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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBE2J2 Gene

protein-coding GIFtS: 59
GCID: GC01M001182

ubiquitin-conjugating enzyme E2, J2

(Previous names: ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)...)

Explore 1 disease affiliated with
UBE2J2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2, J2¹ ²		Ubc6p¹
NCUBE2¹ ² ³		PRO2121²
Ubiquitin-Conjugating Enzyme E2, J2 (UBC6 Homolog, Yeast)¹ ²		Ubiquitin Conjugating Enzyme 6²
Non-Canonical Ubiquitin-Conjugating Enzyme 2² ³		Ubiquitin Conjugating Enzyme E2, J2²
NCUBE-2² ³		Ubiquitin-Conjugating Enzyme E2 J2²
EC 6.3.2.19³ ⁸		Yeast UBC6 Homolog²

External Ids:	HGNC: 19268¹	Entrez Gene: 118424²	Ensembl: ENSG00000160087⁷	UniProtKB: Q8N2K1³

Export aliases for UBE2J2 gene to outside databases

Previous GC identifers: GC01M000941 GC01M001066 GC01M001095 GC01M001229 GC01M000461

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2J2:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived

proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or

E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the

E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple

alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants

has not been defined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective

degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004350.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBE2J2 gene promoter:
AhR NF-1 LCR-F1 Tal-1beta Roaz N-Myc CP2 ITF-2 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBE2J2 promoter sequence

Search SABiosciences Chromatin IP Primers for UBE2J2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2J2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.33 Ensembl cytogenetic band: 1p36.33 HGNC cytogenetic band: 1p36.33

UBE2J2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2J2 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M001182: view genomic region (about GC identifiers)

Start:	1,189,289 bp from pter	End:	1,209,265 bp from pter
Size:	19,977 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 J2

Size: 259 amino acids; 28898 Da

Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein (By similarity)

Sequence caution: Sequence=BM544827; Type=Frameshift; Positions=Several; Sequence=BM544827; Type=Miscellaneous

discrepancy;

1 PDB 3D structure from and Proteopedia for UBE2J2:

2F4W (3D)

Secondary accessions: A8MYC7 Q504T9 Q96N26 Q96T84

Alternative splicing: 3 isoforms: Q8N2K1-1 Q8N2K1-2 Q8N2K1-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2J2: NX_Q8N2K1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N2K1

4 DME Specific Peptides for UBE2J2 (Q8N2K1)

NTRLCLS

HPDTWNP

WNPAWSV

NILEWHYV

UBE2J2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_477515.2 NP_919296.1 NP_919439.1 NP_919440.1

ENSEMBL proteins:

ENSP00000407565 ENSP00000305826 ENSP00000383718 ENSP00000423880 ENSP00000353653

ENSP00000383719 ENSP00000427024 ENSP00000393301 ENSP00000425419 ENSP00000422103

ENSP00000425543 ENSP00000423480 ENSP00000401898 ENSP00000424342 ENSP00000427244

ENSP00000340197 ENSP00000344857 ENSP00000342541

Reactome Protein details: Q8N2K1
Human Recombinant Protein Products:

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	ProSpec Recombinant Protein for UBE2J2
	Uscn Proteins for UBE2J2

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	--	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

UBE2J2 for ontologies About GeneDecksing

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	Uscn Antibodies for UBE2J2
	Search ThermoFisher Antibodies for UBE2J2

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	Uscn ELISAs and CLIAs for UBE2J2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBE2J2 for domains About GeneDecksing

2 InterPro domains/families:

IPR016135 UBQ-conjugating_enzyme/RWD

IPR000608 UBQ-conjugat_E2

Graphical View of Domain Structure for InterPro Entry Q8N2K1

ProtoNet protein and cluster: Q8N2K1

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective

degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity)

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19¹ ²

miRNA Products:		OriGene 3'-UTR Clone (see all 4): UBE2J2 Browse MicroRNA Expression Plasmids
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		GenScript: all cDNA clones in your preferred vector (see all 4): UBE2J2 (NM_058167)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J2

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016881	acid-amino acid ligase activity	--	--

UBE2J2 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for UBE2J2:

Cell cycle / mitosis defect

Increased cell death in HCT116

Animal Models:
1 MGI phenotypic allele

for Ube2j2 (no phenotypes)

UBE2J2 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Antigen processing: Ubiquitination & Proteasome degradation

	Antigen processing: Ubiquitination & Proteasome degradation	1.00			Polyubiquitination of substrate	0.75
	Class I MHC mediated antigen processing & presentation	0.83			Ubiquitin mediated proteolysis	0.36

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

	Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway	1.00			Parkin-Ubiquitin Proteasomal System pathway	0.93
	Proteolysis_Role of Parkin in the Ubiquitin-Proteasomal Pathway	0.93

