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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBE2B Gene

protein-coding   GIFtS: 70
GCID: GC05P133706

ubiquitin-conjugating enzyme E2B

(Previous name: ubiquitin-conjugating enzyme E2B (RAD6 homolog) )
 Explore 12 diseases affiliated with
UBE2B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UBE2B    

Aliases
for UBE2B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin-Conjugating Enzyme E2B1 2     HR6B2 3
RAD6B1 2 3 5     RAD6 Homolog B2 3
HHR6B1 2     EC 6.3.2.193 8
UBC21 2     E2-17kDa2
Ubiquitin-Conjugating Enzyme E2B (RAD6 Homolog)1 2     E2 Protein2
Ubiquitin Carrier Protein B2 3     Ubiquitin-Conjugating Enzyme E2 B2
Ubiquitin-Conjugating Enzyme E2-17 KDa2 3     HHR6B1 2
Ubiquitin-Protein Ligase B2 3     

External Ids:    HGNC: 124731   Entrez Gene: 73202   Ensembl: ENSG000001190487   OMIM: 1790955   UniProtKB: P631463   

Export aliases for UBE2B gene to outside databases

Previous GC identifers: GC05P133355 GC05P134221 GC05P133737 GC05P133783 GC05P133734 GC05P128891


Summaries
for UBE2B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UBE2B:
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived
proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or
E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the
E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein
sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly
conserved in eukaryotic evolution. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association
with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the
monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic
transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for
H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked
polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form
the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be
involved in neurite outgrowth

Gene Wiki entry for UBE2B


Genomic Views
for UBE2B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_034772.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBE2B gene promoter:
         COUP-TF1   GR   Sp1   COUP   HNF-4alpha2   HNF-4alpha1   COUP-TF   ARP-1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBE2B promoter sequence
   Search SABiosciences Chromatin IP Primers for UBE2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBE2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.1   Ensembl cytogenetic band:  5q31.1   HGNC cytogenetic band: 5q31.1

UBE2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBE2B gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P133706:  view genomic region     (about GC identifiers)

Start:
 133,706,870 bp from pter      End:
 133,727,799 bp from pter
Size:
 20,930 bases      Orientation:
 plus strand

Proteins
for UBE2B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146 (See protein sequence)
Recommended Name: Ubiquitin-conjugating enzyme E2 B  
Size: 152 amino acids; 17312 Da
Subunit: Interacts with RAD18, UBR2 and WAC
Subcellular location: Cell membrane (By similarity). Nucleus (By similarity). Note=In peripheral neurons, expressed
both at the plasma membrane and in nuclei (By similarity)
5 PDB 3D structures from and Proteopedia for UBE2B:
1JAS (3D)        1NXA (3D)        2Y4W (3D)        2YB6 (3D)        2YBF (3D)    
Secondary accessions: B2R503 D3DQA2 P23567 Q4PJ15 Q9D0J6

Explore the universe of human proteins at neXtProt for UBE2B: NX_P63146

4/13 DME Specific Peptides for UBE2B (P63146) (see all 13)
 SKMFHPN  CLDILQN  MFHPNVY  AAQLYQEN 

UBE2B Protein expression data from MOPED and PaxDb:    About this image 
Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_003328.1  
ENSEMBL proteins: 
 ENSP00000265339   ENSP00000425237   ENSP00000426364   ENSP00000425137  
Reactome Protein details: P63146
Human Recombinant Protein Products: 
EMD Millipore Purified and/or Recombinant UBE2B Protein
R&D Systems Recombinant & Natural Proteins for UBE2B (HR6B/UBE2B)
Enzo Life Sciences proteins for UBE2B
OriGene Purified Protein: UBE2B
OriGene Protein Over-expression Lysate: UBE2B
OriGene Custom Protein Services for UBE2B 
GenScript Purified and Recombinant Proteins for UBE2B
Novus Biologicals UBE2B Proteins
Novus Biologicals UBE2B Lysates
Browse Sino Biological Recombinant Proteins
ProSpec Recombinant Protein for UBE2B
Uscn Proteins for UBE2B

