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Aliases for UBE2F Gene

Aliases for UBE2F Gene

  • Ubiquitin Conjugating Enzyme E2 F (Putative) 2 3 5
  • Ubiquitin-Conjugating Enzyme E2F (Putative) 2 3
  • RING-Type E3 NEDD8 Transferase UBE2F 3 4
  • NEDD8 Carrier Protein UBE2F 3 4
  • NEDD8 Protein Ligase UBE2F 3 4
  • NEDD8-Conjugating Enzyme 2 3 4
  • NCE2 3 4
  • Ubiquitin-Conjugating Enzyme E2 F 4
  • NEDD8-Conjugating Enzyme UBE2F 3
  • NEDD8 Conjugating Enzyme 2
  • EC 2.3.2.- 4
  • EC 6.3.2 61

External Ids for UBE2F Gene

Previous GeneCards Identifiers for UBE2F Gene

  • GC00U990541
  • GC02P238658
  • GC02P238540
  • GC02P238875
  • GC02P230667
  • GC02P237967
  • GC02P237969
  • GC02P237970
  • GC02P237971
  • GC02P237972

Summaries for UBE2F Gene

GeneCards Summary for UBE2F Gene

UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene. Among its related pathways are Cell cycle and Innate Immune System. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F-SCLY.

UniProtKB/Swiss-Prot for UBE2F Gene

  • Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2F Gene

Genomics for UBE2F Gene

Regulatory Elements for UBE2F Gene

Enhancers for UBE2F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G237963 1.7 FANTOM5 Ensembl ENCODE 24.9 -0.1 -52 6.2 MLX CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 UBE2F SCLY ILKAP RAMP1 ESPNL KLHL30 ASB1 HES6 LRRFIP1 GC02P237964
GH02G237940 1.2 Ensembl ENCODE 21.6 -24.8 -24807 4.6 PKNOX1 ATF1 SIN3A TCF12 ZNF766 CBX5 GATA2 CAVIN1 NCOA1 REST UBE2F ESPNL RAMP1 ILKAP SCLY LOC105373960 GC02P237963 GC02P237974 GC02P237975 PIR54851
GH02G238097 1.1 Ensembl ENCODE 17.6 +133.0 132981 5.1 HNRNPUL1 HDGF PKNOX1 AGO1 DEAF1 RAD21 GLIS2 EGR1 FOS EGR2 ESPNL UBE2F KLHL30 SCLY HES6
GH02G237997 0.9 ENCODE 21 +31.7 31720 1.8 PKNOX1 TBL1XR1 ZSCAN4 YBX1 PLRG1 RFX5 RELB IKZF2 CREM EGR2 UBE2F RNU6-1333P SCLY ESPNL RAMP1 ILKAP UBE2F-SCLY
GH02G237922 1.4 Ensembl ENCODE dbSUPER 12.4 -43.5 -43527 1.9 ATF1 RB1 FUS ARID4B DMAP1 ZNF48 RAD21 ZNF143 FOS U2AF2 UBE2F RAMP1 SCLY LOC105373960 ENSG00000263723
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2F on UCSC Golden Path with GeneCards custom track

Promoters for UBE2F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000132764 255 1601 HDGF HNRNPUL1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for UBE2F Gene

Chromosome:
2
Start:
237,966,827 bp from pter
End:
238,042,782 bp from pter
Size:
75,956 bases
Orientation:
Plus strand

Genomic View for UBE2F Gene

Genes around UBE2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2F Gene

Proteins for UBE2F Gene

  • Protein details for UBE2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M7-UBE2F_HUMAN
    Recommended name:
    NEDD8-conjugating enzyme UBE2F
    Protein Accession:
    Q969M7
    Secondary Accessions:
    • A8K1Z8
    • B4DDT9
    • B4DFI1
    • B4DMK3
    • B4DZU2
    • B8ZZG2
    • C9J212
    • H9KVB9

    Protein attributes for UBE2F Gene

    Size:
    185 amino acids
    Molecular mass:
    21077 Da
    Quaternary structure:
    • Interacts with UBA3 and RBX2.

