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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2D1 Gene

protein-coding   GIFtS: 70
GCID: GC10P060094

Ubiquitin-Conjugating Enzyme E2D 1

(Previous names: stimulator of Fe transport, ubiquitin-conjugating enzyme...)
(Previous symbol: SFT)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin-Conjugating Enzyme E2D 11 2     Ubiquitin-Protein Ligase D12 3
Stimulator Of Fe Transport1 2 3     UBC4/5 Homolog2 3
SFT1 2 3     EC 6.3.2.193 8
UBCH52 3 5     E2(17)KB12
UBCH5A2 3 5     UBC4/52
Ubiquitin-Conjugating Enzyme E2D 1 (UBC4/5 Homolog, Yeast)1 2     Ubiquitin-Conjugating Enzyme E2 D12
Ubiquitin Carrier Protein D12 3     UBC5A3
Ubiquitin-Conjugating Enzyme E2(17)KB 12 3     UbcH53
Ubiquitin-Conjugating Enzyme E2-17 KDa 12 3     

External Ids:    HGNC: 124741   Entrez Gene: 73212   Ensembl: ENSG000000724017   OMIM: 6029615   UniProtKB: P516683   

Export aliases for UBE2D1 gene to outside databases

Previous GC identifers: GC10P058890 GC10P059120 GC10P059987 GC10P059439 GC10P059764 GC10P054083


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBE2D1 Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to
a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the
ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by
interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2011)

GeneCards Summary for UBE2D1 Gene: 
UBE2D1 (ubiquitin-conjugating enzyme E2D 1) is a protein-coding gene. Diseases associated with UBE2D1 include nasal cavity neoplasm, and spindle cell lipoma, and among its related super-pathways are Regulation of APC/C activators between G1/S and early anaphase and Mitotic Spindle Checkpoint. GO annotations related to this gene include ubiquitin-protein ligase activity and ATP binding. An important paralog of this gene is UBE2D3.

UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal
proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and
auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks
inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3.
Mediates polyubiquitination of CYP3A4

Gene Wiki entry for UBE2D1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.2  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2D1 gene promoter:
         p53   Tal-1beta   Evi-1   E47   HNF-4alpha1   PPAR-alpha   c-Myb   TGIF   Pax-4a   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2D1 promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2D1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2D1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.1   Ensembl cytogenetic band:  10q21.1   HGNC cytogenetic band: 10q21.1

UBE2D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2D1 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P060094:  view genomic region     (about GC identifiers)

Start:
60,094,735 bp from pter      End:
60,130,513 bp from pter
Size:
35,779 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 D1  
Size: 147 amino acids; 16602 Da
Subunit: Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X.
Interacts with RNF11
Subcellular location: Cytoplasm
Caution: PubMed:9362508 cloned and sequenced SFT which consisted of UBE2D1 last coding exon along with intronic
sequences on the 5'-end of this exon. A function in iron transport has been described
5 PDB 3D structures from and Proteopedia for UBE2D1:
2C4P (3D)        2YHO (3D)        3OJ4 (3D)        3PTF (3D)        4AP4 (3D)    
Secondary accessions: A6NLF6 A8K786

Explore the universe of human proteins at neXtProt for UBE2D1: NX_P51668

Explore proteomics data for UBE2D1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51668

  • 4/10 DME Specific Peptides for UBE2D1 (P51668) (see all 10)
     CSAGPVG  TKIYHPN  YPFKPPK  QWSPALT 

    UBE2D1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBE2D1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001191809.1  NP_003329.1  

    ENSEMBL proteins: 
     ENSP00000363019  
    Reactome Protein details: P51668
    Human Recombinant Protein Products for UBE2D1: 
    EMD Millipore Purified and/or Recombinant UBE2D1 Protein
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    OriGene Purified Protein for UBE2D1
    OriGene Protein Over-expression Lysate for UBE2D1
    OriGene MassSpec for UBE2D1 
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    Novus Biologicals UBE2D1 Proteins
    Novus Biologicals UBE2D1 Lysate
    Sino Biological Recombinant Protein for UBE2D1
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UBE2D1
    Cloud-Clone Corp. Proteins for UBE2D1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA18845142
    GO:0005829cytosol TAS--

