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Aliases for UBE2E3 Gene

Aliases for UBE2E3 Gene

  • Ubiquitin-Conjugating Enzyme E2E 3 2 3
  • UBCH9 3 4 6
  • Ubiquitin-Conjugating Enzyme E2E 3 (Homologous To Yeast UBC4/5) 2 3
  • Ubiquitin-Conjugating Enzyme E2E 3 (UBC4/5 Homolog, Yeast) 2 3
  • Ubiquitin-Conjugating Enzyme E2-23 KDa 3 4
  • Ubiquitin Carrier Protein E3 3 4
  • Ubiquitin-Protein Ligase E3 3 4
  • EC 6.3.2.19 4 63
  • Ubiquitin-Conjugating Enzyme E2 E3 3
  • UbcM2 3
  • UBCE4 4

External Ids for UBE2E3 Gene

Summaries for UBE2E3 Gene

Entrez Gene Summary for UBE2E3 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for UBE2E3 Gene

UBE2E3 (Ubiquitin-Conjugating Enzyme E2E 3) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Remodeling of Adherens Junctions. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2E3 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.

Gene Wiki entry for UBE2E3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2E3 Gene

Genomics for UBE2E3 Gene

Genomic Location for UBE2E3 Gene

Start:
180,967,248 bp from pter
End:
181,076,585 bp from pter
Size:
109,338 bases
Orientation:
Plus strand

Genomic View for UBE2E3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2E3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2E3 Gene

Regulatory Elements for UBE2E3 Gene

Proteins for UBE2E3 Gene

  • Protein details for UBE2E3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969T4-UB2E3_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 E3
    Protein Accession:
    Q969T4
    Secondary Accessions:
    • B2RAD6
    • D3DPG3
    • Q5U0R7
    • Q7Z4W4

    Protein attributes for UBE2E3 Gene

    Size:
    207 amino acids
    Molecular mass:
    22913 Da
    Quaternary structure:
    • The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the nucleus (By similarity). Interacts with NEDD4L.

neXtProt entry for UBE2E3 Gene

Proteomics data for UBE2E3 Gene at MOPED

Post-translational modifications for UBE2E3 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys150

Domains for UBE2E3 Gene

Gene Families for UBE2E3 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2E3 Gene

Suggested Antigen Peptide Sequences for UBE2E3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969T4

UniProtKB/Swiss-Prot:

UB2E3_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • Q969T4
genes like me logo Genes that share domains with UBE2E3: view

Function for UBE2E3 Gene

Molecular function for UBE2E3 Gene

GENATLAS Biochemistry: ubiquitin conjugating enzyme E2E3,homologous to yeast UBC4/5,expressed in skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.

Enzyme Numbers (IUBMB) for UBE2E3 Gene

Gene Ontology (GO) - Molecular Function for UBE2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 14667819
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2E3: view

miRNA for UBE2E3 Gene

miRTarBase miRNAs that target UBE2E3

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2E3 Gene

Localization for UBE2E3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2E3 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2E3 Gene COMPARTMENTS Subcellular localization image for UBE2E3 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for UBE2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBE2E3: view

Pathways for UBE2E3 Gene

genes like me logo Genes that share pathways with UBE2E3: view

UniProtKB/Swiss-Prot Q969T4-UB2E3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0040008 regulation of growth IEA --
GO:0070534 protein K63-linked ubiquitination IDA 20061386
GO:0070936 protein K48-linked ubiquitination IDA 20061386
GO:0070979 protein K11-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2E3: view

Compounds for UBE2E3 Gene

(5) HMDB Compounds for UBE2E3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
Sodium
  • Sodium
7440-23-5

(6) Novoseek inferred chemical compound relationships for UBE2E3 Gene

Compound -log(P) Hits PubMed IDs
rotenone 56.5 1
cysteine 32.7 2
colchicine 27.8 1
gtp 2.45 1
steroid 0 1
genes like me logo Genes that share compounds with UBE2E3: view

Transcripts for UBE2E3 Gene

Unigene Clusters for UBE2E3 Gene

Ubiquitin-conjugating enzyme E2E 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2E3 Gene

No ASD Table

Relevant External Links for UBE2E3 Gene

GeneLoc Exon Structure for
UBE2E3
ECgene alternative splicing isoforms for
UBE2E3

Expression for UBE2E3 Gene

mRNA expression in normal human tissues for UBE2E3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UBE2E3 Gene

