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UBE2I Gene

protein-coding GIFtS: 69

GC16P001299

ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
(Previous name: ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C358B7.1 ^²
EC 6.3.2.- ^³
P18 ^²
UBC9 ^¹, ², ³
UBCE9 ^³
p18 ^³

Descriptions
SUMO-1-protein ligase ^²
SUMO-protein ligase ^³
Ubiquitin carrier protein 9 ^³
Ubiquitin carrier protein I ^³
Ubiquitin-conjugating enzyme E2 I ^³
Ubiquitin-protein ligase I ^³
ubiquitin carrier protein ^²
ubiquitin conjugating enzyme 9 ^²
ubiquitin-conjugating enzyme E2I ^²
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) ^²
ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9) ^¹, ²
ubiquitin-conjugating enzyme UbcE2A ^²
ubiquitin-like protein SUMO-1 conjugating enzyme ^²
ubiquitin-protein ligase E2I ^²

External Ids
HGNC: 12485¹
Entrez Gene: 7329²
UniProtKB: P63279³
Ensembl: ENSG00000103275⁷

Search outside databases for aliases for UBE2I gene

Previous GC identifer: GC16P001375

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2I:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. Four alternatively spliced transcript variants encoding the same protein have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279

Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B

E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase

such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation

Gene Wiki entry for UBE2I

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2I gene

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

UBE2I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P001299: (about GC identifiers)

Start:	1,299,181 bp from pter
End:	1,315,391 bp from pter
Size:	16,211 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_037887.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279 (See protein sequence)

Recommended Name: SUMO-conjugating enzyme UBC9

Size: 158 amino acids; 18007 Da

Subunit: Interacts with HIPK1, HIPK2 and PPM1J (By similarity). Forms a tight complex with RANGAP1

and RANBP2. Interacts with SIAH1 and PARP. Interacts with various transcription factors such as

TCF3, TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with human adenovirus E1A and human

herpesvirus 6 IE2. Interacts with RWDD3; the interaction enhances the sumoylation of a number of

proteins such as HIF1A and I-kappa-B

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1A3S (3D)

1KPS (3D)

1Z5Q (3D)

1Z5S (3D)

2GRN (3D)

2GRO (3D)

2GRP (3D)

2GRQ (3D)

2GRR (3D)

2O25 (3D)

2PE6 (3D)

2PX9 (3D)

Secondary accessions: P50550 Q15698 Q59GX1 Q86VB3

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_003336.1 NP_919235.1 NP_919236.1 NP_919237.1

ENSEMBL proteins:

ENSP00000384361 ENSP00000385009 ENSP00000384568 ENSP00000324897 ENSP00000348056 ENSP00000380650

ENSP00000380649

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2I
	Recombinant Proteins from Abcam (UBE2I / UBC9)
	Human Recombinant Proteins from Abnova (UBE2I)

OriGene Purified Recombinant Human Protein: UBE2I

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000795	synaptonemal complex	TAS	8610150
GO:0005634	nucleus	IEA	--
GO:0016605	PML body	IDA	9885291

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Antibodies for UBE2I:

	Invitrogen Antibodies for UBE2I
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE2I
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for UBE2I (ubc9)
	Antibodies from Abcam (UBE2I / UBC9), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2I)
	Novus Biologicals Antibodies for UBE2I

Assays for UBE2I:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2I

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P63279

ProtoNet protein and cluster: P63279

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2I)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_194259

Applied Biosystems Silencer® siRNAs for UBE2I

Sigma-Aldrich siRNA and siRNA Panels for UBE2I

Sigma-Aldrich shRNA Panels and shRNA for UBE2I

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_003345
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_003345
untagged cDNA clones in CMV expression vector (see all 5): BC000744

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC000744

UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279

Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B

E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase

such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation

Catalytic activity: ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine

Enzyme Number (IUBMB): EC 6.3.2.-

Genatlas biochemistry entry for UBE2I:

ubiquitin conjugating enzyme E2I,homolog to yeast UBC9,associating with RAD51,RAD52 proteins in the

double strand RAD51/RAD52 repair pathway,also associating with UBL1 and PT53,involved in DNA

recombination and essential for cell-cycle progression

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ube2i):

embryogenesis

hematopoietic system

lethality-prenatal/perinatal

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	9885291 12072434 14516784
GO:0016566	specific transcriptional repressor activity	IDA	16631117
GO:0016874	ligase activity	IEA	--
GO:0019787	small conjugating protein ligase activity	IEA	--
GO:0043398	HLH domain binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2I (Your Favorite Gene powered by Ingenuity)

