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UBE2B Gene

protein-coding   GIFtS: 70
GCID: GC05P133706

Ubiquitin-Conjugating Enzyme E2B

(Previous name: ubiquitin-conjugating enzyme E2B (RAD6 homolog))
  See UBE2B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin-Conjugating Enzyme E2B1 2     EC 6.3.2.193 8
RAD6B2 3 5     E2-17kDa2
Ubiquitin-Conjugating Enzyme E2B (RAD6 Homolog)1 2     HHR6B2
Ubiquitin Carrier Protein B2 3     UBC22
Ubiquitin-Conjugating Enzyme E2-17 KDa2 3     E2 Protein2
Ubiquitin-Protein Ligase B2 3     Ubiquitin-Conjugating Enzyme E2 B2
HR6B2 3     hHR6B3
RAD6 Homolog B2 3     

External Ids:    HGNC: 124731   Entrez Gene: 73202   Ensembl: ENSG000001190487   OMIM: 1790955   UniProtKB: P631463   

Export aliases for UBE2B gene to outside databases

Previous GC identifers: GC05P133355 GC05P134221 GC05P133737 GC05P133783 GC05P133734 GC05P128891


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBE2B Gene:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or
short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes:
ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or
E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for
post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit
homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. (provided by RefSeq, Jul
2008)

GeneCards Summary for UBE2B Gene:
UBE2B (ubiquitin-conjugating enzyme E2B) is a protein-coding gene. Diseases associated with UBE2B include male infertility. GO annotations related to this gene include ubiquitin-protein ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2S.

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In
association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by
catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag
for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a
prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and
'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3
ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated
PCNA on 'Lys-164'. May be involved in neurite outgrowth

Gene Wiki entry for UBE2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_034772.7  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBE2B gene promoter:
         COUP-TF1   GR   Sp1   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   ARP-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBE2B promoter sequence
   Search Chromatin IP Primers for UBE2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBE2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

UBE2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P133706:  view genomic region     (about GC identifiers)

Start:
133,706,870 bp from pter      End:
133,727,799 bp from pter
Size:
20,930 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 B  
Size: 152 amino acids; 17312 Da
Subunit: Interacts with RAD18, UBR2 and WAC
5 PDB 3D structures from and Proteopedia for UBE2B:
1JAS (3D)        1NXA (3D)        2Y4W (3D)        2YB6 (3D)        2YBF (3D)    
Secondary accessions: B2R503 D3DQA2 P23567 Q4PJ15 Q9D0J6

Explore the universe of human proteins at neXtProt for UBE2B: NX_P63146

Explore proteomics data for UBE2B at MOPED

Selected DME Specific Peptides for UBE2B (P63146) (see all 13)
 SKMFHPN  CLDILQN  MFHPNVY  AAQLYQEN 


See UBE2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_003328.1  
ENSEMBL proteins: 
 ENSP00000265339   ENSP00000425237   ENSP00000426364   ENSP00000425137  
Reactome Protein details: P63146

UBE2B Human Recombinant Protein Products:

EMD Millipore Purified and/or Recombinant UBE2B Protein
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OriGene Protein Over-expression Lysate for UBE2B
OriGene MassSpec for UBE2B
OriGene Custom Protein Services for UBE2B
GenScript Purified and Recombinant Proteins for UBE2B
Novus Biologicals UBE2B Proteins
Novus Biologicals UBE2B Lysates
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates
ProSpec Recombinant Protein for UBE2B
Cloud-Clone Corp. Proteins for UBE2B

 
Search eBioscience for Proteins for UBE2B 

 
antibodies-online proteins for UBE2B (24 products) 

 
antibodies-online peptides for UBE2B

UBE2B Antibody Products:

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Novus Biologicals UBE2B Antibodies
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antibodies-online antibodies for UBE2B (38 products) 

UBE2B Assay Products:

