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UBE2D1 Gene

protein-coding GIFtS: 68

GC10P059764

ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)
(Previous name: stimulator of Fe transport )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: SFT)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E2(17)KB1 ^¹, ²
EC 6.3.2.19 ^³
OTTHUMP00000019631 ^²
SFT ^², ³
UBC4/5 ^¹, ²
UBCH5 ^¹, ², ³, ⁵
UBCH5A ^², ³, ⁵
UbcH5 ^³
UbcH5A ^¹

Descriptions
E2(17)KB 1 ^³
Stimulator of Fe transport ^¹, ², ³
UBC4/5 homolog ^³
Ubiquitin carrier protein D1 ^³
Ubiquitin-conjugating enzyme E2-17 kDa 1 ^², ³
Ubiquitin-protein ligase D1 ^³
ubiquitin carrier protein ^²
ubiquitin-conjugating enzyme E2D 1 ^²
ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast) ^²

External Ids
HGNC: 12474¹
Entrez Gene: 7321²
UniProtKB: P51668³
Ensembl: ENSG00000072401⁷

Search outside databases for aliases for UBE2D1 gene

Previous GC identifers: GC10P058890 GC10P059120 GC10P059987 GC10P059439

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2D1:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is

up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the

tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by

interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.

[provided by RefSeq]

UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination

of p53/TP53

Gene Wiki entry for UBE2D1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2D1 gene

Entrez Gene cytogenetic band: 10q11.2-q21 Ensembl cytogenetic band: 10q21.1 HGNC cytogenetic band: 10q21.1

UBE2D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10P059764: (about GC identifiers)

Start:	59,764,745 bp from pter
End:	59,800,515 bp from pter
Size:	35,771 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000010.9 NT_008583.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 D1

Size: 147 amino acids; 16602 Da

Subunit: Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC

and TBL1X

Caution: PubMed:9362508 cloned and sequenced SFT which consisted of UBE2D1 last coding exon along

with intronic sequences on the 5'-end of this exon. A function in iron transport has been

described

PDB structures from and Proteopedia :

2C4P (3D)

REFSEQ proteins: NP_003329.1

ENSEMBL proteins:

ENSP00000363019 ENSP00000185885

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBE2D1 Protein
	Sigma-Aldrich Proteins for UBE2D1
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2D1
	Recombinant Proteins from Abcam (UBE2D1)
	Human Recombinant Proteins from Abnova (UBE2D1)

OriGene Purified Recombinant Human Protein: UBE2D1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	EXP	10548110 11340163 15029244
GO:0005829	cytosol	EXP	10793135 11285280 11535616 11742988 12070128

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Antibodies for UBE2D1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of UBE2D1
	Sigma-Aldrich Antibodies for UBE2D1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE2D1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2D1)
	Novus Biologicals Antibodies for UBE2D1

Assays for UBE2D1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2D1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P51668

ProtoNet protein and cluster: P51668

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2D1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2D1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003338

Applied Biosystems Silencer® siRNAs for UBE2D1

Sigma-Aldrich siRNA and siRNA Panels for UBE2D1

Sigma-Aldrich shRNA Panels and shRNA for UBE2D1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003338
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003338
untagged cDNA clone in CMV expression vector: NM_003338

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003338

UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Mediates the selective

degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination

of p53/TP53

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19

Genatlas biochemistry entry for UBE2D1:

ubiquitin conjugating enzyme E2D1,homologous to yeast UBC4/5,involved in the degradation of

cellular proteins,mediating the E6-AP dependent ubiquitination of p53

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2D1 (Your Favorite Gene powered by Ingenuity)

Hypoxia Signaling in the Cardiovascular System
Protein Ubiquitination Pathway

GeneDecks UBE2D1 for the pathways selected above

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UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2D1

5/114 Interacting proteins for UBE2D1 (ENSP00000185885³ P51668²) via UniProtKB, MINT, and/or STRING (see all 114 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000204599	Q9HCM9²	STRING (score=.775) MINT-66353
ENSG00000206495	Q9HCM9²	MINT-66353
RNF126	Q9BV68²	MINT-67066
TRIM39	Q9HCM9²	MINT-66353
XIAP	P98170²	MINT-4543556

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5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000209	protein polyubiquitination	IDA	16275645
GO:0006511	ubiquitin-dependent protein catabolic process	IDA	16275645
GO:0030509	BMP signaling pathway	EXP	15621726
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	EXP	11285280
GO:0031398	positive regulation of protein ubiquitination	IDA	16275645

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2D1
1 Novoseek chemical compound relationship for UBE2D1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	9.17	12	9856986 (6), 12480712 (4)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2D1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2D1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003338