    UBE2D1 for ontologies           About GeneDecksing



    UBE2D1 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR016135 UBQ-conjugating_enzyme/RWD
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2

    Graphical View of Domain Structure for InterPro Entry P51668

    ProtoNet protein and cluster: P51668

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2D1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UB2D1_HUMAN, P51668
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal
    proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and
    auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks
    inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3.
    Mediates polyubiquitination of CYP3A4
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Genatlas biochemistry entry for UBE2D1:
    ubiquitin conjugating enzyme E2D1,homologous to yeast UBC4/5,involved in the degradation of cellular
    proteins,mediating the E6-AP dependent ubiquitination of p53

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA15247280
    GO:0005515protein binding IPI16189514
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2D1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2D1:
     Increased cell death HMECs cel  Synthetic lethal with Ras  Upregulation of NF-kappaB path 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBE2D1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2D1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2D1 

    miRNA
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    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2D1 (see all 39):
    hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-429 hsa-miR-16-1* hsa-miR-301a hsa-miR-3658 hsa-miR-23a hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidUBE2D1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    OriGene RNAi products in human, mouse, rat for UBE2D1
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): UBE2D1 (NM_003338)
    Sino Biological Human cDNA Clone for UBE2D1
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBE2D1 About   (see all 24)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    APC/C:Cdc20 mediated degradation of mitotic proteins0.94
    APC/C:Cdc20 mediated degradation of Securin0.93
    Cdc20:Phospho-APC/C mediated degradation of Cyclin A0.94
    APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G10.93
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Autodegradation of Cdh1 by Cdh1:APC/C0.91
    APC/C-mediated degradation of cell cycle proteins0.94
    Cell Cycle Checkpoints0.58
    2Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.95
    APC/C:Cdc20 mediated degradation of Cyclin B0.76
    Mitotic Spindle Checkpoint0.95
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase0.75
    Inactivation of APC/C via direct inhibition of the APC/C complex0.95
    Phosphorylation of the APC/C0.73
    APC-Cdc20 mediated degradation of Nek2A0.78
    Common schema of ubiquitination0.36
    3Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Ubiquitin mediated proteolysis0.36
    Class I MHC mediated antigen processing & presentation0.83
    4TRAF6 Mediated Induction of proinflammatory cytokines
    Activated TLR4 signalling0.87
    Toll Like Receptor 4 (TLR4) Cascade0.87
    MyD88-independent cascade 0.87
    Toll-Like Receptors Cascades0.87
    Toll Like Receptor 3 (TLR3) Cascade0.87
    TRIF-mediated TLR3/TLR4 signaling 0.86
    5M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for UBE2D1
        Common schema of ubiquitination
    Proteolysis Putative ubiquitin pathway

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2D1
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions

    3 GeneGo (Thomson Reuters) Pathways for UBE2D1
        Regulation of degradation of deltaF508 CFTR in CF
    Proteolysis Putative ubiquitin pathway
    Regulation of degradation of wt-CFTR

    5 BioSystems Pathways for UBE2D1
        TGF-beta Receptor Signaling Pathway
    Proteasome Degradation
    BMP Signalling Pathway
    Internalization of ErbB1
    p53 pathway


    5/53        Reactome Pathways for UBE2D1 (see all 53)
        IKK complex recruitment mediated by RIP1
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    APC/C:Cdc20 mediated degradation of mitotic proteins
    Phosphorylation of the APC/C


    2         Kegg Pathways  (Kegg details for UBE2D1):
        Ubiquitin mediated proteolysis
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668
    Pathway: Protein modification; protein ubiquitination


    UBE2D1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2D1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/189 Interacting proteins for UBE2D1 (P516681, 2, 3 ENSP000003630194) via UniProtKB, MINT, STRING, and/or I2D (see all 189)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000224994Q9HCM92, 3, ENSP000004119494MINT-66353 I2D: score=6 STRING: ENSP00000411949
    ENSG00000232839Q9HCM92, 3, ENSP000003983554MINT-66353 I2D: score=6 STRING: ENSP00000398355
    ENSG00000206495Q9HCM92, 3MINT-66353 I2D: score=6 
    ENSG00000226437Q9HCM92, 3MINT-66353 I2D: score=6 
    ENSG00000229929Q9HCM92, 3MINT-66353 I2D: score=6 
    About this table

