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UBE2G2 Gene

protein-coding   GIFtS: 68
GCID: GC21M046188

Ubiquitin-Conjugating Enzyme E2G 2

(Previous names: ubiquitin-conjugating enzyme E2G 2 (homologous to yeast...)
  See UBE2G2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Ubiquitin-Conjugating Enzyme E2G 21 2     UBC72 5
Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7)1 2     Human Ubiquitin Conjugating Enzyme G211
Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast)1 2     Ubiquitin Conjugating Enzyme 72
Ubiquitin Carrier Protein G22 3     Ubiquitin Conjugating Enzyme G22
Ubiquitin-Protein Ligase G22 3     Ubiquitin-Conjugating Enzyme E2 G22
EC 6.3.2.193 8     

External Ids:    HGNC: 124831   Entrez Gene: 73272   Ensembl: ENSG000001847877   OMIM: 6031245   UniProtKB: P606043   

Export aliases for UBE2G2 gene to outside databases

Previous GC identifers: GC21M042698 GC21M045045 GC21M045013 GC21M031563


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2G2 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100%
sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in
adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this
gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for UBE2G2 Gene:
UBE2G2 (ubiquitin-conjugating enzyme E2G 2) is a protein-coding gene. Diseases associated with UBE2G2 include cri-du-chat syndrome. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2G1.

UniProtKB/Swiss-Prot: UB2G2_HUMAN, P60604
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD)

Gene Wiki entry for UBE2G2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence at NCBI GenBank:
NC_000021.8  NC_018932.2  NT_011512.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2G2 gene promoter:
         AREB6   MEF-2A   p53   AML1a   Bach2   aMEF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2G2 promoter sequence

   Search Chromatin IP Primers for UBE2G2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2G2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
UBE2G2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2G2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M046188:   GeneLoc Nature:405,311-319
Start:
46,188,495 bp from pter       31,698,366 bp from centromere
End:
46,221,934 bp from pter 31,731,118 bp from centromere
Size:
33,440 bases 32,753 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF032456
genomic clones: P225L15


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UB2G2_HUMAN, P60604 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 G2  
Size: 165 amino acids; 18566 Da
5 PDB 3D structures from and Proteopedia for UBE2G2:
2CYX (3D)        2KLY (3D)        2LXP (3D)        3H8K (3D)        4LAD (3D)    
Secondary accessions: A6NMQ7 A8K3L4 D3DSL7 P56554
Alternative splicing: 2 isoforms:  P60604-1   P60604-2   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for UBE2G2: NX_P60604

Explore proteomics data for UBE2G2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys7, Lys153, Lys156
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2G2 (P60604) (see all 5)
     VCISILH  DYPLSPPK  HPNIYPDG  SMLAEPNDESGAN 


    See UBE2G2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001189418.1  NP_003334.2  NP_872630.1  

    ENSEMBL proteins: 
     ENSP00000338348   ENSP00000418423   ENSP00000331384   ENSP00000420671  
    Reactome Protein details: P60604

    UBE2G2 Human Recombinant Protein Products:

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    Novus Biologicals UBE2G2 Proteins
    Novus Biologicals UBE2G2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for UBE2G2

     
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    Search eBioscience for ELISAs for UBE2G2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry P60604

    ProtoNet protein and cluster: P60604

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2G2_HUMAN, P60604
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2G2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2G2_HUMAN, P60604
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2G2:
    ubiquitin conjugating enzyme,homolog to yeast UBC7,with two transcript,ubiquitously expressed

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI17681147
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with UBE2G2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2G2:
     Increased S DNA content  Increased cell death in HCC-19  Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2G2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2G2
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    miRNA
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    miRTarBase miRNAs that target UBE2G2:
    hsa-mir-125a-5p (MIRT045715), hsa-mir-128-3p (MIRT045887), hsa-mir-615-3p (MIRT040299)

    Block miRNA regulation of human, mouse, rat UBE2G2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2G2 (see all 24):
    hsa-miR-3910 hsa-miR-137 hsa-let-7d hsa-miR-1263 hsa-miR-4263 hsa-let-7c hsa-let-7g hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidUBE2G2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE2G2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): UBE2G2 (NM_003343)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2G2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2G2
    Addgene plasmids for UBE2G2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2G2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    endoplasmic reticulum5
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol IDA16780588

    Find genes that share ontologies with UBE2G2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2G2 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Parkin-Ubiquitin Proteasomal System pathway
    Proteolysis Role of Parkin in the Ubiquitin Proteasomal Pathway0.89
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.57
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum
    5Parkinsons Disease Pathway
    Parkinsons Disease Pathway


