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Aliases for UBE2J2 Gene

Aliases for UBE2J2 Gene

  • Ubiquitin Conjugating Enzyme E2 J2 2 3
  • Ubiquitin-Conjugating Enzyme E2, J2 (UBC6 Homolog, Yeast) 2 3
  • Non-Canonical Ubiquitin-Conjugating Enzyme 2 3 4
  • Ubiquitin Conjugating Enzyme E2, J2 3 5
  • E2 Ubiquitin-Conjugating Enzyme J2 3 4
  • NCUBE-2 3 4
  • NCUBE2 3 4
  • Ubiquitin-Conjugating Enzyme E2, J2 2
  • Ubiquitin Conjugating Enzyme 6 3
  • Yeast UBC6 Homolog 3
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • PRO2121 3

External Ids for UBE2J2 Gene

Previous GeneCards Identifiers for UBE2J2 Gene

  • GC01M000941
  • GC01M001066
  • GC01M001095
  • GC01M001229
  • GC01M001182
  • GC01M000461
  • GC01M001189

Summaries for UBE2J2 Gene

Entrez Gene Summary for UBE2J2 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2J2 Gene

UBE2J2 (Ubiquitin Conjugating Enzyme E2 J2) is a Protein Coding gene. Among its related pathways are Immune System and Remodeling of Adherens Junctions. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2J1.

UniProtKB/Swiss-Prot for UBE2J2 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2J2 Gene

Genomics for UBE2J2 Gene

Regulatory Elements for UBE2J2 Gene

Promoters for UBE2J2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2J2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2J2 Gene

Chromosome:
1
Start:
1,253,909 bp from pter
End:
1,273,885 bp from pter
Size:
19,977 bases
Orientation:
Minus strand

Genomic View for UBE2J2 Gene

Genes around UBE2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2J2 Gene

Proteins for UBE2J2 Gene

  • Protein details for UBE2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2K1-UB2J2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 J2
    Protein Accession:
    Q8N2K1
    Secondary Accessions:
    • A8MYC7
    • Q504T9
    • Q96N26
    • Q96T84

    Protein attributes for UBE2J2 Gene

    Size:
    259 amino acids
    Molecular mass:
    28898 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BM544827; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BM544827; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2J2 Gene

    Alternative splice isoforms for UBE2J2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2J2 Gene

Proteomics data for UBE2J2 Gene at MOPED

Selected DME Specific Peptides for UBE2J2 Gene

Post-translational modifications for UBE2J2 Gene

  • Ubiquitination at Lys 64
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for UBE2J2 Gene

Gene Families for UBE2J2 Gene

Protein Domains for UBE2J2 Gene

Suggested Antigen Peptide Sequences for UBE2J2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N2K1

UniProtKB/Swiss-Prot:

UB2J2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2J2: view

Function for UBE2J2 Gene

Molecular function for UBE2J2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Enzyme Numbers (IUBMB) for UBE2J2 Gene

Gene Ontology (GO) - Molecular Function for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031625 ubiquitin protein ligase binding IPI 24019521
genes like me logo Genes that share ontologies with UBE2J2: view
genes like me logo Genes that share phenotypes with UBE2J2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2J2

miRNA for UBE2J2 Gene

miRTarBase miRNAs that target UBE2J2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2J2 Gene

Localization for UBE2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2J2 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2J2 Gene COMPARTMENTS Subcellular localization image for UBE2J2 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IPI 24807418
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with UBE2J2: view

Pathways & Interactions for UBE2J2 Gene

genes like me logo Genes that share pathways with UBE2J2: view

UniProtKB/Swiss-Prot Q8N2K1-UB2J2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2J2 Gene

None

No data available for SIGNOR curated interactions for UBE2J2 Gene

Drugs & Compounds for UBE2J2 Gene

(3) Drugs for UBE2J2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2J2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2J2: view

Transcripts for UBE2J2 Gene

Unigene Clusters for UBE2J2 Gene

Ubiquitin-conjugating enzyme E2, J2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - -
SP19: - - - - - - - - -
SP20: - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - -
SP23: - -
SP24: - - - - - - - - -
SP25:
SP26: -
SP27:

ExUns: 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k · 12l
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for UBE2J2 Gene

GeneLoc Exon Structure for
UBE2J2
ECgene alternative splicing isoforms for
UBE2J2

Expression for UBE2J2 Gene

mRNA expression in normal human tissues for UBE2J2 Gene

Protein differential expression in normal tissues from HIPED for UBE2J2 Gene

This gene is overexpressed in Testis (30.5), Retina (21.5), and Placenta (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2J2 Gene



SOURCE GeneReport for Unigene cluster for UBE2J2 Gene Hs.191987

genes like me logo Genes that share expression patterns with UBE2J2: view

Protein tissue co-expression partners for UBE2J2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2J2 Gene

