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Aliases for UBE2J1 Gene

Aliases for UBE2J1 Gene

  • Ubiquitin Conjugating Enzyme E2 J1 2 3 5
  • Ubiquitin-Conjugating Enzyme E2, J1 (UBC6 Homolog, Yeast) 2 3
  • Yeast Ubiquitin-Conjugating Enzyme UBC6 Homolog E 3 4
  • Non-Canonical Ubiquitin-Conjugating Enzyme 1 3 4
  • E2 Ubiquitin-Conjugating Enzyme J1 3 4
  • HSUBC6e 3 4
  • NCUBE-1 3 4
  • NCUBE1 3 4
  • Ubiquitin-Conjugating Enzyme E2, J1, U 3
  • Ubiquitin-Conjugating Enzyme E2, J1 2
  • Ubiquitin-Conjugating Enzyme E2 J1 3
  • EC 2.3.2.23 4
  • HSU93243 3
  • HSPC153 3
  • HSPC205 3
  • CGI-76 3
  • UBC6E 3
  • Ubc6p 3
  • UBC6 3

External Ids for UBE2J1 Gene

Previous GeneCards Identifiers for UBE2J1 Gene

  • GC06M090003
  • GC06M090032
  • GC06M090031
  • GC06M090093
  • GC06M087253
  • GC06M090037

Summaries for UBE2J1 Gene

Entrez Gene Summary for UBE2J1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2J1 Gene

UBE2J1 (Ubiquitin Conjugating Enzyme E2 J1) is a Protein Coding gene. Among its related pathways are Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway and Innate Immune System. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2J2.

UniProtKB/Swiss-Prot for UBE2J1 Gene

  • Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Gene Wiki entry for UBE2J1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2J1 Gene

Genomics for UBE2J1 Gene

Regulatory Elements for UBE2J1 Gene

Enhancers for UBE2J1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G089345 2 FANTOM5 Ensembl ENCODE dbSUPER 18.5 +2.6 2645 8.6 HDGF PKNOX1 CREB3L1 WRNIP1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SLC30A9 UBE2J1 SRSF12 RRAGD GABRR2 TUBB3P1 PNRC1 RNGTT GABRR1 GC06M089320
GH06G089078 1.7 Ensembl ENCODE dbSUPER 10.5 +271.5 271525 5.7 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 SRSF12 CASP8AP2 PM20D2 UBE2J1 PNRC1 GC06P089091
GH06G089033 1.7 FANTOM5 Ensembl ENCODE 7.1 +317.0 316994 4.2 PKNOX1 FOXA2 ATF1 ARNT ARID4B SIN3A FEZF1 DMAP1 BRCA1 ZNF48 PNRC1 CASP8AP2 SRSF12 RNGTT UBE2J1 RRAGD GC06M089046 PIR60881
GH06G089816 1.1 ENCODE 10.4 -466.1 -466072 4.1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 UBE2J1 MDN1 LYRM2 GC06P089815 GC06P089820
GH06G089044 1.1 FANTOM5 Ensembl ENCODE 9.5 +307.8 307837 1.6 PAF1 SPI1 TCF7L2 PNRC1 UBE2J1 RNGTT RRAGD GC06M089046 PIR60881
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2J1 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2J1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000199889 1000 3001 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B SLC30A9 ZNF766

Genomic Location for UBE2J1 Gene

Chromosome:
6
Start:
89,326,625 bp from pter
End:
89,352,900 bp from pter
Size:
26,276 bases
Orientation:
Minus strand

Genomic View for UBE2J1 Gene

Genes around UBE2J1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2J1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2J1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2J1 Gene

Proteins for UBE2J1 Gene

  • Protein details for UBE2J1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y385-UB2J1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 J1
    Protein Accession:
    Q9Y385
    Secondary Accessions:
    • A8K3F9
    • Q53F25
    • Q5W0N4
    • Q9BZ32
    • Q9NQL3
    • Q9NY66
    • Q9P011
    • Q9P0S0
    • Q9UF10

    Protein attributes for UBE2J1 Gene

    Size:
    318 amino acids
    Molecular mass:
    35199 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD34071.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF36125.1; Type=Frameshift; Positions=119; Evidence={ECO:0000305};

neXtProt entry for UBE2J1 Gene

Post-translational modifications for UBE2J1 Gene

  • Ubiquitination at isoforms=186
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2J1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UBE2J1 Gene

Domains & Families for UBE2J1 Gene

Gene Families for UBE2J1 Gene

Protein Domains for UBE2J1 Gene

Suggested Antigen Peptide Sequences for UBE2J1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y385

UniProtKB/Swiss-Prot:

UB2J1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2J1: view

Function for UBE2J1 Gene

Molecular function for UBE2J1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Enzyme Numbers (IUBMB) for UBE2J1 Gene

Gene Ontology (GO) - Molecular Function for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11439185
GO:0061630 ubiquitin protein ligase activity IBA --
GO:0061631 ubiquitin conjugating enzyme activity IMP 21245296
genes like me logo Genes that share ontologies with UBE2J1: view
genes like me logo Genes that share phenotypes with UBE2J1: view

