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UBE2I Gene

protein-coding   GIFtS: 74
GCID: GC16P001359

Ubiquitin-Conjugating Enzyme E2I

(Previous names: ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9),...)
  See UBE2I-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2I1 2     SUMO-Conjugating Enzyme UBC92
Ubiquitin-Conjugating Enzyme E2I (Homologous To Yeast UBC9)1 2     Ubiquitin Conjugating Enzyme 92
Ubiquitin-Conjugating Enzyme E2I (UBC9 Homolog, Yeast)1 2     Ubiquitin-Conjugating Enzyme UbcE2A2
Ubiquitin Carrier Protein 92 3     Ubiquitin-Like Protein SUMO-1 Conjugating Enzyme2
Ubiquitin Carrier Protein I2 3     Ubiquitin-Protein Ligase E2I2
Ubiquitin-Protein Ligase I2 3     EC 6.3.2.-3
UBC92 3     UBCE93
SUMO-Protein Ligase2 3     p183
C358B7.12     Ubiquitin-Conjugating Enzyme E2 I3
P182     EC 6.3.28
SUMO-1-Protein Ligase2     

External Ids:    HGNC: 124851   Entrez Gene: 73292   Ensembl: ENSG000001032757   OMIM: 6016615   UniProtKB: P632793   

Export aliases for UBE2I gene to outside databases

Previous GC identifers: GC16P001375 GC16P001299 GC16P001287


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2I Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2I Gene:
UBE2I (ubiquitin-conjugating enzyme E2I) is a protein-coding gene. Diseases associated with UBE2I include cortisol resistance. GO annotations related to this gene include enzyme binding and transcription factor binding.

UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279
Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and
catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can
catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear
architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'

Gene Wiki entry for UBE2I Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2I gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2I promoter sequence
   Search Chromatin IP Primers for UBE2I

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2I


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

UBE2I Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2I gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P001359:  view genomic region     (about GC identifiers)

Start:
1,355,548 bp from pter      End:
1,377,019 bp from pter
Size:
21,472 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279 (See protein sequence)
Recommended Name: SUMO-conjugating enzyme UBC9  
Size: 158 amino acids; 18007 Da
Subunit: Interacts with HIPK1, HIPK2, PPM1J, RASD2 and TCF3 Interacts with NR2C1; the interaction promotes its
sumoylation (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP.
Interacts with various transcription factors such as TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with
RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B. Interacts
with DNMT1. Interacts with FOXL2. Forms a complex with SENP6 and UBE2I in response to UV irradiation. Interacts
with human herpesvirus 6 IE2. Interacts with human adenovirus early E1A protein; this interaction interferes with
polysumoylation (Probable). Interacts with DNM1l (via its GTPase and B domains); the interaction promotes
sumoylation of DNM1L, mainly in its B domain. Interacts with PML-RARA oncoprotein (via the coiled-colied domain);
the interaction is required for sumoylation of the PML-RARA oncoprotein. Interacts with IPO13. Interacts with
NFATC2IP; this inhibits formation of poly-SUMO chains. Interacts with FHIT. Interacts with PRKRA and p53/TP53 (By
similarity). Interacts with UHRF2
Sequence caution: Sequence=AAH51289.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAD92225.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for UBE2I (see all 17):
1A3S (3D)        1KPS (3D)        1Z5Q (3D)        1Z5S (3D)        2GRN (3D)        2GRO (3D)    
Secondary accessions: D3DU69 P50550 Q15698 Q59GX1 Q86VB3

Explore the universe of human proteins at neXtProt for UBE2I: NX_P63279

Explore proteomics data for UBE2I at MOPED

Post-translational modifications: 

  • Phosphorylation at Ser-71 significantly enhances SUMOylation activity1
  • Ubiquitination2 at Lys18, Lys59, Lys65
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2I (P63279) (see all 6)
     DWRPAIT  HPNVYPSGT  GIQELLNEPNIQ  PAITIKQILLGIQ 


    See UBE2I Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_003336.1  NP_919235.1  NP_919236.1  NP_919237.1  