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000785chromatin ISS--
GO:0000790nuclear chromatin IEA--
GO:0001741XY body IEA--
GO:0005634nucleus IDA18339854
GO:0005657replication fork IDA18363965


UBE2B for ontologies           About GeneDecksing



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ThermoFisher Antibodies for UBE2B

Assay Products for UBE2B: 
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GenScript Custom Assay Services for UBE2B
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Uscn ELISAs and CLIAs for UBE2B

Protein Domains /
Families
for UBE2B gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
UBE2B for domains           About GeneDecksing

3 InterPro domains/families:
 IPR016135 UBQ-conjugating_enzyme/RWD
 IPR023313 UBQ-conjugating_AS
 IPR000608 UBQ-conjugat_E2

Graphical View of Domain Structure for InterPro Entry P63146

ProtoNet protein and cluster: P63146

1 Blocks protein family: IPB000608 Ubiquitin-conjugating enzymes

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146
Similarity: Belongs to the ubiquitin-conjugating enzyme family


Function
for UBE2B gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Function Summary:

     UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146
Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association
with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the
monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic
transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for
H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked
polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form
the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be
involved in neurite outgrowth
Catalytic activity: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine

     Genatlas biochemistry entry for UBE2B:
ubiquitin conjugating enzyme E2B,involved in post replication repair,containing a CGG repeat in 5'utr

Enzyme Number (IUBMB): EC 6.3.2.191 2

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2B
8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2B (see all 87):
hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-519a hsa-miR-3161 hsa-miR-890 hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmid: UBE2B 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2B (see all 7)
OriGene shRNA RFP: UBE2B
OriGene siRNA: UBE2B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2B

Gene Editing
Products:		DNA2.0 Custom Protein Engineering Service for UBE2B

Clone
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OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2B
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBE2B 

Cell Line
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Search LifeMap BioReagents cell lines for UBE2B

In Situ Assay
Products:   
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2B

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004842ubiquitin-protein ligase activity IMP18339854
GO:0005515protein binding IPI12776193
GO:0005524ATP binding IEA--
GO:0016881acid-amino acid ligase activity ----
GO:0031625ubiquitin protein ligase binding IPI10908344


UBE2B for ontologies           About GeneDecksing


2 GenomeRNAi human phenotypes for UBE2B:
 Decreased number of cells in m  Increased circadian period len 

Animal Models:
     Mouse knock-out Ube2btm1Jhjh for UBE2B
     8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Ube2b):
 cellular  endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism 
 immune system  mortality/aging  reproductive system 

UBE2B for phenotypes           About GeneDecksing


Pathways & Interactions
for UBE2B gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Antigen processing: Ubiquitination & Proteasome degradation
Antigen processing: Ubiquitination & Proteasome degradation1.00
Polyubiquitination of substrate0.75
Class I MHC mediated antigen processing & presentation0.83
Ubiquitin mediated proteolysis0.36
2Immune System
Immune System1.00
Adaptive Immune System0.59
3Ubiquitin-Proteasome Dependent Proteolysis
Ubiquitin-Proteasome Dependent Proteolysis1.00
4Remodeling of Adherens Junctions
Remodeling of Adherens Junctions1.00
5Ubiquitinated Orc1 is degraded by the proteasome
Proteasome Degradation0.56

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBE2B
    Ubiquitin-Proteasome Dependent Proteolysis
Remodeling of Adherens Junctions
SOCS Pathway

1 BioSystems Pathway for UBE2B 
    Proteasome Degradation

5        Reactome Pathways for UBE2B
    Antigen processing: Ubiquitination & Proteasome degradation
Polyubiquitination of substrate
Adaptive Immune System
Class I MHC mediated antigen processing & presentation
Immune System


