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Aliases for UBE2E2 Gene

Aliases for UBE2E2 Gene

  • Ubiquitin Conjugating Enzyme E2 E2 2 3 5
  • Ubiquitin-Conjugating Enzyme E2E 2 (Homologous To Yeast UBC4/5) 2 3
  • Ubiquitin-Conjugating Enzyme E2E 2 (UBC4/5 Homolog, Yeast) 2 3
  • E2 Ubiquitin-Conjugating Enzyme E2 3 4
  • Ubiquitin Carrier Protein E2 3 4
  • Ubiquitin-Protein Ligase E2 3 4
  • UBCH8 3 4
  • Ubiquitin-Conjugating Enzyme E2E 2 2
  • Ubiquitin Conjugating Enzyme E2E 2 3
  • Ubiquitin-Conjugating Enzyme E2 E2 3
  • EC 61
  • EC 4

External Ids for UBE2E2 Gene

Previous GeneCards Identifiers for UBE2E2 Gene

  • GC03U990078
  • GC03P023220

Summaries for UBE2E2 Gene

GeneCards Summary for UBE2E2 Gene

UBE2E2 (Ubiquitin Conjugating Enzyme E2 E2) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2E3.

UniProtKB/Swiss-Prot for UBE2E2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

Gene Wiki entry for UBE2E2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2E2 Gene

Genomics for UBE2E2 Gene

Regulatory Elements for UBE2E2 Gene

Enhancers for UBE2E2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G023159 1.3 FANTOM5 Ensembl ENCODE 17.9 -42.9 -42883 1.1 FOXA2 JUN ZMYM3 EBF1 RELA ZNF316 ZFHX2 EGR1 EED RELB UBE2E2 UBE2E2-AS1 PIR39843 RPL24P7
GH03G023035 1 Ensembl ENCODE 9.7 -166.3 -166278 1.9 PKNOX1 KLF1 EBF1 CTBP1 GATA3 ARID3A RELB CREM MTA2 ZBED1 UBE2E2 SALL4P5 RPL24P7
GH03G023070 1.1 Ensembl ENCODE 7 -131.2 -131202 2.0 FEZF1 ZNF335 ZNF366 CBX5 SCRT2 FOS ETV6 CREM ZBTB11 CEBPB UBE2E2 RPL24P7 SALL4P5
GH03G023202 1 ENCODE 7.1 +0.5 501 2.4 HDGF PKNOX1 FOXA2 ATF1 ARNT ZNF133 SIN3A GLI4 ZNF766 GLIS2 UBE2E2 HMGB1P5 UBE2E2-AS1 PIR45638
GH03G023567 0.9 Ensembl ENCODE 7 +365.0 364999 1.3 BHLHE40 USF2 CHD7 RAD51 IKZF1 RELB PRDM10 FOS IKZF2 PRDM4 UBE2E2 PIR46278 GC03P023480
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2E2 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2E2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149675 693 2201 HDGF FOXA2 ARNT ZNF133 SIN3A ZNF766 GLIS2 ELK1 ZNF143 ZNF263

Genomic Location for UBE2E2 Gene

23,203,007 bp from pter
23,591,793 bp from pter
388,787 bases
Plus strand

Genomic View for UBE2E2 Gene

Genes around UBE2E2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2E2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2E2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2E2 Gene

Proteins for UBE2E2 Gene

  • Protein details for UBE2E2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 E2
    Protein Accession:

    Protein attributes for UBE2E2 Gene

    201 amino acids
    Molecular mass:
    22255 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for UBE2E2 Gene

neXtProt entry for UBE2E2 Gene

Selected DME Specific Peptides for UBE2E2 Gene


Post-translational modifications for UBE2E2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for UBE2E2

Domains & Families for UBE2E2 Gene

Gene Families for UBE2E2 Gene

Suggested Antigen Peptide Sequences for UBE2E2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ubiquitin-conjugating enzyme family.
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2E2: view

Function for UBE2E2 Gene

Molecular function for UBE2E2 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2E2,homologous to yeast UBC4/5,ubiquitously expressed, involved in selective protein degradation
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-, as well as Lys-63-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.

Enzyme Numbers (IUBMB) for UBE2E2 Gene

Gene Ontology (GO) - Molecular Function for UBE2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 19549727
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
GO:0042296 ISG15 transferase activity IDA 16428300
genes like me logo Genes that share ontologies with UBE2E2: view
genes like me logo Genes that share phenotypes with UBE2E2: view

Animal Models for UBE2E2 Gene

MGI Knock Outs for UBE2E2:

Animal Model Products

CRISPR Products

miRNA for UBE2E2 Gene

miRTarBase miRNAs that target UBE2E2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2E2 Gene

Localization for UBE2E2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2E2 gene
Compartment Confidence
nucleus 2
cytosol 2
lysosome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBE2E2 Gene

Pathways & Interactions for UBE2E2 Gene

genes like me logo Genes that share pathways with UBE2E2: view

Pathways by source for UBE2E2 Gene

UniProtKB/Swiss-Prot Q96LR5-UB2E2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2E2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IMP 21628527
GO:0016567 protein ubiquitination IEA --
GO:0032020 ISG15-protein conjugation IDA 16428300
GO:0070534 protein K63-linked ubiquitination IDA 20061386
GO:0070936 protein K48-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2E2: view