Sigma-Aldrich siRNA and siRNA Panels for UBE2D1

Sigma-Aldrich shRNA Panels and shRNA for UBE2D1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003338

REFSEQ mRNAs for UBE2D1 gene:

NM_003338.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003338

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003338
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003338
                                 untagged cDNA clone in CMV expression vector: NM_003338

Additional cDNA sequence:

AF257220.1 AJ272367.1 AK291901.1 BC005980.1 BC015997.1 BT007041.1 CR594114.1 CR603407.1

CR617065.1 CR619802.1 CR620939.1 X78140.1

6 DOTS entries:

DT.307663 DT.91814554 DT.121230867 DT.100015092 DT.121230872 DT.91745697

24/123 AceView cDNA sequences (see all 123 ):

AW513111 CR617065 BM091396 NM_003338 AJ272367 CR619802 CA309945 CD367058

AA363510 BP340354 F00283 BM091092 CA312792 CD367095 AA310465 BG496394

CR603407 BM467992 BQ574761 AI341493 X78140 CR594114 BM721687 AF257220

highest scoring ESTs for UBE2D1:

AA146924 AA148102 AF257220 AI189220 AI246338 AI474628 AI566662 AI689001 AI800875 AI813597

Unigene Cluster for UBE2D1:

Ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)

Hs.129683 [show with all ESTs]

Unigene Representative Sequence: NM_003338

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D1

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8a	·	8b
SP1:					-								-
SP2:													-
SP3:					-				-				-
SP4:

About this scheme

ECgene alternative splicing isoforms for UBE2D1

2 Ensembl transcripts including schematic representations:

ENST00000373910 ENST00000185885

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2D1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2D1

¹ / ² / ³

6 probe-sets matching UBE2D1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1164_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.91	HG3344-HT3521	0.20	1.00	0.72	1
37826_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.10	AF020761	0.60	1.00	0.82	1
211764_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005980	0.80	1.00	0.91	1
214590_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL545760	0.80	1.00	0.91	1
211764_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214590_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks UBE2D1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATGTCAACT

SOURCE GeneReport for Unigene cluster: Hs.129683
Expression variation in blood from EXPOLDB for UBE2D1
UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668
Tissue specificity: Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary
hemochromatosis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2D1 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2D1¹	--	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, more	97.28(n) 100(a)	608578 XM_845637.1 XP_850730.1
chimpanzee (Pan troglodytes)	UBE2D1¹	--	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, more	100(n) 100(a)	745141 XM_001163868.1 XP_001163868.1
cow (Bos taurus)	UBE2D1¹	--	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, more	96.15(n) 100(a)	535287 NM_001038167.1 NP_001033256.1
rat (Rattus norvegicus)	Ube2d1¹	--	ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog more	87.76(n) 100(a)	361831 XM_342125.3 XP_342126.3
mouse (Mus musculus)	Ube2d1^{1, 5}	10⁵	ubiquitin-conjugating enzyme E2D 1, UBC4/5 homolog more^{1, 5}	89.34(n)¹ 100(a)¹	216080¹ NM_145420.1¹ NP_663395.1¹ AI836420⁵ AK043167⁵ (see all 10)

About this table Species with no ortholog for UBE2D1

ENSEMBL Gene Tree for UBE2D1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2D1 gene

UBE2D3P² UBE2D4² UBE2D2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/120 NCBI SNPs in UBE2D1 are shown (see all 120 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 10 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7067670^1,2	F,H	59800730(+)	`ATTAAG/CCATTA`	1	--	ng3¹		4	EU EA WA	398
	rs7084674^1,2	F,H	59798813(+)	`CAATGC/AAGCTG`	1	--	ut3¹ ese³		4	EU EA WA	420
	rs28365823^1,2	F	59764145(+)	`TGTCAA/GCGGAA`	1	--	ng5¹		2	MN EA	1252
	rs1905455^1,2	A,C,F,H,O	59785229(-)	`TGCTTA/CCCACA`	1	--	int¹		19	NS MN EU EA WA NA	1628
	rs1963927^1,2	A,C,F,H,O	59776841(+)	`ATTAAG/TATTGT`	1	--	int¹		9	MN EU EA WA	1022
	rs10826174^1,2	A,C,F,H	59797416(+)	`GGAGGG/CTCACA`	1	--	int¹		4	EU EA WA	418
	rs11006121^1,2	A,C,F,H	59792072(+)	`AGTTAC/TAGAGT`	1	--	int¹		12	EU EA WA NA	1052
	rs4948291^1,2	A,C,F,H	59770095(+)	`TCTGTC/TTTTAC`	1	--	int¹		13	NS EU EA WA NA	734
	rs10826172^1,2	A,C,F,H	59788687(+)	`CTGCTT/CGGTCC`	1	--	int¹		4	EU EA WA	416
	rs10733980^1,2	A,C,F,H	59777173(+)	`AAAATA/CGATTT`	1	--	int¹		4	EU EA WA	374

