Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2F Gene

protein-coding   GIFtS: 58
GCID: GC02P238875

Ubiquitin-Conjugating Enzyme E2F (Putative)

Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2F (Putative)1 2     NEDD8 Conjugating Enzyme1
NCE22 3     NEDD8-Conjugating Enzyme UBE2F2
NEDD8 Carrier Protein UBE2F2 3     EC 6.3.2.-3
NEDD8 Protein Ligase UBE2F2 3     Ubiquitin-Conjugating Enzyme E2 F3
NEDD8-Conjugating Enzyme 22 3     EC 6.3.28

External Ids:    HGNC: 124801   Entrez Gene: 1407392   Ensembl: ENSG000001841827   UniProtKB: Q969M73   

Export aliases for UBE2F gene to outside databases

Previous GC identifers: GC00U990541 GC02P238658 GC02P238540 GC02P230667


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBE2F Gene: 
UBE2F (ubiquitin-conjugating enzyme E2F (putative)) is a protein-coding gene. Diseases associated with UBE2F include breast cancer, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include NEDD8 ligase activity and ATP binding. An important paralog of this gene is UBE2F-SCLY.

UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent
attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests
that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.2  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2F gene promoter:
         TBP   AML1a   FOXD1   LUN-1   HNF-3beta   RORalpha2   GATA-6   TFIID   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UBE2F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

UBE2F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2F gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P238875:  view genomic region     (about GC identifiers)

Start:
238,875,469 bp from pter      End:
238,951,423 bp from pter
Size:
75,955 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7 (See protein sequence)
Recommended Name: NEDD8-conjugating enzyme UBE2F  
Size: 185 amino acids; 21077 Da
Subunit: Interacts with UBA3 and RBX2
3 PDB 3D structures from and Proteopedia for UBE2F:
2EDI (3D)        3FN1 (3D)        4GBA (3D)    
Secondary accessions: A8K1Z8 B4DDT9 B4DFI1 B4DMK3 B4DZU2 B8ZZG2
Alternative splicing: 5 isoforms:  Q969M7-1   Q969M7-2   Q969M7-3   Q969M7-4   Q969M7-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2F: NX_Q969M7

Explore proteomics data for UBE2F at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969M7

  • 4/6 DME Specific Peptides for UBE2F (Q969M7) (see all 6)
     GGKFQFE  EVAELEANLP  DPLNIEAAEHHL  AYNMVPPKVKCLT 

    UBE2F Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2F Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001265234.1  NP_001265235.1  NP_001265236.1  NP_001265237.1  NP_542409.1  

    ENSEMBL proteins: 
     ENSP00000412965   ENSP00000409749   ENSP00000272930   ENSP00000410867   ENSP00000396003  
     ENSP00000390813   ENSP00000387299   ENSP00000389685   ENSP00000408823   ENSP00000396296  
     ENSP00000410345   ENSP00000396630   ENSP00000408676   ENSP00000393515   ENSP00000386680  
     ENSP00000387060   ENSP00000406113   ENSP00000414619   ENSP00000399183  
    Reactome Protein details: Q969M7
    Human Recombinant Protein Products for UBE2F: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UBE2F
    Enzo Life Sciences proteins for UBE2F
    OriGene Purified Protein for UBE2F
    OriGene Protein Over-expression Lysate for UBE2F
    OriGene MassSpec for UBE2F 
    OriGene Custom Protein Services for UBE2F
    GenScript Custom Purified and Recombinant Proteins Services for UBE2F
    Novus Biologicals UBE2F Proteins
    Novus Biologicals UBE2F Lysate
    Sino Biological Recombinant Protein for UBE2F
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBE2F 


    UBE2F Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for UBE2F
    GenScript Custom Superior Antibodies Services for UBE2F
    Novus Biologicals UBE2F Antibodies
    Abcam antibodies for UBE2F
    Cloud-Clone Corp. Antibodies for UBE2F 
    ThermoFisher Antibody for UBE2F
    LSBio Antibodies in human, mouse, rat for UBE2F 

    Assay Products for UBE2F: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBE2F
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBE2F
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBE2F 
    Cloud-Clone Corp. CLIAs for UBE2F


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q969M7

    ProtoNet protein and cluster: Q969M7

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily


    UBE2F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2F_HUMAN, Q969M7
    Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent
    attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests
    that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5
    Catalytic activity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19250909
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0019788NEDD8 ligase activity IDA19250909
         
    UBE2F for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2F:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2F 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2F

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2F 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2F 

