UBE2C Gene

Aliases
for UBE2C gene

Previous GC identifers: GC20P044169 GC20P045079 GC20P045126 GC20P043874 GC20P041183

Summaries
for UBE2C gene

Genomic Views
for UBE2C gene

RefSeq DNA sequence:

NC_000020.10  NC_018931.1  NT_011362.10  

SwitchGear Promoter luciferase reporter plasmids (see all 2): UBE2C promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2C

UBE2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P044442:  view genomic region     (about GC identifiers)

Proteins
for UBE2C gene

1 PDB 3D structure from and Proteopedia for UBE2C:

1I7K (3D)    

Explore the universe of human proteins at neXtProt for UBE2C: NX_O00762

Post-translational modifications:

	EMD Millipore Purified and/or Recombinant UBE2C Protein
	R&D Systems Recombinant & Natural Proteins for UBE2C (UbcH10/UBE2C)
	Enzo Life Sciences proteins for UBE2C
	OriGene Purified Proteins (see all 3): UBE2C OriGene Protein Over-expression Lysate (see all 3): UBE2C OriGene Custom Protein Services for UBE2C
	GenScript Purified and Recombinant Proteins for UBE2C
	Novus Biologicals UBE2C Proteins Novus Biologicals UBE2C Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for UBE2C
	Uscn Proteins for UBE2C

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of UBE2C
	R&D Systems Antibodies for UBE2C (UbcH10/UBE2C)
	OriGene Antibodies: UBE2C OriGene Custom Antibody Services for UBE2C
	GenScript Custom Superior Antibodies Services for UBE2C
	Novus Biologicals UBE2C Antibodies
	Abcam antibodies for UBE2C
	Uscn Antibodies for UBE2C
	ThermoFisher Antibodies for UBE2C

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for UBE2C
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for UBE2C

Protein Domains /
Families
for UBE2C gene

ProtoNet protein and cluster: O00762

Function
for UBE2C gene

Enzyme Number (IUBMB): EC 6.3.2.19^{1 2}

miRNA Products:		OriGene 3'-UTR Clone (see all 5): UBE2C Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2C
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UBE2C
		SwitchGear 3'UTR luciferase reporter plasmid: UBE2C 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2C (see all 7) OriGene shRNA RFP: UBE2C OriGene siRNA: UBE2C
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2C

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for UBE2C

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2C (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2C (see all 7) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): UBE2C (NM_007019)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2C
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2C

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for UBE2C
		Search LifeMap BioReagents cell lines for UBE2C

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2C

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for UBE2C gene

	Super-pathway	contained gene-specific pathways
1	Ubiquitinated Orc1 is degraded by the proteasome	8/15 pathways (see all 15) APC/C:Cdh1-mediated degradation of Skp2 0.74 APC/C:Cdc20 mediated degradation of mitotic proteins 0.69 APC/C:Cdc20 mediated degradation of Securin 0.74 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 0.69 Degradation of multiubiquitinated Securin 0.74 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins 0.68 Autodegradation of Cdh1 by Cdh1:APC/C 0.70 Regulation of APC/C activators between G1/S and early anaphase 0.62
2	APC-Cdc20 mediated degradation of Nek2A	8/10 pathways (see all 10) Degradation of multiubiquitinated Nek2A 1.00 Degradation of multiubiquitinated Cyclin B 0.76 APC-Cdc20 mediated degradation of Nek2A 1.00 Mitotic Spindle Checkpoint 0.75 Inactivation of APC/C via direct inhibition of the APC/C complex 0.78 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 0.60 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 0.78 Phosphorylation of the APC/C 0.54
3	M Phase	M Phase 1.00 Mitotic Anaphase 0.85 Mitotic M-M/G1 phases 0.88 Separation of Sister Chromatids 0.80 Mitotic Metaphase and Anaphase 0.85
4	Antigen processing: Ubiquitination & Proteasome degradation	Antigen processing: Ubiquitination & Proteasome degradation 1.00 Polyubiquitination of substrate 0.75 Class I MHC mediated antigen processing & presentation 0.83 Ubiquitin mediated proteolysis 0.36
5	Immune System	Immune System 1.00 Adaptive Immune System 0.59

1 EMD Millipore Pathway for UBE2C

Common schema of ubiquitination

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2C

	Ubiquitin-Proteasome Dependent Proteolysis
	Remodeling of Adherens Junctions
	SOCS Pathway

5/36        Reactome Pathways for UBE2C

	APC/C:Cdc20 mediated degradation of mitotic proteins
	Phosphorylation of the APC/C
	APC/C:Cdc20 mediated degradation of Securin
	Cdc20:Phospho-APC/C mediated degradation of Cyclin A
	Antigen processing: Ubiquitination & Proteasome degradation

