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UBE2D3 Gene

protein-coding GIFtS: 63

GC04M103936

ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
(Previous name: ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E2(17)KB3 ^²
EC 6.3.2.19 ^³
MGC43926 ^²
MGC5416 ^²
OTTHUMP00000161758 ^²
OTTHUMP00000161759 ^²
UBC4/5 ^²
UBCH5C ^², ³
UbcH5C ^¹

Descriptions
E2(17)KB 3 ^³
Ubiquitin carrier protein D3 ^³
Ubiquitin-conjugating enzyme E2-17 kDa 3 ^², ³
Ubiquitin-protein ligase D3 ^³
ubiquitin carrier protein ^²
ubiquitin-conjugating enzyme E2D 3 ^²
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) ^²
ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5) ^¹, ²

External Ids
HGNC: 12476¹
Entrez Gene: 7323²
UniProtKB: P61077³
Ensembl: ENSG00000109332⁷

Search outside databases for aliases for UBE2D3 gene

Previous GC identifers: GC04M104116 GC04M104026 GC04M104175 GC04M104074

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2D3:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53,

which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been

found for this gene, but the full-length nature of some variants has not been determined.

[provided by RefSeq]

UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination

of p53/TP53

Gene Wiki entry for UBE2D3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2D3 gene

Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24

UBE2D3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04M103936: (about GC identifiers)

Start:	103,936,217 bp from pter
End:	104,009,473 bp from pter
Size:	73,257 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000004.10 NT_016354.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 D3

Size: 147 amino acids; 16687 Da

PDB structure from and Proteopedia :

1X23 (3D)

2FUH (3D)

Secondary accessions: A6NM99 P47986 Q6IB88 Q6NXS4

REFSEQ proteins (9 alternative transcripts):

NP_003331.1 NP_871615.1 NP_871616.1 NP_871617.1 NP_871618.1 NP_871619.1 NP_871620.1 NP_871621.1

NP_871622.1

ENSEMBL proteins:

ENSP00000337262 ENSP00000378282 ENSP00000318494 ENSP00000378283 ENSP00000337208 ENSP00000378280

ENSP00000344069 ENSP00000349722 ENSP00000378277 ENSP00000345285

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBE2D3 Protein
	Sigma-Aldrich Proteins for UBE2D3
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2D3
	Recombinant Proteins from Abcam (UBE2D3)
	Human Recombinant Proteins from Abnova (UBE2D3)

OriGene Purified Recombinant Human Proteins (see all 2): UBE2D3

Antibodies for UBE2D3:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of UBE2D3
	Sigma-Aldrich Antibodies for UBE2D3
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE2D3), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2D3)
	Novus Biologicals Antibodies for UBE2D3

Assays for UBE2D3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2D3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61077

ProtoNet protein and cluster: P61077

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2D3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2D3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 9): NM_181889

Applied Biosystems Silencer® siRNAs for UBE2D3

Sigma-Aldrich siRNA and siRNA Panels for UBE2D3

Sigma-Aldrich shRNA Panels and shRNA for UBE2D3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2D3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 9): NM_003340
Myc/DDK tagged cDNA clones in CMV expression vector (see all 9): NM_003340
untagged cDNA clones in CMV expression vector (see all 10): AK095822

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_181893

UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination

of p53/TP53

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	8090726
GO:0005515	protein binding	IPI	14667819
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2D3 (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway
Hypoxia Signaling in the Cardiovascular System

GeneDecks UBE2D3 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2D3

4 Interacting proteins for UBE2D3 (ENSP00000344069³ P61077^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000183574	Q99942¹^,²	EBI-348268, EBI-348482 MINT-62678 MINT-62754 MINT-62580
ENSG00000206254	Q99942¹^,²	EBI-348268, EBI-348482 MINT-62678 MINT-62754 MINT-62580
RNF5	Q99942¹^,²	EBI-348268, EBI-348482 MINT-62678 MINT-62754 MINT-62580 EBI-348268, EBI-348482 MINT-62678 MINT-62754 MINT-62580
RNF5	Q99942¹^,²	EBI-348268, EBI-348482 MINT-62678 MINT-62754 MINT-62580 EBI-348268, EBI-348482 MINT-62678 MINT-62754 MINT-62580
--	ensp: ENSP00000318494³	STRING (score=)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	8530467
GO:0016567	protein ubiquitination	IDA	9990509
GO:0030509	BMP signaling pathway	EXP	15621726
GO:0051246	regulation of protein metabolic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2D3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2D3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2D3)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 9): NM_181889

Sigma-Aldrich siRNA and siRNA Panels for UBE2D3

Sigma-Aldrich shRNA Panels and shRNA for UBE2D3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003340 NM_181886 NM_181887 NM_181888 NM_181889 NM_181890 NM_181891 NM_181892

NM_181893

REFSEQ mRNAs for UBE2D3 gene (9 alternative transcripts):