    ENSEMBL proteins: 
     ENSP00000348056   ENSP00000324897   ENSP00000380649   ENSP00000380650   ENSP00000456188  
     ENSP00000385009   ENSP00000457064   ENSP00000384568   ENSP00000455893   ENSP00000384361  
     ENSP00000455252  
    Reactome Protein details: P63279

    UBE2I Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    4 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR027230 Ubc9

    Graphical View of Domain Structure for InterPro Entry P63279

    ProtoNet protein and cluster: P63279

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2I           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBC9_HUMAN, P63279
    Function: Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and
    catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can
    catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear
    architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'
    Catalytic activity: ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine

         Genatlas biochemistry entry for UBE2I:
    ubiquitin conjugating enzyme E2I,homolog to yeast UBC9,associating with RAD51,RAD52 proteins in the double strand
    RAD51/RAD52 repair pathway,also associating with UBL1 and PT53,involved in DNA recombination and essential for
    cell-cycle progression

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS19955185
    GO:0005515protein binding IPI10871618
    GO:0005524ATP binding IEA--
    GO:0008022protein C-terminus binding IEA--
    GO:0008134transcription factor binding IPI19744555
         
    Find genes that share ontologies with UBE2I           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2I:
     Decreased Wnt reporter activit  Increased cell death in HCT116  Synthetic lethal with Ras 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ube2i):
     cellular  embryogenesis  hematopoietic system  mortality/aging  no phenotypic analysis 

    Find genes that share phenotypes with UBE2I           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ube2itm1.1Adej for UBE2I

       genOway: Develop your customized and physiologically relevant rodent model for UBE2I

    miRNA
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    miRTarBase miRNAs that target UBE2I:
    hsa-mir-30c-5p (MIRT005090), hsa-let-7b-5p (MIRT032401), hsa-mir-324-5p (MIRT043111), hsa-mir-200c-3p (MIRT005087), hsa-mir-30e-5p (MIRT003339), hsa-mir-1 (MIRT023885), hsa-mir-188-5p (MIRT005088)

    Block miRNA regulation of human, mouse, rat UBE2I using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2I (see all 31):
    hsa-miR-485-5p hsa-miR-30c hsa-miR-122* hsa-miR-16-2* hsa-miR-429 hsa-miR-188-5p hsa-miR-10b hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidUBE2I 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector (see all 4): UBE2I (NM_003345)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2I
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2I
    Addgene plasmids for UBE2I 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBC9_HUMAN, P63279: Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal
    complexes. Recruited by BCL11A into the nuclear body (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000795synaptonemal complex TAS8610150
    GO:0001650fibrillar center IEA--
    GO:0005634nucleus IDA14752048
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--

    Find genes that share ontologies with UBE2I           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2I About   (see all 26)  
    See pathways by source

    SuperPathContained pathways About
    1Processing and Activation of SUMO
    Processing and Activation of SUMO
    SUMOylation0.00
    Transfer of SUMO from E1 to E2 (UBE2I, UBC9)0.00
    2Packaging Of Telomere Ends
    Meiotic Synapsis0.66
    Chromosome Maintenance0.62
    3Proteolysis Putative SUMO 1 pathway
    DNA damage Role of SUMO in p53 regulation0.33
    Proteolysis Putative SUMO 1 pathway0.33
    4Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Post-translational protein modification0.43
    Metabolism of proteins0.30
    5Cell Cycle, Mitotic
    Cell Cycle0.90


    Find genes that share SuperPaths with UBE2I           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2I (see all 6)
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions
    Glucocorticoid Receptor Signaling
    JAK-STAT Pathway
    SUMO Pathway

    1 Cell Signaling Technology (CST) Pathway for UBE2I
        Protein Stability

    3 GeneGo (Thomson Reuters) Pathways for UBE2I
        Proteolysis Putative SUMO-1 pathway
    DNA damage Role of SUMO in p53 regulation
    Development Glucocorticoid receptor signaling

    Selected BioSystems Pathways for UBE2I (see all 8)
        Androgen receptor signaling pathway
    TNF-alpha/NF-kB Signaling Pathway
    Signaling events mediated by HDAC Class I
    Sumoylation by RanBP2 regulates transcriptional repression
    Signaling events mediated by HDAC Class II


