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Aliases for UBE2D4 Gene

Aliases for UBE2D4 Gene

  • Ubiquitin-Conjugating Enzyme E2D 4 (Putative) 2 3
  • Ubiquitin Carrier Protein D4 3 4
  • Ubiquitin-Protein Ligase D4 3 4
  • EC 4 63
  • HBUCE1 3 4
  • Ubiquitin-Conjugating Enzyme HBUCE1 3
  • Ubiquitin-Conjugating Enzyme E2 D4 3
  • UBCH5D 4

External Ids for UBE2D4 Gene

Previous GeneCards Identifiers for UBE2D4 Gene

  • GC07P043740
  • GC07P043932
  • GC07P043966

Summaries for UBE2D4 Gene

GeneCards Summary for UBE2D4 Gene

UBE2D4 (Ubiquitin-Conjugating Enzyme E2D 4 (Putative)) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2D4 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer Lys-11 and Lys-48-linked polyubiquitination.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2D4 Gene

Genomics for UBE2D4 Gene

Regulatory Elements for UBE2D4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2D4 Gene

43,926,134 bp from pter
43,956,136 bp from pter
30,003 bases
Plus strand

Genomic View for UBE2D4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2D4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2D4 Gene

Proteins for UBE2D4 Gene

  • Protein details for UBE2D4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D4
    Protein Accession:
    Secondary Accessions:
    • A4D1V0

    Protein attributes for UBE2D4 Gene

    147 amino acids
    Molecular mass:
    16649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBE2D4 Gene

Proteomics data for UBE2D4 Gene at MOPED

Post-translational modifications for UBE2D4 Gene

  • Ubiquitination at Lys144
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2D4 Gene

Antibody Products

Domains for UBE2D4 Gene

Gene Families for UBE2D4 Gene

  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2D4 Gene

Suggested Antigen Peptide Sequences for UBE2D4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9Y2X8
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2D4: view

Function for UBE2D4 Gene

Molecular function for UBE2D4 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer Lys-11 and Lys-48-linked polyubiquitination.

Enzyme Numbers (IUBMB) for UBE2D4 Gene

Gene Ontology (GO) - Molecular Function for UBE2D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 20061386
GO:0005515 protein binding IPI 15231748
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2D4: view

Phenotypes for UBE2D4 Gene

GenomeRNAi human phenotypes for UBE2D4:
genes like me logo Genes that share phenotypes with UBE2D4: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for UBE2D4 Gene

Localization for UBE2D4 Gene

Subcellular locations from

Jensen Localization Image for UBE2D4 Gene COMPARTMENTS Subcellular localization image for UBE2D4 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBE2D4 Gene

Pathways for UBE2D4 Gene

genes like me logo Genes that share pathways with UBE2D4: view

UniProtKB/Swiss-Prot Q9Y2X8-UB2D4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2D4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0016567 protein ubiquitination IDA 21685362
GO:0035519 protein K29-linked ubiquitination IDA 20061386
GO:0044314 protein K27-linked ubiquitination IDA 20061386
GO:0070534 protein K63-linked ubiquitination IDA 20061386
genes like me logo Genes that share ontologies with UBE2D4: view

Compounds for UBE2D4 Gene

(4) HMDB Compounds for UBE2D4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
Phosphoric acid
  • acide phosphorique (FRENCH)
  • (4-)Diphosphoric acid ion
genes like me logo Genes that share compounds with UBE2D4: view

Transcripts for UBE2D4 Gene

Unigene Clusters for UBE2D4 Gene

Ubiquitin-conjugating enzyme E2D 4 (putative):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2D4

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D4 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b · 8c · 8d · 8e
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: - -

Relevant External Links for UBE2D4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBE2D4 Gene

mRNA expression in normal human tissues for UBE2D4 Gene

mRNA differential expression in normal tissues according to GTEx for UBE2D4 Gene

This gene is overexpressed in Muscle - Skeletal (6.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2D4 Gene

SOURCE GeneReport for Unigene cluster for UBE2D4 Gene Hs.19196

genes like me logo Genes that share expressions with UBE2D4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UBE2D4 Gene

Orthologs for UBE2D4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 95 (a)
(Bos Taurus)
Mammalia UBE2D4 35
  • 90.8 (n)
  • 99.25 (a)
UBE2D4 36
  • 89 (a)
(Mus musculus)
Mammalia Ube2d2b 35
  • 76.19 (n)
  • 87.07 (a)
Ube2d4 36
  • 91 (a)
Ube2dnl2 16
(Monodelphis domestica)
Mammalia UBE2D4 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia UBE2D4 36
  • 77 (a)
(Rattus norvegicus)
Mammalia Ube2d4 35
  • 77.1 (n)
  • 87.07 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497147 35
  • 82.54 (n)
  • 97.96 (a)
(Danio rerio)
Actinopterygii ube2d4 35
  • 82.09 (n)
  • 99.32 (a)
ube2d4 36
  • 99 (a)
(Caenorhabditis elegans)
Secernentea F52C6.12 36
  • 71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC11 35
  • 69.84 (n)
  • 79.59 (a)
(Oryza sativa)
Liliopsida Os01g0819400 35
  • 69.84 (n)
  • 79.59 (a)
Species with no ortholog for UBE2D4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2D4 Gene

Gene Tree for UBE2D4 (if available)
Gene Tree for UBE2D4 (if available)

Paralogs for UBE2D4 Gene

Paralogs for UBE2D4 Gene

genes like me logo Genes that share paralogs with UBE2D4: view

Variants for UBE2D4 Gene

Sequence variations from dbSNP and Humsavar for UBE2D4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs725840 -- 43,939,353(-) GAACA(A/G)GCAGT intron-variant
rs1045398 -- 43,952,827(+) ACCCA(C/G)TCTCT utr-variant-3-prime, intron-variant
rs1181499 -- 43,931,274(-) ttttt(G/T)gtaga intron-variant
rs1181500 -- 43,931,267(-) tagag(A/C)tgggg intron-variant
rs1181501 -- 43,931,177(-) ttaca(A/G)gcatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2D4 Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv830980 CNV Loss 17160897
dgv2079e1 CNV Complex 17122850

Relevant External Links for UBE2D4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2D4 Gene

Disorders for UBE2D4 Gene

No disorders were found for UBE2D4 Gene.

No data available for UniProtKB/Swiss-Prot for UBE2D4 Gene

Publications for UBE2D4 Gene

  1. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. (PMID: 20061386) David Y. … Navon A. (J. Biol. Chem. 2010) 3 4
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for UBE2D4 Gene

Sources for UBE2D4 Gene

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