UBE2D1 Gene

Aliases
for UBE2D1 gene

Previous GC identifers: GC10P058890 GC10P059120 GC10P059987 GC10P059439 GC10P059764 GC10P054083

Summaries
for UBE2D1 gene

Genomic Views
for UBE2D1 gene

RefSeq DNA sequence:

NC_000010.10  NC_018921.1  NT_030059.13  

SwitchGear Promoter luciferase reporter plasmid: UBE2D1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2D1

UBE2D1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P060094:  view genomic region     (about GC identifiers)

Proteins
for UBE2D1 gene

5 PDB 3D structures from and Proteopedia for UBE2D1:

2C4P (3D)        2YHO (3D)        3OJ4 (3D)        3PTF (3D)        4AP4 (3D)    

Explore the universe of human proteins at neXtProt for UBE2D1: NX_P51668

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant UBE2D1 Protein
	R&D Systems Recombinant & Natural Proteins for UBE2D1 (UbcH5a/UBE2D1)
	Enzo Life Sciences proteins for UBE2D1
	OriGene Purified Protein: UBE2D1 OriGene Protein Over-expression Lysate: UBE2D1 OriGene Custom Protein Services for UBE2D1
	GenScript Custom Purified and Recombinant Proteins Services for UBE2D1
	Novus Biologicals UBE2D1 Proteins Novus Biologicals UBE2D1 Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for UBE2D1
	Uscn Proteins for UBE2D1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for UBE2D1 (UbcH5a/UBE2D1)
	Browse OriGene Antibodies OriGene Custom Antibody Services for UBE2D1
	GenScript Custom Superior Antibodies Services for UBE2D1
	Novus Biologicals UBE2D1 Antibodies
	Abcam antibodies for UBE2D1
	Uscn Antibodies for UBE2D1
	ThermoFisher Antibody for UBE2D1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for UBE2D1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for UBE2D1

Protein Domains /
Families
for UBE2D1 gene

ProtoNet protein and cluster: P51668

Function
for UBE2D1 gene

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for UBE2D1

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2D1
		8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2D1 (see all 39):
		hsa-miR-142-5p hsa-miR-3607-3p hsa-miR-429 hsa-miR-16-1* hsa-miR-301a hsa-miR-3658 hsa-miR-23a hsa-miR-3148
		SwitchGear 3'UTR luciferase reporter plasmid: UBE2D1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2D1 (see all 7) OriGene shRNA RFP: UBE2D1 OriGene siRNA: UBE2D1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2D1
		Sirion Biotech Custom design and validation of potent shRNA sequences against UBE2D1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for UBE2D1
			Sirion Biotech Customized adenovirus for overexpression of UBE2D1  Sirion Biotech Customized adenovirus for potent knockdown of UBE2D1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2D1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): UBE2D1 (NM_003338)
		Sino Biological Human cDNA Clone for UBE2D1
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2D1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2D1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for UBE2D1
		Search LifeMap BioReagents cell lines for UBE2D1
		Sirion Biotech Customized stable knockdown cell line services for UBE2D1  Sirion Biotech Customized inducible knockdown cell line services for UBE2D1 Sirion Biotech Customized stable overexpressing cell line services for UBE2D1 Sirion Biotech Customized inducible overexpressing cell line services for UBE2D1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D1

Pathways & Interactions
for UBE2D1 gene

	Super-pathway	contained gene-specific pathways
1	Ubiquitinated Orc1 is degraded by the proteasome	8/16 pathways (see all 16) APC/C:Cdh1-mediated degradation of Skp2 0.74 APC/C:Cdc20 mediated degradation of mitotic proteins 0.69 APC/C:Cdc20 mediated degradation of Securin 0.74 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.69 Degradation of multiubiquitinated Securin 0.74 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.68 Autodegradation of Cdh1 by Cdh1:APC/C 0.70 Regulation of APC/C activators between G1/S and early anaphase 0.62
2	APC-Cdc20 mediated degradation of Nek2A	8/10 pathways (see all 10) Degradation of multiubiquitinated Nek2A 1.00 Degradation of multiubiquitinated Cyclin B 0.76 APC-Cdc20 mediated degradation of Nek2A 1.00 Mitotic Spindle Checkpoint 0.75 Inactivation of APC/C via direct inhibition of the APC/C complex 0.78 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.60 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 0.78 Phosphorylation of the APC/C 0.54
3	TRAF6 Mediated Induction of proinflammatory cytokines	TRIF-mediated TLR3/TLR4 signaling 0.73 Activated TLR4 signalling 0.63 MyD88-independent cascade 0.72 Toll Like Receptor 4 (TLR4) Cascade 0.61 Toll Like Receptor 3 (TLR3) Cascade 0.72 Toll-Like Receptors Cascades 0.53
4	M Phase	M Phase 1.00 Mitotic Anaphase 0.85 Mitotic M-M/G1 phases 0.88 Separation of Sister Chromatids 0.80 Mitotic Metaphase and Anaphase 0.85
5	Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha	Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha 1.00 Cellular response to hypoxia 0.72 Cellular responses to stress 0.72 Regulation of Hypoxia-inducible Factor (HIF) by Oxygen 0.72

