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UBE2C Gene

protein-coding   GIFtS: 69
GCID: GC20P044442

Ubiquitin-Conjugating Enzyme E2C

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2C1 2     dJ447F3.22
UBCH102 3 5     Mitotic-Specific Ubiquitin-Conjugating Enzyme2
Ubiquitin-Protein Ligase C2 3     Ubiquitin-Conjugating Enzyme E2 C2
EC 6.3.2.193 8     UbcH103
Cyclin-Selective Ubiquitin Carrier Protein2     Ubiquitin Carrier Protein C3

External Ids:    HGNC: 159371   Entrez Gene: 110652   Ensembl: ENSG000001750637   OMIM: 6055745   UniProtKB: O007623   

Export aliases for UBE2C gene to outside databases

Previous GC identifers: GC20P044169 GC20P045079 GC20P045126 GC20P043874 GC20P041183


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2C Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a
member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of
mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript
variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on
chromosomes 4, 14, 15, 18, and 19. (provided by RefSeq, Aug 2013)

GeneCards Summary for UBE2C Gene:
UBE2C (ubiquitin-conjugating enzyme E2C) is a protein-coding gene. Diseases associated with UBE2C include papillary thyroid carcinoma, and intrahepatic cholangiocarcinoma. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is ENSG00000258677.

UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting
complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.
Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C
substrates by the proteasome and promoting mitotic exit

Gene Wiki entry for UBE2C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2C gene promoter:
         c-Rel   Pax-2   CP1A   CP1C   Pax-2a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): UBE2C promoter sequence
   Search Chromatin IP Primers for UBE2C

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

UBE2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2C gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P044442:  view genomic region     (about GC identifiers)

Start:
44,441,215 bp from pter      End:
44,445,596 bp from pter
Size:
4,382 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 C  
Size: 179 amino acids; 19652 Da
Subunit: Component of the APC/C complex
1 PDB 3D structure from and Proteopedia for UBE2C:
1I7K (3D)    
Secondary accessions: A6NP33 E1P5N7 G3XAB7
Alternative splicing: 4 isoforms:  O00762-1   O00762-2   O00762-3   O00762-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBE2C: NX_O00762

Explore proteomics data for UBE2C at MOPED

Post-translational modifications: 

  • Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a
    central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit
    the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates
    have been destroyed1
  • Ubiquitination2 at Lys80, Lys121
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for UBE2C (O00762)
     ICLDILK  QSLLGEPN  GTVYEDLRYKLSLEFPSGYPYNAPTVKF  VGKRLQQELMTLMMSGDKGISAFPESDNLFKW 


    See UBE2C Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001268670.1  NP_001268671.1  NP_008950.1  NP_861515.1  NP_861516.1  NP_861517.1  

    ENSEMBL proteins: 
     ENSP00000348838   ENSP00000335674   ENSP00000243893   ENSP00000333975   ENSP00000361649  
     ENSP00000385878  
    Reactome Protein details: O00762

    UBE2C Human Recombinant Protein Products:

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    Novus Biologicals UBE2C Proteins
    Novus Biologicals UBE2C Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBE2C
    Cloud-Clone Corp. Proteins for UBE2C

    UBE2C Antibody Products:

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    UBE2C Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for UBE2C
    Cloud-Clone Corp. CLIAs for UBE2C


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    UBE2: Ubiquitin-conjugating enzymes E2

    3 InterPro protein domains:
     IPR023313 UBQ-conjugating_AS
     IPR000608 UBQ-conjugat_E2
     IPR016135 UBQ-conjugating_enzyme/RWD

    Graphical View of Domain Structure for InterPro Entry O00762

    ProtoNet protein and cluster: O00762

    1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

    UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762
    Similarity: Belongs to the ubiquitin-conjugating enzyme family


    UBE2C for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBE2C_HUMAN, O00762
    Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro
    catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting
    complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis.
    Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C
    substrates by the proteasome and promoting mitotic exit
    Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

         Enzyme Number (IUBMB): EC 6.3.2.191 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842contributes to ubiquitin-protein ligase activity IDA18485873
    GO:0005515protein binding IPI19822757
    GO:0005524ATP binding IEA--
    GO:0016881acid-amino acid ligase activity ----
         
