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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2D3 Gene

protein-coding   GIFtS: 66
GCID: GC04M103717

Ubiquitin-Conjugating Enzyme E2D 3

(Previous names: ubiquitin-conjugating enzyme E2D 3 (homologous to yeast...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2D 31 2     EC 6.3.2.193 8
Ubiquitin-Conjugating Enzyme E2D 3 (Homologous To Yeast UBC4/5)1 2     E2(17)KB32
Ubiquitin-Conjugating Enzyme E2D 3 (UBC4/5 Homolog, Yeast)1 2     PRO21162
Ubiquitin Carrier Protein D32 3     UBC4/52
Ubiquitin-Conjugating Enzyme E2(17)KB 32 3     E2(17)KB 32
Ubiquitin-Conjugating Enzyme E2-17 KDa 32 3     Ubiquitin-Conjugating Enzyme E2 D32
Ubiquitin-Protein Ligase D32 3     UBC5C3
UBCH5C2 3     

External Ids:    HGNC: 124761   Entrez Gene: 73232   Ensembl: ENSG000001093327   OMIM: 6029635   UniProtKB: P610773   

Export aliases for UBE2D3 gene to outside databases

Previous GC identifers: GC04M104116 GC04M104026 GC04M104175 GC04M104074 GC04M103936 GC04M099453


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2D3 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the
ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple
spliced transcript variants have been found for this gene, but the full-length nature of some variants has not
been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBE2D3 Gene: 
UBE2D3 (ubiquitin-conjugating enzyme E2D 3) is a protein-coding gene. Diseases associated with UBE2D3 include limb-girdle muscular dystrophy type 2h, and oxyphilic adenoma, and among its related super-pathways are Antigen processing: Ubiquitination & Proteasome degradation and Toll-Like Receptors Cascades. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the
SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal
degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or
'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains
from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the
priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the
operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical
agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage
sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences
promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and
TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation
of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for
polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In
conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their
immediate destruction (By similarity)

Gene Wiki entry for UBE2D3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2D3 gene promoter:
         p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UBE2D3 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2D3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2D3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24

UBE2D3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2D3 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M103717:  view genomic region     (about GC identifiers)

Start:
103,715,540 bp from pter      End:
103,790,053 bp from pter
Size:
74,514 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 D3  
Size: 147 amino acids; 16687 Da
Subunit: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex; when Cullin is neddylated, the
interaction between the E2 and the SCF complex is strengthened. Interacts with DAPK3. Interacts with BRCA1; the
DNA damage checkpoint promotes the association with BRCA1 after ionizing radiation. Interacts non-covalently with
ubiquitin
Subcellular location: Cell membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein
5 PDB 3D structures from and Proteopedia for UBE2D3:
1X23 (3D)        2FUH (3D)        3L1Z (3D)        3RPG (3D)        3UGB (3D)    
Secondary accessions: A6NJ93 A6NJB1 A6NM99 P47986 Q6IB88 Q6NXS4 Q8N924
Alternative splicing: 3 isoforms:  P61077-1   P61077-2   P61077-3   

Explore the universe of human proteins at neXtProt for UBE2D3: NX_P61077

Explore proteomics data for UBE2D3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P61077

  • 4/11 DME Specific Peptides for UBE2D3 (P61077) (see all 11)
     CSAGPVG  YPFKPPK  PLVPEIA  QWSPALT 

    UBE2D3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2D3 Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_003331.1  NP_871615.1  NP_871616.1  NP_871617.1  NP_871618.1  NP_871619.1  NP_871620.1  NP_871621.1  
    NP_871622.1  

    ENSEMBL proteins: 
     ENSP00000396901   ENSP00000378280   ENSP00000378282   ENSP00000345285   ENSP00000318494  
     ENSP00000337262   ENSP00000337208   ENSP00000344069   ENSP00000426620   ENSP00000349722  
     ENSP00000426586   ENSP00000424359   ENSP00000421904   ENSP00000427270   ENSP00000422939  
     ENSP00000422134   ENSP00000424710   ENSP00000421794   ENSP00000423487   ENSP00000423692  
     ENSP00000423324   ENSP00000425762   ENSP00000423869   ENSP00000421310   ENSP00000378283  
    Reactome Protein details: P61077
    Human Recombinant Protein Products for UBE2D3: 
    EMD Millipore Purified and/or Recombinant UBE2D3 Protein
    R&D Systems Recombinant & Natural Proteins for UBE2D3 (UbcH5c/UBE2D3)
    Enzo Life Sciences proteins for UBE2D3
    OriGene Purified Proteins for UBE2D3
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    Novus Biologicals UBE2D3 Proteins
    Novus Biologicals UBE2D3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UBE2D3
    Cloud-Clone Corp. Proteins for UBE2D3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane IEA--
    GO:0010008endosome membrane IEA--

