UBE2C Gene

Aliases
for UBE2C gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC20P044169 GC20P045079 GC20P045126 GC20P043874 GC20P041183

Summaries
for UBE2C gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for UBE2C gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000020.10  NC_018931.2  NT_011362.11  

SwitchGear Promoter luciferase reporter plasmids (see all 2): UBE2C promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2C

UBE2C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P044442:  view genomic region     (about GC identifiers)

Proteins
for UBE2C gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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1 PDB 3D structure from and Proteopedia for UBE2C:

1I7K (3D)    

Explore the universe of human proteins at neXtProt for UBE2C: NX_O00762

Explore proteomics data for UBE2C at MOPED

Post-translational modifications: 

UBE2C Human Recombinant Protein Products:

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	antibodies-online proteins for UBE2C (32 products)
	antibodies-online peptides for UBE2C

UBE2C Antibody Products:

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UBE2C Assay Products:

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	antibodies-online kits for UBE2C (13 products)

Domains /
Families
for UBE2C gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: O00762

Find genes that share domains with UBE2C           About GenesLikeMe

Function
for UBE2C gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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     Enzyme Number (IUBMB): EC 6.3.2.19^{1 2}

     Gene Ontology (GO): 4 molecular function terms:    About this table

genOway: Develop your customized and physiologically relevant rodent model for UBE2C

miRNA Products:		miRTarBase miRNAs that target UBE2C: hsa-mir-671-5p (MIRT039262), hsa-mir-16-5p (MIRT031394), hsa-mir-140-3p (MIRT021680), hsa-mir-196a-5p (MIRT048197), hsa-mir-615-3p (MIRT040327), hsa-mir-193b-3p (MIRT016310), hsa-mir-20a-5p (MIRT050549), hsa-mir-17-5p (MIRT050874), hsa-mir-24-3p (MIRT030369)
		Block miRNA regulation of human, mouse, rat UBE2C using miScript Target Protectors
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		SwitchGear 3'UTR luciferase reporter plasmid: UBE2C 3' UTR sequence

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		Predesigned siRNA for gene silencing in human, mouse, rat UBE2C

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for UBE2C

Clone Products:		OriGene clones in human, mouse for UBE2C (see all 34) OriGene ORF clones in mouse, rat for UBE2C OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		Sino Biological Human cDNA Clone for UBE2C
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		Addgene plasmids for UBE2C

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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2C

Flow Cytometry Products:

eBioscience FlowRNA Probe Sets ( VA1-10346) for UBE2C

Localization
for UBE2C gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
nucleus	5
cytosol	4
cytoskeleton	1
endoplasmic reticulum	1
mitochondrion	1
peroxisome	1
plasma membrane	1

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Gene Ontology (GO): 3 cellular component terms:    About this table

Pathways & Interactions
for UBE2C gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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SuperPaths for UBE2C About   (see all 11)   See pathways by source

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	SuperPath	Selected contained pathways About (see all per SuperPath)
1	Class I MHC mediated antigen processing and presentation	Class I MHC mediated antigen processing and presentation 0.84 Adaptive Immune System 0.41 Antigen processing- Ubiquitination and Proteasome degradation 0.84 Ubiquitin mediated proteolysis 0.35
2	CDK-mediated phosphorylation and removal of Cdc6	APC/C-mediated degradation of cell cycle proteins 0.94 Activation of APC/C and APC/C-Cdc20 mediated degradation of mitotic proteins 0.92 Regulation of mitotic cell cycle 0.94 Autodegradation of Cdh1 by Cdh1-APC/C 0.91 Regulation of APC/C activators between G1/S and early anaphase 0.94 Cell Cycle Checkpoints 0.58 APC/C-Cdc20 mediated degradation of Securin 0.93 Phosphorylation of the APC/C 0.00
3	Inactivation of APC/C via direct inhibition of the APC/C complex	Inactivation of APC/C via direct inhibition of the APC/C complex 0.64 APC/C-Cdc20 mediated degradation of Cyclin B 0.64 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components 0.64 Mitotic Spindle Checkpoint 0.62
4	Mitotic Metaphase and Anaphase	Separation of Sister Chromatids 0.94 Mitotic Metaphase and Anaphase 0.93 Mitotic Anaphase 0.94
5	Cell Cycle, Mitotic	Cell Cycle, Mitotic 0.90 M Phase 0.62 Cell Cycle 0.90

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2C

	Ubiquitin-Proteasome Dependent Proteolysis
	Remodeling of Adherens Junctions
	SOCS Pathway

2 BioSystems Pathways for UBE2C

	Gastric cancer network 1
	Gastric cancer network 2

Selected Reactome Pathways for UBE2C

	APC/C:Cdc20 mediated degradation of mitotic proteins
	Autodegradation of Cdh1 by Cdh1:APC/C
	Phosphorylation of the APC/C
	Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
	APC/C:Cdc20 mediated degradation of Securin

1 Kegg Pathway  (Kegg details for UBE2C)

Ubiquitin mediated proteolysis

    Pathway & Disease-focused RT² Profiler PCR Array including UBE2C: 

Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

Drugs & Compounds
for UBE2C gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for UBE2C gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for UBE2C gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UBE2C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: CTGCCGAGCT

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Blood (Cardiovascular System)    fully expand to see all 3 entries
Double Negative 2 Thymocytes Thymus
Bone marrow-derived hematopoietic stem cells (family)
Thymus (Hematopoietic System)
Double Negative 2 Thymocytes Thymus

Primer Products:		OriGene qPCR primer pairs and template standards for UBE2C OriGene qSTAR qPCR primer pairs in human, mouse for UBE2C
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2C

Orthologs
for UBE2C gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for UBE2C gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for UBE2C gene

ENSG00000258677²  UBE2W²  

Selected SIMAP similar genes for UBE2C using alignment to 3 protein entries:     UBE2C_HUMAN (see all proteins) (see all similar genes):

HR6A    UBE2A    UBE2U    UBE2B    UBE2H    UBE2D4

UBE2K    UBE2N    UBE2D3    UBE2D2    UBE2D1    UBE2S

UBE2M    UBE2NL    UBE2E1    UBE2W    UBE2E3    CDC34

Find genes that share paralogs with UBE2C           About GenesLikeMe


5 Pseudogenes.org Pseudogenes for UBE2C
PGOHUM00000247755 PGOHUM00000247067 PGOHUM00000234895 PGOHUM00000250630 PGOHUM00000245919

Genomic Variants
for UBE2C gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UBE2C (see all 183)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1894151611,2		--	44440630(+)	CTGGTA/CTCGAA	6	--	us2k1		0	--	--	--	--
rs81229731,2	C,F	--	44440635(+)	ctcgaT/Actcct	6	--	us2k1		2		WA CSA	3
rs3686221,2	C,F,A,H	--	44440690(-)	ACGTCT/CGTAAT	6	--	us2k1		15		NS EA WA NA CSA	791
rs60942131,2	H	--	44440726(+)	ATGTTG/TCCTTT	6	--	us2k1		4		NS EA	394
rs731247411,2	C,F	--	44440737(+)	TTTTAT/CTTCTG	6	--	us2k1		3		NA WA	240
rs739111131,2	C,F	--	44440990(+)	AGAAGG/AAGGGG	6	--	us2k1		2		WA	120
rs1813039071,2		--	44441088(+)	CAGCAG/TCATCT	6	--	us2k1		0	--	--	--	--
rs731247421,2	C,F	--	44441090(+)	GCATCA/GTCTAC	6	--	us2k1		3		NA WA	240
rs1838159931,2		--	44441175(+)	AATAGA/GGCGCT	6	--	us2k1		0	--	--	--	--
rs751694541,2	C	--	44441237(+)	ACGCCC/TCCAGA	6	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for UBE2C (44441215 - 44445596 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for UBE2C:    About this table    

Variant ID	Type	Subtype	PubMed ID
nsv833990	CNV	Loss	17160897

Site Specific Mutation Identification with PCR Assays

1 Copy Number PCR Panel containing UBE2C: Ovarian Cancer

SeqTarget long-range PCR primers for resequencing UBE2C

DNA2.0 Custom Variant and Variant Library Synthesis for UBE2C

Disorders / Diseases
for UBE2C gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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3 Novoseek inferred disease relationships for UBE2C gene    About this table

Publications
for UBE2C gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for UBE2C gene, integrated from 10 sources (see all 130): (articles sorted by number of sources associating them with UBE2C)

Utopia: connect your pdf to the dynamic world of online information

1. Dominant-negative cyclin-selective ubiquitin carrier protein E2- C/UbcH10 blocks cells in metaphase. (PubMed id 9122200)^{1, 2, 3, 9} Townsley F.M.... Ruderman J.V. (Proc. Natl. Acad. Sci. U.S.A. 1997)
2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)^{1, 4} Bailey S.D....Anand S. (Diabetes Care 2010)
3. Identification of a physiological E2 module for the human anaphase- promoting complex. (PubMed id 19822757)^{1, 2} Williamson A....Rape M. (Proc. Natl. Acad. Sci. U.S.A. 2009)
4. UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. (PubMed id 19820702)^{1, 2} Garnett M.J.... Venkitaraman A.R. (Nat. Cell Biol. 2009)
5. Mechanism of ubiquitin-chain formation by the human anaphase- promoting complex. (PubMed id 18485873)^{1, 2} Jin L.... Rape M. (Cell 2008)
6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S.... Malek J. (Genome Res. 2004)
7. Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10. (PubMed id 11927573)^{1, 2} Lin Y.... Basavappa R. (J. Biol. Chem. 2002)
8. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (Nature 2001)
9. Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression. (PubMed id 17354233)^{1, 9} Ieta K....Mori M. (Int. J. Cancer 2007)
10. Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma. (PubMed id 17217624)^{1, 9} Lin J....Lin L. (Neoplasia 2006)

External Searches for UBE2C gene

Genome Databases showing UBE2C gene

Other Databases showing UBE2C gene

Specialized Databases showing UBE2C gene

Products
for UBE2C gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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