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Aliases for UBE2D2 Gene

Aliases for UBE2D2 Gene

  • Ubiquitin-Conjugating Enzyme E2D 2 2 3
  • UBCH5B 3 4 6
  • UBC4 3 4 6
  • Ubiquitin-Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5) 2 3
  • P53-Regulated Ubiquitin-Conjugating Enzyme 1 3 4
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 2 3 4
  • Ubiquitin Carrier Protein D2 3 4
  • Ubiquitin-Protein Ligase D2 3 4
  • EC 6.3.2.19 4 63
  • PUBC1 3 4
  • UBCH4 3 4
  • Ubiquitin-Conjugating Enzyme E2D 2 (UBC4/5 Homolog, Yeast) 2
  • Ubiquitin-Conjugating Enzyme E2(17)KB 2 4
  • Ubiquitin-Conjugating Enzyme E2 D2 3
  • E2(17)KB2 3
  • UBC4/5 3
  • UBC5B 4

External Ids for UBE2D2 Gene

Summaries for UBE2D2 Gene

Entrez Gene Summary for UBE2D2 Gene

  • Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for UBE2D2 Gene

UBE2D2 (Ubiquitin-Conjugating Enzyme E2D 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Cellular Senescence. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2D2 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Gene Wiki entry for UBE2D2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2D2 Gene

Genomics for UBE2D2 Gene

Genomic Location for UBE2D2 Gene

Start:
139,526,431 bp from pter
End:
139,628,434 bp from pter
Size:
102,004 bases
Orientation:
Plus strand

Genomic View for UBE2D2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2D2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2D2 Gene

Regulatory Elements for UBE2D2 Gene

Transcription factor binding sites by QIAGEN in the UBE2D2 gene promoter:

Proteins for UBE2D2 Gene

  • Protein details for UBE2D2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62837-UB2D2_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D2
    Protein Accession:
    P62837
    Secondary Accessions:
    • D3DQC9
    • P51669
    • Q3MN78
    • Q96RP6

    Protein attributes for UBE2D2 Gene

    Size:
    147 amino acids
    Molecular mass:
    16735 Da
    Quaternary structure:
    • Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3.

    Three dimensional structures from OCA and Proteopedia for UBE2D2 Gene

    Alternative splice isoforms for UBE2D2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2D2 Gene

Proteomics data for UBE2D2 Gene at MOPED

Post-translational modifications for UBE2D2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys8 and Lys144

Other Protein References for UBE2D2 Gene

Domains for UBE2D2 Gene

Gene Families for UBE2D2 Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for UBE2D2 Gene

Suggested Antigen Peptide Sequences for UBE2D2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62837

UniProtKB/Swiss-Prot:

UB2D2_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.:
    • P62837
genes like me logo Genes that share domains with UBE2D2: view

Function for UBE2D2 Gene

Molecular function for UBE2D2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3.

Enzyme Numbers (IUBMB) for UBE2D2 Gene

Gene Ontology (GO) - Molecular Function for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18359941
GO:0005515 protein binding IPI 14667819
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2D2: view

Phenotypes for UBE2D2 Gene

MGI mutant phenotypes for UBE2D2:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with UBE2D2: view

Animal Models for UBE2D2 Gene

MGI Knock Outs for UBE2D2:

No data available for Transcription Factor Targeting and HOMER Transcription for UBE2D2 Gene

Localization for UBE2D2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2D2 Gene COMPARTMENTS Subcellular localization image for UBE2D2 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 4
nucleus 4
extracellular 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 15247280
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 22797923
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with UBE2D2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBE2D2 Gene

Pathways for UBE2D2 Gene

genes like me logo Genes that share pathways with UBE2D2: view

UniProtKB/Swiss-Prot P62837-UB2D2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2D2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 15247280
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006464 cellular protein modification process TAS 8090726
genes like me logo Genes that share ontologies with UBE2D2: view

Compounds for UBE2D2 Gene

(4) HMDB Compounds for UBE2D2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for UBE2D2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
(R,R)-2,3-Butanediol
24347-58-8 target
genes like me logo Genes that share compounds with UBE2D2: view

Transcripts for UBE2D2 Gene

Unigene Clusters for UBE2D2 Gene

Ubiquitin-conjugating enzyme E2D 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D2 Gene

No ASD Table

Relevant External Links for UBE2D2 Gene

GeneLoc Exon Structure for
UBE2D2
ECgene alternative splicing isoforms for
UBE2D2

Expression for UBE2D2 Gene

mRNA expression in normal human tissues for UBE2D2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UBE2D2 Gene