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Cloud-Clone Corp. ELISAs for UBE2B
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Search eBioscience for ELISAs for UBE2B 
antibodies-online kits for UBE2B (9 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
UBE2: Ubiquitin-conjugating enzymes E2

3 InterPro protein domains:
 IPR023313 UBQ-conjugating_AS
 IPR000608 UBQ-conjugat_E2
 IPR016135 UBQ-conjugating_enzyme/RWD

Graphical View of Domain Structure for InterPro Entry P63146

ProtoNet protein and cluster: P63146

1 Blocks protein domain: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146
Similarity: Belongs to the ubiquitin-conjugating enzyme family


Find genes that share domains with UBE2B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: UBE2B_HUMAN, P63146
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In
association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by
catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag
for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a
prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and
'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3
ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated
PCNA on 'Lys-164'. May be involved in neurite outgrowth
Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

     Genatlas biochemistry entry for UBE2B:
ubiquitin conjugating enzyme E2B,involved in post replication repair,containing a CGG repeat in 5'utr

     Enzyme Number (IUBMB): EC 6.3.2.191 2

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity IMP18339854
GO:0005515protein binding IPI12776193
GO:0005524ATP binding IEA--
GO:0016881acid-amino acid ligase activity ----
GO:0031625ubiquitin protein ligase binding IPI10908344
     
Find genes that share ontologies with UBE2B           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for UBE2B:
 Decreased number of cells in m  Increased circadian period len 

     8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ube2b):
 cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism 
 immune system  mortality/aging  reproductive system 

Find genes that share phenotypes with UBE2B           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Ube2btm1Jhjh for UBE2B

   genOway: Develop your customized and physiologically relevant rodent model for UBE2B

miRNA
Products:
    
miRTarBase miRNAs that target UBE2B:
hsa-mir-101-3p (MIRT027247)

Block miRNA regulation of human, mouse, rat UBE2B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate UBE2B (see all 87):
hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-519a hsa-miR-3161 hsa-miR-890 hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidUBE2B 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for UBE2B
Predesigned siRNA for gene silencing in human, mouse, rat UBE2B

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for UBE2B

Clone
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OriGene clones in human, mouse for UBE2B (see all 6)
OriGene ORF clones in mouse, rat for UBE2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UBE2B (NM_003337)
Sino Biological Human cDNA Clone for UBE2B
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2B
Addgene plasmids for UBE2B 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for UBE2B
Browse ESI BIO Cell Lines and PureStem Progenitors for UBE2B 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2B


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
UBE2B_HUMAN, P63146: Cell membrane (By similarity). Nucleus (By similarity). Note=In peripheral neurons,
expressed both at the plasma membrane and in nuclei (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5
plasma membrane5
cytosol2
endoplasmic reticulum1
mitochondrion1

Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000785chromatin ISS--
GO:0000790nuclear chromatin IEA--
GO:0001741XY body IEA--
GO:0005634nucleus IDA18339854
GO:0005657replication fork IDA18363965

Find genes that share ontologies with UBE2B           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for UBE2B About   (see all 7)  
See pathways by source

SuperPathContained pathways About
1Class I MHC mediated antigen processing and presentation
Class I MHC mediated antigen processing and presentation0.84
Adaptive Immune System0.41
Antigen processing- Ubiquitination and Proteasome degradation0.84
Ubiquitin mediated proteolysis0.35
2Cell Cycle / Checkpoint Control
Cell Cycle / Checkpoint Control0.32
DNA Damage0.32
3CDK-mediated phosphorylation and removal of Cdc6
Proteasome Degradation0.57
4TGF-Beta Pathway
SOCS Pathway0.40
5Ubiquitin-Proteasome Dependent Proteolysis
Ubiquitin-Proteasome Dependent Proteolysis


Find genes that share SuperPaths with UBE2B           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBE2B
    Ubiquitin-Proteasome Dependent Proteolysis
Remodeling of Adherens Junctions
SOCS Pathway

