Aliases for UBE2E1 Gene
External Ids for UBE2E1 Gene
Previous GeneCards Identifiers for UBE2E1 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
GeneCards Summary for UBE2E1 Gene
UBE2E1 (Ubiquitin-Conjugating Enzyme E2E 1) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L6.
UniProtKB/Swiss-Prot for UBE2E1 Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes Lys-48-linked polyubiquitination.