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UBE2C Gene

protein-coding GIFtS: 63

GC20P043874

ubiquitin-conjugating enzyme E2C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
EC 6.3.2.19 ^³
OTTHUMP00000031653 ^²
OTTHUMP00000031655 ^²
UBCH10 ^¹, ², ³, ⁵
UbcH10 ^³
dJ447F3.2 ^²

Descriptions
Ubiquitin carrier protein C ^³
Ubiquitin-protein ligase C ^², ³
cyclin-selective ubiquitin carrier protein ^²
mitotic-specific ubiquitin-conjugating enzyme ^²
ubiquitin carrier protein E2-C ^²
ubiquitin-conjugating enzyme E2C ^²

External Ids
HGNC: 15937¹
Entrez Gene: 11065²
UniProtKB: O00762³
Ensembl: ENSG00000175063⁷

Search outside databases for aliases for UBE2C gene

Previous GC identifers: GC20P044169 GC20P045079 GC20P045126

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for UBE2C:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle

progression. Multiple transcript variants encoding different isoforms have been found for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Required for the

destruction of mitotic cyclins

Gene Wiki entry for UBE2C

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2C gene

Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q13.12

UBE2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P043874: (about GC identifiers)

Start:	43,874,662 bp from pter
End:	43,879,003 bp from pter
Size:	4,342 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 C

Size: 179 amino acids; 19652 Da

PDB structures from and Proteopedia :

1I7K (3D)

REFSEQ proteins (6 alternative transcripts):

NP_008950.1 NP_861515.1 NP_861516.1 NP_861517.1 NP_861518.1 NP_861519.1

ENSEMBL proteins:

ENSP00000243893 ENSP00000335674 ENSP00000333975 ENSP00000348838 ENSP00000361649 ENSP00000361660

ENSP00000385878

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBE2C Protein
	Sigma-Aldrich Proteins for UBE2C
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2C
	Recombinant Proteins from Abcam (UBE2C)
	Human Recombinant Proteins from Abnova (UBE2C)

OriGene Purified Recombinant Human Proteins (see all 2): UBE2C

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	EXP	10548110 11340163 15029244
GO:0005829	cytosol	EXP	10793135 11285280 11535616 11742988 12070128

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Antibodies for UBE2C:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of UBE2C
	Sigma-Aldrich Antibodies for UBE2C
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (UBE2C), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2C)
	Novus Biologicals Antibodies for UBE2C

Assays for UBE2C:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2C

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O00762

ProtoNet protein and cluster: O00762

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2C)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_181799

Applied Biosystems Silencer® siRNAs for UBE2C

Sigma-Aldrich siRNA and siRNA Panels for UBE2C

Sigma-Aldrich shRNA Panels and shRNA for UBE2C

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2C
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_007019
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_007019
untagged cDNA clones in CMV expression vector (see all 7): NM_007019

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_007019

UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Required for the

destruction of mitotic cyclins

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IDA	9122200
GO:0005524	ATP binding	IEA	--
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2C (Your Favorite Gene powered by Ingenuity)

Protein Ubiquitination Pathway
Hypoxia Signaling in the Cardiovascular System

GeneDecks UBE2C for the pathways selected above

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UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2C

5/72 Interacting proteins for UBE2C (ENSP00000348838³) via UniProtKB, MINT, and/or STRING (see all 72 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	ENSP00000344818³	STRING (score=.981)
PTTG2	ENSP00000344936³	STRING (score=.968)
ANAPC2	ENSP00000314004³	STRING (score=.959)
ANAPC11	ENSP00000349957³	STRING (score=.955)
CDC27	ENSP00000066544³	STRING (score=.949)

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5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006511	ubiquitin-dependent protein catabolic process	IDA	9122200
GO:0007049	cell cycle	NAS	15504738
GO:0007051	spindle organization	NAS	15504738
GO:0007067	mitosis	IEA	--
GO:0008054	cyclin catabolic process	IDA	9122200

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2C
2 Novoseek chemical compound relationships for UBE2C gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	21.92	1	14732013 (1)
oligonucleotide	14.41	1	17217624 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2C)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2C)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_181799

Sigma-Aldrich siRNA and siRNA Panels for UBE2C

Sigma-Aldrich shRNA Panels and shRNA for UBE2C

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_007019 NM_181799 NM_181800 NM_181801 NM_181802 NM_181803

REFSEQ mRNAs for UBE2C gene (6 alternative transcripts):

NM_007019.2 NM_181799.1 NM_181800.1 NM_181801.2 NM_181802.1 NM_181803.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_007019 NM_181799 NM_181800 NM_181801 NM_181802 NM_181803