NM_003340.4 NM_181886.1 NM_181887.1 NM_181888.1 NM_181889.1 NM_181890.1 NM_181891.1 NM_181892.1

NM_181893.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003340 NM_181886 NM_181887 NM_181888 NM_181889 NM_181890 NM_181891 NM_181892

NM_181893

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 9): NM_003340
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 9): NM_003340
                                 untagged cDNA clones in CMV expression vector (see all 10): AK095822

Additional cDNA sequence:

AK095822.1 AK124159.1 AK127304.1 AK315775.1 AL050186.1 AL833414.1 BC003395.1 BC037894.2

BC066917.1 CR456916.1 CR596812.1 CR604221.1 CR608063.1 CR610934.1 CR619029.1 CR620503.1

CR625720.1 U39318.1

24/69 DOTS entries (see all 69 ):

DT.100684091 DT.100805383 DT.101969497 DT.101985597 DT.454162 DT.95273708 DT.97780980 DT.100684103

DT.101985592 DT.97862577 DT.100039445 DT.100684107 DT.121253183 DT.95092051 DT.91788058 DT.100684106

DT.91700781 DT.100684101 DT.121253022 DT.121253182 DT.121253306 DT.100684097 DT.95273714 DT.95273713

24/782 AceView cDNA sequences (see all 782 ):

BU186980 CB162571 BU193254 BU677041 W46934 CR619029 CR618043 AA164993

NM_181888 AI923982 BM541512 AW874003 AL535270 CA427172 AL050186 BX427697

AW196905 CR604221 BQ007163 CA444507 BF432055 F11733 BU192219 CB409969

highest scoring ESTs for UBE2D3:

AW020027 U39318 AV754305 BF215733 BF666811 BG613555 BM465843 BU570661 CD642889 AA017200

Unigene Cluster for UBE2D3:

Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)

Hs.518773 [show with all ESTs]

Unigene Representative Sequence: AK127304

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D3 (see all 9 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	^	6	^	7	^	8	^	9	^	10	^	11
SP1:							-		-		-		-		-		-
SP2:											-		-		-		-
SP3:															-		-
SP4:
SP5:					-		-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for UBE2D3

10 Ensembl transcripts including schematic representations:

ENST00000350435 ENST00000394803 ENST00000321805 ENST00000394804 ENST00000338145 ENST00000394801

ENST00000349311 ENST00000357194 ENST00000394798 ENST00000343106

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2D3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2D3

¹ / ² / ³

13 probe-sets matching UBE2D3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
91086_at²^{, 3}	U95-E	1	1.00	1.00	0.76	1.13	AW020027	0.80	1.00	0.91	1
60027_r_at²^{, 3}	U95-C	1	1.00	1.00	0.44	0.13	N58386	0.60	1.00	0.82	1
504_at²^{, 3}	U95-A	2	1.00	0.91	0.93	0.83	U39318	0.80	1.00	0.91	1
75179_at²^{, 3}	U95-D	1	0.75	1.00	0.85	1.12	R81146	0.60	1.00	0.82	1
39083_at²^{, 3}	U95-A	1	0.56	1.00	0.73	0.92	U39318	0.80	1.00	0.91	1
240383_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI239832	0.40	1.00	0.76	1
200668_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003395	0.60	1.00	0.82	1
200667_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF448062	0.60	1.00	0.82	1
200669_s_at²^{, 3}	U133-A	2	1.00	0.73	--	--	NM_003340	0.60	1.00	0.82	1
240383_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200668_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200667_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
200669_s_at²	U133Plus2	2	1.00	0.73	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AATGAATAAA

SOURCE GeneReport for Unigene cluster: Hs.518773
Expression variation in blood from EXPOLDB for UBE2D3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2D3 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	UBE2D3¹	--	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, more	99.55(n) 98.64(a)	461941 XM_517826.2 XP_517826.2
cow (Bos taurus)	LOC781309¹	--	similar to Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 more	97.73(n) 95.92(a)	781309 XM_001249440.1 XP_001249441.1
rat (Rattus norvegicus)	Ube2d3¹	--	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, more	98.41(n) 100(a)	81920 NM_031237.1 NP_112516.1
mouse (Mus musculus)	Ube2d3^{1, 5}	3⁵	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, more^{1, 5}	98.41(n)¹ 100(a)¹	66105¹ NM_025356.3¹ NP_079632.1¹ AA414951⁵ AI450581⁵ (see all 47)
zebrafish (Danio rerio)	wufj13d01²	--	wufj13d01	85.26(n)	335444 BC059548.1

About this table Species with no ortholog for UBE2D3

ENSEMBL Gene Tree for UBE2D3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2D3 gene

UBE2D1² UBE2D4² UBE2D2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/379 NCBI SNPs in UBE2D3 are shown (see all 379 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 130)

