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UBE2D2 Gene

protein-coding GIFtS: 63

GC05P138920

ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)
(Previous name: ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E2(17)KB2 ^²
EC 6.3.2.19 ^³
PUBC1 ^²
UBC4 ^¹, ², ³
UBC4/5 ^²
UBCH5B ^², ³
UbcH5B ^¹

Descriptions
E2(17)KB 2 ^³
Ubiquitin carrier protein D2 ^³
Ubiquitin-conjugating enzyme E2-17 kDa 2 ^², ³
Ubiquitin-protein ligase D2 ^³
ubiquitin carrier protein ^²
ubiquitin-conjugating enzyme E2 D2 ^²
ubiquitin-conjugating enzyme E2D 2 ^²
ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) ^²
ubiquitin-conjugating enzyme E2D 2 (homologous to yeast UBC4/5) ^¹, ²

External Ids
HGNC: 12475¹
Entrez Gene: 7322²
UniProtKB: P62837³
Ensembl: ENSG00000131508⁷

Search outside databases for aliases for UBE2D2 gene

Previous GC identifers: GC05P138764 GC05P139524 GC05P138923 GC05P138969

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for UBE2D2:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53,

which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants

have been found for this gene and they encode distinct isoforms. [provided by RefSeq]

UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination

of p53/TP53

Gene Wiki entry for UBE2D2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2D2 gene

Entrez Gene cytogenetic band: 5q31.2 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.3

UBE2D2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P138920: (about GC identifiers)

Start:	138,920,935 bp from pter
End:	138,988,203 bp from pter
Size:	67,269 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_029289.10

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 D2

Size: 147 amino acids; 16735 Da

Subunit: Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex and with E3

ubiquitin-protein ligase PJA2 (By similarity)

PDB structures from and Proteopedia :

1UR6 (3D)

1W4U (3D)

2C4O (3D)

2CLW (3D)

2ESK (3D)

2ESO (3D)

2ESP (3D)

2ESQ (3D)

Secondary accessions: P51669 Q3MN78

REFSEQ proteins (2 alternative transcripts):

NP_003330.1 NP_862821.1

ENSEMBL proteins:

ENSP00000381718 ENSP00000381717 ENSP00000253815

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBE2D2 Protein
	Sigma-Aldrich Proteins for UBE2D2
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2D2
	Recombinant Proteins from Abcam (UBE2D2)
	Human Recombinant Proteins from Abnova (UBE2D2)

OriGene Purified Recombinant Human Proteins (see all 2): UBE2D2

Antibodies for UBE2D2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of UBE2D2
	Sigma-Aldrich Antibodies for UBE2D2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE2D2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2D2)
	Novus Biologicals Antibodies for UBE2D2

Assays for UBE2D2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2D2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P62837

ProtoNet protein and cluster: P62837

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2D2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2D2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_181838

Applied Biosystems Silencer® siRNAs for UBE2D2

Sigma-Aldrich siRNA and siRNA Panels for UBE2D2

Sigma-Aldrich shRNA Panels and shRNA for UBE2D2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003339
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003339
untagged cDNA clones in CMV expression vector (see all 3): AK001428

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003339

UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination

of p53/TP53

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ube2d2):

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	TAS	8090726
GO:0005515	protein binding	IPI	12878161 14667819
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2D2 (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway
Hypoxia Signaling in the Cardiovascular System

GeneDecks UBE2D2 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UB2D2_HUMAN, P62837

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2D2

5/47 Interacting proteins for UBE2D2 (ENSP00000253815³ P62837^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 47 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000183574	Q99942¹^,²	EBI-347677, EBI-348482 MINT-62677 MINT-62753 MINT-62579
ENSG00000206254	Q99942¹^,²	EBI-347677, EBI-348482 MINT-62677 MINT-62753 MINT-62579
RNF5	Q99942¹^,²	EBI-347677, EBI-348482 MINT-62677 MINT-62753 MINT-62579 EBI-347677, EBI-348482 MINT-62677 MINT-62753 MINT-62579
RNF5	Q99942¹^,²	EBI-347677, EBI-348482 MINT-62677 MINT-62753 MINT-62579 EBI-347677, EBI-348482 MINT-62677 MINT-62753 MINT-62579
RNF11	Q9Y3C5²	MINT-60866

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	7724550
GO:0016567	protein ubiquitination	IDA	9990509
GO:0051246	regulation of protein metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2D2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2D2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2D2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_181838

Sigma-Aldrich siRNA and siRNA Panels for UBE2D2

Sigma-Aldrich shRNA Panels and shRNA for UBE2D2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003339 NM_181838

REFSEQ mRNAs for UBE2D2 gene (2 alternative transcripts):

