Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2J1 Gene

protein-coding   GIFtS: 60
GCID: GC06M090093

Ubiquitin-Conjugating Enzyme E2, J1

(Previous names: ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast))
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2, J11 2     HSU932432
Ubiquitin-Conjugating Enzyme E2, J1 (UBC6 Homolog, Yeast)1 2     HSUBC6e2
Non-Canonical Ubiquitin-Conjugating Enzyme 12 3     UBC62
Yeast Ubiquitin-Conjugating Enzyme UBC6 Homolog E2 3     Ubc6p2
NCUBE-12 3     Ubiquitin-Conjugating Enzyme E2 J12
NCUBE12 3     Ubiquitin-Conjugating Enzyme E2, J1, U2
HSPC1532     EC 6.3.2.193
HSPC2052     HsUBC6e3

External Ids:    HGNC: 175981   Entrez Gene: 514652   Ensembl: ENSG000001988337   UniProtKB: Q9Y3853   

Export aliases for UBE2J1 gene to outside databases

Previous GC identifers: GC06M090003 GC06M090032 GC06M090031 GC06M087253


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2J1 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the
membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the
ubiquitin-proteasome system. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2J1 Gene: 
UBE2J1 (ubiquitin-conjugating enzyme E2, J1) is a protein-coding gene. Diseases associated with UBE2J1 include hemochromatosis, and parkinson's disease, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is UBE2J2.

UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation
of misfolded membrane proteins from the endoplasmic reticulum (ERAD)

Gene Wiki entry for UBE2J1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007299.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2J1 gene promoter:
         Elk-1   Pax-6   Nkx2-5   HNF-4alpha2   HNF-4alpha1   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2J1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2J1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2J1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

UBE2J1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2J1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M090093:  view genomic region     (about GC identifiers)

Start:
90,036,344 bp from pter      End:
90,062,619 bp from pter
Size:
26,276 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 J1  
Size: 318 amino acids; 35199 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass type IV membrane protein
Sequence caution: Sequence=AAD34071.1; Type=Erroneous initiation; Sequence=AAF36125.1; Type=Frameshift;
Positions=119;
Secondary accessions: A8K3F9 Q53F25 Q5W0N4 Q9BZ32 Q9NQL3 Q9NY66 Q9P011 Q9P0S0 Q9UF10

Explore the universe of human proteins at neXtProt for UBE2J1: NX_Q9Y385

Explore proteomics data for UBE2J1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y385

  • UBE2J1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2J1 Protein Expression
    REFSEQ proteins: NP_057105.2  
    ENSEMBL proteins: 
     ENSP00000451261  
    Reactome Protein details: Q9Y385
    Human Recombinant Protein Products for UBE2J1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UBE2J1
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for UBE2J1
    OriGene Protein Over-expression Lysate for UBE2J1
    OriGene MassSpec for UBE2J1 
    OriGene Custom Protein Services for UBE2J1
    GenScript Custom Purified and Recombinant Proteins Services for UBE2J1
    Novus Biologicals UBE2J1 Protein
    Novus Biologicals UBE2J1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBE2J1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    UBE2J1 for ontologies           About GeneDecksing



    UBE2J1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UBE2J1
    OriGene Custom Antibody Services for UBE2J1
    GenScript Custom Superior Antibodies Services for UBE2J1
    Novus Biologicals UBE2J1 Antibodies
    Abcam antibodies for UBE2J1
    Cloud-Clone Corp. Antibodies for UBE2J1 
    ThermoFisher Antibodies for UBE2J1
    LSBio Antibodies in human, mouse, rat for UBE2J1 

    Assay Products for UBE2J1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBE2J1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBE2J1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBE2J1 
    Cloud-Clone Corp. CLIAs for UBE2J1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q9Y385

    ProtoNet protein and cluster: Q9Y385

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2J1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2J1_HUMAN, Q9Y385
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation
    of misfolded membrane proteins from the endoplasmic reticulum (ERAD)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2J1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2J1:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2J1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2J1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2J1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2J1 

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2J1:
    hsa-mir-155 (MIRT001488)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2J1
    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2J1 (see all 93):
    hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-30d hsa-miR-371-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2J1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2J1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBE2J1
    Sirion Biotech Customized adenovirus for overexpression of UBE2J1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UBE2J1 (see all 8)
    OriGene ORF clones in mouse, rat for UBE2J1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2J1 (NM_016021)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2J1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2J1
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2J1 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2J1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBE2J1
    Search LifeMap BioReagents cell lines for UBE2J1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2J1 About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Regulation of degradation of wt-CFTR
    Regulation of degradation of wt-CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59
    4Immune System
    Immune System0.56
    Adaptive Immune System0.56
    5Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UBE2J1
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2J1
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    3 GeneGo (Thomson Reuters) Pathways for UBE2J1
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    2 BioSystems Pathways for UBE2J1
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway

    4        Reactome Pathways for UBE2J1
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    3         Kegg Pathways  (Kegg details for UBE2J1):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385
    Pathway: Protein modification; protein ubiquitination


    UBE2J1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2J1

    5/28 Interacting proteins for UBE2J1 (Q9Y3853) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183574Q999423I2D: score=2 
    ENSG00000223767Q999423I2D: score=2 
    ENSG00000225452Q999423I2D: score=2 
    ENSG00000227277Q999423I2D: score=2 
    ENSG00000228405Q999423I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018279protein N-linked glycosylation via asparagine IMP--
    GO:0030433ER-associated protein catabolic process IMP--

    UBE2J1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2J1 (UB2J1)

    4 HMDB Compounds for UBE2J1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2J1 / UB2J1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2J1 gene: 
    NM_016021.2  

    Unigene Cluster for UBE2J1:

    Ubiquitin-conjugating enzyme E2, J1
    Hs.163776  [show with all ESTs]
    Unigene Representative Sequence: NM_016021
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000435041(uc003pnc.3)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2J1
    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2J1 (see all 93):
    hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-30d hsa-miR-371-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2J1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2J1
    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2J1 (see all 8)
    OriGene ORF clones in mouse, rat for UBE2J1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2J1 (NM_016021)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2J1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2J1
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2J1 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2J1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBE2J1
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2J1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2J1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2J1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2J1

    Additional mRNA sequence: 

    AB075487.1 AF151039.1 AF151834.1 AF161502.1 AJ245898.1 AJ420479.1 AJ420522.1 AJ420578.1 
    AJ420600.1 AK223464.1 AK290574.1 AK300629.1 BC013973.1 U93243.1 

    13 DOTS entries:

    DT.452520  DT.91754919  DT.92035712  DT.91754932  DT.100726380  DT.100645848  DT.100645843  DT.91754923 
    DT.87001128  DT.95224761  DT.101976909  DT.121383951  DT.95141421 

    24/349 AceView cDNA sequences (see all 349):

    AA721265 CR618158 BM463539 CR608832 AW235268 BG566075 BQ773850 BU507628 
    NM_016021 AW516077 BQ437893 AA705068 AI708167 AA553859 AL121463 BM712541 
    BX956439 AW117721 AA236003 BX645216 AA811362 BV178035 AL533731 CA397036 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d
    SP1:                                      -                 -     -           -                     
    SP2:                                      -                                                         
    SP3:                                                                                                
    SP4:                                                        -     -                                 
    SP5:                                                                          -                     


    ECgene alternative splicing isoforms for UBE2J1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2J1 expression in normal human tissues (normalized intensities)      UBE2J1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UBE2J1 Expression
    About this image


    UBE2J1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             plasma cells   
     
     Lymph (Hematopoietic System)    fully expand to see all 2 entries
             LYMPH NODE   

    See UBE2J1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2J1

    SOURCE GeneReport for Unigene cluster: Hs.163776
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2J1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2J1
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2J1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2J1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2J1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2J1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2J1 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2j11 , 5 ubiquitin-conjugating enzyme E2, J15
    ubiquitin-conjugating enzyme E2J 11
    88.16(n)1
    92.45(a)1
      4 (14.61 cM)5
    562281  NM_019586.31  NP_062532.21 
     330314165 
    chicken
    (Gallus gallus)
    Aves UBE2J11 ubiquitin-conjugating enzyme E2, J1, U 73.8(n)
    77.74(a)
      395528  NM_204763.1  NP_990094.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2J16
    ubiquitin-conjugating enzyme E2, J1
    74(a)
    1 ↔ 1
    1(174997819-175017491)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ622214.12   -- 80.32(n)    BJ622214.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.287982 Danio rerio cDNA clone MGC63554 IMAGE3817181, complete more 75.23(n)    BC061451.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-61 Protein UBC-6 51.38(n)
    47.84(a)
      174217  NM_001047290.2  NP_001040755.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC66
    Ubiquitin-conjugating enzyme involved in ER-associ...
    24(a)
    1 → many
    V(359562-360314)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC321 ubiquitin-conjugating enzyme E2 32 62.07(n)
    60.69(a)
      820956  NM_112576.2  NP_566563.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g03080001 hypothetical protein 61.07(n)
    60.84(a)
      4332614  NM_001056436.1  NP_001049901.1 


    ENSEMBL Gene Tree for UBE2J1 (if available)
    TreeFam Gene Tree for UBE2J1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2J1 gene
    UBE2J22  
    1 SIMAP similar gene for UBE2J1 using alignment to 1 protein entry:     UB2J1_HUMAN:
    UBE2J2

