Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UBE2J2 Gene

protein-coding   GIFtS: 62
GCID: GC01M001189

Ubiquitin-Conjugating Enzyme E2, J2

(Previous names: ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast))
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin-Conjugating Enzyme E2, J21 2     PRO21212
Ubiquitin-Conjugating Enzyme E2, J2 (UBC6 Homolog, Yeast)1 2     Ubiquitin Conjugating Enzyme 62
Non-Canonical Ubiquitin-Conjugating Enzyme 22 3     Ubiquitin Conjugating Enzyme E2, J22
NCUBE-22 3     Ubiquitin-Conjugating Enzyme E2 J22
NCUBE22 3     Yeast UBC6 Homolog2
EC 6.3.2.193 8     

External Ids:    HGNC: 192681   Entrez Gene: 1184242   Ensembl: ENSG000001600877   UniProtKB: Q8N2K13   

Export aliases for UBE2J2 gene to outside databases

Previous GC identifers: GC01M000941 GC01M001066 GC01M001095 GC01M001229 GC01M001182 GC01M000461


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for UBE2J2 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the
membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for
this gene, but the full-length nature of some variants has not been defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2J2 Gene:
UBE2J2 (ubiquitin-conjugating enzyme E2, J2) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2J1.

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective
degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2J2 gene promoter:
         AhR   NF-1   LCR-F1   Tal-1beta   Roaz   N-Myc   CP2   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2J2 promoter sequence
   Search Chromatin IP Primers for UBE2J2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2J2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

UBE2J2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2J2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001189:  view genomic region     (about GC identifiers)

Start:
1,189,289 bp from pter      End:
1,209,265 bp from pter
Size:
19,977 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 J2  
Size: 259 amino acids; 28898 Da
Sequence caution: Sequence=BM544827; Type=Frameshift; Positions=Several; Sequence=BM544827; Type=Miscellaneous
discrepancy;
1 PDB 3D structure from and Proteopedia for UBE2J2:
2F4W (3D)    
Secondary accessions: A8MYC7 Q504T9 Q96N26 Q96T84
Alternative splicing: 3 isoforms:  Q8N2K1-1   Q8N2K1-2   Q8N2K1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2J2: NX_Q8N2K1

Explore proteomics data for UBE2J2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys64
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for UBE2J2 (Q8N2K1)
     NTRLCLS  HPDTWNP  WNPAWSV  NILEWHYV 


    See UBE2J2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_477515.2  NP_919296.1  NP_919439.1  NP_919440.1  

    ENSEMBL proteins: 
     ENSP00000407565   ENSP00000305826   ENSP00000383718   ENSP00000423880   ENSP00000353653  
     ENSP00000383719   ENSP00000427024   ENSP00000393301   ENSP00000425419   ENSP00000422103  
     ENSP00000425543   ENSP00000423480   ENSP00000401898   ENSP00000424342   ENSP00000427244  
     ENSP00000340197   ENSP00000344857   ENSP00000342541  
    Reactome Protein details: Q8N2K1

    UBE2J2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UBE2J2
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UBE2J2
    OriGene Protein Over-expression Lysate for UBE2J2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UBE2J2
    GenScript Custom Purified and Recombinant Proteins Services for UBE2J2
    Novus Biologicals UBE2J2 Proteins
    Novus Biologicals UBE2J2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBE2J2
    Cloud-Clone Corp. Proteins for UBE2J2

     
    Search eBioscience for Proteins for UBE2J2 

    UBE2J2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UBE2J2
    OriGene Custom Antibody Services for UBE2J2
    Novus Biologicals UBE2J2 Antibodies
    Abcam antibodies for UBE2J2
    Cloud-Clone Corp. Antibodies for UBE2J2
    Search ThermoFisher Antibodies for UBE2J2
    LSBio Antibodies in human, mouse, rat for UBE2J2

    UBE2J2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBE2J2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBE2J2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBE2J2
    Cloud-Clone Corp. CLIAs for UBE2J2
    Search eBioscience for ELISAs for UBE2J2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q8N2K1

