Aliases for UBE2D3 Gene
- Ubiquitin-Conjugating Enzyme E2D 3 2 3
- Ubiquitin-Conjugating Enzyme E2D 3 (Homologous To Yeast UBC4/5) 2 3
- Ubiquitin-Conjugating Enzyme E2D 3 (UBC4/5 Homolog, Yeast) 2 3
- Ubiquitin-Conjugating Enzyme E2-17 KDa 3 3 4
- Ubiquitin-Conjugating Enzyme E2(17)KB 3 3 4
- Ubiquitin Carrier Protein D3 3 4
- Ubiquitin-Protein Ligase D3 3 4
- EC 126.96.36.199 4 63
External Ids for UBE2D3 Gene
Previous GeneCards Identifiers for UBE2D3 Gene
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for UBE2D3 Gene
UBE2D3 (Ubiquitin-Conjugating Enzyme E2D 3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2L6.
UniProtKB/Swiss-Prot for UBE2D3 Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11-, as well as Lys-48-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions Lys-21 and/or Lys-22 with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction (By similarity).