Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



UBD Gene

protein-coding   GIFtS: 58
GCID: GC06M029525

Ubiquitin D

  See UBD-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Ubiquitin D1 2     UBD-32
FAT102 3 5     diubiquitin2
Ubiquitin-Like Protein FAT102 3     Diubiquitin3
GABBR12     

External Ids:    HGNC: 187951   Entrez Gene: 105372   Ensembl: ENSG000002138867   OMIM: 6060505   UniProtKB: O152053   

Export aliases for UBD gene to outside databases

Previous GC identifers: GC06M029580 GC06M029294 GC06M029632 GC06M029633 GC06M029634 GC06Mc29667 GC06M029330


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for UBD Gene:
UBD (ubiquitin D) is a protein-coding gene. Diseases associated with UBD include severe acute respiratory syndrome, and nephrosclerosis. GO annotations related to this gene include proteasome binding.

UniProtKB/Swiss-Prot: UBD_HUMAN, O15205
Function: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently
leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival
factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9
(PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity
NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for
TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in
dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent
antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome
instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the
kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the
formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent
manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease
and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN)

summary for UBD Gene:
GABAB receptors are metabotropic G-protein-coupled receptors responsible for mediating the inhibitory
effects of GABA alongside ionotropic GABAA and GABAC receptors. They exist as heterodimers of GABAB1 and
GABAB2 subunits and the presence of both subunits is required for receptor function. When GABAB1 is
expressed alone it is non-functional and is not transported to the cell membrane. The GABAB1 subunit is
responsible for binding GABA while the GABAB2 subunit interacts with the G protein. The two subunits
interact allosterically, GABA increases coupling of GABAB2 to G proteins and GABAB2 increases agonist
binding to GABAB1. GABAB receptors are coupled to Ca2+ and K+ channels.

Gene Wiki entry for UBD (Ubiquitin D) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000006.12  NC_018917.2  NT_007592.16  NT_113891.3  NT_167244.2  NT_167245.2  NT_167246.2  NT_167247.2  
NT_167248.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBD gene promoter:
         Nkx3-1   SREBP-1c   Egr-1   E47   SREBP-1b   Egr-2   Max   SREBP-1a   Hand1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBD promoter sequence
   Search Chromatin IP Primers for UBD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

UBD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBD gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M029525:  view genomic region     (about GC identifiers)

Start:
29,523,292 bp from pter      End:
29,527,702 bp from pter
Size:
4,411 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167245 826,740-831,053      Chr6-,NT_167247 826,601-830,914      Chr6-,NT_167244 826,901-831,215     
Chr6-,NT_167248 826,707-831,021      Chr6-,NT_113891.2 1,042,199-1,046,512      Chr6-,NT_167246 826,391-830,705     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: UBD_HUMAN, O15205 (See protein sequence)
Recommended Name: Ubiquitin D  
Size: 165 amino acids; 18473 Da
Subunit: Interact directly with the 26S proteasome. The interaction with NUB1L vie the N-terminal ubiquitin domain
facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own
degradation and that of its conjugates. Interacts with the spindle checkpoint protein MAD2L1 during mitosis.
Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions.
Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma
(IFNg)
Miscellaneous: Common types of chronic kidney disease are associated with tubulointerstitial up-regulation of
FAT10. FAT10 may mediate NF-kappa-B activation and may promote tubulointerstitial inflammation in chronic kidney
diseases
Secondary accessions: B0UZT6 Q5STL2 Q5SUK2 Q96EC7

Explore the universe of human proteins at neXtProt for UBD: NX_O15205

Explore proteomics data for UBD at MOPED

Post-translational modifications: 

  • Can be acetylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See UBD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006389.2  
    ENSEMBL proteins: 
     ENSP00000366249  

    UBD Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant UBD Protein
    R&D Systems Recombinant & Natural Proteins for UBD (FAT10)
    Enzo Life Sciences proteins for UBD
    OriGene Purified Protein for UBD
    OriGene Protein Over-expression Lysate for UBD
    OriGene MassSpec for UBD
    OriGene Custom Protein Services for UBD
    GenScript Custom Purified and Recombinant Proteins Services for UBD
    Novus Biologicals UBD Proteins
    Novus Biologicals UBD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for UBD
    Cloud-Clone Corp. Proteins for UBD

     
    Search eBioscience for Proteins for UBD 

    UBD Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UBD
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UBD
    OriGene Custom Antibody Services for UBD
    Novus Biologicals UBD Antibodies
    Abcam antibodies for UBD
    Cloud-Clone Corp. Antibodies for UBD
    Search ThermoFisher Antibodies for UBD
    LSBio Antibodies in human, mouse, rat for UBD

    UBD Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBD
    Cloud-Clone Corp. CLIAs for UBD
    Search eBioscience for ELISAs for UBD 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR000626 Ubiquitin_dom
     IPR019956 Ubiquitin

