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Aliases & Descriptions for UBE2F
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 6.3.2.- 3 | | MGC18120 2 | | NCE2 1, 2, 3 |
| | | Descriptions |
|---|
| NEDD8 carrier protein UBE2F 3 | | NEDD8 conjugating enzyme 2 | | NEDD8 protein ligase UBE2F 3 | | NEDD8-conjugating enzyme 2 | | NEDD8-conjugating enzyme 2 3 | | Ubiquitin-conjugating enzyme E2 F 3 | | ubiquitin-conjugating enzyme E2F (putative) 2 |
|
| | Search outside databases for aliases for UBE2F genePrevious GC identifers: GC00U990541 GC02P238658 |
Summaries for UBE2F(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5 |
Genomic Location for UBE2F
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBE2F gene 
Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3UBE2F Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P238540:
(about GC identifiers)
Start:
|
238,540,395 bp from pter |
End:
|
238,615,696 bp from pter |
Size:
|
75,302 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000002.10 NT_005120.15
| Proteins for UBE2F
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7 (See
protein sequence)Recommended Name: NEDD8-conjugating enzyme UBE2F Size: 185 amino acids; 21077 Da
Subunit: Interacts with UBA3 and RBX2
PDB structure from and Proteopedia :2EDI (3D)
 3FN1 (3D)
 
Secondary accessions: A8K1Z8 B4DDT9 B4DFI1 B4DMK3 B4DZU2 B8ZZG2Alternative splicing: 5 isoforms: Q969M7-1 Q969M7-2 Q969M7-3 Q969M7-4 Q969M7-5 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_542409.1
ENSEMBL proteins: ENSP00000386680 ENSP00000272930 ENSP00000387299 ENSP00000387060
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for UBE2F: Assays for UBE2F: | Protein
Domains/ Families for UBE2F(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q969M7
ProtoNet protein and cluster: Q969M7 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7Similarity: Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily | Gene Function for UBE2F
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080678
Applied Biosystems Silencer® siRNAs for UBE2F
Sigma-Aldrich siRNA and siRNA Panels for UBE2F  Sigma-Aldrich shRNA for UBE2F  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080678                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080678                                  untagged cDNA clone in CMV expression vector: NM_080678 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_080678
UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5Catalytic activity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysineEnzyme Number (IUBMB): EC 6.3.2.- 2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016874 | ligase activity |
IEA | -- | | GO:0019787 | small conjugating protein ligase activity |
IEA | -- | About this table | Pathways & Interactions for UBE2F
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2F (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7Pathway: Protein modification; protein neddylation3 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019941 | modification-dependent protein catabolic process |
IEA | -- | | GO:0043687 | post-translational protein modification |
IEA | -- | | GO:0051246 | regulation of protein metabolic process |
IEA | -- | About this table
|
Drugs & Compounds for UBE2F(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBE2F
|
Transcripts for UBE2F(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080678
Sigma-Aldrich siRNA and siRNA Panels for UBE2F  Sigma-Aldrich shRNA for UBE2F  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_080678 REFSEQ mRNAs for UBE2F gene: NM_080678.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_080678               OriGene GFP tagged cDNA clone in CMV expression vector: NM_080678                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080678                                  untagged cDNA clone in CMV expression vector: NM_080678  Additional cDNA sequence: AF310723.1 AK290063.1 AK293334.1 AK294107.1 AK297502.1 AK303094.1 BC010549.1 BC039435.1 CR615230.1 CR620417.1 13 DOTS entries: DT.100825702 DT.100028467 DT.95194761 DT.100825699 DT.95328589 DT.121034236 DT.100825697 DT.100825706 DT.91712027 DT.95075373 DT.100825705 DT.100825711 DT.91712029 24/318 AceView cDNA sequences (see all 318
):BP431575 BE504322 AI142222 CR605720 CR610086 BQ013232 CD107215 CR615230 AI082068 BM922883 BQ636945 BX117784 AI123897 CF528949 W60600 BM793135 AA179031 CR620417 AI791644 CB123239 AA243769 AI792322 AI688377 NM_080678
highest scoring ESTs for UBE2F:AV698767 BP210331 BP210878 BP316734 BX334820 CK819836 CN368271 CN368272 CN368273 CN370974 Unigene Cluster for UBE2F: Ubiquitin-conjugating enzyme E2F (putative) Hs.471785 [show with all ESTs]Unigene Representative Sequence: AK290063
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2F
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBE2F
4 Ensembl transcripts including schematic representations: ENST00000409953
ENST00000272930
ENST00000409633
ENST00000409332
|
Expression for UBE2F
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBE2F expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBE2F
1 / 2 / 3 11 probe-sets matching UBE2F gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACTGCTCATT
SOURCE GeneReport for Unigene cluster: Hs.471785 UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7Tissue specificity: Widely expressed (at protein level) |
Orthologs for UBE2F
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBE2F gene from 5/11 species (see all 11
)
About this table Species with no ortholog for UBE2F
ENSEMBL Gene Tree for UBE2F | Paralogs for UBE2F(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBE2F gene
- UBE2M2
Pseudogenes
- 4 related pseudogenes
|
SNPs/Variants for UBE2F(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBE2F (up to first 250kb)
|
Disorders & Mutations for UBE2F
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for UBE2F(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBE2F (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for UBE2F gene: |
Search for UBE2F
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBE2F
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBE2F
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2F(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBE2F(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBE2F:

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Incremental update: 13 Oct 2009
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