    UBE2D3 for ontologies           About GeneDecksing



    UBE2D3 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for UBE2D3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P61077

    ProtoNet protein and cluster: P61077

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2D3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2D3_HUMAN, P61077
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the
    SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal
    degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or
    'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains
    from the UBE2D3-primed NFKBIA-linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the
    priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the
    operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical
    agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage
    sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences
    promyelocytic leukemia protein nuclear body (PML-NB) formation in the nucleus. In conjunction with the MDM2 and
    TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation
    of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for
    polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In
    conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their
    immediate destruction (By similarity)
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14765125
    GO:0005515protein binding IPI14667819
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2D3 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2D3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBE2D3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2D3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2D3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2D3
    8/84 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2D3 (see all 84):
    hsa-miR-549 hsa-miR-1321 hsa-miR-605 hsa-miR-30d hsa-miR-4275 hsa-miR-4267 hsa-miR-30a hsa-miR-3622b-3p
    SwitchGear 3'UTR luciferase reporter plasmidUBE2D3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBE2D3
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 9): UBE2D3 (NM_003340)
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                         Customized lentivirus expression plasmids for stable overexpression of UBE2D3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2D3 About   (see all 24)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    2TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86
    3Immune System
    Immune System0.90
    Negative regulators of RIG-I/MDA5 signaling0.78
    Innate Immune System0.90
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.78
    4Cellular response to hypoxia
    Cellular response to hypoxia0.72
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha0.72
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen0.72
    Cellular responses to stress0.72
    5Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer0.63
    Downregulation of SMAD2/3:SMAD4 transcriptional activity0.56
    Signaling by TGF-beta Receptor Complex0.61

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for UBE2D3
        Selected targets of Oct-3/4
    Common schema of ubiquitination

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2D3
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    1 Cell Signaling Technology (CST) Pathway for UBE2D3
        Protein Stability

    5/7 BioSystems Pathways for UBE2D3 (see all 7)
        TGF-beta Receptor Signaling Pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway
    BMP Signalling Pathway
    Canonical NF-kappaB pathway

    5/29        Reactome Pathways for UBE2D3 (see all 29)
        IKK complex recruitment mediated by RIP1
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Innate Immune System
    Toll-Like Receptors Cascades


    2         Kegg Pathways  (Kegg details for UBE2D3):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UB2D3_HUMAN, P61077
    Pathway: Protein modification; protein ubiquitination


    UBE2D3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2D3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/188 Interacting proteins for UBE2D3 (P610771, 2, 3 ENSP000003497224) via UniProtKB, MINT, STRING, and/or I2D (see all 188)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF5Q999421, 2, 3, ENSP000003642354EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 STRING: ENSP00000364235
    ENSG00000183574Q999421, 2, 3EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 
    ENSG00000223767Q999421, 2, 3EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 
    ENSG00000225452Q999421, 2, 3EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 
    ENSG00000227277Q999421, 2, 3EBI-348268,EBI-348482 MINT-62678 MINT-62754 MINT-62580 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0000209protein polyubiquitination IDA14765125
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006281DNA repair IEA--

    UBE2D3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2D3 (UB2D3)

    4 HMDB Compounds for UBE2D3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about UBE2D3 / UB2D3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2D3 gene (9 alternative transcripts): 
    NM_003340.6  NM_181886.3  NM_181887.2  NM_181888.3  NM_181889.2  NM_181890.2  NM_181891.2  NM_181892.3  
    NM_181893.2  

    Unigene Cluster for UBE2D3:

