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UBE2D3 Gene

protein-coding   GIFtS: 67
GCID: GC04M103717

Ubiquitin-Conjugating Enzyme E2D 3

(Previous names: ubiquitin-conjugating enzyme E2D 3 (homologous to yeast...)
  Search for UBE2D3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2D 31 2     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme E2D 3 (Homologous To Yeast UBC4/5)1 2     E2(17)KB32
Ubiquitin-Conjugating Enzyme E2D 3 (UBC4/5 Homolog, Yeast)1 2     PRO21162
Ubiquitin Carrier Protein D32 3     UBC4/52
Ubiquitin-Conjugating Enzyme E2(17)KB 32 3     E2(17)KB 32
Ubiquitin-Conjugating Enzyme E2-17 KDa 32 3     Ubiquitin-Conjugating Enzyme E2 D32
Ubiquitin-Protein Ligase D32 3     UBC5C3
UBCH5C2 3     

External Ids:    HGNC: 124761   Entrez Gene: 73232   Ensembl: ENSG000001093327   OMIM: 6029635   UniProtKB: P610773   

Export aliases for UBE2D3 gene to outside databases

Previous GC identifers: GC04M104116 GC04M104026 GC04M104175 GC04M104074 GC04M103936 GC04M099453


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2D3 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the
ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple
spliced transcript variants have been found for this gene, but the full-length nature of some variants has not
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2D3 Gene:
UBE2D3 (ubiquitin-conjugating enzyme E2D 3) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the
SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal
degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or
'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains
from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the
priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the
operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical
agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage
sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences
promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and
TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation
of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for
polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In
conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their
immediate destruction (By similarity)

Gene Wiki entry for UBE2D3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2D3 gene promoter:
         p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UBE2D3 promoter sequence
   Search Chromatin IP Primers for UBE2D3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2D3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

UBE2D3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2D3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M103717:  view genomic region     (about GC identifiers)

Start:
103,715,540 bp from pter      End:
103,790,053 bp from pter
Size:
74,514 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 D3  
Size: 147 amino acids; 16687 Da
Subunit: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the
interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the
DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with
ubiquitin. Interacts with E3 ubiquitin-protein ligase CBLC
6 PDB 3D structures from and Proteopedia for UBE2D3:
1X23 (3D)        2FUH (3D)        3L1Z (3D)        3RPG (3D)        3UGB (3D)        4BVU (3D)    
Secondary accessions: A6NJ93 A6NJB1 A6NM99 P47986 Q6IB88 Q6NXS4 Q8N924
Alternative splicing: 3 isoforms:  P61077-1   P61077-2   P61077-3   

Explore the universe of human proteins at neXtProt for UBE2D3: NX_P61077

Explore proteomics data for UBE2D3 at MOPED

Post-translational modifications: 

  • Phosphorylated by AURKB (By similarity)1
  • Ubiquitination2 at Lys8, Lys144
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2D3 (P61077) (see all 11)
     CSAGPVG  YPFKPPK  PLVPEIA  QWSPALT 


    See UBE2D3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (9 alternative transcripts): 
    NP_003331.1  NP_871615.1  NP_871616.1  NP_871617.1  NP_871618.1  NP_871619.1  NP_871620.1  NP_871621.1  
    NP_871622.1  

    ENSEMBL proteins: 
     ENSP00000396901   ENSP00000378280   ENSP00000378282   ENSP00000345285   ENSP00000318494  
     ENSP00000337262   ENSP00000337208   ENSP00000344069   ENSP00000426620   ENSP00000349722  
     ENSP00000426586   ENSP00000424359   ENSP00000421904   ENSP00000427270   ENSP00000422939  
     ENSP00000422134   ENSP00000424710   ENSP00000421794   ENSP00000423487   ENSP00000423692  
     ENSP00000423324   ENSP00000425762   ENSP00000423869   ENSP00000421310   ENSP00000378283  
    Reactome Protein details: P61077

