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Aliases for UBE2E1 Gene

Aliases for UBE2E1 Gene

  • Ubiquitin-Conjugating Enzyme E2E 1 2 3
  • UBCH6 3 4 6
  • Ubiquitin-Conjugating Enzyme E2E 1 (Homologous To Yeast UBC4/5) 2 3
  • Ubiquitin-Conjugating Enzyme E2E 1 (UBC4/5 Homolog, Yeast) 2 3
  • Ubiquitin Carrier Protein E1 3 4
  • Ubiquitin-Protein Ligase E1 3 4
  • EC 6.3.2.19 4 63
  • Ubiquitin-Conjugating Enzyme E2 E1 3

External Ids for UBE2E1 Gene

Previous GeneCards Identifiers for UBE2E1 Gene

  • GC03M023441
  • GC03P023529
  • GC03P023697
  • GC03P023822
  • GC03P023793
  • GC03P023847

Summaries for UBE2E1 Gene

Entrez Gene Summary for UBE2E1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

GeneCards Summary for UBE2E1 Gene

UBE2E1 (Ubiquitin-Conjugating Enzyme E2E 1) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cell Cycle, Mitotic. GO annotations related to this gene include ubiquitin-protein transferase activity and ISG15 transferase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2E1 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes Lys-48-linked polyubiquitination.

Gene Wiki entry for UBE2E1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2E1 Gene

Genomics for UBE2E1 Gene

Regulatory Elements for UBE2E1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2E1 Gene

Start:
23,805,893 bp from pter
End:
23,891,640 bp from pter
Size:
85,748 bases
Orientation:
Plus strand

Genomic View for UBE2E1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2E1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2E1 Gene

Proteins for UBE2E1 Gene

  • Protein details for UBE2E1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51965-UB2E1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 E1
    Protein Accession:
    P51965
    Secondary Accessions:
    • B2RBX4
    • C9J8K2
    • K4DI90

    Protein attributes for UBE2E1 Gene

    Size:
    193 amino acids
    Molecular mass:
    21404 Da
    Quaternary structure:
    • Interacts with RNF14

    Three dimensional structures from OCA and Proteopedia for UBE2E1 Gene

    Alternative splice isoforms for UBE2E1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2E1 Gene

Proteomics data for UBE2E1 Gene at MOPED

Post-translational modifications for UBE2E1 Gene

Other Protein References for UBE2E1 Gene

Antibody Products

  • R&D Systems Antibodies for UBE2E1 (UbcH6/UBE2E1)

Domains for UBE2E1 Gene

Gene Families for UBE2E1 Gene

Protein Domains for UBE2E1 Gene

Suggested Antigen Peptide Sequences for UBE2E1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51965

UniProtKB/Swiss-Prot:

UB2E1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2E1: view

Function for UBE2E1 Gene

Molecular function for UBE2E1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2E1 Gene

Gene Ontology (GO) - Molecular Function for UBE2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 16307923
GO:0005515 protein binding IPI 16307923
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2E1: view

Phenotypes for UBE2E1 Gene

GenomeRNAi human phenotypes for UBE2E1:
genes like me logo Genes that share phenotypes with UBE2E1: view

Animal Model Products

miRNA for UBE2E1 Gene

miRTarBase miRNAs that target UBE2E1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2E1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2E1 Gene

Localization for UBE2E1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2E1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2E1 Gene COMPARTMENTS Subcellular localization image for UBE2E1 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for UBE2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 15247280
GO:0005634 nucleus IDA 18845142
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBE2E1: view

Pathways for UBE2E1 Gene

SuperPathways for UBE2E1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 Class I MHC mediated antigen processing and presentation
3 Interferon Signaling
4 Inactivation of APC/C via direct inhibition of the APC/C complex
5 Cell Cycle, Mitotic
.62
genes like me logo Genes that share pathways with UBE2E1: view

Pathways by source for UBE2E1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitination (Ubiquitylation) Pathway in human,mouse,rat

UniProtKB/Swiss-Prot P51965-UB2E1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2E1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 15247280
GO:0000278 mitotic cell cycle TAS --
GO:0006511 ubiquitin-dependent protein catabolic process TAS 8576257
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with UBE2E1: view

