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UBE2E3 Gene

protein-coding   GIFtS: 65
GCID: GC02P181809

Ubiquitin-Conjugating Enzyme E2E 3

(Previous names: ubiquitin-conjugating enzyme E2E 3 (homologous to yeast...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ubiquitin-Conjugating Enzyme E2E 31 2     Ubiquitin-Protein Ligase E32 3
UBCH92 3 5     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme E2E 3 (Homologous To Yeast UBC4/5)1 2     UbcM22
Ubiquitin-Conjugating Enzyme E2E 3 (UBC4/5 Homolog, Yeast)1 2     Ubiquitin-Conjugating Enzyme E2 E32
Ubiquitin Carrier Protein E32 3     UBCE43
Ubiquitin-Conjugating Enzyme E2-23 KDa2 3     UbcH93

External Ids:    HGNC: 124791   Entrez Gene: 104772   Ensembl: ENSG000001700357   OMIM: 6041515   UniProtKB: Q969T43   
ORGUL members:         

Export aliases for UBE2E3 gene to outside databases

Previous GC identifers: GC02P180033 GC02P180529 GC02P182047 GC02P181670 GC02P181553 GC02P173700


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2E3 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100%
sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in
eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this
gene. (provided by RefSeq, Jun 2013)

GeneCards Summary for UBE2E3 Gene:
UBE2E3 (ubiquitin-conjugating enzyme E2E 3) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation
of transepithelial sodium transport in renal cells. May be involved in cell growth arrest

Gene Wiki entry for UBE2E3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2E3 gene promoter:
         MEF-2A   TBP   AREB6   FAC1   aMEF-2   Evi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for UBE2E3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2E3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q31.3   HGNC cytogenetic band: 2q31.3

UBE2E3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2E3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P181809:  view genomic region     (about GC identifiers)

Start:
181,831,975 bp from pter      End:
181,941,312 bp from pter
Size:
109,338 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 E3  
Size: 207 amino acids; 22913 Da
Subunit: The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the
nucleus (By similarity). Interacts with NEDD4L
Secondary accessions: B2RAD6 D3DPG3 Q5U0R7 Q7Z4W4

Explore the universe of human proteins at neXtProt for UBE2E3: NX_Q969T4

Explore proteomics data for UBE2E3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys150
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2E3 (Q969T4) (see all 7)
     YPFKPPK  EHDRIAR  ICLDILK  TNRAEHDR 


    See UBE2E3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265483.1  NP_001265484.1  NP_006348.1  NP_872619.1  

    ENSEMBL proteins: 
     ENSP00000473525   ENSP00000473639   ENSP00000473345   ENSP00000473591   ENSP00000386788  
     ENSP00000473264   ENSP00000473521   ENSP00000473623   ENSP00000473642   ENSP00000376215  
    Reactome Protein details: Q969T4

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry Q969T4

    ProtoNet protein and cluster: Q969T4

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2E3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2E3_HUMAN, Q969T4
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation
    of transepithelial sodium transport in renal cells. May be involved in cell growth arrest
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2E3:
    ubiquitin conjugating enzyme E2E3,homologous to yeast UBC4/5,expressed in skeletal muscle

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with UBE2E3           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Ube2e3 (no phenotypes)

    Find genes that share phenotypes with UBE2E3           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2E3
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    Selected qRT-PCR Assays for microRNAs that regulate UBE2E3 (see all 34):
    hsa-miR-142-5p hsa-miR-485-3p hsa-miR-139-5p hsa-miR-16-1* hsa-miR-374a hsa-miR-3921 hsa-miR-548m hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidUBE2E3 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UB2E3_HUMAN, Q969T4: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent
    manner
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with UBE2E3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2E3 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Proteolysis Putative SUMO 1 pathway
    Proteolysis Putative SUMO 1 pathway0.33
    3Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    4Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions
    5Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum


    Find genes that share SuperPaths with UBE2E3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2E3
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for UBE2E3
        Proteolysis Putative SUMO-1 pathway


    1 Reactome Pathway for UBE2E3
        Antigen processing: Ubiquitination & Proteasome degradation


    2 Kegg Pathways  (Kegg details for UBE2E3):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2E3: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2E3

