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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2G2 Gene

protein-coding   GIFtS: 68
GCID: GC21M046188

Ubiquitin-Conjugating Enzyme E2G 2

(Previous names: ubiquitin-conjugating enzyme E2G 2 (homologous to yeast...)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2G 21 2     UBC72 5
Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7)1 2     Human Ubiquitin Conjugating Enzyme G211
Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast)1 2     Ubiquitin Conjugating Enzyme 72
Ubiquitin Carrier Protein G22 3     Ubiquitin Conjugating Enzyme G22
Ubiquitin-Protein Ligase G22 3     Ubiquitin-Conjugating Enzyme E2 G22
EC 6.3.2.193 8     

External Ids:    HGNC: 124831   Entrez Gene: 73272   Ensembl: ENSG000001847877   OMIM: 6031245   UniProtKB: P606043   

Export aliases for UBE2G2 gene to outside databases

Previous GC identifers: GC21M042698 GC21M045045 GC21M045013 GC21M031563


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2G2 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100%
sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in
adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this
gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for UBE2G2 Gene: 
UBE2G2 (ubiquitin-conjugating enzyme E2G 2) is a protein-coding gene. Diseases associated with UBE2G2 include cri-du-chat syndrome, and parkinson's disease, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is UBE2G1.

UniProtKB/Swiss-Prot: UB2G2_HUMAN, P60604
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD)

Gene Wiki entry for UBE2G2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2G2 gene promoter:
         AREB6   MEF-2A   p53   AML1a   Bach2   aMEF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2G2 promoter sequence

   Search SABiosciences Chromatin IP Primers for UBE2G2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2G2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
UBE2G2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2G2 gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21M046188:   GeneLoc Nature:405,311-319
Start:
46,188,495 bp from pter       31,698,366 bp from centromere
End:
46,221,934 bp from pter 31,731,118 bp from centromere
Size:
33,440 bases 32,753 bases
Orientation:
minus strand minus strand

Whole chromosome sequencing:
cDNA sequence: AF032456
genomic clones: P225L15


(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2G2_HUMAN, P60604 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 G2  
Size: 165 amino acids; 18566 Da
3 PDB 3D structures from and Proteopedia for UBE2G2:
2CYX (3D)        2KLY (3D)        3H8K (3D)    
Secondary accessions: A6NMQ7 A8K3L4 D3DSL7 P56554
Alternative splicing: 2 isoforms:  P60604-1   P60604-2   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for UBE2G2: NX_P60604

Explore proteomics data for UBE2G2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60604

  • 4/5 DME Specific Peptides for UBE2G2 (P60604) (see all 5)
     VCISILH  DYPLSPPK  HPNIYPDG  SMLAEPNDESGAN 

    UBE2G2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2G2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001189418.1  NP_003334.2  NP_872630.1  

    ENSEMBL proteins: 
     ENSP00000338348   ENSP00000418423   ENSP00000331384   ENSP00000420671  
    Reactome Protein details: P60604
    Human Recombinant Protein Products for UBE2G2: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBE2G2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IEA--
    GO:0005829cytosol IDA16780588

    UBE2G2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P60604

    ProtoNet protein and cluster: P60604

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2G2_HUMAN, P60604
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2G2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2G2_HUMAN, P60604
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2G2:
    ubiquitin conjugating enzyme,homolog to yeast UBC7,with two transcript,ubiquitously expressed

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI17681147
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2G2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2G2:
     Increased S DNA content  Increased cell death in HCC-19  Upregulation of Wnt/beta-caten 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidUBE2G2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2G2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway
    Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway0.93
    Parkin-Ubiquitin Proteasomal System pathway0.89
    3Immune System
    Immune System0.56
    Adaptive Immune System0.56
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Parkinson's disease0.61
    5Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UBE2G2
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway


    1 GeneGo (Thomson Reuters) Pathway for UBE2G2
        Proteolysis Role of Parkin in the Ubiquitin-Proteasomal Pathway

    2 BioSystems Pathways for UBE2G2
        Parkin-Ubiquitin Proteasomal System pathway
    Parkinsons Disease Pathway

    4        Reactome Pathways for UBE2G2
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    3         Kegg Pathways  (Kegg details for UBE2G2):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Parkinson's disease