    2 Reactome Pathways for UBE2I
        SUMO is transferred from E1 to E2 (UBE2I, UBC9)
    Meiotic synapsis


    4 Kegg Pathways  (Kegg details for UBE2I):
        RNA transport
    NF-kappa B signaling pathway
    Ubiquitin mediated proteolysis
    MicroRNAs in cancer

    UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279
    Pathway: Protein modification; protein sumoylation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2I: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2I

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2I (P632791, 2, 3 ENSP000003248974) via UniProtKB, MINT, STRING, and/or I2D (see all 530)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST4H4P628053, ENSP000003507674I2D: score=2 STRING: ENSP00000350767
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP19955185
    GO:0006464cellular protein modification process TAS8798754
    GO:0006511ubiquitin-dependent protein catabolic process TAS8565643
    GO:0007059chromosome segregation IEA--
    GO:0007067mitosis IEA--

    Find genes that share ontologies with UBE2I           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for UBE2I (UBC9)

    4 HMDB Compounds for UBE2I    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    7 Novoseek inferred chemical compound relationships for UBE2I gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 63.9 6 16029420 (1), 19107417 (1), 17336575 (1), 15272016 (1) (see all 5)
    topotecan 26.5 2 15087395 (2)
    testosterone 4.12 3 10383460 (2), 17336575 (1)
    atp 0 2 16275321 (1)
    glucose 0 9 17536066 (3), 16296343 (3), 16955077 (1)
    steroid 0 1 10383460 (1)
    cysteine 0 3 9353268 (1), 9757105 (1), 9855622 (1)

    2 PharmGKB related drug/compound annotations for UBE2I gene    About this table
    Drug/compound PharmGKB Annotation
    cisplatinCA  
    irinotecanCA  



    Find genes that share compounds with UBE2I           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2I gene (4 alternative transcripts): 
    NM_003345.4  NM_194259.2  NM_194260.2  NM_194261.2  

    Unigene Cluster for UBE2I:

    Ubiquitin-conjugating enzyme E2I
    Hs.302903  [show with all ESTs]
    Unigene Representative Sequence: NM_194259
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000339021 ENST00000355803(uc002cld.2) ENST00000325437(uc002clc.2)
    ENST00000397514(uc002clg.2) ENST00000397515(uc002clf.2) ENST00000473256(uc002cle.2)
    ENST00000568288 ENST00000567383 ENST00000403747 ENST00000568209 ENST00000562482
    ENST00000566587 ENST00000406620 ENST00000562470 ENST00000567074 ENST00000402301(uc002clh.1 uc002cli.1)
    ENST00000566775 ENST00000566159
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    eBioscience FlowRNA Probe Sets ( VA1-12206) for UBE2I 

    Additional mRNA sequence: 

    AB208988.1 AJ002385.1 AK291118.1 BC000427.2 BC004429.1 BC051289.1 BC064492.1 BT006932.1 
    BT007010.1 D45050.1 U29092.1 U31882.1 U31933.1 U38785.1 U45328.1 U66818.1 
    X96427.1 

    Selected DOTS entries (see all 25):

    DT.452937  DT.220036  DT.100802787  DT.100802786  DT.91758126  DT.95263931  DT.91758135  DT.75112535 
    DT.95263936  DT.91758122  DT.120698929  DT.91758123  DT.95323948  DT.100009715  DT.100802788  DT.91758153 
    DT.95221080  DT.100802782  DT.40117461  DT.87078190  DT.95263930  DT.95263933  DT.97774979  DT.97787746 

    Selected AceView cDNA sequences (see all 495):

    BU660728 BE388002 NM_003345 BI050327 BQ688282 BM552837 BU539585 AA148406 
    NM_194260 NM_194259 AI127982 CR590087 BQ688212 NM_194261 BG433668 AA297526 
    CR604763 AA662426 BQ953214 BC000427 BU072841 AA296848 BU146357 BM995373 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBE2I (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
    SP1:                    -     -     -     -     -     -                       -                 -     -     -                                             
    SP2:              -     -     -     -     -     -     -                       -                 -     -     -                                             
    SP3:                          -     -                 -                       -                 -     -     -                                             
    SP4:                          -     -     -     -     -                       -                 -     -     -                                             
    SP5:                          -     -     -     -     -                       -                 -     -     -                                             


