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UBE2B Gene

protein-coding GIFtS: 68

GC05P133734

ubiquitin-conjugating enzyme E2B (RAD6 homolog)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
E2-17kDa ^²
EC 6.3.2.19 ^³
HHR6B ^¹, ²
HR6B ^², ³
RAD6B ^², ³, ⁵
UBC2 ^¹, ²
hHR6B ^³

Descriptions
E2 protein ^²
E2-17 kDa ^³
Ubiquitin carrier protein B ^², ³
Ubiquitin-protein ligase B ^², ³
ubiquitin-conjugating enzyme E2B ^²
ubiquitin-conjugating enzyme E2B (RAD6 homolog) ^²

External Ids
HGNC: 12473¹
Entrez Gene: 7320²
UniProtKB: P63146³
Ensembl: ENSG00000119048⁷

Search outside databases for aliases for UBE2B gene

Previous GC identifers: GC05P133355 GC05P134221 GC05P133737 GC05P133783

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBE2B:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting

abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes

of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and

ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating

enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein

sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this

enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Required for

postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the

UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on

'Lys-164'. May be involved in neurite outgrowth

Gene Wiki entry for UBE2B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBE2B gene

Entrez Gene cytogenetic band: 5q23-q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31.1

UBE2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P133734: (about GC identifiers)

Start:	133,734,769 bp from pter
End:	133,755,698 bp from pter
Size:	20,930 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000005.8 NT_034772.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146 (See protein sequence)

Recommended Name: Ubiquitin-conjugating enzyme E2 B

Size: 152 amino acids; 17312 Da

Subunit: Interacts with RAD18 and UBR2

Subcellular location: Cell membrane (By similarity). Nucleus (By similarity). Note=In peripheral

neurons, expressed both at the plasma membrane and in nuclei (By similarity)

PDB structure from and Proteopedia :

1JAS (3D)

1NXA (3D)

Secondary accessions: P23567 Q4PJ15 Q9D0J6

REFSEQ proteins: NP_003328.1

ENSEMBL proteins:

ENSP00000265339

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBE2B Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBE2B
	Recombinant Proteins from Abcam (Ube2B)
	Human Recombinant Proteins from Abnova (UBE2B)

OriGene Purified Recombinant Human Protein: UBE2B

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000785	chromatin	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005886	plasma membrane	IEA	--

About this table

Antibodies for UBE2B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for UBE2B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ube2B), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBE2B)
	Novus Biologicals Antibodies for UBE2B

Assays for UBE2B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Enzo Life Sciences assays for UBE2B

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P63146

ProtoNet protein and cluster: P63146

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146

Similarity: Belongs to the ubiquitin-conjugating enzyme family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003337

Applied Biosystems Silencer® siRNAs for UBE2B

Sigma-Aldrich siRNA and siRNA Panels for UBE2B

Sigma-Aldrich shRNA Panels and shRNA for UBE2B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBE2B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003337
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003337
untagged cDNA clones in CMV expression vector (see all 2): BC001694

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003337

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146

Function: Catalyzes the covalent attachment of ubiquitin to other proteins. Required for

postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the

UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on

'Lys-164'. May be involved in neurite outgrowth

Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein

N-ubiquityllysine

Enzyme Number (IUBMB): EC 6.3.2.19

Genatlas biochemistry entry for UBE2B:

ubiquitin conjugating enzyme E2B,involved in post replication repair,containing a CGG repeat in

5'utr

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ube2b):

endocrine/exocrine gland

growth/size

lethality-prenatal/perinatal

reproductive system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004842	ubiquitin-protein ligase activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0016874	ligase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for UBE2B (Your Favorite Gene powered by Ingenuity)

Hypoxia Signaling in the Cardiovascular System
Protein Ubiquitination Pathway

GeneDecks UBE2B for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146

Pathway: Protein modification; protein ubiquitination

Gene Network Central^TM Interacting Genes and Proteins Network for UBE2B

5/16 Interacting proteins for UBE2B (ENSP00000265339³ P63146²) via UniProtKB, MINT, and/or STRING (see all 16 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBC	P62988²	STRING (score=.929) MINT-50303
CRMP1	Q14194²	MINT-63983
MED31	Q9Y3C7²	MINT-63985
RPS27A	P62988²	MINT-50303
RPS27AP11	P62988²	MINT-50303

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006301	postreplication repair	TAS	1559696
GO:0006511	ubiquitin-dependent protein catabolic process	TAS	1559696
GO:0006974	response to DNA damage stimulus	IEA	--
GO:0007288	sperm axoneme assembly	IEA	--
GO:0043687	post-translational protein modification	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBE2B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBE2B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBE2B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003337

Sigma-Aldrich siRNA and siRNA Panels for UBE2B

Sigma-Aldrich shRNA Panels and shRNA for UBE2B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003337

REFSEQ mRNAs for UBE2B gene:

NM_003337.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003337

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003337
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003337
                                 untagged cDNA clones in CMV expression vector (see all 2): BC001694