1         Kegg Pathway  (Kegg details for UBE2C)

Ubiquitin mediated proteolysis

UBE2C for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for UBE2C

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/105 Interacting proteins for UBE2C (O00762³ ENSP00000348838⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 105)

Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

Drugs & Compounds
for UBE2C gene

Transcripts
for UBE2C gene

Expression
for UBE2C gene

UBE2C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGCCGAGCT

Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	PureStem™ progenitor E44 (Embryonic Progenitor Cell)
	PureStem™ progenitor F15 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2C Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2C
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2C
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2C

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2C

Orthologs
for UBE2C gene

Paralogs
for UBE2C gene

Paralogs for UBE2C gene

UBE2U²  

18/22 SIMAP similar genes for UBE2C using alignment to 3 protein entries:     UBE2C_HUMAN (see all proteins) (see all similar genes):

HR6A    UBE2A    UBE2U    UBE2B    UBE2H    UBE2D4

UBE2K    UBE2N    UBE2D3    UBE2D2    UBE2D1    UBE2S

UBE2M    UBE2E1    UBE2NL    UBE2W    UBE2T    UBE2E3

UBE2C for paralogs           About GeneDecksing


5 Pseudogenes.org Pseudogenes for UBE2C
PGOHUM00000247755 PGOHUM00000247067 PGOHUM00000234895 PGOHUM00000250630 PGOHUM00000245919

Genomic Variants
for UBE2C gene

10/157 NCBI SNPs in UBE2C are shown (see all 157)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs169907931,2	C,F,	--	44439345(+)	TAAAAG/TATTGT	6	--	us2k1 int1		5		NA WA	256
rs1920397561,2		--	44439392(+)	TCCGTA/GCTAAA	6	--	int1 us2k1		0	--	--	--	--
rs126244281,2	C,H,	--	44439393(+)	CCGTAA/C/TTAAAT	6	--	us2k1 int1		4		NS EA	404
rs799311121,2		--	44439464(+)	GAAGTG/ATTACT	6	--	us2k1 int1		1		WA	118
rs562610481,2	C,F,	--	44439646(+)	AGGCAG/CGGCCT	6	--	us2k1 int1		4		NA WA EU	1563
rs1166536361,2	C,F,	--	44439654(+)	CCTACA/CTCCTC	6	--	int1 us2k1		1		WA	118
rs2004592841,2		--	44439877(+)	AAAGCC/TCTCTT	7	--	ut31 us2k1		0	--	--	--	--
rs61043531,2	C,H	--	44439897(+)	GCTGAG/AGCCAC	7	--	us2k1 ut31		3		NS NA	180
rs1880295271,2		--	44439923(+)	TAGATC/GGATCT	7	--	us2k1 ut31		0	--	--	--	--
rs1405825521,2		--	44440048(+)	TTTGTA/CGTAAA	7	--	ut31 us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for UBE2C (44441215 - 44445596 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for UBE2C: --

SABiosciences Cancer Mutation PCR Assays

1 SABiosciences qBiomarker Copy Number PCR Array containing UBE2C: Ovarian Cancer

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2C

DNA2.0 Custom Variant and Variant Library Synthesis for UBE2C

Disorders / Diseases
for UBE2C gene

18 diseases for UBE2C

3 Novoseek disease relationships for UBE2C gene    About this table

Publications
for UBE2C gene

PubMed articles for UBE2C gene, integrated from 9 sources (see all 113): (articles sorted by number of sources associating them with UBE2C)

Utopia: connect your pdf to the dynamic world of online information

1. Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase. (PubMed id 9122200)^{1, 2, 3, 9} Townsley F.M.... Ruderman J.V. (1997)
2. Identification of a physiological E2 module for the human anaphase- promoting complex. (PubMed id 19822757)^{1, 2} Williamson A....Rape M. (2009)
3. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PubMed id 19820702)^{1, 2} Garnett M.J.... Venkitaraman A.R. (2009)
4. Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. (PubMed id 18485873)^{1, 2} Jin L....Rape M. (2008)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. (PubMed id 11927573)^{1, 2} Lin Y.... Basavappa R. (2002)
7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
8. Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. (PubMed id 17354233)^{1, 9} Ieta K....Mori M. (2007)
9. Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. (PubMed id 17217624)^{1, 9} Lin J....Lin L. (2006)
10. Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. (PubMed id 16772118)^{1, 9} Takahashi Y....Asai S. (2006)

External Searches for UBE2C gene

Genome Databases showing UBE2C gene

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Specialized Databases showing UBE2C gene

Products
for UBE2C gene