UBE2I Gene
protein-coding GIFtS: 72
GCID: GC16P001359
|
|
ubiquitin-conjugating enzyme E2I(Previous names: ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9),...)
| |
Aliases
for UBE2I gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2I1 2 | | SUMO-Conjugating Enzyme UBC92 | | UBC91 2 3 | | Ubiquitin Conjugating Enzyme 92 | | Ubiquitin-Conjugating Enzyme E2I (Homologous To Yeast UBC9)1 2 | | Ubiquitin-Conjugating Enzyme UbcE2A2 | | Ubiquitin-Conjugating Enzyme E2I (UBC9 Homolog, Yeast)1 2 | | Ubiquitin-Like Protein SUMO-1 Conjugating Enzyme2 | | Ubiquitin Carrier Protein 92 3 | | Ubiquitin-Protein Ligase E2I2 | | Ubiquitin Carrier Protein I2 3 | | EC 6.3.2.-3 | | Ubiquitin-Protein Ligase I2 3 | | UBCE93 | | SUMO-Protein Ligase2 3 | | P182 | | C358B7.12 | | Ubiquitin-Conjugating Enzyme E2 I3 | | P182 | | EC 6.3.28 | | SUMO-1-Protein Ligase2 | | |
Export aliases for UBE2I gene to outside databasesPrevious GC identifers: GC16P001375 GC16P001299 GC16P001287 |
Summaries
for UBE2I gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2I:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, orE1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of theE2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein havebeen found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex andcatalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Cancatalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nucleararchitecture and chromosome segregation
Gene Wiki entry for UBE2I
|
Genomic Views
for UBE2I gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2I gene promoter:
AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2I
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2I |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3UBE2I Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P001359: view genomic region
(about GC identifiers)
Start:
|
1,355,548 bp from pter |
End:
|
1,377,019 bp from pter |
Size:
|
21,472 bases |
Orientation:
|
plus strand |
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Proteins
for UBE2I gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279 (See
protein sequence)Recommended Name: SUMO-conjugating enzyme UBC9 Size: 158 amino acids; 18007 Da
Subunit: Interacts with HIPK1, HIPK2, PPM1J, RASD2 and TCF3 Interacts with NR2C1; the interaction promotes itssumoylation (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP. Interactswith various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with RWDD3; theinteraction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B. Interacts with DNMT1.Interacts with FOXL2. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Interacts with humanherpesvirus 6 IE2. Interacts with human adenovirus early E1A protein; this interaction interferes with polysumoylation(Probable). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainlyin its B domain. Interacts with PML-RARA oncoprotein (via the coiled-colied domain); the interaction is required forsumoylation of the PML-RARA oncoprotein. Interacts with IPO13. Interacts with NFATC2IP; this inhibits formation ofpoly-SUMO chains. Interacts with FHIT
Subcellular location: Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes.Recruited by BCL11A into the nuclear body (By similarity)
Sequence caution: Sequence=AAH51289.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAD92225.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/17 PDB 3D structures from  and Proteopedia  for UBE2I (see all 17):1A3S (3D)
1KPS (3D)
1Z5Q (3D)
1Z5S (3D)
2GRN (3D)
2GRO (3D)
Secondary accessions: D3DU69 P50550 Q15698 Q59GX1 Q86VB3Explore the universe of human proteins at neXtProt for UBE2I: NX_P63279
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P63279
4/6 DME Specific Peptides for UBE2I (P63279) (see all 6)
UBE2I Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_003336.1 NP_919235.1 NP_919236.1 NP_919237.1
ENSEMBL proteins: ENSP00000348056 ENSP00000324897 ENSP00000380649 ENSP00000380650 ENSP00000456188 ENSP00000385009 ENSP00000457064 ENSP00000384568 ENSP00000455893 ENSP00000384361 ENSP00000455252 Reactome Protein details: P63279
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
UBE2I for ontologies About GeneDecksing
UBE2I Antibody Products:
Assay Products for UBE2I: |
Protein
Domains /
Families
for UBE2I gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2I for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P63279ProtoNet protein and cluster: P63279 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function
for UBE2I gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex andcatalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Cancatalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nucleararchitecture and chromosome segregationCatalytic activity: ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine Genatlas biochemistry entry for UBE2I:ubiquitin conjugating enzyme E2I,homolog to yeast UBC9,associating with RAD51,RAD52 proteins in the double strandRAD51/RAD52 repair pathway,also associating with UBL1 and PT53,involved in DNA recombination and essential forcell-cycle progression
Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2I (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2I (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): UBE2I (NM_003345) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2I | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2I |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2I |
Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11): About this table
UBE2I for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for UBE2I:
Animal Models:
Mouse knock-out Ube2itm1.1Adej for UBE2I
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Ube2i):
UBE2I for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBE2I gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Meiotic Synapsis | | | 2 | Proteolysis Putative SUMO-1 pathway | | | 3 | DNA damage Role of SUMO in p53 regulation | | | 4 | Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF) | | | 5 | Protein Stability | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for UBE2I
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2I (see all 6)
1 
Cell Signaling Technology (CST) Pathway for UBE2I
3  GeneGo (Thomson Reuters) Pathways for UBE2I
5/8  BioSystems Pathways for UBE2I (see all 8)
5 
Reactome Pathways for UBE2I
2 
Kegg Pathways (Kegg details for UBE2I):
UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279Pathway: Protein modification; protein sumoylation
UBE2I for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2I
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/379 Interacting proteins for UBE2I (P632791, 2, 3 ENSP000003248974) via UniProtKB, MINT, STRING, and/or I2D (see all 379)
About this table
Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table
UBE2I for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2I gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
UBE2I for compounds About GeneDecksing
 Browse Tocris compounds for UBE2I
4 HMDB Compounds for UBE2I About this table
7 Novoseek chemical compound relationships for UBE2I gene About this table
2 PharmGKB related drug/compound annotations for UBE2I geneAbout this table
Search CenterWatch for drugs/clinical trials and news about UBE2I / UBC9
|
Transcripts
for UBE2I gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE2I gene (4 alternative transcripts): NM_003345.4 NM_194259.2 NM_194260.2 NM_194261.2 Unigene Cluster for UBE2I: Ubiquitin-conjugating enzyme E2I Hs.302903 [show with all ESTs]Unigene Representative Sequence: NM_19425918/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20): ENST00000339021 ENST00000355803(uc002cld.2) ENST00000325437(uc002clc.2)
ENST00000397514(uc002clg.2) ENST00000397515(uc002clf.2) ENST00000473256(uc002cle.2)
ENST00000568288 ENST00000567383 ENST00000403747 ENST00000568209 ENST00000562482
ENST00000566587 ENST00000406620 ENST00000562470 ENST00000567074 ENST00000402301(uc002clh.1 uc002cli.1)
ENST00000566775 ENST00000566159
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2I (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2I (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): UBE2I (NM_003345) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2I | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2I |
Additional cDNA sequence: AB208988.1 AJ002385.1 AK291118.1 BC000427.2 BC004429.1 BC051289.1 BC064492.1 BT006932.1 BT007010.1 D45050.1 U29092.1 U31882.1 U31933.1 U38785.1 U45328.1 U66818.1 X96427.1 24 DOTS entries: DT.452937 DT.220036 DT.100802787 DT.100802786 DT.91758126 DT.95263931 DT.91758135 DT.75112535 DT.95263936 DT.91758122 DT.120698929 DT.91758123 DT.95323948 DT.100802788 DT.91758153 DT.95221080 DT.100802782 DT.40117461 DT.87078190 DT.95263930 DT.95263933 DT.97774979 DT.97787746 DT.97860318 24/495 AceView cDNA sequences (see all 495): NM_003345 BQ688282 BQ688212 BC000427 BU146357 AI769031 BU660728 NM_194259 CR590087 AA148406 AA297526 AA296848 AI815957 BU072841 AI127982 BM552837 CR603776 BE388002 AA662426 BI050327 AA923033 NM_194260 BG433668 BU726898
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2I (see all 14) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | · | 11e |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBE2I
|
Expression
for UBE2I gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2I expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTCTCACCG
About this image
See UBE2I Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2I
SOURCE GeneReport for Unigene cluster: Hs.302903
UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279Tissue specificity: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Alsoexpressed in testis and thymus
SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2I:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2I
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2I | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2I | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2I | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2I |
Orthologs
for UBE2I gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2I gene from 9/39 species (see all 39) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
UBE2I1 |
ubiquitin-conjugating enzyme E2I |
87.13(n)
100(a) |
|
374123 NM_204265.1 NP_989596.1 |
lizard
(Anolis carolinensis) |
Reptilia |
UBE2I6 |
-- |
100(a) |
1 ↔ 1 |
GL343612.1(249414-260071) |
African clawed frog
(Xenopus laevis) |
Amphibia |
ube2i-prov2 |
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) |
