UBE2D1 Gene
protein-coding GIFtS : 70
GCID: GC10 P060094
ubiquitin-conjugating enzyme E2D 1 (Previous names: stimulator of Fe transport, ubiquitin-conjugating enzyme... ) (Previous symbol: SFT )
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Aliasesfor UBE2D1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ubiquitin-Conjugating Enzyme E2D 1 1 2 Ubiquitin-Conjugating Enzyme E2(17)KB 12 3 UBCH51 2 3 5 Ubiquitin-Conjugating Enzyme E2-17 KDa 12 3 Stimulator Of Fe Transport1 2 3 Ubiquitin-Protein Ligase D12 3 SFT1 2 3 UBC4/5 Homolog2 3 UBCH5A2 3 5 EC 6.3.2.193 8 E2(17)KB11 2 UbcH5A1 UBC4/51 2 Ubiquitin-Conjugating Enzyme E2 D12 Ubiquitin-Conjugating Enzyme E2D 1 (UBC4/5 Homolog, Yeast)1 2 UBC5A3 Ubiquitin Carrier Protein D12 3 UbcH53
Export aliases for UBE2D1 gene to outside databases Previous GC identifers: GC10P058890 GC10P059120 GC10P059987 GC10P059439 GC10P059764 GC10P054083
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Summariesfor UBE2D1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for UBE2D1 : The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Mar 2011) UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668 Function : Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 Gene Wiki entry for UBE2D1
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Genomic Viewsfor UBE2D1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000010.10 NC_018921.1 NT_030059.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UBE2D1 gene promoter: p53 Tal-1beta Evi-1 E47 HNF-4alpha1 PPAR-alpha c-Myb TGIF Pax-4a En-1 Other transcription factors Search SABiosciences Chromatin IP Primers for UBE2D1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat UBE2D1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 10q21.1 Ensembl cytogenetic band: 10q21.1 HGNC cytogenetic band: 10q21.1 UBE2D1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 10 GeneLoc Exon Structure
GeneLoc location for GC10P060094: view genomic region
(about GC identifiers )
Start:
60,094,735 bp from pter
End:
60,130,509 bp from pter
Size:
35,775 bases
Orientation:
plus strand
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Proteinsfor UBE2D1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668 (See
protein sequence )Recommended Name: Ubiquitin-conjugating enzyme E2 D1 Size : 147 amino acids; 16602 Da
Subunit : Component of a E3 ubiquitin ligase complex containing UBE2D1, SIAH1, CACYBP/SIP, SKP1, APC and TBL1X.Interacts with RNF11
Subcellular location : Cytoplasm
Caution : PubMed:9362508 cloned and sequenced SFT which consisted of UBE2D1 last coding exon along with intronicsequences on the 5'-end of this exon. A function in iron transport has been described
5 PDB 3D structures from and Proteopedia for UBE2D1 :2C4P (3D)
  2YHO (3D)
  3OJ4 (3D)
  3PTF (3D)
  4AP4 (3D)
 
