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Aliases for UBE2B Gene

Aliases for UBE2B Gene

  • Ubiquitin Conjugating Enzyme E2 B 2 3
  • Ubiquitin-Conjugating Enzyme E2B (RAD6 Homolog) 2 3
  • Ubiquitin-Conjugating Enzyme E2-17 KDa 3 4
  • E2 Ubiquitin-Conjugating Enzyme B 3 4
  • Ubiquitin Conjugating Enzyme E2B 3 5
  • Ubiquitin Carrier Protein B 3 4
  • Ubiquitin-Protein Ligase B 3 4
  • RAD6 Homolog B 3 4
  • HHR6B 3 4
  • RAD6B 3 4
  • HR6B 3 4
  • Ubiquitin-Conjugating Enzyme E2B 2
  • EC 6.3.2.19 63
  • EC 2.3.2.23 4
  • E2 Protein 3
  • E2-17kDa 3
  • UBC2 3

External Ids for UBE2B Gene

Previous GeneCards Identifiers for UBE2B Gene

  • GC05P133355
  • GC05P134221
  • GC05P133737
  • GC05P133783
  • GC05P133734
  • GC05P133706
  • GC05P128891

Summaries for UBE2B Gene

Entrez Gene Summary for UBE2B Gene

  • The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBE2B Gene

UBE2B (Ubiquitin Conjugating Enzyme E2 B) is a Protein Coding gene. Diseases associated with UBE2B include aggressive systemic mastocytosis and papilloma. Among its related pathways are Immune System and DNA Double-Strand Break Repair. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is UBE2A.

UniProtKB/Swiss-Prot for UBE2B Gene

  • Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at Lys-120 to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes Lys-11-, as well as Lys-48- and Lys-63-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. May be involved in neurite outgrowth.

Gene Wiki entry for UBE2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2B Gene

Genomics for UBE2B Gene

Regulatory Elements for UBE2B Gene

Promoters for UBE2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2B on UCSC Golden Path with GeneCards custom track

Genomic Location for UBE2B Gene

Chromosome:
5
Start:
134,371,176 bp from pter
End:
134,392,108 bp from pter
Size:
20,933 bases
Orientation:
Plus strand

Genomic View for UBE2B Gene

Genes around UBE2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2B Gene

Proteins for UBE2B Gene

  • Protein details for UBE2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63146-UBE2B_HUMAN
    Recommended name:
    Ubiquitin-conjugating enzyme E2 B
    Protein Accession:
    P63146
    Secondary Accessions:
    • B2R503
    • D3DQA2
    • P23567
    • Q4PJ15
    • Q9D0J6

    Protein attributes for UBE2B Gene

    Size:
    152 amino acids
    Molecular mass:
    17312 Da
    Quaternary structure:
    • Interacts with RAD18, UBR2 and WAC.

    Three dimensional structures from OCA and Proteopedia for UBE2B Gene

neXtProt entry for UBE2B Gene

Proteomics data for UBE2B Gene at MOPED

Post-translational modifications for UBE2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBE2B Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2B (UBE2B)

Domains & Families for UBE2B Gene

Gene Families for UBE2B Gene

Protein Domains for UBE2B Gene

Suggested Antigen Peptide Sequences for UBE2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P63146

UniProtKB/Swiss-Prot:

UBE2B_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2B: view

Function for UBE2B Gene

Molecular function for UBE2B Gene

GENATLAS Biochemistry:
ubiquitin conjugating enzyme E2B,involved in post replication repair,containing a CGG repeat in 5utr
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
UniProtKB/Swiss-Prot Function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at Lys-120 to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes Lys-11-, as well as Lys-48- and Lys-63-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. May be involved in neurite outgrowth.

Enzyme Numbers (IUBMB) for UBE2B Gene

Gene Ontology (GO) - Molecular Function for UBE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with UBE2B: view
genes like me logo Genes that share phenotypes with UBE2B: view

Animal Models for UBE2B Gene

MGI Knock Outs for UBE2B:

Animal Model Products

miRNA for UBE2B Gene

miRTarBase miRNAs that target UBE2B

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2B Gene

Localization for UBE2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2B Gene

Cell membrane. Nucleus. Note=In peripheral neurons, expressed both at the plasma membrane and in nuclei. {ECO:0000250 UniProtKB:P63149}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2B Gene COMPARTMENTS Subcellular localization image for UBE2B gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 2
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for UBE2B Gene

Pathways & Interactions for UBE2B Gene

genes like me logo Genes that share pathways with UBE2B: view

UniProtKB/Swiss-Prot P63146-UBE2B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IMP 18339854
GO:0001701 in utero embryonic development IEA --
GO:0006281 DNA repair IGI,TAS 1717990
GO:0006974 cellular response to DNA damage stimulus IDA 14981545
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with UBE2B: view

