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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2E2 Gene

protein-coding   GIFtS: 60
GCID: GC03P023221

Ubiquitin-Conjugating Enzyme E2E 2

(Previous names: ubiquitin-conjugating enzyme E2E 2 (homologous to yeast...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2E 21 2     UBCH82 3
Ubiquitin-Conjugating Enzyme E2E 2 (Homologous To Yeast UBC4/5)1 2     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme E2E 2 (UBC4/5 Homolog, Yeast)1 2     Ubiquitin-Conjugating Enzyme E2 E22
Ubiquitin Carrier Protein E22 3     UbcH83
Ubiquitin-Protein Ligase E22 3     

External Ids:    HGNC: 124781   Entrez Gene: 73252   Ensembl: ENSG000001822477   OMIM: 6021635   UniProtKB: Q96LR53   

Export aliases for UBE2E2 gene to outside databases

Previous GC identifers: GC03U990078 GC03P023220


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBE2E2 Gene: 
UBE2E2 (ubiquitin-conjugating enzyme E2E 2) is a protein-coding gene. Diseases associated with UBE2E2 include metabolic acidosis, and muscular atrophy, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and ISG15 ligase activity. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2E2_HUMAN, Q96LR5
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination

Gene Wiki entry for UBE2E2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2E2 gene promoter:
         LHX3b/Lhx3b   STAT1   MEF-2A   PPAR-gamma1   GATA-6   SREBP-1a   FOXO4   LHX3a/Lhx3a   PPAR-gamma2   aMEF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2E2 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2E2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2E2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.2

UBE2E2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2E2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P023221:  view genomic region     (about GC identifiers)

Start:
23,244,511 bp from pter      End:
23,633,284 bp from pter
Size:
388,774 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2E2_HUMAN, Q96LR5 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 E2  
Size: 201 amino acids; 22255 Da
1 PDB 3D structure from and Proteopedia for UBE2E2:
1Y6L (3D)    

Explore the universe of human proteins at neXtProt for UBE2E2: NX_Q96LR5

Explore proteomics data for UBE2E2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96LR5

  • 4/6 DME Specific Peptides for UBE2E2 (Q96LR5) (see all 6)
     YPFKPPK  ICLDILK  TNRAEHDR  SKVLLSICSLLTD 

    UBE2E2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2E2 Protein Expression
    REFSEQ proteins: NP_689866.1  
    ENSEMBL proteins: 
     ENSP00000401053   ENSP00000392800   ENSP00000338340   ENSP00000379931   ENSP00000407501  
    Reactome Protein details: Q96LR5
    Human Recombinant Protein Products for UBE2E2: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry Q96LR5

    ProtoNet protein and cluster: Q96LR5

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2E2_HUMAN, Q96LR5
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2E2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2E2_HUMAN, Q96LR5
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2E2:
    ubiquitin conjugating enzyme E2E2,homologous to yeast UBC4/5,ubiquitously expressed, involved in selective protein
    degradation

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0042296ISG15 ligase activity IDA16428300
         
    UBE2E2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2E2:
     G0/1 arrest  Increased S DNA content  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2E2 
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    SwitchGear 3'UTR luciferase reporter plasmidUBE2E2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2E2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Common schema of ubiquitination0.36
    4Protein processing in endoplasmic reticulum
    Protein processing in endoplasmic reticulum

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UBE2E2
        Common schema of ubiquitination


    4        Reactome Pathways for UBE2E2
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    2         Kegg Pathways  (Kegg details for UBE2E2):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UB2E2_HUMAN, Q96LR5
    Pathway: Protein modification; protein ubiquitination