    Selected Interacting proteins for UBE2E3 (Q969T42, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 88)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183574Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    ENSG00000223767Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    ENSG00000225452Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    ENSG00000227277Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    ENSG00000228405Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0040008regulation of growth IEA--
    GO:0070534protein K63-linked ubiquitination IDA--
    GO:0070936protein K48-linked ubiquitination IDA--
    GO:0070979protein K11-linked ubiquitination IDA--

    Find genes that share ontologies with UBE2E3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2E3 (UB2E3)

    5 HMDB Compounds for UBE2E3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    SodiumSodium (see all 2)7440-23-5--

    6 Novoseek inferred chemical compound relationships for UBE2E3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rotenone 56.5 1 17587308 (1)
    cysteine 32.7 2 10343118 (1), 15545318 (1)
    colchicine 27.8 1 17587308 (1)
    gtp 2.45 1 11032817 (1)
    steroid 0 1 15691896 (1)
    serine 0 1 10343118 (1)



    Find genes that share compounds with UBE2E3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2E3 gene (4 alternative transcripts): 
    NM_001278554.1  NM_001278555.1  NM_006357.3  NM_182678.2  

    Unigene Cluster for UBE2E3:

    Ubiquitin-conjugating enzyme E2E 3
    Hs.470804  [show with all ESTs]
    Unigene Representative Sequence: BM912832
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602303 ENST00000602959 ENST00000602479 ENST00000602291 ENST00000410062(uc002unr.1)
    ENST00000602475 ENST00000602499 ENST00000602710 ENST00000602762 ENST00000602632
    ENST00000602888 ENST00000602837 ENST00000602970 ENST00000392415(uc002unq.1 uc010fri.1)

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    hsa-miR-142-5p hsa-miR-485-3p hsa-miR-139-5p hsa-miR-16-1* hsa-miR-374a hsa-miR-3921 hsa-miR-548m hsa-miR-374c
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    Additional mRNA sequence: 

    AB017644.1 AF085362.1 AK314145.1 BC003554.1 BC003687.1 BC092407.1 BT019345.1 

    20 DOTS entries:

    DT.218837  DT.95227459  DT.99940731  DT.99983990  DT.92451651  DT.100826030  DT.120950576  DT.95227487 
    DT.100031738  DT.102831523  DT.120950601  DT.100800490  DT.100826023  DT.95227461  DT.100717255  DT.40189481 
    DT.91824456  DT.91926280  DT.92451650  DT.95098679 

    Selected AceView cDNA sequences (see all 393):

    AI150883 AI571353 CB215063 C20582 AI084547 AU098426 AA448500 BM709745 
    BQ070497 AI038444 BE562759 CB135485 BE222487 AA864850 BQ441123 AI872803 
    BU630586 AA864949 BM927792 CR607535 BM707875 BG187677 AA731196 AU102616 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2E3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCTGAAGG
    UBE2E3 Expression
    About this image

    UBE2E3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2E3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.470804

    UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
    Tissue specificity: Ubiquitously expressed at low levels. Highly expressed in skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2E3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2E3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2E3 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2e31 , 5 ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog more5
    ubiquitin-conjugating enzyme E2E 31
    95.49(n)1
    100(a)1
      2 (47.15 cM)5
    221931  NM_009454.21  NP_033480.11 
     788681245 
    chicken
    (Gallus gallus)
    Aves UBE2E31 ubiquitin-conjugating enzyme E2E 3 90.82(n)
    99.52(a)
      424122  NM_001195424.1  NP_001182353.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2E36
    ubiquitin-conjugating enzyme E2E 3
    92(a)
    1 ↔ 1
    GL343455.1(131378-414149)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77872 Xenopus laevis transcribed sequence with strong similarity more 86.27(n)    CD253593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559232 similar to ubiquitin-conjugating enzyme E2E 3, UBC4/5 more 83.53(n)   393895  BC042331.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta UbcD23 ubiquitin cycle ubiquitin conjugating
    enzyme
    86(a)
    (best of 4)
      2 32A5   --
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons FUS91 FUS9 61.04(n)
    58.78(a)
      820557  NM_112201.4  NP_566459.2 
    rice
    (Oryza sativa)
    Liliopsida Os07g05774001 Os07g0577400 57.89(n)
    60.53(a)
      4343707  NM_001066623.1  NP_001060088.1 