Glucocorticoid Receptor Signaling
Hypoxia Signaling in the Cardiovascular System
Protein Ubiquitination Pathway

GeneDecks UBE2I for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279

Pathway: Protein modification; protein sumoylation

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2I

5/106 Interacting proteins for UBE2I (ENSP00000348056³ P63279^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 106 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SUMO1P3	P63165¹^,²	EBI-80168, EBI-80140 MINT-4958422 MINT-4958436 MINT-4958452
RANBP2	P49792¹	STRING (score=.999) EBI-80168, EBI-973138
RWDD3	Q9Y3V2¹	STRING (score=.84) EBI-80168, EBI-1549885
SAE1	Q9UBE0¹	STRING (score=.86) EBI-80168, EBI-743154
UBA1	P22314¹	STRING (score=.815) EBI-80168, EBI-709688

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	8565643
GO:0007049	cell cycle	IEA	--
GO:0007059	chromosome segregation	IEA	--
GO:0007067	mitosis	IEA	--
GO:0043687	post-translational protein modification	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2I
4 Novoseek chemical compound relationships for UBE2I gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	65.43	6	16029420 (1), 19107417 (1), 17336575 (1), 15272016 (1) (see all 5)
atp	0.00	2	16275321 (1)
glucose	0.00	9	17536066 (3), 16296343 (3), 16955077 (1)
steroid	0.00	1	10383460 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2I)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_194259

Sigma-Aldrich siRNA and siRNA Panels for UBE2I

Sigma-Aldrich shRNA Panels and shRNA for UBE2I

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003345 NM_194259 NM_194260 NM_194261

REFSEQ mRNAs for UBE2I gene (4 alternative transcripts):

NM_003345.3 NM_194259.1 NM_194260.1 NM_194261.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003345 NM_194259 NM_194260 NM_194261

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_003345
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_003345
                                 untagged cDNA clones in CMV expression vector (see all 5): BC000744

Additional cDNA sequence:

AB208988.1 AJ002385.1 AK291118.1 BC000427.2 BC004429.1 BC051289.1 BC064492.1 BC069256.1

BT006932.1 BT007010.1 CR590087.1 CR603776.1 CR604763.1 D45050.1 U29092.1 U31882.1

U31933.1 U38785.1 U45328.1 U66818.1 U66867.1 X96427.1

24/25 DOTS entries (see all 25 ):

DT.452937 DT.220036 DT.100802787 DT.91758126 DT.100802786 DT.95263931 DT.95323948 DT.91758135

DT.75112535 DT.91758122 DT.95263936 DT.100009715 DT.100802782 DT.120698929 DT.91758123 DT.95221080

DT.100802788 DT.91758153 DT.97787746 DT.40117461 DT.87078190 DT.95263930 DT.95263933 DT.97774979

24/495 AceView cDNA sequences (see all 495 ):

AA923033 AA296848 AA053574 BU539585 BQ688282 NM_194260 BM552837 BQ953214

AA662426 NM_003345 CR603776 NM_194261 AI815957 CR604763 BG433668 AA148406

AI127982 BU072841 BE388002 BM995373 CR590087 BC004429 BU146357 AA297526

highest scoring ESTs for UBE2I:

U45328 U66867 AA022726 AA022818 AA026425 AA026520 AA053263 AA074487 AA074616 AA076078

Unigene Cluster for UBE2I:

Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)

Hs.302903 [show with all ESTs]

Unigene Representative Sequence: BC069256

GeneLoc Exon Structure

5/14 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2I (see all 14 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	·	4d	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d	·	11e
SP1:							-		-		-		-		-		-								-						-		-		-
SP2:					-		-		-		-		-		-		-								-						-		-		-
SP3:									-		-						-								-						-		-		-
SP4:									-		-		-		-		-								-						-		-		-
SP5:									-		-		-		-		-								-						-		-		-

About this scheme

ECgene alternative splicing isoforms for UBE2I

7 Ensembl transcripts including schematic representations:

ENST00000402301 ENST00000403747 ENST00000406620 ENST00000325437 ENST00000355803 ENST00000397515

ENST00000397514

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2I expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2I

¹ / ² / ³

13 probe-sets matching UBE2I gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
838_s_at²^{, 3}	U95-A	1	1.00	1.00	0.94	1.12	U45328	1.00	1.00	1.00	1
38480_s_at²^{, 3}	U95-A	1	1.00	1.00	0.92	1.15	U66867	1.00	1.00	1.00	1
80662_at²^{, 3}	U95-E	1	1.00	1.00	0.00	0.18	AI816030	0.80	1.00	0.91	1
33136_at*²^{, 3}	U95-A	1	1.00	1.00	0.53	0.72	AL031714	0.20	1.00	0.72	1
233360_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK024172	0.20	1.00	0.72	1
211008_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC000744	0.40	1.00	0.76	1
213535_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	AA910614	0.40	1.00	0.76	1
208760_at*²^{, 3}	U133-A	1	1.00	1.00	--	--	AL031714	0.20	1.00	0.72	1
233360_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1558088_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211008_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213535_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--
208760_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTCTCACCG

SOURCE GeneReport for Unigene cluster: Hs.302903
Expression variation in blood from EXPOLDB for UBE2I
UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279
Tissue specificity: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta
and brain. Also expressed in testis and thymus

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2I gene from 5/25 species (see all 25 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2I¹	--	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	91.98(n) 100(a)	491332 XM_548453.2 XP_548453.2
chimpanzee (Pan troglodytes)	UBE2I¹	--	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	98.95(n) 100(a)	749975 XM_001172559.1 XP_001172559.1
cow (Bos taurus)	UBE2I¹	--	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	90.72(n) 100(a)	515573 XM_001252935.1 XP_001252936.1
rat (Rattus norvegicus)	Ube2i¹	--	ubiquitin-conjugating enzyme E2I	89.24(n) 100(a)	25573 NM_013050.1 NP_037182.1
mouse (Mus musculus)	Ube2i^{1, 5}	17⁵	ubiquitin-conjugating enzyme E2I^{1, 5}	89.24(n)¹ 100(a)¹	22196¹ NM_011665.3¹ NP_035795.1¹ AI607556⁵ AI666653⁵ (see all 46)

About this table Species with no ortholog for UBE2I

ENSEMBL Gene Tree for UBE2I

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2I gene

UBE2L6² UBE2S² UBE2L3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/174 NCBI SNPs in UBE2I are shown (see all 174 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 91)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs8063^1,2	A,C,F,H	1314819(+)	`CGTCAG/AAAGGA`	4	--	ut3¹ trp³		14		MN EU EA WA NA	1282
	rs7302^1,2	A,C,F,H	1315264(+)	`CCAGGG/TCAGCA`	4	--	ut3¹ ese³		12		MN NA EU EA WA	1162
	rs8050313^1,2	C,F,H	1315564(+)	`CATCTT/GCGGGC`	4	--	ng3¹		4		EU EA WA	410
--	rs9328917^1,2	A,C	1297227(+)	`CAGGTA/GTCTAG`	1	--	ng5¹		0	--	--	--	--
	rs9597^1,2	F,H	1314952(+)	`GGTCTC/GGATTC`	4	--	ut3¹		5		MN EU EA WA	600
	rs12102342^1,2	F,H	1302557(+)	`CCTTCG/ATCCGT`	4	--	int¹ ut5¹		3		EU EA	294
	rs12444610^1,2	H	1315682(+)	`CAGGGC/GTGGGG`	4	--	ng3¹		4		EU EA WA	386
--	rs4610^1,2	C,F	1304366(+)	`ATTCCA/GGGAAA`	4	P/P	syn¹ ese³ trp³		6		MN EU EA WA NA	516
	rs12446893^1,2	A,C,F,H	1311296(+)	`TGAGGA/GGGTCT`	4	--	int¹ ese³		4		EU EA WA	410
	rs8053875^1,2	A,C,F,H	1312164(+)	`CTGGCG/CTGCTG`	4	--	int¹		4		EU EA WA	396

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HapMap Linkage Disequilibrium images for UBE2I (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601661

10 Novoseek disease relationships for UBE2I gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
adenocarcinoma lung	20.12	3	16300471 (1), 16758298 (1)
shock	7.35	1	9514881 (1)
melanoma	6.64	5	17297476 (2), 16300471 (1), 16758298 (1)
ovarian carcinoma	5.71	3	16300471 (1), 16758298 (1)
insulin sensitivity	0.00	1	17536066 (1)
cancer	0.00	3	16300471 (2)
tumors	0.00	9	15735760 (3), 15087395 (3), 16758298 (1)
leukemia	0.00	1	14739995 (1)
carcinoma squamous cell	0.00	1	17970065 (1)
ischemia	0.00	2	16955077 (1), 12415119 (1)

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Human Genome Epidemiology Navigator: UBE2I (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/217 PubMed articles for UBE2I gene (see all 217 ):

Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. (PubMed id 8565643)^{1, 2, 3, 4} Watanabe T.K.... Shin S. (1996)
Ubc9 interacts with the androgen receptor and activates receptor- dependent transcription. (PubMed id 10383460)^{1, 3, 4} Poukka H.... Jaenne O.A. (1999)
Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation. (PubMed id 17005699)^{1, 3, 4} Tomoiu A.... Flamand L. (2006)
Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. (PubMed id 12924945)^{1, 3, 4} Tatham M.H.... Chen Y. (2003)
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. (PubMed id 15608651)^{1, 3, 4} Tatham M.H.... Hay R.T. (2005)
Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9- Nup358 complex. (PubMed id 15931224)^{1, 3, 4} Reverter D. and Lima C.D. (2005)
Poly(ADP-ribose) polymerase interacts with a novel human ubiquitin conjugating enzyme: hUbc9. (PubMed id 9197546)^{1, 3, 4} Masson M....Niedergang C.P. (1997)
Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. (PubMed id 8610150)^{1, 3, 4} Kovalenko O.V.... Golub E.I. (1996)
Molecular cloning of the cDNA and chromosome localization of the gene for human ubiquitin-conjugating enzyme 9. (PubMed id 8798754)^{1, 3, 4} Wang Z.-Y.... Deuel T.F. (1996)
Identification of the structural and functional human homolog of the yeast ubiquitin conjugating enzyme UBC9. (PubMed id 8668529)^{1, 3, 4} Yasugi T. and Howley P.M. (1996)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7329	HGNC: 12485	AceView: UBE2I	Ensembl:ENSG00000103275	euGenes: HUgn7329
ECgene: UBE2I	H-InvDB: UBE2I

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for UBE2I	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE2I
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE2I:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2I-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2I		Antibodies for UBE2I
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE2I		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBE2I)
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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for UBE2I (ubc9)

	Recombinant Proteins (UBE2I / UBC9)
	Antibodies (UBE2I / UBC9)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for UBE2I

	Assays/Proteins for UBE2I
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for UBE2I

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UBE2I Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for UBE2I

Summaries
for UBE2I

Genomic Location
for UBE2I

Proteins
for UBE2I

Protein Domains/
Families
for UBE2I

Gene Function
for UBE2I

Pathways & Interactions
for UBE2I

Drugs & Compounds
for UBE2I

Transcripts
for UBE2I

Expression
for UBE2I

Orthologs
for UBE2I

Paralogs
for UBE2I

SNPs/Variants
for UBE2I

Disorders & Mutations
for UBE2I

Medical News
for UBE2I

Publications
for UBE2I

Search for UBE2I

Genome Databases showing UBE2I

Other Databases showing UBE2I

Specialized Databases showing UBE2I

Licensable Technologies
for UBE2I

Services
for UBE2I

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2I (Gene Symbol)
C358B7.1
EC 6.3.2.-
P18
UBC9
UBCE9
p18
SUMO-1-protein ligase
SUMO-protein ligase
Ubiquitin carrier protein 9
Ubiquitin carrier protein I
Ubiquitin-conjugating enzyme E2 I
Ubiquitin-protein ligase I
ubiquitin carrier protein
ubiquitin conjugating enzyme 9
ubiquitin-conjugating enzyme E2I
ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)
ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)
ubiquitin-conjugating enzyme UbcE2A
ubiquitin-like protein SUMO-1 conjugating enzyme
ubiquitin-protein ligase E2I

UBE2I Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor UBE2I

Summariesfor UBE2I

Genomic Locationfor UBE2I

Proteinsfor UBE2I

Protein Domains/Familiesfor UBE2I

Gene Functionfor UBE2I

Pathways & Interactionsfor UBE2I

Drugs & Compoundsfor UBE2I

Transcriptsfor UBE2I

Expression for UBE2I

Orthologsfor UBE2I

Paralogsfor UBE2I

SNPs/Variantsfor UBE2I

Disorders & Mutationsfor UBE2I

Medical Newsfor UBE2I

Publicationsfor UBE2I

Search for UBE2I

Genome Databases showing UBE2I

Other Databases showing UBE2I

Specialized Databases showing UBE2I

Licensable Technologiesfor UBE2I

Servicesfor UBE2I

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2I

Summaries
for UBE2I

Genomic Location
for UBE2I

Proteins
for UBE2I

Protein Domains/
Families
for UBE2I

Gene Function
for UBE2I

Pathways & Interactions
for UBE2I

Drugs & Compounds
for UBE2I

Transcripts
for UBE2I

Expression
for UBE2I

Orthologs
for UBE2I

Paralogs
for UBE2I

SNPs/Variants
for UBE2I

Disorders & Mutations
for UBE2I

Medical News
for UBE2I

Publications
for UBE2I

Licensable Technologies
for UBE2I

Services
for UBE2I