No data available for SIGNOR curated interactions for UBE2E2 Gene

Drugs & Compounds for UBE2E2 Gene

(3) Drugs for UBE2E2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2E2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
genes like me logo Genes that share compounds with UBE2E2: view

Transcripts for UBE2E2 Gene

Unigene Clusters for UBE2E2 Gene

Ubiquitin-conjugating enzyme E2E 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2E2 Gene

No ASD Table

Relevant External Links for UBE2E2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2E2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2E2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2E2 Gene

This gene is overexpressed in Testis (12.2), Uterus (10.0), Pancreatic juice (8.7), and Ovary (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2E2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UBE2E2 Gene:


SOURCE GeneReport for Unigene cluster for UBE2E2 Gene:


Evidence on tissue expression from TISSUES for UBE2E2 Gene

  • Nervous system(4.8)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with UBE2E2: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2E2 Gene

Orthologs for UBE2E2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBE2E2 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia UBE2E2 35
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2E2 35
  • 100 (a)
(Pan troglodytes)
Mammalia UBE2E2 34
  • 99.83 (n)
(Canis familiaris)
Mammalia UBE2E2 34 35
  • 97.01 (n)
(Bos Taurus)
Mammalia UBE2E2 34 35
  • 91.87 (n)
(Mus musculus)
Mammalia Ube2e2 34 16 35
  • 91.87 (n)
(Rattus norvegicus)
Mammalia Ube2e2 34
  • 91.49 (n)
(Gallus gallus)
Aves UBE2E2 34
  • 87.86 (n)
(Anolis carolinensis)
Reptilia UBE2E2 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2e2 34
  • 82.59 (n)
(Danio rerio)
Actinopterygii ube2e1 35
  • 82 (a)
ube2e2 34
  • 79.6 (n)
fruit fly
(Drosophila melanogaster)
Insecta UbcD2 34 35
  • 69.34 (n)
CG5440 35
  • 65 (a)
CG2574 35
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007952 34
  • 65.45 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6406 35
  • 70 (a)
Species where no ortholog for UBE2E2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2E2 Gene

Gene Tree for UBE2E2 (if available)
Gene Tree for UBE2E2 (if available)

Paralogs for UBE2E2 Gene

genes like me logo Genes that share paralogs with UBE2E2: view

Variants for UBE2E2 Gene

Sequence variations from dbSNP and Humsavar for UBE2E2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000003529 -- 23,468,024(+) CAACA(C/T)TGAGG intron-variant
rs1000003595 -- 23,564,400(+) TAAAA(A/G)GAACT intron-variant
rs1000016962 -- 23,428,950(+) AAAAA(A/G)AAGAA intron-variant
rs1000020932 -- 23,240,126(+) TATTA(A/T)TTAAG intron-variant
rs1000034086 -- 23,308,584(+) GACAG(A/G)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2E2 Gene

Variant ID Type Subtype PubMed ID
dgv4702n100 CNV loss 25217958
esv25457 CNV loss 19812545
esv2669216 CNV deletion 23128226
esv2674431 CNV deletion 23128226
esv2725037 CNV deletion 23290073
esv3305981 CNV mobile element insertion 20981092
esv3325176 CNV insertion 20981092
esv3407384 CNV insertion 20981092
esv3446183 CNV insertion 20981092
esv3568647 CNV loss 25503493
esv3595562 CNV loss 21293372
esv3595563 CNV loss 21293372
nsv1002823 CNV loss 25217958
nsv1004417 CNV gain 25217958
nsv1005186 CNV gain 25217958
nsv1007373 CNV gain 25217958
nsv1109501 CNV deletion 24896259
nsv236860 CNV deletion 16902084
nsv3731 CNV insertion 18451855
nsv460479 CNV gain 19166990
nsv475797 CNV novel sequence insertion 20440878
nsv478001 CNV novel sequence insertion 20440878
nsv526739 CNV loss 19592680
nsv589947 CNV gain 21841781
nsv589948 CNV loss 21841781
nsv589949 CNV gain 21841781
nsv834636 CNV gain+loss 17160897
nsv955618 CNV deletion 24416366

Variation tolerance for UBE2E2 Gene

Residual Variation Intolerance Score: 35.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2E2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2E2 Gene

Disorders for UBE2E2 Gene

Relevant External Links for UBE2E2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBE2E2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2E2 Gene

Publications for UBE2E2 Gene

  1. cDNA cloning, characterization, and chromosome mapping of UBE2E2 encoding a human ubiquitin-conjugating E2 enzyme. (PMID: 9371400) Kimura M. … Okano Y. (Cytogenet. Cell Genet. 1997) 2 3 4 22 64
  2. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Identification and characterization of a novel endogenous murine parkin mutation. (PMID: 20089136) Ramsey C.P. … Giasson B.I. (J. Neurochem. 2010) 3 22 64
  5. Replication of a genome-wide case-control study of esophageal squamous cell carcinoma. (PMID: 18649358) Ng D. … Taylor P.R. (Int. J. Cancer 2008) 3 46 64

Products for UBE2E2 Gene

Sources for UBE2E2 Gene

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