    ECgene alternative splicing isoforms for UBE2I

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    UBE2I expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTCTCACCG
    UBE2I Expression
    About this image


    UBE2I expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Uterus (Reproductive System)
    UBE2I Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2I Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.302903

    UniProtKB/Swiss-Prot: UBC9_HUMAN, P63279
    Tissue specificity: Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also
    expressed in testis and thymus

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2I: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Parkinson's Disease in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2I

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2I gene from Selected species (see all 29)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2i1 , 5 ubiquitin-conjugating enzyme E2I1, 5 89.24(n)1
    100(a)1
      17 (12.53 cM)5
    221961  NM_011665.41  NP_035795.11 
     252619165 
    chicken
    (Gallus gallus)
    Aves UBE2I1 ubiquitin-conjugating enzyme E2I 87.13(n)
    100(a)
      374123  NM_204265.1  NP_989596.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2I6
    ubiquitin-conjugating enzyme E2I
    100(a)
    1 ↔ 1
    GL343612.1(248601-260071)
    African clawed frog
    (Xenopus laevis)
    Amphibia ube2i-prov2 ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 86.8(n)    BC046273.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC058302.12   -- 83.54(n)   114445  BC058302.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta lwr1 , 3 female meiosis protein tagging3
    lesswright1
    86(a)3
    70.89(n)1
    85.44(a)1
      2 21D13
    332261  NM_001272904.11  NP_001259833.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-93 ubiquitin-conjugating enzyme 76(a)   IV(4651090-4652133)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC9(YDL064W)4
    UBC91
    SUMO-conjugating enzyme involved in the Smt3p conjugation more4
    UBC91
    54.91(n)1
    56.41(a)1
      4(337487-338070)4
    8514951, 4  NP_010219.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SCE11 SCE1 62.77(n)
    66.23(a)
      824956  NM_115649.2  NP_191346.1 
    rice
    (Oryza sativa)
    Liliopsida Os.90192 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.99(n)    AK105227.1 


    ENSEMBL Gene Tree for UBE2I (if available)
    TreeFam Gene Tree for UBE2I (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2I gene
    Selected SIMAP similar genes for UBE2I using alignment to 6 protein entries:     UBC9_HUMAN (see all proteins) (see all similar genes):
    HR6A    UBE2E3    UBE2A    UBE2N    UBE2D3    UBE2B
    UBE2E2    UBE2M    UBE2D2    UBE2NL    UBE2E1    UBE2S
    UBE2H    UBE2D4    UBE2D1    UBE2L6    UBE2T    CDC34

    Find genes that share paralogs with UBE2I           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UBE2I
    PGOHUM00000240610


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2I (see all 715)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1168591381,2
    F--1286082(+) TGTACC/TCAGGG 2 -- us2k11Minor allele frequency- T:0.01NA 120
    rs66001311,2
    C,H--1286234(+) CCATGT/ACCCTC 2 -- us2k16Minor allele frequency- A:0.09NA WA CSA 11
    rs66001321,2
    C,A,H--1286245(+) ACCCCC/TACCTG 2 -- us2k15Minor allele frequency- T:0.00NA WA 10
    rs735002961,2
    C,F--1286325(+) CAGGAC/AAGGAA 2 -- us2k12Minor allele frequency- A:0.05WA 120
    rs794277631,2
    F--1286352(+) GCCATG/ATCTCC 2 -- us2k11Minor allele frequency- A:0.01WA 118
    rs559785021,2
    C,F--1286469(+) CCCAGC/GCACAC 2 -- us2k12Minor allele frequency- G:0.06WA 120
    rs49848041,2
    C,F,A,H--1286561(+) TGCAGT/CGGGAT 2 -- us2k119Minor allele frequency- C:0.03NS EA WA NA CSA 1207
    rs1483281471,2
    --1286623(+) CTGACA/GCCTCC 2 -- us2k10--------
    rs1420844611,2
    --1286641(+) GCCCTA/GTGCTG 2 -- us2k10--------
    rs763764141,2
    F--1286669(+) ATGGCA/G/TTTGGA 2 -- us2k11NA 2

