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Aliases for UBE2F Gene

Aliases for UBE2F Gene

  • Ubiquitin Conjugating Enzyme E2 F (Putative) 2 3 5
  • Ubiquitin-Conjugating Enzyme E2F (Putative) 2 3
  • NEDD8 Carrier Protein UBE2F 3 4
  • NEDD8 Protein Ligase UBE2F 3 4
  • NEDD8-Conjugating Enzyme 2 3 4
  • NCE2 3 4
  • Ubiquitin-Conjugating Enzyme E2 F 4
  • NEDD8-Conjugating Enzyme UBE2F 3
  • NEDD8 Conjugating Enzyme 2
  • EC 6.3.2.- 4
  • EC 6.3.2 61

External Ids for UBE2F Gene

Previous GeneCards Identifiers for UBE2F Gene

  • GC00U990541
  • GC02P238658
  • GC02P238540
  • GC02P238875
  • GC02P230667
  • GC02P237967
  • GC02P237969
  • GC02P237970
  • GC02P237971

Summaries for UBE2F Gene

GeneCards Summary for UBE2F Gene

UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway and Immune System. GO annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F-SCLY.

UniProtKB/Swiss-Prot for UBE2F Gene

  • Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2F Gene

Genomics for UBE2F Gene

Regulatory Elements for UBE2F Gene

Enhancers for UBE2F Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F237963 1.2 FANTOM5 Ensembl ENCODE 24.9 -0.1 -52 6.2 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ILKAP UBE2F SCLY RAMP1 ESPNL KLHL30 ASB1 HES6 LRRFIP1 GC02P237964
GH02F237939 0.9 Ensembl ENCODE 21.6 -24.8 -24807 4.6 CBX3 TBL1XR1 NFRKB PTRF SIN3A ZNF335 CBX5 ZBTB11 NCOA1 CEBPB UBE2F ESPNL RAMP1 ILKAP SCLY LOC105373960 PIR54851 GC02P237963 GC02P237973 GC02P237974
GH02F237997 1.3 Ensembl ENCODE 21 +31.7 31720 1.8 SOX13 PKNOX1 MXI1 TBL1XR1 ZNF384 CDC5L EBF1 YBX1 PLRG1 RFX5 UBE2F RNU6-1333P SCLY ESPNL RAMP1 ILKAP UBE2F-SCLY
GH02F237955 0.2 Ensembl 19 -10.6 -10563 1.2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 GLIS2 FOS SP5 UBE2F ESPNL SCLY GC02P237963 GC02P237973 GC02P237974 PIR54851 LOC105373960
GH02F238097 1.2 Ensembl ENCODE 17.6 +133.0 132981 5.1 PKNOX1 ESRRA DEAF1 MAX RAD21 ZFHX2 ZNF316 CTBP1 GATA3 GLIS2 ESPNL UBE2F KLHL30 SCLY HES6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UBE2F on UCSC Golden Path with GeneCards custom track

Promoters for UBE2F Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000610389 274 2200 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 FOS
ENSR00001834238 1973 401 CTCF HDAC1 TFAP4 MXI1 TBL1XR1 SAP130 WRNIP1 SIN3A MAX RAD21

Genomic Location for UBE2F Gene

Chromosome:
2
Start:
237,966,827 bp from pter
End:
238,042,782 bp from pter
Size:
75,956 bases
Orientation:
Plus strand

Genomic View for UBE2F Gene

Genes around UBE2F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2F Gene

Proteins for UBE2F Gene

  • Protein details for UBE2F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969M7-UBE2F_HUMAN
    Recommended name:
    NEDD8-conjugating enzyme UBE2F
    Protein Accession:
    Q969M7
    Secondary Accessions:
    • A8K1Z8
    • B4DDT9
    • B4DFI1
    • B4DMK3
    • B4DZU2
    • B8ZZG2
    • C9J212
    • H9KVB9

    Protein attributes for UBE2F Gene

    Size:
    185 amino acids
    Molecular mass:
    21077 Da
    Quaternary structure:
    • Interacts with UBA3 and RBX2.

    Three dimensional structures from OCA and Proteopedia for UBE2F Gene

    Alternative splice isoforms for UBE2F Gene

neXtProt entry for UBE2F Gene

Selected DME Specific Peptides for UBE2F Gene

Q969M7:
  • GGKFQFE
  • IWHPNITETGEICLSLLREHS
  • DGTGWAPTRTLKDVVWGLNSLFTDLLNF
  • AYNMVPPKVKCLT
  • EVAELEANLP
  • DPLNIEAAEHHL

Post-translational modifications for UBE2F Gene

  • The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UBE2F Gene

Gene Families for UBE2F Gene

Suggested Antigen Peptide Sequences for UBE2F Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969M7

UniProtKB/Swiss-Prot:

UBE2F_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily.
genes like me logo Genes that share domains with UBE2F: view

Function for UBE2F Gene

Molecular function for UBE2F Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + NEDD8 + protein lysine = AMP + diphosphate + protein N-NEDD8yllysine.
UniProtKB/Swiss-Prot Function:
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