Immune System

Immune System

1.00

Adaptive Immune System

0.59

Parkinsons Disease Pathway

Parkinsons Disease Pathway

1.00

Ubiquitin-Proteasome Dependent Proteolysis

Ubiquitin-Proteasome Dependent Proteolysis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for UBE2J2

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2J2

	Ubiquitin-Proteasome Dependent Proteolysis
	Remodeling of Adherens Junctions

1 GeneGo (Thomson Reuters) Pathway for UBE2J2

Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

2 BioSystems Pathways for UBE2J2

	Parkinsons Disease Pathway
	Parkin-Ubiquitin Proteasomal System pathway

5 Reactome Pathways for UBE2J2

	Antigen processing: Ubiquitination & Proteasome degradation
	Polyubiquitination of substrate
	Adaptive Immune System
	Class I MHC mediated antigen processing & presentation
	Immune System

3 Kegg Pathways (Kegg details for UBE2J2):

	Ubiquitin mediated proteolysis
	Protein processing in endoplasmic reticulum
	Parkinson's disease

UniProtKB/Swiss-Prot: UB2J2_HUMAN, Q8N2K1

Pathway: Protein modification; protein ubiquitination

UBE2J2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for UBE2J2

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/36 Interacting proteins for UBE2J2 (Q8N2K1³ ENSP00000383719⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 36)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBE2G2	P60604³, ENSP00000338348⁴	I2D: score=2 STRING: ENSP00000338348
ICMT	O60725³, ENSP00000343552⁴	I2D: score=1 STRING: ENSP00000343552
MGRN1	O60291³, ENSP00000262370⁴	I2D: score=1 STRING: ENSP00000262370
PDE4DIP	Q5VU43³, ENSP00000358360⁴	I2D: score=1 STRING: ENSP00000358360
TRIM25	Q14258³, ENSP00000323889⁴	I2D: score=1 STRING: ENSP00000323889

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006986	response to unfolded protein	IEA	--

UBE2J2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UBE2J2

4 HMDB Compounds for UBE2J2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

Search CenterWatch for drugs/clinical trials and news about UBE2J2 / UB2J2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UBE2J2 gene (5 alternative transcripts):

NM_058167.2 NM_194315.1 NM_194457.1 NM_194458.1 NM_194316.1

Unigene Cluster for UBE2J2:

Ubiquitin-conjugating enzyme E2, J2

Hs.191987 [show with all ESTs]

Unigene Representative Sequence: NM_194458

18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):

ENST00000450390(uc001adm.3 uc001ado.3 uc001adp.3 uc001adr.3)

ENST00000349431 ENST00000400929 ENST00000464036 ENST00000360466 ENST00000400930

ENST00000467339 ENST00000473215 ENST00000435198 ENST00000509720 ENST00000491779

ENST00000466752 ENST00000503294 ENST00000477894 ENST00000471154 ENST00000422076

ENST00000502382 ENST00000461142

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		hsa-miR-3163 hsa-miR-299-5p hsa-miR-659 hsa-miR-3662
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Additional cDNA sequence:

AF296658.1 AK056065.1 AK075017.1 AK098803.1 AK291935.1 BC027728.2 BC052579.1 BC094777.1

BC104890.1 BC113430.1 BC143657.1

19 DOTS entries:

DT.100881363 DT.40283075 DT.100042059 DT.100881365 DT.425940 DT.419470 DT.95076950 DT.95193420

DT.121442457 DT.95076949 DT.97836722 DT.121442506 DT.100809540 DT.100881349 DT.121442490 DT.91915343

DT.95076884 DT.100881357 DT.95279782

24/358 AceView cDNA sequences (see all 358):

BM794599 BM931427 BM765800 BE775090 NM_194457 CR610022 BG106735 BM765311

BG112933 BC027728 AA353405 AI440313 AI346527 CD672671 CK431124 BM772182

BE775069 BM765278 BF476166 AI250944 BU737307 BF037192 AK125883 BM766232

GeneLoc Exon Structure

5/27 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J2 (see all 27) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·
SP1:					-		-		-		-		-						-		-		-		-				-		-		-		-								-		-
SP2:					-		-		-		-		-						-		-		-						-		-		-		-								-		-
SP3:											-		-						-		-		-		-				-		-		-		-								-		-
SP4:																			-		-		-						-		-		-		-								-		-
SP5:																			-		-		-		-				-				-		-								-		-

ExUns:	12c	·	12d	·	12e	·	12f	·	12g	·	12h	·	12i	·	12j	·	12k	·	12l
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for UBE2J2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBE2J2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCCGGGGGC

About this image
See UBE2J2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2J2

SOURCE GeneReport for Unigene cluster: Hs.191987

SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2J2:

