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UBE2C Gene(Protein Coding)

Ubiquitin Conjugating Enzyme E2 C

GCID:
GC20P045812
GIFtS:
72
Genes Participants
UDN Logo

Aliases for UBE2C Gene

Aliases for UBE2C Gene

  • Ubiquitin Conjugating Enzyme E2 C 2 3
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme C 3 4
  • E2 Ubiquitin-Conjugating Enzyme C 3 4
  • Ubiquitin-Conjugating Enzyme E2C 2 3
  • Ubiquitin Conjugating Enzyme E2C 3 5
  • Ubiquitin-Protein Ligase C 3 4
  • UBCH10 3 4
  • Mitotic-Specific Ubiquitin-Conjugating Enzyme 3
  • Cyclin-Selective Ubiquitin Carrier Protein 3
  • Ubiquitin Carrier Protein C 4
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • EC 2.3.2.24 4
  • DJ447F3.2 3

External Ids for UBE2C Gene

Previous GeneCards Identifiers for UBE2C Gene

  • GC20P044169
  • GC20P045079
  • GC20P045126
  • GC20P043874
  • GC20P044442
  • GC20P041183

Summaries for UBE2C Gene

Entrez Gene Summary for UBE2C Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

GeneCards Summary for UBE2C Gene

UBE2C (Ubiquitin Conjugating Enzyme E2 C) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and DNA Damage. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2U.

UniProtKB/Swiss-Prot for UBE2C Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating Lys-11-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Gene Wiki entry for UBE2C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2C Gene

Genomics for UBE2C Gene

Products:

  1. Regulatory Element

Regulatory Elements for UBE2C Gene

Enhancers for UBE2C Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2C on UCSC Golden Path with GeneCards custom track

Promoters for UBE2C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2C on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UBE2C gene promoter:

Genomic Location for UBE2C Gene

Chromosome:
20
Start:
45,812,576 bp from pter
End:
45,816,957 bp from pter
Size:
4,382 bases
Orientation:
Plus strand

Genomic View for UBE2C Gene

Genes around UBE2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2C Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UBE2C Gene

Proteins for UBE2C Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for UBE2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00762-UBE2C_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 C
    Protein Accession:
    O00762
    Secondary Accessions:
    • A6NP33
    • E1P5N7
    • G3XAB7

    Protein attributes for UBE2C Gene

    Size:
    179 amino acids
    Molecular mass:
    19652 Da
    Quaternary structure:
    • Component of the APC/C complex.

    Three dimensional structures from OCA and Proteopedia for UBE2C Gene

    Alternative splice isoforms for UBE2C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBE2C Gene

Proteomics data for UBE2C Gene at MOPED

Protein Expression for UBE2C Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for UBE2C Gene

O00762:

Post-translational modifications for UBE2C Gene

  • Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.
  • Ubiquitination at Lys 80 and Lys 121
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2C (UBE2C)

Domains & Families for UBE2C Gene

Gene Families for UBE2C Gene

HGNC:

Protein Domains for UBE2C Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UBE2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00762

UniProtKB/Swiss-Prot:

UBE2C_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2C: view

Function for UBE2C Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for UBE2C Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes Lys-11- and Lys-48-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating Lys-11-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.

Enzyme Numbers (IUBMB) for UBE2C Gene

Gene Ontology (GO) - Molecular Function for UBE2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 contributes_to ubiquitin-protein transferase activity IDA 18485873
genes like me logo Genes that share ontologies with UBE2C: view

Phenotypes for UBE2C Gene

MGI mutant phenotypes for UBE2C:
inferred from 1 alleles
GenomeRNAi human phenotypes for UBE2C:
genes like me logo Genes that share phenotypes with UBE2C: view

Animal Models for UBE2C Gene

MGI Knock Outs for UBE2C:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2C

miRNA for UBE2C Gene

miRTarBase miRNAs that target UBE2C

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2C Gene

Localization for UBE2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2C Gene COMPARTMENTS Subcellular localization image for UBE2C gene
Compartment Confidence
cytosol 5
nucleus 5
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBE2C Gene