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_007019
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_007019
                                 untagged cDNA clones in CMV expression vector (see all 7): NM_007019

Additional cDNA sequence:

AK311949.1 BC007656.2 BC016292.1 BC028161.1 BC032677.2 BC050736.1 BT007300.1 BT020165.1

BT020166.1 CR456988.1 CR593952.1 CR610834.1 U73379.1

17 DOTS entries:

DT.455083 DT.446076 DT.101984847 DT.91766689 DT.95092516 DT.101984846 DT.100822418 DT.120817240

DT.120817711 DT.102842123 DT.102842126 DT.120817606 DT.102842114 DT.120817859 DT.95189185 DT.95245584

DT.100038110

24/252 AceView cDNA sequences (see all 252 ):

BM845270 BM549174 BU625723 BI870709 BU509336 BE268039 BU844974 BU727867

AI250679 BX344527 BM698699 NM_181800 AI264541 BQ218554 BE904898 NM_007019

BC016292 BU506804 BM755952 AA596035 BM467729 BU509084 BM781915 CR610834

highest scoring ESTs for UBE2C:

U73379 AA136118 AA149943 AA160710 AA305922 AA382274 AA401483 AA403150 AA430504 AA554943

Unigene Cluster for UBE2C:

Ubiquitin-conjugating enzyme E2C

Hs.93002 [show with all ESTs]

Unigene Representative Sequence: BC032677

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2C (see all 8 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b
SP1:							-		-				-
SP2:							-		-						-
SP3:							-		-				-		-
SP4:							-		-		-				-
SP5:							-		-		-		-

About this scheme

ECgene alternative splicing isoforms for UBE2C

7 Ensembl transcripts including schematic representations:

ENST00000243893 ENST00000335046 ENST00000352551 ENST00000356455 ENST00000372568 ENST00000372579

ENST00000405520

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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UBE2C expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2C

¹ / ² / ³

3 probe-sets matching UBE2C gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1651_at²^{, 3}	U95-A	3	1.00	0.89	1.00	1.00	U73379	1.00	1.00	1.00	1
202954_at²^{, 3}	U133-A	3	1.00	0.94	--	--	NM_007019	0.60	1.00	0.82	1
202954_at²	U133Plus2	3	1.00	0.94	--	--	--	--	--	--	--

GeneDecks UBE2C for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTGCCGAGCT

SOURCE GeneReport for Unigene cluster: Hs.93002
Expression variation in blood from EXPOLDB for UBE2C

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2C gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2C¹	--	ubiquitin-conjugating enzyme E2C	93.11(n) 97.77(a)	485898 XM_543022.2 XP_543022.2
cow (Bos taurus)	UBE2C¹	--	ubiquitin-conjugating enzyme E2C	91.43(n) 97.21(a)	506962 NM_001037449.1 NP_001032526.1
rat (Rattus norvegicus)	Ube2c¹	--	ubiquitin-conjugating enzyme E2C	89.76(n) 96.09(a)	296368 XM_215924.3 XP_215924.1
mouse (Mus musculus)	Ube2c^{1, 5}	2 (93.00 cM)⁵	ubiquitin-conjugating enzyme E2C^{1, 5}	87.52(n)¹ 95.53(a)¹	68612¹ NM_026785.2¹ NP_081061.1¹ AK003722⁵ AK136186⁵ (see all 14)
zebrafish (Danio rerio)	zgc:123190¹	--	zgc:123190	68.64(n) 76.92(a)	566441 NM_001037691.1 NP_001032780.1

About this table Species with no ortholog for UBE2C

ENSEMBL Gene Tree for UBE2C

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2C gene

UBE2B² UBE2A²

Pseudogenes

3 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/68 NCBI SNPs in UBE2C are shown (see all 68 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 47)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs6104355^1,2	A,C,F,H	43879083(+)	`AAGCAG/ATGGGG`	6	--	ng3¹		8		EU EA WA	822
	rs368622^1,2	A,C,H	43874097(-)	`acgtcT/Cgtaat`	6	--	ng5¹		4		EU EA WA	418
	rs445503^1,2	A,F,H	43879476(-)	`TCCACC/AGGGGA`	6	--	ng3¹		5		EA NA EU WA	268
	rs440789^1,2	C,F,H	43874900(+)	`ACCCAG/CAGCAA`	6	--	int¹ ng5¹ ut5¹ ese³		12		MN EU EA WA NA	1082
	rs6130939^1,2	H	43879066(+)	`CTTAAG/AGATGT`	6	--	ng3¹		4		EU EA WA	420
--	rs6094213^1,2	H	43874133(+)	`ATGTTG/TCCTTT`	6	--	ng5¹		4		EU EA WA	394
	rs11537645^1,2	C	43874810(-)	`CCCCCG/CCTCGG`	6	R/S	mis¹ ng5¹ ut5¹ ese³		1		NA	72
	rs7352110^1,2	H	43877755(+)	`ATGTCA/GGGACC`	6	R/G	mis¹ int¹ ese³		4		EU EA WA	418
	rs382494^1,2	C,F,H	43878167(-)	`AAATTA/GTTTAT`	6	--	int¹		5		MN EU EA WA	604
--	rs910396^1,2	A,C	43877173(-)	`GGGCGC/TGGTGG`	6	--	int¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for UBE2C (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 605574