    ProtoNet protein and cluster: Q8N2K1

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2J2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2J2_HUMAN, Q8N2K1
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective
    degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with UBE2J2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for UBE2J2:
     Cell cycle / mitosis defect  Increased cell death in HCT116 

         1 MGI phenotypic allele for Ube2j2 (no phenotypes)

    Find genes that share phenotypes with UBE2J2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2J2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2J2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2J2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2J2

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2J2:
    hsa-mir-423-3p (MIRT042648), hsa-mir-1301-3p (MIRT036006), hsa-mir-155-5p (MIRT020523)

    Block miRNA regulation of human, mouse, rat UBE2J2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UBE2J2:
    hsa-miR-3163 hsa-miR-299-5p hsa-miR-659 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidUBE2J2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBE2J2
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2J2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBE2J2

    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2J2 (see all 21)
    OriGene ORF clones in mouse, rat for UBE2J2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): UBE2J2 (NM_058167)
    Sino Biological Human cDNA Clone for UBE2J2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2J2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2J2
    Addgene plasmids for UBE2J2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBE2J2
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBE2J2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UB2J2_HUMAN, Q8N2K1: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UBE2J2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UBE2J2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    4Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    5Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions


    Find genes that share SuperPaths with UBE2J2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2J2
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for UBE2J2
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 BioSystems Pathways for UBE2J2
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway


    1 Reactome Pathway for UBE2J2
        Antigen processing: Ubiquitination & Proteasome degradation


    3 Kegg Pathways  (Kegg details for UBE2J2):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2J2: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBE2J2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2J2 (Q8N2K13 ENSP000003837194) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2G2P606043, ENSP000003383484I2D: score=2 STRING: ENSP00000338348
    ICMTO607253, ENSP000003435524I2D: score=1 STRING: ENSP00000343552
    MGRN1O602913, ENSP000002623704I2D: score=1 STRING: ENSP00000262370
    PDE4DIPQ5VU433, ENSP000003583604I2D: score=1 STRING: ENSP00000358360
    TRIM25Q142583, ENSP000003238894I2D: score=1 STRING: ENSP00000323889
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006986response to unfolded protein IEA--

    Find genes that share ontologies with UBE2J2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2J2 (UB2J2)

    4 HMDB Compounds for UBE2J2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UBE2J2 gene (5 alternative transcripts): 
    NM_058167.2  NM_194315.1  NM_194457.1  NM_194458.1  NM_194316.1  

    Unigene Cluster for UBE2J2:

    Ubiquitin-conjugating enzyme E2, J2
    Hs.191987  [show with all ESTs]
    Unigene Representative Sequence: NM_194458
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000450390(uc001adm.3 uc001ado.3 uc001adp.3 uc001adr.3)
    ENST00000349431 ENST00000400929 ENST00000464036 ENST00000360466 ENST00000400930
    ENST00000467339 ENST00000473215 ENST00000435198 ENST00000509720 ENST00000491779
    ENST00000466752 ENST00000503294 ENST00000477894 ENST00000471154 ENST00000422076
    ENST00000502382 ENST00000461142
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBE2J2 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate UBE2J2:
    hsa-miR-3163 hsa-miR-299-5p hsa-miR-659 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidUBE2J2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBE2J2
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2J2
    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2J2 (see all 21)
    OriGene ORF clones in mouse, rat for UBE2J2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): UBE2J2 (NM_058167)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2J2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2J2
    Addgene plasmids for UBE2J2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBE2J2
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2J2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2J2
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2J2
      QuantiFast Probe-based Assays in human, mouse, rat UBE2J2

    Additional mRNA sequence: 

    AF296658.1 AK056065.1 AK075017.1 AK098803.1 AK291935.1 BC027728.2 BC052579.1 BC094777.1 
    BC104890.1 BC113430.1 BC143657.1 

    19 DOTS entries:

    DT.100881363  DT.40283075  DT.100042059  DT.100881365  DT.425940  DT.419470  DT.95076950  DT.95193420 
    DT.121442457  DT.95076949  DT.97836722  DT.121442506  DT.100809540  DT.100881349  DT.121442490  DT.91915343 
    DT.95076884  DT.100881357  DT.95279782 