Additional cDNA sequence:

AK057639.1 AK312012.1 BC005979.1 BC008404.1 BC008470.1 BT007071.1 CR407634.1 CR604876.1

CR616089.1 CR625304.1 M74525.1 X53251.1

20 DOTS entries:

DT.319282 DT.100808685 DT.100808677 DT.40121603 DT.92439916 DT.97846777 DT.70101729 DT.100044489

DT.92439905 DT.40133261 DT.100699719 DT.100768866 DT.100808676 DT.95104579 DT.100808679 DT.100808682

DT.40133263 DT.86852750 DT.92439919 DT.95352653

24/314 AceView cDNA sequences (see all 314 ):

BU687077 AA490994 BM993110 BI755252 AI434206 BQ422988 BE904209 AA552980

BM718879 CB243683 NM_003337 CF127499 BQ018092 BM976620 BU616515 CA427693

BM552908 BM680751 CA432625 AA126538 BU679339 BU686894 BQ001089 AA669428

highest scoring ESTs for UBE2B:

AI985481 AW002331 M74525 AA010721 AA011168 AA018371 AA019149 AA046249 AA046368 AA053973

Unigene Clusters for UBE2B:

Ubiquitin-conjugating enzyme E2B (RAD6 homolog)

Hs.615284 , Hs.644421 [show with all ESTs]

Unigene Representative Sequences: BC001694, NM_003337

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2B

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e
SP1:							-								-
SP2:							-		-						-
SP3:							-		-		-				-
SP4:									-		-		-

About this scheme

ECgene alternative splicing isoforms for UBE2B

1 Ensembl transcript including schematic representation:

ENST00000265339

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBE2B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBE2B

¹ / ² / ³

15 probe-sets matching UBE2B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1231_at²^{, 3}	U95-A	1	1.00	1.00	0.73	0.58	M74525	1.00	1.00	1.00	1
74932_at²^{, 3}	U95-D	1	1.00	1.00	0.95	1.39	AW002331	1.00	1.00	1.00	1
89867_at²^{, 3}	U95-D	1	0.81	1.00	0.94	1.29	AI985481	1.00	1.00	1.00	1
89960_at²^{, 3}	U95-D	1	0.50	1.00	0.90	1.34	AA897541	0.80	1.00	0.91	1
86213_at*²^{, 3}	U95-D	1	--	--	0.40	0.42	AI266585	0.40	1.00	0.76	1
211763_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC005979	0.80	1.00	0.91	1
202333_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA877765	0.80	1.00	0.91	1
202335_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003337	0.60	1.00	0.82	1
202334_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI768723	0.80	1.00	0.91	1
224118_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC001694	0.60	1.00	0.82	1
211763_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202333_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202335_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202334_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224118_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAAGCTGTT

SOURCE GeneReport for Unigene clusters: Hs.615284 Hs.644421
Expression variation in blood from EXPOLDB for UBE2B

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBE2B gene from 5/22 species (see all 22 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBE2B¹	--	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	98.46(n) 100(a)	474683 XM_845564.1 XP_850657.1
chimpanzee (Pan troglodytes)	UBE2B¹	--	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	100(n) 100(a)	462065 XM_517935.2 XP_517935.2
cow (Bos taurus)	UBE2B¹	--	ubiquitin-conjugating enzyme E2B (RAD6 homolog)	97.37(n) 100(a)	512207 NM_001037459.1 NP_001032536.1
rat (Rattus norvegicus)	Ube2b¹	--	ubiquitin-conjugating enzyme E2B, RAD6 homology (S. more	92.32(n) 100(a)	81816 NM_031138.1 NP_112400.1
mouse (Mus musculus)	Ube2b^{1, 5}	11⁵	ubiquitin-conjugating enzyme E2B, RAD6 homology (S. more^{1, 5}	95.18(n)¹ 99.34(a)¹	22210¹ NM_009458.3¹ NP_033484.2¹ AK010432⁵ AK011363⁵ (see all 21)

About this table Species with no ortholog for UBE2B

ENSEMBL Gene Tree for UBE2B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBE2B gene

UBE2C² UBE2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/180 NCBI SNPs in UBE2B are shown (see all 180 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 98)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1379247^1,2	A,C,F,H,O	133734511(-)	`ATAGAG/AACAAC`	1	--	ng5¹		14	MN NA EU EA WA NS	1066
	rs3777373^1,2	C,F,H	133755202(+)	`GGATTA/GCAGTA`	1	--	ut3¹ ese³		13	EA NA EU WA NS	2234
	rs2290619^1,2	C,F,H	133733911(-)	`TCCCAA/CAGACC`	1	--	ng5¹		14	EA NA EU WA NS	2422
	rs17167484^1,2	C,F,H	133734893(+)	`TTGTCT/GATTAC`	1	--	ut5¹ ese³		11	NA EU EA NS	586
--	rs3834275^1,2	C,F	133733202(+)	`ttttt-/Tgaggc`	1	--	ng5¹		5	NS	184
--	rs11538104^1,2	C,F	133754951(-)	`AGAAGA/CAGCAA`	1	--	ut3¹ ese³		5	NS	184
	rs10039980^1,2	F,H	133734450(+)	`TTGGTC/GCCGGT`	1	--	ng5¹		4	EU EA WA	418
	rs763743^1,2	H	133733173(+)	`TACAAG/CGGTTT`	1	--	ng5¹		7	EA NA EU WA	476
	rs35846335^1,2	F	133733526(+)	`GGTTAG/AGACTG`	1	--	ng5¹		5	NS	190
--	rs34553375^1,2	F	133735091(+)	`GGCGGC/TGGCGA`	1	--	ut5¹		5	NS	152