3 Novoseek disease relationships for UBE2C gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
primary tumor	18.82	2	16772118 (1)
tumors	0.00	7	18331723 (1), 17354233 (1), 17217624 (1), 16772118 (1)
metastasis	0.00	1	16772118 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/50 PubMed articles for UBE2C gene (see all 50 ):

Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase. (PubMed id 9122200)^{1, 2, 3, 4} Townsley F.M.... Ruderman J.V. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. (PubMed id 11927573)^{3, 4} Lin Y.... Basavappa R. (2002)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. (PubMed id 17354233)^{1, 3} Ieta K....Mori M. (2007)
Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. (PubMed id 17217624)^{1, 3} Lin J....Lin L. (2006)
Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH. (PubMed id 16772118)^{1, 3} Takahashi Y....Asai S. (2006)
Expression of ubiquitin-conjugating enzyme E2C/UbcH10 in astrocytic tumors. (PubMed id 18331723)^{1, 3} Jiang L....Han H.X. (2008)
Analysis of UbcH10 expression represents a useful tool for the diagnosis and therapy of astrocytic tumors. (PubMed id 18666437)³ Donato G....Fusco A. (2008)
Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma. (PubMed id 18753363)³ Lee J.J....Larsson C. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 11065	HGNC: 15937	AceView: UBE2C	Ensembl:ENSG00000175063	euGenes: HUgn11065
ECgene: UBE2C	H-InvDB: UBE2C

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for UBE2C	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBE2C
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for UBE2C:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2C-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2C		Antibodies for UBE2C
	Explore super-pooled esiRNAs		Proteins for UBE2C
	Lentivirus-delivered shRNAs for UBE2C		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (UBE2C)

	Tagged/untagged cDNA clones
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	shRNA in GFP-retroviral vector

Search Tocris compounds for UBE2C

	Assays/Proteins for UBE2C
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for UBE2C

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UBE2C Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for UBE2C

Summaries
for UBE2C

Genomic Location
for UBE2C

Proteins
for UBE2C

Protein Domains/
Families
for UBE2C

Gene Function
for UBE2C

Pathways & Interactions
for UBE2C

Drugs & Compounds
for UBE2C

Transcripts
for UBE2C

Expression
for UBE2C

Orthologs
for UBE2C

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for UBE2C

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Genome Databases showing UBE2C

Other Databases showing UBE2C

Specialized Databases showing UBE2C

Licensable Technologies
for UBE2C

Services
for UBE2C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2C Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor UBE2C

Summariesfor UBE2C

Genomic Locationfor UBE2C

Proteinsfor UBE2C

Protein Domains/Familiesfor UBE2C

Gene Functionfor UBE2C

Pathways & Interactionsfor UBE2C

Drugs & Compoundsfor UBE2C

Transcriptsfor UBE2C

Expression for UBE2C

Orthologsfor UBE2C

Paralogsfor UBE2C

SNPs/Variantsfor UBE2C

Disorders & Mutationsfor UBE2C

Medical Newsfor UBE2C

Publicationsfor UBE2C

Search for UBE2C

Genome Databases showing UBE2C

Other Databases showing UBE2C

Specialized Databases showing UBE2C

Licensable Technologiesfor UBE2C

Servicesfor UBE2C

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2C

Summaries
for UBE2C

Genomic Location
for UBE2C

Proteins
for UBE2C

Protein Domains/
Families
for UBE2C

Gene Function
for UBE2C

Pathways & Interactions
for UBE2C

Drugs & Compounds
for UBE2C

Transcripts
for UBE2C

Expression
for UBE2C

Orthologs
for UBE2C

Paralogs
for UBE2C

SNPs/Variants
for UBE2C

Disorders & Mutations
for UBE2C

Medical News
for UBE2C

Publications
for UBE2C

Licensable Technologies
for UBE2C

Services
for UBE2C