Ubiquitination (Ubiquitylation) Pathway in human mouse rat

Unfolded Protein Response in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2J2 gene from 9/34 species (see all 34) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	UBE2J2¹	ubiquitin-conjugating enzyme E2, J2	79.92(n) 91.51(a)		419421 XM_001233676.1 XP_001233677.1
lizard (Anolis carolinensis)	Reptilia	UBE2J2⁶	--	90(a)	1 ↔ 1	GL344341.1(27277-33511)
African clawed frog (Xenopus laevis)	Amphibia	Xl.5968²	Xenopus laevis transcribed sequence with moderate similarity more	79.49(n)		BX848004.1
zebrafish (Danio rerio)	Actinopterygii	ube2j2¹	ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, more	74.77(n) 88.03(a)		100037384 NM_001089535.1 NP_001083004.1
fruit fly (Drosophila melanogaster)	Insecta	CG5823¹	CG5823	55.43(n) 56.98(a)		42105 NM_142374.2 NP_650631.1
worm (Caenorhabditis elegans)	Secernentea	ubc-26¹	Protein UBC-26	61.74(n) 60.95(a)		259424 NM_182122.2 NP_871922.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	UBC6(YER100W)⁴ UBC6¹	Ubiquitin-conjugating enzyme involved in ER-associated more⁴ Ubc6p¹	57.59(n)¹ 58.86(a)¹		5(359562-360314)⁴ 856837^{1, 4} NP_011026.3¹ NP_011026.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	UBC34¹	ubiquitin-conjugating enzyme E2 34	55.22(n) 53.01(a)		838300 NM_001084085.1 NP_001077554.1
rice (Oryza sativa)	Liliopsida	Os06g0193000¹	hypothetical protein	55.3(n) 52.27(a)		4340379 NM_001063575.1 NP_001057040.1

ENSEMBL Gene Tree for UBE2J2 (if available)
TreeFam Gene Tree for UBE2J2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for UBE2J2 gene

UBE2J1²

10 SIMAP similar genes for UBE2J2 using alignment to 10 protein entries: UB2J2_HUMAN (see all proteins):

UBE2J1 UBE2DNL UBE2A UBE2D3 UBE2D2 UBE2D1

UBE2N UBE2D4 UBE2B UBE2E1

UBE2J2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs112743287^1,2		--	1188944(+)	`GATTAT/GAGGCG`	4	--	ds500¹		2		CSA WA	120
rs150707858^1,2		--	1188949(+)	`TAGGCA/GGCAGC`	4	--	ds500¹		0	--	--	--	--
rs137910284^1,2		--	1188965(+)	`CACCCA/GGCAGT`	4	--	ds500¹		0	--	--	--	--
rs12120541^1,2	C,H	--	1188995(+)	`CTATTC/AGTTAG`	4	--	ds500¹		6		NS EA NA	424
rs149470332^1,2		--	1189022(+)	`AGCCTC/GGGGAG`	4	--	ds500¹		0	--	--	--	--
rs115896710^1,2	F,	--	1189054(+)	`GCTGGC/TGGTCA`	4	--	ds500¹		1		WA	118
rs115328820^1,2		--	1189199(+)	`CAGGCC/TAGCAG`	4	--	ds500¹		1		NA	120
rs201778928^1,2		--	1189319(+)	`AGACC-/TTTTTT`	4	--	ut3¹		0	--	--	--	--
rs186580484^1,2		--	1189327(+)	`TTTTTC/TCCACA`	4	--	ut3¹		0	--	--	--	--
rs147323508^1,2		--	1189359(+)	`ATTGGC/TAAATT`	4	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for UBE2J2 (1189289 - 1209265 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for UBE2J2
4 CNVs: 0001 3275 30362 9864

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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UBE2J2 for disorders About GeneDecksing

1 disease for UBE2J2: About MalaCards

parkinson's disease

Export disorders for UBE2J2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for UBE2J2 gene, integrated from 9 sources (see all 17):
(articles sorted by number of sources associating them with UBE2J2)

Utopia: connect your pdf to the dynamic
world of online information

Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). (PubMed id 11278356)^{1, 2, 3} Tiwari S. and Weissman A.M. (2001)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)¹ Usenovic M....Krainc D. (2012)
A human ubiquitin conjugating enzyme (E2)-HECT E3 liga se structure-function screen. (PubMed id 22496338)¹ Sheng Y....Dhe-Paganon S. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
The E2 ubiquitin-conjugating enzymes direct polyubiqu itination to preferred lysines. (PubMed id 20061386)¹ David Y....Navon A. (2010)
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)¹ Markson G....Sanderson C.M. (2009)
Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress. (PubMed id 16720581)¹ Oh R.S....Rommens J.M. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 118424	HGNC: 19268	AceView: UBE2J2	Ensembl:ENSG00000160087	euGenes: HUgn118424
ECgene: UBE2J2	Kegg: 118424	H-InvDB: UBE2J2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for UBE2J2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UBE2J2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for UBE2J2 gene:
Search GeneIP for patents involving UBE2J2

GeneCards and IP:
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ubiquitin-conjugating enzyme E2, J2

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UBE2J2 Gene

ubiquitin-conjugating enzyme E2, J2

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