    UBE2C for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for UBE2C:
     Decreased cilium length after   Decreased viability  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Ube2c (no phenotypes)

    UBE2C for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ube2ctm1(KOMP)Wtsi for UBE2C

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBE2C
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBE2C

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBE2C
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBE2C

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBE2C:
    hsa-mir-671-5p (MIRT039262), hsa-mir-16-5p (MIRT031394), hsa-mir-140-3p (MIRT021680), hsa-mir-196a-5p (MIRT048197), hsa-mir-615-3p (MIRT040327), hsa-mir-193b-3p (MIRT016310), hsa-mir-20a-5p (MIRT050549), hsa-mir-17-5p (MIRT050874), hsa-mir-24-3p (MIRT030369)

    Block miRNA regulation of human, mouse, rat UBE2C using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UBE2C
    SwitchGear 3'UTR luciferase reporter plasmidUBE2C 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat UBE2C

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    GenScript: all cDNA clones in your preferred vector (see all 6): UBE2C (NM_007019)
    Sino Biological Human cDNA Clone for UBE2C
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2C
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2C

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2C


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005680anaphase-promoting complex IDA18485873
    GO:0005829cytosol TAS--

    UBE2C for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBE2C About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Inactivation of APC/C via direct inhibition of the APC/C complex
    Inactivation of APC/C via direct inhibition of the APC/C complex0.64
    Mitotic Spindle Checkpoint0.62
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components0.64
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35
    3CDK-mediated phosphorylation and removal of Cdc6
    APC/C-mediated degradation of cell cycle proteins0.94
    Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins0.92
    Regulation of mitotic cell cycle0.94
    Autodegradation of Cdh1 by Cdh1-APC/C0.91
    Regulation of APC/C activators between G1/S and early anaphase0.94
    Cell Cycle Checkpoints0.58
    APC/C-Cdc20 mediated degradation of Securin0.93
    Phosphorylation of the APC/C0.00
    4Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    5Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2C
        Ubiquitin-Proteasome Dependent Proteolysis
    Remodeling of Adherens Junctions
    SOCS Pathway

    2 BioSystems Pathways for UBE2C
        Gastric cancer network 1
    Gastric cancer network 2


    Selected Reactome Pathways for UBE2C (see all 12)
        APC/C:Cdc20 mediated degradation of mitotic proteins
    Autodegradation of Cdh1 by Cdh1:APC/C
    Phosphorylation of the APC/C
    Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
    APC/C:Cdc20 mediated degradation of Securin


    1 Kegg Pathway  (Kegg details for UBE2C):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: UBE2C_HUMAN, O00762
    Pathway: Protein modification; protein ubiquitination


    UBE2C for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2C: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for UBE2C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBE2C (O007623 ENSP000003488384) via UniProtKB, MINT, STRING, and/or I2D (see all 118)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANAPC11Q9NYG53, ENSP000003499574I2D: score=1 STRING: ENSP00000349957
    PCGF3Q3KNV83, ENSP000003547244I2D: score=1 STRING: ENSP00000354724
    POLMQ9NP873, ENSP000002422484I2D: score=1 STRING: ENSP00000242248
    RANBP9Q96S593, ENSP000000116194I2D: score=1 STRING: ENSP00000011619
    UBASH3BQ8TF423, ENSP000002842734I2D: score=1 STRING: ENSP00000284273
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006511ubiquitin-dependent protein catabolic process IDA18485873
    GO:0007049cell cycle NAS15504738
    GO:0007051spindle organization NAS15504738
    GO:0007094mitotic spindle assembly checkpoint TAS--

    UBE2C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBE2C

    4 HMDB Compounds for UBE2C    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 Novoseek inferred chemical compound relationships for UBE2C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 19.1 1 14732013 (1)
    oligonucleotide 11.8 1 17217624 (1)



    UBE2C for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBE2C gene (8 alternative transcripts): 
    NM_001281741.1  NM_001281742.1  NM_007019.3  NM_181799.2  NM_181800.2  NM_181801.3  NM_181802.1  NM_181803.1  