    Find genes that share SuperPaths with UBE2G2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for UBE2G2
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 BioSystems Pathways for UBE2G2
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway

    1 Reactome Pathway for UBE2G2
        Antigen processing: Ubiquitination & Proteasome degradation


    3 Kegg Pathways  (Kegg details for UBE2G2):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2G2_HUMAN, P60604
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2G2: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBE2G2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2G2 (P606043 ENSP000003383484) via UniProtKB, MINT, STRING, and/or I2D (see all 375)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138383I2D: score=1 
    ENSG00000215425Q138383I2D: score=1 
    ENSG00000225073Q138383I2D: score=1 
    ENSG00000225859Q138383I2D: score=1 
    ENSG00000229496Q138383I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS9693041
    GO:0018279protein N-linked glycosylation via asparagine IMP--
    GO:0030433ER-associated ubiquitin-dependent protein catabolic process IMP--
    GO:0070936protein K48-linked ubiquitination IDA--

    Find genes that share ontologies with UBE2G2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2G2 (UB2G2)

    4 HMDB Compounds for UBE2G2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2G2 gene (3 alternative transcripts): 
    NM_001202489.1  NM_003343.5  NM_182688.2  

    Unigene Cluster for UBE2G2:

    Ubiquitin-conjugating enzyme E2G 2
    Hs.529420  [show with all ESTs]
    Unigene Representative Sequence: AK122700
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481546 ENST00000345496(uc002zfx.3 uc002zfy.3 uc021wjt.1)
    ENST00000497630 ENST00000477954 ENST00000491513 ENST00000330942 ENST00000478200
    ENST00000497664 ENST00000462569 ENST00000490450 ENST00000496395 ENST00000490091

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    Selected qRT-PCR Assays for microRNAs that regulate UBE2G2 (see all 24):
    hsa-miR-3910 hsa-miR-137 hsa-let-7d hsa-miR-1263 hsa-miR-4263 hsa-let-7c hsa-let-7g hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidUBE2G2 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 3): UBE2G2 (NM_003343)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2G2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2G2
    Addgene plasmids for UBE2G2 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2G2
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2G2
      QuantiFast Probe-based Assays in human, mouse, rat UBE2G2

    Additional mRNA sequence: 

    AK075143.1 AK122700.1 AK290629.1 AL355686.1 AL834129.1 BC001738.1 BC008351.1 BC011569.1 
    BC054341.1 BT006914.1 

    20 DOTS entries:

    DT.121132559  DT.92449943  DT.454521  DT.100840051  DT.40116400  DT.424690  DT.438750  DT.100030109 
    DT.121132538  DT.95226324  DT.100778705  DT.100778709  DT.121132556  DT.92449941  DT.92449945  DT.95226297 
    DT.100695636  DT.100778710  DT.121132557  DT.97760262 

    Selected AceView cDNA sequences (see all 379):

    NM_182688 CK822080 AI076609 BP358889 AW731802 AA700565 BU181670 AL355686 
    CK822081 AW068356 AA449337 AI610393 BQ775429 BU191548 CK430987 AA659503 
    BC008351 AA354384 BU184932 AL042072 CR620689 AV648697 CD367486 AW188157 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                      -     -     -     -     -     -                           
    SP2:                                      -     -                 -     -                           
    SP3:                                      -                                                         
    SP4:              -     -     -           -     -     -     -     -     -                           
    SP5:                                                                                                


    ECgene alternative splicing isoforms for UBE2G2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2G2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCCCTGT
    UBE2G2 Expression
    About this image


    UBE2G2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
    UBE2G2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2G2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.529420
        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2G2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2G2
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2G2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2G2
    QuantiTect SYBR Green Assays in human, mouse, rat UBE2G2
    QuantiFast Probe-based Assays in human, mouse, rat UBE2G2
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2G2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE2G2 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2g21 , 5 ubiquitin-conjugating enzyme E2G 21, 5 89.49(n)1
    100(a)1
      10 (39.72 cM)5
    222131  NM_019803.31  NP_062777.21 
     776222755 
    chicken
    (Gallus gallus)
    Aves UBE2G21 ubiquitin-conjugating enzyme E2G 2 82.42(n)
    98.18(a)
      424837  NM_001277419.1  NP_001264348.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2G26
    ubiquitin-conjugating enzyme E2G 2
    98(a)
    1 ↔ 1
    3(33838700-33858072)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ075407.12   -- 81.28(n)    BJ075407.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI981821.12   -- 77.3(n)   336349  BI981821.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta crl1 , 3 ubiquitin cycle ubiquitin conjugating
    enzyme3
    courtless1
    80(a)3
    71.72(n)1
    81.82(a)1
      2 14F13
    440541  NM_079945.31  NP_524684.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-141 , 3 ubc-141 74(a)3
    65.05(n)1
    76.97(a)1
      I(13589760-13593263)3
    1732281  NM_060980.41  NP_493381.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC7(YMR022W)4
    UBC71
    Ubiquitin conjugating enzyme, involved in the ER-associated more4
    UBC71
    56.57(n)1
    62.42(a)1
      13(318680-319177)4
    8550361, 4  NP_013735.11, 4 