SOURCE GeneReport for Unigene cluster for UBE2E3 Gene Hs.470804

mRNA Expression by UniProt/SwissProt for UBE2E3 Gene

Q969T4-UB2E3_HUMAN
Tissue specificity: Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.
genes like me logo Genes that share expressions with UBE2E3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBE2E3 Gene

Orthologs for UBE2E3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2E3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2E3 35
  • 100 (n)
  • 100 (a)
UBE2E3 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2E3 35
  • 96.46 (n)
  • 100 (a)
UBE2E3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2E3 35
  • 96.62 (n)
  • 100 (a)
UBE2E3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2e3 35
  • 95.49 (n)
  • 100 (a)
Ube2e3 16
Ube2e3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2E3 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2E3 36
  • 79 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2e3 35
  • 95.81 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves UBE2E3 35
  • 90.82 (n)
  • 99.52 (a)
UBE2E3 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2E3 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7787 35
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2e3 35
  • 85.51 (n)
  • 99.03 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2e3 35
  • 80.35 (n)
  • 95.65 (a)
ube2e3 36
  • 95 (a)
OneToOne
zgc55923 35
fruit fly
(Drosophila melanogaster)
Insecta CG2574 36
  • 38 (a)
ManyToMany
CG5440 36
  • 65 (a)
ManyToMany
UbcD2 36
  • 66 (a)
ManyToMany
CG10862 37
  • 52 (a)
UbcD2 37
  • 86 (a)
CG2574 37
  • 50 (a)
CG5440 37
  • 71 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FUS9 35
  • 61.04 (n)
  • 58.78 (a)
rice
(Oryza sativa)
Liliopsida Os07g0577400 35
  • 57.89 (n)
  • 60.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6406 36
  • 71 (a)
OneToMany
Species with no ortholog for UBE2E3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2E3 Gene

ENSEMBL:
Gene Tree for UBE2E3 (if available)
TreeFam:
Gene Tree for UBE2E3 (if available)

Paralogs for UBE2E3 Gene

Paralogs for UBE2E3 Gene

genes like me logo Genes that share paralogs with UBE2E3: view

Variants for UBE2E3 Gene

Sequence variations from dbSNP and Humsavar for UBE2E3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs873255 -- 181,059,873(-) TGTAC(G/T)GTGAG intron-variant
rs873256 -- 181,059,624(-) ATTTC(A/T)AAGAG intron-variant
rs908734 -- 181,059,947(-) ACTAA(C/T)TGGAT intron-variant
rs908735 -- 181,059,158(-) ACTGT(A/G)TATCT intron-variant
rs908736 -- 181,059,046(-) AAATC(A/G)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2E3 Gene

Variant ID Type Subtype PubMed ID
nsv875476 CNV Loss 21882294
esv2721202 CNV Deletion 23290073
esv270802 CNV Insertion 20981092
dgv17e194 CNV Deletion 18987734
esv2721203 CNV Deletion 23290073
esv3605 CNV Deletion 18987735
esv9135 CNV Loss 19470904

Relevant External Links for UBE2E3 Gene

HapMap Linkage Disequilibrium report
UBE2E3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2E3 Gene

Disorders for UBE2E3 Gene

(4) Novoseek inferred disease relationships for UBE2E3 Gene

Disease -log(P) Hits PubMed IDs
parkinsonism juvenile autosomal recessive 89.6 4
parkinson disease 57.9 4
parkinsonism 48 3
tumors 0 2

Relevant External Links for UBE2E3

Genetic Association Database (GAD)
UBE2E3
Human Genome Epidemiology (HuGE) Navigator
UBE2E3
genes like me logo Genes that share disorders with UBE2E3: view

No data available for UniProtKB/Swiss-Prot for UBE2E3 Gene

Publications for UBE2E3 Gene

  1. cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin- conjugating enzyme. (PMID: 10343118) Ito K. … Okano Y. (Cytogenet. Cell Genet. 1999) 2 3 4 23
  2. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PMID: 15545318) Plafker S.M. … Macara I.G. (J. Cell Biol. 2004) 3 4 23
  3. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PMID: 11322894) Ito K. … Okano Y. (Eur. J. Biochem. 2001) 3 23
  4. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3 23
  5. The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells. (PMID: 18614808) Plafker K.S. … Plafker S.M. (Invest. Ophthalmol. Vis. Sci. 2008) 3 23

Products for UBE2E3 Gene

Sources for UBE2E3 Gene

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