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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2H Gene

protein-coding   GIFtS: 63
GCID: GC07M129470

ubiquitin-conjugating enzyme E2H

(Previous names: ubiquitin-conjugating enzyme E2H (homologous to yeast UBC8),...)
 Explore 5 diseases affiliated with
UBE2H via our new
 Human Malady Compendium 
Biological research products
for UBE2H
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2H1 2     Ubiquitin-Protein Ligase H2 3
UBC81 2 5     EC 6.3.2.193 8
GID31 2     UBCH22 5
UBCH1 2     E2-20K2
Ubiquitin-Conjugating Enzyme E2H (Homologous To Yeast UBC8)1 2     GID Complex Subunit 3, UBC8 Homolog2
Ubiquitin-Conjugating Enzyme E2H (UBC8 Homolog, Yeast)1 2     Ubiquitin-Conjugating Enzyme E2 H2
Ubiquitin Carrier Protein H2 3     UbcH23
Ubiquitin-Conjugating Enzyme E2-20K2 3     

External Ids:    HGNC: 124841   Entrez Gene: 73282   Ensembl: ENSG000001865917   OMIM: 6010825   UniProtKB: P622563   

Export aliases for UBE2H gene to outside databases

Previous GC identifers: GC07M127950 GC07M129009 GC07M129026 GC07M129064 GC07M129257 GC07M123834


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2H:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or
E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the
E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98%
identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this
gene and they encode distinct isoforms. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: UBE2H_HUMAN, P62256
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A

Gene Wiki entry for UBE2H


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2H gene promoter:
         ER-alpha   C/EBPbeta   GATA-3   PPAR-alpha   FAC1   SRY   GATA-6   FOXO1a   c-Myb   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): UBE2H promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2H

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q32   Ensembl cytogenetic band:  7q32.2   HGNC cytogenetic band: 7q32

UBE2H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2H gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M129470:  view genomic region     (about GC identifiers)

Start:
129,470,572 bp from pter      End:
129,592,789 bp from pter
Size:
122,218 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 128,857,649-128,977,424     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBE2H_HUMAN, P62256 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 H  
Size: 183 amino acids; 20655 Da
1 PDB 3D structure from and Proteopedia for UBE2H:
2Z5D (3D)    
Secondary accessions: A4D1L6 C9JY93 P37286 Q7Z6F4
Alternative splicing: 2 isoforms:  P62256-1   P62256-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2H: NX_P62256

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P62256

  • 2 DME Specific Peptides for UBE2H (P62256)
     KSPSIGF  VCLDVINQTW 

    UBE2H Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001189427.1  NP_003335.1  NP_874356.1  

    ENSEMBL proteins: 
     ENSP00000347836   ENSP00000419097   ENSP00000417681   ENSP00000419689   ENSP00000417709  
     ENSP00000419750  
    Reactome Protein details: P62256
    Human Recombinant Protein Products: 
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    Uscn Proteins for UBE2H


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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UBE2H for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P62256

    ProtoNet protein and cluster: P62256

    1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2H_HUMAN, P62256
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: UBE2H_HUMAN, P62256
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2H:
    ubiquitin conjugating enzyme H2A,homolog to yeast UBC8

    Enzyme Number (IUBMB): EC 6.3.2.191 2

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    hsa-miR-607 hsa-miR-361-5p hsa-miR-300 hsa-miR-3146 hsa-miR-199a-3p hsa-miR-1258 hsa-miR-219-5p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidUBE2H 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2H

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----


    UBE2H for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation1.00
    Polyubiquitination of substrate0.75
    Class I MHC mediated antigen processing & presentation0.83
    Ubiquitin mediated proteolysis0.36
    2Immune System
    Immune System1.00
    Adaptive Immune System0.59
    3Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis1.00
    4Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions1.00
    5APC-Cdc20 mediated degradation of Nek2A
    Common schema of ubiquitination0.35

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for UBE2H
        Common schema of ubiquitination

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2H
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    5        Reactome Pathways for UBE2H
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE2H):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2H_HUMAN, P62256
    Pathway: Protein modification; protein ubiquitination