3 Cell Signaling Technology (CST) Pathways for UBE2B
    Cell Cycle / Checkpoint Control
DNA Damage
Protein Stability

1 BioSystems Pathway for UBE2B
    Proteasome Degradation


1 Reactome Pathway for UBE2B
    Antigen processing: Ubiquitination & Proteasome degradation


1 Kegg Pathway  (Kegg details for UBE2B):
    Ubiquitin mediated proteolysis

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146
Pathway: Protein modification; protein ubiquitination

    Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2B: 

          Ubiquitination (Ubiquitylation) Pathway in human mouse rat
          Epigenetic Chromatin Modification Enzymes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for UBE2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for UBE2B (P631462, 3 ENSP000002653394) via UniProtKB, MINT, STRING, and/or I2D (see all 220)
InteractantInteraction Details
GeneCardExternal ID(s)
MED31Q9Y3C72, 3MINT-63985 I2D: score=4 
UNC119Q134322, 3MINT-63982 I2D: score=4 
CRMP1Q141942, 3MINT-63983 I2D: score=3 
UBCP0CG482, 3, ENSP000003448184MINT-50303 I2D: score=1 STRING: ENSP00000344818
UBR1Q8IWV72, 3, ENSP000002906504MINT-63984 I2D: score=4 STRING: ENSP00000290650
About this table

Gene Ontology (GO): Selected biological process terms (see all 31):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000209protein polyubiquitination IMP18339854
GO:0001666response to hypoxia IEA--
GO:0001701in utero embryonic development IEA--
GO:0006281DNA repair IGI1717990
GO:0006301postreplication repair NAS1559696

Find genes that share ontologies with UBE2B           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for UBE2B

4 HMDB Compounds for UBE2B    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine monophosphate5'-AMP (see all 28)61-19-8--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

1 Novoseek inferred chemical compound relationship for UBE2B gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
halothane 33.7 3 8415876 (2), 7716787 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for UBE2B gene: 
NM_003337.2  

Unigene Cluster for UBE2B:

Ubiquitin-conjugating enzyme E2B
Hs.612096  [show with all ESTs]
Unigene Representative Sequence: NM_003337
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000265339(uc003kzh.3) ENST00000510021 ENST00000511807 ENST00000506787
ENST00000507277 ENST00000504431 ENST00000499038 ENST00000503080
miRNA
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Block miRNA regulation of human, mouse, rat UBE2B using miScript Target Protectors
Selected qRT-PCR Assays for microRNAs that regulate UBE2B (see all 87):
hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-519a hsa-miR-3161 hsa-miR-890 hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmidUBE2B 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for UBE2B
Predesigned siRNA for gene silencing in human, mouse, rat UBE2B
Clone
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OriGene clones in human, mouse for UBE2B (see all 6)
OriGene ORF clones in mouse, rat for UBE2B
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: UBE2B (NM_003337)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBE2B
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2B
Addgene plasmids for UBE2B 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for UBE2B
OriGene qSTAR qPCR primer pairs in human, mouse for UBE2B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2B
  QuantiTect SYBR Green Assays in human, mouse, rat UBE2B
  QuantiFast Probe-based Assays in human, mouse, rat UBE2B

Additional mRNA sequence: 

AK057639.1 AK312012.1 BC005979.1 BC008404.1 BC008470.1 BT007071.1 CR407634.1 M74525.1 
X53251.1 

20 DOTS entries:

DT.319282  DT.100808685  DT.100808677  DT.97846777  DT.70101729  DT.92439916  DT.100044489  DT.40121603 
DT.92439905  DT.40133261  DT.100699719  DT.100768866  DT.100808676  DT.100808679  DT.100808682  DT.86852750 
DT.92439919  DT.95104579  DT.95352653  DT.40133263 

Selected AceView cDNA sequences (see all 314):