    Unigene Cluster for UBE2C:

    Ubiquitin-conjugating enzyme E2C
    Hs.93002  [show with all ESTs]
    Unigene Representative Sequence: BC032677
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356455(uc002xpm.3 uc002xpo.3 uc002xpp.3) ENST00000335046(uc002xpl.3)
    ENST00000243893 ENST00000352551 ENST00000372568(uc002xpq.3) ENST00000496085
    ENST00000405520(uc002xpn.3)
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2C
      QuantiTect SYBR Green Assays in human, mouse, rat UBE2C
      QuantiFast Probe-based Assays in human, mouse, rat UBE2C

    Additional mRNA sequence: 

    AK311949.1 BC007656.2 BC016292.1 BC028161.1 BC032677.2 BC050736.1 BT007300.1 BT020165.1 
    BT020166.1 CR456988.1 U73379.1 

    17 DOTS entries:

    DT.455083  DT.446076  DT.101984847  DT.91766689  DT.95092516  DT.101984846  DT.100822418  DT.120817240 
    DT.120817711  DT.102842123  DT.102842126  DT.120817606  DT.102842114  DT.120817859  DT.95189185  DT.95245584 
    DT.100038110 

    Selected AceView cDNA sequences (see all 252):

    BM556795 BM467729 CA429608 BM423477 BI870709 BE268039 BC007656 BC028161 
    BM557700 BE797203 BC050736 BX344527 BQ218554 BQ676468 BU509336 CR610834 
    BM755952 BM845270 AI264541 BU625723 BM781915 BC016292 BM698699 BU844974 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBE2C (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b
    SP1:                    -     -           -                           
    SP2:                    -     -                 -                     
    SP3:                    -     -           -     -                     
    SP4:                    -     -     -           -                     
    SP5:                    -     -     -     -                           


    ECgene alternative splicing isoforms for UBE2C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBE2C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCGAGCT
    UBE2C Expression
    About this image


    UBE2C expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Double Negative 2 Thymocytes Thymus
             Bone marrow-derived hematopoietic stem cells (family)
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
    UBE2C Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBE2C Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.93002
        Pathway & Disease-focused RT2 Profiler PCR Array including UBE2C: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBE2C gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ube2c1 , 5 ubiquitin-conjugating enzyme E2C1, 5 87.52(n)1
    95.53(a)1
      2 (85.27 cM)5
    686121  NM_026785.21  NP_081061.11 
     1647698985 
    chicken
    (Gallus gallus)
    Aves UBE2C1 ubiquitin-conjugating enzyme E2C 78.41(n)
    88.57(a)
      100859413  XM_003642470.2  XP_003642518.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia 480179322   -- 77.83(n)    48017932 
    zebrafish
    (Danio rerio)
    Actinopterygii ube2c1 ubiquitin-conjugating enzyme E2C 68.44(n)
    76.92(a)
      566441  NM_001037691.2  NP_001032780.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta vihar3
    vih1
    ubiquitin conjugating enzyme3
    vihar1
    66(a)3
    65.5(n)1
    66.43(a)1
      69C43
    441181  NM_140325.31  NP_648582.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBC11(YOR339C)4
    UBC111
    Ubiquitin-conjugating enzyme most similar in sequence more4
    UBC111
    56.25(n)1
    63.28(a)1
      15(958832-958362)4
    8545171, 4  NP_014984.31  NP_014984.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBC191 UBC19 58.9(n)
    59.51(a)
      821545  NM_112897.3  NP_566653.1 
    rice
    (Oryza sativa)
    Liliopsida Os.2472 Oryza sativa (japonica cultivar-group) cDNA clone0 more 75.21(n)    AK105320.1 


    ENSEMBL Gene Tree for UBE2C (if available)
    TreeFam Gene Tree for UBE2C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBE2C gene
    ENSG000002586772  UBE2W2  
    Selected SIMAP similar genes for UBE2C using alignment to 3 protein entries:     UBE2C_HUMAN (see all proteins) (see all similar genes):
    HR6A    UBE2A    UBE2U    UBE2B    UBE2H    UBE2D4
    UBE2K    UBE2N    UBE2D3    UBE2D2    UBE2D1    UBE2S
    UBE2M    UBE2NL    UBE2E1    UBE2W    UBE2E3    CDC34