    Gene Ontology (GO): 5/24 biological process terms (GO ID links to tree view) (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0000209protein polyubiquitination IDA15247280
    GO:0000278mitotic cell cycle TAS--
    GO:0002224toll-like receptor signaling pathway TAS--
    GO:0002756MyD88-independent toll-like receptor signaling pathway TAS--

    UBE2D1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBE2D1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBE2D1 (UB2D1)

    5 HMDB Compounds for UBE2D1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    IronArmco iron (see all 19)7439-89-6--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    1 Novoseek inferred chemical compound relationship for UBE2D1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 5.22 12 9856986 (6), 12480712 (4)

    Search CenterWatch for drugs/clinical trials and news about UBE2D1 / UB2D1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBE2D1 gene (2 alternative transcripts): 
    NM_001204880.1  NM_003338.4  

    Unigene Cluster for UBE2D1:

    Ubiquitin-conjugating enzyme E2D 1
    Hs.129683  [show with all ESTs]
    Unigene Representative Sequence: NM_003338
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373910(uc001jke.2 uc021prc.1) ENST00000473824 ENST00000606483

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    GenScript: all cDNA clones in your preferred vector (see all 2): UBE2D1 (NM_003338)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2D1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D1
    Sirion Biotech Customized lentivirus for stable overexpression of UBE2D1 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2D1
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    Additional mRNA sequence: 

    AF257220.1 AJ272367.1 AK291901.1 BC005980.1 BC015997.1 BT007041.1 X78140.1 

    6 DOTS entries:

    DT.307663  DT.91814554  DT.121230867  DT.100015092  DT.121230872  DT.91745697 

    24/123 AceView cDNA sequences (see all 123):

    F00283 CR594114 CR619802 AF257220 BM970335 BM721687 AI815985 CA309945 
    CD367095 CA312792 X78140 CR603407 AA310465 AW513111 NM_003338 BG496394 
    CR620939 BM091092 BM091396 AA363510 BQ574761 AI341493 BM467992 BP340354 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
    SP1:              -                       -                           
    SP2:                                      -                           
    SP3:              -           -           -                           
    SP4:                                                                  


    ECgene alternative splicing isoforms for UBE2D1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBE2D1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTCAACT
    UBE2D1 Expression
    About this image


    See UBE2D1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBE2D1

    SOURCE GeneReport for Unigene cluster: Hs.129683

    UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668
    Tissue specificity: Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis

        SABiosciences Expression via Pathway-Focused PCR Array including UBE2D1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2D1 gene from 10/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2d11 , 5 ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog more5
    ubiquitin-conjugating enzyme E2D 11
    89.34(n)1
    100(a)1
      10 (36.85 cM)5
    2160801  NM_145420.21  NP_663395.11 
     712549805 
    chicken
    (Gallus gallus)
    Aves UBE2D11 ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, more 89.8(n)
    100(a)
      423641  NM_001199526.1  NP_001186455.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2D16
    Uncharacterized protein
    100(a)
    1 ↔ 1
    GL343378.1(65756-106443)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.64702 Transcribed sequence with strong similarity to protein more 85.28(n)    142023602 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc16h062 wufc16h06 81.49(n)   324015  BC059465.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta eff3 ubiquitin cycle ubiquitin conjugating
    enzyme
    89(a)
    (best of 3)
      3 88D2   --
    worm
    (Caenorhabditis elegans)
    Secernentea let-703 ubiquitin-conjugating enzyme E2-17 KD 89(a)   IV(11081633-11082511)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC46
    UBC56
    Ubiquitin-conjugating enzyme (E2), mediates degrad...
    Ubiquitin-conjugating enzyme that mediates selecti...
    78(a)
    78(a)
    many ↔ many
    many ↔ many
    II(406628-407169)
    IV(569234-569770)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC81 ubiquitin-conjugating enzyme E2 8 68.25(n)
    75.51(a)
      834173  NM_123535.2  NP_568595.2 
    rice
    (Oryza sativa)
    Liliopsida Os04g06678001 hypothetical protein 67.12(n)
    75.51(a)
      4337331  NM_001060726.1  NP_001054191.1 


