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Aliases & Descriptions for UBE2J2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 6.3.2.19 3 NCUBE2 1 , 2 , 3 OTTHUMP00000001907 2 OTTHUMP00000002078 2 PRO2121 2 Ubc6p 1
Descriptions Non-canonical ubiquitin-conjugating enzyme 2 3 ubiquitin conjugating enzyme 6 2 ubiquitin conjugating enzyme E2, J2 2 ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) 2 yeast UBC6 homolog 2
Search outside databases for aliases for UBE2J2 genePrevious GC identifers: GC01M000941 GC01M001066 GC01M001095 GC01M001229
Summaries for UBE2J2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for UBE2J2 : The modification of proteins with ubiquitin is an important cellular mechanism for targetingabnormal or short-lived proteins for degradation. Ubiquitination involves at least three classesof enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, andubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugatingenzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiplealternatively spliced transcript variants have been found for this gene, but the full-lengthnature of some variants has not been defined. [provided by RefSeq] UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1 Function : Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function inthe selective degradation of misfolded membrane proteins from the endoplasmic reticulum (Bysimilarity)
Genomic Location for UBE2J2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the UBE2J2 gene Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33 UBE2J2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M001182:
(about GC identifiers )
Start:
1,179,155 bp from pter
End:
1,199,097 bp from pter
Size:
19,943 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004350.18 Proteins for UBE2J2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1 (See
protein sequence )Recommended Name: Ubiquitin-conjugating enzyme E2 J2 Size : 259 amino acids; 28925 Da
Subcellular location : Endoplasmic reticulum membrane; Single-pass type IV membrane protein (Bysimilarity)
PDB structures from and Proteopedia : 2F4W (3D)
 
Secondary accessions : Q96N26 Q96T84Alternative splicing : 2 isoforms : Q8N2K1-1 Q8N2K1-2
REFSEQ proteins (4 alternative transcripts):
NP_477515.2 NP_919296.1 NP_919439.1 NP_919440.1 ENSEMBL proteins: ENSP00000342541 ENSP00000305826 ENSP00000353653 ENSP00000340197 ENSP00000383719 ENSP00000383718 ENSP00000344857 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for UBE2J2: Assays for UBE2J2:
Protein
Domains/ Families for UBE2J2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q8N2K1 ProtoNet protein and cluster: Q8N2K1
1 Blocks protein family : IPB000608 Ubiquitin-conjugating enzymes UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1 Similarity : Belongs to the ubiquitin-conjugating enzyme family
Gene Function for UBE2J2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_058167 Applied Biosystems Silencer ® siRNAs for UBE2J2 Sigma-Aldrich siRNA and siRNA Panels for UBE2J2 Sigma-Aldrich shRNA Panels and shRNA for UBE2J2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_058167                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_058167                                  untagged cDNA clones in CMV expression vector (see all 6 ): AF296658  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_194315 UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1 Function : Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function inthe selective degradation of misfolded membrane proteins from the endoplasmic reticulum (Bysimilarity) Catalytic activity : ATP + ubiquitin + protein lysine = AMP + diphosphate + proteinN-ubiquityllysine Enzyme Number (IUBMB): EC 6.3.2.19
1 MGI phenotypic allele for Ube2j2 (no phenotypes)2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004842 ubiquitin-protein ligase activity
IEA -- GO:0016874 ligase activity
IEA --
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Pathways & Interactions for UBE2J2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2J2 (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1 Pathway : Protein modification; protein ubiquitination
1 Interacting protein for UBE2J2 (ENSP00000305826 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0019941 modification-dependent protein catabolic process
IEA -- GO:0043687 post-translational protein modification
IEA -- GO:0051246 regulation of protein metabolic process
IEA --
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Drugs & Compounds for UBE2J2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for UBE2J2
Transcripts for UBE2J2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5 ): NM_058167 Sigma-Aldrich siRNA and siRNA Panels for UBE2J2 Sigma-Aldrich shRNA Panels and shRNA for UBE2J2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_058167 NM_194315 NM_194457 NM_194458
