UBE2K Gene
protein-coding GIFtS: 61
GCID: GC04P039700
|
|
ubiquitin-conjugating enzyme E2K(Previous names: huntingtin interacting protein 2, ubiquitin-conjugating...)
(Previous symbol: HIP2)
| |
Aliases
for UBE2K gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2K1 2 | | Ubiquitin-Conjugating Enzyme E2-25 KDa2 3 | | HIP21 2 3 5 | | Ubiquitin-Conjugating Enzyme E2-25K2 3 | | HYPG1 2 | | Ubiquitin-Protein Ligase2 3 | | UBC11 2 | | HIP-22 3 | | Huntingtin Interacting Protein 21 2 | | LIG2 3 | | Ubiquitin-Conjugating Enzyme E2K (UBC1 Homolog, Yeast)1 2 | | EC 6.3.2.193 8 | | Huntingtin-Interacting Protein 22 3 | | E2(25K)2 | | Ubiquitin Carrier Protein2 3 | | E2-25K2 | | Ubiquitin-Conjugating Enzyme E2(25K)2 3 | | Ubiquitin-Conjugating Enzyme E2 K2 |
Export aliases for UBE2K gene to outside databasesPrevious GC identifers: GC04P039377 GC04P039024 |
Summaries
for UBE2K gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2K:
The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RINGfinger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions forthis protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosisin polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from theendoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding differentisoforms have been identified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, inthe presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinatedsubstrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmicreticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cellformation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequencedegradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitrosupports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependentdegradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infectionsmay be involved in the HPV E7 protein-dependent degradation of RB1
Gene Wiki entry for UBE2K (HIP2)
|
Genomic Views
for UBE2K gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016297.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2K gene promoter:
Nkx3-1 ER-alpha Nkx3-1 v4 AP-1 ATF-2 Nkx3-1 v1 Nkx3-1 v2 Nkx3-1 v3 IRF-7A c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2K
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2K |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p14 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p14UBE2K Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P039700: view genomic region
(about GC identifiers)
Start:
|
39,699,664 bp from pter |
End:
|
39,784,412 bp from pter |
Size:
|
84,749 bases |
Orientation:
|
plus strand |
|
Proteins
for UBE2K gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 K Size: 200 amino acids; 22407 Da
Subunit: Interacts with RNF138/NARF. Interacts with BRCA1
Subcellular location: Cytoplasm (By similarity)
6 PDB 3D structures from  and Proteopedia  for UBE2K:1YLA (3D)
2O25 (3D)
3E46 (3D)
3F92 (3D)
3K9O (3D)
3K9P (3D)
Secondary accessions: A6NJC1 A8K5Y9 B2RDF8 C9JGP1 O54806 P27924 Q16721 Q9CVV9 Q9Y2D3Alternative splicing: 3 isoforms: P61086-1 P61086-2 P61086-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBE2K: NX_P61086
Post-translational modifications:
Sumoylation at Lys-14 impairs catalytic activity (By similarity)1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P61086
4/5 DME Specific Peptides for UBE2K (P61086) (see all 5)
UBE2K Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001104582.1 NP_001104583.1 NP_005330.1
ENSEMBL proteins: ENSP00000261427 ENSP00000425301 ENSP00000421203 ENSP00000390483 ENSP00000421422 ENSP00000295963 Reactome Protein details: P61086
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
UBE2K for ontologies About GeneDecksing
UBE2K Antibody Products:
Assay Products for UBE2K: |
Protein
Domains /
Families
for UBE2K gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2K for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P61086ProtoNet protein and cluster: P61086 UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086Similarity: Belongs to the ubiquitin-conjugating enzyme familySimilarity: Contains 1 UBA domain |
Function
for UBE2K gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, inthe presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinatedsubstrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmicreticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cellformation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequencedegradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitrosupports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependentdegradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infectionsmay be involved in the HPV E7 protein-dependent degradation of RB1Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineInduction: By aggregated low-density lipoproteinEnzyme Number (IUBMB): EC 6.3.2.191 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2K (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2K (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): UBE2K (NM_005339) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2K | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2K |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2K |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
