Aliases for UBE2J2 Gene
External Ids for UBE2J2 Gene
Previous GeneCards Identifiers for UBE2J2 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2J2 Gene
UBE2J2 (Ubiquitin Conjugating Enzyme E2 J2) is a Protein Coding gene. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Innate Immune System. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2J1.
UniProtKB/Swiss-Prot for UBE2J2 Gene
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).