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Aliases for UBE2J2 Gene

Aliases for UBE2J2 Gene

  • Ubiquitin Conjugating Enzyme E2 J2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2, J2 (UBC6 Homolog, Yeast) 2 3
  • Non-Canonical Ubiquitin-Conjugating Enzyme 2 3 4
  • E2 Ubiquitin-Conjugating Enzyme J2 3 4
  • NCUBE-2 3 4
  • NCUBE2 3 4
  • Ubiquitin-Conjugating Enzyme E2, J2 2
  • Ubiquitin-Conjugating Enzyme E2 J2 3
  • Ubiquitin Conjugating Enzyme 6 3
  • Yeast UBC6 Homolog 3
  • EC 6.3.2.19 61
  • EC 2.3.2.23 4
  • PRO2121 3

External Ids for UBE2J2 Gene

Previous GeneCards Identifiers for UBE2J2 Gene

  • GC01M000941
  • GC01M001066
  • GC01M001095
  • GC01M001229
  • GC01M001182
  • GC01M000461
  • GC01M001189

Summaries for UBE2J2 Gene

Entrez Gene Summary for UBE2J2 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2J2 Gene

UBE2J2 (Ubiquitin Conjugating Enzyme E2 J2) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2J1.

UniProtKB/Swiss-Prot for UBE2J2 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2J2 Gene

Genomics for UBE2J2 Gene

Regulatory Elements for UBE2J2 Gene

Enhancers for UBE2J2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F001127 1.7 FANTOM5 Ensembl ENCODE 11.9 +144.6 144644 4.0 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 TTLL10 TTLL10-AS1 B3GALT6 SDF4 FAM132A UBE2J2 C1orf159 AGRN VWA1 GC01M001125
GH01F001156 1.5 FANTOM5 Ensembl ENCODE 11.8 +115.5 115451 4.4 HDGF ATF1 CREB3L1 ARID4B ZNF48 KDM4B SP5 MBD2 MEF2D SMARCA4 LINC01786 TTLL10 LOC100287934 TTLL10-AS1 MIR6727 CICP3 UBE2J2 LINC00115 ENSG00000240731 ENSG00000272455
GH01F001370 1.4 Ensembl ENCODE 11.5 -97.9 -97850 2.3 HDGF PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 ENSG00000229905 ENSG00000235146 WBP1LP6 LINC01786 UBE2J2 PUSL1 AURKAIP1 TAS1R3 MRPL20 GC01M001374
GH01F001131 1.3 Ensembl ENCODE 11.9 +138.8 138805 6.5 HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ZNF207 TTLL10 TTLL10-AS1 SDF4 B3GALT6 FAM132A UBE2J2 C1orf159 LINC01342 GC01M001125
GH01F001343 1.1 ENCODE 11.3 -73.1 -73054 7.1 HDGF MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 FOS ZNF263 ANKRD65 ATAD3B UBE2J2 LINC01786 MRPL20 TAS1R3 LINC01128 MIR6808 DVL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2J2 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2J2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000528952 185 1801 PKNOX1 CREB3L1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207 FOS

Genomic Location for UBE2J2 Gene

Chromosome:
1
Start:
1,253,909 bp from pter
End:
1,273,885 bp from pter
Size:
19,977 bases
Orientation:
Minus strand

Genomic View for UBE2J2 Gene

Genes around UBE2J2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2J2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2J2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2J2 Gene

Proteins for UBE2J2 Gene

  • Protein details for UBE2J2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N2K1-UB2J2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 J2
    Protein Accession:
    Q8N2K1
    Secondary Accessions:
    • A8MYC7
    • Q504T9
    • Q96N26
    • Q96T84

    Protein attributes for UBE2J2 Gene

    Size:
    259 amino acids
    Molecular mass:
    28898 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BM544827; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BM544827; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2J2 Gene

    Alternative splice isoforms for UBE2J2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2J2 Gene

Selected DME Specific Peptides for UBE2J2 Gene

Q8N2K1:
  • WNPAWSV
  • NTRLCLS
  • NILEWHYV
  • HPDTWNP

Post-translational modifications for UBE2J2 Gene

  • Ubiquitination at Lys 64
  • Modification sites at PhosphoSitePlus

Domains & Families for UBE2J2 Gene

Gene Families for UBE2J2 Gene

Protein Domains for UBE2J2 Gene

Suggested Antigen Peptide Sequences for UBE2J2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N2K1

UniProtKB/Swiss-Prot:

UB2J2_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2J2: view

Function for UBE2J2 Gene

Molecular function for UBE2J2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Enzyme Numbers (IUBMB) for UBE2J2 Gene

Gene Ontology (GO) - Molecular Function for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 24019521
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2J2: view
genes like me logo Genes that share phenotypes with UBE2J2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2J2

miRNA for UBE2J2 Gene

miRTarBase miRNAs that target UBE2J2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2J2 Gene

Localization for UBE2J2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2J2 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2J2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 1
mitochondrion 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IPI 24807418
GO:0005783 endoplasmic reticulum IEA,IBA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UBE2J2: view

Pathways & Interactions for UBE2J2 Gene

genes like me logo Genes that share pathways with UBE2J2: view

UniProtKB/Swiss-Prot Q8N2K1-UB2J2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2J2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IBA --
GO:0006986 response to unfolded protein IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 24807418
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with UBE2J2: view