    UBE2C for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for UBE2C
    PGOHUM00000247755 PGOHUM00000247067 PGOHUM00000234895 PGOHUM00000250630 PGOHUM00000245919


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBE2C (see all 183)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894151611,2
    --44440630(+) CTGGTA/CTCGAA 6 -- us2k10--------
    rs81229731,2
    C,F--44440635(+) ctcgaT/Actcct 6 -- us2k12Minor allele frequency- A:0.33WA CSA 3
    rs3686221,2
    C,F,A,H--44440690(-) ACGTCT/CGTAAT 6 -- us2k115Minor allele frequency- C:0.15NS EA WA NA CSA 791
    rs60942131,2
    H--44440726(+) ATGTTG/TCCTTT 6 -- us2k14Minor allele frequency- T:0.00NS EA 394
    rs731247411,2
    C,F--44440737(+) TTTTAT/CTTCTG 6 -- us2k13Minor allele frequency- C:0.03NA WA 240
    rs739111131,2
    C,F--44440990(+) AGAAGG/AAGGGG 6 -- us2k12Minor allele frequency- A:0.03WA 120
    rs1813039071,2
    --44441088(+) CAGCAG/TCATCT 6 -- us2k10--------
    rs731247421,2
    C,F--44441090(+) GCATCA/GTCTAC 6 -- us2k13Minor allele frequency- G:0.02NA WA 240
    rs1838159931,2
    --44441175(+) AATAGA/GGCGCT 6 -- us2k10--------
    rs751694541,2
    C--44441237(+) ACGCCC/TCCAGA 6 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBE2C (44441215 - 44445596 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBE2C:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833990CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing UBE2C:
    Ovarian Cancer
    SeqTarget long-range PCR primers for resequencing UBE2C
    DNA2.0 Custom Variant and Variant Library Synthesis for UBE2C

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605574    OMIM disorders: --

    19 diseases for UBE2C:    
    About MalaCards
    papillary thyroid carcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma    pancreatic ductal adenocarcinoma
    cervical cancer    neuroblastoma    cervicitis    esophagitis
    thyroiditis    lung adenocarcinoma    hepatocellular carcinoma    lung cancer
    adenocarcinoma    colorectal cancer    malaria    prostate cancer
    prostatitis    breast cancer    pancreatitis


    UBE2C for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for UBE2C gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    primary tumor 15.8 2 16772118 (1)
    tumors 6.27 15 20065091 (4), 20099376 (4), 18331723 (1), 17217624 (1) (see all 6)
    metastasis 0 1 16772118 (1)

    Genetic Association Database (GAD): UBE2C
    Human Genome Epidemiology (HuGE) Navigator: UBE2C (3 documents)

    Export disorders for UBE2C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBE2C gene, integrated from 10 sources (see all 130):
    (articles sorted by number of sources associating them with UBE2C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase. (PubMed id 9122200)1, 2, 3, 9 Townsley F.M.... Ruderman J.V. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. Identification of a physiological E2 module for the human anaphase- promoting complex. (PubMed id 19822757)1, 2 Williamson A....Rape M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    4. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PubMed id 19820702)1, 2 Garnett M.J.... Venkitaraman A.R. (Nat. Cell Biol. 2009)
    5. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)1, 2 Jin L.... Rape M. (Cell 2008)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. (PubMed id 11927573)1, 2 Lin Y.... Basavappa R. (J. Biol. Chem. 2002)
    8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    9. Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. (PubMed id 17354233)1, 9 Ieta K....Mori M. (Int. J. Cancer 2007)
    10. Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. (PubMed id 17217624)1, 9 Lin J....Lin L. (Neoplasia 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11065 HGNC: 15937 AceView: UBE2C Ensembl:ENSG00000175063 euGenes: HUgn11065
    ECgene: UBE2C Kegg: 11065 H-InvDB: UBE2C

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBE2C Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBE2C Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBE2C gene:
    Search GeneIP for patents involving UBE2C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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