UBE2G1 Gene
protein-coding GIFtS: 60
GC17M004120
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ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) (Previous names: ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7), ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) ) Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: UBE2G)
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Aliases & Descriptions for UBE2G1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
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| Aliases |
|---|
| E217K 2, 3 | | EC 6.3.2.19 3 | | UBC7 2, 3 | | UBE2G 2, 3 |
| | | Descriptions |
|---|
| Ubiquitin carrier protein G1 2, 3 | | Ubiquitin-protein ligase G1 2, 3 | | ubiquitin-conjugating enzyme E2G 1 2 | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans) 1, 2 | | ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) 2 | ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7) 1, 2 |
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| | Search outside databases for aliases for UBE2G1 genePrevious GC identifers: GC17M004492 GC17M004124 GC17M004380 |
Summaries for UBE2G1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for UBE2G1: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq] UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Function: Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteinsGene Wiki entry for UBE2G1 |
Genomic Location for UBE2G1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBE2G1 gene 
Entrez Gene cytogenetic band: 1q42|17p13.2 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.2UBE2G1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M004120:
(about GC identifiers)
Start:
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4,119,261 bp from pter |
End:
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4,216,718 bp from pter |
Size:
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97,458 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010718.15
| Proteins for UBE2G1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 G1 Size: 170 amino acids; 19509 Da
PDB structures from and Proteopedia :2AWF (3D)
 
Secondary accessions: Q99462Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003333.1
ENSEMBL proteins: ENSP00000254724 ENSP00000380178
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for UBE2G1: Assays for UBE2G1: | Protein
Domains/ Families for UBE2G1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P62253
ProtoNet protein and cluster: P62253 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Similarity: Belongs to the ubiquitin-conjugating enzyme family | Gene Function for UBE2G1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003342
Applied Biosystems Silencer® siRNAs for UBE2G1
Sigma-Aldrich siRNA and siRNA Panels for UBE2G1  Sigma-Aldrich shRNA Panels and shRNA for UBE2G1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003342                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003342                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003342 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003342
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Function: Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of muscle-specific proteinsCatalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.19 Genatlas biochemistry entry for UBE2G1:ubiquitin conjugating enzyme E2G,highly homolog to C elegans UBC7,highly expressed in skeletal muscle2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- | | GO:0016874 | ligase activity |
IEA | -- | About this table | Pathways & Interactions for UBE2G1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2G1 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Pathway: Protein modification; protein ubiquitination 1 Interacting protein for UBE2G1 (ENSP000002547243) via UniProtKB, MINT, and/or STRINGAbout this table
3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0006511 | ubiquitin-dependent protein catabolic process |
TAS | 8893823 | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | About this table
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Drugs & Compounds for UBE2G1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
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Browse Tocris compounds for UBE2G1
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Transcripts for UBE2G1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003342
Sigma-Aldrich siRNA and siRNA Panels for UBE2G1  Sigma-Aldrich shRNA Panels and shRNA for UBE2G1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003342 REFSEQ mRNAs for UBE2G1 gene: NM_003342.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003342               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003342                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003342                                  untagged cDNA clones in CMV expression vector (see all 2): NM_003342  Additional cDNA sequence: AK313059.1 BC002775.2 BC017006.1 BC026288.1 BT007416.1 CR622319.1 CR623407.1 D78514.1 10 DOTS entries: DT.444928 DT.97847027 DT.95333171 DT.100789880 DT.100789882 DT.91751363 DT.120910165 DT.445070 DT.75172367 DT.91742715 24/350 AceView cDNA sequences (see all 350
):BQ924413 BM723498 BG112905 CR623407 BC026288 AW150446 BG677778 BG676464 AW008557 Z42296 AI364886 AW499792 BU568576 BC002775 BU161770 Z42739 BF982430 BE673128 AA721173 BI858731 AI928773 AW016088 AA593118 AL138101
highest scoring ESTs for UBE2G1:D78514 AA113903 AU137034 BE396516 BE898059 BF981447 BG112905 BG115232 BG116490 BG289576 Unigene Cluster for UBE2G1: Ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast) Hs.714345 [show with all ESTs]Unigene Representative Sequence: NM_003342
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2G1 (see all 6
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| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBE2G1
2 Ensembl transcripts including schematic representations: ENST00000254724
ENST00000396981
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Expression for UBE2G1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBE2G1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBE2G1
1 / 2 / 3 9 probe-sets matching UBE2G1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGATGAGTGC
SOURCE GeneReport for Unigene cluster: Hs.714345 UniProtKB/Swiss-Prot: UB2G1_HUMAN, P62253Tissue specificity: Widely expressed, mainly in skeletal muscle |
Orthologs for UBE2G1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
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Orthologs for UBE2G1 gene from 5/22 species (see all 22
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About this table Species with no ortholog for UBE2G1
ENSEMBL Gene Tree for UBE2G1 | Paralogs for UBE2G1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBE2G1 gene
- UBE2G22
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SNPs/Variants for UBE2G1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for UBE2G1 (up to first 250kb)
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Disorders & Mutations for UBE2G1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 601569
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Medical News for UBE2G1(Possibly Related Articles in
Doctor's Guide)
About This Section
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Publications for UBE2G1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/14 PubMed articles for UBE2G1 gene (see all 14
):- Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. (PubMed id 8893823)2, 3, 4 Watanabe T.K.... Takahashi E. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)3, 4 Gevaert K.... Vandekerckhove J. (2003)
- Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. (PubMed id 12933904)1, 3 Kim B.W....Bianco A.C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. (PubMed id 11439185)3 Imai Y.... Takahashi R. (2001)
- Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). (PubMed id 11278356)3 Tiwari S. and Weissman A.M. (2001)
- Biochemistry. Ubiquitination--more than two to tango. (PubMed id 11032556)3 Joazeiro C.A. and Hunter T. (2000)
- The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. (PubMed id 10521492)3 Moynihan T.P....Robinson P.A. (1999)
- Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. (PubMed id 10558980)3 Huang L.... Pavletich N.P. (1999)
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Search for UBE2G1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing UBE2G1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBE2G1
(According to HUGE)
About This Section
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Specialized Databases showing UBE2G1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| About This Section
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| Services for UBE2G1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
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 Products for UBE2G1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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