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UBE2D2 Gene

protein-coding   GIFtS: 67
GCID: GC05P138920

Ubiquitin-Conjugating Enzyme E2D 2

(Previous names: ubiquitin-conjugating enzyme E2D 2 (homologous to yeast...)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2D 21 2     EC 6.3.2.193 8
UBC42 3 5     Ubiquitin-Conjugating Enzyme E2D 2 (UBC4/5 Homolog, Yeast)1
UBCH5B2 3 5     E2(17)KB22
Ubiquitin-Conjugating Enzyme E2D 2 (Homologous To Yeast UBC4/5)1 2     UBC4/52
Ubiquitin Carrier Protein D22 3     Ubiquitin-Conjugating Enzyme E2 D22
Ubiquitin-Conjugating Enzyme E2-17 KDa 22 3     UBC5B3
Ubiquitin-Protein Ligase D22 3     UBCH43
PUBC12 3     Ubiquitin-Conjugating Enzyme E2(17)KB 23
P53-Regulated Ubiquitin-Conjugating Enzyme 12 3     

External Ids:    HGNC: 124751   Entrez Gene: 73222   Ensembl: ENSG000001315087   OMIM: 6029625   UniProtKB: P628373   

Export aliases for UBE2D2 gene to outside databases

Previous GC identifers: GC05P138764 GC05P139524 GC05P138923 GC05P138969 GC05P134083


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2D2 Gene:
Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin
(Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and
covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S
proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1
(ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a
member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and
peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this
gene. (provided by RefSeq, May 2013)

GeneCards Summary for UBE2D2 Gene:
UBE2D2 (ubiquitin-conjugating enzyme E2D 2) is a protein-coding gene. Diseases associated with UBE2D2 include lafora disease, and shigellosis. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal
proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and
autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of
NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the
activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral
activation of IRF3

Gene Wiki entry for UBE2D2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2D2 gene promoter:
         p53   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2D2 promoter sequence
   Search Chromatin IP Primers for UBE2D2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2D2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.2

UBE2D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2D2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P138920:  view genomic region     (about GC identifiers)

Start:
138,906,016 bp from pter      End:
139,008,019 bp from pter
Size:
102,004 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 D2  
Size: 147 amino acids; 16735 Da
Subunit: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex. Interacts with CNOT4 (via RING
domain). Interacts with E3 ubiquitin-protein ligases CBLC, PJA1 and PJA2. Interacts with PDZRN3
Selected PDB 3D structures from and Proteopedia for UBE2D2 (see all 20):
1UR6 (3D)        1W4U (3D)        2C4O (3D)        2CLW (3D)        2ESK (3D)        2ESO (3D)    
Secondary accessions: D3DQC9 P51669 Q3MN78 Q96RP6
Alternative splicing: 2 isoforms:  P62837-1   P62837-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2D2: NX_P62837

Explore proteomics data for UBE2D2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys8, Lys144
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for UBE2D2 (P62837) (see all 11)
     DREKYNR  CSAGPVG  YPFKPPK  PLVPEIA 


    See UBE2D2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003330.1  NP_862821.1  

    ENSEMBL proteins: 
     ENSP00000429613   ENSP00000381717   ENSP00000426523   ENSP00000381718   ENSP00000424941  
     ENSP00000253815  
    Reactome Protein details: P62837

    UBE2D2 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant UBE2D2 Protein
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    Enzo Life Sciences proteins for UBE2D2
    OriGene Purified Proteins for UBE2D2
    OriGene Protein Over-expression Lysate for UBE2D2
    OriGene MassSpec for UBE2D2
    OriGene Custom Protein Services for UBE2D2
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    Novus Biologicals UBE2D2 Proteins
    Novus Biologicals UBE2D2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBE2D2
    Cloud-Clone Corp. Proteins for UBE2D2

    UBE2D2 Antibody Products:

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    Novus Biologicals UBE2D2 Antibodies
    Abcam antibodies for UBE2D2
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    UBE2D2 Assay Products:

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    Cloud-Clone Corp. CLIAs for UBE2D2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry P62837

