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Aliases for UBE2G2 Gene

Aliases for UBE2G2 Gene

  • Ubiquitin Conjugating Enzyme E2 G2 2 3
  • Ubiquitin-Conjugating Enzyme E2G 2 (Homologous To Yeast UBC7) 2 3
  • Ubiquitin-Conjugating Enzyme E2G 2 (UBC7 Homolog, Yeast) 2 3
  • Ubiquitin Conjugating Enzyme E2G 2 3 5
  • E2 Ubiquitin-Conjugating Enzyme G2 3 4
  • Ubiquitin Carrier Protein G2 3 4
  • Ubiquitin-Protein Ligase G2 3 4
  • Ubiquitin-Conjugating Enzyme E2G 2 2
  • Ubiquitin Conjugating Enzyme G2 3
  • Ubiquitin Conjugating Enzyme 7 3
  • EC 63
  • EC 4
  • UBC7 3

External Ids for UBE2G2 Gene

Previous GeneCards Identifiers for UBE2G2 Gene

  • GC21M042698
  • GC21M045045
  • GC21M045013
  • GC21M046188
  • GC21M031563

Summaries for UBE2G2 Gene

Entrez Gene Summary for UBE2G2 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for UBE2G2 Gene

UBE2G2 (Ubiquitin Conjugating Enzyme E2 G2) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include identical protein binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2R2.

UniProtKB/Swiss-Prot for UBE2G2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).

Gene Wiki entry for UBE2G2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2G2 Gene

Genomics for UBE2G2 Gene

Regulatory Elements for UBE2G2 Gene

Enhancers for UBE2G2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2G2 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2G2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2G2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2G2 Gene

44,768,580 bp from pter
44,802,019 bp from pter
33,440 bases
Minus strand

Genomic View for UBE2G2 Gene

Genes around UBE2G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2G2 Gene

Proteins for UBE2G2 Gene

  • Protein details for UBE2G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 G2
    Protein Accession:
    Secondary Accessions:
    • A6NMQ7
    • A8K3L4
    • D3DSL7
    • P56554

    Protein attributes for UBE2G2 Gene

    165 amino acids
    Molecular mass:
    18566 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2G2 Gene

    Alternative splice isoforms for UBE2G2 Gene


neXtProt entry for UBE2G2 Gene

Proteomics data for UBE2G2 Gene at MOPED

Selected DME Specific Peptides for UBE2G2 Gene

Post-translational modifications for UBE2G2 Gene

  • Ubiquitination at Lys 153 and Lys 156
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2G2 Gene

Domains & Families for UBE2G2 Gene

Gene Families for UBE2G2 Gene

Protein Domains for UBE2G2 Gene

Suggested Antigen Peptide Sequences for UBE2G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family.
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2G2: view

Function for UBE2G2 Gene

Molecular function for UBE2G2 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme,homolog to yeast UBC7,with two transcript,ubiquitously expressed
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).

Enzyme Numbers (IUBMB) for UBE2G2 Gene

Gene Ontology (GO) - Molecular Function for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with UBE2G2: view
genes like me logo Genes that share phenotypes with UBE2G2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2G2

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2G2 Gene

Localization for UBE2G2 Gene

Subcellular locations from

Jensen Localization Image for UBE2G2 Gene COMPARTMENTS Subcellular localization image for UBE2G2 gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBE2G2 Gene

Pathways & Interactions for UBE2G2 Gene

genes like me logo Genes that share pathways with UBE2G2: view

UniProtKB/Swiss-Prot P60604-UB2G2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0018279 protein N-linked glycosylation via asparagine IMP 22607976
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IMP 22607976
GO:0035458 cellular response to interferon-beta IMP 24882218
GO:1904153 negative regulation of retrograde protein transport, ER to cytosol IMP 25660456
genes like me logo Genes that share ontologies with UBE2G2: view

No data available for SIGNOR curated interactions for UBE2G2 Gene

Drugs & Compounds for UBE2G2 Gene

(3) Drugs for UBE2G2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with UBE2G2: view

Transcripts for UBE2G2 Gene

Unigene Clusters for UBE2G2 Gene

Ubiquitin-conjugating enzyme E2G 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - -
SP6: - - - -

Relevant External Links for UBE2G2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2G2 Gene

mRNA expression in normal human tissues for UBE2G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2G2 Gene

This gene is overexpressed in Bone (15.8) and Breast (10.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2G2 Gene

SOURCE GeneReport for Unigene cluster for UBE2G2 Gene Hs.529420

genes like me logo Genes that share expression patterns with UBE2G2: view

Protein tissue co-expression partners for UBE2G2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2G2 Gene

