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UBE2E1 Gene

protein-coding   GIFtS: 67
GCID: GC03P023847

Ubiquitin-Conjugating Enzyme E2E 1

(Previous names: ubiquitin-conjugating enzyme E2E 1 (homologous to yeast...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2E 11 2     Ubiquitin-Protein Ligase E12 3
UBCH62 3 5     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme E2E 1 (Homologous To Yeast UBC4/5)1 2     Ubiquitin-Conjugating Enzyme E2 E12
Ubiquitin-Conjugating Enzyme E2E 1 (UBC4/5 Homolog, Yeast)1 2     UbcH63
Ubiquitin Carrier Protein E12 3     

External Ids:    HGNC: 124771   Entrez Gene: 73242   Ensembl: ENSG000001701427   OMIM: 6029165   UniProtKB: P519653   

Export aliases for UBE2E1 gene to outside databases

Previous GC identifers: GC03M023441 GC03P023529 GC03P023697 GC03P023822 GC03P023793


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2E1 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced
transcript variants encoding distinct isoforms have been found for this gene. (provided by RefSeq, Jan 2011)

GeneCards Summary for UBE2E1 Gene:
UBE2E1 (ubiquitin-conjugating enzyme E2E 1) is a protein-coding gene. Diseases associated with UBE2E1 include limb-girdle muscular dystrophy type 2h, and limb-girdle muscular dystrophy. GO annotations related to this gene include ubiquitin-protein ligase activity and ISG15 ligase activity. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and
abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination

Gene Wiki entry for UBE2E1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2E1 gene promoter:
         STAT1   FOXD1   Pax-2   POU3F2 (N-Oct-5b)   Pax-2a   FOXL1   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2E1 promoter sequence
   Search Chromatin IP Primers for UBE2E1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2E1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.2   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24.2

UBE2E1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2E1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P023847:  view genomic region     (about GC identifiers)

Start:
23,847,384 bp from pter      End:
23,933,131 bp from pter
Size:
85,748 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 E1  
Size: 193 amino acids; 21404 Da
Subunit: Interacts with RNF14
3 PDB 3D structures from and Proteopedia for UBE2E1:
1XR9 (3D)        3BZH (3D)        4JJQ (3D)    
Secondary accessions: B2RBX4 C9J8K2 K4DI90
Alternative splicing: 3 isoforms:  P51965-1   P51965-2   P51965-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2E1: NX_P51965

Explore proteomics data for UBE2E1 at MOPED

Post-translational modifications: 

  • ISGylation suppresses ubiquitin E2 enzyme activity1
  • Ubiquitination2 at Lys136
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2E1 (P51965) (see all 6)
     YPFKPPK  ICLDILK  TNRAEHDR  SKVLLSICSLLTD 


    See UBE2E1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001189405.1  NP_003332.1  NP_872607.1  

    ENSEMBL proteins: 
     ENSP00000303709   ENSP00000329113   ENSP00000410652   ENSP00000475890   ENSP00000411351  
     ENSP00000393088  
    Reactome Protein details: P51965

    UBE2E1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for UBE2E1

    UBE2E1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for UBE2E1

    UBE2E1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for UBE2E1
    Cloud-Clone Corp. CLIAs for UBE2E1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry P51965

    ProtoNet protein and cluster: P51965

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2E1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2E1_HUMAN, P51965
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes
    the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and
    abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15247280
    GO:0005515protein binding IPI16307923
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
    GO:0042296ISG15 ligase activity IDA16428300
         
    UBE2E1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBE2E1:
     Synthetic lethal with Ras 

         1 MGI phenotypic allele for Ube2e1 (no phenotypes)

    UBE2E1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2E1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2E1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2E1

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2E1:
    hsa-mir-26b-5p (MIRT029169)

    Block miRNA regulation of human, mouse, rat UBE2E1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2E1 (see all 21):
    hsa-miR-495 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-181a-2* hsa-miR-105 hsa-miR-7-1* hsa-miR-542-3p hsa-miR-1183
    SwitchGear 3'UTR luciferase reporter plasmidUBE2E1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE2E1

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    GenScript: all cDNA clones in your preferred vector (see all 3): UBE2E1 (NM_003341)
    Sino Biological Human cDNA Clone for UBE2E1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2E1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UB2E1_HUMAN, P51965: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA15247280
    GO:0005634nucleus IDA18845142
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    UBE2E1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2E1 About   (see all 11)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42
    5Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2E1
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 GeneGo (Thomson Reuters) Pathway for UBE2E1
        Proteolysis Putative ubiquitin pathway


