UBE2D3 Gene
protein-coding GIFtS: 65
GCID: GC04M103717
|
|
ubiquitin-conjugating enzyme E2D 3(Previous names: ubiquitin-conjugating enzyme E2D 3 (homologous to yeast...)
| |
Aliases
for UBE2D3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2D 31 2 | | EC 6.3.2.193 8 | | Ubiquitin-Conjugating Enzyme E2D 3 (Homologous To Yeast UBC4/5)1 2 | | UbcH5C1 | | Ubiquitin-Conjugating Enzyme E2D 3 (UBC4/5 Homolog, Yeast)1 2 | | E2(17)KB32 | | Ubiquitin Carrier Protein D32 3 | | UBC4/52 | | Ubiquitin-Conjugating Enzyme E2(17)KB 32 3 | | E2(17)KB 32 | | Ubiquitin-Conjugating Enzyme E2-17 KDa 32 3 | | Ubiquitin-Conjugating Enzyme E2 D32 | | Ubiquitin-Protein Ligase D32 3 | | UBC5C3 | | UBCH5C2 3 | | |
Export aliases for UBE2D3 gene to outside databasesPrevious GC identifers: GC04M104116 GC04M104026 GC04M104175 GC04M104074 GC04M103936 GC04M099453 |
Summaries
for UBE2D3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2D3:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, orE1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of theE2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor proteinp53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for thisgene, but the full-length nature of some variants has not been determined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11)E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as aninitiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin.Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linkedubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination ofPCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT)pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with theBRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading toDNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB)formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53.Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunctionwith the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during itsinternalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinatesunfolded proteins to catalyze their immediate destruction (By similarity)
Gene Wiki entry for UBE2D3
|
Genomic Views
for UBE2D3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2D3 gene promoter:
p53
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2D3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2D3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24UBE2D3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M103717: view genomic region
(about GC identifiers)
Start:
|
103,715,540 bp from pter |
End:
|
103,790,053 bp from pter |
Size:
|
74,514 bases |
Orientation:
|
minus strand |
|
Proteins
for UBE2D3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 D3 Size: 147 amino acids; 16687 Da
Subunit: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, theinteraction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the DNAdamage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently withubiquitin
Subcellular location: Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein
5 PDB 3D structures from  and Proteopedia  for UBE2D3:1X23 (3D)
2FUH (3D)
3L1Z (3D)
3RPG (3D)
3UGB (3D)
Secondary accessions: A6NJ93 A6NJB1 A6NM99 P47986 Q6IB88 Q6NXS4 Q8N924Alternative splicing: 3 isoforms: P61077-1 P61077-2 P61077-3 Explore the universe of human proteins at neXtProt for UBE2D3: NX_P61077
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P61077
4/11 DME Specific Peptides for UBE2D3 (P61077) (see all 11)
UBE2D3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (9 alternative transcripts):
NP_003331.1 NP_871615.1 NP_871616.1 NP_871617.1 NP_871618.1 NP_871619.1 NP_871620.1 NP_871621.1 NP_871622.1
ENSEMBL proteins: ENSP00000396901 ENSP00000378280 ENSP00000378282 ENSP00000345285 ENSP00000318494 ENSP00000337262 ENSP00000337208 ENSP00000344069 ENSP00000426620 ENSP00000349722 ENSP00000426586 ENSP00000424359 ENSP00000421904 ENSP00000427270 ENSP00000422939 ENSP00000422134 ENSP00000424710 ENSP00000421794 ENSP00000423487 ENSP00000423692 ENSP00000423324 ENSP00000425762 ENSP00000423869 ENSP00000421310 ENSP00000378283 Reactome Protein details: P61077
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
UBE2D3 for ontologies About GeneDecksing
UBE2D3 Antibody Products:
Assay Products for UBE2D3: |
Protein
Domains /
Families
for UBE2D3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2D3 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P61077ProtoNet protein and cluster: P61077 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function