Orthologs for UBE2G2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2G2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBE2G2 35
  • 91.52 (n)
  • 99.39 (a)
UBE2G2 36
  • 99 (a)
(Canis familiaris)
Mammalia UBE2G2 35
  • 90.71 (n)
  • 95.76 (a)
UBE2G2 36
  • 96 (a)
(Mus musculus)
Mammalia Ube2g2 35
  • 89.49 (n)
  • 100 (a)
Ube2g2 16
Ube2g2 36
  • 100 (a)
(Pan troglodytes)
Mammalia UBE2G2 35
  • 99.39 (n)
  • 100 (a)
UBE2G2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ube2g2 35
  • 89.49 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia UBE2G2 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2G2 36
  • 90 (a)
(Gallus gallus)
Aves UBE2G2 35
  • 82.42 (n)
  • 98.18 (a)
UBE2G2 36
  • 98 (a)
(Anolis carolinensis)
Reptilia UBE2G2 36
  • 98 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2g2 35
  • 82.22 (n)
  • 96.36 (a)
(Danio rerio)
Actinopterygii -- 35
ube2g2 35
  • 78.18 (n)
  • 92.73 (a)
ube2g2 36
  • 94 (a)
fruit fly
(Drosophila melanogaster)
Insecta crl 37
  • 80 (a)
crl 35
  • 71.72 (n)
  • 81.82 (a)
crl 36
  • 81 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002169 35
  • 70.91 (n)
  • 82.42 (a)
(Caenorhabditis elegans)
Secernentea ubc-14 37
  • 74 (a)
ubc-14 35
  • 65.05 (n)
  • 76.97 (a)
ubc-14 36
  • 75 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABR059W 35
  • 60.61 (n)
  • 62.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E07745g 35
  • 57.17 (n)
  • 59.39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC7 35
  • 56.57 (n)
  • 62.42 (a)
UBC7 36
  • 62 (a)
UBC7 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3185 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03623 35
  • 59.71 (n)
  • 63.19 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc7 35
  • 60.25 (n)
  • 68.32 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 79 (a)
Species with no ortholog for UBE2G2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2G2 Gene

Gene Tree for UBE2G2 (if available)
Gene Tree for UBE2G2 (if available)

Paralogs for UBE2G2 Gene

Paralogs for UBE2G2 Gene

genes like me logo Genes that share paralogs with UBE2G2: view

Variants for UBE2G2 Gene

Sequence variations from dbSNP and Humsavar for UBE2G2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1071792 -- 44,770,495(-) GGTAG(C/T)AGTGA utr-variant-3-prime
rs235267 -- 44,790,864(+) ggtag(C/T)aggca intron-variant
rs235268 -- 44,791,472(+) ggtac(A/C)gctca intron-variant
rs235269 -- 44,791,749(-) gttgt(C/T)ctctt intron-variant
rs235270 -- 44,793,166(-) CTGCC(A/G/T)TAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2G2 Gene

Variant ID Type Subtype PubMed ID
dgv4775n71 CNV Loss 21882294
nsv913959 CNV Loss 21882294
dgv4776n71 CNV Loss 21882294
nsv913963 CNV Loss 21882294
nsv459298 CNV Loss 19166990
dgv4777n71 CNV Loss 21882294

Variation tolerance for UBE2G2 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.07; 1.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBE2G2 Gene

Disorders for UBE2G2 Gene

Relevant External Links for UBE2G2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBE2G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2G2 Gene

Publications for UBE2G2 Gene

  1. Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae UBC7 gene. (PMID: 9693041) Katsanis N. … Fisher E.M.C. (Genomics 1998) 2 3 4 23 67
  2. Solution structure and dynamics of human ubiquitin conjugating enzyme Ube2g2. (PMID: 20014027) Ju T. … Tolman J.R. (Proteins 2010) 3 23
  3. A ubiquitin ligase transfers preformed polyubiquitin chains from a conjugating enzyme to a substrate. (PMID: 17310145) Li W. … Ye Y. (Nature 2007) 3 23
  4. Structure of human ubiquitin-conjugating enzyme E2 G2 (UBE2G2/UBC7). (PMID: 16582478) Arai R. … Yokoyama S. (Acta Crystallogr. F 2006) 3 23
  5. Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization. (PMID: 9925943) Rose S.A. … Robinson P.A. (Cytogenet. Cell Genet. 1998) 2 3

Products for UBE2G2 Gene

Sources for UBE2G2 Gene