    Three dimensional structures from OCA and Proteopedia for UBE2F Gene

    Alternative splice isoforms for UBE2F Gene

neXtProt entry for UBE2F Gene

Selected DME Specific Peptides for UBE2F Gene

Q969M7:
  • GGKFQFE
  • IWHPNITETGEICLSLLREHS
  • DGTGWAPTRTLKDVVWGLNSLFTDLLNF
  • AYNMVPPKVKCLT
  • EVAELEANLP
  • DPLNIEAAEHHL

Post-translational modifications for UBE2F Gene

  • The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UBE2F Gene

Gene Families for UBE2F Gene

Suggested Antigen Peptide Sequences for UBE2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969M7

UniProtKB/Swiss-Prot:

UBE2F_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
genes like me logo Genes that share domains with UBE2F: view

Function for UBE2F Gene

Molecular function for UBE2F Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-NEDD8yl-[E2 NEDD8-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 NEDD8-conjugating enzyme]-L-cysteine + N(6)-NEDD8yl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

Enzyme Numbers (IUBMB) for UBE2F Gene

Gene Ontology (GO) - Molecular Function for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19250909
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0019788 NEDD8 transferase activity TAS,IDA --
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with UBE2F: view
genes like me logo Genes that share phenotypes with UBE2F: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2F

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2F

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2F Gene

Localization for UBE2F Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2F gene
Compartment Confidence
cytosol 3
extracellular 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2F Gene

Pathways & Interactions for UBE2F Gene

genes like me logo Genes that share pathways with UBE2F: view

UniProtKB/Swiss-Prot Q969M7-UBE2F_HUMAN

  • Pathway: Protein modification; protein neddylation.

Gene Ontology (GO) - Biological Process for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
GO:0045116 protein neddylation IEA --
genes like me logo Genes that share ontologies with UBE2F: view

No data available for SIGNOR curated interactions for UBE2F Gene

Drugs & Compounds for UBE2F Gene

(3) Drugs for UBE2F Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2F Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2F: view

Transcripts for UBE2F Gene

Unigene Clusters for UBE2F Gene

Ubiquitin-conjugating enzyme E2F (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2F

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2F Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:

Relevant External Links for UBE2F Gene

GeneLoc Exon Structure for
UBE2F
ECgene alternative splicing isoforms for
UBE2F

Expression for UBE2F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2F Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Platelet (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2F Gene



Protein tissue co-expression partners for UBE2F Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2F Gene:

UBE2F

SOURCE GeneReport for Unigene cluster for UBE2F Gene:

Hs.471785

mRNA Expression by UniProt/SwissProt for UBE2F Gene:

Q969M7-UBE2F_HUMAN
Tissue specificity: Widely expressed (at protein level).

Evidence on tissue expression from TISSUES for UBE2F Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with UBE2F: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2F Gene

Orthologs for UBE2F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2F 34
  • 99.82 (n)
-- 35
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
UBE2F 34
  • 92.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ube2f 34 16 35
  • 92.25 (n)
Gm5434 35
  • 89 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ube2f 34
  • 91.62 (n)
cow
(Bos Taurus)
Mammalia UBE2F 34 35
  • 90.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves UBE2F 34 35
  • 85.95 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2f 34
  • 78.56 (n)
Str.15431 34
zebrafish
(Danio rerio)
Actinopterygii ube2f 34 35
  • 74.05 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012193 34
  • 57.66 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-12 34 35
  • 52.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC12 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3148 35
  • 48 (a)
OneToMany
Species where no ortholog for UBE2F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2F Gene

ENSEMBL:
Gene Tree for UBE2F (if available)
TreeFam:
Gene Tree for UBE2F (if available)

Paralogs for UBE2F Gene

Variants for UBE2F Gene

Sequence variations from dbSNP and Humsavar for UBE2F Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000011574 -- 237,984,385(+) TTTGT(C/T)TCCCA intron-variant
rs1000012568 -- 238,026,050(+) GGGCT(G/T)TATTT intron-variant
rs1000024575 -- 238,023,706(+) CCTTT(A/C)TGATG intron-variant
rs1000061179 -- 237,991,405(+) TTTGG(A/G)GCTCT intron-variant
rs1000071563 -- 237,986,080(+) TTAAT(A/C)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2F Gene

Variant ID Type Subtype PubMed ID
dgv4193n100 CNV gain 25217958
nsv1000252 CNV loss 25217958
nsv1011723 CNV gain 25217958
nsv214866 CNV deletion 16902084
nsv508205 CNV deletion 20534489
nsv979190 CNV duplication 23825009

Variation tolerance for UBE2F Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2F Gene

Human Gene Mutation Database (HGMD)
UBE2F
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2F Gene

Disorders for UBE2F Gene

Relevant External Links for UBE2F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2F

No disorders were found for UBE2F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2F Gene

Publications for UBE2F Gene

  1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PMID: 19250909) Huang D.T. … Schulman B.A. (Mol. Cell 2009) 2 3 4 22 64
  2. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda J.K. … Schulman B.A. (Structure 2013) 2 3 4 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for UBE2F Gene

  • Addgene plasmids for UBE2F

Sources for UBE2F Gene

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