Secondary accessions : A6NLF6 A8K786Explore the universe of human proteins at neXtProt for UBE2D1: NX_P51668 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P51668 4/10 DME Specific Peptides for UBE2D1 (P51668 ) (see all 10 )UBE2D1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins (2 alternative transcripts):
NP_001191809.1 NP_003329.1 ENSEMBL proteins: ENSP00000363019 Reactome Protein details: P51668 Human Recombinant Protein Products for UBE2D1: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
UBE2D1 for ontologies About GeneDecksing UBE2D1 Antibody Products: Assay Products for UBE2D1:
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Protein
Domains / Familiesfor UBE2D1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
UBE2D1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P51668 ProtoNet protein and cluster: P51668
1 Blocks protein family : IPB000608 Ubiquitin-conjugating enzymes UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668 Similarity : Belongs to the ubiquitin-conjugating enzyme family
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Functionfor UBE2D1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: UB2D1_HUMAN, P51668 Function : Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitrocatalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4 Catalytic activity : ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine
Genatlas biochemistry entry for UBE2D1 : ubiquitin conjugating enzyme E2D1,homologous to yeast UBC4/5,involved in the degradation of cellular proteins,mediating the E6-AP dependent ubiquitination of p53 Enzyme Number (IUBMB): EC 6.3.2.19 1 2 Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view) : About this table
UBE2D1 for ontologies About GeneDecksing Phenotypes: 3 GenomeRNAi human phenotypes for UBE2D1 :Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2D1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2D1OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): UBE2D1 (NM_003338 ) Sino Biological Human cDNA Clone for UBE2D1 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2D1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UBE2D1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D1
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Pathways & Interactionsfor UBE2D1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/24 super-pathways (see all 24 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ubiquitinated Orc1 is degraded by the proteasome 2 APC-Cdc20 mediated degradation of Nek2A 3 TRAF6 Mediated Induction of proinflammatory cytokines 4 M Phase 5 Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
Pathway sources See GeneCards unified pathways Show all pathways 2 EMD Millipore Pathways for UBE2D1 2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2D1 3 GeneGo (Thomson Reuters) Pathways for UBE2D1 5 BioSystems Pathways for UBE2D1 5/62
Reactome Pathways for UBE2D1 (see all 62 )2
Kegg Pathways (Kegg details for UBE2D1) :UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668 Pathway : Protein modification; protein ubiquitination
UBE2D1 for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2D1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/163 Interacting proteins for UBE2D1 (P51668 1 , 2 , 3 ENSP00000363019 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 163 )
About this table Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21 ): About this table
UBE2D1 for ontologies About GeneDecksing
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Drugs & Compoundsfor UBE2D1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
UBE2D1 for compounds About GeneDecksing Browse Tocris compounds for UBE2D1 5 HMDB Compounds for UBE2D1 About this table 1 Novoseek chemical compound relationship for UBE2D1 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
iron
5.22
12
9856986 (6), 12480712 (4)
Search CenterWatch for drugs/clinical trials and news about UBE2D1 / UB2D1
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Transcriptsfor UBE2D1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for UBE2D1 gene (2 alternative transcripts): NM_001204880.1 NM_003338.4 Unigene Cluster for UBE2D1:
Ubiquitin-conjugating enzyme E2D 1 Hs.129683 [show with all ESTs ] Unigene Representative Sequence: NM_003338 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000373910 (uc001jke.2 uc021prc.1 ) ENST00000473824 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2D1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2D1OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): UBE2D1 (NM_003338 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBE2D1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UBE2D1
Additional cDNA sequence: AF257220.1 AJ272367.1 AK291901.1 BC005980.1 BC015997.1 BT007041.1 X78140.1
6 DOTS entries : DT.307663 DT.91814554
DT.121230867 DT.100015092 DT.121230872 DT.91745697 24/123 AceView cDNA sequences (see all 123 ):
BM970335 BG496394 AF257220 CA309945 CD679216 CD367095 BM721687 CR617065 BM091092 F00283 CR603407 BM467992 AA363510 CA312792 CD367058 BM091396 BP340354 AW513111 X78140 AA310465 NM_003338 AJ272367 BQ574761 CR619802 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2D1 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b SP1 :     -         -           SP2 :             -           SP3 :     -     -     -           SP4 :                      
ECgene alternative splicing isoforms for UBE2D1
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Expression for UBE2D1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section UBE2D1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TATGTCAACTAbout this image UBE2D1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Lung Lung Bud Lung Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See UBE2D1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UBE2D1 SOURCE GeneReport for Unigene cluster: Hs.129683 UniProtKB/Swiss-Prot: UB2D1_HUMAN, P51668 Tissue specificity : Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis SABiosciences Expression via Pathway-Focused PCR Array including UBE2D1 : Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for UBE2D1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat UBE2D1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat UBE2D1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat UBE2D1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2D1
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Orthologsfor UBE2D1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBE2D1 gene from 8/26 species (see all 26 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
UBE2D11
ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, more
89.8(n) 100(a)
 
423641 NM_001199526.1 NP_001186455.1
lizard (Anolis carolinensis)
Reptilia
UBE2D16
--
100(a)
1 ↔ 1
GL343378.1(65859-106426)
tropical clawed frog (Xenopus tropicalis)
Amphibia
Str.64702
Transcribed sequence with strong similarity to protein more
85.28(n)
 
142023602
zebrafish (Danio rerio)
Actinopterygii
wufc16h062
wufc16h06
81.49(n)
 
324015 BC059465.1
fruit fly (Drosophila melanogaster)
Insecta
eff3
ubiquitin cycle ubiquitin conjugating enzyme
89(a) (best of 3)
 
3 88D2 --
worm (Caenorhabditis elegans)
Secernentea
let-703
ubiquitin-conjugating enzyme E2-17 KD
89(a)
 
IV(11081633-11082511) --
thale cress (Arabidopsis thaliana)
eudicotyledons
UBC81
ubiquitin-conjugating enzyme E2 8
68.25(n) 75.51(a)
 