    UBE2H for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/108 Interacting proteins for UBE2H (P622561, 3 ENSP000003478364) via UniProtKB, MINT, STRING, and/or I2D (see all 108)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H2AA3Q6FI133, ENSP000003581584I2D: score=1 STRING: ENSP00000358158
    CD99P142093, ENSP000003705884I2D: score=3 STRING: ENSP00000370588
    DTX3Q8N9I93, ENSP000003380504I2D: score=2 STRING: ENSP00000338050
    MARCH2Q9P0N83, ENSP000002155554I2D: score=2 STRING: ENSP00000215555
    MKRN3Q130643, ENSP000003138814I2D: score=2 STRING: ENSP00000313881
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS8132613
    GO:0016567protein ubiquitination ----
    GO:0070936protein K48-linked ubiquitination IDA--
    GO:0070979protein K11-linked ubiquitination IDA--


    UBE2H for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2H

    4 HMDB Compounds for UBE2H    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about UBE2H 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2H gene (3 alternative transcripts): 
    NM_001202498.1  NM_003344.3  NM_182697.2  

    Unigene Cluster for UBE2H:

    Ubiquitin-conjugating enzyme E2H
    Hs.643548  [show with all ESTs]
    Unigene Representative Sequence: NM_003344
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355621(uc022aln.1 uc003vpf.2 uc003vpg.2) ENST00000473814
    ENST00000496698 ENST00000483368 ENST00000472396 ENST00000480245 ENST00000486283
    ENST00000463272 ENST00000490974

    miRNA
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    8/93 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2H (see all 93):
    hsa-miR-607 hsa-miR-361-5p hsa-miR-300 hsa-miR-3146 hsa-miR-199a-3p hsa-miR-1258 hsa-miR-219-5p hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidUBE2H 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2H
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    Additional cDNA sequence: 

    AB451490.1 AK024519.1 AK026094.1 AK316590.1 AY302138.1 BC006277.2 BT006756.1 Z29328.1 
    Z29330.1 Z29331.1 

    24/25 DOTS entries (see all 25):

    DT.87017898  DT.87017436  DT.95243234  DT.99980512  DT.91994447  DT.91647119  DT.40300964  DT.121119802 
    DT.100845527  DT.95243162  DT.100845532  DT.92008696  DT.100729584  DT.100845530  DT.121119701  DT.121119747 
    DT.121119759  DT.91761141  DT.91886072  DT.99989542  DT.40235291  DT.91761162  DT.92406927  DT.95243164 

    24/938 AceView cDNA sequences (see all 938):

    CA447779 AI127458 AJ713803 W48674 BQ005443 F10833 AW051443 AI246731 
    AA613942 BI768179 N74176 BT006756 AW449722 AI640544 AA010909 Z41869 
    AI333252 AI091471 BG249764 AI972678 AI082192 W72052 BI918244 AI016361 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGAAGCAGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See UBE2H Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2H

    SOURCE GeneReport for Unigene cluster: Hs.643548
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2H: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2H
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2H

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2H gene from 9/39 species (see all 39)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves UBE2H1 ubiquitin-conjugating enzyme E2H 89.25(n)
    100(a)
      416678  NM_001030647.1  NP_001025818.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2H6
    --
    100(a)
    1 ↔ 1
    GL343708.1(12379-45931)
    African clawed frog
    (Xenopus laevis)
    Amphibia ube2h-prov2 ubiquitin-conjugating enzyme E2H 90.47(n)    BC044038.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc07a052 Danio rerio mRNA similar to ubiquitin-conjugating enzyme more 82.23(n)    BC049139.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubc-E2H1 , 3 ubiquitin conjugating enzyme3
    CG2257-PA1
    78(a)
    (best of 2)3
    65.76(n)1
    78.69(a)1
      317281  NM_132210.21  NP_572438.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-81 , 3 Protein UBC-81 56(a)3
    61.17(n)1
    65.34(a)1
      IV(2704696-2707234)3
    1908021  NM_067844.21  NP_500245.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC8(YEL012W)4
    UBC81
    Ubiquitin-conjugating enzyme that negatively regulates more4
    Ubc8p1
    55.06(n)1
    54.49(a)1
      5(131772-132551)4
    8567041, 4  NP_010904.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC51 ubiquitin-conjugating enzyme E2 5 58.19(n)
    54.91(a)
      842683  NM_105055.2  NP_564817.2 
    rice
    (Oryza sativa)
    Liliopsida AK066993.12   -- 75(n)    AK066993.1 


