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UBE2E3 Gene

protein-coding GIFtS: 63

GC02P181553

ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)
(Previous name: ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.3.2.19 ^³
UBCE4 ^³
UBCH9 ^², ³, ⁵
UbcH9 ^¹, ³
UbcM2 ^², ³

Descriptions
Ubiquitin carrier protein E3 ^³
Ubiquitin-conjugating enzyme E2-23 kDa ^³
Ubiquitin-protein ligase E3 ^³
ubiquitin carrier protein ^²
ubiquitin-conjugating enzyme E2E 3 ^²
ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast) ^²
ubiquitin-conjugating enzyme E2E 3 (homologous to yeast UBC4/5) ^¹, ²
ubiquitin-protein ligase ^²

External Ids
HGNC: 12479¹
Entrez Gene: 10477²
UniProtKB: Q969T4³
Ensembl: ENSG00000170035⁷

Search outside databases for aliases for UBE2E3 gene

Previous GC identifers: GC02P180033 GC02P180529 GC02P181809 GC02P182047 GC02P181670

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2E3:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat

counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two

alternatively spliced transcript variants encoding the same protein have been found for this gene.

[provided by RefSeq]

UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Participates in the

regulation of transepithelial sodium transport in renal cells. May be involved in cell growth

arrest

Gene Wiki entry for UBE2E3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2E3 gene

Entrez Gene cytogenetic band: 2q32.1 Ensembl cytogenetic band: 2q31.3 HGNC cytogenetic band: 2q31.3

UBE2E3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P181553: (about GC identifiers)

Start:	181,553,345 bp from pter
End:	181,636,413 bp from pter
Size:	83,069 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 E3

Size: 207 amino acids; 22913 Da

Subunit: The ubiquitin-loaded form interacts specifically with importin-11 (IPO11), leading to its

import into the nucleus (By similarity). Interacts with NEDD4L

Subcellular location: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a

IPO11-dependent manner

Secondary accessions: Q5U0R7 Q7Z4W4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_006348.1 NP_872619.1

ENSEMBL proteins:

ENSP00000386788 ENSP00000376215 ENSP00000307109 ENSP00000386364 ENSP00000386445 ENSP00000386798

ENSP00000386825

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBE2E3 Protein
	Sigma-Aldrich Proteins for UBE2E3
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (UBE2E3)
	Human Recombinant Proteins from Abnova (UBE2E3)

OriGene Purified Recombinant Human Proteins (see all 2): UBE2E3

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005730	nucleolus	IDA	18029348
GO:0005737	cytoplasm	IEA	--

About this table

Antibodies for UBE2E3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE2E3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE2E3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2E3)
	Novus Biologicals Antibodies for UBE2E3

Assays for UBE2E3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q969T4

ProtoNet protein and cluster: Q969T4

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2E3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2E3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182678

Applied Biosystems Silencer® siRNAs for UBE2E3

Sigma-Aldrich siRNA and siRNA Panels for UBE2E3

Sigma-Aldrich shRNA Panels and shRNA for UBE2E3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2E3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_006357
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_006357
untagged cDNA clones in CMV expression vector (see all 2): NM_006357

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006357

UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Participates in the

regulation of transepithelial sodium transport in renal cells. May be involved in cell growth

arrest

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19

Genatlas biochemistry entry for UBE2E3:

ubiquitin conjugating enzyme E2E3,homologous to yeast UBC4/5,expressed in skeletal muscle

1 MGI phenotypic allele

for Ube2e3 (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005515	protein binding	IPI	14667819
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2E3 (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway
Hypoxia Signaling in the Cardiovascular System

GeneDecks UBE2E3 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2E3

5/29 Interacting proteins for UBE2E3 (Q969T4^{1, 2} ENSP00000307109³) via UniProtKB, MINT, and/or STRING (see all 29 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000183574	Q99942¹^,²	EBI-348496, EBI-348482 MINT-62676 MINT-62752 MINT-62578
ENSG00000206254	Q99942¹^,²	EBI-348496, EBI-348482 MINT-62676 MINT-62752 MINT-62578
RNF5	Q99942¹^,²	EBI-348496, EBI-348482 MINT-62676 MINT-62752 MINT-62578 EBI-348496, EBI-348482 MINT-62676 MINT-62752 MINT-62578
RNF5	Q99942¹^,²	EBI-348496, EBI-348482 MINT-62676 MINT-62752 MINT-62578 EBI-348496, EBI-348482 MINT-62676 MINT-62752 MINT-62578
ATXN1	P54253²	MINT-2868342

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0019941	modification-dependent protein catabolic process	IEA	--
GO:0040008	regulation of growth	IEA	--
GO:0043687	post-translational protein modification	IEA	--
GO:0051246	regulation of protein metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2E3
3 Novoseek chemical compound relationships for UBE2E3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colchicine	29.54	1	17587308 (1)
gtp	4.32	1	11032817 (1)
steroid	0.00	1	15691896 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2E3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2E3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_182678