    Ubiquitin-conjugating enzyme E2D 3
    Hs.518773  [show with all ESTs]
    Unigene Representative Sequence: AK127304
    18/32 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 32):
    ENST00000453744(uc003hwl.3) ENST00000394801(uc011ceu.2 uc003hwo.3)
    ENST00000394803(uc003hwp.3 uc003hwq.3 uc003hwr.3) ENST00000508474
    ENST00000343106(uc003hwi.3) ENST00000503742 ENST00000321805 ENST00000350435
    ENST00000338145 ENST00000349311 ENST00000504211 ENST00000505009 ENST00000357194
    ENST00000505207 ENST00000507845 ENST00000502404 ENST00000508635 ENST00000505307


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    Additional mRNA sequence: 

    AK095822.1 AK124159.1 AK127304.1 AK315775.1 AL050186.1 AL833414.1 BC003395.1 BC037894.2 
    BC066917.1 CR456916.1 U39318.1 

    24/69 DOTS entries (see all 69):

    DT.100684091  DT.100805383  DT.101969497  DT.101985597  DT.454162  DT.97780980  DT.95273708  DT.100684103 
    DT.97862577  DT.101985592  DT.100039445  DT.100684107  DT.121253183  DT.91788058  DT.95092051  DT.100684106 
    DT.91700781  DT.100684101  DT.121253022  DT.121253182  DT.121253306  DT.100684097  DT.95273714  DT.95273713 

    24/782 AceView cDNA sequences (see all 782):

    CR620503 CA444507 CA427172 BP375695 AW960018 AU139652 AI524425 BM667502 
    AA465553 BP379357 AI378591 AA446976 W46934 CB240781 AA806808 BU192219 
    AW511968 AI923427 CB129321 W65385 AW469128 BQ771681 BQ219366 AU139659 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D3 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                    -     -     -     -     -     -                                                         
    SP2:                                -     -     -     -                                                         
    SP3:                                            -     -                                                         
    SP4:                                                                                                            
    SP5:              -     -     -     -     -     -     -                                                         


    ECgene alternative splicing isoforms for UBE2D3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2D3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAATAAA
    UBE2D3 Expression
    About this image


    See UBE2D3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2D3

    SOURCE GeneReport for Unigene cluster: Hs.518773
        SABiosciences Expression via Pathway-Focused PCR Array including UBE2D3: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2D3 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2d31 , 5 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, more5
    ubiquitin-conjugating enzyme E2D 31
    95.46(n)1
    97.96(a)1
      3 (62.56 cM)5
    661051  NM_025356.41  NP_079632.11 
     1354387595 
    chicken
    (Gallus gallus)
    Aves UBE2D31 ubiquitin-conjugating enzyme E2D 3 90.48(n)
    97.96(a)
      422713  NM_001031153.1  NP_001026324.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.200942 Xenopus laevis transcribed sequence with strong similarity more 89.34(n)    CD254673.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj13d012 wufj13d01 85.26(n)   335444  BC059548.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eff3 ubiquitin cycle ubiquitin conjugating
    enzyme
    93(a)
    (best of 3)
      3 88D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea let-703 ubiquitin-conjugating enzyme E2-17 KD 92(a)   IV(11081633-11082511)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC5(YDR059C)4 Ubiquitin-conjugating enzyme that mediates selective more   --   4(569770-569234) 851631  NP_010344.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC301 ubiquitin-conjugating enzyme E2 30 68.48(n)
    80.95(a)
      835714  NM_124997.3  NP_568835.1 
    rice
    (Oryza sativa)
    Liliopsida Os.114792 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.44(n)    NM_191104.1 


    ENSEMBL Gene Tree for UBE2D3 (if available)
    TreeFam Gene Tree for UBE2D3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2D3 gene
    UBE2L62  UBE2D12  UBE2D22  UBE2E32  UBE2D42  UBE2L32  UBE2E12  UBE2E22  
    18/30 SIMAP similar genes for UBE2D3 using alignment to 11 protein entries:     UB2D3_HUMAN (see all proteins) (see all similar genes):
    UBE2D2    UBE2D1    UBE2D4    UBE2E3    HR6A    UBE2E1
    UBE2DNL    UBE2A    UBE2E2    UBE2B    UBE2M    UBE2H
    UBE2K    UBE2L3    UBE2N    UBE2G2    UBE2NL    UBE2G1