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HapMap Linkage Disequilibrium images for UBE2D1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602961

2 Novoseek disease relationships for UBE2D1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	0.00	1	15994932 (1)
tumors	0.00	1	12480712 (1)

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Human Genome Epidemiology Navigator: UBE2D1 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/65 PubMed articles for UBE2D1 gene (see all 65 ):

UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up- regulated in hereditary hemochromatosis. (PubMed id 12480712)^{1, 3, 4} Gehrke S.G.... Stremmel W. (2003)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PubMed id 11389839)^{3, 4} Matsuzawa S. and Reed J.C. (2001)
Assignment of UBE2D1 to human chromosome bands 10q11.2-->q21 by in situ hybridization. (PubMed id 10072594)^{2, 3} Robinson P.A....Markham A.F. (1998)
Functional expression cloning and characterization of SFT, a stimulator of Fe transport. (PubMed id 9362508)^{3, 4} Gutierrez J.A....Wessling-Resnick M. (1997)
Identification of a family of closely related human ubiquitin conjugating enzymes. (PubMed id 8530467)^{2, 3} Jensen J.P....Weissman A.M. (1995)
Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53. (PubMed id 8090726)^{3, 4} Scheffner M.... Howley P.M. (1994)
The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. (PubMed id 18845142)³ Espinosa A....Wahren-Herlenius M. (2008)
Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p. (PubMed id 18644345)³ Williams C....Distel B. (2008)
Identification of phosphorylation sites of TOPORS and a role for serine 98 in the regulation of ubiquitin but not SUMO E3 ligase activity. (PubMed id 19053840)³ Park H.J....Rubin E.H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7321	HGNC: 12474	AceView: UBE2D1	Ensembl:ENSG00000072401	euGenes: HUgn7321
ECgene: UBE2D1	H-InvDB: UBE2D1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for UBE2D1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE2D1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE2D1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2D1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2D1		Antibodies for UBE2D1
	Explore super-pooled esiRNAs		Proteins for UBE2D1
	Lentivirus-delivered shRNAs for UBE2D1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (UBE2D1)

	Tagged/untagged cDNA clones
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	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for UBE2D1

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Antibodies for UBE2D1

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UBE2D1 Gene at Home site.
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UBE2D1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for UBE2D1

Summaries
for UBE2D1

Genomic Location
for UBE2D1

Proteins
for UBE2D1

Protein Domains/
Families
for UBE2D1

Gene Function
for UBE2D1

Pathways & Interactions
for UBE2D1

Drugs & Compounds
for UBE2D1

Transcripts
for UBE2D1

Expression
for UBE2D1

Orthologs
for UBE2D1

Paralogs
for UBE2D1

SNPs/Variants
for UBE2D1

Disorders & Mutations
for UBE2D1

Medical News
for UBE2D1

Publications
for UBE2D1

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Genome Databases showing UBE2D1

Other Databases showing UBE2D1

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Licensable Technologies
for UBE2D1

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for UBE2D1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2D1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor UBE2D1

Summariesfor UBE2D1

Genomic Locationfor UBE2D1

Proteinsfor UBE2D1

Protein Domains/Familiesfor UBE2D1

Gene Functionfor UBE2D1

Pathways & Interactionsfor UBE2D1

Drugs & Compoundsfor UBE2D1

Transcriptsfor UBE2D1

Expression for UBE2D1

Orthologsfor UBE2D1

Paralogsfor UBE2D1

SNPs/Variantsfor UBE2D1

Disorders & Mutationsfor UBE2D1

Medical Newsfor UBE2D1

Publicationsfor UBE2D1

Search for UBE2D1

Genome Databases showing UBE2D1

Other Databases showing UBE2D1

Specialized Databases showing UBE2D1

Licensable Technologiesfor UBE2D1

Servicesfor UBE2D1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2D1

Summaries
for UBE2D1

Genomic Location
for UBE2D1

Proteins
for UBE2D1

Protein Domains/
Families
for UBE2D1

Gene Function
for UBE2D1

Pathways & Interactions
for UBE2D1

Drugs & Compounds
for UBE2D1

Transcripts
for UBE2D1

Expression
for UBE2D1

Orthologs
for UBE2D1

Paralogs
for UBE2D1

SNPs/Variants
for UBE2D1

Disorders & Mutations
for UBE2D1

Medical News
for UBE2D1

Publications
for UBE2D1

Licensable Technologies
for UBE2D1

Services
for UBE2D1