    UniProtKB/Swiss-Prot: UB2G2_HUMAN, P60604
    Pathway: Protein modification; protein ubiquitination


    UBE2G2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2G2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/293 Interacting proteins for UBE2G2 (P606043 ENSP000003383484) via UniProtKB, MINT, STRING, and/or I2D (see all 293)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDX39BQ138383I2D: score=1 
    ENSG00000215425Q138383I2D: score=1 
    ENSG00000225073Q138383I2D: score=1 
    ENSG00000225859Q138383I2D: score=1 
    ENSG00000229496Q138383I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS9693041
    GO:0018279protein N-linked glycosylation via asparagine IMP--
    GO:0030433ER-associated protein catabolic process IMP--
    GO:0070936protein K48-linked ubiquitination IDA--

    UBE2G2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2G2 (UB2G2)

    4 HMDB Compounds for UBE2G2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2G2 / UB2G2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2G2 gene (3 alternative transcripts): 
    NM_001202489.1  NM_003343.5  NM_182688.2  

    Unigene Clusters for UBE2G2:

    Ubiquitin-conjugating enzyme E2G 2
    Hs.529420  [show with all ESTs], Hs.701398  [show with all ESTs]
    Unigene Representative Sequences: AK122700, BC017241
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000481546 ENST00000345496(uc002zfx.3 uc002zfy.3 uc021wjt.1)
    ENST00000497630 ENST00000477954 ENST00000491513 ENST00000330942 ENST00000478200
    ENST00000497664 ENST00000462569 ENST00000490450 ENST00000496395 ENST00000490091


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    Additional mRNA sequence: BC017241.2 

    20 DOTS entries:

    DT.121132559  DT.454521  DT.92449943  DT.100840051  DT.40116400  DT.424690  DT.438750  DT.100030109 
    DT.121132538  DT.95226324  DT.100778705  DT.100778709  DT.121132556  DT.92449941  DT.92449945  DT.95226297 
    DT.100695636  DT.100778710  DT.121132557  DT.97760262 

    24/379 AceView cDNA sequences (see all 379):

    CK430987 AA700565 BU184932 BU630302 CR620689 BU181670 CA748881 AA354384 
    AI076609 AW068356 AV648697 AW731802 BM312498 AA449337 BP358889 NM_182688 
    CR622633 AI610393 BC008351 BC011569 BU782522 BQ775429 CR593095 AL355686 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c
    SP1:                                      -     -     -     -     -     -                           
    SP2:                                      -     -                 -     -                           
    SP3:                                      -                                                         
    SP4:              -     -     -           -     -     -     -     -     -                           
    SP5:                                                                                                


    ECgene alternative splicing isoforms for UBE2G2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2G2 expression in normal human tissues (normalized intensities)      UBE2G2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGTCCCTGT
    UBE2G2 Expression
    About this image


    UBE2G2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             brain/hindbrain   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Eye (Sensory Organs)
             lens   
     
     Hair (Integumentary System)
             mouse/organ system/integumental system   
     
     Tooth
             mouse/organ system/integumental system   

    See UBE2G2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2G2

    SOURCE GeneReport for Unigene clusters: Hs.529420 Hs.701398
        SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2G2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Unfolded Protein Response in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE2G2 gene from 8/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2g21 , 5 ubiquitin-conjugating enzyme E2G 21, 5 89.49(n)1
    100(a)1
      10 (39.72 cM)5
    222131  NM_019803.31  NP_062777.21 
     776222755 
    chicken
    (Gallus gallus)
    Aves UBE2G21 ubiquitin-conjugating enzyme E2G 2 82.42(n)
    98.18(a)
      424837  XM_422648.3  XP_422648.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2G26
    Uncharacterized protein
    98(a)
    1 ↔ 1
    3(33838700-33858072)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ075407.12   -- 81.28(n)    BJ075407.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI981821.12   -- 77.3(n)   336349  BI981821.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta crl1 , 3 ubiquitin cycle ubiquitin conjugating
    enzyme3
    courtless1
    80(a)3
    71.72(n)1
    81.82(a)1
      2 14F13
    440541  NM_079945.21  NP_524684.21 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-141 , 3 Protein UBC-141 74(a)3
    65.05(n)1
    76.97(a)1
      I(13589760-13593263)3
    1732281  NM_060980.31  NP_493381.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC7(YMR022W)4
    UBC71
    Ubiquitin conjugating enzyme, involved in the ER-associated more4
    Ubc7p1
    56.71(n)1
    62.8(a)1
      13(318680-319177)4
    8550361, 4  NP_013735.11, 4 