for UBE2D3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11)E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as aninitiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin.Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-linkedubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination ofPCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT)pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with theBRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading toDNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML-NB)formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53.Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunctionwith the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during itsinternalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinatesunfolded proteins to catalyze their immediate destruction (By similarity)Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.191 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D3 (see all 12)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D3 (see all 9)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 9): UBE2D3 (NM_003340) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2D3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UBE2D3 for ontologies About GeneDecksing
|
Pathways & Interactions
for UBE2D3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha | | | 3 | Antigen processing: Ubiquitination & Proteasome degradation | | | 4 | Immune System | | | 5 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for UBE2D3
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2D3
1 
Cell Signaling Technology (CST) Pathway for UBE2D3
5/7  BioSystems Pathways for UBE2D3 (see all 7)
5/31 
Reactome Pathways for UBE2D3 (see all 31)
2 
Kegg Pathways (Kegg details for UBE2D3):
UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077Pathway: Protein modification; protein ubiquitination
UBE2D3 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2D3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/160 Interacting proteins for UBE2D3 (P610771, 2, 3 ENSP000003497224) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RNF5 | Q999421, 2, 3, ENSP000003642354 | EBI-2809412,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D:
score=5 STRING: ENSP00000364235 | | OTUB1 | Q96FW12, 3 | MINT-8388587 MINT-8388689 MINT-8388575 I2D:
score=1 | | KIAA1107 | Q9UPP52, 3, ENSP000003594044 | MINT-8276086 I2D:
score=2 STRING: ENSP00000359404 | | STK25 | O005062, 3, ENSP000003257484 | MINT-8276163 I2D:
score=2 STRING: ENSP00000325748 | | UBA52 | P629872, 3, ENSP000003881074 | MINT-8276185 I2D:
score=2 STRING: ENSP00000388107 |
About this table
Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
TAS | -- | | GO:0000209 | protein polyubiquitination |
IDA | 14765125 | | GO:0006281 | DNA repair |
IEA | -- | | GO:0006351 | transcription, DNA-dependent |
TAS | -- | | GO:0006367 | transcription initiation from RNA polymerase II promoter |
TAS | -- |
UBE2D3 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2D3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBE2D3
4 HMDB Compounds for UBE2D3 About this table
Search CenterWatch for drugs/clinical trials and news about UBE2D3 / UB2D3
|
Transcripts
for UBE2D3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE2D3 gene (9 alternative transcripts): NM_003340.5 NM_181886.2 NM_181887.1 NM_181888.2 NM_181889.1 NM_181890.1 NM_181891.1 NM_181892.2 NM_181893.1 Unigene Cluster for UBE2D3: Ubiquitin-conjugating enzyme E2D 3 Hs.518773 [show with all ESTs]Unigene Representative Sequence: AK12730418/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32): ENST00000453744(uc003hwl.3) ENST00000394801(uc011ceu.2 uc003hwo.3)
ENST00000394803(uc003hwp.3 uc003hwq.3 uc003hwr.3) ENST00000508474
ENST00000343106(uc003hwi.3) ENST00000503742 ENST00000321805 ENST00000350435
ENST00000338145 ENST00000349311 ENST00000504211 ENST00000505009 ENST00000357194
ENST00000505207 ENST00000507845 ENST00000502404 ENST00000508635 ENST00000505307
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D3 (see all 12)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D3 (see all 9)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 9): UBE2D3 (NM_003340) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2D3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D3 |
Additional cDNA sequence: AK095822.1 AK124159.1 AK127304.1 AK315775.1 AL050186.1 AL833414.1 BC003395.1 BC037894.2 BC066917.1 CR456916.1 U39318.1 24/69 DOTS entries (see all 69): DT.100684091 DT.100805383 DT.101969497 DT.101985597 DT.454162 DT.95273708 DT.97780980 DT.100684103 DT.97862577 DT.101985592 DT.100039445 DT.100684107 DT.121253183 DT.95092051 DT.91788058 DT.91700781 DT.100684106 DT.100684101 DT.121253022 DT.121253182 DT.121253306 DT.100684097 DT.95273714 DT.95273713 24/782 AceView cDNA sequences (see all 782): AA814363 AI969964 BM549140 AW469128 BP340476 AW874003 AW673579 AU137729 BE466287 AA812699 W65385 AI500469 BM718817 AA194976 CD677028 BF594116 N57390 CR625720 NM_181886 BM848626 AA159801 BQ921533 BM667502 AA593876
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D3 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for UBE2D3
|
Expression
for UBE2D3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2D3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGAATAAA
About this image
See UBE2D3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2D3
SOURCE GeneReport for Unigene cluster: Hs.518773
