UBE2D2 Gene
protein-coding GIFtS: 64
GCID: GC05P138920
|
|
ubiquitin-conjugating enzyme E2D 2(Previous names: ubiquitin-conjugating enzyme E2D 2 (homologous to yeast...)
| |
Aliases
for UBE2D2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ubiquitin-Conjugating Enzyme E2D 21 2 | | UBCH5B2 3 | | UBC41 2 3 | | P53-Regulated Ubiquitin-Conjugating Enzyme 12 3 | | Ubiquitin-Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5)1 2 | | EC 6.3.2.193 8 | | Ubiquitin-Conjugating Enzyme E2D 2 (UBC4/5 Homolog, Yeast)1 2 | | UbcH5B1 | | Ubiquitin Carrier Protein D22 3 | | E2(17)KB22 | | Ubiquitin-Conjugating Enzyme E2(17)KB 22 3 | | UBC4/52 | | Ubiquitin-Conjugating Enzyme E2-17 KDa 22 3 | | Ubiquitin-Conjugating Enzyme E2 D22 | | Ubiquitin-Protein Ligase D22 3 | | UBC5B3 | | PUBC12 3 | | UBCH43 |
Export aliases for UBE2D2 gene to outside databasesPrevious GC identifers: GC05P138764 GC05P139524 GC05P138923 GC05P138969 GC05P134083 |
Summaries
for UBE2D2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for UBE2D2:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, orE1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of theE2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor proteinp53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been foundfor this gene and they encode distinct isoforms. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins.Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitinationof STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediatedGCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in themitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3
Gene Wiki entry for UBE2D2
|
Genomic Views
for UBE2D2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the UBE2D2 gene promoter:
p53 GATA-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for UBE2D2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2D2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.2 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.3UBE2D2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P138920: view genomic region
(about GC identifiers)
Start:
|
138,906,016 bp from pter |
End:
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139,008,019 bp from pter |
Size:
|
102,004 bases |
Orientation:
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plus strand |
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Proteins
for UBE2D2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837 (See
protein sequence)Recommended Name: Ubiquitin-conjugating enzyme E2 D2 Size: 147 amino acids; 16735 Da
Subunit: Interacts with PDZRN3 (By similarity). Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligasecomplex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases PJA1 and PJA2
6/17 PDB 3D structures from  and Proteopedia  for UBE2D2 (see all 17):1UR6 (3D)
1W4U (3D)
2C4O (3D)
2CLW (3D)
2ESK (3D)
2ESO (3D)
Secondary accessions: D3DQC9 P51669 Q3MN78 Q96RP6Alternative splicing: 2 isoforms: P62837-1 P62837-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for UBE2D2: NX_P62837
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P62837
4/11 DME Specific Peptides for UBE2D2 (P62837) (see all 11)
UBE2D2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_003330.1 NP_862821.1
ENSEMBL proteins: ENSP00000429613 ENSP00000381717 ENSP00000426523 ENSP00000381718 ENSP00000424941 ENSP00000253815 Reactome Protein details: P62837
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
UBE2D2 for ontologies About GeneDecksing
UBE2D2 Antibody Products:
Assay Products for UBE2D2: |
Protein
Domains /
Families
for UBE2D2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
UBE2D2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P62837ProtoNet protein and cluster: P62837 1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes
UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837Similarity: Belongs to the ubiquitin-conjugating enzyme family |
Function
for UBE2D2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins.Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitinationof STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediatedGCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in themitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysineEnzyme Number (IUBMB): EC 6.3.2.191 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): UBE2D2 (NM_003339) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2D2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D2 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
UBE2D2 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ube2d2atm1Ssw for UBE2D2
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ube2d2a):