Orthologs for UBE2J2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2J2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2J2 35
  • 89.7 (n)
  • 95.37 (a)
UBE2J2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2J2 35
  • 89.58 (n)
  • 95.75 (a)
UBE2J2 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2j2 35
  • 86.87 (n)
  • 94.21 (a)
Ube2j2 16
Ube2j2 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2J2 35
  • 94.49 (n)
  • 92.91 (a)
rat
(Rattus norvegicus)
Mammalia Ube2j2 35
  • 86.49 (n)
  • 94.98 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2J2 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2J2 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2J2 35
  • 79.92 (n)
  • 91.51 (a)
UBE2J2 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2J2 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2j2 35
  • 76.45 (n)
  • 90.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5968 35
zebrafish
(Danio rerio)
Actinopterygii ube2j2 35
  • 74.77 (n)
  • 88.03 (a)
ube2j2 36
  • 88 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005954 35
  • 55.51 (n)
  • 60.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5823 35
  • 55.94 (n)
  • 57.36 (a)
CG5823 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ubc-26 35
  • 61.74 (n)
  • 60.95 (a)
ubc-15 36
  • 41 (a)
OneToMany
ubc-26 36
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR372W 35
  • 51.72 (n)
  • 45.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20395g 35
  • 55.41 (n)
  • 56.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC6 35
  • 57.59 (n)
  • 58.86 (a)
UBC6 36
  • 41 (a)
OneToMany
UBC6 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC34 35
  • 55.22 (n)
  • 53.01 (a)
rice
(Oryza sativa)
Liliopsida Os06g0193000 35
  • 52.75 (n)
  • 48.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc6 35
  • 55.41 (n)
  • 54.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToOne
Species with no ortholog for UBE2J2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2J2 Gene

ENSEMBL:
Gene Tree for UBE2J2 (if available)
TreeFam:
Gene Tree for UBE2J2 (if available)

Paralogs for UBE2J2 Gene

Paralogs for UBE2J2 Gene

genes like me logo Genes that share paralogs with UBE2J2: view

Variants for UBE2J2 Gene

Sequence variations from dbSNP and Humsavar for UBE2J2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs912852 -- 1,271,119(+) CCAGC(A/G)GGTTC intron-variant
rs1058146 -- 1,255,275(-) AACTT(G/T)TTTGT reference, missense
rs1058161 -- 1,255,143(-) ACCTC(A/G)GCAGG utr-variant-3-prime
rs3818646 -- 1,256,490(+) AAGAC(C/T)GAGAG intron-variant
rs3829743 -- 1,255,365(+) TGCCC(A/G)TTGAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UBE2J2 Gene

Variant ID Type Subtype PubMed ID
nsv10161 CNV Gain+Loss 18304495
nsv517709 CNV Gain+Loss 19592680
dgv2n67 CNV Gain 20364138
nsv871547 CNV Loss 21882294
dgv10n71 CNV Loss 21882294
dgv11n71 CNV Loss 21882294
dgv12n71 CNV Loss 21882294
nsv470680 CNV Loss 18288195
dgv17n71 CNV Loss 21882294
nsv871553 CNV Loss 21882294
dgv19n71 CNV Loss 21882294
dgv20n71 CNV Loss 21882294
nsv870527 CNV Gain 21882294
nsv469848 CNV Gain 16826518
dgv21n71 CNV Loss 21882294
nsv871744 CNV Gain 21882294
nsv482937 CNV Loss 15286789
dgv22n71 CNV Loss 21882294
nsv871107 CNV Loss 21882294
dgv23n71 CNV Loss 21882294
nsv871329 CNV Gain 21882294
dgv25n71 CNV Loss 21882294
dgv26n71 CNV Loss 21882294
nsv455661 CNV Loss 19166990
nsv871327 CNV Loss 21882294
nsv870639 CNV Loss 21882294
nsv871666 CNV Gain+Loss 21882294
nsv871965 CNV Loss 21882294
nsv817616 CNV Loss 17921354
dgv28n71 CNV Gain 21882294
dgv8e1 CNV Complex 17122850
dgv29n71 CNV Loss 21882294
esv2745807 CNV Deletion 23290073
nsv870963 CNV Loss 21882294

Variation tolerance for UBE2J2 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2J2 Gene

HapMap Linkage Disequilibrium report
UBE2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2J2 Gene

Disorders for UBE2J2 Gene

Relevant External Links for UBE2J2

Genetic Association Database (GAD)
UBE2J2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2J2

No disorders were found for UBE2J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2J2 Gene

Publications for UBE2J2 Gene

  1. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). (PMID: 11278356) Tiwari S. … Weissman A.M. (J. Biol. Chem. 2001) 2 3 4 67
  2. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. (PMID: 24807418) van de Weijer M.L. … Lebbink R.J. (Nat. Commun. 2014) 3
  3. The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation. (PMID: 25083800) Lam S.Y. … Fleming J.V. (Biochem. Biophys. Res. Commun. 2014) 3
  4. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). (PMID: 24019521) El Khouri E. … Delaunay-Moisan A. (J. Biol. Chem. 2013) 3
  5. High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy. (PMID: 24270810) Hasson S.A. … Youle R.J. (Nature 2013) 3

Products for UBE2J2 Gene

Sources for UBE2J2 Gene

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