    UBE2D3 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant UBE2D3 Protein
    R&D Systems Recombinant & Natural Proteins for UBE2D3 (UbcH5c/UBE2D3)
    Enzo Life Sciences proteins for UBE2D3
    OriGene Purified Proteins for UBE2D3
    OriGene Protein Over-expression Lysate for UBE2D3
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    OriGene Custom Protein Services for UBE2D3
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    Novus Biologicals UBE2D3 Proteins
    Novus Biologicals UBE2D3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBE2D3
    Cloud-Clone Corp. Proteins for UBE2D3

     
    Search eBioscience for Proteins for UBE2D3 

    UBE2D3 Antibody Products:

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    Novus Biologicals UBE2D3 Antibodies
    Abcam antibodies for UBE2D3
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    LSBio Antibodies in human, mouse, rat for UBE2D3

    UBE2D3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for UBE2D3
    Cloud-Clone Corp. CLIAs for UBE2D3
    Search eBioscience for ELISAs for UBE2D3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry P61077

    ProtoNet protein and cluster: P61077

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    Find genes that share domains with UBE2D3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2D3_HUMAN, P61077
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the
    SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal
    degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or
    'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains
    from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the
    priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the
    operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical
    agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage
    sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences
    promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and
    TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation
    of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for
    polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In
    conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their
    immediate destruction (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14765125
    GO:0005515protein binding IPI14667819
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with UBE2D3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2D3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2D3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2D3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2D3

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2D3:
    hsa-mir-423-5p (MIRT038113), hsa-let-7b-5p (MIRT032304), hsa-mir-155-5p (MIRT020637), hsa-mir-101-3p (MIRT027292), hsa-mir-877-3p (MIRT037185), hsa-mir-98-5p (MIRT027590)

    Block miRNA regulation of human, mouse, rat UBE2D3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2D3 (see all 84):
    hsa-miR-549 hsa-miR-1321 hsa-miR-605 hsa-miR-30d hsa-miR-4275 hsa-miR-4267 hsa-miR-30a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidUBE2D3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UBE2D3
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2D3

    Gene Editing
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 9): UBE2D3 (NM_003340)
    Sino Biological Human cDNA Clone for UBE2D3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2D3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D3
    Addgene plasmids for UBE2D3 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UB2D3_HUMAN, P61077: Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytosol4
    nucleus4
    extracellular1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0010008endosome membrane IEA--

    Find genes that share ontologies with UBE2D3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2D3 About   (see all 22)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Signaling by BMP
    Signaling by BMP0.35
    BMP Signalling Pathway0.00
    3Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    4Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen1.00
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha0.00
    Cellular response to hypoxia1.00
    5Toll Like Receptor 7/8 (TLR7/8) Cascade
    MyD88-independent cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69


    Find genes that share SuperPaths with UBE2D3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2D3
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for UBE2D3
        Protein Stability

    Selected BioSystems Pathways for UBE2D3 (see all 7)
        TGF-beta Receptor Signaling Pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway
    BMP Signalling Pathway
    BARD1 signaling events


    Selected Reactome Pathways for UBE2D3 (see all 6)
        IKK complex recruitment mediated by RIP1
    Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
    Antigen processing: Ubiquitination & Proteasome degradation
    Downregulation of SMAD2/3:SMAD4 transcriptional activity
    Negative regulators of RIG-I/MDA5 signaling


    2 Kegg Pathways  (Kegg details for UBE2D3):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2D3: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2D3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2D3 (P610771, 2, 3 ENSP000003497224) via UniProtKB, MINT, STRING, and/or I2D (see all 252)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF5Q999421, 2, 3, ENSP000003642354EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 STRING: ENSP00000364235
    ENSG00000183574Q999421, 2, 3EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 
    ENSG00000223767Q999421, 2, 3EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 
    ENSG00000225452Q999421, 2, 3EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 
    ENSG00000227277Q999421, 2, 3EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0000209protein polyubiquitination IDA14765125
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006281DNA repair IEA--

    Find genes that share ontologies with UBE2D3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2D3 (UB2D3)

