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Aliases for UBE2I Gene

Aliases for UBE2I Gene

  • Ubiquitin Conjugating Enzyme E2 I 2 3
  • Ubiquitin-Conjugating Enzyme E2I (Homologous To Yeast UBC9) 2 3
  • Ubiquitin-Conjugating Enzyme E2I (UBC9 Homolog, Yeast) 2 3
  • Ubiquitin Conjugating Enzyme E2I 3 5
  • Ubiquitin Carrier Protein 9 3 4
  • Ubiquitin Carrier Protein I 3 4
  • Ubiquitin-Protein Ligase I 3 4
  • SUMO-Protein Ligase 3 4
  • UBC9 3 4
  • P18 3 4
  • Ubiquitin-Like Protein SUMO-1 Conjugating Enzyme 3
  • Ubiquitin-Conjugating Enzyme UbcE2A 3
  • Ubiquitin-Conjugating Enzyme E2 I 4
  • Ubiquitin-Conjugating Enzyme E2I 2
  • Ubiquitin Conjugating Enzyme 9 3
  • Ubiquitin-Protein Ligase E2I 3
  • SUMO-1-Protein Ligase 3
  • EC 6.3.2.- 4
  • C358B7.1 3
  • EC 6.3.2 63
  • UBCE9 4

External Ids for UBE2I Gene

Previous GeneCards Identifiers for UBE2I Gene

  • GC16P001375
  • GC16P001299
  • GC16P001287
  • GC16P001359

Summaries for UBE2I Gene

Entrez Gene Summary for UBE2I Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2I Gene

UBE2I (Ubiquitin Conjugating Enzyme E2 I) is a Protein Coding gene. Diseases associated with UBE2I include Pediatric Fibrosarcoma and Congenital Fibrosarcoma. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and Androgen receptor signaling pathway. GO annotations related to this gene include poly(A) RNA binding and ligase activity.

UniProtKB/Swiss-Prot for UBE2I Gene

  • Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at Lys-386.

Gene Wiki entry for UBE2I Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2I Gene

Genomics for UBE2I Gene

Regulatory Elements for UBE2I Gene

Enhancers for UBE2I Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2I on UCSC Golden Path with GeneCards custom track

Promoters for UBE2I Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2I on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UBE2I gene promoter:

Genomic Location for UBE2I Gene

Chromosome:
16
Start:
1,308,880 bp from pter
End:
1,327,018 bp from pter
Size:
18,139 bases
Orientation:
Plus strand

Genomic View for UBE2I Gene

Genes around UBE2I on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2I Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2I Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2I Gene

Proteins for UBE2I Gene

  • Protein details for UBE2I Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63279-UBC9_HUMAN
    Recommended name:
    SUMO-conjugating enzyme UBC9
    Protein Accession:
    P63279
    Secondary Accessions:
    • D3DU69
    • P50550
    • Q15698
    • Q59GX1
    • Q86VB3

    Protein attributes for UBE2I Gene

    Size:
    158 amino acids
    Molecular mass:
    18007 Da
    Quaternary structure:
    • Interacts with SETX (PubMed:24105744). Interacts with HIPK1, HIPK2, PPM1J, RASD2 and TCF3 Interacts with NR2C1; the interaction promotes its sumoylation (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP. Interacts with various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B. Interacts with DNMT1. Interacts with FOXL2. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Interacts with human herpesvirus 6 IE2. Interacts with human adenovirus early E1A protein; this interaction interferes with polysumoylation (Probable). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes sumoylation of DNM1L, mainly in its B domain. Interacts with PML-RARA oncoprotein (via the coiled-colied domain); the interaction is required for sumoylation of the PML-RARA oncoprotein. Interacts with IPO13. Interacts with NFATC2IP; this inhibits formation of poly-SUMO chains. Interacts with FHIT. Interacts with PRKRA and p53/TP53 (By similarity). Interacts with UHRF2. Interacts with NR3C1 and this interaction is enhanced in the presence of RWDD3. Interacts with MTA1. Interacts with ZNF451. Identified in a complex with SUMO2 and UBC9, where one ZNF451 interacts with one UBC9 and two SUMO2 chains, one bound to the UBC9 active site and the other to another region of the same UBC9 molecule. Interacts with Epstein-barr virus protein LMP1.
    SequenceCaution:
    • Sequence=AAH51289.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAD92225.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2I Gene

neXtProt entry for UBE2I Gene

Proteomics data for UBE2I Gene at MOPED

Post-translational modifications for UBE2I Gene

  • Phosphorylation at Ser-71 significantly enhances SUMOylation activity.
  • Ubiquitination at Lys 18, Lys 59, and Lys 65
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2I (UBC9)

