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Aliases for UBE2G1 Gene

Aliases for UBE2G1 Gene

  • Ubiquitin Conjugating Enzyme E2 G1 2 3 5
  • Ubiquitin-Conjugating Enzyme E2G 1 (Homologous To C. Elegans UBC7) 2 3
  • Ubiquitin-Conjugating Enzyme E2G 1 (UBC7 Homolog, C. Elegans) 2 3
  • Ubiquitin-Conjugating Enzyme E2G 1 (UBC7 Homolog, Yeast) 2 3
  • E2 Ubiquitin-Conjugating Enzyme G1 3 4
  • Ubiquitin Carrier Protein G1 3 4
  • Ubiquitin-Protein Ligase G1 3 4
  • UBE2G 3 4
  • E217K 3 4
  • UBC7 3 4
  • Ubiquitin-Conjugating Enzyme E2G 1 2
  • Ubiquitin Conjugating Enzyme E2G 1 3
  • Ubiquitin-Conjugating Enzyme E2 G1 3
  • EC 6.3.2.19 61
  • EC 2.3.2.23 4

External Ids for UBE2G1 Gene

Previous HGNC Symbols for UBE2G1 Gene

  • UBE2G

Previous GeneCards Identifiers for UBE2G1 Gene

  • GC17M004492
  • GC17M004124
  • GC17M004380
  • GC17M004120
  • GC17M004061

Summaries for UBE2G1 Gene

Entrez Gene Summary for UBE2G1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2G1 Gene

UBE2G1 (Ubiquitin Conjugating Enzyme E2 G1) is a Protein Coding gene. Among its related pathways are Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2R2.

UniProtKB/Swiss-Prot for UBE2G1 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-, as well as Lys-63-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.

Gene Wiki entry for UBE2G1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2G1 Gene

Genomics for UBE2G1 Gene

Regulatory Elements for UBE2G1 Gene

Enhancers for UBE2G1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F004393 1.5 FANTOM5 Ensembl ENCODE 2.7 -29.1 -29095 4.6 HDGF TBP TBL1XR1 RAD21 RFX5 ZNF366 SCRT2 ETV6 CREM CBFB LINC01975 UBE2G1 MYBBP1A GC17P004368 SPNS3
GH17F003913 1.3 FANTOM5 ENCODE 2.7 +451.0 450975 4.6 HDGF PKNOX1 ATF1 SIN3A ZNF48 ZNF2 ZNF121 GLIS2 ELK1 ZNF143 P2RX1 ATP2A3 P2RX5 ZZEF1 UBE2G1 GC17M003905
GH17F004373 1.5 FANTOM5 Ensembl ENCODE 2.2 -8.5 -8454 2.7 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 YBX1 BMI1 EGR1 SCRT2 ETV6 ANKFY1 CYB5D2 UBE2G1 GC17P004368 SPNS3
GH17F004847 1.5 FANTOM5 Ensembl ENCODE 2.2 -484.7 -484662 7.9 PKNOX1 ZBTB40 RAD21 RFX5 RARA RCOR1 FOS THAP11 EGR2 ZNF263 CHRNE ENO3 ZMYND15 PFN1 ARRB2 C17orf107 RNF167 PLD2 CXCL16 LOC101559451
GH17F004174 0.9 FANTOM5 Ensembl ENCODE 3.4 +189.4 189350 5.5 HLF ZZEF1 CYB5D2 ATP2A3 TM4SF5 UBE2G1 P2RX1 NCBP3 PIR35722 PIR52300
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2G1 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2G1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001339486 874 2801 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for UBE2G1 Gene

Chromosome:
17
Start:
4,269,217 bp from pter
End:
4,366,674 bp from pter
Size:
97,458 bases
Orientation:
Minus strand

Genomic View for UBE2G1 Gene

Genes around UBE2G1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2G1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2G1 Gene

Proteins for UBE2G1 Gene

  • Protein details for UBE2G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62253-UB2G1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 G1
    Protein Accession:
    P62253
    Secondary Accessions:
    • B2R7P2
    • D3DTK0
    • Q99462

    Protein attributes for UBE2G1 Gene

    Size:
    170 amino acids
    Molecular mass:
    19509 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26288.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2G1 Gene

neXtProt entry for UBE2G1 Gene

Selected DME Specific Peptides for UBE2G1 Gene

P62253:
  • GPPDTLYEGG
  • FPKDYPL
  • DSPANVDAAK
  • VCISILH

Post-translational modifications for UBE2G1 Gene

  • Ubiquitination at Lys 63, Lys 73, Lys 101, and Lys 163
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2G1 Gene

Domains & Families for UBE2G1 Gene

Gene Families for UBE2G1 Gene

Suggested Antigen Peptide Sequences for UBE2G1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62253

UniProtKB/Swiss-Prot:

UB2G1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2G1: view

Function for UBE2G1 Gene

Molecular function for UBE2G1 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2G,highly homolog to C elegans UBC7,highly expressed in skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-, as well as Lys-63-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.