1         Kegg Pathway  (Kegg details for UBE2B):
    Ubiquitin mediated proteolysis

UniProtKB/Swiss-Prot: UBE2B_HUMAN, P63146
Pathway: Protein modification; protein ubiquitination


UBE2B for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBE2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/38 Interacting proteins for UBE2B (P631462, 3 ENSP000002653394) via UniProtKB, MINT, STRING, and/or I2D (see all 38)

InteractantInteraction Details
GeneCardExternal ID(s)
MED31Q9Y3C72, 3MINT-63985 I2D: score=4 
UNC119Q134322, 3MINT-63982 I2D: score=4 
CRMP1Q141942, 3MINT-63983 I2D: score=3 
UBCP0CG482, 3, ENSP000003448184MINT-50303 I2D: score=1 STRING: ENSP00000344818
UBR1Q8IWV72, 3, ENSP000002906504MINT-63984 I2D: score=4 STRING: ENSP00000290650
About this table

Gene Ontology (GO): 5/31 biological process terms (GO ID links to tree view) (see all 31):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000209protein polyubiquitination IMP18339854
GO:0001666response to hypoxia IEA--
GO:0001701in utero embryonic development IEA--
GO:0006281DNA repair IGI1717990
GO:0006301postreplication repair NAS1559696


UBE2B for ontologies           About GeneDecksing



Drugs & Compounds
for UBE2B gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

UBE2B for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for UBE2B

4 HMDB Compounds for UBE2B    About this table
CompoundSynonyms CAS #PubMed Ids
Adenosine monophosphate5'-AMP (see all 28)61-19-8--
Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
1 Novoseek chemical compound relationship for UBE2B gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
halothane 33.7 3 8415876 (2), 7716787 (1)

Search CenterWatch for drugs/clinical trials and news about UBE2B 

Transcripts
for UBE2B gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section
REFSEQ mRNAs for UBE2B gene: 
NM_003337.2  

Unigene Clusters for UBE2B:

Ubiquitin-conjugating enzyme E2B
Hs.612096  [show with all ESTs], Hs.730071
Unigene Representative Sequences: NM_003337, BC001694
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000265339(uc003kzh.3) ENST00000510021 ENST00000511807 ENST00000506787
ENST00000507277 ENST00000504431 ENST00000499038 ENST00000503080

miRNA
Products:     		 OriGene 3'-UTR Clone: UBE2B
Browse OriGene MicroRNA Expression Plasmids
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBE2B
8/87 QIAGEN miScript miRNA Assays for microRNAs that regulate UBE2B (see all 87):
hsa-miR-323-3p hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-519a hsa-miR-3161 hsa-miR-890 hsa-miR-629*
SwitchGear 3'UTR luciferase reporter plasmid: UBE2B 3' UTR sequence
Inhib. RNA
Products:     		Browse for Gene Knock-down Tools from EMD Millipore
OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBE2B (see all 7)
OriGene shRNA RFP: UBE2B
OriGene siRNA: UBE2B
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBE2B
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBE2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
GenScript: all cDNA clones in your preferred vector: UBE2B (NM_003337)
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Primer
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2B

Additional cDNA sequence: BC001694.2 

20 DOTS entries:

DT.319282  DT.100808685  DT.100808677  DT.92439916  DT.97846777  DT.70101729  DT.92439905  DT.100044489 
DT.40121603  DT.100768866  DT.40133261  DT.100699719  DT.100808676  DT.100808679  DT.100808682  DT.86852750 
DT.92439919  DT.95104579  DT.95352653  DT.40133263 

24/314 AceView cDNA sequences (see all 314):

AW195838 BQ184035 CF127499 BF870395 BM976620 BM718879 BQ018092 BQ029935 
BG618151 AA490994 CA432625 BM680751 BU686894 CR625304 AA932687 AA552980 
NM_003337 BQ001089 BF593427 BU618038 BM993110 BM976022 CA427213 BQ229320 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for UBE2B    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e
SP1:                    -                       -                           
SP2:                    -     -                 -                           
SP3:                    -     -     -           -                           
SP4:                          -     -     -                                 