2 EMD Millipore Pathways for UBE2D1

	Common schema of ubiquitination
	Proteolysis Putative ubiquitin pathway

2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2D1

	Ubiquitin-Proteasome Dependent Proteolysis
	Remodeling of Adherens Junctions

3 GeneGo (Thomson Reuters) Pathways for UBE2D1

	Regulation of degradation of deltaF508 CFTR in CF
	Proteolysis Putative ubiquitin pathway
	Regulation of degradation of wt-CFTR

5 BioSystems Pathways for UBE2D1

	BMP Signalling Pathway
	Proteasome Degradation
	TGF-beta Receptor Signaling Pathway
	Internalization of ErbB1
	p53 pathway

5/62        Reactome Pathways for UBE2D1

	IKK complex recruitment mediated by RIP1
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	APC/C:Cdc20 mediated degradation of mitotic proteins
	Phosphorylation of the APC/C

2         Kegg Pathways  (Kegg details for UBE2D1)

	Ubiquitin mediated proteolysis
	Protein processing in endoplasmic reticulum

UBE2D1 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UBE2D1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/163 Interacting proteins for UBE2D1 (P51668^{1, 2, 3} ENSP00000363019⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 163)

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

Drugs & Compounds
for UBE2D1 gene

Transcripts
for UBE2D1 gene

Expression
for UBE2D1 gene

UBE2D1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATGTCAACT

About this image

UBE2D1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LungLung Bud			Lung
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2D1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2D1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2D1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2D1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D1

Orthologs
for UBE2D1 gene

Paralogs
for UBE2D1 gene

Paralogs for UBE2D1 gene

UBE2D3²  ENSG00000258677²  UBE2L6²  UBE2D2²  UBE2W²  UBE2E3²  UBE2D4²  UBE2E1²  

UBE2L3²  UBE2E2²  

18/30 SIMAP similar genes for UBE2D1 using alignment to 1 protein entry:     UB2D1_HUMAN(see all similar genes):

UBE2D4    UBE2D2    UBE2D3    UBE2E3    UBE2E1    HR6A

UBE2DNL    UBE2A    UBE2L3    UBE2B    UBE2E2    UBE2K

UBE2H    UBE2G2    UBE2M    UBE2N    UBE2G1    UBE2T

UBE2D1 for paralogs           About GeneDecksing

Genomic Variants
for UBE2D1 gene

10/489 NCBI SNPs in UBE2D1 are shown (see all 489)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs785323561,2	C,F	--	60092776(+)	NNNNGC/TAGTTG	2	--	us2k1		2		WA NA	238
rs1854050031,2		--	60092903(+)	TTTTGA/TAAAGC	2	--	us2k1		0	--	--	--	--
rs1479792891,2		--	60093038(+)	TCCCAA/TGTAGC	2	--	us2k1		0	--	--	--	--
rs1902145741,2		--	60093166(+)	CTTGGC/TCTCCA	2	--	us2k1		0	--	--	--	--
rs1142574681,2	C,F	--	60093258(+)	ACCAAC/TGTAGA	2	--	us2k1		1		WA	118
rs1826042031,2		--	60093294(+)	TTTTGC/TTGGGA	2	--	us2k1		0	--	--	--	--
rs1422839211,2	C	--	60093613(+)	GCTTCA/CCCCAA	2	--	us2k1		0	--	--	--	--
rs732863751,2	C,F	--	60093838(+)	GAGGCC/TACATA	2	--	us2k1		4		WA CSA	124
rs1458805171,2		--	60094066(+)	CCAAGA/TTTTAA	2	--	us2k1		0	--	--	--	--
rs283658231,2	C	--	60094139(+)	TGTCAA/GCGGAA	2	--	us2k1		4		MN EA NA	1256

HapMap Linkage Disequilibrium report for UBE2D1 (60094735 - 60130509 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for UBE2D1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2D1

DNA2.0 Custom Variant and Variant Library Synthesis for UBE2D1

Disorders / Diseases
for UBE2D1 gene

20/21 diseases for UBE2D1

2 Novoseek disease relationships for UBE2D1 gene    About this table

Publications
for UBE2D1 gene

PubMed articles for UBE2D1 gene, integrated from 9 sources (see all 258): (articles sorted by number of sources associating them with UBE2D1)

Utopia: connect your pdf to the dynamic world of online information

1. UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up- regulated in hereditary hemochromatosis. (PubMed id 12480712)^{1, 2, 9} Gehrke S.G.... Stremmel W. (2003)
2. Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. (PubMed id 18042044)^{1, 2, 9} Windheim M....Cohen P. (2008)
3. The IDOL-UBE2D complex mediates sterol-dependent degr adation of the LDL receptor. (PubMed id 21685362)^{1, 2} Zhang L....Schwabe J.W. (2011)
4. CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. (PubMed id 19103148)^{1, 2} Pabarcus M.K....Correia M.A. (2009)
5. Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. (PubMed id 19854139)^{1, 2} Zeng W....Chen Z.J. (2009)
6. The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. (PubMed id 18845142)^{1, 2} Espinosa A....Wahren-Herlenius M. (2008)
7. Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. (PubMed id 18359941)^{1, 2} Grou C.P....Azevedo J.E. (2008)
8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
9. The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. (PubMed id 14562029)^{1, 2} Subramaniam V....Seth A. (2003)
10. Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PubMed id 11389839)^{1, 2} Matsuzawa S. and Reed J.C. (2001)

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