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UBE2K Gene

protein-coding GIFtS: 51

GC04P039377

ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
(Previous name: huntingtin interacting protein 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: HIP2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp564C1216 ^²
DKFZp686J24237 ^²
E2(25K) ^³
E2-25K ^², ³
EC 6.3.2.19 ^³
HIP-2 ^³
HIP2 ^², ³
HYPG ^¹, ²
LIG ^², ³

Descriptions
Huntingtin-interacting protein 2 ^³
Ubiquitin carrier protein ^², ³
Ubiquitin-conjugating enzyme E2-25 kDa ^², ³
Ubiquitin-protein ligase ^², ³
huntingtin interacting protein 2 ^¹, ²
ubiquitin-conjugating enzyme E2-25K ^²
ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast) ^²

External Ids
HGNC: 4914¹
Entrez Gene: 3093²
UniProtKB: P61086³
Ensembl: ENSG00000078140⁷

Search outside databases for aliases for UBE2K gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2K:

The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein

interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for

Huntington's disease. Known functions for this protein include a role in aggregate formation

of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a

role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic

reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different

isoforms have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Ubiquitinates huntingtin. May mediate foam cell

formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and

subsequence degradation of p53

Gene Wiki entry for UBE2K (HIP2)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p14 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p14

UBE2K Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P039377: (about GC identifiers)

Start:	39,376,205 bp from pter
End:	39,457,977 bp from pter
Size:	81,773 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000004.10 NT_016297.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 K

Size: 200 amino acids; 22407 Da

Subunit: Interacts with RNF138/NARF

Subcellular location: Cytoplasm (By similarity)

PDB structures from and Proteopedia :

1YLA (3D)

2O25 (3D)

3E46 (3D)

3F92 (3D)

Secondary accessions: A6NJC1 B2RDF8 O54806 P27924 Q16721 Q9CVV9 Q9Y2D3

Alternative splicing: 2 isoforms: P61086-1 P61086-2

Post-translational modifications:

Sumoylation at Lys-14 impairs catalytic activity (By similarity)¹

REFSEQ proteins (3 alternative transcripts):

NP_001104582.1 NP_001104583.1 NP_005330.1

ENSEMBL proteins:

ENSP00000295963 ENSP00000261427

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (HIP2)
	Human Recombinant Proteins from Abnova (UBE2K)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for UBE2K:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE2K
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for UBE2K (HIP2)
	Antibodies from Abcam (HIP2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2K)
	Novus Biologicals Antibodies for UBE2K

Assays for UBE2K:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P61086

ProtoNet protein and cluster: P61086

UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086

Similarity: Belongs to the ubiquitin-conjugating enzyme family

Similarity: Contains 1 UBA domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2K)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2K)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001111112

Applied Biosystems Silencer® siRNAs for UBE2K

Sigma-Aldrich siRNA and siRNA Panels for UBE2K

Sigma-Aldrich shRNA Panels and shRNA for UBE2K

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2K
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001111112
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001111112
untagged cDNA clones in CMV expression vector (see all 4): BC006419

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005339

UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Ubiquitinates huntingtin. May mediate foam cell

formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and

subsequence degradation of p53

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Induction: By aggregated low-density lipoprotein

Enzyme Number (IUBMB): EC 6.3.2.19

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ube2k):

nervous system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	8702625
GO:0005515	protein binding	IPI	17353931
GO:0016874	ligase activity	IEA	--
GO:0031625	ubiquitin protein ligase binding	IPI	16714285

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for UBE2K (Your Favorite Gene powered by Ingenuity)

NRF2-mediated Oxidative Stress Response

GeneDecks UBE2K for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2K

2 Interacting proteins for UBE2K (P61086^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DSTYK	Q6XUX3¹	EBI-473850, EBI-1049520
PIAS4	Q8N2W9²	MINT-3980642

About this table
3 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8702625
GO:0043687 post-translational protein modification IEA --
GO:0051246 regulation of protein metabolic process IEA --
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2K
3 Novoseek chemical compound relationships for UBE2K gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	31.23	1	14517261 (1)
atp	9.33	2	8034027 (1), 16275321 (1)
tyrosine	0.00	1	10966114 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2K)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2K)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001111112

Sigma-Aldrich siRNA and siRNA Panels for UBE2K

Sigma-Aldrich shRNA Panels and shRNA for UBE2K

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001111112 NM_001111113 NM_005339

