UBE2DNL Gene
pseudogene GIFtS: 29
GCID: GC0XP084197
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ubiquitin-conjugating enzyme E2D N-terminal like (pseudogene)(Previous names: ubiquitin-conjugating enzyme E2D N-terminal like, ubiquitin-conjugating...)
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Aliases
for UBE2DNL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
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| Ubiquitin-Conjugating Enzyme E2D N-Terminal Like (Pseudogene)1 2 | | UBE2D2L3 | | MGC426381 | | Ubiquitin Carrier Protein D2-Like3 | | Ubiquitin-Conjugating Enzyme E2D N-Terminal Like1 | | Ubiquitin-Conjugating Enzyme E2D N-Terminal-Like3 | | Ubiquitin-Conjugating Enzyme E2D N-Terminal Like Pseudogene1 | | Ubiquitin-Protein Ligase D2-Like3 |
| External Ids: | HGNC: 286561 | Entrez Gene: 1001318162 | Ensembl: ENSG000002295477 | UniProtKB: Q8IWF73 | | ORGUL members: | |
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| NONCODE:n406560 | |
Export aliases for UBE2DNL gene to outside databasesPrevious GC identifers: GC0XU900848 GC0XP084077 GC0XP084190 GC0XP084191 GC0XP084193 GC0XP084195
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Summaries
for UBE2DNL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
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-- |
Genomic Views
for UBE2DNL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2DNL gene promoter:
AhR POU2F1 AML1a POU2F1a Nkx2-5 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2DNL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2DNL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq21.1 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq21.1UBE2DNL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP084197: view genomic region
(about GC identifiers)
Start:
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84,189,157 bp from pter |
End:
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84,189,896 bp from pter |
Size:
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740 bases |
Orientation:
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plus strand |
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Proteins
for UBE2DNL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
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UniProtKB/Swiss-Prot: U2D2L_HUMAN, Q8IWF7 (See
protein sequence)Recommended Name: Putative ubiquitin-conjugating enzyme E2 D2-like protein Size: 75 amino acids; 8761 Da
Caution: Could be the product of a pseudogene. Probably inactive as a ubiquitin-conjugating enzyme since it lacks theessential active site cysteineExplore the universe of human proteins at neXtProt for UBE2DNL: NX_Q8IWF7
UBE2DNL Protein expression data from MOPED and PaxDb: About this image 
Human Recombinant Protein Products:
UBE2DNL Antibody Products:
Assay Products for UBE2DNL: |
Protein
Domains /
Families
for UBE2DNL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
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UBE2DNL for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IWF7ProtoNet protein and cluster: Q8IWF7 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: U2D2L_HUMAN, Q8IWF7Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function
for UBE2DNL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016881 | acid-amino acid ligase activity |
IEA | -- |
UBE2DNL for ontologies About GeneDecksing
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Pathways & Interactions
for UBE2DNL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBE2DNL
5/11 Interacting proteins for UBE2DNL (Q8IWF73) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
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Drugs & Compounds
for UBE2DNL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBE2DNL
Search CenterWatch for drugs/clinical trials and news about UBE2DNL 
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Transcripts
for UBE2DNL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
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REFSEQ mRNAs for UBE2DNL gene: NM_178567.2 Unigene Cluster for UBE2DNL: Ubiquitin-conjugating enzyme E2D N-terminal like (pseudogene) Hs.460809 [show with all ESTs]Unigene Representative Sequence: BG7179143 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000442533 ENST00000451386 ENST00000474922(uc011mqw.2)
Additional cDNA sequence: BC040290.1 NR_024062.1 1 DOTS entry: DT.40218494
GeneLoc Exon Structure
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Expression
for UBE2DNL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2DNL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATTTCAAA
About this image
See UBE2DNL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2DNL
SOURCE GeneReport for Unigene cluster: Hs.460809
SABiosciences Custom PCR Arrays for UBE2DNL
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat UBE2DNL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2DNL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2DNL |
Orthologs
for UBE2DNL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for UBE2DNL gene from 1 species (see representative species ) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ube2dnl15 |
ubiquitin-conjugating enzyme E2D N-terminal like |
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X (49.47 cM) 114905012 |
ENSEMBL Gene Tree for UBE2DNL (if available)
TreeFam Gene Tree for UBE2DNL (if available) |
Paralogs
for UBE2DNL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for UBE2DNL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for UBE2DNL (84189157 - 84189896 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBE2DNL: -- | SABiosciences Cancer Mutation PCR Assays |
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Disorders
/ Diseases
for UBE2DNL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
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Publications
for UBE2DNL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for UBE2DNL gene integrated from 9 sources:
(articles sorted by number of sources associating them with UBE2DNL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (2009)
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External Searches for UBE2DNL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing UBE2DNL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing UBE2DNL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBE2DNL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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About This Section
| Patent Information for UBE2DNL gene:
Search GeneIP for patents involving UBE2DNL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UBE2DNL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2DNL | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2DNL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2DNL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2DNL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2DNL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2DNL |
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| | | | Search Tocris compounds for UBE2DNL |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for UBE2DNL |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat UBE2DNL |
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GeneCards Homepage -
Last full update: 19 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013
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