UBE2D2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for UBE2D2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TRAF6 Mediated Induction of proinflammatory cytokines | | | 2 | Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha | | | 3 | Antigen processing: Ubiquitination & Proteasome degradation | | | 4 | Immune System | | | 5 | RNF125 mediated ubiquitination of RIG-I, MDA5 and IPS-1 | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for UBE2D2
3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2D2
4  BioSystems Pathways for UBE2D2
5/22 
Reactome Pathways for UBE2D2 (see all 22)
3 
Kegg Pathways (Kegg details for UBE2D2):
UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837Pathway: Protein modification; protein ubiquitination
UBE2D2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2D2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/214 Interacting proteins for UBE2D2 (P628371, 2, 3 ENSP000003817174) via UniProtKB, MINT, STRING, and/or I2D (see all 214)
| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RNF5 | Q999421, 2, 3, ENSP000003642354 | EBI-347677,EBI-348482 MINT-62677 MINT-62753 MINT-62579 I2D:
score=5 STRING: ENSP00000364235 | | OTUB1 | Q96FW11, 2, 3 | EBI-347677,EBI-1058491 MINT-8388718 MINT-8388703 MINT-8388563 I2D:
score=5 | | ZNRF1 | Q8ND251, 3, ENSP000003350914 | EBI-347677,EBI-2129250 I2D:
score=2 STRING: ENSP00000335091 | | TRAF6 | Q9Y4K31, 3 | EBI-347677,EBI-359276 I2D:
score=2 | | RNF11 | Q9Y3C51, 2, 3, ENSP000002427194 | EBI-347677,EBI-2129167 MINT-60866 I2D:
score=6 STRING: ENSP00000242719 |
About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
UBE2D2 for ontologies About GeneDecksing
|
Drugs & Compounds
for UBE2D2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for UBE2D2
4 HMDB Compounds for UBE2D2 About this table
1 DrugBank Compound for UBE2D2 About this table
Search CenterWatch for drugs/clinical trials and news about UBE2D2 / UB2D2
|
Transcripts
for UBE2D2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for UBE2D2 gene (2 alternative transcripts): NM_003339.2 NM_181838.1 Unigene Cluster for UBE2D2: Ubiquitin-conjugating enzyme E2D 2 Hs.108332 [show with all ESTs]Unigene Representative Sequence: NM_1818388 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000511725 ENST00000398733(uc003ler.3) ENST00000505007 ENST00000510470
ENST00000398734 ENST00000505548 ENST00000511691 ENST00000253815(uc003leq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): UBE2D2 (NM_003339) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2D2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D2 |
Additional cDNA sequence: AF317220.1 AK001311.1 AK001428.1 AK310273.1 AY651263.1 BC019052.2 BC033349.1 BC048426.1 U39317.1 15 DOTS entries: DT.100800484 DT.319277 DT.100828335 DT.100828340 DT.100731149 DT.100037876 DT.100828338 DT.120836914 DT.40123145 DT.100668950 DT.100828341 DT.120836919 DT.91867306 DT.95221810 DT.97859662 24/423 AceView cDNA sequences (see all 423): BE886869 BI222442 AI372006 AI559459 BU069134 BC019052 CR592107 BG403063 CB177912 BI093502 CA427384 BM980556 BE645754 CR594111 BM989667 BE895440 AI185519 CR623635 CB853137 CR622545 C05517 AA431868 AI280878 AI468703
GeneLoc Exon Structure
|
Expression
for UBE2D2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| UBE2D2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCTGTGTC
About this image
See UBE2D2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2D2
SOURCE GeneReport for Unigene cluster: Hs.108332
SABiosciences Expression via Pathway-Focused PCR Array including UBE2D2: | Ubiquitination (Ubiquitylation) Pathway in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2D2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2D2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D2 |
Orthologs
for UBE2D2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2D2 gene from 9/34 species (see all 34) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ube2d2a1 , 5 |
ubiquitin-conjugating enzyme E2D 25
ubiquitin-conjugating enzyme E2D 2A1 |
97.28(n)1
100(a)1 |
|
18 (19.24 cM)5
565501 NM_019912.21 NP_064296.11
357715595 |
chicken
(Gallus gallus) |
Aves |
F1NKS9_CHICK6 |
Uncharacterized protein |
99(a) |
1 ↔ 1 |
13(898227-918259) |
lizard
(Anolis carolinensis) |
Reptilia |
UBE2D26 |
-- |
100(a) |
1 ↔ 1 |
4(79233655-79248588) |
zebrafish
(Danio rerio) |
Actinopterygii |
BC048896.12 |
-- |
79.63(n) |
|
393934 BC048896.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
eff1 , 3 |
ubiquitin cycle ubiquitin conjugating enzyme3
effete1 |
94(a)
(best of 3)3
77.1(n)1
94.56(a)1 |
|
3 88D23
417851 NM_169601.11 NP_731941.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