834173 NM_123535.2 NP_568595.2
rice (Oryza sativa)
Liliopsida
Os04g06678001
hypothetical protein
67.12(n) 75.51(a)
 
4337331 NM_001060726.1 NP_001054191.1
ENSEMBL Gene Tree for UBE2D1 (if available)TreeFam Gene Tree for UBE2D1 (if available)
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Paralogsfor UBE2D1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for UBE2D1 gene UBE2D3 2 ENSG00000258677 2 UBE2L6 2 UBE2D2 2 UBE2W 2 UBE2E3 2 UBE2D4 2 UBE2E1 2 UBE2L3 2 UBE2E2 2 18/30 SIMAP similar genes for UBE2D1 using alignment to 1 protein entry: UB2D1_HUMAN (see all similar genes ):UBE2D4 UBE2D2 UBE2D3 UBE2E3 UBE2E1 HR6A UBE2DNL UBE2A UBE2L3 UBE2B UBE2E2 UBE2K UBE2H UBE2G2 UBE2M UBE2N UBE2G1 UBE2T
UBE2D1 for paralogs About GeneDecksing
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Genomic Variantsfor UBE2D1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 10 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for UBE2D1 (60094735 - 60130509 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for UBE2D1: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing UBE2D1
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Disorders
/ Diseasesfor UBE2D1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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UBE2D1 for disorders About GeneDecksing
OMIM gene information: 602961
OMIM disorders : --20/21 diseases for UBE2D1 (see all 21 ): About MalaCards hemochromatosis nasal cavity neoplasm spindle cell lipoma iron overload lipoma lafora disease breast cancer susceptibility hypoxia herpes simplex hemangiopericytoma breast cancer rheumatoid arthritis toxoplasmosis crohn's disease alzheimer's disease arthritis meningioma pancreatitis malaria neuronitis 1 disease from the University of Copenhagen DISEASES database for UBE2D1 :Hemochromatosis 2 Novoseek disease relationships for UBE2D1 gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer
0
1
15994932 (1)
tumors
0
1
12480712 (1)
Human Genome Epidemiology (HuGE) Navigator: UBE2D1 (2 documents) Export disorders for UBE2D1 gene to outside databases
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Publicationsfor UBE2D1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for UBE2D1 gene, integrated from 9 sources (see all 258 ): (articles sorted by number of sources associating them with UBE2D1) Utopia : connect your pdf to the dynamic world of online information
UbcH5A, a member of human E2 ubiquitin-conjugating enzymes, is closely related to SFT, a stimulator of iron transport, and is up- regulated in hereditary hemochromatosis. (PubMed id 12480712) 1 , 2 , 9 Gehrke S.G.... Stremmel W. (2003) Two different classes of E2 ubiquitin-conjugating enzymes are required for the mono-ubiquitination of proteins and elongation by polyubiquitin chains with a specific topology. (PubMed id 18042044) 1 , 2 , 9 Windheim M....Cohen P. (2008) The IDOL-UBE2D complex mediates sterol-dependent degr adation of the LDL receptor. (PubMed id 21685362) 1 , 2 Zhang L....Schwabe J.W. (2011) CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases. (PubMed id 19103148) 1 , 2 Pabarcus M.K....Correia M.A. (2009) Key role of Ubc5 and lysine-63 polyubiquitination in viral activation of IRF3. (PubMed id 19854139) 1 , 2 Zeng W....Chen Z.J. (2009) The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide. (PubMed id 18845142) 1 , 2 Espinosa A....Wahren-Herlenius M. (2008) Members of the E2D (UbcH5) family mediate the ubiquitination of the conserved cysteine of Pex5p, the peroxisomal import receptor. (PubMed id 18359941) 1 , 2 Grou C.P....Azevedo J.E. (2008) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase. (PubMed id 14562029) 1 , 2 Subramaniam V....Seth A. (2003) Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses. (PubMed id 11389839) 1 , 2 Matsuzawa S. and Reed J.C. (2001)
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External Searches for UBE2D1 gene
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Genome Databases showing UBE2D1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Specialized Databases showing UBE2D1 gene (According to PharmGKB ,
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About This Section Patent Information for UBE2D1 gene: Search GeneIP for patents involving UBE2D1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor UBE2D1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for UBE2D1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for UBE2D1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for UBE2D1 OriGene Protein Over-expression Lysate for UBE2D1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for UBE2D1 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2D1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBE2D1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for UBE2D1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UBE2D1
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