Animal Models for UBE2J1 Gene

MGI Knock Outs for UBE2J1:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2J1

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2J1 Gene

Localization for UBE2J1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2J1 Gene

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2J1 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 4
plasma membrane 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with UBE2J1: view

Pathways & Interactions for UBE2J1 Gene

genes like me logo Genes that share pathways with UBE2J1: view

UniProtKB/Swiss-Prot Q9Y385-UB2J1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2J1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
GO:0016567 protein ubiquitination IEA --
GO:0018279 protein N-linked glycosylation via asparagine IMP 22607976
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 21245296
GO:0042534 regulation of tumor necrosis factor biosynthetic process IEA --
genes like me logo Genes that share ontologies with UBE2J1: view

No data available for SIGNOR curated interactions for UBE2J1 Gene

Drugs & Compounds for UBE2J1 Gene

(3) Drugs for UBE2J1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2J1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2J1: view

Transcripts for UBE2J1 Gene

mRNA/cDNA for UBE2J1 Gene

Unigene Clusters for UBE2J1 Gene

Ubiquitin-conjugating enzyme E2, J1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2J1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - -
SP2: -
SP3:
SP4: - -
SP5: -

Relevant External Links for UBE2J1 Gene

GeneLoc Exon Structure for
UBE2J1
ECgene alternative splicing isoforms for
UBE2J1

Expression for UBE2J1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2J1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2J1 Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for UBE2J1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (26.1) and Stomach (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2J1 Gene



Protein tissue co-expression partners for UBE2J1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2J1 Gene:

UBE2J1

SOURCE GeneReport for Unigene cluster for UBE2J1 Gene:

Hs.163776

Evidence on tissue expression from TISSUES for UBE2J1 Gene

  • Liver(4.3)
  • Spleen(4.3)
  • Blood(4.2)
  • Muscle(4.2)
  • Nervous system(2.7)
  • Lung(2.4)
genes like me logo Genes that share expression patterns with UBE2J1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2J1 Gene

Orthologs for UBE2J1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2J1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2J1 34 35
  • 99.69 (n)
cow
(Bos Taurus)
Mammalia UBE2J1 34 35
  • 93.19 (n)
dog
(Canis familiaris)
Mammalia UBE2J1 34 35
  • 92.26 (n)
rat
(Rattus norvegicus)
Mammalia Ube2j1 34
  • 91.55 (n)
mouse
(Mus musculus)
Mammalia Ube2j1 34 16 35
  • 88.16 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 83 (a)
OneToMany
-- 35
  • 76 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2J1 35
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2J1 34 35
  • 73.8 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2J1 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2j1 34
  • 70.47 (n)
zebrafish
(Danio rerio)
Actinopterygii ube2j1 34 35
  • 61.08 (n)
Dr.28798 34
worm
(Caenorhabditis elegans)
Secernentea ubc-6 34 35
  • 60.43 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC6 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1220 35
  • 55 (a)
OneToOne
Species where no ortholog for UBE2J1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2J1 Gene

ENSEMBL:
Gene Tree for UBE2J1 (if available)
TreeFam:
Gene Tree for UBE2J1 (if available)

Paralogs for UBE2J1 Gene

Paralogs for UBE2J1 Gene

(1) SIMAP similar genes for UBE2J1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBE2J1: view

Variants for UBE2J1 Gene

Sequence variations from dbSNP and Humsavar for UBE2J1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000156728 -- 89,335,155(+) ACCAC(A/G)GAAAT intron-variant
rs1000196542 -- 89,344,966(+) AACAT(A/G)TCAGG intron-variant
rs1000354521 -- 89,338,800(+) AGCTG(C/G)AACTA intron-variant
rs1000363611 -- 89,348,085(+) CAGCA(C/T)AGTCT intron-variant
rs1000370911 -- 89,340,931(+) CCACC(A/G)CGCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2J1 Gene

Variant ID Type Subtype PubMed ID
esv27467 CNV loss 19812545
esv3890901 CNV gain 25118596
nsv1027007 CNV gain 25217958

Variation tolerance for UBE2J1 Gene

Residual Variation Intolerance Score: 67.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2J1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2J1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2J1 Gene

Disorders for UBE2J1 Gene

Relevant External Links for UBE2J1

Human Genome Epidemiology (HuGE) Navigator
UBE2J1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2J1

No disorders were found for UBE2J1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2J1 Gene

Publications for UBE2J1 Gene

  1. Identification of a family of non-canonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. (PMID: 10708578) Lester D.H. … Houston B. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 22 64
  2. STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein. (PMID: 22607976) Sato T. … Kai H. (Mol. Cell 2012) 3 4 64
  3. A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level. (PMID: 20222955) Pattaro C. … Pramstaller P.P. (BMC Med. Genet. 2010) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64

Products for UBE2J1 Gene

Sources for UBE2J1 Gene

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