REFSEQ mRNAs for UBE2J2 gene (4 alternative transcripts): NM_058167.2 NM_194315.1 NM_194457.1 NM_194458.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_058167 NM_194315 NM_194457 NM_194458
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4 ): NM_058167                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 4 ): NM_058167                                  untagged cDNA clones in CMV expression vector (see all 6 ): AF296658  
Additional cDNA sequence: AF296658.1 AK056065.1 AK075017.1 AK098803.1 AK291935.1 BC027728.2 BC052579.1 BC094777.1 BC104890.1 BC113430.1 BC143657.1 CR590185.1 CR592102.1 CR598255.1 CR601173.1 CR605285.1 CR607169.1 CR610022.1 CR612438.1
19 DOTS entries : DT.100881363 DT.40283075 DT.100042059 DT.100881365 DT.419470 DT.425940 DT.95076950 DT.95193420 DT.121442457 DT.95076949 DT.97836722 DT.121442506 DT.100809540 DT.100881349 DT.121442490 DT.91915343 DT.95076884 DT.100881357 DT.95279782
24/358 AceView cDNA sequences (see all 358
):BG391351 CD365765 BG421662 CR612438 BM766032 BG397868 AI140287 BG110522 AW167553 BM765278 CB160932 AK098803 BM920381 AW404406 CK431124 NM_194457 CR598255 BF037192 BE262422 BM473968 AI784467 AF116687 BE775090 BM794599
highest scoring ESTs for UBE2J2 :AA314553 AA411279 AA442034 AI681334 AK075017 AL555293 BE382927 BE905217 BF035520 BF037192
Unigene Cluster for UBE2J2: Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) Hs.191987 [show with all ESTs ] Unigene Representative Sequence: NM_194458 GeneLoc Exon Structure 5/27 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J2 (see all 27
) ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · SP1 :     -   -   -   -   -       -   -   -   -     -   -   -   -         -   -         SP2 :     -   -   -   -   -       -   -   -       -   -   -   -         -   -         SP3 :           -   -       -   -   -   -     -   -   -   -         -   -         SP4 :                   -   -   -       -   -   -   -         -   -         SP5 :                   -   -   -   -     -     -   -         -   -        
ExUns: 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k · 12l SP1 :                     SP2 :                     SP3 :                     SP4 :                     SP5 :                    
About this scheme ECgene alternative splicing isoforms for UBE2J2 7 Ensembl transcripts including schematic representations : ENST00000348298
ENST00000349431
ENST00000360466
ENST00000339385
ENST00000400930
ENST00000400929
ENST00000347370
Expression for UBE2J2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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UBE2J2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for UBE2J2 1 / 2 / 3
7 probe-sets matching UBE2J2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CGCCGGGGGCSOURCE GeneReport for Unigene cluster: Hs.191987
Orthologs for UBE2J2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for UBE2J2 gene from 5/16 species (see all 16
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
UBE2J21
--
ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, more
89.58(n) 95.75(a)
606935 XM_843241.1 XP_848334.1
cow (Bos taurus)
UBE2J21
--
ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, more
89.7(n) 95.37(a)
506103 NM_001038043.1 NP_001033132.1
rat (Rattus norvegicus)
Ube2j21
--
ubiquitin-conjugating enzyme E2, J2
86.49(n) 94.98(a)
298689 NM_001007655.1 NP_001007656.1
mouse (Mus musculus)
Ube2j21 , 5
4 (83.00 cM) 5
ubiquitin-conjugating enzyme E2, J2 homolog (yeast)1, 5
86.87(n) 1 94.21(a) 1
140499 1 NM_001039157.1 1 NP_001034246.1 1 AA545221 5 AF296656 5 (see all 21 )
chicken (Gallus gallus)
UBE2J21
--
ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, more
79.92(n) 91.51(a)
419421 XM_001233676.1 XP_001233677.1
About this table Species with no ortholog for UBE2J2 ENSEMBL Gene Tree for UBE2J2 Paralogs for UBE2J2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for UBE2J2 gene UBE2J1 2
SNPs/Variants for UBE2J2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for UBE2J2 (up to first 250kb)
Disorders & Mutations for UBE2J2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for UBE2J2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for UBE2J2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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7 PubMed articles for UBE2J2 gene :
Search for UBE2J2
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing UBE2J2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing UBE2J2
(According to HUGE )
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Specialized Databases showing UBE2J2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for UBE2J2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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