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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2J2 Gene

protein-coding   GIFtS: 61
GCID: GC01M001182

Ubiquitin-Conjugating Enzyme E2, J2

(Previous names: ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2, J21 2     PRO21212
Ubiquitin-Conjugating Enzyme E2, J2 (UBC6 Homolog, Yeast)1 2     Ubiquitin Conjugating Enzyme 62
Non-Canonical Ubiquitin-Conjugating Enzyme 22 3     Ubiquitin Conjugating Enzyme E2, J22
NCUBE-22 3     Ubiquitin-Conjugating Enzyme E2 J22
NCUBE22 3     Yeast UBC6 Homolog2
EC 6.3.2.193 8     

External Ids:    HGNC: 192681   Entrez Gene: 1184242   Ensembl: ENSG000001600877   UniProtKB: Q8N2K13   

Export aliases for UBE2J2 gene to outside databases

Previous GC identifers: GC01M000941 GC01M001066 GC01M001095 GC01M001229 GC01M000461


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2J2 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the
membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for
this gene, but the full-length nature of some variants has not been defined. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2J2 Gene: 
UBE2J2 (ubiquitin-conjugating enzyme E2, J2) is a protein-coding gene. Diseases associated with UBE2J2 include parkinson's disease, and gastric cancer, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is UBE2J1.

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective
degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2J2 gene promoter:
         AhR   NF-1   LCR-F1   Tal-1beta   Roaz   N-Myc   CP2   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2J2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2J2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2J2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33   Ensembl cytogenetic band:  1p36.33   HGNC cytogenetic band: 1p36.33

UBE2J2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2J2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M001182:  view genomic region     (about GC identifiers)

Start:
1,189,289 bp from pter      End:
1,209,265 bp from pter
Size:
19,977 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 J2  
Size: 259 amino acids; 28898 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity)
Sequence caution: Sequence=BM544827; Type=Frameshift; Positions=Several; Sequence=BM544827; Type=Miscellaneous
discrepancy;
1 PDB 3D structure from and Proteopedia for UBE2J2:
2F4W (3D)    
Secondary accessions: A8MYC7 Q504T9 Q96N26 Q96T84
Alternative splicing: 3 isoforms:  Q8N2K1-1   Q8N2K1-2   Q8N2K1-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2J2: NX_Q8N2K1

Explore proteomics data for UBE2J2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N2K1

  • 4 DME Specific Peptides for UBE2J2 (Q8N2K1)
     NTRLCLS  HPDTWNP  WNPAWSV  NILEWHYV 

    UBE2J2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2J2 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_477515.2  NP_919296.1  NP_919439.1  NP_919440.1  

    ENSEMBL proteins: 
     ENSP00000407565   ENSP00000305826   ENSP00000383718   ENSP00000423880   ENSP00000353653  
     ENSP00000383719   ENSP00000427024   ENSP00000393301   ENSP00000425419   ENSP00000422103  
     ENSP00000425543   ENSP00000423480   ENSP00000401898   ENSP00000424342   ENSP00000427244  
     ENSP00000340197   ENSP00000344857   ENSP00000342541  
    Reactome Protein details: Q8N2K1
    Human Recombinant Protein Products for UBE2J2: 
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    Novus Biologicals UBE2J2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UBE2J2
    Cloud-Clone Corp. Proteins for UBE2J2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    UBE2J2 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for UBE2J2 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q8N2K1

    ProtoNet protein and cluster: Q8N2K1

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2J2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2J2_HUMAN, Q8N2K1
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective
    degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2J2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for UBE2J2:
     Cell cycle / mitosis defect  Increased cell death in HCT116 

         1 MGI phenotypic allele for Ube2j2 (no phenotypes)

    UBE2J2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2J2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2J2 
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    hsa-miR-3163 hsa-miR-299-5p hsa-miR-659 hsa-miR-3662
    SwitchGear 3'UTR luciferase reporter plasmidUBE2J2 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2J2 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.61
    5Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UBE2J2
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2J2
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for UBE2J2
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 BioSystems Pathways for UBE2J2
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway


    4        Reactome Pathways for UBE2J2
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    3         Kegg Pathways  (Kegg details for UBE2J2):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1
    Pathway: Protein modification; protein ubiquitination


    UBE2J2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2J2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/36 Interacting proteins for UBE2J2 (Q8N2K13 ENSP000003837194) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2G2P606043, ENSP000003383484I2D: score=2 STRING: ENSP00000338348
    ICMTO607253, ENSP000003435524I2D: score=1 STRING: ENSP00000343552
    MGRN1O602913, ENSP000002623704I2D: score=1 STRING: ENSP00000262370
    PDE4DIPQ5VU433, ENSP000003583604I2D: score=1 STRING: ENSP00000358360
    TRIM25Q142583, ENSP000003238894I2D: score=1 STRING: ENSP00000323889
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006986response to unfolded protein IEA--

    UBE2J2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2J2 (UB2J2)

    4 HMDB Compounds for UBE2J2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2J2 / UB2J2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2J2 gene (5 alternative transcripts): 
    NM_058167.2  NM_194315.1  NM_194457.1  NM_194458.1  NM_194316.1  

    Unigene Cluster for UBE2J2:

    Ubiquitin-conjugating enzyme E2, J2
    Hs.191987  [show with all ESTs]
    Unigene Representative Sequence: NM_194458
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000450390(uc001adm.3 uc001ado.3 uc001adp.3 uc001adr.3)
    ENST00000349431 ENST00000400929 ENST00000464036 ENST00000360466 ENST00000400930
    ENST00000467339 ENST00000473215 ENST00000435198 ENST00000509720 ENST00000491779
    ENST00000466752 ENST00000503294 ENST00000477894 ENST00000471154 ENST00000422076
    ENST00000502382 ENST00000461142

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    Additional mRNA sequence: 

    AF296658.1 AK056065.1 AK075017.1 AK098803.1 AK291935.1 BC027728.2 BC052579.1 BC094777.1 
    BC104890.1 BC113430.1 BC143657.1 

    19 DOTS entries:

    DT.100881363  DT.40283075  DT.100042059  DT.100881365  DT.425940  DT.419470  DT.95076950  DT.95193420 
    DT.121442457  DT.95076949  DT.97836722  DT.121442506  DT.100809540  DT.100881349  DT.121442490  DT.91915343 
    DT.95076884  DT.100881357  DT.95279782 

    24/358 AceView cDNA sequences (see all 358):

    BQ690309 BM772182 BG112933 AI440313 CD672671 BM765278 AI369622 BF476166 
    BE775069 BU737307 AI250944 AI492148 BF037192 AK125883 CR590185 AI784467 
    BM766232 CK431124 AA845898 CB529058 BM765800 BM458668 CR598255 BM931427 

    GeneLoc Exon Structure

    5/27 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J2 (see all 27)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
    SP1:              -     -     -     -     -                 -     -     -     -           -     -     -     -                       -     -                     
    SP2:              -     -     -     -     -                 -     -     -                 -     -     -     -                       -     -                     
    SP3:                                -     -                 -     -     -     -           -     -     -     -                       -     -                     
    SP4:                                                        -     -     -                 -     -     -     -                       -     -                     
    SP5:                                                        -     -     -     -           -           -     -                       -     -                     

    ExUns: 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k · 12l
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for UBE2J2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2J2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCCGGGGGC
    UBE2J2 Expression
    About this image