    Selected Reactome Pathways for UBE2E1 (see all 13)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    2 Kegg Pathways  (Kegg details for UBE2E1):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UB2E1_HUMAN, P51965
    Pathway: Protein modification; protein ubiquitination


    UBE2E1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2E1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2E1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2E1 (P519651, 2, 3 ENSP000003037094) via UniProtKB, MINT, STRING, and/or I2D (see all 230)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF5Q999422, 3, ENSP000003642354MINT-62577 MINT-62675 MINT-62751 I2D: score=5 STRING: ENSP00000364235
    ENSG00000183574Q999422, 3MINT-62577 MINT-62675 MINT-62751 I2D: score=5 
    ENSG00000223767Q999422, 3MINT-62577 MINT-62675 MINT-62751 I2D: score=5 
    ENSG00000225452Q999422, 3MINT-62577 MINT-62675 MINT-62751 I2D: score=5 
    ENSG00000227277Q999422, 3MINT-62577 MINT-62675 MINT-62751 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA15247280
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process TAS8576257
    GO:0007094mitotic spindle assembly checkpoint TAS--
    GO:0010390histone monoubiquitination IDA16307923

    UBE2E1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2E1 (UB2E1)

    4 HMDB Compounds for UBE2E1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 Novoseek inferred chemical compound relationship for UBE2E1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 29.2 1 9990509 (1)



    UBE2E1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBE2E1 gene (3 alternative transcripts): 
    NM_001202476.1  NM_003341.4  NM_182666.2  

    Unigene Cluster for UBE2E1:

    Ubiquitin-conjugating enzyme E2E 1
    Hs.164853  [show with all ESTs]
    Unigene Representative Sequence: NM_003341
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306627(uc003cch.3 uc003cci.3) ENST00000484048 ENST00000346855
    ENST00000495141 ENST00000481622 ENST00000442670 ENST00000467766(uc011awh.2)
    ENST00000424381(uc021wua.1) ENST00000475680 ENST00000452012 ENST00000493707


    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UBE2E1 (see all 21):
    hsa-miR-495 hsa-miR-1224-3p hsa-miR-1260b hsa-miR-181a-2* hsa-miR-105 hsa-miR-7-1* hsa-miR-542-3p hsa-miR-1183
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      QuantiTect SYBR Green Assays in human, mouse, rat UBE2E1
      QuantiFast Probe-based Assays in human, mouse, rat UBE2E1

    Additional mRNA sequence: 

    AK295354.1 AK314854.1 BC009139.1 X92963.1 

    12 DOTS entries:

    DT.318024  DT.95277632  DT.97765958  DT.91742794  DT.91742798  DT.95277631  DT.95303824  DT.120907446 
    DT.120907453  DT.120907492  DT.100796684  DT.75180231 

    Selected AceView cDNA sequences (see all 231):

    BM757766 BF969751 AI784674 AA356669 BG149911 AW439873 CR624061 BQ015123 
    CD106559 AI683088 BM090873 N22211 AI022520 AA889986 CF140057 BQ009648 
    CA412770 BM712095 BX470280 NM_182666 NM_003341 AI973239 BG928937 AA343829 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBE2E1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e
    SP1:        -     -           -           -     -           -                                 
    SP2:              -           -           -     -           -                                 
    SP3:                          -           -     -           -                                 
    SP4:                          -           -                 -                                 
    SP5:        -     -     -     -           -     -           -                                 


    ECgene alternative splicing isoforms for UBE2E1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2E1 expression in normal human tissues (normalized intensities)      UBE2E1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGAATGGC
    UBE2E1 Expression
    About this image


    UBE2E1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
    UBE2E1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2E1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.164853
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2E1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2E1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2e11 , 5 ubiquitin-conjugating enzyme E2E 1, UBC4/5 homolog more5
    ubiquitin-conjugating enzyme E2E 11
    91.02(n)1
    98.96(a)1
      14 (7.08 cM)5
    221941  NM_009455.31  NP_033481.11 
     182827225 
    chicken
    (Gallus gallus)
    Aves UBE2E11 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, more 87.05(n)
    99.48(a)
      420653  XM_004939408.1  XP_004939465.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2E16
    ubiquitin-conjugating enzyme E2E 1
    99(a)
    1 ↔ 1
    GL343357.1(682188-771153)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF284208.12   -- 81.99(n)    CF284208.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2e11 ubiquitin-conjugating enzyme E2E 1 79.5(n)
    91.38(a)
      563542  NM_001103116.1  NP_001096586.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta UbcD23 ubiquitin cycle ubiquitin conjugating
    enzyme
    87(a)
    (best of 4)
      2 32A5   --
    soybean
    (Glycine max)
    eudicotyledons Gma.19782 Transcribed sequence with weak similarity to protein more 77.49(n)  