ECgene alternative splicing isoforms for UBE2B

Expression
for UBE2B gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBE2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCGCAGCT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

UBE2B expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
TestisSeminiferous TubulesSpermatidGerm Cells, Male Gametocytes
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See UBE2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBE2B

SOURCE GeneReport for Unigene clusters: Hs.612096 Hs.730071
    SABiosciences Expression via Pathway-Focused PCR Arrays including UBE2B: 
          Ubiquitination (Ubiquitylation) Pathway in human mouse rat
          Epigenetic Chromatin Modification Enzymes in human mouse rat

Primer
Products:		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for UBE2B
Browse OriGene validated miRNA SYBR primer pairs
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat UBE2B
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBE2B
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBE2B
In Situ
Assay Products: 
 		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBE2B

Orthologs
for UBE2B gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2B gene from 9/39 species (see all 39)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
chicken
(Gallus gallus)		 Aves LOC1008576781 ubiquitin-conjugating enzyme E2 B-like 90.1(n)
100(a)		   100857678  XM_003642086.1  XP_003642134.1 
lizard
(Anolis carolinensis)		 Reptilia UBE2B6
 --
 99(a)
 1 ↔ 1
 2(130932793-130945163)
African clawed frog
(Xenopus laevis)		 Amphibia Xl.174662 Xenopus laevis transcribed sequence with strong similarity more 84.98(n)    BX854470.1 
zebrafish
(Danio rerio)		 Actinopterygii wufc79h102 wufc79h10 80.92(n)   325470  BC044416.1 
fruit fly
(Drosophila melanogaster)		 Insecta UbcD63 DNA repair ubiquitin conjugating enzyme 86(a)   82E4   --
worm
(Caenorhabditis elegans)		 Secernentea ubc-13 ubiquitin conjugating-protein 84(a)   IV(4103222-4105426)   --
baker's yeast
(Saccharomyces cerevisiae)		 Saccharomycetes RAD61 Rad6p 64.02(n)
69.54(a)		   852822   NP_011457.1 
thale cress
(Arabidopsis thaliana)		 eudicotyledons UBC16
ATUBC26
(see all 3)		 ubiquitin-conjugating enzyme E2 A
(see all 3)		 75(a)
74(a)
(see all 3)		 many ↔ many
many ↔ many
(see all 3)		 1(4927011-4928690)
2(773684-775371)
rice
(Oryza sativa)		 Liliopsida --
--
(see all 3)		 ubiquitin-conjugating enzyme, putative, expressed
(see all 3)		 75(a)
74(a)
(see all 3)		 many ↔ many
many ↔ many
(see all 3)		 7(3585108-3592894)
5(4958237-4964937)


ENSEMBL Gene Tree for UBE2B (if available)
TreeFam Gene Tree for UBE2B (if available) 

Paralogs
for UBE2B gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for UBE2B gene
UBE2S2  UBE2O2  BIRC62  UBE2Z2  UBE2A2  
18/37 SIMAP similar genes for UBE2B using alignment to 4 protein entries:     UBE2B_HUMAN (see all proteins) (see all similar genes):
UBE2A    RHBG    HR6A    NLN    MST132    TUBA1C
RQCD1    UBE2D3    UBE2D4    UBE2D2    UBE2D1    UBE2N
UBE2E2    UBE2M    UBE2H    UBE2G2    UBE2E3    UBE2NL