    ENSEMBL Gene Tree for UBE2G2 (if available)
    TreeFam Gene Tree for UBE2G2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2G2 gene
    UBE2G12  CDC342  UBE2R22  
    18/25 SIMAP similar genes for UBE2G2 using alignment to 3 protein entries:     UB2G2_HUMAN (see all proteins) (see all similar genes):
    DKFZp586L2318    UBE2G1    UBE2D3    UBE2D2    UBE2A    UBE2D1
    UBE2B    UBE2D4    CDC34    HR6A    UBE2R2    UBE2DNL
    UBE2E3    UBE2N    UBE2E1    UBE2K    UBE2L3    UBE2E2

    UBE2G2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/767 SNPs in UBE2G2 are shown (see all 767)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1828665871,2
    --31597414(+) CACAGC/TTTAAC 3 -- us2k10--------
    rs99776841,2
    C,F,H--31597428(+) TGTTAT/CACGGT 3 -- us2k115Minor allele frequency- C:0.14NS EA NA WA 1880
    rs1883843121,2
    --31597430(+) TTATAC/TGGTGG 3 -- us2k10--------
    rs732329611,2
    --31597455(+) CATCAC/TGCGTT 3 -- us2k10--------
    rs1499222531,2
    --31597456(+) ATCACA/C/GCGTTT 3 -- us2k10--------
    rs1430519571,2
    --31597575(+) GGGACA/CCCAGG 3 -- us2k10--------
    rs99802031,2
    C,F--31597653(+) GTCAGT/CTTCAC 3 -- us2k11Minor allele frequency- C:0.09WA 118
    rs44310261,2
    C--31597717(+) ACCATC/TTGCAT 3 -- us2k1 tfbs30--------
    rs99774801,2
    C,F--31597814(+) AGGCAC/TGAGGA 3 -- us2k13Minor allele frequency- T:0.14NA WA 240
    rs749612261,2
    C,F--31597836(+) CAGGAG/ATCTGA 3 -- us2k12Minor allele frequency- A:0.03CSA WA 120

    HapMap Linkage Disequilibrium report for UBE2G2 (46188495 - 46221934 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for UBE2G2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv459298CNV Loss19166990
    nsv913963CNV Loss21882294
    dgv4777n71CNV Loss21882294
    dgv4775n71CNV Loss21882294
    dgv4776n71CNV Loss21882294
    nsv913959CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603124    OMIM disorders: --

    4 diseases for UBE2G2:    About MalaCards
    cri-du-chat syndrome    parkinson's disease    ischemia    cerebritis

    1 disease from the University of Copenhagen DISEASES database for UBE2G2:
    Cri-Du-Chat syndrome

    UBE2G2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): UBE2G2

    Export disorders for UBE2G2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2G2 gene, integrated from 9 sources (see all 59):
    (articles sorted by number of sources associating them with UBE2G2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae UBC7 gene. (PubMed id 9693041)1, 2, 3, 9 Katsanis N. and Fisher E.M.C. (1998)
    2. Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). (PubMed id 16582478)1, 2, 9 Arai R.... Yokoyama S. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence of human chromosome 21. (PubMed id 10830953)1, 2 Hattori M....Yaspo M.L. (2000)
    6. Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization. (PubMed id 9925943)1, 3 Rose S.A....Robinson P.A. (1998)
    7. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. (PubMed id 17310145)1, 9 Li W....Ye Y. (2007)
    8. Solution structure and dynamics of human ubiquitin co njugating enzyme Ube2g2. (PubMed id 20014027)1, 9 Ju T....Tolman J.R. (2010)
    9. Calmodulin protects Aurora B on the midbody to regulat e the fidelity of cytokinesis. (PubMed id 23370391)1 Mallampalli R.K....Chen B.B. (2013)
    10. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7327 HGNC: 12483 AceView: UBE2G2 Ensembl:ENSG00000184787 euGenes: HUgn7327
    ECgene: UBE2G2 Kegg: 7327 H-InvDB: UBE2G2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2G2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2G2 gene:
    Search GeneIP for patents involving UBE2G2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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