Aliases for UBE2D2 Gene
- Ubiquitin-Conjugating Enzyme E2D 2 2 3
- UBCH5B 3 4 6
- UBC4 3 4 6
- Ubiquitin-Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5) 2 3
- P53-Regulated Ubiquitin-Conjugating Enzyme 1 3 4
- Ubiquitin-Conjugating Enzyme E2-17 KDa 2 3 4
- Ubiquitin Carrier Protein D2 3 4
- Ubiquitin-Protein Ligase D2 3 4
- EC 188.8.131.52 4 64
External Ids for UBE2D2 Gene
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
GeneCards Summary for UBE2D2 Gene
UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cellular Senescence. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2L6.
UniProtKB/Swiss-Prot for UBE2D2 Gene
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.