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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2E1 Gene

protein-coding   GIFtS: 62
GCID: GC03P023847

ubiquitin-conjugating enzyme E2E 1

(Previous names: ubiquitin-conjugating enzyme E2E 1 (homologous to yeast...)
 Explore 5 diseases affiliated with
UBE2E1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UBE2E1    

Aliases
for UBE2E1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin-Conjugating Enzyme E2E 11 2     Ubiquitin-Protein Ligase E12 3
Ubiquitin-Conjugating Enzyme E2E 1 (Homologous To Yeast UBC4/5)1 2     UBCH62 3
Ubiquitin-Conjugating Enzyme E2E 1 (UBC4/5 Homolog, Yeast)1 2     EC 6.3.2.193 8
UbcH61 3     Ubiquitin-Conjugating Enzyme E2 E12
Ubiquitin Carrier Protein E12 3     

External Ids:    HGNC: 124771   Entrez Gene: 73242   Ensembl: ENSG000001701427   OMIM: 6029165   UniProtKB: P519653   

Export aliases for UBE2E1 gene to outside databases

Previous GC identifers: GC03M023441 GC03P023529 GC03P023697 GC03P023822 GC03P023793


Summaries
for UBE2E1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UBE2E1:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or
E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the
E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms
have been found for this gene. (provided by RefSeq, Jan 2011)

UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the
covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal
proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination

Gene Wiki entry for UBE2E1


Genomic Views
for UBE2E1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2E1 gene promoter:
         STAT1   FOXD1   Pax-2   POU3F2 (N-Oct-5b)   Pax-2a   FOXL1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBE2E1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2E1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.2

UBE2E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2E1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P023847:  view genomic region     (about GC identifiers)

Start:
 23,847,394 bp from pter      End:
 23,932,807 bp from pter
Size:
 85,414 bases      Orientation:
 plus strand

Proteins
for UBE2E1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 E1  
Size: 193 amino acids; 21404 Da
Subunit: Interacts with RNF14
Subcellular location: Nucleus
2 PDB 3D structures from and Proteopedia for UBE2E1:
1XR9 (3D)        3BZH (3D)    
Secondary accessions: B2RBX4 C9J8K2
Alternative splicing: 2 isoforms:  P51965-1   P51965-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2E1: NX_P51965

Post-translational modifications:

  • ISGylation suppresses ubiquitin E2 enzyme activity1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51965

    • 4/6 DME Specific Peptides for UBE2E1 (P51965) (see all 6)
     YPFKPPK  ICLDILK  TNRAEHDR  SKVLLSICSLLTD 

    UBE2E1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001189405.1  NP_003332.1  NP_872607.1  

    ENSEMBL proteins: 
     ENSP00000303709   ENSP00000329113   ENSP00000410652   ENSP00000411351   ENSP00000393088  
    Reactome Protein details: P51965
    Human Recombinant Protein Products: 
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    Novus Biologicals UBE2E1 Protein
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    ProSpec Recombinant Protein for UBE2E1
    Uscn Proteins for UBE2E1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA16307923
    GO:0005634nucleus IDA18845142
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--


    UBE2E1 for ontologies           About GeneDecksing



    UBE2E1 Antibody Products: 
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    Assay Products for UBE2E1: 
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    Uscn ELISAs and CLIAs for UBE2E1

    Protein Domains /
    Families
    for UBE2E1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UBE2E1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P51965

    ProtoNet protein and cluster: P51965

    1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Function
    for UBE2E1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the
    covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal
    proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

    Enzyme Number (IUBMB): EC 6.3.2.191 2

    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2E1 (see all 21):
    hsa-miR-495 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-181a-2* hsa-miR-105 hsa-miR-7-1* hsa-miR-542-3p hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmid: UBE2E1 3' UTR sequence
    Inhib. RNA
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UBE2E1

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2E1 (see all 3)
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    Cell Line
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    Search LifeMap BioReagents cell lines for UBE2E1

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15247280
    GO:0005515protein binding IPI19690564
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0042296ISG15 ligase activity IDA16428300


    UBE2E1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for UBE2E1:
     Synthetic lethal with Ras 

    Animal Models:
         1 MGI phenotypic allele for Ube2e1 (no phenotypes)

    UBE2E1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UBE2E1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/15 pathways (see all 15)
    		APC/C:Cdh1-mediated degradation of Skp20.74
    		APC/C:Cdc20 mediated degradation of mitotic proteins0.69
    		APC/C:Cdc20 mediated degradation of Securin0.74
    		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.69
    		Degradation of multiubiquitinated Securin0.74
    		Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins0.68
    		Autodegradation of Cdh1 by Cdh1:APC/C0.70
    		Regulation of APC/C activators between G1/S and early anaphase0.62
    2APC-Cdc20 mediated degradation of Nek2A
    8/10 pathways (see all 10)
    		Degradation of multiubiquitinated Nek2A1.00
    		Degradation of multiubiquitinated Cyclin B0.76
    		APC-Cdc20 mediated degradation of Nek2A1.00
    		Mitotic Spindle Checkpoint0.75
    		Inactivation of APC/C via direct inhibition of the APC/C complex0.78
    		Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.60
    		Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.78
    		Phosphorylation of the APC/C0.54
    3M Phase
    		M Phase1.00
    		Mitotic Anaphase0.85
    		Mitotic M-M/G1 phases0.88
    		Separation of Sister Chromatids0.80
    		Mitotic Metaphase and Anaphase0.85
    4Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    		Ubiquitin mediated proteolysis0.36
    5Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for UBE2E1
        Common schema of ubiquitination
    Proteolysis Putative ubiquitin pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2E1
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for UBE2E1
        Proteolysis Putative ubiquitin pathway