    UBE2D3 for paralogs           About GeneDecksing


    5/7 Pseudogenes.org Pseudogenes for UBE2D3 (see all 7)
    PGOHUM00000248651 PGOHUM00000247780 PGOHUM00000247141 PGOHUM00000251136 PGOHUM00000237994


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1452 SNPs in UBE2D3 are shown (see all 1452)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs753837561,2
    --99467213(+) ACAAGC/TGAGTC 9 -- int11Minor allele frequency- T:0.50CSA 2
    rs1836569671,2
    --103716645(+) TGCAGC/TATGAC 9 -- ds5001 int10--------
    rs1458215421,2
    --103716780(+) CAGAAC/GGCATG 9 -- ds5001 int10--------
    rs1477734431,2
    --103716853(+) AAATGC/TTTATA 9 -- ds5001 int10--------
    rs1892026661,2
    --103716880(+) ATTTAC/TTTCTA 9 -- ds5001 int10--------
    rs1154463251,2
    C,F--103716967(+) AGTCAC/TAGATG 9 -- ds5001 int11Minor allele frequency- T:0.03WA 118
    rs99422581,2
    C,F--103717014(+) CAAAAT/CAAACA 9 -- ds5001 int11Minor allele frequency- C:0.05WA 118
    rs1410863891,2
    --103717058(+) AAAGGC/TGAAGA 9 -- ds5001 int10--------
    rs1819598111,2
    --103717180(+) AAATGA/GTATCT 9 -- ut310--------
    rs753535211,2
    C--103717376(+) ACAAGA/GTGAAG 9 -- ut310--------

    HapMap Linkage Disequilibrium report for UBE2D3 (103715540 - 103790053 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for UBE2D3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv965e199CNV Deletion23128226
    esv2672686CNV Deletion23128226
    esv2675680CNV Deletion23128226
    esv2728080CNV Deletion23290073
    esv23610CNV Loss19812545
    nsv10541CNV Loss18304495
    nsv879683CNV Loss21882294
    nsv526256CNV Loss19592680
    dgv1655e1CNV Complex17122850
    dgv1656e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602963    OMIM disorders: --

    18 diseases for UBE2D3:    About MalaCards
    limb-girdle muscular dystrophy type 2h    oxyphilic adenoma    limb-girdle muscular dystrophy    orofacial cleft
    gigantism    muscular dystrophy    conjunctivitis    alcohol dependence
    scleroderma    diffuse large b-cell lymphoma    alcoholism    hypoxia
    b-cell lymphomas    adenoma    parkinson's disease    gastric cancer
    leukemia    breast cancer


    UBE2D3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): UBE2D3
    Human Genome Epidemiology (HuGE) Navigator: UBE2D3 (2 documents)

    Export disorders for UBE2D3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2D3 gene, integrated from 9 sources (see all 196):
    (articles sorted by number of sources associating them with UBE2D3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of closely related human ubiquitin conjugating enzymes. (PubMed id 8530467)1, 2, 3 Jensen J.P.... Weissman A.M. (1995)
    2. Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. (PubMed id 15247280)1, 2, 9 Rajendra R.... Rubin E.H. (2004)
    3. Priming and extending: a UbcH5/Cdc34 E2 handoff mecha nism for polyubiquitination on a SCF substrate. (PubMed id 20347421)1, 2 Wu K....Pan Z.Q. (2010)
    4. A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (2010)
    5. PCNA is ubiquitinated by RNF8. (PubMed id 18948756)1, 2 Zhang S.... Lee M.Y.W.T. (2008)
    6. Physical and functional interactions between ZIP kinase and UbcH5. (PubMed id 18515077)1, 2 Ohbayashi N....Matsuda T. (2008)
    7. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. (PubMed id 18851830)1, 2 Saha A. and Deshaies R.J. (2008)
    8. A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. (PubMed id 16628214)1, 2 Polanowska J....Boulton S.J. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7323 HGNC: 12476 AceView: UBE2D3 Ensembl:ENSG00000109332 euGenes: HUgn7323
    ECgene: UBE2D3 Kegg: 7323 H-InvDB: UBE2D3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2D3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2D3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2D3 gene:
    Search GeneIP for patents involving UBE2D3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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