Aliases for UBE2F Gene
External Ids for UBE2F Gene
Previous GeneCards Identifiers for UBE2F Gene
GeneCards Summary for UBE2F Gene
UBE2F (Ubiquitin Conjugating Enzyme E2 F (Putative)) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is UBE2F-SCLY.
UniProtKB/Swiss-Prot for UBE2F Gene
Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.