    ProtoNet protein and cluster: P62837

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2D2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2D2_HUMAN, P62837
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal
    proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and
    autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of
    NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the
    activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral
    activation of IRF3
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15247280
    GO:0005515protein binding IPI14667819
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2D2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ube2d2a):
     reproductive system 

    UBE2D2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ube2d2atm1Ssw for UBE2D2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2D2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2D2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2D2

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2D2:
    hsa-mir-30c-5p (MIRT047862), hsa-mir-215-5p (MIRT024527), hsa-mir-10a-5p (MIRT047680), hsa-let-7b-5p (MIRT032280), hsa-mir-155-5p (MIRT020586), hsa-mir-192-5p (MIRT026243)

    Block miRNA regulation of human, mouse, rat UBE2D2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2D2 (see all 60):
    hsa-miR-548j hsa-miR-376b hsa-miR-16-1* hsa-miR-301a hsa-miR-30d hsa-miR-342-3p hsa-miR-105 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidUBE2D2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UBE2D2
    Predesigned siRNA for gene silencing in human, mouse, rat UBE2D2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for UBE2D2

    Clone
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    OriGene clones in human, mouse for UBE2D2 (see all 11)
    OriGene ORF clones in mouse, rat for UBE2D2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBE2D2 (NM_003339)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2D2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D2

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endosome5
    plasma membrane5
    cytosol4
    nucleus4
    extracellular1
    peroxisome1
    vacuole1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex IDA15247280
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    UBE2D2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2D2 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    2Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
    Regulation of Hypoxia-inducible Factor (HIF) by Oxygen1.00
    Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha0.00
    Cellular response to hypoxia1.00
    3Toll Like Receptor 7/8 (TLR7/8) Cascade
    MyD88-independent cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69
    4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    Negative regulators of RIG-I/MDA5 signaling0.42
    5Cellular Senescence
    Cellular responses to stress0.81

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2D2
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions
    WNT Signaling

    4 BioSystems Pathways for UBE2D2
        TGF-beta Receptor Signaling Pathway
    Proteasome Degradation
    TNF-alpha/NF-kB Signaling Pathway
    Internalization of ErbB1

    4 Reactome Pathways for UBE2D2
        IKK complex recruitment mediated by RIP1
    Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
    Antigen processing: Ubiquitination & Proteasome degradation
    Negative regulators of RIG-I/MDA5 signaling


    3 Kegg Pathways  (Kegg details for UBE2D2):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum
    Shigellosis

    UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837
    Pathway: Protein modification; protein ubiquitination


    UBE2D2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2D2: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2D2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2D2 (P628371, 2, 3 ENSP000003817174) via UniProtKB, MINT, STRING, and/or I2D (see all 301)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RNF5Q999421, 2, 3, ENSP000003642354EBI-347677,EBI-348482 MINT-62677 MINT-62753 MINT-62579 I2D: score=5 STRING: ENSP00000364235
    ENSG00000183574Q999421, 2, 3EBI-347677,EBI-348482 MINT-62677 MINT-62753 MINT-62579 I2D: score=5 
    ENSG00000223767Q999421, 2, 3EBI-347677,EBI-348482 MINT-62677 MINT-62753 MINT-62579 I2D: score=5 
    ENSG00000225452Q999421, 2, 3EBI-347677,EBI-348482 MINT-62677 MINT-62753 MINT-62579 I2D: score=5 
    ENSG00000227277Q999421, 2, 3EBI-347677,EBI-348482 MINT-62677 MINT-62753 MINT-62579 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA15247280
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--
    GO:0006464cellular protein modification process TAS8090726
    GO:0006511ubiquitin-dependent protein catabolic process TAS7724550

    UBE2D2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2D2 (UB2D2)

    4 HMDB Compounds for UBE2D2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 DrugBank Compound for UBE2D2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (R,R)-2,3-Butanediol-- 24347-58-8target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for UBE2D2 gene (2 alternative transcripts): 
    NM_003339.2  NM_181838.1  

    Unigene Cluster for UBE2D2:

    Ubiquitin-conjugating enzyme E2D 2
    Hs.108332  [show with all ESTs]
    Unigene Representative Sequence: NM_181838
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000511725 ENST00000398733(uc003ler.3) ENST00000505007 ENST00000510470
    ENST00000398734 ENST00000505548 ENST00000511691 ENST00000253815(uc003leq.3)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat UBE2D2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBE2D2 (see all 60):
    hsa-miR-548j hsa-miR-376b hsa-miR-16-1* hsa-miR-301a hsa-miR-30d hsa-miR-342-3p hsa-miR-105 hsa-miR-30a
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    GenScript: all cDNA clones in your preferred vector (see all 2): UBE2D2 (NM_003339)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for UBE2D2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2D2
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2D2
      QuantiFast Probe-based Assays in human, mouse, rat UBE2D2

    Additional mRNA sequence: 

    AF317220.1 AK001311.1 AK001428.1 AK310273.1 AY651263.1 BC019052.2 BC033349.1 BC048426.1 
    U39317.1 

    15 DOTS entries:

    DT.100800484  DT.319277  DT.100828335  DT.100828340  DT.100731149  DT.100037876  DT.100828338  DT.120836914 
    DT.40123145  DT.100668950  DT.100828341  DT.120836919  DT.91867306  DT.95221810  DT.97859662 

    Selected AceView cDNA sequences (see all 423):

    BU069134 BM693773 BQ184674 AI268386 AA297216 AI185519 BE909144 CB529566 
    AV654243 BI467183 BM770383 AI693793 BG403063 BM784690 AW168331 AI919393 
    AW070669 BM791339 F05261 AA662534 R84887 BI324901 BM930740 BU173037 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    UBE2D2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCTGTGTC
    UBE2D2 Expression
    About this image


    UBE2D2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thyroid (Endocrine System)
     
     Colon (Gastrointestinal Tract)
     
     Testis (Reproductive System)
     
     Esophagus (Gastrointestinal Tract)
    UBE2D2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2D2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.108332
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2D2: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2D2 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2d2a1 , 5 ubiquitin-conjugating enzyme E2D 25
    ubiquitin-conjugating enzyme E2D 2A1
    97.28(n)1
    100(a)1
      18 (19.24 cM)5
    565501  NM_019912.21  NP_064296.11 
     357715595 
    chicken
    (Gallus gallus)
    Aves UBE2D21 ubiquitin-conjugating enzyme E2D 2 95.98(n)
    98.58(a)
      416137  XM_414470.4  XP_414470.4 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2D26
    ubiquitin-conjugating enzyme E2D 2
    100(a)
    1 ↔ 1
    4(79233652-79248588)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ube2d31 ubiquitin-conjugating enzyme E2D 3 87.3(n)
    100(a)
      548818  NM_001016064.2  NP_001016064.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC048896.12   -- 79.63(n)   393934  BC048896.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eff1 , 3 ubiquitin cycle ubiquitin conjugating
    enzyme3
    effete1
    94(a)
    (best of 3)3
    77.1(n)1
    94.56(a)1
      3 88D23
    417851  NM_001275649.11  NP_001262578.11 
    worm
    (Caenorhabditis elegans)
    Secernentea let-701 , 3 ubiquitin-conjugating enzyme E2-17 KD3
    let-701
    93(a)3
    76.42(n)1
    93.88(a)1
      IV(11081633-11082511)3
    1780061  NM_069664.41  NP_502065.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC41 UBC4 68.98(n)
    80.56(a)
      852376   NP_009638.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.63742 Transcribed sequence with weak similarity to protein more 75.06(n)  
    rice
    (Oryza sativa)
    Liliopsida AB074411.12   -- 74.14(n)    AB074411.1 


    ENSEMBL Gene Tree for UBE2D2 (if available)
    TreeFam Gene Tree for UBE2D2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2D2 gene
    UBE2D32  UBE2L62  UBE2D12  UBE2E32  UBE2D42  UBE2L32  UBE2E12  UBE2E22  
    Selected SIMAP similar genes for UBE2D2 using alignment to 2 protein entries:     UB2D2_HUMAN (see all proteins) (see all similar genes):
    UBE2D3    UBE2D4    UBE2D1    UBE2E3    UBE2E1    HR6A
    UBE2DNL    UBE2A    UBE2E2    UBE2B    UBE2M    UBE2N
    UBE2L3    UBE2H    UBE2K    UBE2G2    UBE2T    UBE2NL