BM976620 BQ014418 BU679339 CA427693 BE908018 CA427213 BQ001089 CA428093 
BI755252 CR604876 BM552908 BE464232 BQ773956 BQ014034 AW195838 BM680751 
AA126538 CR616089 AA490994 BF593427 BQ422988 CA432625 AA669428 AI453401 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2B    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1:                    -                       -                           
SP2:                    -     -                 -                           
SP3:                    -     -     -           -                           
SP4:                          -     -     -                                 


ECgene alternative splicing isoforms for UBE2B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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UBE2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTCCGCAGCT
UBE2B Expression
About this image


UBE2B expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 4) fully expand
 
 Heart (Cardiovascular System)
         Atrioventricular Canal Cells Atrioventricular Canal
 
 Testis (Reproductive System)
         Spermatid Seminiferous Tubules
 
 Gonad
         Spermatid Seminiferous Tubules
 
 Blood (Hematopoietic System)
         Granulocytes Peripheral Blood
UBE2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

UBE2B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.612096
    Pathway & Disease-focused RT2 Profiler PCR Arrays including UBE2B: 
          Ubiquitination (Ubiquitylation) Pathway in human mouse rat
          Epigenetic Chromatin Modification Enzymes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for UBE2B
OriGene qSTAR qPCR primer pairs in human, mouse for UBE2B
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBE2B
QuantiTect SYBR Green Assays in human, mouse, rat UBE2B
QuantiFast Probe-based Assays in human, mouse, rat UBE2B
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2B

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2B gene from Selected species (see all 26)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ube2b1 , 5 ubiquitin-conjugating enzyme E2B, RAD6 homology (S. more5
ubiquitin-conjugating enzyme E2B1
95.61(n)1
100(a)1
  11 (31.82 cM)5
222101  NM_009458.41  NP_033484.31 
 519854975 
chicken
(Gallus gallus)
Aves LOC1008576781 ubiquitin-conjugating enzyme E2 B-like 87.39(n)
95.27(a)
  100857678  XM_004945000.1  XP_004945057.1 
lizard
(Anolis carolinensis)
Reptilia UBE2B6
ubiquitin-conjugating enzyme E2B
99(a)
1 ↔ 1
2(130931985-130945163)
African clawed frog
(Xenopus laevis)
Amphibia Xl.174662 Xenopus laevis transcribed sequence with strong similarity more 84.98(n)    BX854470.1 
zebrafish
(Danio rerio)
Actinopterygii wufc79h102 wufc79h10 80.92(n)   325470  BC044416.1 
fruit fly
(Drosophila melanogaster)
Insecta UbcD63 DNA repair ubiquitin conjugating enzyme 86(a)   82E4   --
worm
(Caenorhabditis elegans)
Secernentea ubc-13 ubiquitin conjugating-protein 84(a)   IV(4103222-4105426)   --
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD61 RAD6 63.6(n)
69.08(a)
  852822   NP_011457.1 
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.75592 Vitis vinifera transcribed sequence with strong similarity more 76.88(n)    CB970775.1 
barley
(Hordeum vulgare)
Liliopsida Hv.6792 Transcribed sequence with strong similarity to protein more 71.36(n)    BE213901.1 


ENSEMBL Gene Tree for UBE2B (if available)
TreeFam Gene Tree for UBE2B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for UBE2B gene
UBE2S2  UBE2A2  UBE2U2  
Selected SIMAP similar genes for UBE2B using alignment to 4 protein entries:     UBE2B_HUMAN (see all proteins) (see all similar genes):
UBE2A    RHBG    HR6A    NLN    MST132    TUBA1C
RQCD1    RBP7    UBE2D3    UBE2D4    UBE2D2    UBE2D1
UBE2M    UBE2N    UBE2E2    UBE2E3    UBE2H    UBE2G2