    See UBE2J2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2J2

    SOURCE GeneReport for Unigene cluster: Hs.191987
        SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2J2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2J2 gene from 10/24 species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2j21 , 5 ubiquitin-conjugating enzyme E2, J2 homolog (yeast)5
    ubiquitin-conjugating enzyme E2J 21
    86.87(n)1
    94.21(a)1
      4 (87.66 cM)5
    1404991  NM_021402.51  NP_067377.41 
     1559438315 
    chicken
    (Gallus gallus)
    Aves UBE2J21 ubiquitin-conjugating enzyme E2, J2 79.92(n)
    91.51(a)
      419421  XM_001233676.1  XP_001233677.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2J26
    Uncharacterized protein
    87(a)
    1 ↔ 1
    GL344341.1(27277-33511)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.59682 Xenopus laevis transcribed sequence with moderate similarity more 79.49(n)    BX848004.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2j21 ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, more 74.77(n)
    88.03(a)
      100037384  NM_001089535.1  NP_001083004.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG58231 CG5823 55.43(n)
    56.98(a)
      42105  NM_142374.2  NP_650631.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-261 Protein UBC-26 61.74(n)
    60.95(a)
      259424  NM_182122.2  NP_871922.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC6(YER100W)4
    UBC61
    Ubiquitin-conjugating enzyme involved in ER-associated more4
    Ubc6p1
    57.59(n)1
    58.86(a)1
      5(359562-360314)4
    8568371, 4  NP_011026.31  NP_011026.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC341 ubiquitin-conjugating enzyme E2 34 55.22(n)
    53.01(a)
      838300  NM_001084085.1  NP_001077554.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g01930001 hypothetical protein 55.3(n)
    52.27(a)
      4340379  NM_001063575.1  NP_001057040.1 


    ENSEMBL Gene Tree for UBE2J2 (if available)
    TreeFam Gene Tree for UBE2J2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2J2 gene
    UBE2J12  
    9 SIMAP similar genes for UBE2J2 using alignment to 10 protein entries:     UB2J2_HUMAN (see all proteins):
    UBE2J1    UBE2DNL    UBE2A    UBE2D3    UBE2D2    UBE2D1
    UBE2N    UBE2D4    UBE2B

    UBE2J2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/518 SNPs in UBE2J2 are shown (see all 518)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1127432871,2
    C,F--1188944(+) GATTAT/GAGGCG 4 -- ds50012Minor allele frequency- G:0.04CSA WA 120
    rs1507078581,2
    C--1188949(+) TAGGCA/GGCAGC 4 -- ds50010--------
    rs1379102841,2
    --1188965(+) CACCCA/GGCAGT 4 -- ds50010--------
    rs121205411,2
    C,H--1188995(+) CTATTC/AGTTAG 4 -- ds50016Minor allele frequency- A:0.00NS EA NA 424
    rs1494703321,2
    --1189022(+) AGCCTC/GGGGAG 4 -- ds50010--------
    rs1158967101,2
    C,F--1189054(+) GCTGGC/TGGTCA 4 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1153288201,2
    F--1189199(+) CAGGCC/TAGCAG 4 -- ds50011Minor allele frequency- T:0.01NA 120
    rs2017789281,2
    --1189319(+) AGACC-/TTTTTT 4 -- ut310--------
    rs1865804841,2
    --1189327(+) TTTTTC/TCCACA 4 -- ut310--------
    rs1473235081,2
    C--1189359(+) ATTGGC/TAAATT 4 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2J2 (1189289 - 1209265 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/34 variations for UBE2J2 (see all 34):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745807CNV Deletion23290073
    nsv470680CNV Loss18288195
    dgv29n71CNV Loss21882294
    nsv482937CNV Loss15286789
    dgv12n71CNV Loss21882294
    dgv25n71CNV Loss21882294
    dgv21n71CNV Loss21882294
    nsv871965CNV Loss21882294
    dgv26n71CNV Loss21882294
    dgv11n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for UBE2J2:    About MalaCards
    parkinson's disease    gastric cancer


    UBE2J2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): UBE2J2

    Export disorders for UBE2J2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2J2 gene, integrated from 9 sources (see all 18):
    (articles sorted by number of sources associating them with UBE2J2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). (PubMed id 11278356)1, 2, 3 Tiwari S. and Weissman A.M. (2001)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
    4. A human ubiquitin conjugating enzyme (E2)-HECT E3 liga se structure-function screen. (PubMed id 22496338)1 Sheng Y....Dhe-Paganon S. (2012)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    9. The E2 ubiquitin-conjugating enzymes direct polyubiqu itination to preferred lysines. (PubMed id 20061386)1 David Y....Navon A. (2010)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 118424 HGNC: 19268 AceView: UBE2J2 Ensembl:ENSG00000160087 euGenes: HUgn118424
    ECgene: UBE2J2 Kegg: 118424 H-InvDB: UBE2J2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2J2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2J2 gene:
    Search GeneIP for patents involving UBE2J2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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