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Aliases for UBE2E3 Gene

Aliases for UBE2E3 Gene

  • Ubiquitin Conjugating Enzyme E2 E3 2 3
  • Ubiquitin-Conjugating Enzyme E2E 3 (Homologous To Yeast UBC4/5) 2 3
  • Ubiquitin-Conjugating Enzyme E2E 3 (UBC4/5 Homolog, Yeast) 2 3
  • Ubiquitin-Conjugating Enzyme E2-23 KDa 3 4
  • Ubiquitin Conjugating Enzyme E2E 3 3 5
  • E2 Ubiquitin-Conjugating Enzyme E3 3 4
  • Ubiquitin Carrier Protein E3 3 4
  • Ubiquitin-Protein Ligase E3 3 4
  • UBCH9 3 4
  • Ubiquitin-Conjugating Enzyme E2E 3 2
  • EC 63
  • EC 4
  • UbcM2 3
  • UBCE4 4

External Ids for UBE2E3 Gene

Previous GeneCards Identifiers for UBE2E3 Gene

  • GC02P180033
  • GC02P180529
  • GC02P181809
  • GC02P182047
  • GC02P181670
  • GC02P181553
  • GC02P173700

Summaries for UBE2E3 Gene

Entrez Gene Summary for UBE2E3 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2013]

GeneCards Summary for UBE2E3 Gene

UBE2E3 (Ubiquitin Conjugating Enzyme E2 E3) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Remodeling of Adherens Junctions. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2E3 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.

Gene Wiki entry for UBE2E3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2E3 Gene

Genomics for UBE2E3 Gene

Regulatory Elements for UBE2E3 Gene

Enhancers for UBE2E3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2E3 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2E3 Gene

180,967,248 bp from pter
181,076,585 bp from pter
109,338 bases
Plus strand

Genomic View for UBE2E3 Gene

Genes around UBE2E3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2E3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2E3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2E3 Gene

Proteins for UBE2E3 Gene

  • Protein details for UBE2E3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 E3
    Protein Accession:
    Secondary Accessions:
    • B2RAD6
    • D3DPG3
    • Q5U0R7
    • Q7Z4W4

    Protein attributes for UBE2E3 Gene

    207 amino acids
    Molecular mass:
    22913 Da
    Quaternary structure:
    • The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its import into the nucleus. Interacts with NEDD4L.

neXtProt entry for UBE2E3 Gene

Proteomics data for UBE2E3 Gene at MOPED

Post-translational modifications for UBE2E3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UBE2E3 Gene

Gene Families for UBE2E3 Gene

Protein Domains for UBE2E3 Gene

Suggested Antigen Peptide Sequences for UBE2E3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family.
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2E3: view

Function for UBE2E3 Gene

Molecular function for UBE2E3 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2E3,homologous to yeast UBC4/5,expressed in skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.

Enzyme Numbers (IUBMB) for UBE2E3 Gene

genes like me logo Genes that share phenotypes with UBE2E3: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2E3 Gene

Localization for UBE2E3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2E3 Gene

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a IPO11-dependent manner.

Subcellular locations from

Jensen Localization Image for UBE2E3 Gene COMPARTMENTS Subcellular localization image for UBE2E3 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for UBE2E3 Gene

Pathways & Interactions for UBE2E3 Gene

genes like me logo Genes that share pathways with UBE2E3: view

Pathways by source for UBE2E3 Gene

UniProtKB/Swiss-Prot Q969T4-UB2E3_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2E3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070534 protein K63-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2E3: view

No data available for SIGNOR curated interactions for UBE2E3 Gene

Drugs & Compounds for UBE2E3 Gene

(6) Drugs for UBE2E3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(5) Additional Compounds for UBE2E3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
  • Sodium
  • Sodium ion
genes like me logo Genes that share compounds with UBE2E3: view

Transcripts for UBE2E3 Gene

Unigene Clusters for UBE2E3 Gene

Ubiquitin-conjugating enzyme E2E 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2E3 Gene

No ASD Table

Relevant External Links for UBE2E3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2E3 Gene

mRNA expression in normal human tissues for UBE2E3 Gene

Protein differential expression in normal tissues from HIPED for UBE2E3 Gene

This gene is overexpressed in Amniocyte (16.6), Fetal Brain (15.7), Testis (13.2), and Pancreas (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBE2E3 Gene