UBE2K for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for UBE2K:
Animal Models:
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ube2k):
UBE2K for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBE2K gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | | | 3 | RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 | | | 4 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | | | 5 | Protein Stability | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for UBE2K
5/11 
Reactome Pathways for UBE2K (see all 11)
1 
Kegg Pathway (Kegg details for UBE2K):
UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086Pathway: Protein modification; protein ubiquitination
UBE2K for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2K
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/99 Interacting proteins for UBE2K (P610862, 3 ENSP000002614274) via UniProtKB, MINT, STRING, and/or I2D (see all 99)
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006511 | ubiquitin-dependent protein catabolic process |
TAS | 8702625 | | GO:0016567 | protein ubiquitination |
-- | -- | | GO:0070936 | protein K48-linked ubiquitination |
IDA | -- |
UBE2K for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2K gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UBE2K for compounds About GeneDecksing
 Browse Tocris compounds for UBE2K
6 Novoseek chemical compound relationships for UBE2K gene About this table
Search CenterWatch for drugs/clinical trials and news about UBE2K
|
Transcripts
for UBE2K gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE2K gene (3 alternative transcripts): NM_001111112.1 NM_001111113.1 NM_005339.4 Unigene Cluster for UBE2K: Ubiquitin-conjugating enzyme E2K Hs.50308 [show with all ESTs]Unigene Representative Sequence: NM_0053398 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261427(uc003guu.4 uc003gus.4 uc003gut.4 uc010ifn.3 uc011byq.2 uc003guq.4)
ENST00000510934 ENST00000513231 ENST00000438068 ENST00000503368 ENST00000445950
ENST00000510719 ENST00000295963
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2K (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2K (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): UBE2K (NM_005339) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2K | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2K |
Additional cDNA sequence: AB022435.1 AB022436.1 AK093533.1 AK291454.1 AK295846.1 AK307130.1 AK315524.1 AL117568.1 BC022804.1 BC050600.1 BX641089.1 U58522.1 21 DOTS entries: DT.92442814 DT.453166 DT.97780192 DT.95364285 DT.100718402 DT.75154564 DT.95364286 DT.100777751 DT.100813999 DT.95364298 DT.100763089 DT.91812239 DT.91828453 DT.95364296 DT.102834685 DT.40111771 DT.75187719 DT.91742775 DT.92442816 DT.92442819 DT.92442822 24/407 AceView cDNA sequences (see all 407): AA588232 Z39934 CB118282 BI712697 CA311662 AK093533 CA423743 BI712458 F07267 AA298821 BM762341 AI094629 AA618570 CD674135 CR606205 H66963 BC022804 AA334798 BE714576 AA146991 Z43868 CF138466 AA629826 BX427147
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2K (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | | | - | | - | | - | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBE2K
|
Expression
for UBE2K gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2K expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGATGTAGAG
About this image
See UBE2K Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2K
SOURCE GeneReport for Unigene cluster: Hs.50308
UniProtKB/Swiss-Prot: UBE2K_HUMAN, P61086Tissue specificity: Expressed in all tissues tested, including spleen, thymus, prostate, testis, ovary, smallintestine, colon, peripheral blood leukocytes, T-lymphocytes, monocytes, granulocytes and bone marrow mononuclearcells. Highly expressed in brain, with highest levels found in cortex and striatum and at lower levels in cerebellumand brainstem
SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2K:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2K
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2K | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2K | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2K | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2K |
Orthologs
for UBE2K gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2K gene from 9/36 species (see all 36) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
UBE2K1 |
ubiquitin-conjugating enzyme E2K |
92.33(n)
99.5(a) |
|
428787 NM_001031540.1 NP_001026711.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UBE2K6 |
-- |
90(a) |
1 ↔ 1 |
5(99793960-99812006) |
African clawed frog
(Xenopus laevis) |
Amphibia |
hip2-prov2 |
huntingtin interacting protein 2 |
84.14(n) |
|
BC041728.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ube2kb1 |
ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) |
81.17(n)
97(a) |
|
30100 NM_001008611.2 NP_001008611.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
UbcD41 |
Ubiquitin conjugating enzyme 4 |
62.98(n)
68.34(a) |
|
39133 NM_079286.2 NP_524010.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
ubc-201 |
Protein UBC-20 |
56.28(n)
52.26(a) |
|
