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Aliases for UBE2G1 Gene

Aliases for UBE2G1 Gene

  • Ubiquitin-Conjugating Enzyme E2G 1 2 3
  • UBE2G 3 4 6
  • Ubiquitin-Conjugating Enzyme E2G 1 (Homologous To C. Elegans UBC7) 2 3
  • Ubiquitin-Conjugating Enzyme E2G 1 (UBC7 Homolog, C. Elegans) 2 3
  • Ubiquitin-Conjugating Enzyme E2G 1 (UBC7 Homolog, Yeast) 2 3
  • Ubiquitin Carrier Protein G1 3 4
  • Ubiquitin-Protein Ligase G1 3 4
  • EC 6.3.2.19 4 63
  • E217K 3 4
  • UBC7 3 4
  • Ubiquitin-Conjugating Enzyme E2 G1 3

External Ids for UBE2G1 Gene

Previous HGNC Symbols for UBE2G1 Gene

  • UBE2G

Previous GeneCards Identifiers for UBE2G1 Gene

  • GC17M004492
  • GC17M004124
  • GC17M004380
  • GC17M004120
  • GC17M004061

Summaries for UBE2G1 Gene

Entrez Gene Summary for UBE2G1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2G1 Gene

UBE2G1 (Ubiquitin-Conjugating Enzyme E2G 1) is a Protein Coding gene. Diseases associated with UBE2G1 include cri-du-chat syndrome. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2R2.

UniProtKB/Swiss-Prot for UBE2G1 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-, as well as Lys-63-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.

Gene Wiki entry for UBE2G1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2G1 Gene

Genomics for UBE2G1 Gene

Regulatory Elements for UBE2G1 Gene

Genomic Location for UBE2G1 Gene

Start:
4,269,217 bp from pter
End:
4,366,674 bp from pter
Size:
97,458 bases
Orientation:
Minus strand

Genomic View for UBE2G1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2G1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2G1 Gene

Proteins for UBE2G1 Gene

  • Protein details for UBE2G1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62253-UB2G1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 G1
    Protein Accession:
    P62253
    Secondary Accessions:
    • B2R7P2
    • D3DTK0
    • Q99462

    Protein attributes for UBE2G1 Gene

    Size:
    170 amino acids
    Molecular mass:
    19509 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH26288.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBE2G1 Gene

neXtProt entry for UBE2G1 Gene

Proteomics data for UBE2G1 Gene at MOPED

Selected DME Specific Peptides for UBE2G1 Gene

Post-translational modifications for UBE2G1 Gene

  • Ubiquitination at Lys63, Lys73, Lys101, and Lys163
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2G1 Gene

Domains for UBE2G1 Gene

Gene Families for UBE2G1 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2G1 Gene

Suggested Antigen Peptide Sequences for UBE2G1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62253

UniProtKB/Swiss-Prot:

UB2G1_HUMAN :
  • P62253
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2G1: view

Function for UBE2G1 Gene

Molecular function for UBE2G1 Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme E2G,highly homolog to C elegans UBC7,highly expressed in skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-, as well as Lys-63-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.

Enzyme Numbers (IUBMB) for UBE2G1 Gene

Gene Ontology (GO) - Molecular Function for UBE2G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0019787 ubiquitin-like protein transferase activity IBA --
genes like me logo Genes that share ontologies with UBE2G1: view

Phenotypes for UBE2G1 Gene

genes like me logo Genes that share phenotypes with UBE2G1: view

miRNA for UBE2G1 Gene

miRTarBase miRNAs that target UBE2G1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2G1 Gene

Localization for UBE2G1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2G1 Gene COMPARTMENTS Subcellular localization image for UBE2G1 gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for UBE2G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with UBE2G1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2G1 Gene

Pathways for UBE2G1 Gene

genes like me logo Genes that share pathways with UBE2G1: view

UniProtKB/Swiss-Prot P62253-UB2G1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2G1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8893823
GO:0008152 metabolic process --
GO:0044257 cellular protein catabolic process IMP 21628527
GO:0070534 protein K63-linked ubiquitination IDA 20061386
GO:0070936 protein K48-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2G1: view

Compounds for UBE2G1 Gene

(4) HMDB Compounds for UBE2G1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2G1: view

Transcripts for UBE2G1 Gene

Unigene Clusters for UBE2G1 Gene

Ubiquitin-conjugating enzyme E2G 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c
SP1: -
SP2: - - - -
SP3: -
SP4: -
SP5: - -
SP6:

