Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2E3 Gene

protein-coding   GIFtS: 63
GCID: GC02P181809

Ubiquitin-Conjugating Enzyme E2E 3

(Previous names: ubiquitin-conjugating enzyme E2E 3 (homologous to yeast...)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2E 31 2     Ubiquitin-Protein Ligase E32 3
UBCH92 3 5     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme E2E 3 (Homologous To Yeast UBC4/5)1 2     UbcM22
Ubiquitin-Conjugating Enzyme E2E 3 (UBC4/5 Homolog, Yeast)1 2     Ubiquitin-Conjugating Enzyme E2 E32
Ubiquitin Carrier Protein E32 3     UBCE43
Ubiquitin-Conjugating Enzyme E2-23 KDa2 3     UbcH93

External Ids:    HGNC: 124791   Entrez Gene: 104772   Ensembl: ENSG000001700357   OMIM: 6041515   UniProtKB: Q969T43   

Export aliases for UBE2E3 gene to outside databases

Previous GC identifers: GC02P180033 GC02P180529 GC02P182047 GC02P181670 GC02P181553 GC02P173700


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2E3 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100%
sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in
eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this
gene. (provided by RefSeq, Jun 2013)

GeneCards Summary for UBE2E3 Gene: 
UBE2E3 (ubiquitin-conjugating enzyme E2E 3) is a protein-coding gene. Diseases associated with UBE2E3 include liddle syndrome, and triple-a syndrome, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation
of transepithelial sodium transport in renal cells. May be involved in cell growth arrest

Gene Wiki entry for UBE2E3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2E3 gene promoter:
         MEF-2A   TBP   AREB6   FAC1   aMEF-2   Evi-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UBE2E3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2E3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q32.1   Ensembl cytogenetic band:  2q31.3   HGNC cytogenetic band: 2q31.3

UBE2E3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2E3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P181809:  view genomic region     (about GC identifiers)

Start:
181,831,975 bp from pter      End:
181,941,312 bp from pter
Size:
109,338 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 E3  
Size: 207 amino acids; 22913 Da
Subunit: The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the
nucleus (By similarity). Interacts with NEDD4L
Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent
manner
Secondary accessions: B2RAD6 D3DPG3 Q5U0R7 Q7Z4W4

Explore the universe of human proteins at neXtProt for UBE2E3: NX_Q969T4

Explore proteomics data for UBE2E3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969T4

  • 4/7 DME Specific Peptides for UBE2E3 (Q969T4) (see all 7)
     YPFKPPK  EHDRIAR  ICLDILK  TNRAEHDR 

    UBE2E3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2E3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001265483.1  NP_001265484.1  NP_006348.1  NP_872619.1  

    ENSEMBL proteins: 
     ENSP00000473525   ENSP00000473639   ENSP00000473345   ENSP00000473591   ENSP00000386788  
     ENSP00000473264   ENSP00000473521   ENSP00000473623   ENSP00000473642   ENSP00000376215  
    Reactome Protein details: Q969T4
    Human Recombinant Protein Products for UBE2E3: 
    EMD Millipore Purified and/or Recombinant UBE2E3 Protein
    R&D Systems Recombinant & Natural Proteins for UBE2E3
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for UBE2E3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for UBE2E3
    GenScript Custom Purified and Recombinant Proteins Services for UBE2E3
    Novus Biologicals UBE2E3 Proteins
    Novus Biologicals UBE2E3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBE2E3 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    UBE2E3 for ontologies           About GeneDecksing



    UBE2E3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of UBE2E3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UBE2E3
    OriGene Custom Antibody Services for UBE2E3
    GenScript Custom Superior Antibodies Services for UBE2E3
    Novus Biologicals UBE2E3 Antibodies
    Abcam antibodies for UBE2E3
    Cloud-Clone Corp. Antibodies for UBE2E3 
    ThermoFisher Antibodies for UBE2E3
    LSBio Antibodies in human, mouse, rat for UBE2E3 

    Assay Products for UBE2E3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBE2E3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBE2E3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBE2E3 
    Cloud-Clone Corp. CLIAs for UBE2E3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q969T4

    ProtoNet protein and cluster: Q969T4

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2E3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2E3_HUMAN, Q969T4
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation
    of transepithelial sodium transport in renal cells. May be involved in cell growth arrest
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2E3:
    ubiquitin conjugating enzyme E2E3,homologous to yeast UBC4/5,expressed in skeletal muscle

