Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBE2D1 Gene

Aliases for UBE2D1 Gene

  • Ubiquitin-Conjugating Enzyme E2D 1 2 3
  • Stimulator Of Fe Transport 2 3 4
  • Ubiquitin-Conjugating Enzyme E2D 1 (UBC4/5 Homolog, Yeast) 2 3
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme D1 3 4
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 1 3 4
  • Ubiquitin-Conjugating Enzyme E2(17)KB 1 3 4
  • E2 Ubiquitin-Conjugating Enzyme D1 3 4
  • Ubiquitin Carrier Protein D1 3 4
  • Ubiquitin-Protein Ligase D1 3 4
  • UBC4/5 Homolog 3 4
  • UBCH5A 3 4
  • UBCH5 3 4
  • SFT 3 4
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4
  • E2(17)KB1 3
  • UBC4/5 3
  • UBC5A 4

External Ids for UBE2D1 Gene

Previous HGNC Symbols for UBE2D1 Gene

  • SFT

Previous GeneCards Identifiers for UBE2D1 Gene

  • GC10P058890
  • GC10P059120
  • GC10P059987
  • GC10P059439
  • GC10P059764
  • GC10P060094
  • GC10P054083

Summaries for UBE2D1 Gene

Entrez Gene Summary for UBE2D1 Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

GeneCards Summary for UBE2D1 Gene

UBE2D1 (Ubiquitin-Conjugating Enzyme E2D 1) is a Protein Coding gene. Diseases associated with UBE2D1 include hemochromatosis and hypoxia. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include ligase activity and acid-amino acid ligase activity. An important paralog of this gene is UBE2L6.

UniProtKB/Swiss-Prot for UBE2D1 Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

Gene Wiki entry for UBE2D1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2D1 Gene

Genomics for UBE2D1 Gene

Regulatory Elements for UBE2D1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2D1 Gene

Chromosome:
10
Start:
58,334,975 bp from pter
End:
58,370,753 bp from pter
Size:
35,779 bases
Orientation:
Plus strand

Genomic View for UBE2D1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2D1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2D1 Gene

Proteins for UBE2D1 Gene

  • Protein details for UBE2D1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51668-UB2D1_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 D1
    Protein Accession:
    P51668
    Secondary Accessions:
    • A6NLF6
    • A8K786

    Protein attributes for UBE2D1 Gene

    Size:
    147 amino acids
    Molecular mass:
    16602 Da
    Quaternary structure:
    • Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X. Interacts with RNF11.

    Three dimensional structures from OCA and Proteopedia for UBE2D1 Gene

neXtProt entry for UBE2D1 Gene

Proteomics data for UBE2D1 Gene at MOPED

Selected DME Specific Peptides for UBE2D1 Gene

Post-translational modifications for UBE2D1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2D1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for UBE2D1 (UbcH5a/UBE2D1)

Domains & Families for UBE2D1 Gene

Gene Families for UBE2D1 Gene

Protein Domains for UBE2D1 Gene

Suggested Antigen Peptide Sequences for UBE2D1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51668

UniProtKB/Swiss-Prot:

UB2D1_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2D1: view

Function for UBE2D1 Gene

Molecular function for UBE2D1 Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2D1,homologous to yeast UBC4/5,involved in the degradation of cellular proteins,mediating the E6-AP dependent ubiquitination of p53
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-48-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.

Enzyme Numbers (IUBMB) for UBE2D1 Gene

Gene Ontology (GO) - Molecular Function for UBE2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18359941
GO:0005515 protein binding IPI 16189514
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity --
GO:0061631 ubiquitin conjugating enzyme activity IDA 15247280
genes like me logo Genes that share ontologies with UBE2D1: view
genes like me logo Genes that share phenotypes with UBE2D1: view

Animal Model Products

miRNA for UBE2D1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2D1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for UBE2D1 Gene

Localization for UBE2D1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2D1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2D1 Gene COMPARTMENTS Subcellular localization image for UBE2D1 gene
Compartment Confidence
cytosol 4
nucleus 4
cytoskeleton 2
plasma membrane 2
extracellular 1
vacuole 1

Gene Ontology (GO) - Cellular Components for UBE2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 15247280
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 18845142
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 22797923
genes like me logo Genes that share ontologies with UBE2D1: view

Pathways & Interactions for UBE2D1 Gene

SuperPathways for UBE2D1 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
2 MyD88 cascade initiated on plasma membrane
3 Separation of Sister Chromatids
4 APC-Cdc20 mediated degradation of Nek2A
5 Immune System
genes like me logo Genes that share pathways with UBE2D1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P51668-UB2D1_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2D1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0000209 protein polyubiquitination IDA 15247280
GO:0000278 mitotic cell cycle TAS --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0002224 toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with UBE2D1: view

No data available for SIGNOR curated interactions for UBE2D1 Gene

Drugs & Compounds for UBE2D1 Gene

(4) Drugs for UBE2D1 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Iron Approved Pharma 957
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2D1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
genes like me logo Genes that share compounds with UBE2D1: view

Transcripts for UBE2D1 Gene

Unigene Clusters for UBE2D1 Gene

Ubiquitin-conjugating enzyme E2D 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2D1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - -
SP2: -
SP3: - - -
SP4:

Relevant External Links for UBE2D1 Gene

GeneLoc Exon Structure for
UBE2D1
ECgene alternative splicing isoforms for
UBE2D1

Expression for UBE2D1 Gene

mRNA expression in normal human tissues for UBE2D1 Gene

mRNA differential expression in normal tissues according to GTEx for UBE2D1 Gene

This gene is overexpressed in Whole Blood (x7.6) and Muscle - Skeletal (x6.8).