    4 HMDB Compounds for UBE2D3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBE2D3 gene (9 alternative transcripts): 
    NM_003340.6  NM_181886.3  NM_181887.2  NM_181888.3  NM_181889.2  NM_181890.2  NM_181891.2  NM_181892.3  
    NM_181893.2  

    Unigene Cluster for UBE2D3:

    Ubiquitin-conjugating enzyme E2D 3
    Hs.518773  [show with all ESTs]
    Unigene Representative Sequence: AK127304
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000453744(uc003hwl.3) ENST00000394801(uc011ceu.2 uc003hwo.3)
    ENST00000394803(uc003hwp.3 uc003hwq.3 uc003hwr.3) ENST00000508474
    ENST00000343106(uc003hwi.3) ENST00000503742 ENST00000321805 ENST00000350435
    ENST00000338145 ENST00000349311 ENST00000504211 ENST00000505009 ENST00000357194
    ENST00000505207 ENST00000507845 ENST00000502404 ENST00000508635 ENST00000505307

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate UBE2D3 (see all 84):
    hsa-miR-549 hsa-miR-1321 hsa-miR-605 hsa-miR-30d hsa-miR-4275 hsa-miR-4267 hsa-miR-30a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidUBE2D3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE2D3
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    Additional mRNA sequence: 

    AK095822.1 AK124159.1 AK127304.1 AK315775.1 AL050186.1 AL833414.1 BC003395.1 BC037894.2 
    BC066917.1 CR456916.1 U39318.1 

    Selected DOTS entries (see all 69):

    DT.100684091  DT.100805383  DT.101969497  DT.101985597  DT.454162  DT.97780980  DT.95273708  DT.100684103 
    DT.97862577  DT.101985592  DT.100039445  DT.100684107  DT.121253183  DT.91788058  DT.95092051  DT.100684106 
    DT.91700781  DT.100684101  DT.121253022  DT.121253182  DT.121253306  DT.100684097  DT.95273714  DT.95273713 

    Selected AceView cDNA sequences (see all 782):

    AI684027 AA814363 CA398122 AA812699 CB112961 AW469128 BQ083508 CR603201 
    CR620503 BU199079 AW196905 W77937 CR604221 BM841572 AI357090 CB529377 
    AW673579 BX427697 NM_181887 AW772341 CA445717 CD242548 CB240781 BP375695 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D3 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -     -     -     -     -     -                                                         
    SP2:                                -     -     -     -                                                         
    SP3:                                            -     -                                                         
    SP4:                                                                                                            
    SP5:              -     -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for UBE2D3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    UBE2D3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAATAAA
    UBE2D3 Expression
    About this image

    UBE2D3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2D3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.518773
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2D3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2D3 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2d31 , 5 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, more5
    ubiquitin-conjugating enzyme E2D 31
    98.41(n)1
    100(a)1
      3 (62.56 cM)5
    661051  NM_025356.41  NP_079632.11 
     1354387595 
    chicken
    (Gallus gallus)
    Aves UBE2D31 ubiquitin-conjugating enzyme E2D 3 93.42(n)
    100(a)
      422713  NM_001031153.1  NP_001026324.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.200942 Xenopus laevis transcribed sequence with strong similarity more 89.34(n)    CD254673.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj13d012 wufj13d01 85.26(n)   335444  BC059548.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eff3 ubiquitin cycle ubiquitin conjugating
    enzyme
    93(a)
    (best of 3)
      3 88D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea let-703 ubiquitin-conjugating enzyme E2-17 KD 92(a)   IV(11081633-11082511)   --
    soybean
    (Glycine max)
    eudicotyledons Gma.132482 Transcribed sequence with strong similarity to protein more 77.26(n)  
    rice
    (Oryza sativa)
    Liliopsida Os.114792 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.44(n)    NM_191104.1 


    ENSEMBL Gene Tree for UBE2D3 (if available)
    TreeFam Gene Tree for UBE2D3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2D3 gene
    UBE2L62  UBE2D12  UBE2D22  UBE2E32  UBE2D42  UBE2L32  UBE2E12  UBE2E22  
    Selected SIMAP similar genes for UBE2D3 using alignment to 11 protein entries:     UB2D3_HUMAN (see all proteins) (see all similar genes):
    UBE2D2    UBE2D1    UBE2D4    UBE2E3    UBE2E1    HR6A
    UBE2DNL    UBE2A    UBE2E2    UBE2B    UBE2M    UBE2H
    UBE2K    UBE2L3    UBE2N    UBE2G2    UBE2NL    UBE2G1

