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Aliases for UBE2J2 Gene

Aliases for UBE2J2 Gene

  • Ubiquitin-Conjugating Enzyme E2, J2 2 3
  • Ubiquitin-Conjugating Enzyme E2, J2 (UBC6 Homolog, Yeast) 2 3
  • Non-Canonical Ubiquitin-Conjugating Enzyme 2 3 4
  • EC 6.3.2.19 4 64
  • NCUBE-2 3 4
  • NCUBE2 3 4
  • Ubiquitin Conjugating Enzyme E2, J2 3
  • Ubiquitin-Conjugating Enzyme E2 J2 3
  • Ubiquitin Conjugating Enzyme 6 3
  • Yeast UBC6 Homolog 3
  • PRO2121 3

External Ids for UBE2J2 Gene

Summaries for UBE2J2 Gene

Entrez Gene Summary for UBE2J2 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2J2 Gene

UBE2J2 (Ubiquitin-Conjugating Enzyme E2, J2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2J1.

UniProtKB/Swiss-Prot for UBE2J2 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2J2 Gene

Genomics for UBE2J2 Gene

Genomic Location for UBE2J2 Gene

Start:
1,253,909 bp from pter
End:
1,273,885 bp from pter
Size:
19,977 bases
Orientation:
Minus strand

Genomic View for UBE2J2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2J2 Gene

Regulatory Elements for UBE2J2 Gene

Proteins for UBE2J2 Gene

  • Protein details for UBE2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2K1-UB2J2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 J2
    Protein Accession:
    Q8N2K1
    Secondary Accessions:
    • A8MYC7
    • Q504T9
    • Q96N26
    • Q96T84

    Protein attributes for UBE2J2 Gene

    Size:
    259 amino acids
    Molecular mass:
    28898 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BM544827; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BM544827; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2J2 Gene

    Alternative splice isoforms for UBE2J2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2J2 Gene

Proteomics data for UBE2J2 Gene at MOPED

Selected DME Specific Peptides for UBE2J2 Gene

Post-translational modifications for UBE2J2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys64

Domains for UBE2J2 Gene

Gene Families for UBE2J2 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2J2 Gene

UniProtKB/Swiss-Prot:

UB2J2_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • Q8N2K1
genes like me logo Genes that share domains with UBE2J2: view

Function for UBE2J2 Gene

Molecular function for UBE2J2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity).

Enzyme Numbers (IUBMB) for UBE2J2 Gene

Gene Ontology (GO) - Molecular Function for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with UBE2J2: view

Phenotypes for UBE2J2 Gene

GenomeRNAi human phenotypes for UBE2J2:
genes like me logo Genes that share phenotypes with UBE2J2: view

miRNA for UBE2J2 Gene

miRTarBase miRNAs that target UBE2J2

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2J2 Gene

Localization for UBE2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2J2 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2J2 Gene COMPARTMENTS Subcellular localization image for UBE2J2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UBE2J2: view

Pathways for UBE2J2 Gene

genes like me logo Genes that share pathways with UBE2J2: view

UniProtKB/Swiss-Prot Q8N2K1-UB2J2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006986 response to unfolded protein IEA --
GO:0008152 metabolic process --
GO:0016567 protein ubiquitination --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IBA --
genes like me logo Genes that share ontologies with UBE2J2: view

Compounds for UBE2J2 Gene

(4) HMDB Compounds for UBE2J2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2J2: view

Transcripts for UBE2J2 Gene

Unigene Clusters for UBE2J2 Gene

Ubiquitin-conjugating enzyme E2, J2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - -
SP19: - - - - - - - - -
SP20: - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - -
SP23: - -
SP24: - - - - - - - - -
SP25:
SP26: -
SP27:

ExUns: 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k · 12l
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for UBE2J2 Gene

GeneLoc Exon Structure for
UBE2J2
ECgene alternative splicing isoforms for
UBE2J2

Expression for UBE2J2 Gene

mRNA expression in normal human tissues for UBE2J2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2J2 Gene