Protein differential expression in normal tissues from HIPED for UBE2D1 Gene

This gene is overexpressed in Liver (11.9), Breast (10.3), and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBE2D1 Gene



SOURCE GeneReport for Unigene cluster for UBE2D1 Gene Hs.129683

mRNA Expression by UniProt/SwissProt for UBE2D1 Gene

P51668-UB2D1_HUMAN
Tissue specificity: Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis.
genes like me logo Genes that share expression patterns with UBE2D1: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for UBE2D1 Gene

Orthologs for UBE2D1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2D1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2D1 35
  • 96.15 (n)
  • 100 (a)
UBE2D1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2D1 35
  • 97.28 (n)
  • 100 (a)
UBE2D1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2d1 35
  • 89.34 (n)
  • 100 (a)
Ube2d1 16
Ube2d1 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2D1 35
  • 100 (n)
  • 100 (a)
UBE2D1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2d1 35
  • 87.76 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2D1 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2D1 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2D1 35
  • 89.8 (n)
  • 100 (a)
UBE2D1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2D1 36
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6470 35
ube2d1 35
  • 85.26 (n)
  • 95.24 (a)
zebrafish
(Danio rerio)
Actinopterygii ube2d1b 35
  • 81.63 (n)
  • 94.56 (a)
wufc16h06 35
ube2d1b 36
  • 95 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10862 37
  • 52 (a)
CG2574 37
  • 49 (a)
eff 37
  • 89 (a)
worm
(Caenorhabditis elegans)
Secernentea let-70 37
  • 89 (a)
F52C6.12 36
  • 68 (a)
ManyToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBC29 35
  • 66.21 (n)
  • 74.15 (a)
rice
(Oryza sativa)
Liliopsida Os01g0658400 35
  • 68.25 (n)
  • 77.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3943 35
Species with no ortholog for UBE2D1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2D1 Gene

ENSEMBL:
Gene Tree for UBE2D1 (if available)
TreeFam:
Gene Tree for UBE2D1 (if available)

Paralogs for UBE2D1 Gene

Paralogs for UBE2D1 Gene

genes like me logo Genes that share paralogs with UBE2D1: view

Variants for UBE2D1 Gene

Sequence variations from dbSNP and Humsavar for UBE2D1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1905456 -- 58,335,383(-) GTCCG(A/G)TGCCC intron-variant
rs2306605 -- 58,363,234(-) GCCGT(A/C)ATCAG intron-variant
rs3802699 -- 58,368,604(+) TGATA(C/T)ATGTG intron-variant
rs3885750 -- 58,339,876(-) ACTCT(C/T)TCTTA intron-variant
rs4145785 -- 58,362,918(-) AATTT(A/G/T)AAAAA intron-variant

Variation tolerance for UBE2D1 Gene

Residual Variation Intolerance Score: 45.62% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2D1 Gene

HapMap Linkage Disequilibrium report
UBE2D1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for UBE2D1 Gene

Disorders for UBE2D1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for UBE2D1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hemochromatosis
  • hfe hemochromatosis, modifier of
hypoxia
- elite association

Relevant External Links for UBE2D1

Genetic Association Database (GAD)
UBE2D1
Human Genome Epidemiology (HuGE) Navigator
UBE2D1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2D1
genes like me logo Genes that share disorders with UBE2D1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2D1 Gene

Publications for UBE2D1 Gene

  1. Secretory protein with RING finger domain (SPRING) specific to Trypanosoma cruzi is directed, as a ubiquitin ligase related protein, to the nucleus of host cells. (PMID: 19702650) Hashimoto M. … Aoki T. (Cell. Microbiol. 2010) 23 67
  2. Identification of an unconventional E3 binding surface on the UbcH5 ~ Ub conjugate recognized by a pathogenic bacterial E3 ligase. (PMID: 20133640) Levin I. … Brzovic P.S. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  3. Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes. (PMID: 20146531) Graf C. … Mayer M.P. (Biochemistry 2010) 23 67
  4. The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. (PMID: 19240029) Uchiki T. … Goldberg A.L. (J. Biol. Chem. 2009) 23 67
  5. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PMID: 19820702) Garnett M.J. … Venkitaraman A.R. (Nat. Cell Biol. 2009) 23 67

Products for UBE2D1 Gene

Sources for UBE2D1 Gene

Back to Top

Content