No data available for SIGNOR curated interactions for UBE2J2 Gene

Drugs & Compounds for UBE2J2 Gene

(3) Drugs for UBE2J2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2J2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2J2: view

Transcripts for UBE2J2 Gene

Unigene Clusters for UBE2J2 Gene

Ubiquitin-conjugating enzyme E2, J2:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ·
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - - - - - -
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: - - - - - - - - - - -
SP16: - - - - - - - - - - - -
SP17: - - - - - - - - - - -
SP18: - - - - - -
SP19: - - - - - - - - -
SP20: - -
SP21: - - - - - - - - - -
SP22: - - - - - - - - - - - - - - - - -
SP23: - -
SP24: - - - - - - - - -
SP25:
SP26: -
SP27:

ExUns: 12c · 12d · 12e · 12f · 12g · 12h · 12i · 12j · 12k · 12l
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:
SP26:
SP27:

Relevant External Links for UBE2J2 Gene

GeneLoc Exon Structure for
UBE2J2
ECgene alternative splicing isoforms for
UBE2J2

Expression for UBE2J2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2J2 Gene

Protein differential expression in normal tissues from HIPED for UBE2J2 Gene

This gene is overexpressed in Testis (30.5), Retina (21.5), and Placenta (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2J2 Gene



Protein tissue co-expression partners for UBE2J2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2J2 Gene:

UBE2J2

SOURCE GeneReport for Unigene cluster for UBE2J2 Gene:

Hs.191987
genes like me logo Genes that share expression patterns with UBE2J2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2J2 Gene

Orthologs for UBE2J2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2J2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2J2 34
  • 94.49 (n)
oppossum
(Monodelphis domestica)
Mammalia UBE2J2 35
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2J2 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2J2 34 35
  • 89.7 (n)
dog
(Canis familiaris)
Mammalia UBE2J2 34 35
  • 89.58 (n)
mouse
(Mus musculus)
Mammalia Ube2j2 34 16 35
  • 86.87 (n)
rat
(Rattus norvegicus)
Mammalia Ube2j2 34
  • 86.49 (n)
chicken
(Gallus gallus)
Aves UBE2J2 34 35
  • 79.92 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2J2 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2j2 34
  • 76.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5968 34
zebrafish
(Danio rerio)
Actinopterygii ube2j2 34 35
  • 74.77 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5823 34 35
  • 55.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005954 34
  • 55.51 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-26 34 35
  • 61.74 (n)
ubc-15 35
  • 41 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC6 34 35 37
  • 57.59 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20395g 34
  • 55.41 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR372W 34
  • 51.72 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC34 34
  • 55.22 (n)
rice
(Oryza sativa)
Liliopsida Os06g0193000 34
  • 52.75 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 63 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc6 34
  • 55.41 (n)
Species where no ortholog for UBE2J2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2J2 Gene

ENSEMBL:
Gene Tree for UBE2J2 (if available)
TreeFam:
Gene Tree for UBE2J2 (if available)

Paralogs for UBE2J2 Gene

Paralogs for UBE2J2 Gene

genes like me logo Genes that share paralogs with UBE2J2: view

Variants for UBE2J2 Gene

Sequence variations from dbSNP and Humsavar for UBE2J2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1058146 -- 1,255,275(-) AACTT(G/T)TTTGT reference, missense
rs1058161 -- 1,255,143(-) ACCTC(A/G)GCAGG utr-variant-3-prime
rs111357358 -- 1,274,102(+) AGGGC(A/G)GCAGG nc-transcript-variant, upstream-variant-2KB
rs111483377 -- 1,257,416(+) AGCTC(A/G)GCTCC intron-variant
rs111487085 -- 1,265,111(+) AGAAA(C/T)GAAGA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2J2 Gene

Variant ID Type Subtype PubMed ID
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544964 CNV loss 21841781
nsv544965 CNV loss 21841781
nsv817616 CNV loss 17921354
nsv950452 CNV deletion 24416366
nsv469848 CNV gain 16826518
nsv455661 CNV loss 19166990
nsv1160772 CNV duplication 26073780
nsv1118089 CNV deletion 24896259
nsv1074020 CNV deletion 25765185
nsv10161 CNV gain+loss 18304495
nsv1003578 CNV gain 25217958
esv2758912 CNV loss 17122850
dgv2n67 CNV gain 20364138

Variation tolerance for UBE2J2 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.20; 39.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2J2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2J2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2J2 Gene

Disorders for UBE2J2 Gene

Relevant External Links for UBE2J2

Genetic Association Database (GAD)
UBE2J2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2J2

No disorders were found for UBE2J2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2J2 Gene

Publications for UBE2J2 Gene

  1. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). (PMID: 11278356) Tiwari S. … Weissman A.M. (J. Biol. Chem. 2001) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. (PMID: 26949039) Zhang W. … Sidhu S.S. (Mol. Cell 2016) 3 64
  4. The human ubiquitin conjugating enzyme UBE2J2 (Ubc6) is a substrate for proteasomal degradation. (PMID: 25083800) Lam S.Y. … Fleming J.V. (Biochem. Biophys. Res. Commun. 2014) 3 64
  5. A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. (PMID: 24807418) van de Weijer M.L. … Lebbink R.J. (Nat. Commun. 2014) 3 64

Products for UBE2J2 Gene

Sources for UBE2J2 Gene

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