Domains & Families for UBE2I Gene

Gene Families for UBE2I Gene

Protein Domains for UBE2I Gene

Suggested Antigen Peptide Sequences for UBE2I Gene

Graphical View of Domain Structure for InterPro Entry

P63279

UniProtKB/Swiss-Prot:

UBC9_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2I: view

Function for UBE2I Gene

Molecular function for UBE2I Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2I,homolog to yeast UBC9,associating with RAD51,RAD52 proteins in the double strand RAD51/RAD52 repair pathway,also associating with UBL1 and PT53,involved in DNA recombination and essential for cell-cycle progression
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine.
UniProtKB/Swiss-Prot Function:
Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at Lys-386.

Enzyme Numbers (IUBMB) for UBE2I Gene

Gene Ontology (GO) - Molecular Function for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008134 transcription factor binding IPI 19744555
GO:0031625 NOT ubiquitin protein ligase binding IBA --
GO:0061630 NOT ubiquitin protein ligase activity IBA --
GO:0071535 RING-like zinc finger domain binding IPI 19407830
genes like me logo Genes that share ontologies with UBE2I: view
genes like me logo Genes that share phenotypes with UBE2I: view

Animal Models for UBE2I Gene

MGI Knock Outs for UBE2I:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2I

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2I Gene

Localization for UBE2I Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2I Gene

Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2I Gene COMPARTMENTS Subcellular localization image for UBE2I gene
Compartment Confidence
cytosol 5
nucleus 5
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005635 nuclear envelope TAS --
GO:0016605 PML body IDA 9885291
GO:1990234 transferase complex IDA 19955185
GO:1990356 sumoylated E2 ligase complex IC 19955185
genes like me logo Genes that share ontologies with UBE2I: view

Pathways & Interactions for UBE2I Gene

genes like me logo Genes that share pathways with UBE2I: view

UniProtKB/Swiss-Prot P63279-UBC9_HUMAN

  • Pathway: Protein modification; protein sumoylation.

SIGNOR curated interactions for UBE2I Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for UBE2I Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006464 cellular protein modification process TAS 8798754
GO:0007067 mitotic nuclear division IEA --
GO:0016032 viral process IEA --
GO:0016925 protein sumoylation IEA,TAS --
genes like me logo Genes that share ontologies with UBE2I: view

Drugs & Compounds for UBE2I Gene

(10) Drugs for UBE2I Gene - From: PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum 2569
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1055
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(3) Additional Compounds for UBE2I Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2I: view

Transcripts for UBE2I Gene

Unigene Clusters for UBE2I Gene

Ubiquitin-conjugating enzyme E2I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2I Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: - - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - -
SP12: - -
SP13:
SP14:

Relevant External Links for UBE2I Gene

GeneLoc Exon Structure for
UBE2I
ECgene alternative splicing isoforms for
UBE2I

Expression for UBE2I Gene

mRNA expression in normal human tissues for UBE2I Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2I Gene



SOURCE GeneReport for Unigene cluster for UBE2I Gene Hs.302903

mRNA Expression by UniProt/SwissProt for UBE2I Gene

P63279-UBC9_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.
genes like me logo Genes that share expression patterns with UBE2I: view