    ENSEMBL Gene Tree for UBE2G2 (if available)
    TreeFam Gene Tree for UBE2G2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2G2 gene
    UBE2G12  CDC342  UBE2R22  
    Selected SIMAP similar genes for UBE2G2 using alignment to 3 protein entries:     UB2G2_HUMAN (see all proteins) (see all similar genes):
    DKFZp586L2318    UBE2G1    CDC34    UBE2D3    UBE2D2    UBE2A
    UBE2D1    UBE2B    UBE2D4    HR6A    UBE2R2    UBE2DNL
    UBE2E3    UBE2N    UBE2E1    UBE2K    UBE2L3    UBE2E2

    Find genes that share paralogs with UBE2G2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2G2 (see all 767)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828665871,2
    --31597414(+) CACAGC/TTTAAC 3 -- us2k10--------
    rs99776841,2
    C,F,H--31597428(+) TGTTAT/CACGGT 3 -- us2k115Minor allele frequency- C:0.14NS EA NA WA 1880
    rs1883843121,2
    --31597430(+) TTATAC/TGGTGG 3 -- us2k10--------
    rs732329611,2
    --31597455(+) CATCAC/TGCGTT 3 -- us2k10--------
    rs1499222531,2
    --31597456(+) ATCACA/C/GCGTTT 3 -- us2k10--------
    rs1430519571,2
    --31597575(+) GGGACA/CCCAGG 3 -- us2k10--------
    rs99802031,2
    C,F--31597653(+) GTCAGT/CTTCAC 3 -- us2k11Minor allele frequency- C:0.09WA 118
    rs44310261,2
    C--31597717(+) ACCATC/TTGCAT 3 -- us2k1 tfbs30--------
    rs99774801,2
    C,F--31597814(+) AGGCAC/TGAGGA 3 -- us2k13Minor allele frequency- T:0.14NA WA 240
    rs749612261,2
    C,F--31597836(+) CAGGAG/ATCTGA 3 -- us2k12Minor allele frequency- A:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for UBE2G2 (46188495 - 46221934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for UBE2G2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv459298CNV Loss19166990
    nsv913963CNV Loss21882294
    dgv4777n71CNV Loss21882294
    dgv4775n71CNV Loss21882294
    dgv4776n71CNV Loss21882294
    nsv913959CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603124    OMIM disorders: --

    1 disease for UBE2G2:    
    About MalaCards
    cri-du-chat syndrome

    1 disease from the University of Copenhagen DISEASES database for UBE2G2:
    Cri-Du-Chat syndrome

    Find genes that share disorders with UBE2G2           About GenesLikeMe

    Genetic Association Database (GAD): UBE2G2

    Export disorders for UBE2G2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2G2 gene, integrated from 10 sources (see all 61):
    (articles sorted by number of sources associating them with UBE2G2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae UBC7 gene. (PubMed id 9693041)1, 2, 3, 9 Katsanis N. and Fisher E.M.C. (Genomics 1998)
    2. Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). (PubMed id 16582478)1, 2, 9 Arai R.... Yokoyama S. (Acta Crystallogr. F 2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M.... Yaspo M.-L. (Nature 2000)
    6. Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization. (PubMed id 9925943)1, 3 Rose S.A....Robinson P.A. (Cytogenet. Cell Genet. 1998)
    7. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. (PubMed id 17310145)1, 9 Li W....Ye Y. (Nature 2007)
    8. Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. (PubMed id 20014027)1, 9 Ju T....Tolman J.R. (Proteins 2010)
    9. Dimeric Ube2g2 simultaneously engages donor and acceptor ubiquitins to form Lys48-linked ubiquitin chains. (PubMed id 24366945)1 Liu W....Li W. (EMBO J. 2014)
    10. Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. (PubMed id 23370391)1 Mallampalli R.K....Chen B.B. (Cell Cycle 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7327 HGNC: 12483 AceView: UBE2G2 Ensembl:ENSG00000184787 euGenes: HUgn7327
    ECgene: UBE2G2 Kegg: 7327 H-InvDB: UBE2G2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2G2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2G2 gene:
    Search GeneIP for patents involving UBE2G2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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