Sigma-Aldrich siRNA and siRNA Panels for UBE2E3

Sigma-Aldrich shRNA Panels and shRNA for UBE2E3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006357 NM_182678

REFSEQ mRNAs for UBE2E3 gene (2 alternative transcripts):

NM_006357.2 NM_182678.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006357 NM_182678

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_006357
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_006357
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_006357

Additional cDNA sequence:

AB017644.1 AF085362.1 AK314145.1 BC003554.1 BC003687.1 BC092407.1 BT019345.1 CR593046.1

CR603132.1 CR607535.1 CR616134.1 CR621773.1 CR622410.1 CR624412.1

20 DOTS entries:

DT.218837 DT.95227459 DT.99940731 DT.99983990 DT.92451651 DT.100826030 DT.102831523 DT.120950576

DT.95227487 DT.100031738 DT.120950601 DT.100717255 DT.100800490 DT.100826023 DT.92451650 DT.40189481

DT.91824456 DT.91926280 DT.95098679 DT.95227461

24/393 AceView cDNA sequences (see all 393 ):

AA280089 BG187677 BE504278 AI348453 BU608985 AA731196 BI962902 BC003687

BE887721 AA016236 BG756114 CR603132 AA470054 CR624412 BU178864 BC003554

CB143937 BM847774 BQ020873 T31441 BE018406 BM970528 BQ441123 AB017644

highest scoring ESTs for UBE2E3:

AB017644 AA016236 AA018468 AA020993 AA022626 AA022773 AA025668 AA025669 AA054004 AA059201

Unigene Cluster for UBE2E3:

Ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, yeast)

Hs.470804 [show with all ESTs]

Unigene Representative Sequence: BM912832

GeneLoc Exon Structure

7 Ensembl transcripts including schematic representations:

ENST00000410062 ENST00000392415 ENST00000305934 ENST00000410114 ENST00000409247 ENST00000409513

ENST00000409596

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2E3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2E3

¹ / ² / ³

3 probe-sets matching UBE2E3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34850_at²^{, 3}	U95-A	3	1.00	0.36	1.00	1.00	AB017644	1.00	0.90	0.95	1
210024_s_at²^{, 3}	U133-A	3	1.00	0.47	--	--	AB017644	1.00	0.90	0.95	1
210024_s_at²	U133Plus2	3	1.00	0.47	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTCCTGAAGG

SOURCE GeneReport for Unigene cluster: Hs.470804
Expression variation in blood from EXPOLDB for UBE2E3
UniProtKB/Swiss-Prot: UB2E3_HUMAN, Q969T4
Tissue specificity: Ubiquitously expressed at low levels. Highly expressed in skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2E3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2E3¹	--	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, more	96.62(n) 100(a)	612823 XM_845749.1 XP_850842.1
chimpanzee (Pan troglodytes)	UBE2E3¹	--	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, more	100(n) 100(a)	459792 XM_001158573.1 XP_001158573.1
cow (Bos taurus)	UBE2E3¹	--	ubiquitin-conjugating enzyme E2E 3 (UBC4/5 homolog, more	96.14(n) 98.55(a)	534349 XM_614096.3 XP_614096.3
rat (Rattus norvegicus)	Ube2e3¹	--	ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog more	95.81(n) 100(a)	295686 XM_215754.4 XP_215754.2
mouse (Mus musculus)	Ube2e3^{1, 5}	2⁵	ubiquitin-conjugating enzyme E2E 3, UBC4/5 homolog more^{1, 5}	95.49(n)¹ 100(a)¹	22193¹ NM_009454.2¹ NP_033480.1¹ AF003346⁵ AK043446⁵ (see all 15)

About this table Species with no ortholog for UBE2E3

ENSEMBL Gene Tree for UBE2E3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2E3 gene

UBE2E1² UBE2E2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/511 NCBI SNPs in UBE2E3 are shown (see all 511 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 183)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs4595925^1,2	A,C,F,H	181552561(+)	`GAAGGT/CCTGGG`	2	--	ng5¹		8	EU EA WA	838
	rs28362474^1,2	F	181552789(+)	`GTGTCA/GTGTTT`	2	--	ng5¹		2	MN EA	1252
	rs28362473^1,2	F	181552739(+)	`CTTTCC/TAGAAC`	2	--	ng5¹ trp³		2	MN EA	1252
	rs2048977^1,2	A,C,F,H,O	181596842(-)	`AGCACG/CAACTT`	2	--	int¹		15	EU EA WA NA	1398
	rs2368189^1,2	A,C,F,H	181632540(+)	`taatcC/Agtgta`	2	--	int¹		12	NS EU EA WA NA	656
--	rs1401130^1,2	A,C,F,H	181602458(-)	`acttgA/Tataca`	2	--	int¹		7	EU EA WA NA	560
	rs1949453^1,2	A,C,F,H	181619019(+)	`TTGTAA/TGTTCT`	2	--	int¹		11	NA EA EU WA	886
	rs2048976^1,2	C,F,H,O	181597043(-)	`AGTATC/GAATAG`	2	--	int¹		12	MN EU EA WA NA	1164
	rs6717911^1,2	A,C,F,H	181579529(+)	`gttaaA/Gtatta`	2	--	int¹		4	EU EA WA	420
	rs10930951^1,2	A,C,F,H	181629968(+)	`atgagG/Caaaca`	2	--	int¹		4	EU EA WA	414