    HapMap Linkage Disequilibrium report for UBE2I (1355548 - 1377019 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for UBE2I (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv103725CNV Loss16902084
    nsv833117CNV Loss17160897
    nsv904954CNV Loss21882294
    dgv2505n71CNV Loss21882294
    nsv904950CNV Loss21882294
    esv22390CNV Loss19812545
    dgv2528n71CNV Loss21882294
    dgv2527n71CNV Loss21882294
    dgv2529n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): UBE2I
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2I
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2I

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601661    OMIM disorders: --

    1 disease for UBE2I:    
    About MalaCards
    cortisol resistance


    Find genes that share disorders with UBE2I           About GenesLikeMe

    10 Novoseek inferred disease relationships for UBE2I gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma lung 17.1 3 16300471 (1), 16758298 (1)
    shock 10.2 1 9514881 (1)
    melanoma 4.02 5 17297476 (2), 16300471 (1), 16758298 (1)
    ovarian carcinoma 3.48 3 16300471 (1), 16758298 (1)
    leukemia 0 1 14739995 (1)
    carcinoma squamous cell 0 3 19309722 (2), 17970065 (1)
    ischemia 0 2 16955077 (1), 12415119 (1)
    insulin sensitivity 0 1 17536066 (1)
    tumors 0 20 19760037 (3), 15735760 (3), 19309722 (3), 15087395 (3) (see all 7)
    cancer 0 3 16300471 (2)

    Genetic Association Database (GAD): UBE2I
    Human Genome Epidemiology (HuGE) Navigator: UBE2I (5 documents)

    Export disorders for UBE2I gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2I gene, integrated from 10 sources (see all 391):
    (articles sorted by number of sources associating them with UBE2I)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression, and mapping of UBE2I, a novel gene encoding a human homologue of yeast ubiquitin-conjugating enzymes which are critical for regulating the cell cycle. (PubMed id 8565643)1, 2, 3, 9 Watanabe T.K.... Shin S. (Cytogenet. Cell Genet. 1996)
    2. Ubc9 interacts with the androgen receptor and activates receptor- dependent transcription. (PubMed id 10383460)1, 2, 9 Poukka H.... Jaenne O.A. (J. Biol. Chem. 1999)
    3. Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: a genetic association study. (PubMed id 19765634)1, 4, 9 Ahn K....Koh Y.H. (Neurosci. Lett. 2009)
    4. Functional interaction between human herpesvirus 6 immediate-early 2 protein and ubiquitin-conjugating enzyme 9 in the absence of sumoylation. (PubMed id 17005699)1, 2, 9 Tomoiu A.... Flamand L. (J. Virol. 2006)
    5. Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation. (PubMed id 12924945)1, 2, 9 Tatham M.H.... Chen Y. (Biochemistry 2003)
    6. Common variants in the UBC9 gene encoding the SUMO-conjugating enzyme are associated with breast tumor grade. (PubMed id 19358266)1, 4, 9 DA1nnebier T....Hamann U. (Int. J. Cancer 2009)
    7. Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction. (PubMed id 17466333)1, 2, 9 Capili A.D. and Lima C.D. (J. Mol. Biol. 2007)
    8. Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection. (PubMed id 15608651)1, 2, 9 Tatham M.H.... Hay R.T. (Nat. Struct. Mol. Biol. 2005)
    9. Association of SUMO1 and UBC9 genotypes with tumor response in non-small-cell lung cancer treated with irinotecan-based chemotherapy. (PubMed id 19859084)1, 4, 9 Han J.Y....Lee J.S. (Pharmacogenomics J. 2010)
    10. Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9- Nup358 complex. (PubMed id 15931224)1, 2, 9 Reverter D. and Lima C.D. (Nature 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7329 HGNC: 12485 AceView: UBE2I Ensembl:ENSG00000103275 euGenes: HUgn7329
    ECgene: UBE2I Kegg: 7329 H-InvDB: UBE2I

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2I Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2I Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2I gene:
    Search GeneIP for patents involving UBE2I

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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