Drugs for UBE2E1 Gene

(4) HMDB Compounds for UBE2E1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • Acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Novoseek inferred chemical compound relationships for UBE2E1 Gene

Compound -log(P) Hits PubMed IDs
cysteine 29.2 1
genes like me logo Genes that share compounds with UBE2E1: view

Transcripts for UBE2E1 Gene

Unigene Clusters for UBE2E1 Gene

Ubiquitin-conjugating enzyme E2E 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2E1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2E1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: - - -
SP9: - - -

Relevant External Links for UBE2E1 Gene

GeneLoc Exon Structure for
UBE2E1
ECgene alternative splicing isoforms for
UBE2E1

Expression for UBE2E1 Gene

mRNA expression in normal human tissues for UBE2E1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UBE2E1 Gene

This gene is overexpressed in Breast (45.4) and Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2E1 Gene

SOURCE GeneReport for Unigene cluster for UBE2E1 Gene Hs.164853

genes like me logo Genes that share expressions with UBE2E1: view

Expression partners for UBE2E1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2E1 Gene

Orthologs for UBE2E1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2E1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2E1 35
  • 92.75 (n)
  • 99.48 (a)
dog
(Canis familiaris)
Mammalia UBE2E1 35
  • 97.06 (n)
  • 100 (a)
UBE2E1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2e1 35
  • 91.02 (n)
  • 98.96 (a)
Ube2e1 16
Ube2e1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2E1 35
  • 100 (n)
  • 100 (a)
UBE2E1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2e1 35
  • 91.54 (n)
  • 98.96 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2E1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2E1 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2E1 35
  • 87.05 (n)
  • 99.48 (a)
UBE2E1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2E1 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75971 35
ube2e1 35
  • 83.13 (n)
  • 98.21 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2e1 35
  • 79.5 (n)
  • 91.38 (a)
ube2e2 36
  • 80 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4084 35
fruit fly
(Drosophila melanogaster)
Insecta CG10862 37
  • 51 (a)
CG2574 37
  • 47 (a)
CG5440 37
  • 70 (a)
UbcD2 37
  • 87 (a)
CG2574 36
  • 37 (a)
ManyToMany
CG5440 36
  • 64 (a)
ManyToMany
UbcD2 36
  • 64 (a)
ManyToMany
soybean
(Glycine max)
eudicotyledons Gma.1978 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6467 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6406 36
  • 71 (a)
OneToMany
Species with no ortholog for UBE2E1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2E1 Gene

ENSEMBL:
Gene Tree for UBE2E1 (if available)
TreeFam:
Gene Tree for UBE2E1 (if available)

Paralogs for UBE2E1 Gene

Paralogs for UBE2E1 Gene

genes like me logo Genes that share paralogs with UBE2E1: view

Variants for UBE2E1 Gene

Sequence variations from dbSNP and Humsavar for UBE2E1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs4025822 -- 23,883,689(+) GAGGC(A/G)GTCGG intron-variant
rs1986696 -- 23,884,914(+) TGTAT(C/T)GGTGT intron-variant
rs1967375 -- 23,832,435(+) AGCTC(A/G)GGAGT intron-variant
rs1966896 -- 23,817,439(+) AAAAA(A/G)AAAGA intron-variant
rs1966895 -- 23,817,243(+) tttga(C/G)accag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2E1 Gene

Variant ID Type Subtype PubMed ID
nsv834637 CNV Loss 17160897

Relevant External Links for UBE2E1 Gene

HapMap Linkage Disequilibrium report
UBE2E1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2E1 Gene

Disorders for UBE2E1 Gene

No disorders were found for UBE2E1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for UBE2E1 Gene

Publications for UBE2E1 Gene

  1. Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2- F1) and characterization of their interaction with E6-AP and RSP5. (PMID: 8576257) Nuber U. … Scheffner M. (J. Biol. Chem. 1996) 2 3 4
  2. Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. (PMID: 16428300) Takeuchi T. … Yokosawa H. (J. Biochem. 2005) 3 4
  3. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4
  4. Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. (PMID: 9990509) Anan T. … Nakao M. (Genes Cells 1998) 3 23
  5. Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes. (PMID: 10866800) Nyman T.A. … Kalkkinen N. (Eur. J. Biochem. 2000) 3 23

Products for UBE2E1 Gene

Sources for UBE2E1 Gene

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