NM_003339.2 NM_181838.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003339 NM_181838

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_003339
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_003339
                                 untagged cDNA clones in CMV expression vector (see all 3): AK001428

Additional cDNA sequence:

AF317220.1 AK001311.1 AK001428.1 AK310273.1 AY651263.1 BC019052.2 BC033349.1 BC048426.1

CR591688.1 CR592107.1 CR594111.1 CR596483.1 CR606151.1 CR607642.1 CR611730.1 CR618308.1

CR622545.1 CR623635.1 U39317.1

15 DOTS entries:

DT.100800484 DT.319277 DT.100828335 DT.100828340 DT.100731149 DT.100037876 DT.100828338 DT.120836914

DT.40123145 DT.100668950 DT.100828341 DT.120836919 DT.91867306 DT.95221810 DT.97859662

24/423 AceView cDNA sequences (see all 423 ):

BU542791 BM770383 CA427384 AW168331 BM791339 AI372006 BU609158 AI933490

CB853137 AA297216 AI955197 AI559459 BU733337 BE886869 BM930740 CB177912

BX443090 CR607642 BQ639894 BM685264 BF037887 BQ940385 AI587443 CB529566

highest scoring ESTs for UBE2D2:

AI432424 U39317 AA010414 AA011242 AA039754 AA058377 AA128361 AA128524 AA128739 AA128740

Unigene Cluster for UBE2D2:

Ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)

Hs.108332 [show with all ESTs]

Unigene Representative Sequence: NM_181838

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000398734 ENST00000398733 ENST00000253815

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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UBE2D2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2D2

¹ / ² / ³

9 probe-sets matching UBE2D2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50909_at²^{, 3}	U95-B	1	1.00	1.00	0.78	0.78	AI432424	1.00	1.00	1.00	1
832_at²^{, 3}	U95-A	1	1.00	1.00	0.59	1.09	U39317	1.00	1.00	1.00	1
38705_at²^{, 3}	U95-A	1	1.00	1.00	0.95	1.14	AI310002	0.80	1.00	0.91	1
201345_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003339	0.60	1.00	0.82	1
201344_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF196642	0.80	1.00	0.91	1
201343_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BE621259	0.80	1.00	0.91	1
201345_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201344_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201343_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks UBE2D2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AAGCTGTGTC

SOURCE GeneReport for Unigene cluster: Hs.108332
Expression variation in blood from EXPOLDB for UBE2D2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2D2 gene from 5/22 species (see all 22 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2D2¹	--	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, more	97.96(n) 100(a)	612742 XM_850849.1 XP_855942.1
chimpanzee (Pan troglodytes)	UBE2D2¹	--	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, more	99.77(n) 100(a)	462108 XM_517968.2 XP_517968.1
cow (Bos taurus)	UBE2D2¹	--	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, more	98.64(n) 100(a)	541003 NM_001046496.1 NP_001039961.1
rat (Rattus norvegicus)	Ube2d2¹	--	ubiquitin-conjugating enzyme E2D 2	97.28(n) 100(a)	641452 NM_001037292.1 NP_001032369.1
mouse (Mus musculus)	Ube2d2^{1, 5}	18⁵	ubiquitin-conjugating enzyme E2D 2^{1, 5}	97.28(n)¹ 100(a)¹	56550¹ NM_019912.1¹ NP_064296.1¹ AK005355⁵ AK075844⁵ (see all 23)

About this table Species with no ortholog for UBE2D2

ENSEMBL Gene Tree for UBE2D2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for UBE2D2 gene

UBE2D3P² UBE2D1² UBE2D4²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/269 NCBI SNPs in UBE2D2 are shown (see all 269 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs181494^1,2	C,H	138988548(-)	`gcctaG/Aaaggt`	2	--	ng3¹		4		EU EA WA	400
	rs12516628^1,2	C,H	138919751(+)	`ATATTC/TTAGGT`	2	--	ng5¹		4		EU EA WA	418
--	rs356426^1,2	A,C	138988686(-)	`gagccC/Taggag`	2	--	ng3¹		0	--	--	--	--
--	rs13359150^1,2	H	138987810(+)	`TTGGTA/GAGTTA`	2	--	ut3¹		4		EU EA WA	412
	rs769052^1,2	A,C,F,H,O	138924617(+)	`ACAGCT/CAGTGA`	2	--	int¹		8		MN EU EA WA NA	746
	rs165179^1,2	A,C,F,H,O	138965878(+)	`GTCTCT/CGGGGA`	2	--	int¹		12		EU EA WA	1258
	rs356428^1,2	C,F,H,O	138972887(+)	`TTCCTA/GTCCTT`	2	--	int¹		8		EU EA WA	834
	rs355148^1,2	C,F,H,O	138955008(-)	`CGGAAC/TATGTG`	2	--	int¹		7		EU EA WA NA	544
	rs356427^1,2	A,C,F,H	138984673(-)	`TTTGAC/GAATAA`	2	--	int¹		4		EU EA WA	416
	rs403583^1,2	A,C,F,H	138960558(-)	`ATTTCG/ACAAGT`	2	--	int¹		8		EU EA WA	838