    Selected AceView cDNA sequences (see all 358):

    AI250944 CD672671 BG106735 BF476166 CR612438 AI492148 BM473968 AA353405 
    BE775069 BM794599 AA845898 NM_194457 CR590185 AI440313 BM745282 CD671697 
    BM770137 BM931427 BM765800 BC027728 AW167553 AI283828 NM_194315 CB529058 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J2 (see all 27)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
    SP1:              -     -     -     -     -                 -     -     -     -           -     -     -     -                       -     -                     
    SP2:              -     -     -     -     -                 -     -     -                 -     -     -     -                       -     -                     
    SP3:                                -     -                 -     -     -     -           -     -     -     -                       -     -                     
    SP4:                                                        -     -     -                 -     -     -     -                       -     -                     
    SP5:                                                        -     -     -     -           -           -     -                       -     -                     

    ExUns: 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k · 12l
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for UBE2J2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UBE2J2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCGGGGGC
    UBE2J2 Expression
    About this image

    UBE2J2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2J2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191987
        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2J2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2J2
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2J2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2J2
    QuantiTect SYBR Green Assays in human, mouse, rat UBE2J2
    QuantiFast Probe-based Assays in human, mouse, rat UBE2J2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2J2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2j21 , 5 ubiquitin-conjugating enzyme E2, J2 homolog (yeast)5
    ubiquitin-conjugating enzyme E2J 21
    86.87(n)1
    94.21(a)1
      4 (87.66 cM)5
    1404991  NM_001039157.21  NP_001034246.11 
     1559438315 
    chicken
    (Gallus gallus)
    Aves UBE2J21 ubiquitin-conjugating enzyme E2, J2 79.92(n)
    91.51(a)
      419421  XM_417582.3  XP_417582.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2J26
    ubiquitin-conjugating enzyme E2, J2
    90(a)
    1 ↔ 1
    GL344341.1(27277-33511)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59682 Xenopus laevis transcribed sequence with moderate similarity more 79.49(n)    BX848004.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2j21 ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, more 74.77(n)
    88.03(a)
      100037384  NM_001089535.1  NP_001083004.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58231 CG5823 55.94(n)
    57.36(a)
      42105  NM_142374.3  NP_650631.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-261 ubc-26 61.74(n)
    60.95(a)
      259424  NM_182122.3  NP_871922.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC6(YER100W)4
    UBC61
    Ubiquitin-conjugating enzyme involved in ER-associated more4
    UBC61
    57.59(n)1
    58.86(a)1
      5(359562-360314)4
    8568371, 4  NP_011026.31  NP_011026.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC341 UBC34 55.22(n)
    53.01(a)
      838300  NM_001084085.1  NP_001077554.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01930001 Os06g0193000 52.75(n)
    48.06(a)
      4340379  NM_001063575.1  NP_001057040.1 


    ENSEMBL Gene Tree for UBE2J2 (if available)
    TreeFam Gene Tree for UBE2J2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UBE2J2 gene
    UBE2J12  
    9 SIMAP similar genes for UBE2J2 using alignment to 10 protein entries:     UB2J2_HUMAN (see all proteins):
    UBE2J1    UBE2DNL    UBE2A    UBE2D3    UBE2D2    UBE2D1
    UBE2N    UBE2D4    UBE2B