Pathways & Interactions for UBE2C Gene

SuperPathways for UBE2C Gene

PathCards logoMore details on SuperPathways for UBE2C
Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins
.95
Cdc20-Phospho-APC/C mediated degradation of Cyclin A
.95
APC/C-Cdc20 mediated degradation of Securin
.93
APC/C-Cdh1 mediated degradation of Cdc20 and other APC/C-Cdh1 targeted proteins in late mitosis/early G1
.93
APC/C-mediated degradation of cell cycle proteins
.93
Regulation of APC/C activators between G1/S and early anaphase
.93
Regulation of mitotic cell cycle
.93
Autodegradation of Cdh1 by Cdh1-APC/C
.91
APC/C-Cdc20 mediated degradation of mitotic proteins
.89
APC-Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
.89
Conversion from APC/C-Cdc20 to APC/C-Cdh1 in late anaphase
1
Phosphorylation of the APC/C
1
2 APC-Cdc20 mediated degradation of Nek2A
APC-Cdc20 mediated degradation of Nek2A
.80
Inactivation of APC/C via direct inhibition of the APC/C complex
.80
APC/C-Cdc20 mediated degradation of Cyclin B
.78
Mitotic Spindle Checkpoint
.77
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
1
3 Antigen processing- Ubiquitination and Proteasome degradation
Antigen processing- Ubiquitination and Proteasome degradation
.85
Class I MHC mediated antigen processing and presentation
.85
Ubiquitin mediated proteolysis
.32
4 Cell Cycle, Mitotic
Cell Cycle
.83
Cell Cycle, Mitotic
.83
M Phase
.61
5 Cellular Senescence
Cellular Senescence
.63
Senescence-Associated Secretory Phenotype (SASP)
.57
Cellular responses to stress
.49
genes like me logo Genes that share pathways with UBE2C: view

UniProtKB/Swiss-Prot O00762-UBE2C_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007094 mitotic spindle assembly checkpoint TAS --
GO:0008054 negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation IDA 9122200
GO:0016567 protein ubiquitination IDA 9122200
GO:0030071 regulation of mitotic metaphase/anaphase transition IBA --
GO:0031536 positive regulation of exit from mitosis IMP 9122200
genes like me logo Genes that share ontologies with UBE2C: view

No data available for SIGNOR curated interactions for UBE2C Gene

Drugs & Compounds for UBE2C Gene

Products:

  1. Drug

(5) Drugs for UBE2C Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
NSC697923 Pharma Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective, Selective UBE2N inhibitor 0

(2) Additional Compounds for UBE2C Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
 7664-38-2

(1) ApexBio Compounds for UBE2C Gene

Compound Action Cas Number
NSC697923 Inhibitor of E2 complex Ubc13-Uev1A,cell permeable and selective 343351-67-7
genes like me logo Genes that share compounds with UBE2C: view

Transcripts for UBE2C Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for UBE2C Gene

(8) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(252) Selected AceView cDNA sequences:
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBE2C Gene

Ubiquitin-conjugating enzyme E2C:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2C Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: -
SP7: - - - - -
SP8:

Relevant External Links for UBE2C Gene

GeneLoc Exon Structure for
UBE2C
ECgene alternative splicing isoforms for
UBE2C

Expression for UBE2C Gene

Products:

  1. Primer

mRNA expression in normal human tissues for UBE2C Gene

mRNA expression in normal human tissues for UBE2C Gene
mRNA expression by BioGPS for UBE2C GenemRNA expression by GTEx for UBE2C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBE2C Gene

This gene is overexpressed in Esophagus - Mucosa (x5.0).

Protein differential expression in normal tissues from HIPED for UBE2C Gene

This gene is overexpressed in Bone (41.7) and Stomach (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2C Gene



SOURCE GeneReport for Unigene cluster for UBE2C Gene Hs.93002

genes like me logo Genes that share expression patterns with UBE2C: view

Protein tissue co-expression partners for UBE2C Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for UBE2C Gene

