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UBE2J1 Gene

protein-coding   GIFtS: 61
GCID: GC06M090037

Ubiquitin-Conjugating Enzyme E2, J1

(Previous names: ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast))
  Search for UBE2J1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2, J11 2     HSU932432
Ubiquitin-Conjugating Enzyme E2, J1 (UBC6 Homolog, Yeast)1 2     HSUBC6e2
Non-Canonical Ubiquitin-Conjugating Enzyme 12 3     UBC62
Yeast Ubiquitin-Conjugating Enzyme UBC6 Homolog E2 3     Ubc6p2
NCUBE-12 3     Ubiquitin-Conjugating Enzyme E2 J12
NCUBE12 3     Ubiquitin-Conjugating Enzyme E2, J1, U2
HSPC1532     EC 6.3.2.193
HSPC2052     HsUBC6e3

External Ids:    HGNC: 175981   Entrez Gene: 514652   Ensembl: ENSG000001988337   UniProtKB: Q9Y3853   

Export aliases for UBE2J1 gene to outside databases

Previous GC identifers: GC06M090003 GC06M090032 GC06M090031 GC06M090093 GC06M087253


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2J1 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the
membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the
ubiquitin-proteasome system. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2J1 Gene:
UBE2J1 (ubiquitin-conjugating enzyme E2, J1) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2J2.

UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385
Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation
of misfolded membrane proteins from the endoplasmic reticulum (ERAD)

Gene Wiki entry for UBE2J1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2J1 gene promoter:
         Elk-1   Pax-6   Nkx2-5   HNF-4alpha2   HNF-4alpha1   POU2F1   POU2F1b   POU2F1a   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2J1 promoter sequence
   Search Chromatin IP Primers for UBE2J1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2J1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q15   Ensembl cytogenetic band:  6q15   HGNC cytogenetic band: 6q15

UBE2J1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2J1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M090037:  view genomic region     (about GC identifiers)

Start:
90,036,344 bp from pter      End:
90,062,619 bp from pter
Size:
26,276 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 J1  
Size: 318 amino acids; 35199 Da
Sequence caution: Sequence=AAD34071.1; Type=Erroneous initiation; Sequence=AAF36125.1; Type=Frameshift;
Positions=119;
Secondary accessions: A8K3F9 Q53F25 Q5W0N4 Q9BZ32 Q9NQL3 Q9NY66 Q9P011 Q9P0S0 Q9UF10

Explore the universe of human proteins at neXtProt for UBE2J1: NX_Q9Y385

Explore proteomics data for UBE2J1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys186
  • Modification sites at PhosphoSitePlus

  • See UBE2J1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057105.2  
    ENSEMBL proteins: 
     ENSP00000451261  
    Reactome Protein details: Q9Y385

    UBE2J1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    2 InterPro protein domains:
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q9Y385

    ProtoNet protein and cluster: Q9Y385

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2J1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2J1_HUMAN, Q9Y385
    Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation
    of misfolded membrane proteins from the endoplasmic reticulum (ERAD)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with UBE2J1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2J1:
     Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2J1
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UBE2J1 (see all 93):
    hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-30d hsa-miR-371-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UB2J1_HUMAN, Q9Y385: Endoplasmic reticulum membrane; Single-pass type IV membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol3
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with UBE2J1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2J1 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt CFTR0.59
    Regulation of degradation of deltaF508 CFTR in CF0.59
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    5Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis


    Find genes that share SuperPaths with UBE2J1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2J1
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    3 GeneGo (Thomson Reuters) Pathways for UBE2J1
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Regulation of degradation of deltaF508 CFTR in CF
    Regulation of degradation of wt-CFTR

    2 BioSystems Pathways for UBE2J1
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway

    1 Reactome Pathway for UBE2J1
        Antigen processing: Ubiquitination & Proteasome degradation


    3 Kegg Pathways  (Kegg details for UBE2J1):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2J1_HUMAN, Q9Y385
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2J1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBE2J1

    Selected Interacting proteins for UBE2J1 (Q9Y3853) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183574Q999423I2D: score=2 
    ENSG00000223767Q999423I2D: score=2 
    ENSG00000225452Q999423I2D: score=2 
    ENSG00000227277Q999423I2D: score=2 
    ENSG00000228405Q999423I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0018279protein N-linked glycosylation via asparagine IMP--
    GO:0030433ER-associated ubiquitin-dependent protein catabolic process IMP--

    Find genes that share ontologies with UBE2J1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2J1 (UB2J1)

    4 HMDB Compounds for UBE2J1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2J1 gene: 
    NM_016021.2  

    Unigene Cluster for UBE2J1:

    Ubiquitin-conjugating enzyme E2, J1
    Hs.163776  [show with all ESTs]
    Unigene Representative Sequence: NM_016021
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000435041(uc003pnc.3)
    miRNA
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    hsa-miR-520e hsa-miR-3607-3p hsa-miR-607 hsa-miR-15a hsa-miR-106a hsa-miR-374a hsa-miR-30d hsa-miR-371-5p
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    Additional mRNA sequence: 

    AB075487.1 AF151039.1 AF151834.1 AF161502.1 AJ245898.1 AJ420479.1 AJ420522.1 AJ420578.1 
    AJ420600.1 AK223464.1 AK290574.1 AK300629.1 BC013973.1 U93243.1 