    ENSEMBL Gene Tree for UBE2E1 (if available)
    TreeFam Gene Tree for UBE2E1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2E1 gene
    UBE2D32  UBE2L62  UBE2D12  UBE2D22  UBE2E32  UBE2D42  UBE2L32  UBE2E22  
    Selected SIMAP similar genes for UBE2E1 using alignment to 4 protein entries:     UB2E1_HUMAN (see all proteins) (see all similar genes):
    UBE2E3    UBE2D1    UBE2D3    UBE2E2    UBE2D2    UBE2D4
    HR6A    UBE2A    UBE2B    UBE2H    UBE2DNL    UBE2T
    UBE2N    UBE2W    UBE2G1    UBE2M    UBE2I    UBE2S

    UBE2E1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2E1 (see all 1795)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600783051,2
    C,F--23845853(+) TCCTGA/GAACCA 2 -- us2k12Minor allele frequency- G:0.10WA 120
    rs1855020251,2
    --23845913(+) TTTCAA/GTGGTG 2 -- us2k10--------
    rs1446107961,2
    --23845960(+) TATGAC/TCCTGA 2 -- us2k10--------
    rs1397599531,2
    --23846036(+) AGGGAC/TTGAGC 2 -- us2k10--------
    rs753567831,2
    C,F--23846107(+) AGAAGG/AAGTTC 2 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1453822571,2
    --23846110(+) AGGAGC/TTCGGC 2 -- us2k10--------
    rs556464511,2
    C,F--23846141(+) TTTCCT/AGGTTA 2 -- us2k12Minor allele frequency- A:0.11WA 120
    rs766545561,2
    C,F--23846199(+) AAGCCA/GCTGTT 2 -- us2k11Minor allele frequency- G:0.03NA 120
    rs613855011,2
    C,F--23846265(+) CTGAGG/CCTGTC 2 -- us2k12Minor allele frequency- C:0.04WA 120
    rs1907064881,2
    --23846360(+) AAAAGG/TTGAGA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2E1 (23847384 - 23933131 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2E1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834637CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBE2E1
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2E1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602916    OMIM disorders: --

    8 diseases for UBE2E1:    About MalaCards
    limb-girdle muscular dystrophy type 2h    limb-girdle muscular dystrophy    muscular dystrophy    muscular atrophy
    herpes simplex    parkinson's disease    hypoxia    malaria


    UBE2E1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for UBE2E1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2E1 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with UBE2E1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2- F1) and characterization of their interaction with E6-AP and RSP5. (PubMed id 8576257)1, 2, 3 Nuber U.... Scheffner M. (J. Biol. Chem. 1996)
    2. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. (PubMed id 18845142)1, 2 Espinosa A....Wahren-Herlenius M. (Exp. Cell Res. 2008)
    3. Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. (PubMed id 16428300)1, 2 Takeuchi T.... Yokosawa H. (J. Biochem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP- ribosylation factor domain protein 1). (PubMed id 15684077)1, 9 Vichi A.... Vaughan M. (Proc. Natl. Acad. Sci. U.S.A. 2005)
    6. N-terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. (PubMed id 11322894)1, 9 Ito K.... Okano Y. (Eur. J. Biochem. 2001)
    7. Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes. (PubMed id 10866800)1, 9 Nyman T.A....Kalkkinen N. (Eur. J. Biochem. 2000)
    8. Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. (PubMed id 9990509)1, 9 Anan T....Nakao M. (amp 1998)
    9. Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1. (PubMed id 23603909)1 Sarkari F....Sheng Y. (J. Biol. Chem. 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7324 HGNC: 12477 AceView: UBE2E1 Ensembl:ENSG00000170142 euGenes: HUgn7324
    ECgene: UBE2E1 Kegg: 7324 H-InvDB: UBE2E1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2E1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2E1 gene:
    Search GeneIP for patents involving UBE2E1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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