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Aliases for UBE2E1 Gene

Aliases for UBE2E1 Gene

  • Ubiquitin Conjugating Enzyme E2 E1 2 3
  • Ubiquitin-Conjugating Enzyme E2E 1 (Homologous To Yeast UBC4/5) 2 3
  • Ubiquitin-Conjugating Enzyme E2E 1 (UBC4/5 Homolog, Yeast) 2 3
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme E1 3 4
  • Ubiquitin Conjugating Enzyme E2E 1 3 5
  • E2 Ubiquitin-Conjugating Enzyme E1 3 4
  • Ubiquitin Carrier Protein E1 3 4
  • Ubiquitin-Protein Ligase E1 3 4
  • UBCH6 3 4
  • Ubiquitin-Conjugating Enzyme E2E 1 2
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4

External Ids for UBE2E1 Gene

Previous GeneCards Identifiers for UBE2E1 Gene

  • GC03M023441
  • GC03P023529
  • GC03P023697
  • GC03P023822
  • GC03P023793
  • GC03P023847

Summaries for UBE2E1 Gene

Entrez Gene Summary for UBE2E1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for UBE2E1 Gene

UBE2E1 (Ubiquitin Conjugating Enzyme E2 E1) is a Protein Coding gene. Among its related pathways are Mitotic Metaphase and Anaphase and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2E1 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes Lys-48-linked polyubiquitination.

Gene Wiki entry for UBE2E1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2E1 Gene

Genomics for UBE2E1 Gene

Regulatory Elements for UBE2E1 Gene

Enhancers for UBE2E1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2E1 on UCSC Golden Path with GeneCards custom track

Promoters for UBE2E1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2E1 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2E1 Gene

Chromosome:
3
Start:
23,805,893 bp from pter
End:
23,891,640 bp from pter
Size:
85,748 bases
Orientation:
Plus strand

Genomic View for UBE2E1 Gene

Genes around UBE2E1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2E1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2E1 Gene

Proteins for UBE2E1 Gene

  • Protein details for UBE2E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51965-UB2E1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 E1
    Protein Accession:
    P51965
    Secondary Accessions:
    • B2RBX4
    • C9J8K2
    • K4DI90

    Protein attributes for UBE2E1 Gene

    Size:
    193 amino acids
    Molecular mass:
    21404 Da
    Quaternary structure:
    • Interacts with RNF14.

    Three dimensional structures from OCA and Proteopedia for UBE2E1 Gene

    Alternative splice isoforms for UBE2E1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2E1 Gene

Proteomics data for UBE2E1 Gene at MOPED

Post-translational modifications for UBE2E1 Gene

Other Protein References for UBE2E1 Gene

Antibody Products

  • R&D Systems Antibodies for UBE2E1 (UbcH6/UBE2E1)

Domains & Families for UBE2E1 Gene

Gene Families for UBE2E1 Gene

Protein Domains for UBE2E1 Gene

Suggested Antigen Peptide Sequences for UBE2E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51965

UniProtKB/Swiss-Prot:

UB2E1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2E1: view

Function for UBE2E1 Gene

Molecular function for UBE2E1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2E1 Gene

Gene Ontology (GO) - Molecular Function for UBE2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBE2E1: view
genes like me logo Genes that share phenotypes with UBE2E1: view

Animal Model Products

miRNA for UBE2E1 Gene

miRTarBase miRNAs that target UBE2E1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2E1 Gene

Localization for UBE2E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2E1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2E1 Gene COMPARTMENTS Subcellular localization image for UBE2E1 gene
Compartment Confidence
cytosol 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for UBE2E1 Gene

Pathways & Interactions for UBE2E1 Gene

SuperPathways for UBE2E1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 APC-Cdc20 mediated degradation of Nek2A
3 Antigen processing- Ubiquitination and Proteasome degradation
4 Cell Cycle, Mitotic
.61
5 Cellular Senescence
genes like me logo Genes that share pathways with UBE2E1: view

UniProtKB/Swiss-Prot P51965-UB2E1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0008152 metabolic process IEA --
GO:0016567 protein ubiquitination IDA 9990509
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS --
genes like me logo Genes that share ontologies with UBE2E1: view