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2F:
    hsa-mir-335 (MIRT004083)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2F
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2F (see all 36):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-136 hsa-miR-300 hsa-miR-139-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidUBE2F 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2F
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2F

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBE2F
    Sirion Biotech Customized adenovirus for overexpression of UBE2F

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UBE2F (see all 7)
    OriGene ORF clones in mouse, rat for UBE2F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2F (NM_080678)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2F
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2F 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2F 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBE2F
    Search LifeMap BioReagents cell lines for UBE2F
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2F


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2F About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for UBE2F
        Integrated Breast Cancer Pathway


    4        Reactome Pathways for UBE2F
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE2F):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Pathway: Protein modification; protein neddylation


    UBE2F for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for UBE2F (Q969M73 ENSP000002729304) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2B4Q9UI103, ENSP000003948694I2D: score=1 STRING: ENSP00000394869
    STAT1P422243, ENSP000003543944I2D: score=1 STRING: ENSP00000354394
    TYK2P295973, ENSP000002648184I2D: score=1 STRING: ENSP00000264818
    UBA3Q8TBC43, ENSP000003543404I2D: score=1 STRING: ENSP00000354340
    WDR77Q9BQA13, ENSP000002350904I2D: score=1 STRING: ENSP00000235090
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045116protein neddylation IEA--

    UBE2F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2F

    4 HMDB Compounds for UBE2F    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2F

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2F gene (5 alternative transcripts): 
    NM_001278305.1  NM_001278306.1  NM_001278307.1  NM_001278308.1  NM_080678.2  

    Unigene Cluster for UBE2F:

    Ubiquitin-conjugating enzyme E2F (putative)
    Hs.471785  [show with all ESTs]
    Unigene Representative Sequence: NR_037904
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000440223 ENST00000441728 ENST00000272930(uc002vxk.3 uc010zno.2 uc010znn.2 uc010znp.2)
    ENST00000433568 ENST00000448502 ENST00000416292 ENST00000409633 ENST00000455999
    ENST00000417231 ENST00000445676 ENST00000439338 ENST00000439780 ENST00000454786
    ENST00000433241 ENST00000409953 ENST00000409332 ENST00000434655 ENST00000434137

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2F
    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2F (see all 36):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-136 hsa-miR-300 hsa-miR-139-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidUBE2F 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2F
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2F
    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2F (see all 7)
    OriGene ORF clones in mouse, rat for UBE2F
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBE2F (NM_080678)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2F
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2F
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2F 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2F 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBE2F
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2F
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2F
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2F
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2F

    Additional mRNA sequence: 

    AF310723.1 AK290063.1 AK293334.1 AK294107.1 AK297502.1 AK303094.1 BC010549.1 BC039435.1 
    NR_037904.1 

    13 DOTS entries:

    DT.100825702  DT.100028467  DT.100825699  DT.95328589  DT.95194761  DT.121034236  DT.100825697  DT.100825706 
    DT.91712027  DT.95075373  DT.100825705  DT.100825711  DT.91712029 

    24/318 AceView cDNA sequences (see all 318):

    BM142247 BU193048 AI792322 AI082068 BM922883 BG818765 AA243769 AI123897 
    BU689854 AA179031 AI669951 CR605720 BC010549 BE018479 CF528949 AI272802 
    AA806862 AI688376 AW628238 CA413036 CB123239 BM793135 CR597637 CR597540 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2F    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                 
    SP2:                    -                                                   
    SP3:                                                                        


    ECgene alternative splicing isoforms for UBE2F

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2F expression in normal human tissues (normalized intensities)      UBE2F embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCTCATT
    UBE2F Expression
    About this image


    UBE2F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
     
     Skeletal Muscle (Muscoskeletal System)
             gastrocnemius muscle   

    See UBE2F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2F

    SOURCE GeneReport for Unigene cluster: Hs.471785

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Tissue specificity: Widely expressed (at protein level)

        SABiosciences Custom PCR Arrays for UBE2F
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2F
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2F
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2F
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2F
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2F
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE2F gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2f1 , 5 ubiquitin-conjugating enzyme E2F (putative)1, 5 92.25(n)1
    96.76(a)1
      1 (46.08 cM)5
    679211  NM_026454.31  NP_080730.11 
     912503195 
    chicken
    (Gallus gallus)
    Aves UBE2F1 ubiquitin-conjugating enzyme E2F (putative) 85.95(n)
    92.97(a)
      424015  NM_001006512.1  NP_001006512.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    1 → many
    1(117198570-117247629)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154312 Transcribed sequence with moderate similarity to protein more 79.81(n)    BX706738.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2f1 ubiquitin-conjugating enzyme E2F (putative) 74.05(n)
    82.16(a)
      406606  NM_213314.1  NP_998479.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0121931 AGAP012193-PA 57.66(n)
    65.41(a)
      1280493  XM_320339.4  XP_320339.4 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-121 Protein UBC-12 52.69(n)
    54.84(a)
      173072  NM_060623.3  NP_493024.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC126
    Enzyme that mediates the conjugation of Rub1p, a u...
    26(a)
    1 → many
    XII(744151-744851)