    13 DOTS entries:

    DT.452520  DT.91754919  DT.92035712  DT.91754932  DT.100726380  DT.100645848  DT.100645843  DT.91754923 
    DT.87001128  DT.95224761  DT.101976909  DT.121383951  DT.95141421 

    Selected AceView cDNA sequences (see all 349):

    AA721265 BQ009872 BX482869 BQ774386 CB129430 BQ773850 BM463539 BU154273 
    BM686728 BM453083 CR618158 CR608832 AW118565 BU686571 AL538922 BM984150 
    AA975459 BU688929 AW296841 AI224063 AA832284 AI222553 CB117915 AA705068 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d
    SP1:                                      -                 -     -           -                     
    SP2:                                      -                                                         
    SP3:                                                                                                
    SP4:                                                        -     -                                 
    SP5:                                                                          -                     


    ECgene alternative splicing isoforms for UBE2J1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2J1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UBE2J1 Expression
    About this image


    UBE2J1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Mature B-Cells Peripheral Blood
    UBE2J1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2J1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.163776
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2J1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2J1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2J1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2j11 , 5 ubiquitin-conjugating enzyme E2, J15
    ubiquitin-conjugating enzyme E2J 11
    88.16(n)1
    92.45(a)1
      4 (14.61 cM)5
    562281  NM_019586.31  NP_062532.21 
     330314165 
    chicken
    (Gallus gallus)
    Aves UBE2J11 ubiquitin-conjugating enzyme E2, J1 73.8(n)
    77.74(a)
      395528  NM_204763.1  NP_990094.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2J16
    ubiquitin-conjugating enzyme E2, J1
    74(a)
    1 ↔ 1
    1(174997819-175017491)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ622214.12   -- 80.32(n)    BJ622214.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.287982 Danio rerio cDNA clone MGC63554 IMAGE3817181, complete more 75.23(n)    BC061451.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-61 ubc-6 60.43(n)
    62.03(a)
      174217  NM_001047290.3  NP_001040755.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC66
    Ubiquitin-conjugating enzyme involved in ER-associ...
    28(a)
    1 → many
    V(359562-360314) YER100W
    soybean
    (Glycine max)
    eudicotyledons BG839296.12   -- 70.62(n)    BG839296.1 


    ENSEMBL Gene Tree for UBE2J1 (if available)
    TreeFam Gene Tree for UBE2J1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2J1 gene
    UBE2J22  
    1 SIMAP similar gene for UBE2J1 using alignment to 1 protein entry:     UB2J1_HUMAN:
    UBE2J2

    Find genes that share paralogs with UBE2J1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2J1 (see all 544)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817057371,2
    --90036005(+) CCCCAA/GAGGCA 1 -- ds50010--------
    rs122003751,2
    C,H--90036019(+) GCTGAG/AGTCTG 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 412
    rs1392392681,2
    --90036118(+) AGAAGA/GGATCA 1 -- ds50010--------
    rs1867768841,2
    --90036240(+) TGCCTA/CGTTAG 1 -- ds50010--------
    rs1499914161,2
    --90036280(+) TAGGAC/GGTAGA 1 -- ds50010--------
    rs794564251,2
    C,F--90036328(+) AACCTT/CTGGTC 1 -- ds50011Minor allele frequency- C:0.23WA 118
    rs1912696231,2
    --90036485(+) ATTAGC/TCTTTG 1 -- ut310--------
    rs132154181,2
    C,F,H--90036511(+) AAATGC/TATTAA 1 -- ut31 ese330Minor allele frequency- T:0.21EA NA NS 3214
    rs1476902051,2
    --90036550(+) ACATAC/GGCTTT 1 -- ut310--------
    rs792826361,2
    C--90036631(+) TCTGAT/CCTATA 1 -- ut312Minor allele frequency- C:0.10NA 122

    HapMap Linkage Disequilibrium report for UBE2J1 (90036344 - 90062619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2J1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv27467CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing UBE2J1
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2J1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with UBE2J1           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: UBE2J1 (1 document)

    Export disorders for UBE2J1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2J1 gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with UBE2J1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of non-canonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. (PubMed id 10708578)1, 2, 3, 9 Lester D.H.... Houston B. (Biochem. Biophys. Res. Commun. 2000)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    4. A role for mammalian Ubc6 homologues in ER-associated protein degradation. (PubMed id 12082160)1, 2 Lenk U....Sommer T. (J. Cell Sci. 2002)
    5. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    6. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    7. A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. (PubMed id 20222955)1, 9 Pattaro C....Pramstaller P.P. (BMC Med. Genet. 2010)
    8. Endoplasmic reticulum-associated ubiquitin-conjugating enzyme Ube2j1 is a novel substrate of MK2 (MAPKAP kinase-2) involved in MK2-mediated TNFI+ production. (PubMed id 24020373)1 Menon M.B....Gaestel M. (Biochem. J. 2013)
    9. Unassembled CD147 is an endogenous endoplasmic reticulum-associated degradation substrate. (PubMed id 23097496)1 Tyler R.E....Kopito R.R. (Mol. Biol. Cell 2012)
    10. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PubMed id 22607976)2 Sato T.... Kai H. (Mol. Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51465 HGNC: 17598 AceView: UBE2J1 Ensembl:ENSG00000198833 euGenes: HUgn51465
    ECgene: UBE2J1 Kegg: 51465 H-InvDB: UBE2J1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2J1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2J1 gene:
    Search GeneIP for patents involving UBE2J1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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