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2E3 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI phenotypic allele for Ube2e3 (no phenotypes)

    UBE2E3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2E3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2E3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2E3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2E3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2E3
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2E3 (see all 34):
    hsa-miR-142-5p hsa-miR-485-3p hsa-miR-139-5p hsa-miR-16-1* hsa-miR-374a hsa-miR-3921 hsa-miR-548m hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidUBE2E3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2E3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2E3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBE2E3
    Sirion Biotech Customized adenovirus for overexpression of UBE2E3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UBE2E3 (see all 13)
    OriGene ORF clones in mouse, rat for UBE2E3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBE2E3 (NM_006357)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2E3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2E3
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2E3 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2E3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBE2E3
    Search LifeMap BioReagents cell lines for UBE2E3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2E3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2E3 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3DNA damage Role of SUMO in p53 regulation
    Proteolysis Putative SUMO-1 pathway0.33
    4Ubiquitin-Proteasome Dependent Proteolysis
    Ubiquitin-Proteasome Dependent Proteolysis
    5Remodeling of Adherens Junctions
    Remodeling of Adherens Junctions

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UBE2E3
        Proteolysis Putative SUMO-1 pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2E3
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for UBE2E3
        Proteolysis Putative SUMO-1 pathway

    4        Reactome Pathways for UBE2E3
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    2         Kegg Pathways  (Kegg details for UBE2E3):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
    Pathway: Protein modification; protein ubiquitination


    UBE2E3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2E3

    5/88 Interacting proteins for UBE2E3 (Q969T42, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 88)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000183574Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    ENSG00000223767Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    ENSG00000225452Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    ENSG00000227277Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    ENSG00000228405Q999422, 3MINT-62676 MINT-62752 MINT-62578 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0040008regulation of growth IEA--
    GO:0070534protein K63-linked ubiquitination IDA--
    GO:0070936protein K48-linked ubiquitination IDA--
    GO:0070979protein K11-linked ubiquitination IDA--

    UBE2E3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBE2E3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2E3 (UB2E3)

    5 HMDB Compounds for UBE2E3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    SodiumSodium (see all 2)7440-23-5--

    6 Novoseek inferred chemical compound relationships for UBE2E3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rotenone 56.5 1 17587308 (1)
    cysteine 32.7 2 10343118 (1), 15545318 (1)
    colchicine 27.8 1 17587308 (1)
    gtp 2.45 1 11032817 (1)
    steroid 0 1 15691896 (1)
    serine 0 1 10343118 (1)

    Search CenterWatch for drugs/clinical trials and news about UBE2E3 / UB2E3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2E3 gene (4 alternative transcripts): 
    NM_001278554.1  NM_001278555.1  NM_006357.3  NM_182678.2  

    Unigene Cluster for UBE2E3:

    Ubiquitin-conjugating enzyme E2E 3
    Hs.470804  [show with all ESTs]
    Unigene Representative Sequence: BM912832
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000602303 ENST00000602959 ENST00000602479 ENST00000602291 ENST00000410062(uc002unr.1)
    ENST00000602475 ENST00000602499 ENST00000602710 ENST00000602762 ENST00000602632
    ENST00000602888 ENST00000602837 ENST00000602970 ENST00000392415(uc002unq.1 uc010fri.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2E3
    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2E3 (see all 34):
    hsa-miR-142-5p hsa-miR-485-3p hsa-miR-139-5p hsa-miR-16-1* hsa-miR-374a hsa-miR-3921 hsa-miR-548m hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidUBE2E3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2E3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2E3
    Clone
    Products:
         
    OriGene clones in human, mouse for UBE2E3 (see all 13)
    OriGene ORF clones in mouse, rat for UBE2E3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBE2E3 (NM_006357)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2E3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2E3
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2E3 
                         Customized lentivirus expression plasmids for stable overexpression of UBE2E3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBE2E3
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2E3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2E3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2E3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2E3

    Additional mRNA sequence: 

    AB017644.1 AF085362.1 AK314145.1 BC003554.1 BC003687.1 BC092407.1 BT019345.1 

    20 DOTS entries:

    DT.218837  DT.95227459  DT.99940731  DT.99983990  DT.92451651  DT.100826030  DT.120950576  DT.95227487 
    DT.100031738  DT.102831523  DT.120950601  DT.100800490  DT.100826023  DT.95227461  DT.100717255  DT.40189481 
    DT.91824456  DT.91926280  DT.92451650  DT.95098679 