    UBE2J1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/544 SNPs in UBE2J1 are shown (see all 544)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817057371,2
    --90036005(+) CCCCAA/GAGGCA 1 -- ds50010--------
    rs122003751,2
    C,H--90036019(+) GCTGAG/AGTCTG 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 412
    rs1392392681,2
    --90036118(+) AGAAGA/GGATCA 1 -- ds50010--------
    rs1867768841,2
    --90036240(+) TGCCTA/CGTTAG 1 -- ds50010--------
    rs1499914161,2
    --90036280(+) TAGGAC/GGTAGA 1 -- ds50010--------
    rs794564251,2
    C,F--90036328(+) AACCTT/CTGGTC 1 -- ds50011Minor allele frequency- C:0.23WA 118
    rs1912696231,2
    --90036485(+) ATTAGC/TCTTTG 1 -- ut310--------
    rs132154181,2
    C,F,H--90036511(+) AAATGC/TATTAA 1 -- ut31 ese330Minor allele frequency- T:0.21EA NA NS 3214
    rs1476902051,2
    --90036550(+) ACATAC/GGCTTT 1 -- ut310--------
    rs792826361,2
    C--90036631(+) TCTGAT/CCTATA 1 -- ut312Minor allele frequency- C:0.10NA 122

    HapMap Linkage Disequilibrium report for UBE2J1 (90036344 - 90062619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2J1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv27467CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing UBE2J1
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2J1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    4 diseases for UBE2J1:    About MalaCards
    hemochromatosis    parkinson's disease    cystic fibrosis    neuronitis


    UBE2J1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Human Genome Epidemiology (HuGE) Navigator: UBE2J1 (1 document)

    Export disorders for UBE2J1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2J1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with UBE2J1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of non-canonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. (PubMed id 10708578)1, 2, 3, 9 Lester D.H.... Houston B. (2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    4. A role for mammalian Ubc6 homologues in ER-associated protein degradation. (PubMed id 12082160)1, 2 Lenk U....Sommer T. (2002)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    6. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.H....Lin W. (2000)
    7. A meta-analysis of genome-wide data from five Europea n isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creat inine level. (PubMed id 20222955)1, 9 Pattaro C....Pramstaller P.P. (2010)
    8. Unassembled CD147 is an endogenous endoplasmic reticul um-associated degradation substrate. (PubMed id 23097496)1 Tyler R.E....Kopito R.R. (2012)
    9. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PubMed id 22607976)2 Sato T.... Kai H. (2012)
    10. Dual role of ancient ubiquitous protein 1 (AUP1) in l ipid droplet accumulation and endoplasmic reticulum (ER) protein quality contro l. (PubMed id 21857022)1 Klemm E.J....Ploegh H.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51465 HGNC: 17598 AceView: UBE2J1 Ensembl:ENSG00000198833 euGenes: HUgn51465
    ECgene: UBE2J1 Kegg: 51465 H-InvDB: UBE2J1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2J1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2J1 gene:
    Search GeneIP for patents involving UBE2J1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for UBE2J1 (UBE2J1)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBE2J1   OriGene RNAi products in human, mouse, rat for UBE2J1  
     OriGene qPCR primer pairs and template standards for UBE2J1   OriGene Protein Over-expression Lysate for UBE2J1  
     OriGene MassSpec something-or-other for UBE2J1   OriGene clones in human, mouse for UBE2J1  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBE2J1   OriGene Purified Protein for UBE2J1  
     OriGene ORF clones in mouse, rat for UBE2J1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBE2J1   OriGene Custom Protein Services for UBE2J1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2J1
     QIAGEN SeqTarget long-range PCR primers for resequencing UBE2J1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2J1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2J1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2J1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2J1
     GenScript Custom Purified and Recombinant Proteins Services for UBE2J1 GenScript cDNA clones with any tag delivered in your preferred vector for UBE2J1
     GenScript Custom Assay Services for UBE2J1 GenScript Custom Superior Antibodies Services for UBE2J1
     GenScript Custom overexpressing Cell Line Services for UBE2J1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UBE2J1 promoter
     Search Chromatin IP Primers for UBE2J1
     RT2 qPCR Primer Assay in human, mouse, rat UBE2J1
     Search GNC Networks for UBE2J1
     SABiosciences PCR Arrays including human, mouse, rat UBE2J1
     Search Tocris compounds for UBE2J1 (UB2J1)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UBE2J1 antibodies
     UBE2J1 proteins
     UBE2J1 lysates
     Antibodies for UBE2J1
     See all of Abcam's Antibodies, Kits and Proteins for UBE2J1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UBE2J1
     Antibodies for UBE2J1
     ELISAs for UBE2J1
     CLIAs for UBE2J1
     Search LifeMap BioReagents cell lines for UBE2J1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for UBE2J1
     SwitchGear Promoter luciferase reporter plasmids for UBE2J1
     ThermoFisher Antibodies for UBE2J1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2J1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2J1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2J1
    Customized:
     lentivirus for stable overexpression of UBE2J1
     lentivirus expression plasmids for stable overexpression of UBE2J1
     adenovirus for overexpression of UBE2J1
     LSBio Antibodies in human, mouse, rat for UBE2J1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBE2J1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4