UBE2B for paralogs           About GeneDecksing



Genomic Variants
for UBE2B gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/383 NCBI SNPs in UBE2B are shown (see all 383)     About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance		Chr 5 posSequence#AA
Chg		TypeMore#Allele
freq		PopTotal
sample		More
----------
rs721362341,2
C--128899197(+) ATGAC-/TTTTTTT 1 -- int10--------
rs351747081,2
C,--133705019(+) TTCCTT/CACCTC 1 -- us2k15Minor allele frequency- C:0.00NS 190
rs1868348631,2
--133705027(+) CTCTAC/TTGCCT 1 -- us2k10--------
rs1164942821,2
C,F,--133705056(+) ACTTCG/ATTGGT 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1450520271,2
--133705160(+) GCCCAC/TAGTTC 1 -- us2k10--------
rs7637431,2
H--133705274(+) TACAAG/CGGTTT 1 -- us2k17Minor allele frequency- C:0.00EA NA NS 470
rs38342751,2
C,F,--133705297(+) CGGGA-/TTTTTT 1 -- us2k16Minor allele frequency- T:0.22NS NA 186
rs1476294011,2
--133705416(+) GCCACA/CATGCC 1 -- us2k10--------
rs1915533121,2
--133705424(+) GCCTGA/GCTAAT 1 -- us2k10--------
rs1408884691,2
--133705473(+) GGCTGA/GTCTTC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for UBE2B (133706870 - 133727799 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for UBE2B
     1 Indel: 60560
Human Gene Mutation Database (HGMD): UBE2B

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBE2B
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Disorders / Diseases
for UBE2B gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
UBE2B for disorders           About GeneDecksing

OMIM gene information: 179095    OMIM disorders: --

12 diseases for UBE2B:    About MalaCards
edwards syndrome    male infertility    turner syndrome    papilloma
hepatitis c    infertility    azoospermia    vaccinia
hepatitis    breast cancer    hypoxia    malaria

1 disease from the University of Copenhagen DISEASES database for UBE2B:
Male infertility

4 Novoseek disease relationships for UBE2B gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
hepatitis halothane 81.3 3 8415876 (2), 7716787 (1)
mimicry 41.5 2 7716787 (1), 8415876 (1)
papilloma 33.7 5 10999461 (2), 10738224 (1)
tumors 0 1 10999461 (1)

Human Genome Epidemiology (HuGE) Navigator: UBE2B (3 documents)

Export disorders for UBE2B gene to outside databases

Publications
for UBE2B gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for UBE2B gene, integrated from 9 sources (see all 83):
(articles sorted by number of sources associating them with UBE2B)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. (PubMed id 1559696)1, 3, 9 Koken M.H....Hoeijmakers J.H. (1992)
  2. The human RAD18 gene product interacts with HHR6A and HHR6B. (PubMed id 10908344)1, 2, 9 Xin H.... Wang Z. (2000)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. (PubMed id 11885984)1, 2 Miura T.... Senn H. (2002)
  5. Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. (PubMed id 1717990)1, 2 Koken M.H.M.... Hoeijmakers J.H.J. (1991)
  6. Mammalian mRNAs encoding protein closely related to ubiquitin- conjugating enzyme encoded by yeast DNA repair gene RAD6. (PubMed id 1883845)1, 2 Woffendin C.... Plagemann P.G. (1991)
  7. The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6. (PubMed id 2158443)1, 2 Schneider R.... Schweiger M. (1990)
  8. Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. (PubMed id 17050667)1, 9 Shekhar M.P....Gerard B. (2006)
  9. RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. (PubMed id 14981545)1, 9 Lyakhovich A. and Shekhar M.P. (2004)
  10. Recognition of forked and single-stranded DNA structures by human RAD18 complexed with RAD6B protein triggers its recruitment to stalled replication forks. (PubMed id 18363965)1, 9 Tsuji Y....Tateishi S. (2008)

External Searches for UBE2B gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
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Genome Databases showing UBE2B gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 7320 HGNC: 12473 AceView: UBE2B Ensembl:ENSG00000119048 euGenes: HUgn7320
ECgene: UBE2B Kegg: 7320 H-InvDB: UBE2B

Other Databases showing UBE2B gene

(According to HUGE)
About This Section
   --

Specialized Databases showing UBE2B gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for UBE2B Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for UBE2B Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPshttp://egp.gs.washington.edu/data/ube2b/

Intellectual Property
for UBE2B gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for UBE2B gene:
Search GeneIP for patents involving UBE2B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



Products
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