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UBE2F Gene

protein-coding   GIFtS: 58
GCID: GC02P238875

Ubiquitin-Conjugating Enzyme E2F (Putative)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2F (Putative)1 2     NEDD8 Conjugating Enzyme1
NCE22 3     NEDD8-Conjugating Enzyme UBE2F2
NEDD8 Carrier Protein UBE2F2 3     EC 6.3.2.-3
NEDD8 Protein Ligase UBE2F2 3     Ubiquitin-Conjugating Enzyme E2 F3
NEDD8-Conjugating Enzyme 22 3     EC 6.3.28

External Ids:    HGNC: 124801   Entrez Gene: 1407392   Ensembl: ENSG000001841827   UniProtKB: Q969M73   

Export aliases for UBE2F gene to outside databases

Previous GC identifers: GC00U990541 GC02P238658 GC02P238540 GC02P230667


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UBE2F Gene:
UBE2F (ubiquitin-conjugating enzyme E2F (putative)) is a protein-coding gene. Diseases associated with UBE2F include malaria, and hiv-1. GO annotations related to this gene include NEDD8 ligase activity. An important paralog of this gene is UBE2F-SCLY.

UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent
attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests
that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2F gene promoter:
         TBP   AML1a   FOXD1   LUN-1   HNF-3beta   RORalpha2   GATA-6   TFIID   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UBE2F

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

UBE2F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2F gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P238875:  view genomic region     (about GC identifiers)

Start:
238,875,469 bp from pter      End:
238,951,423 bp from pter
Size:
75,955 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7 (See protein sequence)
Recommended Name: NEDD8-conjugating enzyme UBE2F  
Size: 185 amino acids; 21077 Da
Subunit: Interacts with UBA3 and RBX2
3 PDB 3D structures from and Proteopedia for UBE2F:
2EDI (3D)        3FN1 (3D)        4GBA (3D)    
Secondary accessions: A8K1Z8 B4DDT9 B4DFI1 B4DMK3 B4DZU2 B8ZZG2
Alternative splicing: 5 isoforms:  Q969M7-1   Q969M7-2   Q969M7-3   Q969M7-4   Q969M7-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2F: NX_Q969M7

Explore proteomics data for UBE2F at MOPED

Post-translational modifications: 

  • The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8
    transfer to cullins1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2F (Q969M7) (see all 6)
     GGKFQFE  EVAELEANLP  DPLNIEAAEHHL  AYNMVPPKVKCLT 


    See UBE2F Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001265234.1  NP_001265235.1  NP_001265236.1  NP_001265237.1  NP_542409.1  

    ENSEMBL proteins: 
     ENSP00000412965   ENSP00000409749   ENSP00000272930   ENSP00000410867   ENSP00000396003  
     ENSP00000390813   ENSP00000387299   ENSP00000389685   ENSP00000408823   ENSP00000396296  
     ENSP00000410345   ENSP00000396630   ENSP00000408676   ENSP00000393515   ENSP00000386680  
     ENSP00000387060   ENSP00000406113   ENSP00000414619   ENSP00000399183  
    Reactome Protein details: Q969M7

    UBE2F Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q969M7

    ProtoNet protein and cluster: Q969M7

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily


    UBE2F for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2F_HUMAN, Q969M7
    Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent
    attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests
    that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5
    Catalytic activity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine

         Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19250909
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0019788NEDD8 ligase activity IDA19250909
         
    UBE2F for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2F:
     Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2F
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2F

    miRNA
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    miRTarBase miRNAs that target UBE2F:
    hsa-mir-129-5p (MIRT006660), hsa-mir-335-5p (MIRT004083), hsa-mir-129-2-3p (MIRT006661), hsa-mir-615-3p (MIRT040036)

    Block miRNA regulation of human, mouse, rat UBE2F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2F (see all 36):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-136 hsa-miR-300 hsa-miR-139-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidUBE2F 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBE2F
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2F

    Gene Editing
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    OriGene clones in human, mouse for UBE2F (see all 6)
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    GenScript: all cDNA clones in your preferred vector: UBE2F (NM_080678)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2F

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2F


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    extracellular2
    nucleus2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2F About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2F
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 BioSystems Pathway for UBE2F
        Integrated Breast Cancer Pathway


    1 Reactome Pathway for UBE2F
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for UBE2F):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Pathway: Protein modification; protein neddylation


    UBE2F for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBE2F
    Interactions:

        Search GeneGlobe Interaction Network for UBE2F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2F (Q969M73 ENSP000002729304) via UniProtKB, MINT, STRING, and/or I2D (see all 39)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2B4Q9UI103, ENSP000003948694I2D: score=1 STRING: ENSP00000394869
    STAT1P422243, ENSP000003543944I2D: score=1 STRING: ENSP00000354394
    TYK2P295973, ENSP000002648184I2D: score=1 STRING: ENSP00000264818
    UBA3Q8TBC43, ENSP000003543404I2D: score=1 STRING: ENSP00000354340
    WDR77Q9BQA13, ENSP000002350904I2D: score=1 STRING: ENSP00000235090
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045116protein neddylation IEA--

    UBE2F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2F

    4 HMDB Compounds for UBE2F    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBE2F gene (5 alternative transcripts): 
    NM_001278305.1  NM_001278306.1  NM_001278307.1  NM_001278308.1  NM_080678.2  