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HapMap Linkage Disequilibrium images for UBE2D2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602962

1 PharmGKB disease relationship for UBE2D2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Human Genome Epidemiology Navigator: UBE2D2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/44 PubMed articles for UBE2D2 gene (see all 44 ):

Identification of a family of closely related human ubiquitin conjugating enzymes. (PubMed id 8530467)^{2, 3, 4} Jensen J.P....Weissman A.M. (1995)
Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia. (PubMed id 16112646)^{3, 4} Guinn B.-A.... Mufti G.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
SCF(beta-TRCP) and phosphorylation dependent ubiquitination of I kappa B alpha catalyzed by Ubc3 and Ubc4. (PubMed id 10918611)^{3, 4} Strack P.... Rolfe M. (2000)
Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP). (PubMed id 7724550)^{3, 4} Rolfe M.... Draetta G. (1995)
Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. (PubMed id 9990509)^{1, 3} Anan T....Nakao M. (1998)
E2-c-Cbl recognition is necessary but not sufficient for ubiquitination activity. (PubMed id 18996392)^{1, 3} Huang A....Boelens R. (2009)
Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. (PubMed id 9182527)^{1, 3} Hatakeyama S....Weissman A.M. (1997)
Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PubMed id 19240791)³ Graubert T.A....Walter M.J. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 7322	HGNC: 12475	AceView: UBE2D2	Ensembl:ENSG00000131508	euGenes: HUgn7322
ECgene: UBE2D2	H-InvDB: UBE2D2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for UBE2D2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE2D2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE2D2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2D2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
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	Predesigned and custom siRNAs for UBE2D2		Antibodies for UBE2D2
	Explore super-pooled esiRNAs		Proteins for UBE2D2
	Lentivirus-delivered shRNAs for UBE2D2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for UBE2D2

	Assays/Proteins for UBE2D2
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Antibodies for UBE2D2

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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UBE2D2 Gene at Home site.
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UBE2D2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for UBE2D2

Summaries
for UBE2D2

Genomic Location
for UBE2D2

Proteins
for UBE2D2

Protein Domains/
Families
for UBE2D2

Gene Function
for UBE2D2

Pathways & Interactions
for UBE2D2

Drugs & Compounds
for UBE2D2

Transcripts
for UBE2D2

Expression
for UBE2D2

Orthologs
for UBE2D2

Paralogs
for UBE2D2

SNPs/Variants
for UBE2D2

Disorders & Mutations
for UBE2D2

Medical News
for UBE2D2

Publications
for UBE2D2

Search for UBE2D2

Genome Databases showing UBE2D2

Other Databases showing UBE2D2

Specialized Databases showing UBE2D2

Licensable Technologies
for UBE2D2

Services
for UBE2D2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2D2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor UBE2D2

Summariesfor UBE2D2

Genomic Locationfor UBE2D2

Proteinsfor UBE2D2

Protein Domains/Familiesfor UBE2D2

Gene Functionfor UBE2D2

Pathways & Interactionsfor UBE2D2

Drugs & Compoundsfor UBE2D2

Transcriptsfor UBE2D2

Expression for UBE2D2

Orthologsfor UBE2D2

Paralogsfor UBE2D2

SNPs/Variantsfor UBE2D2

Disorders & Mutationsfor UBE2D2

Medical Newsfor UBE2D2

Publicationsfor UBE2D2

Search for UBE2D2

Genome Databases showing UBE2D2

Other Databases showing UBE2D2

Specialized Databases showing UBE2D2

Licensable Technologiesfor UBE2D2

Servicesfor UBE2D2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2D2

Summaries
for UBE2D2

Genomic Location
for UBE2D2

Proteins
for UBE2D2

Protein Domains/
Families
for UBE2D2

Gene Function
for UBE2D2

Pathways & Interactions
for UBE2D2

Drugs & Compounds
for UBE2D2

Transcripts
for UBE2D2

Expression
for UBE2D2

Orthologs
for UBE2D2

Paralogs
for UBE2D2

SNPs/Variants
for UBE2D2

Disorders & Mutations
for UBE2D2

Medical News
for UBE2D2

Publications
for UBE2D2

Licensable Technologies
for UBE2D2

Services
for UBE2D2