Find genes that share paralogs with UBE2B           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for UBE2B (see all 464)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs351747081,2
C,F--133705019(+) TTCCTT/CACCTC 1 -- us2k15Minor allele frequency- C:0.00NS 190
rs1868348631,2
--133705027(+) CTCTAC/TTGCCT 1 -- us2k10--------
rs1164942821,2
C,F--133705056(+) ACTTCG/ATTGGT 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1450520271,2
--133705160(+) GCCCAC/TAGTTC 1 -- us2k10--------
rs7637431,2
H--133705274(+) TACAAG/CGGTTT 1 -- us2k17Minor allele frequency- C:0.00EA NA NS 470
rs38342751,2
C,F--133705297(+) CGGGA-/TTTTTT 1 -- us2k16Minor allele frequency- T:0.22NS NA 186
rs1476294011,2
C--133705416(+) GCCACA/CATGCC 1 -- us2k10--------
rs1915533121,2
C--133705424(+) GCCTGA/GCTAAT 1 -- us2k10--------
rs1408884691,2
--133705473(+) GGCTGA/GTCTTC 1 -- us2k10--------
rs1501782601,2
--133705587(+) GTAACA/CCTACC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for UBE2B (133706870 - 133727799 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for UBE2B:    About this table    
Variant IDTypeSubtypePubMed ID
esv8462CNV Gain19470904

Human Gene Mutation Database (HGMD): UBE2B
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing UBE2B
DNA2.0 Custom Variant and Variant Library Synthesis for UBE2B

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 179095    OMIM disorders: --

1 disease for UBE2B:    
About MalaCards
male infertility


Find genes that share disorders with UBE2B           About GenesLikeMe

4 Novoseek inferred disease relationships for UBE2B gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis halothane 81.3 3 8415876 (2), 7716787 (1)
mimicry 41.5 2 7716787 (1), 8415876 (1)
papilloma 33.7 5 10999461 (2), 10738224 (1)
tumors 0 1 10999461 (1)

Genetic Association Database (GAD): UBE2B
Human Genome Epidemiology (HuGE) Navigator: UBE2B (3 documents)

Export disorders for UBE2B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for UBE2B gene, integrated from 10 sources (see all 88):
(articles sorted by number of sources associating them with UBE2B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. (PubMed id 1559696)1, 3, 9 Koken M.H....Hoeijmakers J.H. (Genomics 1992)
  2. The human RAD18 gene product interacts with HHR6A and HHR6B. (PubMed id 10908344)1, 2, 9 Xin H.... Wang Z. (Nucleic Acids Res. 2000)
  3. Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent. (PubMed id 20378615)1, 4 Aston K.I....Carrell D.T. (Hum. Reprod. 2010)
  4. Novel variants in UBE2B gene and idiopathic male infertility. (PubMed id 18497339)1, 4 Suryavathi V....Thangaraj K. (J. Androl. 2008)
  5. Novel UBE2B-associated polymorphisms in an azoospermic/oligozoospermic population. (PubMed id 18385908)1, 4 Huang I....Carrell D.T. (Asian J. Androl. 2008)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. (PubMed id 11885984)1, 2 Miura T.... Senn H. (J. Biomol. NMR 2002)
  8. Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. (PubMed id 1717990)1, 2 Koken M.H.M.... Hoeijmakers J.H.J. (Proc. Natl. Acad. Sci. U.S.A. 1991)
  9. Mammalian mRNAs encoding protein closely related to ubiquitin- conjugating enzyme encoded by yeast DNA repair gene RAD6. (PubMed id 1883845)1, 2 Woffendin C.... Plagemann P.G. (Biochim. Biophys. Acta 1991)
  10. The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6. (PubMed id 2158443)1, 2 Schneider R.... Schweiger M. (EMBO J. 1990)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 7320 HGNC: 12473 AceView: UBE2B Ensembl:ENSG00000119048 euGenes: HUgn7320
ECgene: UBE2B Kegg: 7320 H-InvDB: UBE2B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for UBE2B Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for UBE2B Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/ube2b/

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for UBE2B gene:
Search GeneIP for patents involving UBE2B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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