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Aliases for UBE2F Gene

Aliases for UBE2F Gene

  • Ubiquitin-Conjugating Enzyme E2F (Putative) 2 3
  • NEDD8 Carrier Protein UBE2F 3 4
  • NEDD8 Protein Ligase UBE2F 3 4
  • NEDD8-Conjugating Enzyme 2 3 4
  • NCE2 3 4
  • Ubiquitin-Conjugating Enzyme E2 F 4
  • NEDD8-Conjugating Enzyme UBE2F 3
  • NEDD8 Conjugating Enzyme 2
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for UBE2F Gene

Previous GeneCards Identifiers for UBE2F Gene

  • GC00U990541
  • GC02P238658
  • GC02P238540
  • GC02P238875
  • GC02P230667

Summaries for UBE2F Gene

GeneCards Summary for UBE2F Gene

UBE2F (Ubiquitin-Conjugating Enzyme E2F (Putative)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include NEDD8 transferase activity. An important paralog of this gene is UBE2M.

UniProtKB/Swiss-Prot for UBE2F Gene

  • Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2F Gene

Genomics for UBE2F Gene

Regulatory Elements for UBE2F Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2F Gene

Start:
237,966,827 bp from pter
End:
238,042,782 bp from pter
Size:
75,956 bases
Orientation:
Plus strand

Genomic View for UBE2F Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2F Gene

Proteins for UBE2F Gene

  • Protein details for UBE2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M7-UBE2F_HUMAN
    Recommended name:
    NEDD8-conjugating enzyme UBE2F
    Protein Accession:
    Q969M7
    Secondary Accessions:
    • A8K1Z8
    • B4DDT9
    • B4DFI1
    • B4DMK3
    • B4DZU2
    • B8ZZG2
    • C9J212
    • H9KVB9

    Protein attributes for UBE2F Gene

    Size:
    185 amino acids
    Molecular mass:
    21077 Da
    Quaternary structure:
    • Interacts with UBA3 and RBX2.

    Three dimensional structures from OCA and Proteopedia for UBE2F Gene

    Alternative splice isoforms for UBE2F Gene

neXtProt entry for UBE2F Gene

Proteomics data for UBE2F Gene at MOPED

Post-translational modifications for UBE2F Gene

  • The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains for UBE2F Gene

Gene Families for UBE2F Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2F Gene

Suggested Antigen Peptide Sequences for UBE2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969M7

UniProtKB/Swiss-Prot:

UBE2F_HUMAN :
  • Q969M7
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
genes like me logo Genes that share domains with UBE2F: view

Function for UBE2F Gene

Molecular function for UBE2F Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine
UniProtKB/Swiss-Prot Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

Enzyme Numbers (IUBMB) for UBE2F Gene

Gene Ontology (GO) - Molecular Function for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19250909
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
GO:0019788 NEDD8 transferase activity IDA 19250909
genes like me logo Genes that share ontologies with UBE2F: view

Phenotypes for UBE2F Gene

GenomeRNAi human phenotypes for UBE2F:
genes like me logo Genes that share phenotypes with UBE2F: view

Animal Model Products

CRISPR Products

miRNA for UBE2F Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2F

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2F Gene

Localization for UBE2F Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2F Gene COMPARTMENTS Subcellular localization image for UBE2F gene
Compartment Confidence
cytosol 2
extracellular 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBE2F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2F Gene

Pathways for UBE2F Gene

genes like me logo Genes that share pathways with UBE2F: view

UniProtKB/Swiss-Prot Q969M7-UBE2F_HUMAN

  • Pathway: Protein modification; protein neddylation

Gene Ontology (GO) - Biological Process for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0016567 NOT protein ubiquitination IBA --
GO:0045116 protein neddylation IEA --
genes like me logo Genes that share ontologies with UBE2F: view

Compounds for UBE2F Gene

(4) HMDB Compounds for UBE2F Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2F: view

Transcripts for UBE2F Gene

Unigene Clusters for UBE2F Gene

Ubiquitin-conjugating enzyme E2F (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2F

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2F Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:

Relevant External Links for UBE2F Gene

GeneLoc Exon Structure for
UBE2F
ECgene alternative splicing isoforms for
UBE2F

Expression for UBE2F Gene

mRNA expression in normal human tissues for UBE2F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2F Gene

SOURCE GeneReport for Unigene cluster for UBE2F Gene Hs.471785

mRNA Expression by UniProt/SwissProt for UBE2F Gene

Q969M7-UBE2F_HUMAN
Tissue specificity: Widely expressed (at protein level).
genes like me logo Genes that share expressions with UBE2F: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE2F Gene

Orthologs for UBE2F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 42 (a)
ManyToMany
UBE2F 35
  • 99.82 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia UBE2F 35
  • 90.63 (n)
  • 97.3 (a)
UBE2F 36
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 97 (a)
OneToMany
UBE2F 35
  • 92.25 (n)
  • 97.3 (a)
mouse
(Mus musculus)
Mammalia Gm5434 36
  • 89 (a)
ManyToMany
Ube2f 35
  • 92.25 (n)
  • 96.76 (a)
Ube2f 16
Ube2f 36
  • 97 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 93 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ube2f 35
  • 91.62 (n)
  • 95.71 (a)
chicken
(Gallus gallus)
Aves UBE2F 35
  • 85.95 (n)
  • 92.97 (a)
UBE2F 36
  • 83 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15431 35
ube2f 35
  • 78.56 (n)
  • 90.81 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2f 35
  • 74.05 (n)
  • 82.16 (a)
ube2f 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012193 35
  • 57.66 (n)
  • 65.41 (a)
worm
(Caenorhabditis elegans)
Secernentea ubc-12 35
  • 52.69 (n)
  • 54.84 (a)
ubc-12 36
  • 48 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC12 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3148 36
  • 48 (a)
OneToMany
Species with no ortholog for UBE2F:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2F Gene

ENSEMBL:
Gene Tree for UBE2F (if available)
TreeFam:
Gene Tree for UBE2F (if available)

Paralogs for UBE2F Gene

Paralogs for UBE2F Gene

Pseudogenes.org Pseudogenes for UBE2F Gene

genes like me logo Genes that share paralogs with UBE2F: view

Variants for UBE2F Gene

Structural Variations from Database of Genomic Variants (DGV) for UBE2F Gene

Variant ID Type Subtype PubMed ID
nsv508205 CNV Loss 20534489
nsv214866 CNV Loss 16902084
nsv876062 CNV Loss 21882294

Relevant External Links for UBE2F Gene

HapMap Linkage Disequilibrium report
UBE2F
Human Gene Mutation Database (HGMD)
UBE2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for UBE2F Gene

Disorders for UBE2F Gene

No disorders were found for UBE2F Gene.

No data available for UniProtKB/Swiss-Prot for UBE2F Gene

Publications for UBE2F Gene

  1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PMID: 19250909) Huang D.T. … Schulman B.A. (Mol. Cell 2009) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda J.K. … Schulman B.A. (Structure 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4

Products for UBE2F Gene

  • Addgene plasmids for UBE2F

Sources for UBE2F Gene

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