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UBE2CBP Gene

protein-coding   GIFtS: 43

GC06M083659
ubiquitin-conjugating enzyme E2C binding protein
(Previous name: chromosome 6 open reading frame 157 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C6orf157)
Services    

Aliases &
Descriptions
for UBE2CBP

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
C6orf157 2, 3
DKFZp434A1520 1, 2
EC 6.3.2.- 3
H10BH 1, 2, 3, 5
MGC126561 2
MGC126587 2
OTTHUMP00000016787 2
OTTHUMP00000016789 2
YJR141W 1, 2
Descriptions
UBCH10 binding protein with a hect-like domain 2
UbcH10-binding protein with a HECT-like domain 3
chromosome 6 open reading frame 157 1
ubiquitin-conjugating enzyme E2C binding protein 2
External Ids
HGNC: 213811
Entrez Gene: 900252
UniProtKB: Q7Z6J83
Ensembl: ENSG000001184207
Search outside databases for aliases for UBE2CBP gene

Summaries
for UBE2CBP

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UB2CB_HUMAN, Q7Z6J8
Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2
ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their
degradation by the proteasome

Genomic Location
for UBE2CBP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q14.1   Ensembl cytogenetic band:  6q14.1   HGNC cytogenetic band: 6q15

UBE2CBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M083659:     (about GC identifiers)

Start:
 83,658,836 bp from pter
End:
 83,832,269 bp from pter
Size:
 173,434 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000006.10  NT_007299.12  

Proteins
for UBE2CBP

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: UB2CB_HUMAN, Q7Z6J8 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2C-binding protein  
Size: 389 amino acids; 43657 Da
Subunit: Interacts with UBE2C/UbcH10 (E2 ubiquitin-conjugating enzyme). In vitro, interacts with
cyclin B
Subcellular location: Cytoplasm (Potential)
Secondary accessions: B4DP63 Q5T4W2 Q6IPR4 Q75UG0 Q9NT42
Alternative splicing: 2 isoforms:  Q7Z6J8-1   Q7Z6J8-2   

Post-translational modifications:

  • Ubiquitinated by UBCH10 (E2 ubiquitin-conjugating enzyme)1


    • REFSEQ proteins: NP_944602.1  

    ENSEMBL proteins: 
    ENSP00000237186 ENSP00000358762 ENSP00000358764 ENSP00000376653 ENSP00000358761 ENSP00000358760 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: UBE2CBP 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for UBE2CBP: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for UBE2CBP
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for UBE2CBP

    Assays for UBE2CBP: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for UBE2CBP

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR019193 UBQ-conj_enz_E2-bd_prot


       GeneDecks  UBE2CBP for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q7Z6J8

    ProtoNet protein and cluster: Q7Z6J8

    UniProtKB/Swiss-Prot: UB2CB_HUMAN, Q7Z6J8
    Domain: The C-terminal half (AA 188-389) is able to bind cyclin B and shows a self-ubiquitinylation
    activity (mono-, poly, or multi-ubiquitinylation) in a HECT-like sequence dependent manner

    Gene Function
    for UBE2CBP

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (UBE2CBP)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_028218

                  Applied Biosystems Silencer® siRNAs for UBE2CBP

                  Sigma-Aldrich siRNA for UBE2CBP  
                         Sigma-Aldrich shRNA for UBE2CBP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for UBE2CBP
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_198920
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_198920
                                     untagged cDNA clone in CMV expression vector: NM_198920 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_198920

    UniProtKB/Swiss-Prot: UB2CB_HUMAN, Q7Z6J8
    Function: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2
    ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their
    degradation by the proteasome
    Enzyme Number (IUBMB): EC 6.3.2.- 

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016874 ligase activity IEA--
    About this table

    Pathways & Interactions
    for UBE2CBP

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    UniProtKB/Swiss-Prot: UB2CB_HUMAN, Q7Z6J8
    Pathway: Protein modification; protein ubiquitination


    4 Interacting proteins for UBE2CBP (ENSP000002371863) via UniProtKB, MINT, and/or STRING

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2CENSP000003488383STRING (score=.938)
    CCNB2ENSP000002882073STRING (score=.722)
    CCNB3ENSP000003652103STRING (score=.722)
    --ENSP000003702333STRING (score=.722)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019941 modification-dependent protein catabolic process IEA--
    About this table

    Drugs & Compounds
    for UBE2CBP

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for UBE2CBP

    Transcripts
    for UBE2CBP

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (UBE2CBP)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_028218

                  Sigma-Aldrich siRNA for UBE2CBP  
                         Sigma-Aldrich shRNA for UBE2CBP  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_198920  

    REFSEQ mRNAs for UBE2CBP gene: 

    NM_198920.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_198920  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_198920
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_198920
                                     untagged cDNA clone in CMV expression vector: NM_198920 

    Additional cDNA sequence: 

    AB126062.1 AF026526.1 AK298205.1 AL137544.1 BC036049.1 BC053645.1 BC057845.1 BC071763.1 
    BC101512.1 BC101538.1 BC143617.1 CR590287.1 CR598717.1 CR604323.1 

    7 DOTS entries:

    DT.101979664  DT.99962609  DT.86998464  DT.92423695  DT.441685  DT.70101584  DT.40278814 

    24/63 AceView cDNA sequences (see all 63 ):