Enzyme Numbers (IUBMB) for UBE2G1 Gene

Gene Ontology (GO) - Molecular Function for UBE2G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0031625 ubiquitin protein ligase binding IPI 11439185
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with UBE2G1: view
genes like me logo Genes that share phenotypes with UBE2G1: view

Animal Models for UBE2G1 Gene

MGI Knock Outs for UBE2G1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2G1 Gene

Localization for UBE2G1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2G1 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 2
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBE2G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UBE2G1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2G1 Gene

Pathways & Interactions for UBE2G1 Gene

genes like me logo Genes that share pathways with UBE2G1: view

UniProtKB/Swiss-Prot P62253-UB2G1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8893823
GO:0016567 protein ubiquitination IEA --
GO:0044257 cellular protein catabolic process IMP 21628527
GO:0070534 protein K63-linked ubiquitination IDA 20061386
GO:0070936 protein K48-linked ubiquitination IDA 14593114
genes like me logo Genes that share ontologies with UBE2G1: view

No data available for SIGNOR curated interactions for UBE2G1 Gene

Drugs & Compounds for UBE2G1 Gene

(3) Drugs for UBE2G1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2G1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2G1: view

Transcripts for UBE2G1 Gene

Unigene Clusters for UBE2G1 Gene

Ubiquitin-conjugating enzyme E2G 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for UBE2G1 Gene

GeneLoc Exon Structure for
UBE2G1
ECgene alternative splicing isoforms for
UBE2G1

Expression for UBE2G1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2G1 Gene

mRNA differential expression in normal tissues according to GTEx for UBE2G1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.5).

Protein differential expression in normal tissues from HIPED for UBE2G1 Gene

This gene is overexpressed in Plasma (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2G1 Gene



Protein tissue co-expression partners for UBE2G1 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2G1 Gene:

UBE2G1

SOURCE GeneReport for Unigene cluster for UBE2G1 Gene:

Hs.741319

mRNA Expression by UniProt/SwissProt for UBE2G1 Gene:

P62253-UB2G1_HUMAN
Tissue specificity: Widely expressed, mainly in skeletal muscle.
genes like me logo Genes that share expression patterns with UBE2G1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UBE2G1 Gene

Orthologs for UBE2G1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2G1 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2G1 35
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2G1 35
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2G1 34 35
  • 97.72 (n)
rat
(Rattus norvegicus)
Mammalia Ube2g1 34
  • 95.69 (n)
cow
(Bos Taurus)
Mammalia UBE2G1 34 35
  • 95.29 (n)
mouse
(Mus musculus)
Mammalia Ube2g1 34 16 35
  • 95.29 (n)
dog
(Canis familiaris)
Mammalia UBE2G1 34 35
  • 94.02 (n)
chicken
(Gallus gallus)
Aves UBE2G1 34 35
  • 88.63 (n)
lizard
(Anolis carolinensis)
Reptilia UBE2G1 35
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2g1 34
  • 84.71 (n)
MGC75869 34
African clawed frog
(Xenopus laevis)
Amphibia ube2g1-prov 34
zebrafish
(Danio rerio)
Actinopterygii ube2g1a 34 35
  • 84.9 (n)
wufi33c04 34
fruit fly
(Drosophila melanogaster)
Insecta CG9602 36 35
  • 77 (a)
CG40045 34 35
  • 74.34 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002251 34
  • 69.9 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-7 36 35
  • 74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC7 35
  • 50 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC13 34
  • 64.6 (n)
soybean
(Glycine max)
eudicotyledons Gma.3757 34
rice
(Oryza sativa)
Liliopsida Os05g0460200 34
  • 61.49 (n)
Os.12603 34
barley
(Hordeum vulgare)
Liliopsida Hv.12670 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 73 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc15 34
  • 64.85 (n)
Species where no ortholog for UBE2G1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2G1 Gene

ENSEMBL:
Gene Tree for UBE2G1 (if available)
TreeFam:
Gene Tree for UBE2G1 (if available)

Paralogs for UBE2G1 Gene

Paralogs for UBE2G1 Gene

Pseudogenes.org Pseudogenes for UBE2G1 Gene

genes like me logo Genes that share paralogs with UBE2G1: view

Variants for UBE2G1 Gene

Sequence variations from dbSNP and Humsavar for UBE2G1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1017445 -- 4,316,663(+) GACAC(A/G)GGCTA intron-variant
rs1045734 -- 4,270,114(-) TGGAA(G/T)TGAGA utr-variant-3-prime
rs1045738 -- 4,269,648(-) TTGAC(G/T)TGTCA utr-variant-3-prime
rs10536668 -- 4,316,334(+) TAGAT(-/AGAC)AGACC intron-variant
rs10593474 -- 4,279,276(+) ATCTC(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2G1 Gene

Variant ID Type Subtype PubMed ID
nsv833345 CNV loss 17160897
nsv821134 CNV duplication 20802225
nsv515940 CNV gain+loss 19592680
nsv1066651 CNV gain 25217958
nsv1065237 CNV gain 25217958
nsv1058176 CNV gain 25217958
esv3892955 CNV gain 25118596
esv3639774 CNV loss 21293372
esv3639773 CNV gain 21293372
esv3639772 CNV gain 21293372
esv3368111 CNV duplication 20981092
esv2762544 CNV gain 21179565
esv2715552 CNV deletion 23290073
esv2660255 CNV deletion 23128226
dgv509n67 CNV loss 20364138

Variation tolerance for UBE2G1 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2G1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2G1 Gene

Disorders for UBE2G1 Gene

Relevant External Links for UBE2G1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2G1

No disorders were found for UBE2G1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2G1 Gene

Publications for UBE2G1 Gene

  1. Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. (PMID: 8893823) Watanabe T.K. … Takahashi E. (Cytogenet. Cell Genet. 1996) 2 3 4 64
  2. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64
  5. Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. (PMID: 12933904) Kim B.W. … Bianco A.C. (Mol. Endocrinol. 2003) 3 22 64

Products for UBE2G1 Gene

Sources for UBE2G1 Gene

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