    5/41        Reactome Pathways for UBE2E1 (see all 41)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Phosphorylation of the APC/C
    APC/C:Cdc20 mediated degradation of Securin
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A
    Antigen processing: Ubiquitination & Proteasome degradation


    2         Kegg Pathways  (Kegg details for UBE2E1):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965
    Pathway: Protein modification; protein ubiquitination


    UBE2E1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2E1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/184 Interacting proteins for UBE2E1 (P519651, 2, 3 ENSP000003037094) via UniProtKB, MINT, STRING, and/or I2D (see all 184)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF5Q999422, 3, ENSP000003642354MINT-62577 MINT-62675 MINT-62751 I2D: score=5 STRING: ENSP00000364235
    ZNRF1Q8ND251, 3, ENSP000003350914EBI-348546,EBI-2129250 I2D: score=2 STRING: ENSP00000335091
    RNF11Q9Y3C51, 3, ENSP000002427194EBI-348546,EBI-2129167 I2D: score=2 STRING: ENSP00000242719
    PAEPP094663, ENSP000002775084I2D: score=3 STRING: ENSP00000277508
    UBE2G1P622533, ENSP000003801784I2D: score=3 STRING: ENSP00000380178
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000209protein polyubiquitination IDA15247280
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS8576257
    GO:0007094mitotic cell cycle spindle assembly checkpoint TAS--


    UBE2E1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for UBE2E1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBE2E1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2E1

    4 HMDB Compounds for UBE2E1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    1 Novoseek chemical compound relationship for UBE2E1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 29.2 1 9990509 (1)

    Search CenterWatch for drugs/clinical trials and news about UBE2E1 / UB2E1 

    Transcripts
    for UBE2E1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UBE2E1 gene (3 alternative transcripts): 
    NM_001202476.1  NM_003341.4  NM_182666.2  

    Unigene Cluster for UBE2E1:

    Ubiquitin-conjugating enzyme E2E 1
    Hs.164853  [show with all ESTs]
    Unigene Representative Sequence: NM_003341
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306627(uc003cch.3 uc003cci.3) ENST00000484048 ENST00000346855
    ENST00000495141 ENST00000481622 ENST00000442670 ENST00000467766(uc011awh.2)
    ENST00000424381(uc021wua.1) ENST00000475680 ENST00000452012 ENST00000493707


    miRNA
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    8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2E1 (see all 21):
    hsa-miR-495 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-181a-2* hsa-miR-105 hsa-miR-7-1* hsa-miR-542-3p hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmid: UBE2E1 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK295354.1 AK314854.1 BC009139.1 X92963.1 

    11 DOTS entries:

    DT.318024  DT.95277632  DT.97765958  DT.91742794  DT.91742798  DT.95277631  DT.120907446  DT.120907453 
    DT.95303824  DT.100796684  DT.75180231 

    24/231 AceView cDNA sequences (see all 231):

    BX486969 BI835626 AI973239 CD364807 NM_182666 N22211 NM_003341 W25345 
    BF969751 CD106559 CB131622 CF140057 CR622042 BQ015123 BM757766 AA173713 
    BU632355 BE046471 CR624061 BQ924649 BM762205 BQ009648 AI022520 BM090873 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2E1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
    SP1:        -     -           -           -     -           -                                 
    SP2:              -           -           -     -           -                                 
    SP3:                          -           -     -           -                                 
    SP4:                          -           -                 -                                 
    SP5:        -     -     -     -           -     -           -                                 


    ECgene alternative splicing isoforms for UBE2E1

    Expression
    for UBE2E1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2E1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAGAATGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See UBE2E1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2E1

    SOURCE GeneReport for Unigene cluster: Hs.164853
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2E1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    Orthologs
    for UBE2E1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2E1 gene from 7/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UBE2E11 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, more 81.91(n)
    92.02(a)    		   420653  XM_001235065.2  XP_001235066.2 
    lizard
    (Anolis carolinensis)    		 Reptilia UBE2E16
    		 --
    		 100(a)
    		 1 ↔ 1
    		 GL343357.1(686795-701314)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CF284208.12   -- 81.99(n)    CF284208.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii ube2e11 ubiquitin-conjugating enzyme E2E 1 79.51(n)
    91.15(a)    		   563542  NM_001103116.1  NP_001096586.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta UbcD21 , 3 ubiquitin cycle ubiquitin conjugating enzyme3
    Ubiquitin conjugating enzyme 21    		 87(a)
    (best of 4)3
    66.85(n)1
    81.32(a)1    		   2 32A53
    344871  NM_164943.11  NP_723616.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons FUS91 constitutive photomorphogenesis protein 10 60.14(n)
    56.08(a)    		   820557  NM_112201.4  NP_566459.2 
    rice
    (Oryza sativa)    		 Liliopsida Os07g05774001 hypothetical protein 59.38(n)
    59.6(a)    		   4343707  NM_001066623.1  NP_001060088.1 