    AV692609 AA706678 CR590287 AI744564 BQ421993 AI025408 NM_198920 BF438997 
    AI478251 CR598717 CR604323 AW611839 BG150480 AB126062 AW469373 BE552206 
    BU619285 AL137544 AL562253 AI678201 BX489027 BI771255 BI458467 BE777478 

    Unigene Cluster for UBE2CBP:

    Ubiquitin-conjugating enzyme E2C binding protein
    Hs.148609  [show with all ESTs]
    Unigene Representative Sequence: BC036049


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2CBP

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
    SP1:              -                 -                                                   
    SP2:                                -                                                   
    SP3:                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for UBE2CBP

    6 Ensembl transcripts including schematic representations:
    ENST00000237186  ENST00000369747  ENST00000369749  ENST00000392921  ENST00000369746  ENST00000369745  

    Expression
    for UBE2CBP

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    UBE2CBP expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for UBE2CBP

    1 / 2

    6 probe-sets matching UBE2CBP gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    		47581_at2 U95-B 1 0.94 1.00 1.00 1.00 -- -- -- -- --

    		233327_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    		227790_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    		233327_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1569262_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		227790_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TTTCTTTTGT

    SOURCE GeneReport for Unigene cluster: Hs.148609

    Orthologs
    for UBE2CBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for UBE2CBP gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 UBE2CBP1   -- ubiquitin-conjugating enzyme E2C binding protein 87.97(n)
    83.2(a)    		 481900  XM_539021.2  XP_539021.2 
    chimpanzee
    (Pan troglodytes)    		 UBE2CBP1   -- ubiquitin-conjugating enzyme E2C binding protein 98.89(n)
    98.2(a)    		 462851  XM_518608.2  XP_518608.2 
    cow
    (Bos taurus)    		 UBE2CBP1   -- ubiquitin-conjugating enzyme E2C binding protein 83.2(n)
    77.63(a)    		 515386  NM_001075711.1  NP_001069179.1 
    rat
    (Rattus norvegicus)    		 Ube2cbp1   -- ubiquitin-conjugating enzyme E2C binding protein 80.81(n)
    77.13(a)    		 315863  NM_001039610.1  NP_001034699.1 
    mouse
    (Mus musculus)    		 Ube2cbp1, 5 95
    		 ubiquitin-conjugating enzyme E2C binding protein1, 5 82.07(n)1
    78.53(a)1    		 703481  NM_027394.21  NP_081670.11 
     AK0114465  AK0492295  (see all 7)
    About this table        Species with no ortholog for UBE2CBP

    ENSEMBL Gene Tree for UBE2CBP

    Paralogs
    for UBE2CBP

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for UBE2CBP

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/785 NCBI SNPs in UBE2CBP are shown (see all 785 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 277)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs69316521,2
    		A,C,F,H83658514(+) AGATAT/CATCAG 1 -- ng518Minor allele frequency- C:0.28EU EA WA NA 780
    rs1590401,2
    		A,C,F,H83658596(-) TTCCTA/GCTCCA 1 -- ng514Minor allele frequency- G:0.42EU EA WA 420
    rs69137641,2
    		A,C,F,H83658888(+) AATAAC/AAAAAG 1 -- ng514Minor allele frequency- A:0.28EU EA WA 416
    rs64543081,2
    		A,C,F,H83659072(+) ACAGCA/GGTTAA 1 -- ut31 ese34Minor allele frequency- G:0.28EU EA WA 408
    rs77393231,2
    		A,C,F,H83723764(+) ATTCAC/TACGGC 1 V/M mis117Minor allele frequency- T:0.14EU EA WA NA 1496
    rs47069751,2
    		A,C,F,H83659302(+) GAATAC/TATGCA 1 -- ut31 ese34Minor allele frequency- T:0.28EU EA WA 420
    rs125285421,2
    		H83810943(+) ACTGGT/GTCTTA 1 P/T mis14Minor allele frequency- G:0.00EU EA WA 404
    rs66509871,2
    		H83659153(+) CCTTCC/TAGGTG 1 -- ut31 ese34Minor allele frequency- T:0.00EU EA WA 420
    rs37344551,2
    		C,F,H83723885(-) AGACTT/CGTCAG 1 L/L syn1 ese36Minor allele frequency- C:0.01EA EU WA NA 1374
    rs1841331,2
    		A,C,F,H,O83727814(-) AAGTGT/CCTGAC 1 -- int112Minor allele frequency- C:0.27EU EA WA NA 1052
    About this table

    HapMap Linkage Disequilibrium images for UBE2CBP (up to first 250kb)

    Disorders & Mutations
    for UBE2CBP

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 612495

    Medical News
    for UBE2CBP

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for UBE2CBP

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		6 PubMed articles for UBE2CBP gene:

    Search for UBE2CBP

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UBE2CBP

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 90025 HGNC: 21381 AceView: C6orf157 Ensembl:ENSG00000118420 euGenes: HUgn90025
    ECgene: UBE2CBP H-InvDB: UBE2CBP

    Other Databases showing UBE2CBP

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing UBE2CBP

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for UBE2CBP

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for UBE2CBP

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for UBE2CBP:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Predesigned and custom siRNAs for UBE2CBP Antibodies for UBE2CBP
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for UBE2CBP Browse small molecules at Sigma-Aldrich
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