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HapMap Linkage Disequilibrium images for UBE2B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 179095

4 Novoseek disease relationships for UBE2B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis halothane	81.46	3	8415876 (2), 7716787 (1)
mimicry	42.64	2	7716787 (1), 8415876 (1)
papilloma	34.70	5	10999461 (2), 10738224 (1)
tumors	0.00	1	10999461 (1)

About this table

Human Gene Mutation Database: UBE2B
Human Genome Epidemiology Navigator: UBE2B (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/49 PubMed articles for UBE2B gene (see all 49 ):

Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. (PubMed id 1559696)^{1, 2, 3} Koken M.H....Hoeijmakers J.H. (1992)
The human RAD18 gene product interacts with HHR6A and HHR6B. (PubMed id 10908344)^{1, 3, 4} Xin H....Wang Z. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. (PubMed id 11885984)^{3, 4} Miura T.... Senn H. (2002)
Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. (PubMed id 1717990)^{3, 4} Koken M.H.M.... Hoeijmakers J.H.J. (1991)
Mammalian mRNAs encoding protein closely related to ubiquitin- conjugating enzyme encoded by yeast DNA repair gene RAD6. (PubMed id 1883845)^{3, 4} Woffendin C.... Plagemann P.G. (1991)
The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6. (PubMed id 2158443)^{3, 4} Schneider R.... Schweiger M. (1990)
Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. (PubMed id 17050667)^{1, 3} Shekhar M.P....Gerard B. (2006)
RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. (PubMed id 14981545)^{1, 3} Lyakhovich A. and Shekhar M.P. (2004)
Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. (PubMed id 18363965)^{1, 3} Tsuji Y....Tateishi S. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7320	HGNC: 12473	AceView: UBE2B	Ensembl:ENSG00000119048	euGenes: HUgn7320
ECgene: UBE2B	H-InvDB: UBE2B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for UBE2B	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/ube2b/

Licensable Technologies for UBE2B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBE2B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBE2B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBE2B		Antibodies for UBE2B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBE2B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Recombinant Proteins (Ube2B)
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Antibodies for UBE2B

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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UBE2B Gene at Home site.
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UBE2B Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for UBE2B

Summaries
for UBE2B

Genomic Location
for UBE2B

Proteins
for UBE2B

Protein Domains/
Families
for UBE2B

Gene Function
for UBE2B

Pathways & Interactions
for UBE2B

Drugs & Compounds
for UBE2B

Transcripts
for UBE2B

Expression
for UBE2B

Orthologs
for UBE2B

Paralogs
for UBE2B

SNPs/Variants
for UBE2B

Disorders & Mutations
for UBE2B

Medical News
for UBE2B

Publications
for UBE2B

Search for UBE2B

Genome Databases showing UBE2B

Other Databases showing UBE2B

Specialized Databases showing UBE2B

Licensable Technologies
for UBE2B

Services
for UBE2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBE2B Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor UBE2B

Summariesfor UBE2B

Genomic Locationfor UBE2B

Proteinsfor UBE2B

Protein Domains/Familiesfor UBE2B

Gene Functionfor UBE2B

Pathways & Interactionsfor UBE2B

Drugs & Compoundsfor UBE2B

Transcriptsfor UBE2B

Expression for UBE2B

Orthologsfor UBE2B

Paralogsfor UBE2B

SNPs/Variantsfor UBE2B

Disorders & Mutationsfor UBE2B

Medical Newsfor UBE2B

Publicationsfor UBE2B

Search for UBE2B

Genome Databases showing UBE2B

Other Databases showing UBE2B

Specialized Databases showing UBE2B

Licensable Technologiesfor UBE2B

Servicesfor UBE2B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBE2B

Summaries
for UBE2B

Genomic Location
for UBE2B

Proteins
for UBE2B

Protein Domains/
Families
for UBE2B

Gene Function
for UBE2B

Pathways & Interactions
for UBE2B

Drugs & Compounds
for UBE2B

Transcripts
for UBE2B

Expression
for UBE2B

Orthologs
for UBE2B

Paralogs
for UBE2B

SNPs/Variants
for UBE2B

Disorders & Mutations
for UBE2B

Medical News
for UBE2B

Publications
for UBE2B

Licensable Technologies
for UBE2B

Services
for UBE2B