REFSEQ mRNAs for UBE2K gene (3 alternative transcripts):

NM_001111112.1 NM_001111113.1 NM_005339.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001111112 NM_001111113 NM_005339

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001111112
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001111112
                                 untagged cDNA clones in CMV expression vector (see all 4): BC006419

Additional cDNA sequence:

AB022435.1 AB022436.1 AK093533.1 AK291454.1 AK295846.1 AK307130.1 AK315524.1 AL117568.1

BC022804.1 BC050600.1 BX641089.1 CR606205.1 CR621318.1 U58522.1

20 DOTS entries:

DT.453166 DT.97780192 DT.92442814 DT.91742775 DT.95364285 DT.75154564 DT.100718402 DT.95364286

DT.100813999 DT.92442822 DT.95364298 DT.100763089 DT.91812239 DT.91828453 DT.92442819 DT.102834685

DT.40111771 DT.75187719 DT.92442816 DT.95364296

24/407 AceView cDNA sequences (see all 407 ):

BQ001696 AI080393 CA453659 CF128356 AA747449 AI074875 BM992652 AI240124

AW902374 BC050600 AA344326 AI708378 BQ417090 BX106212 AA588232 AI094629

R29740 AU134343 BQ006001 BI438859 AW316739 AA334798 AA970776 F07267

Unigene Cluster for UBE2K:

Ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)

Hs.714332 [show with all ESTs]

Unigene Representative Sequence: NM_005339

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2K (see all 6 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7
SP1:									-
SP2:							-		-
SP3:									-												-		-		-
SP4:									-		-
SP5:									-		-		-

About this scheme

ECgene alternative splicing isoforms for UBE2K

2 Ensembl transcripts including schematic representations:

ENST00000295963 ENST00000261427

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2K expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2K

¹ / ²

7 probe-sets matching UBE2K gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40121_at²	U95-A	2	1.00	0.97	1.00	1.00	--	--	--	--	--
202347_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
202346_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
225179_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
202347_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202346_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225179_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGATGTAGAG

SOURCE GeneReport for Unigene cluster: Hs.714332
UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086
Tissue specificity: Expressed in all tissues tested, including spleen, thymus, prostate, testis,
ovary, small intestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes
and bone marrow mononuclear cells. Highly expressed in brain, with highest levels found in cortex
and striatum and at lower levels in cerebellum and brainstem

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2K gene from 5/24 species (see all 24 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2K¹	--	ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)	97.83(n) 100(a)	609531 XM_846094.1 XP_851187.1
chimpanzee (Pan troglodytes)	UBE2K¹	--	ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)	100(n) 100(a)	461178 XM_517157.2 XP_517157.1
cow (Bos taurus)	UBE2K¹	--	ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)	96.83(n) 99.5(a)	281225 NM_174080.2 NP_776505.1
rat (Rattus norvegicus)	Ube2k¹	--	ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)	95.83(n) 100(a)	289623 XM_214043.4 XP_214043.1
mouse (Mus musculus)	Ube2k^{1, 5}	5 (39.00 cM)⁵	ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)^{1, 5}	95.67(n)¹ 100(a)¹	53323¹ NM_016786.3¹ NP_058066.2¹ AA675224⁵ AB011081⁵ (see all 26)

About this table Species with no ortholog for UBE2K

ENSEMBL Gene Tree for UBE2K

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2K gene

UBE2T² UBE2NL² UBE2N²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/674 NCBI SNPs in UBE2K are shown (see all 674 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 118)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs3912392^1,2	A,C,F,H	39375133(+)	`ccgccG/AcgccA`	1	--	ng5¹		4		EU EA WA	418
--	rs3912391^1,2	A,C,F,H	39375219(+)	`tttgaG/Agccta`	1	--	ng5¹		4		EU EA WA	412
--	rs305112^1,2	A,C,F	39460124(-)	`AGGGTA/GTATCA`	3	--	ut3¹		10		EA NA MN	436
--	rs7658679^1,2	A,C	39374566(+)	`agtctC/Tgctcc`	1	--	ng5¹		0	--	--	--	--
--	rs9996828^1,2	A,C	39374811(+)	`ggattA/Gcaggc`	1	--	ng5¹		0	--	--	--	--
--	rs6531737^1,2	C	39374993(+)	`gcgatG/Tttcct`	1	--	ng5¹		0	--	--	--	--
	rs1064268^1,2	H	39457078(+)	`CCTTGC/GCACAC`	3	--	ut3¹ ese³		4		EU EA WA	418
	rs438344^1,2	A,C,F,H,O	39436870(+)	`AAACAT/CTTTCT`	1	--	int¹		7		EU EA WA NA	560
	rs725856^1,2	A,C,F,H,O	39424673(+)	`CCACAA/GTGTGG`	1	--	int¹		5		MN EU EA WA	602
	rs463918^1,2	A,C,F,H,O	39453011(-)	`GCAAAC/G/TCACTG`	1	--	int¹		8		EA NA MN EU	500

