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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2F Gene

protein-coding   GIFtS: 56
GCID: GC02P238875

ubiquitin-conjugating enzyme E2F (putative)

  Search for UBE2F
in our new
 Human Malady Compendium 
Biological research products
for UBE2F
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2F (Putative)1 2     NEDD8-Conjugating Enzyme 22 3
NCE21 2 3     NEDD8-Conjugating Enzyme UBE2F2
Ubiquitin-Conjugating Enzyme E2 F2 3     EC 6.3.2.-3
NEDD8 Carrier Protein UBE2F2 3     EC 6.3.28
NEDD8 Protein Ligase UBE2F2 3     

External Ids:    HGNC: 124801   Entrez Gene: 1407392   Ensembl: ENSG000001841827   UniProtKB: Q969M73   

Export aliases for UBE2F gene to outside databases

Previous GC identifers: GC00U990541 GC02P238658 GC02P238540 GC02P230667


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment
to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the
RBX2-UBE2F complex neddylates specific target proteins, such as CUL5




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_005120.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2F gene promoter:
         TBP   AML1a   FOXD1   LUN-1   HNF-3beta   RORalpha2   GATA-6   TFIID   NF-Y   CBF(2)   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UBE2F

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2F


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

UBE2F Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2F gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P238875:  view genomic region     (about GC identifiers)

Start:
238,875,469 bp from pter      End:
238,951,236 bp from pter
Size:
75,768 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7 (See protein sequence)
Recommended Name: NEDD8-conjugating enzyme UBE2F  
Size: 185 amino acids; 21077 Da
Subunit: Interacts with UBA3 and RBX2
3 PDB 3D structures from and Proteopedia for UBE2F:
2EDI (3D)        3FN1 (3D)        4GBA (3D)    
Secondary accessions: A8K1Z8 B4DDT9 B4DFI1 B4DMK3 B4DZU2 B8ZZG2
Alternative splicing: 5 isoforms:  Q969M7-1   Q969M7-2   Q969M7-3   Q969M7-4   Q969M7-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2F: NX_Q969M7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q969M7

  • 4/6 DME Specific Peptides for UBE2F (Q969M7) (see all 6)
     GGKFQFE  EVAELEANLP  DPLNIEAAEHHL  AYNMVPPKVKCLT 

    UBE2F Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_542409.1  
    ENSEMBL proteins: 
     ENSP00000412965   ENSP00000409749   ENSP00000272930   ENSP00000410867   ENSP00000396003  
     ENSP00000390813   ENSP00000387299   ENSP00000389685   ENSP00000408823   ENSP00000396296  
     ENSP00000410345   ENSP00000396630   ENSP00000408676   ENSP00000393515   ENSP00000386680  
     ENSP00000387060   ENSP00000406113   ENSP00000414619   ENSP00000399183  
    Reactome Protein details: Q969M7
    Human Recombinant Protein Products: 
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    Uscn Proteins for UBE2F


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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    UBE2F for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q969M7

    ProtoNet protein and cluster: Q969M7

    1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Similarity: Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Function: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment
    to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the
    RBX2-UBE2F complex neddylates specific target proteins, such as CUL5
    Catalytic activity: ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine

    Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22

    miRNA
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    hsa-mir-335 (MIRT004083)

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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2F (see all 36):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-136 hsa-miR-300 hsa-miR-139-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidUBE2F 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2F

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19250909
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0019788NEDD8 ligase activity IDA19250909


    UBE2F for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UBE2F:
     Increased G1 DNA content 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation1.00
    Polyubiquitination of substrate0.75
    Class I MHC mediated antigen processing & presentation0.83
    Ubiquitin mediated proteolysis0.36
    2Immune System
    Immune System1.00
    Adaptive Immune System0.59
    3Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for UBE2F 
        Integrated Breast Cancer Pathway

    5        Reactome Pathways for UBE2F
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    1         Kegg Pathway  (Kegg details for UBE2F):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Pathway: Protein modification; protein neddylation


    UBE2F for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2F

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for UBE2F (Q969M73 ENSP000002729304) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF2B4Q9UI103, ENSP000003948694I2D: score=1 STRING: ENSP00000394869
    STAT1P422243, ENSP000003543944I2D: score=1 STRING: ENSP00000354394
    TYK2P295973, ENSP000002648184I2D: score=1 STRING: ENSP00000264818
    UBA3Q8TBC43, ENSP000003543404I2D: score=1 STRING: ENSP00000354340
    WDR77Q9BQA13, ENSP000002350904I2D: score=1 STRING: ENSP00000235090
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045116protein neddylation IEA--


    UBE2F for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2F

    4 HMDB Compounds for UBE2F    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Search CenterWatch for drugs/clinical trials and news about UBE2F 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2F gene: 
    NM_080678.2  

    Unigene Cluster for UBE2F:

    Ubiquitin-conjugating enzyme E2F (putative)
    Hs.471785  [show with all ESTs]
    Unigene Representative Sequence: NR_037904
    18/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000440223 ENST00000441728 ENST00000272930(uc002vxk.3 uc010zno.2 uc010znn.2 uc010znp.2)
    ENST00000433568 ENST00000448502 ENST00000416292 ENST00000409633 ENST00000455999
    ENST00000417231 ENST00000445676 ENST00000439338 ENST00000439780 ENST00000454786
    ENST00000433241 ENST00000409953 ENST00000409332 ENST00000434655 ENST00000434137