    Unigene Cluster for UBE2F:

    Ubiquitin-conjugating enzyme E2F (putative)
    Hs.471785  [show with all ESTs]
    Unigene Representative Sequence: NR_037904
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000440223 ENST00000441728 ENST00000272930(uc002vxk.3 uc010zno.2 uc010znn.2 uc010znp.2)
    ENST00000433568 ENST00000448502 ENST00000416292 ENST00000409633 ENST00000455999
    ENST00000417231 ENST00000445676 ENST00000439338 ENST00000439780 ENST00000454786
    ENST00000433241 ENST00000409953 ENST00000409332 ENST00000434655 ENST00000434137

    miRNA
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    Block miRNA regulation of human, mouse, rat UBE2F using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2F (see all 36):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-136 hsa-miR-300 hsa-miR-139-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidUBE2F 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2F
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2F
      QuantiFast Probe-based Assays in human, mouse, rat UBE2F

    Additional mRNA sequence: 

    AF310723.1 AK290063.1 AK293334.1 AK294107.1 AK297502.1 AK303094.1 BC010549.1 BC039435.1 
    NR_037904.1 

    13 DOTS entries:

    DT.100825702  DT.100028467  DT.100825699  DT.95328589  DT.95194761  DT.121034236  DT.100825697  DT.100825706 
    DT.91712027  DT.95075373  DT.100825705  DT.100825711  DT.91712029 

    Selected AceView cDNA sequences (see all 318):

    CF528949 AI688376 BE855458 BM922883 BC010549 BU633895 BM793135 AI424010 
    AI272802 W60600 AA806862 CA413036 CB123239 CR597637 CR597540 BM142018 
    AI734980 CR605720 BQ636945 AA602645 BP431575 BQ962765 BM142247 CR610086 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2F    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                 
    SP2:                    -                                                   
    SP3:                                                                        


    ECgene alternative splicing isoforms for UBE2F

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTGCTCATT
    UBE2F Expression
    About this image


    UBE2F expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    UBE2F Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2F Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.471785

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Tissue specificity: Widely expressed (at protein level)

        Custom PCR Arrays for UBE2F
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    QuantiFast Probe-based Assays in human, mouse, rat UBE2F
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBE2F gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2f1 , 5 ubiquitin-conjugating enzyme E2F (putative)1, 5 92.25(n)1
    96.76(a)1
      1 (46.08 cM)5
    679211  NM_026454.31  NP_080730.11 
     912503195 
    chicken
    (Gallus gallus)
    Aves UBE2F1 ubiquitin-conjugating enzyme E2F (putative) 85.95(n)
    92.97(a)
      424015  NM_001006512.1  NP_001006512.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    91(a)
    1 → many
    1(117198570-117247629)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154312 Transcribed sequence with moderate similarity to protein more 79.81(n)    BX706738.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2f1 ubiquitin-conjugating enzyme E2F (putative) 74.05(n)
    82.16(a)
      406606  NM_213314.1  NP_998479.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0121931 AgaP_AGAP012193 57.66(n)
    65.41(a)
      1280493  XM_320339.4  XP_320339.4 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-121 ubc-12 52.69(n)
    54.84(a)
      173072  NM_060623.4  NP_493024.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC126
    Enzyme that mediates the conjugation of Rub1p, a u...
    28(a)
    1 → many
    XII(744151-744851) YLR306W


    ENSEMBL Gene Tree for UBE2F (if available)
    TreeFam Gene Tree for UBE2F (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2F gene
    UBE2F-SCLY2  UBE2M2  
    17 SIMAP similar genes for UBE2F using alignment to 15 protein entries:     UBE2F_HUMAN (see all proteins):
    UBE2F-SCLY    UBE2N    UBE2M    HR6A    UBE2G1    UBE2A
    UBE2B    CDC34    UBE2K    UBE2D4    UBE2D1    UBE2S
    UBE2D2    UBE2L3    UBE2D3    UBE2E2    UBE2E3

    UBE2F for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for UBE2F
    PGOHUM00000248909 PGOHUM00000244849 PGOHUM00000247426 PGOHUM00000237587


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBE2F:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv876062CNV Loss21882294
    nsv214866CNV Loss16902084
    nsv508205CNV Loss20534489

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    3 diseases for UBE2F:    
    About MalaCards
    malaria    hiv-1    breast cancer


    UBE2F for disorders           About GeneDecksing


    Export disorders for UBE2F gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2F gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with UBE2F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2, 9 Huang D.T....Schulman B.A. (Mol. Cell 2009)
    2. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PubMed id 23201271)1, 2 Monda J.K....Schulman B.A. (Structure 2013)
    3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Vif hijacks CBF-I^ to degrade APOBEC3G and promote HIV-1 infection. (PubMed id 22190037)1 JAoger S....Krogan N.J. (Nature 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Inhibition of a NEDD8 Cascade Restores Restriction of HIV by APOBEC3G. (PubMed id 23300442)1 Stanley D.J....Gross J.D. (PLoS Pathog. 2012)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140739 HGNC: 12480 AceView: SCLYandNCE2 Ensembl:ENSG00000184182 euGenes: HUgn140739
    ECgene: UBE2F Kegg: 140739 H-InvDB: UBE2F

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2F gene:
    Search GeneIP for patents involving UBE2F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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