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HapMap Linkage Disequilibrium images for UBE2E3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604151

4 Novoseek disease relationships for UBE2E3 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinsonism juvenile autosomal recessive	88.28	3	12975291 (1), 16375772 (1), 16096643 (1)
parkinson disease	56.70	4	12928331 (1), 19036992 (1), 16714300 (1), 15492001 (1)
parkinsonism	45.88	3	16375772 (1), 12783850 (1), 14519684 (1)
tumors	0.00	2	14507994 (1), 10421634 (1)

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1 PharmGKB disease relationship for UBE2E3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/115 PubMed articles for UBE2E3 gene (see all 115 ):

cDNA cloning, characterization, and chromosome mapping of UBE2E3 (alias UbcH9), encoding an N-terminally extended human ubiquitin- conjugating enzyme. (PubMed id 10343118)^{1, 2, 3, 4} Ito K.... Okano Y. (1999)
Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import. (PubMed id 15545318)^{1, 3, 4} Plafker S.M.... Macara I.G. (2004)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The human ubiquitin conjugating enzyme, UBE2E3, is required for proliferation of retinal pigment epithelial cells. (PubMed id 18614808)^{1, 3} Plafker K.S....Plafker S.M. (2008)
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. (PubMed id 10187858)^{1, 3} Desterro J.M.P.... Hay R.T. (1999)
N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PubMed id 11322894)^{1, 3} Ito K.... Okano Y. (2001)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)³ Lim J....Zoghbi H.Y. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10477	HGNC: 12479	AceView: UBE2E3	Ensembl:ENSG00000170035	euGenes: HUgn10477
ECgene: UBE2E3	H-InvDB: UBE2E3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for UBE2E3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE2E3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2E3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2E3		Antibodies for UBE2E3
	Explore super-pooled esiRNAs		Proteins for UBE2E3
	Lentivirus-delivered shRNAs for UBE2E3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Tagged/untagged cDNA clones
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	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for UBE2E3

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UBE2E3 Gene at Home site.
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UBE2E3 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for UBE2E3

Summaries
for UBE2E3

Genomic Location
for UBE2E3

Proteins
for UBE2E3

Protein Domains/
Families
for UBE2E3

Gene Function
for UBE2E3

Pathways & Interactions
for UBE2E3

Drugs & Compounds
for UBE2E3

Transcripts
for UBE2E3

Expression
for UBE2E3

Orthologs
for UBE2E3

Paralogs
for UBE2E3

SNPs/Variants
for UBE2E3

Disorders & Mutations
for UBE2E3

Medical News
for UBE2E3

Publications
for UBE2E3

Search for UBE2E3

Genome Databases showing UBE2E3

Other Databases showing UBE2E3

Specialized Databases showing UBE2E3

Licensable Technologies
for UBE2E3

Services
for UBE2E3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2E3 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor UBE2E3

Summariesfor UBE2E3

Genomic Locationfor UBE2E3

Proteinsfor UBE2E3

Protein Domains/Familiesfor UBE2E3

Gene Functionfor UBE2E3

Pathways & Interactionsfor UBE2E3

Drugs & Compoundsfor UBE2E3

Transcriptsfor UBE2E3

Expression for UBE2E3

Orthologsfor UBE2E3

Paralogsfor UBE2E3

SNPs/Variantsfor UBE2E3

Disorders & Mutationsfor UBE2E3

Medical Newsfor UBE2E3

Publicationsfor UBE2E3

Search for UBE2E3

Genome Databases showing UBE2E3

Other Databases showing UBE2E3

Specialized Databases showing UBE2E3

Licensable Technologiesfor UBE2E3

Servicesfor UBE2E3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2E3

Summaries
for UBE2E3

Genomic Location
for UBE2E3

Proteins
for UBE2E3

Protein Domains/
Families
for UBE2E3

Gene Function
for UBE2E3

Pathways & Interactions
for UBE2E3

Drugs & Compounds
for UBE2E3

Transcripts
for UBE2E3

Expression
for UBE2E3

Orthologs
for UBE2E3

Paralogs
for UBE2E3

SNPs/Variants
for UBE2E3

Disorders & Mutations
for UBE2E3

Medical News
for UBE2E3

Publications
for UBE2E3

Licensable Technologies
for UBE2E3

Services
for UBE2E3