    ENSEMBL Gene Tree for UBE2E1 (if available)
    TreeFam Gene Tree for UBE2E1 (if available) 

    Paralogs
    for UBE2E1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2E1 gene
    UBE2D32  ENSG000002586772  UBE2L62  UBE2D12  UBE2D22  UBE2W2  UBE2E32  UBE2D42  
    UBE2E22  UBE2L32  
    18/26 SIMAP similar genes for UBE2E1 using alignment to 4 protein entries:     UB2E1_HUMAN (see all proteins) (see all similar genes):
    UBE2E3    UBE2D1    UBE2D3    UBE2D4    UBE2D2    UBE2E2
    UBE2A    HR6A    UBE2B    UBE2H    UBE2L3    UBE2N
    UBE2T    UBE2W    UBE2DNL    UBE2I    UBE2M    UBE2V2

    UBE2E1 for paralogs           About GeneDecksing



    Genomic Variants
    for UBE2E1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1552 NCBI SNPs in UBE2E1 are shown (see all 1552)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs600783051,2
    		C,--23845853(+) TCCTGA/GAACCA 2 -- us2k12Minor allele frequency- G:0.10WA 120
    rs1855020251,2
    		--23845913(+) TTTCAA/GTGGTG 2 -- us2k10--------
    rs1446107961,2
    		--23845960(+) TATGAC/TCCTGA 2 -- us2k10--------
    rs1397599531,2
    		--23846036(+) AGGGAC/TTGAGC 2 -- us2k10--------
    rs753567831,2
    		F,--23846107(+) AGAAGG/AAGTTC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1453822571,2
    		--23846110(+) AGGAGC/TTCGGC 2 -- us2k10--------
    rs556464511,2
    		C,--23846141(+) TTTCCT/AGGTTA 2 -- us2k12Minor allele frequency- A:0.11WA 120
    rs766545561,2
    		C,F,--23846199(+) AAGCCA/GCTGTT 2 -- us2k11Minor allele frequency- G:0.03NA 120
    rs613855011,2
    		C,--23846265(+) CTGAGG/CCTGTC 2 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1907064881,2
    		--23846360(+) AAAAGG/TTGAGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2E1 (23847394 - 23932807 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UBE2E1: --

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    Disorders / Diseases
    for UBE2E1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UBE2E1 for disorders           About GeneDecksing

    OMIM gene information: 602916    OMIM disorders: --

    5 diseases for UBE2E1:    About MalaCards
    limb-girdle muscular dystrophy type 2h    limb-girdle muscular dystrophy    muscular dystrophy    muscular atrophy
    herpes simplex


    Export disorders for UBE2E1 gene to outside databases

    Publications
    for UBE2E1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2E1 gene, integrated from 9 sources (see all 84):
    (articles sorted by number of sources associating them with UBE2E1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2- F1) and characterization of their interaction with E6-AP and RSP5. (PubMed id 8576257)1, 2, 3 Nuber U.... Scheffner M. (1996)
    2. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. (PubMed id 18845142)1, 2 Espinosa A....Wahren-Herlenius M. (2008)
    3. Link between the Ubiquitin Conjugation System and the ISG15 Conjugation System: ISG15 Conjugation to the UbcH6 Ubiquitin E2 Enzyme. (PubMed id 16428300)1, 2 Takeuchi T....Yokosawa H. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). (PubMed id 15684077)1, 9 Vichi A....Vaughan M. (2005)
    6. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PubMed id 11322894)1, 9 Ito K.... Okano Y. (2001)
    7. Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes. (PubMed id 10866800)1, 9 Nyman T.A....Kalkkinen N. (2000)
    8. Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. (PubMed id 9990509)1, 9 Anan T....Nakao M. (1998)
    9. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    10. Human RNF169 is a negative regulator of the ubiquitin-dependent response to DNA double-strand breaks. (PubMed id 22492721)1 Poulsen M.... Mailand N. (2012)

    External Searches for UBE2E1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing UBE2E1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7324 HGNC: 12477 AceView: UBE2E1 Ensembl:ENSG00000170142 euGenes: HUgn7324
    ECgene: UBE2E1 Kegg: 7324 H-InvDB: UBE2E1

    Other Databases showing UBE2E1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UBE2E1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2E1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UBE2E1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UBE2E1 gene:
    Search GeneIP for patents involving UBE2E1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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