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Aliases for UBE2D4 Gene

Aliases for UBE2D4 Gene

  • Ubiquitin Conjugating Enzyme E2 D4 (Putative) 2 3
  • Ubiquitin-Conjugating Enzyme E2D 4 (Putative) 2 3
  • Ubiquitin Conjugating Enzyme E2D 4 (Putative) 3 5
  • E2 Ubiquitin-Conjugating Enzyme D4 3 4
  • Ubiquitin Carrier Protein D4 3 4
  • Ubiquitin-Protein Ligase D4 3 4
  • HBUCE1 3 4
  • Ubiquitin-Conjugating Enzyme HBUCE1 3
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • UBCH5D 4

External Ids for UBE2D4 Gene

Previous GeneCards Identifiers for UBE2D4 Gene

  • GC07P043740
  • GC07P043932
  • GC07P043966

Summaries for UBE2D4 Gene

GeneCards Summary for UBE2D4 Gene

UBE2D4 (Ubiquitin Conjugating Enzyme E2 D4 (Putative)) is a Protein Coding gene. Among its related pathways are Immune System and p53 Pathway (RnD). GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2D4 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer Lys-11 and Lys-48-linked polyubiquitination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2D4 Gene

Genomics for UBE2D4 Gene

Regulatory Elements for UBE2D4 Gene

Promoters for UBE2D4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2D4 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2D4 Gene

Chromosome:
7
Start:
43,926,436 bp from pter
End:
43,956,136 bp from pter
Size:
29,701 bases
Orientation:
Plus strand

Genomic View for UBE2D4 Gene

Genes around UBE2D4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2D4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2D4 Gene

Proteins for UBE2D4 Gene

  • Protein details for UBE2D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y2X8-UB2D4_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D4
    Protein Accession:
    Q9Y2X8
    Secondary Accessions:
    • A4D1V0

    Protein attributes for UBE2D4 Gene

    Size:
    147 amino acids
    Molecular mass:
    16649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBE2D4 Gene

Proteomics data for UBE2D4 Gene at MOPED

Post-translational modifications for UBE2D4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for UBE2D4 Gene

Gene Families for UBE2D4 Gene

Protein Domains for UBE2D4 Gene

Suggested Antigen Peptide Sequences for UBE2D4 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y2X8

UniProtKB/Swiss-Prot:

UB2D4_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2D4: view

Function for UBE2D4 Gene

Molecular function for UBE2D4 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer Lys-11 and Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2D4 Gene

Gene Ontology (GO) - Molecular Function for UBE2D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBE2D4: view
genes like me logo Genes that share phenotypes with UBE2D4: view

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2D4 Gene

Localization for UBE2D4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2D4 Gene COMPARTMENTS Subcellular localization image for UBE2D4 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBE2D4 Gene

Pathways & Interactions for UBE2D4 Gene

genes like me logo Genes that share pathways with UBE2D4: view

UniProtKB/Swiss-Prot Q9Y2X8-UB2D4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IDA 21685362
GO:0035519 protein K29-linked ubiquitination IDA 20061386
GO:0070979 protein K11-linked ubiquitination IDA 20061386
GO:0085020 protein K6-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2D4: view

No data available for SIGNOR curated interactions for UBE2D4 Gene

Drugs & Compounds for UBE2D4 Gene

(3) Drugs for UBE2D4 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2D4 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2D4: view

Transcripts for UBE2D4 Gene

Unigene Clusters for UBE2D4 Gene

Ubiquitin-conjugating enzyme E2D 4 (putative):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - -

Relevant External Links for UBE2D4 Gene

GeneLoc Exon Structure for
UBE2D4
ECgene alternative splicing isoforms for
UBE2D4

Expression for UBE2D4 Gene

mRNA expression in normal human tissues for UBE2D4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2D4 Gene

This gene is overexpressed in Muscle - Skeletal (x6.2).

Protein differential expression in normal tissues from HIPED for UBE2D4 Gene

This gene is overexpressed in Heart (51.0) and Brain (16.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2D4 Gene



SOURCE GeneReport for Unigene cluster for UBE2D4 Gene Hs.19196

genes like me logo Genes that share expression patterns with UBE2D4: view

Protein tissue co-expression partners for UBE2D4 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for UBE2D4 Gene

Orthologs for UBE2D4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2D4 35
  • 90.8 (n)
  • 99.25 (a)
UBE2D4 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2d2b 35
  • 76.19 (n)
  • 87.07 (a)
Ube2d2b 16
Ube2d4 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2d4 35
  • 77.1 (n)
  • 87.07 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2D4 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2D4 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497147 35
  • 82.54 (n)
  • 97.96 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2d4 35
  • 82.09 (n)
  • 99.32 (a)
ube2d4 36
  • 99 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F52C6.12 36
  • 71 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC11 35
  • 69.84 (n)
  • 79.59 (a)
rice
(Oryza sativa)
Liliopsida Os01g0819400 35
  • 69.84 (n)
  • 79.59 (a)
Species with no ortholog for UBE2D4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2D4 Gene

ENSEMBL:
Gene Tree for UBE2D4 (if available)
TreeFam:
Gene Tree for UBE2D4 (if available)

Paralogs for UBE2D4 Gene

genes like me logo Genes that share paralogs with UBE2D4: view

Variants for UBE2D4 Gene

Sequence variations from dbSNP and Humsavar for UBE2D4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs725840 -- 43,939,353(-) GAACA(A/G)GCAGT intron-variant
rs1181499 -- 43,931,274(-) ttttt(G/T)gtaga intron-variant
rs1181500 -- 43,931,267(-) tagag(A/C)tgggg intron-variant
rs1181501 -- 43,931,177(-) ttaca(A/G)gcatg intron-variant
rs1181503 -- 43,938,678(+) taaaa(A/G)tacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2D4 Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv830980 CNV Loss 17160897
dgv2079e1 CNV Complex 17122850

Variation tolerance for UBE2D4 Gene

Residual Variation Intolerance Score: 41.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2D4 Gene

HapMap Linkage Disequilibrium report
UBE2D4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2D4 Gene

Disorders for UBE2D4 Gene

Relevant External Links for UBE2D4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2D4

No disorders were found for UBE2D4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2D4 Gene

Publications for UBE2D4 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 2 3 4 67
  2. Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. (PMID: 25527291) Wauer T. … Komander D. (EMBO J. 2015) 3
  3. The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes. (PMID: 24211586) Uhler J.P. … Gustafsson C.M. (Biochem. Biophys. Res. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Ube2W conjugates ubiquitin to I+-amino groups of protein N-termini. (PMID: 23560854) Tatham M.H. … Hay R.T. (Biochem. J. 2013) 3

Products for UBE2D4 Gene

Sources for UBE2D4 Gene

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