No data available for SIGNOR curated interactions for UBE2E1 Gene

Drugs & Compounds for UBE2E1 Gene

(4) Drugs for UBE2E1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2E1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2E1: view

Transcripts for UBE2E1 Gene

Unigene Clusters for UBE2E1 Gene

Ubiquitin-conjugating enzyme E2E 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2E1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - - -

Relevant External Links for UBE2E1 Gene

GeneLoc Exon Structure for
UBE2E1
ECgene alternative splicing isoforms for
UBE2E1

Expression for UBE2E1 Gene

mRNA expression in normal human tissues for UBE2E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2E1 Gene

This gene is overexpressed in Breast (45.4) and Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2E1 Gene



SOURCE GeneReport for Unigene cluster for UBE2E1 Gene Hs.164853

genes like me logo Genes that share expression patterns with UBE2E1: view

Protein tissue co-expression partners for UBE2E1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2E1 Gene

Orthologs for UBE2E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2E1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2E1 35
  • 92.75 (n)
  • 99.48 (a)
dog
(Canis familiaris)
Mammalia UBE2E1 35
  • 97.06 (n)
  • 100 (a)
UBE2E1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2e1 35
  • 91.02 (n)
  • 98.96 (a)
Ube2e1 16
Ube2e1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2E1 35
  • 100 (n)
  • 100 (a)
UBE2E1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2e1 35
  • 91.54 (n)
  • 98.96 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2E1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2E1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2E1 35
  • 87.05 (n)
  • 99.48 (a)
UBE2E1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2E1 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75971 35
ube2e1 35
  • 83.13 (n)
  • 98.21 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2e1 35
  • 79.5 (n)
  • 91.38 (a)
ube2e2 36
  • 80 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4084 35
fruit fly
(Drosophila melanogaster)
Insecta CG10862 37
  • 51 (a)
CG2574 37
  • 47 (a)
CG5440 37
  • 70 (a)
UbcD2 37
  • 87 (a)
CG2574 36
  • 37 (a)
ManyToMany
CG5440 36
  • 64 (a)
ManyToMany
UbcD2 36
  • 64 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.1978 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6467 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6406 36
  • 71 (a)
OneToMany
Species with no ortholog for UBE2E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2E1 Gene

ENSEMBL:
Gene Tree for UBE2E1 (if available)
TreeFam:
Gene Tree for UBE2E1 (if available)

Paralogs for UBE2E1 Gene

genes like me logo Genes that share paralogs with UBE2E1: view

Variants for UBE2E1 Gene

Sequence variations from dbSNP and Humsavar for UBE2E1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_061868 -
rs14712 -- 23,891,143(-) TTTTT(A/T)AAACA utr-variant-3-prime
rs1026406 -- 23,827,469(+) taagt(A/C)tgtca intron-variant
rs1026407 -- 23,827,978(+) TCTTT(C/G)CTTTT intron-variant
rs1026408 -- 23,828,174(+) GAAGA(G/T)GCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2E1 Gene

Variant ID Type Subtype PubMed ID
nsv834637 CNV Loss 17160897

Variation tolerance for UBE2E1 Gene

Residual Variation Intolerance Score: 42.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBE2E1 Gene

Disorders for UBE2E1 Gene

Relevant External Links for UBE2E1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2E1

No disorders were found for UBE2E1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2E1 Gene

Publications for UBE2E1 Gene

  1. Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2- F1) and characterization of their interaction with E6-AP and RSP5. (PMID: 8576257) Nuber U. … Scheffner M. (J. Biol. Chem. 1996) 2 3 4 67
  2. E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP- ribosylation factor domain protein 1). (PMID: 15684077) Vichi A. … Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 23
  3. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PMID: 11322894) Ito K. … Okano Y. (Eur. J. Biochem. 2001) 3 23
  4. Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes. (PMID: 10866800) Nyman T.A. … Kalkkinen N. (Eur. J. Biochem. 2000) 3 23
  5. Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. (PMID: 9990509) Anan T. … Nakao M. (Genes Cells 1998) 3 23

Products for UBE2E1 Gene

Sources for UBE2E1 Gene

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