About this table

HapMap Linkage Disequilibrium images for UBE2K (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602846

1 Novoseek disease relationship for UBE2K gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
huntington disease	30.95	2	10585161 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/95 PubMed articles for UBE2K gene (see all 95 ):

Huntingtin is ubiquitinated and interacts with a specific ubiquitin- conjugating enzyme. (PubMed id 8702625)^{2, 3, 4} Kalchman M.A.... Hayden M.R. (1996)
Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. (PubMed id 10634809)^{1, 3, 4} Kikuchi J.... Sakurabayashi I. (2000)
E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PubMed id 17873885)^{1, 2, 3} Christensen D.E....Klevit R.E. (2007)
NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PubMed id 16714285)^{3, 4} Yamada M.... Shibuya H. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
Regulation of macrophage-specific gene expression by degenerated lipoproteins. (PubMed id 10675012)^{3, 4} Furukawa Y....Sakurabayashi I. (2000)
E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. (PubMed id 11513855)^{1, 3} Lee S.-J.... Kang S. (2001)
E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PubMed id 16868077)^{1, 3} Flierman D.... Chau V. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3093	HGNC: 4914	AceView: HIP2	Ensembl:ENSG00000078140	euGenes: HUgn3093
ECgene: UBE2K	H-InvDB: UBE2K

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for UBE2K
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBE2K:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2K-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2K		Antibodies for UBE2K
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE2K		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBE2K)
	Antibodies (UBE2K)
	Chimera RNAi (UBE2K)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for UBE2K (HIP2)

	Recombinant Proteins (HIP2)
	Antibodies (HIP2)

Search OriGene for UBE2K

Search Tocris compounds for UBE2K

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for UBE2K

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UBE2K Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for UBE2K

Summaries
for UBE2K

Genomic Location
for UBE2K

Proteins
for UBE2K

Protein Domains/
Families
for UBE2K

Gene Function
for UBE2K

Pathways & Interactions
for UBE2K

Drugs & Compounds
for UBE2K

Transcripts
for UBE2K

Expression
for UBE2K

Orthologs
for UBE2K

Paralogs
for UBE2K

SNPs/Variants
for UBE2K

Disorders & Mutations
for UBE2K

Medical News
for UBE2K

Publications
for UBE2K

Search for UBE2K

Genome Databases showing UBE2K

Other Databases showing UBE2K

Specialized Databases showing UBE2K

Licensable Technologies
for UBE2K

Services
for UBE2K

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2K Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor UBE2K

Summariesfor UBE2K

Genomic Locationfor UBE2K

Proteinsfor UBE2K

Protein Domains/Familiesfor UBE2K

Gene Functionfor UBE2K

Pathways & Interactionsfor UBE2K

Drugs & Compoundsfor UBE2K

Transcriptsfor UBE2K

Expression for UBE2K

Orthologsfor UBE2K

Paralogsfor UBE2K

SNPs/Variantsfor UBE2K

Disorders & Mutationsfor UBE2K

Medical Newsfor UBE2K

Publicationsfor UBE2K

Search for UBE2K

Genome Databases showing UBE2K

Other Databases showing UBE2K

Specialized Databases showing UBE2K

Licensable Technologiesfor UBE2K

Servicesfor UBE2K

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2K

Summaries
for UBE2K

Genomic Location
for UBE2K

Proteins
for UBE2K

Protein Domains/
Families
for UBE2K

Gene Function
for UBE2K

Pathways & Interactions
for UBE2K

Drugs & Compounds
for UBE2K

Transcripts
for UBE2K

Expression
for UBE2K

Orthologs
for UBE2K

Paralogs
for UBE2K

SNPs/Variants
for UBE2K

Disorders & Mutations
for UBE2K

Medical News
for UBE2K

Publications
for UBE2K

Licensable Technologies
for UBE2K

Services
for UBE2K