 (n)
chicken
(Gallus gallus)
Aves UBE2K 34 35
  • 92.33 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2K 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2k 34
  • 83.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia hip2-prov 34
zebrafish
(Danio rerio)
Actinopterygii ube2ka 35
  • 97 (a)
OneToMany
ube2kb 34 35
  • 81.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004889 34
  • 65.1 (n)
fruit fly
(Drosophila melanogaster)
Insecta UbcD4 34 35
  • 62.98 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-20 34 35
  • 56.28 (n)
ubc-21 35
  • 43 (a)
OneToMany
C28G1.10 35
  • 31 (a)
OneToMany
ubc-22 35
  • 28 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C18656g 34
  • 53.83 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC1 34 35
  • 52.2 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR169C 34
  • 48.88 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC27 34
  • 54.04 (n)
rice
(Oryza sativa)
Liliopsida Os01g0925800 34
  • 50.09 (n)
Os.18673 34
barley
(Hordeum vulgare)
Liliopsida Hv.6210 34
wheat
(Triticum aestivum)
Liliopsida Ta.6161 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU01225 34
  • 51.61 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc1 34
  • 50.18 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4828 34
Species where no ortholog for UBE2K was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UBE2K Gene

ENSEMBL:
Gene Tree for UBE2K (if available)
TreeFam:
Gene Tree for UBE2K (if available)

Paralogs for UBE2K Gene

Pseudogenes.org Pseudogenes for UBE2K Gene

genes like me logo Genes that share paralogs with UBE2K: view

No data available for Paralogs for UBE2K Gene

Variants for UBE2K Gene

Sequence variations from dbSNP and Humsavar for UBE2K Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001359 -- 39,725,560(+) ggtca(A/G/T)ttagc intron-variant
rs10004937 -- 39,710,252(+) TGCCT(A/G)CTGTC intron-variant
rs10005267 -- 39,740,680(+) ACACG(A/G)TGAAA intron-variant
rs10006221 -- 39,701,879(+) cctta(C/G)cctcc intron-variant
rs10007152 -- 39,710,072(+) TAAAA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2K Gene

Variant ID Type Subtype PubMed ID
dgv1475e212 CNV loss 25503493
dgv5193n100 CNV gain 25217958
dgv9016n54 CNV loss 21841781
dgv9017n54 CNV loss 21841781
dgv9018n54 CNV loss 21841781
esv2660659 CNV deletion 23128226
esv2666876 CNV deletion 23128226
esv2669309 CNV deletion 23128226
esv2727459 CNV deletion 23290073
esv3563738 CNV deletion 23714750
esv3563739 CNV deletion 23714750
esv3600289 CNV loss 21293372
esv3600290 CNV loss 21293372
esv3600291 CNV loss 21293372
nsv436937 CNV loss 16327808
nsv441870 CNV loss 18776908
nsv516320 CNV loss 19592680
nsv518644 CNV loss 19592680
nsv528308 CNV gain 19592680
nsv594014 CNV loss 21841781
nsv594026 CNV loss 21841781
nsv594029 CNV loss 21841781
nsv594030 CNV gain 21841781
nsv967738 CNV duplication 23825009

Variation tolerance for UBE2K Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.09; 2.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2K Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2K

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2K Gene

Disorders for UBE2K Gene

MalaCards: The human disease database

(2) MalaCards diseases for UBE2K Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • congenital anomalies of kidney and urinary tract 2
autistic disorder
  • autism
- elite association - COSMIC cancer census association via MalaCards
Search UBE2K in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBE2K

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2K
genes like me logo Genes that share disorders with UBE2K: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2K Gene

Publications for UBE2K Gene

  1. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PMID: 17873885) Christensen D.E. … Klevit R.E. (Nat. Struct. Mol. Biol. 2007) 2 3 4 22 64
  2. E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PMID: 16868077) Flierman D. … Chau V. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 4 22 64
  3. Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. (PMID: 10634809) Kikuchi J. … Sakurabayashi I. (Arterioscler. Thromb. Vasc. Biol. 2000) 3 4 22 64
  4. Huntingtin is ubiquitinated and interacts with a specific ubiquitin- conjugating enzyme. (PMID: 8702625) Kalchman M.A. … Hayden M.R. (J. Biol. Chem. 1996) 2 3 4 64
  5. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4 64

Products for UBE2K Gene

Sources for UBE2K Gene

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