    Find genes that share paralogs with UBE2J2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UBE2J2 (see all 518)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127432871,2
    C,F--1188944(+) GATTAT/GAGGCG 4 -- ds50012Minor allele frequency- G:0.04CSA WA 120
    rs1507078581,2
    C--1188949(+) TAGGCA/GGCAGC 4 -- ds50010--------
    rs1379102841,2
    --1188965(+) CACCCA/GGCAGT 4 -- ds50010--------
    rs121205411,2
    C,H--1188995(+) CTATTC/AGTTAG 4 -- ds50016Minor allele frequency- A:0.00NS EA NA 424
    rs1494703321,2
    --1189022(+) AGCCTC/GGGGAG 4 -- ds50010--------
    rs1158967101,2
    C,F--1189054(+) GCTGGC/TGGTCA 4 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1153288201,2
    F--1189199(+) CAGGCC/TAGCAG 4 -- ds50011Minor allele frequency- T:0.01NA 120
    rs2017789281,2
    --1189319(+) AGACC-/TTTTTT 4 -- ut310--------
    rs1865804841,2
    --1189327(+) TTTTTC/TCCACA 4 -- ut310--------
    rs1473235081,2
    C--1189359(+) ATTGGC/TAAATT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2J2 (1189289 - 1209265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UBE2J2 (see all 34):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745807CNV Deletion23290073
    nsv470680CNV Loss18288195
    dgv29n71CNV Loss21882294
    nsv482937CNV Loss15286789
    dgv12n71CNV Loss21882294
    dgv25n71CNV Loss21882294
    dgv21n71CNV Loss21882294
    nsv871965CNV Loss21882294
    dgv26n71CNV Loss21882294
    dgv11n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2J2
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2J2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus

    Find genes that share disorders with UBE2J2           About GenesLikeMe

    Genetic Association Database (GAD): UBE2J2

    Export disorders for UBE2J2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UBE2J2 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with UBE2J2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). (PubMed id 11278356)1, 2, 3 Tiwari S. and Weissman A.M. (J. Biol. Chem. 2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Identification of novel ATP13A2 interactors and their role in I+-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (Hum. Mol. Genet. 2012)
    4. A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen. (PubMed id 22496338)1 Sheng Y....Dhe-Paganon S. (amp 2012)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    9. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PubMed id 20061386)1 David Y.... Navon A. (J. Biol. Chem. 2010)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 118424 HGNC: 19268 AceView: UBE2J2 Ensembl:ENSG00000160087 euGenes: HUgn118424
    ECgene: UBE2J2 Kegg: 118424 H-InvDB: UBE2J2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UBE2J2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UBE2J2 gene:
    Search GeneIP for patents involving UBE2J2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for UBE2J2 (UBE2J2)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBE2J2   OriGene RNAi products in human, mouse, rat for UBE2J2  
     OriGene qPCR primer pairs and template standards for UBE2J2   OriGene Protein Over-expression Lysate for UBE2J2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UBE2J2  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBE2J2   OriGene Purified Protein for UBE2J2  
     OriGene ORF clones in mouse, rat for UBE2J2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBE2J2   OriGene Custom Protein Services for UBE2J2  

     
     
     Block miRNA regulation of human, mouse, rat UBE2J2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UBE2J2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2J2 Predesigned siRNA for gene silencing in human, mouse, rat UBE2J2
     QuantiFast Probe-based Assays in human, mouse, rat UBE2J2 QuantiTect SYBR Green Assays in human, mouse, rat UBE2J2
     PCR Arrays including human, mouse, rat UBE2J2 Search Chromatin IP Primers for UBE2J2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2J2  Search GeneGlobe Interaction Network for UBE2J2
     Regulatory tfbs in UBE2J2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for UBE2J2 GenScript cDNA clones with any tag delivered in your preferred vector for UBE2J2
     GenScript Custom Assay Services for UBE2J2 GenScript Custom overexpressing Cell Line Services for UBE2J2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for UBE2J2 (UB2J2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for UBE2J2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UBE2J2 antibodies
     UBE2J2 proteins
     UBE2J2 lysates
     Antibodies for UBE2J2
     See all of Abcam's Antibodies, Kits and Proteins for UBE2J2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UBE2J2
     Proteins for UBE2J2
     Antibodies for UBE2J2
     ELISAs for UBE2J2
     CLIAs for UBE2J2



     Browse ESI BIO Cell Lines and PureStem Progenitors for UBE2J2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J2
     SwitchGear 3'UTR luciferase reporter plasmids for UBE2J2
     SwitchGear Promoter luciferase reporter plasmids for UBE2J2
     Search ThermoFisher Antibodies for UBE2J2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2J2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2J2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2J2
     LSBio Antibodies in human, mouse, rat for UBE2J2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for UBE2J2
      Search eBioscience for proteins for UBE2J2
      Search eBioscience for elisas for UBE2J2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBE2J2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4