AB	SNP ID	Valid	Chr 4 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs223383^1,2	A,C,F,H,O	103970389(+)	`CTTACA/GTTTCT`	3	--	int¹ ng3¹		8		MN EU EA WA NA	720
	rs223390^1,2	A,C,F,H,O	103967932(+)	`GCACAG/AGACCG`	9	--	int¹ ng3¹ ut5¹		6		NA EU EA	438
	rs223391^1,2	A,C,F,H	103967359(+)	`AGGAAG/AGAAAT`	9	--	int¹ ut5¹ trp³		8		EU EA WA	824
	rs223387^1,2	A,C,F,O	103968654(+)	`TTATGG/CTGTGG`	9	--	int¹ ng3¹		5		NA MN EA	496
	rs223388^1,2	A,C,F,O	103968582(+)	`GCTCGA/GGCCGG`	9	--	ng3¹ int¹		5		NA MN EA	498
	rs223385^1,2	C,F,H	103969454(+)	`aaaatA/Gcgact`	8	--	int¹ ng3¹		4		EU EA WA	410
--	rs223384^1,2	A,C,F	103970271(+)	`ATCCAA/TGCTTA`	3	--	int¹ ng3¹		3		NA	120
	rs13117052^1,2	C,F,H	103968885(+)	`CGTCCG/CCCAAG`	9	--	ng3¹ int¹		8		EU EA WA	830
	rs223389^1,2	C,F	103968081(+)	`GAGGAG/AGATCA`	9	--	int¹ ng3¹ ut5¹ trp³		5		MN EA NA	1820
--	rs223386^1,2	C	103969406(+)	`cagtgC/Tttctc`	9	--	ng3¹ int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for UBE2D3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602963

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/28 PubMed articles for UBE2D3 gene (see all 28 ):

Identification of a family of closely related human ubiquitin conjugating enzymes. (PubMed id 8530467)^{2, 3, 4} Jensen J.P....Weissman A.M. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. (PubMed id 9990509)^{1, 3} Anan T....Nakao M. (1998)
Physical and functional interactions between ZIP kinase and UbcH5. (PubMed id 18515077)³ Ohbayashi N....Matsuda T. (2008)
RNAi screen identifies UBE2D3 as a mediator of all-trans retinoic acid-induced cell growth arrest in human acute promyelocytic NB4 cells. (PubMed id 17420285)³ Hattori H....Luo H.R. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)³ Stelzl U....Wanker E.E. (2005)
Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)³ Rual J.F....Vidal M. (2005)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)⁴ Hillier L.W....Wilson R.K. (2005)
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. (PubMed id 14667819)³ Lehner B....Sanderson C.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7323	HGNC: 12476	AceView: UBE2D3	Ensembl:ENSG00000109332	euGenes: HUgn7323
ECgene: UBE2D3	H-InvDB: UBE2D3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for UBE2D3	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE2D3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBE2D3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2D3-related products

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Antibodies for UBE2D3

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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UBE2D3 Gene at Home site.
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UBE2D3 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for UBE2D3

Summaries
for UBE2D3

Genomic Location
for UBE2D3

Proteins
for UBE2D3

Protein Domains/
Families
for UBE2D3

Gene Function
for UBE2D3

Pathways & Interactions
for UBE2D3

Drugs & Compounds
for UBE2D3

Transcripts
for UBE2D3

Expression
for UBE2D3

Orthologs
for UBE2D3

Paralogs
for UBE2D3

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Disorders & Mutations
for UBE2D3

Medical News
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for UBE2D3

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Genome Databases showing UBE2D3

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2D3 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor UBE2D3

Summariesfor UBE2D3

Genomic Locationfor UBE2D3

Proteinsfor UBE2D3

Protein Domains/Familiesfor UBE2D3

Gene Functionfor UBE2D3

Pathways & Interactionsfor UBE2D3

Drugs & Compoundsfor UBE2D3

Transcriptsfor UBE2D3

Expression for UBE2D3

Orthologsfor UBE2D3

Paralogsfor UBE2D3

SNPs/Variantsfor UBE2D3

Disorders & Mutationsfor UBE2D3

Medical Newsfor UBE2D3

Publicationsfor UBE2D3

Search for UBE2D3

Genome Databases showing UBE2D3

Other Databases showing UBE2D3

Specialized Databases showing UBE2D3

Licensable Technologiesfor UBE2D3

Servicesfor UBE2D3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2D3

Summaries
for UBE2D3

Genomic Location
for UBE2D3

Proteins
for UBE2D3

Protein Domains/
Families
for UBE2D3

Gene Function
for UBE2D3

Pathways & Interactions
for UBE2D3

Drugs & Compounds
for UBE2D3

Transcripts
for UBE2D3

Expression
for UBE2D3

Orthologs
for UBE2D3

Paralogs
for UBE2D3

SNPs/Variants
for UBE2D3

Disorders & Mutations
for UBE2D3

Medical News
for UBE2D3

Publications
for UBE2D3

Licensable Technologies
for UBE2D3

Services
for UBE2D3