86.8(n) |
|
BC046273.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
BC058302.12 |
-- |
83.54(n) |
|
114445 BC058302.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
lwr1 , 3 |
female meiosis protein tagging3
lesswright1 |
86(a)3
71.15(n)1
86.54(a)1 |
|
2 21D13
332261 NM_057630.31 NP_476978.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
ubc-93 |
ubiquitin-conjugating enzyme |
76(a) |
|
IV(4651090-4652133) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UBC9(YDL064W)4
UBC91 |
SUMO-conjugating enzyme involved in the Smt3p conjugation more4
Ubc9p1 |
54.91(n)1
56.41(a)1 |
|
4(337487-338070)4
8514951, 4 NP_010219.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SCE11 |
SUMO-conjugating enzyme SCE1 |
62.77(n)
66.23(a) |
|
824956 NM_115649.2 NP_191346.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.90192 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
74.99(n) |
|
AK105227.1 |
ENSEMBL Gene Tree for UBE2I (if available)
TreeFam Gene Tree for UBE2I (if available) |
Paralogs
for UBE2I gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE2I gene
18/25 SIMAP similar genes for UBE2I using alignment to 6 protein entries: UBC9_HUMAN (see all proteins)
(see all similar genes):HR6A UBE2A UBE2E3 UBE2N UBE2D3 UBE2B
UBE2E2 UBE2M UBE2D2 UBE2NL UBE2E1 UBE2S
UBE2H UBE2D4 UBE2D1 CDC34 UBE2L6 UBE2T
UBE2I for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for UBE2I
PGOHUM00000240610
|
Genomic Variants
for UBE2I gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBE2I (1355548 - 1377019 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for UBE2I
6 CNVs: 5811 29991 72417 4915 5329 29995
Human Gene Mutation Database (HGMD): UBE2I
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2I |
|
Disorders
/ Diseases
for UBE2I gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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UBE2I for disorders About GeneDecksing
OMIM gene information: 601661
OMIM disorders: --
20/33  diseases for UBE2I (see all 33): About MalaCardsdna topoisomerase i severe acute respiratory syndrome cortisol resistance squamous cell carcinoma of the head and neck
squamous cell carcinoma megakaryoblastic leukemia rett syndrome werner syndrome
kaposi's sarcoma wilms tumor cblc microphthalmia
parkinson's disease ischemia hematopoiesis sarcoma
carcinoma ovarian cancer retinoblastoma influenza
10 Novoseek disease relationships for UBE2I gene About this table
Human Genome Epidemiology (HuGE) Navigator: UBE2I (5 documents)
Export disorders for UBE2I gene to outside databases
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Publications
for UBE2I gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for UBE2I gene, integrated from 9 sources (see all 357):
(articles sorted by number of sources associating them with UBE2I) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. (PubMed id 8565643)1, 2, 3, 9 Watanabe T.K.... Shin S. (1996)
- Ubc9 interacts with the androgen receptor and activates receptor- dependent transcription. (PubMed id 10383460)1, 2, 9 Poukka H.... Jaenne O.A. (1999)
- Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation. (PubMed id 17005699)1, 2, 9 Tomoiu A.... Flamand L. (2006)
- Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. (PubMed id 12924945)1, 2, 9 Tatham M.H.... Chen Y. (2003)
- Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction. (PubMed id 17466333)1, 2, 9 Capili A.D. and Lima C.D. (2007)
- Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. (PubMed id 15608651)1, 2, 9 Tatham M.H.... Hay R.T. (2005)
- Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9- Nup358 complex. (PubMed id 15931224)1, 2, 9 Reverter D. and Lima C.D. (2005)
- Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9. (PubMed id 11085938)1, 2, 9 Shi Y....Paterson M.C. (2000)
- Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9. (PubMed id 9197546)1, 2, 9 Masson M....Niedergang C.P. (1997)
- Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9. (PubMed id 8668529)1, 2, 9 Yasugi T. and Howley P.M. (1996)
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External Searches for UBE2I gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
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Genome Databases showing UBE2I gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
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Other Databases showing UBE2I gene
(According to HUGE)
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| -- |
Specialized Databases showing UBE2I gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for UBE2I gene:
Search GeneIP for patents involving UBE2I
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2I gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for UBE2I | | OriGene shRNA RFP for UBE2I | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2I | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2I | | | OriGene Protein Over-expression Lysate for UBE2I | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for UBE2I | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2I | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2I | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBE2I | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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