SOURCE GeneReport for Unigene cluster for UBE2D2 Gene Hs.108332

genes like me logo Genes that share expressions with UBE2D2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBE2D2 Gene

Orthologs for UBE2D2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBE2D2 35
  • 99.77 (n)
  • 100 (a)
UBE2D2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBE2D2 35
  • 98.64 (n)
  • 100 (a)
UBE2D2 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2D2 35
  • 97.96 (n)
  • 100 (a)
UBE2D2 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2d2a 35
  • 97.28 (n)
  • 100 (a)
Ube2d2a 16
Ube2d2a 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBE2D2 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2D2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2d2 35
  • 97.28 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves UBE2D2 35
  • 95.98 (n)
  • 98.58 (a)
lizard
(Anolis carolinensis)
Reptilia UBE2D2 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2d3 35
  • 87.3 (n)
  • 100 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
ube2d2l 36
  • 97 (a)
OneToMany
zgc:77149 35
  • 83.45 (n)
  • 98.64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000145 35
  • 75.74 (n)
  • 94.56 (a)
fruit fly
(Drosophila melanogaster)
Insecta eff 35
  • 77.1 (n)
  • 94.56 (a)
eff 36
  • 95 (a)
OneToMany
CG10862 37
  • 50 (a)
eff 37
  • 94 (a)
CG2574 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea let-70 35
  • 76.42 (n)
  • 93.88 (a)
let-70 36
  • 94 (a)
OneToMany
let-70 37
  • 93 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER173C 35
  • 66.89 (n)
  • 80.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UBC4 35
  • 68.98 (n)
  • 80.56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12563g 35
  • 70.32 (n)
  • 80.82 (a)
soybean
(Glycine max)
eudicotyledons Gma.6374 35
rice
(Oryza sativa)
Liliopsida Os09g0293400 35
  • 65.76 (n)
  • 77.55 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02289 35
  • 66.44 (n)
  • 82.99 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ubc4 35
  • 72.79 (n)
  • 84.35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10809 36
  • 85 (a)
OneToMany
Species with no ortholog for UBE2D2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2D2 Gene

ENSEMBL:
Gene Tree for UBE2D2 (if available)
TreeFam:
Gene Tree for UBE2D2 (if available)

Paralogs for UBE2D2 Gene

Paralogs for UBE2D2 Gene

Pseudogenes.org Pseudogenes for UBE2D2 Gene

genes like me logo Genes that share paralogs with UBE2D2: view

Variants for UBE2D2 Gene

Sequence variations from dbSNP and Humsavar for UBE2D2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs10241 -- 139,627,424(-) TAGGG(A/T)GATGT utr-variant-3-prime
rs149308 -- 139,568,067(-) accgc(A/G)cccag intron-variant
rs165179 -- 139,606,109(+) GTCTC(C/T)GGGGA intron-variant
rs165180 -- 139,608,363(+) gggag(G/T)cagag intron-variant
rs166363 -- 139,564,356(-) gccaa(C/G)atggt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2D2 Gene

Variant ID Type Subtype PubMed ID
nsv519808 CNV Loss 19592680
nsv830504 CNV Gain 17160897
nsv882941 CNV Loss 21882294
nsv882942 CNV Loss 21882294
nsv5028 CNV Insertion 18451855
nsv882943 CNV Loss 21882294
nsv830505 CNV Loss 17160897
nsv462460 CNV Loss 19166990

Relevant External Links for UBE2D2 Gene

HapMap Linkage Disequilibrium report
UBE2D2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2D2 Gene

Disorders for UBE2D2 Gene

Relevant External Links for UBE2D2

Genetic Association Database (GAD)
UBE2D2
Human Genome Epidemiology (HuGE) Navigator
UBE2D2
genes like me logo Genes that share disorders with UBE2D2: view

No data available for UniProtKB/Swiss-Prot for UBE2D2 Gene

Publications for UBE2D2 Gene

  1. Identification of a family of closely related human ubiquitin conjugating enzymes. (PMID: 8530467) Jensen J.P. … Weissman A.M. (J. Biol. Chem. 1995) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IkappaBalpha. (PMID: 10329681) Gonen H. … Ciechanover A. (J. Biol. Chem. 1999) 3 4
  4. SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4. (PMID: 10918611) Strack P. … Rolfe M. (Oncogene 2000) 3 4
  5. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. (PMID: 15001359) Winkler G.S. … Timmers H.T. (J. Mol. Biol. 2004) 3 4

Products for UBE2D2 Gene

Sources for UBE2D2 Gene

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