    UBE2E2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2E2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/100 Interacting proteins for UBE2E2 (Q96LR53 ENSP000003799314) via UniProtKB, MINT, STRING, and/or I2D (see all 100)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224994Q9HCM93, ENSP000004119494I2D: score=3 STRING: ENSP00000411949
    ENSG00000232839Q9HCM93, ENSP000003983554I2D: score=3 STRING: ENSP00000398355
    RNF5Q999423, ENSP000003642354I2D: score=2 STRING: ENSP00000364235
    ENSG00000206495Q9HCM93I2D: score=3 
    ENSG00000226437Q9HCM93I2D: score=3 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032020ISG15-protein conjugation IDA16428300
    GO:0070534protein K63-linked ubiquitination IDA--
    GO:0070936protein K48-linked ubiquitination IDA--
    GO:0070979protein K11-linked ubiquitination IDA--

    UBE2E2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2E2 (UB2E2)

    4 HMDB Compounds for UBE2E2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2E2 / UB2E2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2E2 gene: 
    NM_152653.3  

    Unigene Cluster for UBE2E2:

    Ubiquitin-conjugating enzyme E2E 2
    Hs.475688  [show with all ESTs]
    Unigene Representative Sequence: NM_152653
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000425792 ENST00000452894 ENST00000335798 ENST00000396703(uc010hfc.2 uc003ccg.2)
    ENST00000427371

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2E2 (see all 28):
    hsa-miR-520f hsa-miR-640 hsa-miR-300 hsa-miR-128 hsa-miR-501-3p hsa-miR-1257 hsa-miR-218 hsa-miR-502-3p
    SwitchGear 3'UTR luciferase reporter plasmidUBE2E2 3' UTR sequence
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2E2
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    Additional mRNA sequence: 

    AK057886.1 AK307075.1 BC022332.1 

    3 DOTS entries:

    DT.315038  DT.95125033  DT.100754439 

    24/152 AceView cDNA sequences (see all 152):

    AA887885 AW675798 BQ888699 BI495063 BF002750 CK905445 AA766277 AW293203 
    CB850618 BM716302 CB215463 BI827692 BU727324 BM701561 AA099871 CR617055 
    CF141387 BM688855 AI216404 AA296821 BM709539 BM674560 CD675501 H64991 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2E2 expression in normal human tissues (normalized intensities)      UBE2E2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTACTGGGAA
    UBE2E2 Expression
    About this image


    UBE2E2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Liver (Hepatobiliary System)
             Perivenous Hepatocytes Liver Lobule
     
     Blood (Cardiovascular System)
             Conventional Dendritic Cells II Spleen
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells II Spleen

    See UBE2E2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2E2

    SOURCE GeneReport for Unigene cluster: Hs.475688
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2E2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for UBE2E2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2e21 , 5 ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, more5
    ubiquitin-conjugating enzyme E2E 21
    91.87(n)1
    99.5(a)1
      14 (7.08 cM)5
    2187931  NM_144839.11  NP_659088.11 
     185735755 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2E26
    Uncharacterized protein
    79(a)
    1 ↔ 1
    GL343357.1(850041-995030)
    zebrafish
    (Danio rerio)
    Actinopterygii ube2e21 ubiquitin-conjugating enzyme E2E 2 79.6(n)
    89.55(a)
      445100  NM_001003494.1  NP_001003494.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG54406
    UbcD26
    Ubiquitin conjugating enzyme 2
    65(a)
    63(a)
    many ↔ many
    many ↔ many
    2L(1334245-1334932)
    2L(10765010-10767939)
    worm
    (Caenorhabditis elegans)
    Secernentea F52C6.126
    Protein F52C6.12
    50(a)
    possible ortholog
    II(1929149-1929953)


    ENSEMBL Gene Tree for UBE2E2 (if available)
    TreeFam Gene Tree for UBE2E2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2E2 gene
    UBE2D32  UBE2L62  UBE2D12  UBE2D22  UBE2E32  UBE2D42  UBE2L32  UBE2E12  
    18/23 SIMAP similar genes for UBE2E2 using alignment to 5 protein entries:     UB2E2_HUMAN (see all proteins) (see all similar genes):
    UBE2E3    UBE2E1    UBE2D3    UBE2D2    UBE2D1    UBE2D4
    UBE2A    UBE2B    UBE2N    UBE2H    UBE2L3    UBE2T
    UBE2I    UBE2M    UBE2NL    UBE2W    UBE2G1    UBE2V2