    ENSEMBL Gene Tree for UBE2E3 (if available)
    TreeFam Gene Tree for UBE2E3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2E3 gene
    UBE2D32  UBE2L62  UBE2D12  UBE2D42  UBE2E22  UBE2E12  UBE2D22  UBE2L32  
    Selected SIMAP similar genes for UBE2E3 using alignment to 5 protein entries:     UB2E3_HUMAN (see all proteins) (see all similar genes):
    UBE2E1    UBE2D1    UBE2D3    UBE2D2    UBE2D4    UBE2E2
    HR6A    UBE2A    UBE2B    UBE2I    UBE2DNL    UBE2L3
    UBE2N    UBE2M    UBE2S    UBE2T    UBE2W    UBE2K

    Find genes that share paralogs with UBE2E3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2E3 (see all 1959)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164063721,2
    C--173698358(+) AATTGA/CTGATT 1 -- us2k10--------
    rs1483593161,2
    C--173698391(+) CTTTAC/TTTCTT 1 -- us2k10--------
    rs1929861831,2
    --173698427(+) GCTACA/GTTTCT 1 -- us2k10--------
    rs774270381,2
    C,F--173698457(+) TGAGCT/CTGGTT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs2020916141,2
    --173698487(+) CACTC-/CAGTTTC 1 -- us2k10--------
    rs1853225451,2
    --173698586(+) CATGGA/CATTTT 1 -- us2k10--------
    rs752490831,2
    --173698669(+) CCTGAC/GGTCAT 1 -- us2k10--------
    rs1141333661,2
    F--173698691(+) AGAATG/AAGGAT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1508969731,2
    --173698697(+) AGGATC/TAGAAT 1 -- us2k10--------
    rs1898064911,2
    --173698777(+) TTCTCC/GCCTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2E3 (181831975 - 181941312 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for UBE2E3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2721202CNV Deletion23290073
    esv3605CNV Deletion18987735
    dgv17e194CNV Deletion18987734
    esv2721203CNV Deletion23290073
    esv270802CNV Insertion20981092
    esv9135CNV Loss19470904
    nsv875476CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2E3
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2E3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604151    OMIM disorders: --


    Find genes that share disorders with UBE2E3           About GenesLikeMe

    4 Novoseek inferred disease relationships for UBE2E3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinsonism juvenile autosomal recessive 89.6 4 12975291 (1), 16375772 (1), 16096643 (1), 19705877 (1)
    parkinson disease 57.9 4 12928331 (1), 19036992 (1), 16714300 (1), 15492001 (1)
    parkinsonism 48 3 16375772 (1), 12783850 (1), 14519684 (1)
    tumors 0 2 14507994 (1), 10421634 (1)

    Genetic Association Database (GAD): UBE2E3
    Human Genome Epidemiology (HuGE) Navigator: UBE2E3 (1 document)

    Export disorders for UBE2E3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2E3 gene, integrated from 10 sources (see all 156):
    (articles sorted by number of sources associating them with UBE2E3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin- conjugating enzyme. (PubMed id 10343118)1, 2, 3, 9 Ito K.... Okano Y. (Cytogenet. Cell Genet. 1999)
    2. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PubMed id 15545318)1, 2, 9 Plafker S.M.... Macara I.G. (J. Cell Biol. 2004)
    3. Multiple common variants for celiac disease influencing immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (Nat. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells. (PubMed id 18614808)1, 9 Plafker K.S....Plafker S.M. (amp 2008)
    8. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. (PubMed id 10187858)1, 9 Desterro J.M.P.... Hay R.T. (J. Biol. Chem. 1999)
    9. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PubMed id 11322894)1, 9 Ito K.... Okano Y. (Eur. J. Biochem. 2001)
    10. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1, 9 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10477 HGNC: 12479 AceView: UBE2E3 Ensembl:ENSG00000170035 euGenes: HUgn10477
    ECgene: UBE2E3 Kegg: 10477 H-InvDB: UBE2E3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2E3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2E3 gene:
    Search GeneIP for patents involving UBE2E3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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