    ENSEMBL Gene Tree for UBE2D1 (if available)
    TreeFam Gene Tree for UBE2D1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBE2D1 gene
    UBE2D32  UBE2L62  UBE2D22  UBE2E32  UBE2D42  UBE2L32  UBE2E12  UBE2E22  
    18/30 SIMAP similar genes for UBE2D1 using alignment to 1 protein entry:     UB2D1_HUMAN(see all similar genes):
    UBE2D2    UBE2D4    UBE2D3    UBE2E3    UBE2E1    HR6A
    UBE2DNL    UBE2A    UBE2B    UBE2M    UBE2E2    UBE2L3
    UBE2K    UBE2H    UBE2G2    UBE2N    UBE2G1    UBE2T

    UBE2D1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/615 SNPs in UBE2D1 are shown (see all 615)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs785323561,2
    C,F--60092776(+) TTATGC/TAGTTG 2 -- us2k12Minor allele frequency- T:0.03WA NA 238
    rs1854050031,2
    --60092903(+) TTTTGA/TAAAGC 2 -- us2k10--------
    rs1479792891,2
    C--60093038(+) TCCCAA/TGTAGC 2 -- us2k10--------
    rs1902145741,2
    --60093166(+) CTTGGC/TCTCCA 2 -- us2k10--------
    rs1142574681,2
    C,F--60093258(+) ACCAAC/TGTAGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1826042031,2
    --60093294(+) TTTTGC/TTGGGA 2 -- us2k10--------
    rs1422839211,2
    C--60093613(+) GCTTCA/CCCCAA 2 -- us2k10--------
    rs732863751,2
    C,F--60093838(+) GAGGCC/TACATA 2 -- us2k14Minor allele frequency- T:0.21WA CSA 124
    rs1458805171,2
    --60094066(+) CCAAGA/TTTTAA 2 -- us2k10--------
    rs283658231,2
    C--60094139(+) TGTCAA/GCGGAA 2 -- us2k14Minor allele frequency- G:0.02MN EA NA 1256

    HapMap Linkage Disequilibrium report for UBE2D1 (60094735 - 60130513 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for UBE2D1: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602961    OMIM disorders: --

    20/23 diseases for UBE2D1 (see all 23):    About MalaCards
    nasal cavity neoplasm    spindle cell lipoma    hemochromatosis    lafora disease
    hemangiopericytoma    lipoma    hypoxia    breast cancer susceptibility
    toxoplasmosis    herpes simplex    cytochrome p450    crohn's disease
    psoriasis    meningioma    breast cancer    thyroid cancer
    cystic fibrosis    alzheimer's disease    thyroiditis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for UBE2D1:
    Hemochromatosis

    UBE2D1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for UBE2D1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 0 1 15994932 (1)
    tumors 0 1 12480712 (1)

    Genetic Association Database (GAD): UBE2D1
    Human Genome Epidemiology (HuGE) Navigator: UBE2D1 (2 documents)

    Export disorders for UBE2D1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBE2D1 gene, integrated from 9 sources (see all 284):
    (articles sorted by number of sources associating them with UBE2D1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up- regulated in hereditary hemochromatosis. (PubMed id 12480712)1, 2, 9 Gehrke S.G.... Stremmel W. (2003)
    2. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. (PubMed id 18042044)1, 2, 9 Windheim M....Cohen P. (2008)
    3. The IDOL-UBE2D complex mediates sterol-dependent degr adation of the LDL receptor. (PubMed id 21685362)1, 2 Zhang L....Schwabe J.W. (2011)
    4. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. (PubMed id 19103148)1, 2 Pabarcus M.K....Correia M.A. (2009)
    5. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. (PubMed id 19854139)1, 2 Zeng W....Chen Z.J. (2009)
    6. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. (PubMed id 18845142)1, 2 Espinosa A....Wahren-Herlenius M. (2008)
    7. Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. (PubMed id 18359941)1, 2 Grou C.P....Azevedo J.E. (2008)
    8. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (2007)
    9. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7321 HGNC: 12474 AceView: UBE2D1 Ensembl:ENSG00000072401 euGenes: HUgn7321
    ECgene: UBE2D1 Kegg: 7321 H-InvDB: UBE2D1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBE2D1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2D1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBE2D1 gene:
    Search GeneIP for patents involving UBE2D1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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