    24/393 AceView cDNA sequences (see all 393):

    W68616 CB143937 AU098426 AA448500 BM709745 BQ070497 AI038444 BE562759 
    CB135485 BE222487 AA864850 BQ441123 AI872803 BU630586 AA864949 BM927792 
    CR607535 BM707875 BG187677 AA731196 AU102616 AW661944 BM750299 BG756114 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2E3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCTGAAGG
    UBE2E3 Expression
    About this image


    See UBE2E3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2E3

    SOURCE GeneReport for Unigene cluster: Hs.470804

    UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
    Tissue specificity: Ubiquitously expressed at low levels. Highly expressed in skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including UBE2E3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBE2E3
    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2E3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2E3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2E3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2E3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2E3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBE2E3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2e31 , 5 ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog more5
    ubiquitin-conjugating enzyme E2E 31
    95.49(n)1
    100(a)1
      2 (47.15 cM)5
    221931  NM_009454.21  NP_033480.11 
     788681245 
    chicken
    (Gallus gallus)
    Aves UBE2E31 ubiquitin-conjugating enzyme E2E 3 90.82(n)
    99.52(a)
      424122  NM_001195424.1  NP_001182353.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2E36
    Uncharacterized protein
    92(a)
    1 ↔ 1
    GL343455.1(131378-414149)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77872 Xenopus laevis transcribed sequence with strong similarity more 86.27(n)    CD253593.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc559232 similar to ubiquitin-conjugating enzyme E2E 3, UBC4/5 more 83.53(n)   393895  BC042331.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta UbcD23 ubiquitin cycle ubiquitin conjugating
    enzyme
    86(a)
    (best of 4)
      2 32A5   --
    worm
    (Caenorhabditis elegans)
    Secernentea F52C6.126
    Protein F52C6.12
    50(a)
    possible ortholog
    II(1929149-1929953)


    ENSEMBL Gene Tree for UBE2E3 (if available)
    TreeFam Gene Tree for UBE2E3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2E3 gene
    UBE2D32  UBE2L62  UBE2D12  UBE2D42  UBE2E12  UBE2D22  UBE2E22  UBE2L32  
    18/24 SIMAP similar genes for UBE2E3 using alignment to 5 protein entries:     UB2E3_HUMAN (see all proteins) (see all similar genes):
    UBE2E1    UBE2D1    UBE2D3    UBE2D2    UBE2D4    UBE2E2
    HR6A    UBE2A    UBE2B    UBE2I    UBE2DNL    UBE2L3
    UBE2N    UBE2M    UBE2S    UBE2T    UBE2W    UBE2K

    UBE2E3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1959 SNPs in UBE2E3 are shown (see all 1959)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1164063721,2
    C--173698358(+) AATTGA/CTGATT 1 -- us2k10--------
    rs1483593161,2
    C--173698391(+) CTTTAC/TTTCTT 1 -- us2k10--------
    rs1929861831,2
    --173698427(+) GCTACA/GTTTCT 1 -- us2k10--------
    rs774270381,2
    C,F--173698457(+) TGAGCT/CTGGTT 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs2020916141,2
    --173698487(+) CACTC-/CAGTTTC 1 -- us2k10--------
    rs1853225451,2
    --173698586(+) CATGGA/CATTTT 1 -- us2k10--------
    rs752490831,2
    --173698669(+) CCTGAC/GGTCAT 1 -- us2k10--------
    rs1141333661,2
    F--173698691(+) AGAATG/AAGGAT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1508969731,2
    --173698697(+) AGGATC/TAGAAT 1 -- us2k10--------
    rs1898064911,2
    --173698777(+) TTCTCC/GCCTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2E3 (181831975 - 181941312 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for UBE2E3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2721202CNV Deletion23290073
    esv3605CNV Deletion18987735
    dgv17e194CNV Deletion18987734
    esv2721203CNV Deletion23290073
    esv270802CNV Insertion20981092
    esv9135CNV Loss19470904
    nsv875476CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2E3
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2E3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604151    OMIM disorders: --