let-701 , 3 |
ubiquitin-conjugating enzyme E2-17 KD3
Protein LET-701 |
93(a)3
76.42(n)1
93.88(a)1 |
|
IV(11081633-11082511)3
1780061 NM_069664.31 NP_502065.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
UBC41 |
Ubc4p |
68.98(n)
80.56(a) |
|
852376 NP_009638.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
UBC111 |
ubiquitin-conjugating enzyme E2 11 |
70.29(n)
79.59(a) |
|
820016 NM_111703.3 NP_566331.1 |
rice
(Oryza sativa) |
Liliopsida |
AB074411.12 |
-- |
74.14(n) |
|
AB074411.1 |
ENSEMBL Gene Tree for UBE2D2 (if available)
TreeFam Gene Tree for UBE2D2 (if available) |
Paralogs
for UBE2D2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for UBE2D2 gene
- UBE2D32 ENSG000002586772 UBE2L62 UBE2D12 UBE2W2 UBE2E32 UBE2D42 UBE2E12
- UBE2E22 UBE2L32
18/30 SIMAP similar genes for UBE2D2 using alignment to 2 protein entries: UB2D2_HUMAN (see all proteins)
(see all similar genes):UBE2D3 UBE2D4 UBE2D1 UBE2E3 UBE2E1 HR6A
UBE2DNL UBE2A UBE2E2 UBE2L3 UBE2B UBE2N
UBE2H UBE2K UBE2G2 UBE2M UBE2T UBE2NL
UBE2D2 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for UBE2D2
PGOHUM00000243511 PGOHUM00000241879
|
Genomic Variants
for UBE2D2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for UBE2D2 (138906016 - 139008019 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for UBE2D2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2D2 |
|
Disorders
/ Diseases
for UBE2D2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
UBE2D2 for disorders About GeneDecksing
OMIM gene information: 602962
OMIM disorders: --
6  diseases for UBE2D2: About MalaCardsdna topoisomerase ii shigellosis myelodysplastic syndrome breast cancer
malaria hypoxia
Human Genome Epidemiology (HuGE) Navigator: UBE2D2 (4 documents)
Export disorders for UBE2D2 gene to outside databases
|
Publications
for UBE2D2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for UBE2D2 gene, integrated from 9 sources (see all 218):
(articles sorted by number of sources associating them with UBE2D2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a family of closely related human ubiquitin conjugating enzymes. (PubMed id 8530467)1, 2, 3 Jensen J.P.... Weissman A.M. (1995)
- Crystal structure of UbcH5b~ubiquitin intermediate: i nsight into the formation of the self-assembled E2~Ub conjugates. (PubMed id 20152160)1, 2 Sakata E....Kato K. (2010)
- Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PubMed id 18703417)1, 2 Chiang M.H....Chen H. (2008)
- Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. (PubMed id 18359941)1, 2 Grou C.P....Azevedo J.E. (2008)
- Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)1, 2 Guinn B.-A.... Mufti G.J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. (PubMed id 15001359)1, 2 Winkler G.S....Timmers H.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. (PubMed id 15280377)1, 2 Saville M.K....Lane D.P. (2004)
- PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. (PubMed id 12036302)1, 2 Yu P.... Cai T. (2002)
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External Searches for UBE2D2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing UBE2D2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing UBE2D2 gene
(According to HUGE)
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Specialized Databases showing UBE2D2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for UBE2D2 gene:
Search GeneIP for patents involving UBE2D2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for UBE2D2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for UBE2D2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2D2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2D2 | | | OriGene Protein Over-expression Lysate for UBE2D2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for UBE2D2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for UBE2D2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBE2D2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2D2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2D2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2D2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2D2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2D2 |
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| | | | Search Tocris compounds for UBE2D2 |
| |  |  |  |  | | | | | | Recombinant Protein for UBE2D2 |
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 | | | UBE2D2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D2 |
|  |  |  | | | | Search ThermoFisher Antibodies for UBE2D2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D2 |
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