SABiosciences Expression via Pathway-Focused PCR Array including UBE2D3:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2D3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2D3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2D3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2D3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D3 |
Orthologs
for UBE2D3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2D3 gene from 7/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
UBE2D31 |
ubiquitin-conjugating enzyme E2D 3 |
90.48(n)
97.96(a) |
|
422713 NM_001031153.1 NP_001026324.1 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.200942 |
Xenopus laevis transcribed sequence with strong similarity more |
89.34(n) |
|
CD254673.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufj13d012 |
wufj13d01 |
85.26(n) |
|
335444 BC059548.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
eff3 |
ubiquitin cycle ubiquitin conjugating enzyme |
93(a)
(best of 3) |
|
3 88D2 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
let-703 |
ubiquitin-conjugating enzyme E2-17 KD |
92(a) |
|
IV(11081633-11082511) -- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBC301 |
ubiquitin-conjugating enzyme E2 30 |
68.48(n)
80.95(a) |
|
835714 NM_124997.3 NP_568835.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.114792 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
74.44(n) |
|
NM_191104.1 |
ENSEMBL Gene Tree for UBE2D3 (if available)
TreeFam Gene Tree for UBE2D3 (if available) |
Paralogs
for UBE2D3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE2D3 gene
- ENSG000002586772 UBE2L62 UBE2D12 UBE2D22 UBE2W2 UBE2E32 UBE2D42 UBE2E12
- UBE2E22 UBE2L32
18/30 SIMAP similar genes for UBE2D3 using alignment to 11 protein entries: UB2D3_HUMAN (see all proteins)
(see all similar genes):UBE2D2 UBE2D4 UBE2D1 UBE2E3 HR6A UBE2E1
UBE2DNL UBE2A UBE2E2 UBE2B UBE2L3 UBE2H
UBE2K UBE2N UBE2G2 UBE2M UBE2NL UBE2G1
UBE2D3 for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for UBE2D3 (see all 7)
PGOHUM00000248651 PGOHUM00000247780 PGOHUM00000247141 PGOHUM00000251136 PGOHUM00000237994
|
Genomic Variants
for UBE2D3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for UBE2D3
3 CNVs: 3505 63909 32625 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2D3 |
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Disorders
/ Diseases
for UBE2D3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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|
UBE2D3 for disorders About GeneDecksing
OMIM gene information: 602963
OMIM disorders: --
15  diseases for UBE2D3: About MalaCardslimb-girdle muscular dystrophy type 2h limb-girdle muscular dystrophy dna topoisomerase ii muscular dystrophy
oxyphilic adenoma orofacial cleft alcohol dependence gigantism
conjunctivitis adenoma alcoholism breast cancer
malaria leukemia hypoxia
Human Genome Epidemiology (HuGE) Navigator: UBE2D3 (2 documents)
Export disorders for UBE2D3 gene to outside databases
|
Publications
for UBE2D3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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|
PubMed articles for UBE2D3 gene, integrated from 9 sources (see all 176):
(articles sorted by number of sources associating them with UBE2D3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a family of closely related human ubiquitin conjugating enzymes. (PubMed id 8530467)1, 2, 3 Jensen J.P.... Weissman A.M. (1995)
- Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. (PubMed id 15247280)1, 2, 9 Rajendra R.... Rubin E.H. (2004)
- Priming and extending: a UbcH5/Cdc34 E2 handoff mecha nism for polyubiquitination on a SCF substrate. (PubMed id 20347421)1, 2 Wu K....Pan Z.Q. (2010)
- PCNA is ubiquitinated by RNF8. (PubMed id 18948756)1, 2 Zhang S.... Lee M.Y.W.T. (2008)
- Physical and functional interactions between ZIP kinase and UbcH5. (PubMed id 18515077)1, 2 Ohbayashi N....Matsuda T. (2008)
- Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. (PubMed id 18851830)1, 2 Saha A. and Deshaies R.J. (2008)
- A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. (PubMed id 16628214)1, 2 Polanowska J....Boulton S.J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. (PubMed id 15280377)1, 2 Saville M.K....Lane D.P. (2004)
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External Searches for UBE2D3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing UBE2D3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
|
Other Databases showing UBE2D3 gene
(According to HUGE)
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| -- |
Specialized Databases showing UBE2D3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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|
|
About This Section
| Patent Information for UBE2D3 gene:
Search GeneIP for patents involving UBE2D3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for UBE2D3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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|
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