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    8/36 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2F (see all 36):
    hsa-miR-323-3p hsa-miR-549 hsa-miR-136 hsa-miR-300 hsa-miR-139-5p hsa-miR-128 hsa-let-7a-2* hsa-miR-632
    SwitchGear 3'UTR luciferase reporter plasmidUBE2F 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2F
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2F

    Additional cDNA sequence: 

    AF310723.1 AK290063.1 AK293334.1 AK294107.1 AK297502.1 AK303094.1 BC010549.1 BC039435.1 
    NR_037904.1 

    13 DOTS entries:

    DT.100825702  DT.100028467  DT.100825699  DT.95328589  DT.95194761  DT.121034236  DT.100825697  DT.100825706 
    DT.91712027  DT.95075373  DT.100825705  DT.100825711  DT.91712029 

    24/318 AceView cDNA sequences (see all 318):

    AI424010 NM_080678 AI791644 CR597540 BM665901 BE504322 CR620417 AA384235 
    AF310723 AI139363 BX117784 CR615230 AI142222 AW204367 CR610086 BM142247 
    BQ962765 BP431575 BU633895 BM793135 CR597637 CB123239 CA413036 AI688376 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2F    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                                 
    SP2:                    -                                                   
    SP3:                                                                        


    ECgene alternative splicing isoforms for UBE2F

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2F expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTGCTCATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See UBE2F Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2F

    SOURCE GeneReport for Unigene cluster: Hs.471785

    UniProtKB/Swiss-Prot: UBE2F_HUMAN, Q969M7
    Tissue specificity: Widely expressed (at protein level)

        SABiosciences Custom PCR Arrays for UBE2F
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2F

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBE2F gene from 6/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves UBE2F1 ubiquitin-conjugating enzyme E2F (putative) 85.95(n)
    92.97(a)
      424015  NM_001006512.1  NP_001006512.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2F6
    --
    91(a)
    1 → many
    1(117202683-117247626)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.154312 Transcribed sequence with moderate similarity to protein more 79.81(n)    BX706738.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2f1 ubiquitin-conjugating enzyme E2F (putative) 74.05(n)
    82.16(a)
      406606  NM_213314.1  NP_998479.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0121931 AGAP012193-PA 57.66(n)
    65.41(a)
      1280493  XM_320339.4  XP_320339.4 
    worm
    (Caenorhabditis elegans)
    Secernentea ubc-121 Protein UBC-12 52.69(n)
    54.84(a)
      173072  NM_060623.3  NP_493024.1 


    ENSEMBL Gene Tree for UBE2F (if available)
    TreeFam Gene Tree for UBE2F (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2F gene
    UBE2M2  ENSG000002589842  
    15 SIMAP similar genes for UBE2F using alignment to 17 protein entries:     UBE2F_HUMAN (see all proteins):
    UBE2N    UBE2M    HR6A    UBE2G1    UBE2A    UBE2B
    UBE2K    UBE2D4    UBE2D1    UBE2S    UBE2D2    UBE2D3
    UBE2E2    UBE2E3    UBE2L3

    UBE2F for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for UBE2F
    PGOHUM00000248909 PGOHUM00000244849 PGOHUM00000247426 PGOHUM00000237587


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1299 NCBI SNPs in UBE2F are shown (see all 1299    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs589649291,2
    C,--238873673(+) ACAGCG/AGTGGA 2 -- us2k13Minor allele frequency- A:0.31NA EA 242
    rs1477946411,2
    --238873731(+) AGTGAC/TGCTTA 2 -- us2k10--------
    rs1919032391,2
    --238873770(+) GGCTGC/TACCTT 2 -- us2k10--------
    rs766057861,2
    F,--238873909(+) GGTGAC/TGCTGG 2 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1841949761,2
    --238873996(+) GCAGGA/GCTCCA 2 -- us2k10--------
    rs1411856231,2
    --238874004(+) CCAAGA/GAAGAC 2 -- us2k10--------
    rs1451319811,2
    --238874065(+) CAGAAG/TTTGGT 2 -- us2k10--------
    rs1874957241,2
    --238874078(+) CTTAGC/TTTAGG 2 -- us2k10--------
    rs1448595221,2
    C,--238874130(+) TCCCA-/AACAC 
     AAGAAAT
    AACAC
    2 -- us2k10--------
    rs790192121,2
    F,--238874158(+) TGTTCT/CTTCTT 2 -- us2k11Minor allele frequency- C:0.05WA 118

    HapMap Linkage Disequilibrium report for UBE2F (238875469 - 238951236 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for UBE2F
         1 CNV: 6037

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2F gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with UBE2F)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PubMed id 19250909)1, 2, 9 Huang D.T....Schulman B.A. (2009)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Vif hijacks CBF-b to degrade APOBEC3G and promote HIV- 1 infection. (PubMed id 22190037)1 Jager S....Krogan N.J. (2012)
    7. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 140739 HGNC: 12480 AceView: SCLYandNCE2 Ensembl:ENSG00000184182 euGenes: HUgn140739
    ECgene: UBE2F Kegg: 140739 H-InvDB: UBE2F

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2F Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2F gene:
    Search GeneIP for patents involving UBE2F

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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