    UBE2D2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for UBE2D2
    PGOHUM00000243511 PGOHUM00000241879


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2D2 (see all 1291)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930252221,2
    --138938787(+) CGGGCG/TGATCA 2 -- us2k10--------
    rs1847705811,2
    C--138938869(+) TACCCC/GGGCGT 2 -- us2k10--------
    rs1131762271,2
    C--138939011(+) GTCTC-/AAAAAA 2 -- us2k11Minor allele frequency- A:0.00CSA 2
    rs1885520171,2
    --138939247(+) TGTGTA/GGCTTT 2 -- us2k10--------
    rs1395852241,2
    --138939281(+) GGCTCC/TAGTTT 2 -- us2k10--------
    rs1917332951,2
    C--138939421(+) CAAAAC/TATTCT 2 -- us2k10--------
    rs1838988741,2
    --138939492(+) TGGTGC/TAGGGC 2 -- us2k10--------
    rs125166281,2
    C,H--138939567(+) ATATTC/TTAGGT 2 -- us2k15Minor allele frequency- T:0.00NS EA NA 526
    rs1497153701,2
    C--138939701(+) GCAACC/TTCTGC 2 -- us2k10--------
    rs1882793571,2
    --138939765(+) AGGAAA/CCTGCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2D2 (138906016 - 139008019 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for UBE2D2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5028CNV Insertion18451855
    nsv519808CNV Loss19592680
    nsv882943CNV Loss21882294
    nsv830505CNV Loss17160897
    nsv882942CNV Loss21882294
    nsv882941CNV Loss21882294
    nsv462460CNV Loss19166990
    nsv830504CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602962    OMIM disorders: --

    19 diseases for UBE2D2:    
    About MalaCards
    lafora disease    shigellosis    tauopathy    smallpox
    amyloidosis    wilms tumor    retinitis pigmentosa    myelodysplastic syndromes
    hypoxia    retinitis    b-cell lymphomas    parkinson's disease
    hiv-1    hypertension    alzheimer's disease    hepatocellular carcinoma
    neuronitis    malaria    breast cancer


    UBE2D2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): UBE2D2
    Human Genome Epidemiology (HuGE) Navigator: UBE2D2 (4 documents)

    Export disorders for UBE2D2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2D2 gene, integrated from 10 sources (see all 247):
    (articles sorted by number of sources associating them with UBE2D2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a family of closely related human ubiquitin conjugating enzymes. (PubMed id 8530467)1, 2, 3 Jensen J.P.... Weissman A.M. (J. Biol. Chem. 1995)
    2. Crystal structure of UbcH5b~ubiquitin intermediate: insight into the formation of the self-assembled E2~Ub conjugates. (PubMed id 20152160)1, 2 Sakata E.... Kato K. (Structure 2010)
    3. The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme. (PubMed id 20525694)1, 2 Ryan P.E....Lipkowitz S. (J. Biol. Chem. 2010)
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    5. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PubMed id 19240791)1, 4 Graubert T.A....Walter M.J. (PLoS ONE 2009)
    6. Ubiquitin-conjugating enzyme UBE2D2 is responsible for FBXW2 (F-box and WD repeat domain containing 2)-mediated human GCM1 (glial cell missing homolog 1) ubiquitination and degradation. (PubMed id 18703417)1, 2 Chiang M.H.... Chen H. (Biol. Reprod. 2008)
    7. Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. (PubMed id 18359941)1, 2 Grou C.P.... Azevedo J.E. (J. Biol. Chem. 2008)
    8. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)1, 2 Guinn B.-A.... Mufti G.J. (Biochem. Biophys. Res. Commun. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Solution structure of the ubiquitin-conjugating enzyme UbcH5B. (PubMed id 15522302)1, 2 Houben K....Boelens R. (J. Mol. Biol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7322 HGNC: 12475 AceView: UBE2D2 Ensembl:ENSG00000131508 euGenes: HUgn7322
    ECgene: UBE2D2 Kegg: 7322 H-InvDB: UBE2D2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2D2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2D2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2D2 gene:
    Search GeneIP for patents involving UBE2D2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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