SOURCE GeneReport for Unigene cluster for UBE2J2 Gene Hs.191987

genes like me logo Genes that share expressions with UBE2J2: view

Orthologs for UBE2J2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2J2 36
  • 94.49 (n)
  • 92.91 (a)
cow
(Bos Taurus)
Mammalia UBE2J2 36
  • 89.7 (n)
  • 95.37 (a)
UBE2J2 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2J2 36
  • 89.58 (n)
  • 95.75 (a)
UBE2J2 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2j2 36
  • 86.87 (n)
  • 94.21 (a)
Ube2j2 16
Ube2j2 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2J2 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2J2 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2j2 36
  • 86.49 (n)
  • 94.98 (a)
chicken
(Gallus gallus)
Aves UBE2J2 36
  • 79.92 (n)
  • 91.51 (a)
UBE2J2 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2J2 37
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5968 36
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2j2 36
  • 76.45 (n)
  • 90.35 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2j2 36
  • 74.77 (n)
  • 88.03 (a)
ube2j2 37
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005954 36
  • 55.51 (n)
  • 60.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5823 36
  • 55.94 (n)
  • 57.36 (a)
CG5823 37
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ubc-15 37
  • 41 (a)
OneToMany
ubc-26 36
  • 61.74 (n)
  • 60.95 (a)
ubc-26 37
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR372W 36
  • 51.72 (n)
  • 45.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC6 36
  • 57.59 (n)
  • 58.86 (a)
UBC6 37
  • 41 (a)
OneToMany
UBC6 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20395g 36
  • 55.41 (n)
  • 56.69 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC34 36
  • 55.22 (n)
  • 53.01 (a)
rice
(Oryza sativa)
Liliopsida Os06g0193000 36
  • 52.75 (n)
  • 48.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc6 36
  • 55.41 (n)
  • 54.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 63 (a)
OneToOne
Species with no ortholog for UBE2J2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2J2 Gene

ENSEMBL:
Gene Tree for UBE2J2 (if available)
TreeFam:
Gene Tree for UBE2J2 (if available)

Paralogs for UBE2J2 Gene

Paralogs for UBE2J2 Gene

genes like me logo Genes that share paralogs with UBE2J2: view

Variants for UBE2J2 Gene

Sequence variations from dbSNP and Humsavar for UBE2J2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs912852 -- 1,271,119(+) CCAGC(A/G)GGTTC intron-variant
rs1058146 -- 1,255,275(-) AACTT(G/T)TTTGT reference, missense
rs1058161 -- 1,255,143(-) ACCTC(A/G)GCAGG utr-variant-3-prime
rs3818646 -- 1,256,490(+) AAGAC(C/T)GAGAG intron-variant
rs3829743 -- 1,255,365(+) TGCCC(A/G)TTGAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UBE2J2 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871107 CNV Loss 21882294
dgv23n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
dgv26n71 CNV Loss 21882294
nsv455661 CNV Loss 19166990
nsv871327 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
nsv871965 CNV Loss 21882294
nsv817616 CNV Loss 17921354
dgv28n71 CNV Gain 21882294
dgv8e1 CNV Complex 17122850
dgv29n71 CNV Loss 21882294
esv2745807 CNV Deletion 23290073
nsv870963 CNV Loss 21882294

Relevant External Links for UBE2J2 Gene

HapMap Linkage Disequilibrium report
UBE2J2

Disorders for UBE2J2 Gene

Relevant External Links for UBE2J2

Genetic Association Database (GAD)
UBE2J2
genes like me logo Genes that share disorders with UBE2J2: view

No data available for UniProtKB/Swiss-Prot for UBE2J2 Gene

Publications for UBE2J2 Gene

  1. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). (PMID: 11278356) Tiwari S. … Weissman A.M. (J. Biol. Chem. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 3
  5. Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress. (PMID: 16720581) Oh R.S. … Rommens J.M. (J. Biol. Chem. 2006) 3

Products for UBE2J2 Gene

Sources for UBE2J2 Gene

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