Protein tissue co-expression partners for UBE2I Gene

- Elite partner

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for UBE2I Gene

Orthologs for UBE2I Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2I Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2I 35
  • 90.72 (n)
  • 100 (a)
UBE2I 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2I 35
  • 91.98 (n)
  • 100 (a)
UBE2I 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2i 35
  • 89.24 (n)
  • 100 (a)
Ube2i 16
Ube2i 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2I 35
  • 98.95 (n)
  • 100 (a)
UBE2I 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2i 35
  • 89.24 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2I 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2I 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2I 35
  • 87.13 (n)
  • 100 (a)
UBE2I 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2I 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8764 35
ube2i 35
  • 85.65 (n)
  • 100 (a)
African clawed frog
(Xenopus laevis)
Amphibia ube2i-prov 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
ube2i2 35
  • 81.32 (n)
  • 99.36 (a)
ube2i2 36
  • 99 (a)
OneToMany
ube2i2 36
  • 99 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta lwr 37
  • 86 (a)
lwr 35
  • 70.89 (n)
  • 85.44 (a)
lwr 36
  • 85 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011076 35
  • 68.99 (n)
  • 82.28 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-9 37
  • 76 (a)
ubc-9 36
  • 72 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER056C 35
  • 56.62 (n)
  • 57.69 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E05039g 35
  • 57.91 (n)
  • 57.69 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC9 35
  • 54.91 (n)
  • 56.41 (a)
UBC9 36
  • 56 (a)
OneToOne
UBC9 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SCE1 35
  • 62.77 (n)
  • 66.23 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.2303 35
barley
(Hordeum vulgare)
Liliopsida Hv.919 35
rice
(Oryza sativa)
Liliopsida Os.9019 35
Os03g0123100 35
  • 62.82 (n)
  • 64.74 (a)
corn
(Zea mays)
Liliopsida Zm.4940 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04302 35
  • 58.44 (n)
  • 62.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes hus5 35
  • 60.3 (n)
  • 66.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
OneToOne
Species with no ortholog for UBE2I:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2I Gene

ENSEMBL:
Gene Tree for UBE2I (if available)
TreeFam:
Gene Tree for UBE2I (if available)

Paralogs for UBE2I Gene

Pseudogenes.org Pseudogenes for UBE2I Gene

genes like me logo Genes that share paralogs with UBE2I: view

No data available for Paralogs for UBE2I Gene

Variants for UBE2I Gene

Sequence variations from dbSNP and Humsavar for UBE2I Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4610 -- 1,314,364(+) ATTCC(A/G)GGAAA reference, synonymous-codon
rs7302 -- 1,325,262(+) CCAGG(G/T)CAGCA utr-variant-3-prime
rs8063 -- 1,324,817(+) CGTCA(A/G)AAGGA utr-variant-3-prime
rs9597 -- 1,324,950(+) GGTCT(C/G/T)GATTC utr-variant-3-prime
rs12129 -- 1,325,072(+) AAAAT(C/T)ATAAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for UBE2I Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
nsv471066 CNV Loss 18288195
nsv428316 CNV Gain+Loss 18775914
dgv2505n71 CNV Loss 21882294
dgv2509n71 CNV Loss 21882294
dgv2525n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
nsv833117 CNV Loss 17160897
nsv904962 CNV Gain 21882294
nsv904963 CNV Gain+Loss 21882294
dgv2527n71 CNV Loss 21882294
dgv2528n71 CNV Loss 21882294
dgv2529n71 CNV Loss 21882294
esv22390 CNV Loss 19812545
nsv103725 CNV Loss 16902084

Variation tolerance for UBE2I Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2I Gene

Human Gene Mutation Database (HGMD)
UBE2I

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2I Gene

Disorders for UBE2I Gene

MalaCards: The human disease database

(5) MalaCards diseases for UBE2I Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pediatric fibrosarcoma
  • childhood fibrosarcoma
congenital fibrosarcoma
  • infantile fibrosarcoma
progeria
  • hgps
split hand foot malformation
  • ectrodactyly
setx
- elite association - COSMIC cancer census association via MalaCards
Search UBE2I in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBE2I

Genetic Association Database (GAD)
UBE2I
Human Genome Epidemiology (HuGE) Navigator
UBE2I
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2I
genes like me logo Genes that share disorders with UBE2I: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2I Gene

Publications for UBE2I Gene

  1. Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. (PMID: 8565643) Watanabe T.K. … Shin S. (Cytogenet. Cell Genet. 1996) 2 3 4 23 67
  2. Polymorphisms in the UBC9 and PIAS3 genes of the SUMO-conjugating system and breast cancer risk. (PMID: 19760037) DA1nnebier T. … Hamann U. (Breast Cancer Res. Treat. 2010) 3 23
  3. Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy. (PMID: 19859084) Han J.Y. … Lee J.S. (Pharmacogenomics J. 2010) 3 23
  4. A novel mechanism whereby BRCA1/1a/1b fine tunes the dynamic complex interplay between SUMO-dependent/independent activities of Ubc9 on E2-induced ERalpha activation/repression and degradation in breast cancer cells. (PMID: 19287951) Xu J. … Rao V.N. (Int. J. Oncol. 2009) 3 23
  5. Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade. (PMID: 19358266) DA1nnebier T. … Hamann U. (Int. J. Cancer 2009) 3 23

Products for UBE2I Gene

Sources for UBE2I Gene

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