Aliases for UBE2G2 Gene
External Ids for UBE2G2 Gene
Previous GeneCards Identifiers for UBE2G2 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for UBE2G2 Gene
UBE2G2 (Ubiquitin-Conjugating Enzyme E2G 2) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2R2.
UniProtKB/Swiss-Prot for UBE2G2 Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).