175185 NM_064773.3 NP_497174.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UBC11 |
Ubc1p |
52.03(n)
43.92(a) |
|
851757 NP_010462.3 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBC271 |
ubiquitin-conjugating enzyme E2 27 |
52.81(n)
49.47(a) |
|
835159 NM_124465.5 NP_199900.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.186732 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
80.85(n) |
|
AK073357.1 |
ENSEMBL Gene Tree for UBE2K (if available)
TreeFam Gene Tree for UBE2K (if available) |
Paralogs
for UBE2K gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE2K gene
18/23 SIMAP similar genes for UBE2K using alignment to 5 protein entries: UBE2K_HUMAN (see all proteins)
(see all similar genes):HIP2 UBE2D3 UBE2D2 UBE2D1 UBE2D4 UBE2M
UBE2H UBE2A UBE2B UBE2NL UBE2C UBE2G1
UBE2E1 UBE2S UBE2E2 UBE2E3 UBE2L3 UBE2T
UBE2K for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UBE2K
PGOHUM00000245096
|
Genomic Variants
for UBE2K gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for UBE2K
4 CNVs: 1387 51397 51396 38552
1 Indel: 51398 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2K |
|
Disorders
/ Diseases
for UBE2K gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2K for disorders About GeneDecksing
OMIM gene information: 602846
OMIM disorders: --
20  diseases for UBE2K: About MalaCardshuntington's disease dna topoisomerase ii pancoast tumor liddle syndrome
breast cancer susceptibility autistic disorder fanconi's anemia angelman syndrome
leptospirosis cblc breast cancer hepatitis c
parkinson's disease anemia alzheimer's disease atherosclerosis
hepatitis cerebritis malaria prostatitis
1 disease from the University of Copenhagen DISEASES database for UBE2K:Pancoast tumor 1 Novoseek disease relationship for UBE2K gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| huntington disease |
28.5 |
2 |
10585161 (1) |
Export disorders for UBE2K gene to outside databases
|
Publications
for UBE2K gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBE2K gene, integrated from 9 sources (see all 136):
(articles sorted by number of sources associating them with UBE2K) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PubMed id 17873885)1, 2, 3, 9 Christensen D.E....Klevit R.E. (2007)
- Huntingtin is ubiquitinated and interacts with a specific ubiquitin- conjugating enzyme. (PubMed id 8702625)1, 2, 3 Kalchman M.A.... Hayden M.R. (1996)
- Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. (PubMed id 10634809)1, 2, 9 Kikuchi J.... Sakurabayashi I. (2000)
- E2-25K mediates US11-triggered retro-translocation of MHC class I heavy chains in a permeabilized cell system. (PubMed id 16868077)1, 2, 9 Flierman D.... Chau V. (2006)
- NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF). (PubMed id 16714285)1, 2 Yamada M.... Shibuya H. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
- Regulation of macrophage-specific gene expression by degenerated lipoproteins. (PubMed id 10675012)1, 2 Furukawa Y....Sakurabayashi I. (2000)
- E3 ligase activity of RING finger proteins that interact with Hip-2, a human ubiquitin-conjugating enzyme. (PubMed id 11513855)1, 9 Lee S.-J.... Kang S. (2001)
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External Searches for UBE2K gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing UBE2K gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing UBE2K gene
(According to HUGE)
About This Section
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Specialized Databases showing UBE2K gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for UBE2K | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for UBE2K gene:
Search GeneIP for patents involving UBE2K
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UBE2K gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for UBE2K | | OriGene shRNA RFP for UBE2K | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2K | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2K | | | OriGene Protein Over-expression Lysate for UBE2K | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for UBE2K | | OriGene 3'-UTR Clone for UBE2K | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2K | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2K | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBE2K | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for UBE2K | | OriGene Custom Protein Services for UBE2K | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2K | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2K | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2K | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2K | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2K | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2K |
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| | Antibodies & Assays for UBE2K |
| | | | Search Tocris compounds for UBE2K |
| |  |  |  |  | | | | | | Recombinant Protein for UBE2K |
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 | | | UBE2K Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2K |
|  |  |  | | | | ThermoFisher Antibodies for UBE2K |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2K |
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