No data available for SIGNOR curated interactions for UBE2B Gene

Drugs & Compounds for UBE2B Gene

(4) Drugs for UBE2B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2B Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with UBE2B: view

Transcripts for UBE2B Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2B Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - - -

Relevant External Links for UBE2B Gene

GeneLoc Exon Structure for
UBE2B
ECgene alternative splicing isoforms for
UBE2B

Expression for UBE2B Gene

mRNA expression in normal human tissues for UBE2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2B Gene

This gene is overexpressed in Urine (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2B Gene



SOURCE GeneReport for Unigene cluster for UBE2B Gene Hs.612096

genes like me logo Genes that share expression patterns with UBE2B: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for UBE2B Gene

Orthologs for UBE2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2B 35
  • 97.37 (n)
  • 100 (a)
UBE2B 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2B 35
  • 98.46 (n)
  • 100 (a)
UBE2B 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2b 35
  • 95.61 (n)
  • 100 (a)
Ube2b 16
Ube2b 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2B 35
  • 100 (n)
  • 100 (a)
UBE2B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2b 35
  • 92.32 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2B 36
  • 100 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2B 36
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857678 35
  • 87.39 (n)
  • 95.27 (a)
UBE2B 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2B 36
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11129 35
ube2b 35
  • 85.75 (n)
  • 98.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.17466 35
zebrafish
(Danio rerio)
Actinopterygii ube2b 35
  • 76.54 (n)
  • 95.39 (a)
wufc79h10 35
ube2b 36
  • 95 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9365 35
fruit fly
(Drosophila melanogaster)
Insecta UbcD6 37
  • 86 (a)
UbcD6 36
  • 86 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-1 37
  • 84 (a)
ubc-1 36
  • 67 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR156C 35
  • 57.24 (n)
  • 69.08 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C05632g 35
  • 64.02 (n)
  • 70.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD6 35
  • 63.6 (n)
  • 69.08 (a)
RAD6 36
  • 61 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7559 35
barley
(Hordeum vulgare)
Liliopsida Hv.679 35
corn
(Zea mays)
Liliopsida Zm.3859 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6140 35
bread mold
(Neurospora crassa)
Ascomycetes NCU09731 35
  • 61.15 (n)
  • 68.21 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp6 35
  • 63.31 (n)
  • 71.81 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6239 36
  • 80 (a)
OneToMany
Species with no ortholog for UBE2B:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBE2B Gene

ENSEMBL:
Gene Tree for UBE2B (if available)
TreeFam:
Gene Tree for UBE2B (if available)

Paralogs for UBE2B Gene

Paralogs for UBE2B Gene

genes like me logo Genes that share paralogs with UBE2B: view

Variants for UBE2B Gene

Sequence variations from dbSNP and Humsavar for UBE2B Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs167870 -- 134,389,794(-) cgagg(C/T)gggca intron-variant
rs328037 -- 134,390,211(-) AAAGA(A/G)AAGAA intron-variant
rs328038 -- 134,387,103(-) gcatg(C/T)gtgta intron-variant
rs328044 -- 134,373,483(-) tattt(A/T)aaaaa intron-variant
rs1803727 -- 134,380,789(+) TTATC(C/T)AAAAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for UBE2B Gene

Variant ID Type Subtype PubMed ID
esv8462 CNV Gain 19470904

Variation tolerance for UBE2B Gene

Residual Variation Intolerance Score: 40.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.16% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2B Gene

HapMap Linkage Disequilibrium report
UBE2B
Human Gene Mutation Database (HGMD)
UBE2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2B Gene

Disorders for UBE2B Gene

MalaCards: The human disease database

(2) MalaCards diseases for UBE2B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
aggressive systemic mastocytosis
  • asm
papilloma
  • papillomatosis
- elite association - COSMIC cancer census association via MalaCards
Search UBE2B in MalaCards View complete list of genes associated with diseases

Relevant External Links for UBE2B

Genetic Association Database (GAD)
UBE2B
Human Genome Epidemiology (HuGE) Navigator
UBE2B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2B
genes like me logo Genes that share disorders with UBE2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBE2B Gene

Publications for UBE2B Gene

  1. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. (PMID: 1559696) Koken M.H. … Hoeijmakers J.H. (Genomics 1992) 2 3 23 67
  2. Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. (PMID: 18363965) Tsuji Y. … Tateishi S. (Genes Cells 2008) 3 23
  3. Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. (PMID: 17050667) Shekhar M.P. … Gerard B. (Mol. Cancer Res. 2006) 3 23
  4. RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. (PMID: 14981545) Lyakhovich A. … Shekhar M.P. (Oncogene 2004) 3 23
  5. The human RAD18 gene product interacts with HHR6A and HHR6B. (PMID: 10908344) Xin H. … Wang Z. (Nucleic Acids Res. 2000) 3 23

Products for UBE2B Gene

Sources for UBE2B Gene

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