    Find genes that share paralogs with UBE2D3           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for UBE2D3 (see all 7)
    PGOHUM00000248651 PGOHUM00000247780 PGOHUM00000247141 PGOHUM00000251136 PGOHUM00000237994


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2D3 (see all 1452)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753837561,2
    --99467213(+) ACAAGC/TGAGTC 9 -- int11Minor allele frequency- T:0.50CSA 2
    rs1836569671,2
    --103716645(+) TGCAGC/TATGAC 9 -- ds5001 int10--------
    rs1458215421,2
    --103716780(+) CAGAAC/GGCATG 9 -- ds5001 int10--------
    rs1477734431,2
    --103716853(+) AAATGC/TTTATA 9 -- ds5001 int10--------
    rs1892026661,2
    --103716880(+) ATTTAC/TTTCTA 9 -- ds5001 int10--------
    rs1154463251,2
    C,F--103716967(+) AGTCAC/TAGATG 9 -- ds5001 int11Minor allele frequency- T:0.03WA 118
    rs99422581,2
    C,F--103717014(+) CAAAAT/CAAACA 9 -- ds5001 int11Minor allele frequency- C:0.05WA 118
    rs1410863891,2
    --103717058(+) AAAGGC/TGAAGA 9 -- ds5001 int10--------
    rs1819598111,2
    --103717180(+) AAATGA/GTATCT 9 -- ut310--------
    rs753535211,2
    C--103717376(+) ACAAGA/GTGAAG 9 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2D3 (103715540 - 103790053 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for UBE2D3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv965e199CNV Deletion23128226
    esv2672686CNV Deletion23128226
    esv2675680CNV Deletion23128226
    esv2728080CNV Deletion23290073
    esv23610CNV Loss19812545
    nsv10541CNV Loss18304495
    nsv879683CNV Loss21882294
    nsv526256CNV Loss19592680
    dgv1655e1CNV Complex17122850
    dgv1656e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602963    OMIM disorders: --


    Find genes that share disorders with UBE2D3           About GenesLikeMe

    Genetic Association Database (GAD): UBE2D3
    Human Genome Epidemiology (HuGE) Navigator: UBE2D3 (2 documents)

    Export disorders for UBE2D3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2D3 gene, integrated from 10 sources (see all 211):
    (articles sorted by number of sources associating them with UBE2D3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of closely related human ubiquitin conjugating enzymes. (PubMed id 8530467)1, 2, 3 Jensen J.P.... Weissman A.M. (J. Biol. Chem. 1995)
    2. Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. (PubMed id 15247280)1, 2, 9 Rajendra R.... Rubin E.H. (J. Biol. Chem. 2004)
    3. Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate. (PubMed id 20347421)1, 2 Wu K.... Pan Z.Q. (Mol. Cell 2010)
    4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)
    5. PCNA is ubiquitinated by RNF8. (PubMed id 18948756)1, 2 Zhang S.... Lee M.Y.W.T. (Cell Cycle 2008)
    6. Physical and functional interactions between ZIP kinase and UbcH5. (PubMed id 18515077)1, 2 Ohbayashi N.... Matsuda T. (Biochem. Biophys. Res. Commun. 2008)
    7. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. (PubMed id 18851830)1, 2 Saha A. and Deshaies R.J. (Mol. Cell 2008)
    8. A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. (PubMed id 16628214)1, 2 Polanowska J....Boulton S.J. (EMBO J. 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7323 HGNC: 12476 AceView: UBE2D3 Ensembl:ENSG00000109332 euGenes: HUgn7323
    ECgene: UBE2D3 Kegg: 7323 H-InvDB: UBE2D3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UBE2D3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2D3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2D3 gene:
    Search GeneIP for patents involving UBE2D3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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