Enzyme Numbers (IUBMB) for UBE2F Gene

Gene Ontology (GO) - Molecular Function for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19250909
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0019788 NEDD8 transferase activity IDA 19250909
GO:0031625 ubiquitin protein ligase binding IBA --
genes like me logo Genes that share ontologies with UBE2F: view
genes like me logo Genes that share phenotypes with UBE2F: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2F

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2F

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2F Gene

Localization for UBE2F Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2F Gene COMPARTMENTS Subcellular localization image for UBE2F gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBE2F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2F Gene

Pathways & Interactions for UBE2F Gene

genes like me logo Genes that share pathways with UBE2F: view

UniProtKB/Swiss-Prot Q969M7-UBE2F_HUMAN

  • Pathway: Protein modification; protein neddylation.

Gene Ontology (GO) - Biological Process for UBE2F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006301 postreplication repair IBA --
GO:0045116 protein neddylation IEA --
GO:0070534 protein K63-linked ubiquitination IBA --
genes like me logo Genes that share ontologies with UBE2F: view

No data available for SIGNOR curated interactions for UBE2F Gene

Drugs & Compounds for UBE2F Gene

(3) Drugs for UBE2F Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2F Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with UBE2F: view

Transcripts for UBE2F Gene

Unigene Clusters for UBE2F Gene

Ubiquitin-conjugating enzyme E2F (putative):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBE2F

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2F Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2: -
SP3:

Relevant External Links for UBE2F Gene

GeneLoc Exon Structure for
UBE2F
ECgene alternative splicing isoforms for
UBE2F

Expression for UBE2F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBE2F Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2F Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.9) and Platelet (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2F Gene



Protein tissue co-expression partners for UBE2F Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2F Gene:

UBE2F

SOURCE GeneReport for Unigene cluster for UBE2F Gene:

Hs.471785

mRNA Expression by UniProt/SwissProt for UBE2F Gene:

Q969M7-UBE2F_HUMAN
Tissue specificity: Widely expressed (at protein level).
genes like me logo Genes that share expression patterns with UBE2F: view

Primer Products

No data available for mRNA differential expression in normal tissues for UBE2F Gene

Orthologs for UBE2F Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for UBE2F Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2F 34
  • 99.82 (n)
-- 35
  • 42 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 97 (a)
OneToMany
UBE2F 34
  • 92.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ube2f 34 16 35
  • 92.25 (n)
Gm5434 35
  • 89 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ube2f 34
  • 91.62 (n)
cow
(Bos Taurus)
Mammalia UBE2F 34 35
  • 90.63 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves UBE2F 34 35
  • 85.95 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 91 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2f 34
  • 78.56 (n)
Str.15431 34
zebrafish
(Danio rerio)
Actinopterygii ube2f 34 35
  • 74.05 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012193 34
  • 57.66 (n)
worm
(Caenorhabditis elegans)
Secernentea ubc-12 34 35
  • 52.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC12 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3148 35
  • 48 (a)
OneToMany
Species where no ortholog for UBE2F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2F Gene

ENSEMBL:
Gene Tree for UBE2F (if available)
TreeFam:
Gene Tree for UBE2F (if available)

Paralogs for UBE2F Gene

Variants for UBE2F Gene

Sequence variations from dbSNP and Humsavar for UBE2F Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10048643 -- 237,989,292(+) GGTGG(A/G)TTGCA intron-variant
rs10048814 -- 237,989,113(+) CTTCC(C/T)TTAAA intron-variant
rs10166061 -- 237,997,869(+) AAAAG(C/T)GTCCA intron-variant
rs10167355 -- 238,017,965(+) TTGAC(G/T)TTTTA intron-variant
rs10172855 -- 238,017,412(+) AACTT(A/G)CAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2F Gene

Variant ID Type Subtype PubMed ID
dgv4193n100 CNV gain 25217958
nsv1000252 CNV loss 25217958
nsv1011723 CNV gain 25217958
nsv214866 CNV deletion 16902084
nsv508205 CNV deletion 20534489
nsv979190 CNV duplication 23825009

Variation tolerance for UBE2F Gene

Residual Variation Intolerance Score: 37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2F Gene

Human Gene Mutation Database (HGMD)
UBE2F
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2F

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2F Gene

Disorders for UBE2F Gene

Relevant External Links for UBE2F

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2F

No disorders were found for UBE2F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2F Gene

Publications for UBE2F Gene

  1. E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification. (PMID: 19250909) Huang D.T. … Schulman B.A. (Mol. Cell 2009) 2 3 4 22 64
  2. Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes. (PMID: 23201271) Monda J.K. … Schulman B.A. (Structure 2013) 2 3 4 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Both Rbx1 and Rbx2 exhibit a functional role in the HIV-1 Vif-Cullin5 E3 ligase complex inA vitro. (PMID: 25912140) Wang X. … Yu X. (Biochem. Biophys. Res. Commun. 2015) 3 64

Products for UBE2F Gene

Sources for UBE2F Gene

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