    ENSEMBL Gene Tree for UBE2H (if available)
    TreeFam Gene Tree for UBE2H (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2H gene
    18 SIMAP similar genes for UBE2H using alignment to 7 protein entries:     UBE2H_HUMAN (see all proteins):
    HR6A    UBE2N    UBE2D3    UBE2D4    UBE2D2    UBE2D1
    UBE2B    UBE2A    UBE2S    UBE2L6    UBE2E2    UBE2E1
    UBE2L3    UBE2C    UBE2K    UBE2T    UBE2NL    UBE2I

    UBE2H for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBE2H
    PGOHUM00000249724


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2037 NCBI SNPs in UBE2H are shown (see all 2037    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs8736641,2
    C,F,O,H,--129470167(-) CTGATC/TTGCCT 3 -- ds500125Minor allele frequency- T:0.07MN NS EA NA WA 3066
    rs765225941,2
    F,--129470282(+) ACCTTC/TGGGCT 3 -- ds50012Minor allele frequency- T:0.07NA EA 240
    rs1901171111,2
    --129470445(+) GCATTC/GTAAGA 3 -- ds50010--------
    rs731596961,2
    --129470575(+) CATTTA/GCCAAG 3 -- ut310--------
    rs1818146951,2
    --129470588(+) ATATAC/TACGTT 3 -- ut310--------
    rs1870730641,2
    --129470634(+) CTATTA/GAGAGG 3 -- ut310--------
    rs1420680511,2
    C,--129470656(+) GAGGC-/ATATGTG 3 -- ut310--------
    rs38324591,2
    C--129470658(+) GGCAT-/ATGTGTC 3 -- ut310--------
    rs1140135181,2
    --129470708(+) GAGAAA/CGGTGG 3 -- ut311Minor allele frequency- C:0.01WA 118
    rs37349261,2
    C,F,H,--129470709(+) AGAAAG/AGTGGA 3 -- ut31 trp39Minor allele frequency- A:0.02EA NS NA 2264

    HapMap Linkage Disequilibrium report for UBE2H (129470572 - 129592789 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for UBE2H
         1 CNV: 6572

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    UBE2H for disorders           About GeneDecksing

    OMIM gene information: 601082    OMIM disorders: --

    5 diseases for UBE2H:    About MalaCards
    autism spectrum disorder    autistic disorder    muscular atrophy    cblc
    malaria

    Human Genome Epidemiology (HuGE) Navigator: UBE2H (3 documents)

    Export disorders for UBE2H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2H gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with UBE2H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A human ubiquitin-conjugating enzyme homologous to yeast UBC8. (PubMed id 8132613)1, 2, 3, 9 Kaiser P.... Schneider R. (1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder. (PubMed id 14639049)1, 9 Vourc'h P....Andres C. (2003)
    6. Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. (PubMed id 7761435)1, 9 Wefes I....Finley D. (1995)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. UBR2 of the N-end rule pathway is required for chromos ome stability via histone ubiquitylation in spermatocytes and somatic cells. (PubMed id 22616001)1 An J.Y....Kwon Y.T. (2012)
    10. Dynamically regulated sumoylation of HDAC2 controls p5 3 deacetylation and restricts apoptosis following genotoxic stress. (PubMed id 22493095)1 Brandl A....Kramer O.H. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7328 HGNC: 12484 AceView: UBE2H Ensembl:ENSG00000186591 euGenes: HUgn7328
    ECgene: UBE2H Kegg: 7328 H-InvDB: UBE2H

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2H Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2H gene:
    Search GeneIP for patents involving UBE2H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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