SOURCE GeneReport for Unigene cluster for UBE2E3 Gene Hs.470804

mRNA Expression by UniProt/SwissProt for UBE2E3 Gene

Tissue specificity: Ubiquitously expressed at low levels. Highly expressed in skeletal muscle.
genes like me logo Genes that share expression patterns with UBE2E3: view

Protein tissue co-expression partners for UBE2E3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for UBE2E3 Gene

Orthologs for UBE2E3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2E3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBE2E3 35
  • 96.46 (n)
  • 100 (a)
UBE2E3 36
  • 99 (a)
(Canis familiaris)
Mammalia UBE2E3 35
  • 96.62 (n)
  • 100 (a)
UBE2E3 36
  • 100 (a)
(Mus musculus)
Mammalia Ube2e3 35
  • 95.49 (n)
  • 100 (a)
Ube2e3 16
Ube2e3 36
  • 100 (a)
(Pan troglodytes)
Mammalia UBE2E3 35
  • 100 (n)
  • 100 (a)
UBE2E3 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Ube2e3 35
  • 95.81 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia UBE2E3 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2E3 36
  • 79 (a)
(Gallus gallus)
Aves UBE2E3 35
  • 90.82 (n)
  • 99.52 (a)
UBE2E3 36
  • 100 (a)
(Anolis carolinensis)
Reptilia UBE2E3 36
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2e3 35
  • 85.51 (n)
  • 99.03 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.7787 35
(Danio rerio)
Actinopterygii ube2e3 35
  • 80.35 (n)
  • 95.65 (a)
zgc55923 35
ube2e3 36
  • 95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10862 37
  • 52 (a)
CG2574 37
  • 50 (a)
CG5440 37
  • 71 (a)
UbcD2 37
  • 86 (a)
CG2574 36
  • 38 (a)
CG5440 36
  • 65 (a)
UbcD2 36
  • 66 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons FUS9 35
  • 61.04 (n)
  • 58.78 (a)
(Oryza sativa)
Liliopsida Os07g0577400 35
  • 57.89 (n)
  • 60.53 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6406 36
  • 71 (a)
Species with no ortholog for UBE2E3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2E3 Gene

Gene Tree for UBE2E3 (if available)
Gene Tree for UBE2E3 (if available)

Paralogs for UBE2E3 Gene

genes like me logo Genes that share paralogs with UBE2E3: view

Variants for UBE2E3 Gene

Sequence variations from dbSNP and Humsavar for UBE2E3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2368192 - 181,062,865(+) GACAG(A/T)GGACC reference, missense
rs873255 -- 181,059,873(-) TGTAC(G/T)GTGAG intron-variant
rs873256 -- 181,059,624(-) ATTTC(A/T)AAGAG intron-variant
rs1829365 -- 181,020,894(-) TAATA(A/T)AAAAC intron-variant
rs1829366 -- 181,020,873(-) CAGTC(A/T)CCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2E3 Gene

Variant ID Type Subtype PubMed ID
nsv875476 CNV Loss 21882294
esv2721202 CNV Deletion 23290073
esv270802 CNV Insertion 20981092
dgv17e194 CNV Deletion 18987734
esv2721203 CNV Deletion 23290073
esv3605 CNV Deletion 18987735
esv9135 CNV Loss 19470904

Variation tolerance for UBE2E3 Gene

Residual Variation Intolerance Score: 56.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBE2E3 Gene

Disorders for UBE2E3 Gene

Relevant External Links for UBE2E3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBE2E3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2E3 Gene

Publications for UBE2E3 Gene

  1. cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin- conjugating enzyme. (PMID: 10343118) Ito K. … Okano Y. (Cytogenet. Cell Genet. 1999) 2 3 4 23 67
  2. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3 23
  3. The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells. (PMID: 18614808) Plafker K.S. … Plafker S.M. (Invest. Ophthalmol. Vis. Sci. 2008) 3 23
  4. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PMID: 17873885) Christensen D.E. … Klevit R.E. (Nat. Struct. Mol. Biol. 2007) 3 23
  5. Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PMID: 15545318) Plafker S.M. … Macara I.G. (J. Cell Biol. 2004) 3 23

Products for UBE2E3 Gene

Sources for UBE2E3 Gene