Orthologs for UBE2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia UBE2C 35
  • 91.43 (n)
  • 97.21 (a)
UBE2C 36
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia UBE2C 35
  • 93.11 (n)
  • 97.77 (a)
UBE2C 36
  • 98 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ube2c 35
  • 87.52 (n)
  • 95.53 (a)
Ube2c 16
Ube2c 36
  • 96 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia UBE2C 35
  • 99.44 (n)
  • 100 (a)
-- 36
  • 100 (a)
 OneToMany
-- 36
  • 100 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Ube2c 35
  • 89.76 (n)
  • 96.09 (a)
oppossum
(Monodelphis domestica)
 Mammalia UBE2C 36
  • 93 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia UBE2C 36
  • 70 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves UBE2C 35
  • 78.41 (n)
  • 88.57 (a)
UBE2C 36
  • 73 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ube2c 35
  • 72.47 (n)
  • 79.78 (a)
zebrafish
(Danio rerio)
 Actinopterygii ube2c 35
  • 68.44 (n)
  • 76.92 (a)
ube2c 36
  • 37 (a)
 OneToOne
rainbow trout
(Oncorhynchus mykiss)
 Actinopterygii Omy.8806 35
fruit fly
(Drosophila melanogaster)
 Insecta vihar 37
  • 66 (a)
vih 35
  • 65.5 (n)
  • 66.43 (a)
vih 36
  • 56 (a)
 OneToOne
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP006238 35
  • 61.3 (n)
  • 60.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes UBC11 35
  • 56.25 (n)
  • 63.28 (a)
UBC11 36
  • 52 (a)
 OneToMany
UBC11 38
thale cress
(Arabidopsis thaliana)
 eudicotyledons UBC19 35
  • 58.9 (n)
  • 59.51 (a)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.9379 35
barley
(Hordeum vulgare)
 Liliopsida Hv.2165 35
rice
(Oryza sativa)
 Liliopsida Os.247 35
Os01g0273100 35
  • 64.2 (n)
  • 62.35 (a)
wheat
(Triticum aestivum)
 Liliopsida Ta.3436 35
sea squirt
(Ciona intestinalis)
 Ascidiacea Cin.5287 35
fission yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ubc11 35
  • 52.32 (n)
  • 56.97 (a)
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.3903 36
  • 60 (a)
 OneToOne
Species with no ortholog for UBE2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • worm (Caenorhabditis elegans)

Evolution for UBE2C Gene

ENSEMBL:
Gene Tree for UBE2C (if available)
TreeFam:
Gene Tree for UBE2C (if available)

Paralogs for UBE2C Gene

Paralogs for UBE2C Gene

(23) SIMAP similar genes for UBE2C Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for UBE2C Gene

genes like me logo Genes that share paralogs with UBE2C: view

Variants for UBE2C Gene

Sequence variations from dbSNP and Humsavar for UBE2C Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
VAR_007694 -
rs440789 -- 45,812,854(+) ACCCA(C/G)AGCAA intron-variant, upstream-variant-2KB
rs445503 -- 45,817,430(-) TCCAC(A/C/T)GGGGA downstream-variant-500B
rs1711193 -- 45,814,271(-) tatat(A/G)cccac intron-variant
rs1711194 -- 45,814,269(-) TATGC(C/T)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2C Gene

Variant ID Type Subtype PubMed ID
nsv833990 CNV Loss 17160897

Variation tolerance for UBE2C Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2C Gene

HapMap Linkage Disequilibrium report
UBE2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2C Gene

Disorders for UBE2C Gene

Relevant External Links for UBE2C

Genetic Association Database (GAD)
UBE2C
Human Genome Epidemiology (HuGE) Navigator
UBE2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2C

No disorders were found for UBE2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2C Gene

Publications for UBE2C Gene

  1. Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase. (PMID: 9122200) Townsley F.M. … Ruderman J.V. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23 67
  2. Knockdown of ubiquitin-conjugating enzyme E2C/UbcH10 expression by RNA interference inhibits glioma cell proliferation and enhances cell apoptosis in vitro. (PMID: 19657671) Jiang L. … Lu Y. (J. Cancer Res. Clin. Oncol. 2010) 3 23
  3. Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. (PMID: 20065091) van Ree J.H. … van Deursen J.M. (J. Cell Biol. 2010) 3 23
  4. Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors. (PMID: 18331723) Jiang L. … Han H.X. (Brain Res. 2008) 3 23
  5. Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. (PMID: 17354233) Ieta K. … Mori M. (Int. J. Cancer 2007) 3 23

Products for UBE2C Gene

  • Addgene plasmids for UBE2C

Sources for UBE2C Gene

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