    ENSEMBL Gene Tree for UBE2F (if available)
    TreeFam Gene Tree for UBE2F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2F gene
    UBE2F-SCLY2  UBE2M2  
    15 SIMAP similar genes for UBE2F using alignment to 17 protein entries:     UBE2F_HUMAN (see all proteins):
    UBE2N    UBE2M    HR6A    UBE2G1    UBE2A    UBE2B
    UBE2K    UBE2D4    UBE2D1    UBE2S    UBE2D2    UBE2L3
    UBE2D3    UBE2E2    UBE2E3

    UBE2F for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for UBE2F
    PGOHUM00000248909 PGOHUM00000244849 PGOHUM00000247426 PGOHUM00000237587


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBE2F:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876062CNV Loss21882294
    nsv214866CNV Loss16902084
    nsv508205CNV Loss20534489

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2F
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2F

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for UBE2F:    About MalaCards
    breast cancer    


    UBE2F for disorders           About GeneDecksing


    Export disorders for UBE2F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2F gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with UBE2F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2, 9 Huang D.T....Schulman B.A. (2009)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. Structural conservation of distinctive N-terminal acet ylation-dependent interactions across a family of mammalian NEDD8 ligation enzym es. (PubMed id 23201271)1 Monda J.K....Schulman B.A. (2013)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Vif hijacks CBF-b to degrade APOBEC3G and promote HIV- 1 infection. (PubMed id 22190037)1 Jager S....Krogan N.J. (2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    9. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. (PubMed id 23300442)1 Stanley D.J....Gross J.D. (2012)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140739 HGNC: 12480 AceView: SCLYandNCE2 Ensembl:ENSG00000184182 euGenes: HUgn140739
    ECgene: UBE2F Kegg: 140739 H-InvDB: UBE2F

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2F gene:
    Search GeneIP for patents involving UBE2F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for UBE2F (UBE2F)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for UBE2F  
     OriGene qPCR primer pairs and template standards for UBE2F   OriGene Protein Over-expression Lysate for UBE2F  
     OriGene MassSpec something-or-other for UBE2F   OriGene clones in human, mouse for UBE2F  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBE2F   OriGene Purified Protein for UBE2F  
     OriGene ORF clones in mouse, rat for UBE2F   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBE2F   OriGene Custom Protein Services for UBE2F  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2F
     QIAGEN SeqTarget long-range PCR primers for resequencing UBE2F
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2F
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2F
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2F
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2F
     GenScript Custom Purified and Recombinant Proteins Services for UBE2F GenScript cDNA clones with any tag delivered in your preferred vector for UBE2F
     GenScript Custom Assay Services for UBE2F GenScript Custom Superior Antibodies Services for UBE2F
     GenScript Custom overexpressing Cell Line Services for UBE2F CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UBE2F promoter
     Search Chromatin IP Primers for UBE2F
     RT2 qPCR Primer Assay in human, mouse, rat UBE2F
     Search GNC Networks for UBE2F
     SABiosciences Custom PCR Arrays for UBE2F
     Search Tocris compounds for UBE2F
     Proteins and Antibodies for UBE2F
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for UBE2F
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UBE2F antibodies
     UBE2F proteins
     UBE2F lysates
     Antibodies for UBE2F
     See all of Abcam's Antibodies, Kits and Proteins for UBE2F
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UBE2F
     Antibodies for UBE2F
     ELISAs for UBE2F
     CLIAs for UBE2F
     Search LifeMap BioReagents cell lines for UBE2F
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2F
     SwitchGear 3'UTR luciferase reporter plasmids for UBE2F
     Browse SwitchGear Promoter luciferase reporter plasmids for UBE2F
     ThermoFisher Antibody for UBE2F
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2F
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2F
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2F
    Customized:
     lentivirus for stable overexpression of UBE2F
     lentivirus expression plasmids for stable overexpression of UBE2F
     adenovirus for overexpression of UBE2F
     LSBio Antibodies in human, mouse, rat for UBE2F
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBE2F gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4