Relevant External Links for UBE2G1 Gene

GeneLoc Exon Structure for
UBE2G1
ECgene alternative splicing isoforms for
UBE2G1

Expression for UBE2G1 Gene

mRNA expression in normal human tissues for UBE2G1 Gene

mRNA differential expression in normal tissues according to GTEx for UBE2G1 Gene

This gene is overexpressed in Muscle - Skeletal (5.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2G1 Gene

SOURCE GeneReport for Unigene cluster for UBE2G1 Gene Hs.741319

mRNA Expression by UniProt/SwissProt for UBE2G1 Gene

P62253-UB2G1_HUMAN
Tissue specificity: Widely expressed, mainly in skeletal muscle.
genes like me logo Genes that share expressions with UBE2G1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for UBE2G1 Gene

Orthologs for UBE2G1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2G1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2G1 35
  • 97.72 (n)
  • 96.27 (a)
UBE2G1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2G1 35
  • 95.29 (n)
  • 100 (a)
UBE2G1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2G1 35
  • 94.02 (n)
  • 99.36 (a)
UBE2G1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2g1 35
  • 95.29 (n)
  • 100 (a)
Ube2g1 16
Ube2g1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2G1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2G1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2g1 35
  • 95.69 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves UBE2G1 35
  • 88.63 (n)
  • 100 (a)
UBE2G1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2G1 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ube2g1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75869 35
ube2g1 35
  • 84.71 (n)
  • 99.41 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2g1a 35
  • 84.9 (n)
  • 98.82 (a)
ube2g1a 36
  • 99 (a)
OneToOne
wufi33c04 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002251 35
  • 69.9 (n)
  • 84.24 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG40045 35
  • 74.34 (n)
  • 84.24 (a)
CG40045 36
  • 83 (a)
OneToMany
CG9602 36
  • 77 (a)
OneToMany
CG9602 37
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-7 36
  • 73 (a)
OneToOne
ubc-7 37
  • 74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC7 36
  • 50 (a)
OneToMany
soybean
(Glycine max)
eudicotyledons Gma.3757 35
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC13 35
  • 64.6 (n)
  • 63.98 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.12670 35
rice
(Oryza sativa)
Liliopsida Os.12603 35
Os05g0460200 35
  • 61.49 (n)
  • 62.73 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc15 35
  • 64.85 (n)
  • 66.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 73 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
Species with no ortholog for UBE2G1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2G1 Gene

ENSEMBL:
Gene Tree for UBE2G1 (if available)
TreeFam:
Gene Tree for UBE2G1 (if available)

Paralogs for UBE2G1 Gene

Paralogs for UBE2G1 Gene

Pseudogenes.org Pseudogenes for UBE2G1 Gene

genes like me logo Genes that share paralogs with UBE2G1: view

Variants for UBE2G1 Gene

Sequence variations from dbSNP and Humsavar for UBE2G1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8568 -- 4,269,288(-) TCTAT(A/G)AATCA utr-variant-3-prime
rs733622 -- 4,277,827(+) AAGCC(A/G)TGAGA intron-variant
rs747018 -- 4,293,496(+) tgttc(C/G)agttt intron-variant
rs893380 -- 4,294,739(+) gtgaa(A/G)ccccg intron-variant
rs893381 -- 4,294,933(+) ACGTA(A/C)GTgag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2G1 Gene

Variant ID Type Subtype PubMed ID
nsv907588 CNV Gain 21882294
dgv509n67 CNV Loss 20364138
nsv821134 CNV Duplication 20802225
nsv515940 CNV Gain+Loss 19592680
esv2715552 CNV Deletion 23290073
dgv3046n71 CNV Gain 21882294
nsv907592 CNV Gain 21882294
nsv833345 CNV Loss 17160897
esv2660255 CNV Deletion 23128226

Relevant External Links for UBE2G1 Gene

HapMap Linkage Disequilibrium report
UBE2G1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2G1 Gene

Disorders for UBE2G1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for UBE2G1 Gene including...

Search for UBE2G1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for UBE2G1 Gene

genes like me logo Genes that share disorders with UBE2G1: view

No data available for UniProtKB/Swiss-Prot for UBE2G1 Gene

Publications for UBE2G1 Gene

  1. Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. (PMID: 8893823) Watanabe T.K. … Takahashi E. (Cytogenet. Cell Genet. 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4
  4. Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. (PMID: 12933904) Kim B.W. … Bianco A.C. (Mol. Endocrinol. 2003) 3 23
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4

Products for UBE2G1 Gene

Sources for UBE2G1 Gene

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