    UBE2E2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8051 SNPs in UBE2E2 are shown (see all 8051)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1859965721,2
    C--23246826(+) ATTTAA/GGAATT 1 -- int10--------
    rs1895824101,2
    --23246934(+) ACTTAC/TGACTA 1 -- int10--------
    rs1826086721,2
    --23247031(+) AATCAA/GGCATT 1 -- int10--------
    rs1869247001,2
    --23247047(+) AACAAA/TCCCAG 1 -- int10--------
    rs1906447361,2
    --23247131(+) TATCAA/GTGGCC 1 -- int10--------
    rs622526571,2
    C,F--23247172(+) TTTGGA/GTGAAA 1 -- int15Minor allele frequency- G:0.14NA WA EA 362
    rs1828649261,2
    --23247248(+) TTGGGA/GAATTT 1 -- int10--------
    rs1892545921,2
    C--23247309(+) TTCCTC/TTAATA 1 -- int10--------
    rs1931024251,2
    --23247317(+) ATATTC/TGGCAG 1 -- int10--------
    rs577472531,2
    C,F--23247318(+) TATTCG/AGCAGT 1 -- int13Minor allele frequency- A:0.12WA CSA 122

    HapMap Linkage Disequilibrium report for UBE2E2 (23244511 - 23494511 bp, first 250kb of UBE2E2)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for UBE2E2 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669216CNV Deletion23128226
    esv2725037CNV Deletion23290073
    esv2674431CNV Deletion23128226
    esv268283CNV Insertion20981092
    esv270258CNV Insertion20981092
    nsv3731CNV Insertion18451855
    esv25457CNV Loss19812545
    nsv526739CNV Loss19592680
    nsv876624CNV Loss21882294
    nsv236860CNV Loss16902084

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602163    OMIM disorders: --

    7 diseases for UBE2E2:    About MalaCards
    metabolic acidosis    muscular atrophy    parkinson's disease    esophageal squamous cell carcinoma
    esophagitis    squamous cell carcinoma    leukemia


    UBE2E2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    1 Novoseek inferred disease relationship for UBE2E2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 10.8 1 12730996 (1)

    Genetic Association Database (GAD): UBE2E2
    Human Genome Epidemiology (HuGE) Navigator: UBE2E2 (3 documents)

    Export disorders for UBE2E2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2E2 gene, integrated from 9 sources (see all 73):
    (articles sorted by number of sources associating them with UBE2E2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme. (PubMed id 9371400)1, 2, 3, 9 Kimura M.... Okano Y. (1997)
    2. A genome-wide association study in the Japanese popul ation identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C 2CD4B. (PubMed id 20818381)1, 4 Yamauchi T....SandbA (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PubMed id 18649358)1, 4 Ng D....Taylor P.R. (2008)
    5. Different roles for two ubiquitin-like domains of ISG15 in protein modification. (PubMed id 18356159)1, 9 Chang Y.G....Hu H.Y. (2008)
    6. The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8. (PubMed id 16583136)1, 9 Li J....Han H. (2006)
    7. Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. (PubMed id 16428300)1, 9 Takeuchi T....Yokosawa H. (2005)
    8. Identification and characterization of a novel endoge nous murine parkin mutation. (PubMed id 20089136)1, 9 Ramsey C.P. and Giasson B.I. (2010)
    9. E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages. (PubMed id 17873885)1, 9 Christensen D.E....Klevit R.E. (2007)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7325 HGNC: 12478 AceView: UBE2E2 Ensembl:ENSG00000182247 euGenes: HUgn7325
    ECgene: UBE2E2 Kegg: 7325 H-InvDB: UBE2E2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2E2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2E2 gene:
    Search GeneIP for patents involving UBE2E2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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