    20/21 diseases for UBE2E3 (see all 21):    About MalaCards
    liddle syndrome    triple-a syndrome    parkinson's disease    prostate cancer, progression of
    celiac disease    wilms tumor    kaposi's sarcoma    cervical cancer
    sarcoma    prostatitis    hepatitis c    prostate cancer
    obesity    cervicitis    neuroblastoma    retinitis
    thyroiditis    hepatitis    gastric cancer    leukemia


    UBE2E3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    4 Novoseek inferred disease relationships for UBE2E3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinsonism juvenile autosomal recessive 89.6 4 12975291 (1), 16375772 (1), 16096643 (1), 19705877 (1)
    parkinson disease 57.9 4 12928331 (1), 19036992 (1), 16714300 (1), 15492001 (1)
    parkinsonism 48 3 16375772 (1), 12783850 (1), 14519684 (1)
    tumors 0 2 14507994 (1), 10421634 (1)

    Genetic Association Database (GAD): UBE2E3
    Human Genome Epidemiology (HuGE) Navigator: UBE2E3 (1 document)

    Export disorders for UBE2E3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2E3 gene, integrated from 9 sources (see all 156):
    (articles sorted by number of sources associating them with UBE2E3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin- conjugating enzyme. (PubMed id 10343118)1, 2, 3, 9 Ito K.... Okano Y. (1999)
    2. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PubMed id 15545318)1, 2, 9 Plafker S.M.... Macara I.G. (2004)
    3. Multiple common variants for celiac disease influenci ng immune gene expression. (PubMed id 20190752)1, 4 Dubois P.C....van Heel D.A. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells. (PubMed id 18614808)1, 9 Plafker K.S....Plafker S.M. (2008)
    8. Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. (PubMed id 10187858)1, 9 Desterro J.M.P.... Hay R.T. (1999)
    9. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PubMed id 11322894)1, 9 Ito K.... Okano Y. (2001)
    10. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1, 9 van Wijk S.J....Timmers H.T. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10477 HGNC: 12479 AceView: UBE2E3 Ensembl:ENSG00000170035 euGenes: HUgn10477
    ECgene: UBE2E3 Kegg: 10477 H-InvDB: UBE2E3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2E3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2E3 gene:
    Search GeneIP for patents involving UBE2E3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     EMD Millipore Mono- and Polyclonal Antibodies for the study of UBE2E3
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Purified and/or Recombinant UBE2E3 Protein
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Recombinant/Natural Proteins for UBE2E3 (UBE2E3)  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBE2E3   OriGene RNAi products in human, mouse, rat for UBE2E3  
     OriGene qPCR primer pairs and template standards for UBE2E3   OriGene Protein Over-expression Lysate for UBE2E3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for UBE2E3  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBE2E3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for UBE2E3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBE2E3   OriGene Custom Protein Services for UBE2E3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2E3
     QIAGEN SeqTarget long-range PCR primers for resequencing UBE2E3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2E3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2E3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2E3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2E3
     GenScript Custom Purified and Recombinant Proteins Services for UBE2E3 GenScript cDNA clones with any tag delivered in your preferred vector for UBE2E3
     GenScript Custom Assay Services for UBE2E3 GenScript Custom Superior Antibodies Services for UBE2E3
     GenScript Custom overexpressing Cell Line Services for UBE2E3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in UBE2E3 promoter
     Search Chromatin IP Primers for UBE2E3
     RT2 qPCR Primer Assay in human, mouse, rat UBE2E3
     GNC Network for UBE2E3
     SABiosciences PCR Arrays including human, mouse, rat UBE2E3
     Search Tocris compounds for UBE2E3 (UB2E3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     UBE2E3 antibodies
     UBE2E3 proteins
     UBE2E3 lysates
     Antibodies for UBE2E3
     See all of Abcam's Antibodies, Kits and Proteins for UBE2E3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for UBE2E3
     Antibodies for UBE2E3
     ELISAs for UBE2E3
     CLIAs for UBE2E3
     Search LifeMap BioReagents cell lines for UBE2E3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2E3
     SwitchGear 3'UTR luciferase reporter plasmids for UBE2E3
     Browse SwitchGear Promoter luciferase reporter plasmids for UBE2E3
     ThermoFisher Antibodies for UBE2E3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2E3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2E3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2E3
    Customized:
     lentivirus for stable overexpression of UBE2E3
     lentivirus expression plasmids for stable overexpression of UBE2E3
     adenovirus for overexpression of UBE2E3
     LSBio Antibodies in human, mouse, rat for UBE2E3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBE2E3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4