    Graphical View of Domain Structure for InterPro Entry O15205

    ProtoNet protein and cluster: O15205

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: UBD_HUMAN, O15205
    Similarity: Contains 2 ubiquitin-like domains


    Find genes that share domains with UBD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBD_HUMAN, O15205
    Function: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently
    leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival
    factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9
    (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity
    NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for
    TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in
    dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent
    antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome
    instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the
    kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the
    formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent
    manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease
    and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN)
    Induction: Rapidly degraded by the proteasome. Cell-cycle regulation with highest expression during the S-phase
    (at protein level). Induced during dendritic cell maturation. Negatively regulated by p53/TP53. High levels in
    various gastrointestinal and gynecological cancer cells. Induced in RTECs in common renal diseases including
    diabetic nephropathy (DN), IgA nephropathy (IgAN), and hypertensive nephrosclerosis (HN), as well as in
    hepatocellular carcinoma (HCC) and during HIVAN. Inducible by the proinflammatory cytokines IFNG/IFN-gamma and
    TNF in cancers of liver and colon. Repressed by NUB1L (at protein level)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10200259
    GO:0070628proteasome binding IDA16707496
         
    Find genes that share ontologies with UBD           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubd):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with UBD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ubdtm1Smwe for UBD

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBD
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBD
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBD

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBD:
    hsa-mir-24-3p (MIRT030468), hsa-mir-335-5p (MIRT017438)

    Block miRNA regulation of human, mouse, rat UBD using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UBD
    SwitchGear 3'UTR luciferase reporter plasmidUBD 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBD
    Predesigned siRNA for gene silencing in human, mouse, rat UBD

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBD

    Clone
    Products:
         
    OriGene clones in human, mouse for UBD (see all 6)
    OriGene ORF clones in mouse, rat for UBD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBD (NM_006398)
    Sino Biological Human cDNA Clone for UBD
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBD

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBD
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBD 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBD


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    UBD_HUMAN, O15205: Nucleus. Cytoplasm (By similarity). Note=Accumulates in aggresomes under proteasome
    inhibition conditions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    endosome1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12730673
    GO:0005737cytoplasm ISS--
    GO:0016235aggresome IDA19033385

    Find genes that share ontologies with UBD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for UBD About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1BRCA1 Pathway
    BRCA1 Pathway
    Fanconi's Anaemia Pathway0.00
    2NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    3PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    4TGF-Beta Pathway
    JAK-STAT Pathway0.57
    5TRAF Pathway
    TRAF Pathway0.42

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBD (see all 17)
        Remodeling of Adherens Junctions
    TRAF Pathway
    BRCA1 Pathway
    CDK5 Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBD
    Interactions:

        GeneGlobe Interaction Network for UBD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBD (O152053 ENSP000003662494) via UniProtKB, MINT, STRING, and/or I2D (see all 60)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN3P542523, ENSP000003523244I2D: score=1 STRING: ENSP00000352324
    HDAC6Q9UBN73, ENSP000003340614I2D: score=1 STRING: ENSP00000334061
    NUB1Q9Y5A73, ENSP000003986444I2D: score=1 STRING: ENSP00000398644
    PSMC3P179803, ENSP000002988524I2D: score=1 STRING: ENSP00000298852
    STAM2O758863, ENSP000002639044I2D: score=1 STRING: ENSP00000263904
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS9368598
    GO:0006511ubiquitin-dependent protein catabolic process IDA17889673
    GO:0010243response to organonitrogen compound IEA--
    GO:0016567protein ubiquitination IDA15831455
    GO:0032446protein modification by small protein conjugation NAS9368598

    Find genes that share ontologies with UBD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for UBD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CGP 35348 Brain penetrant, selective GABAB antagonist [123690-79-9]
    CGP 55845 hydrochloride Potent, selective GABAB antagonist [149184-22-5]
    SCH 50911 Selective, competitive, orally active GABAB antagonist [160415-07-6]
    CGP 52432 Potent, selective GABAB antagonist [139667-74-6]
    CGP 54626 hydrochloride Potent, selective GABAB antagonist [149184-21-4]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for UBD gene: 
    NM_006398.3  

    Unigene Cluster for UBD:

    Ubiquitin D
    Hs.44532  [show with all ESTs]
    Unigene Representative Sequence: NM_006398
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377050(uc003nmo.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBD using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate UBD
    SwitchGear 3'UTR luciferase reporter plasmidUBD 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBD
    Predesigned siRNA for gene silencing in human, mouse, rat UBD
    Clone
    Products:
         
    OriGene clones in human, mouse for UBD (see all 6)
    OriGene ORF clones in mouse, rat for UBD
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBD (NM_006398)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBD
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBD
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBD
    OriGene qSTAR qPCR primer pairs in human, mouse for UBD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBD
      QuantiTect SYBR Green Assays in human, mouse, rat UBD
      QuantiFast Probe-based Assays in human, mouse, rat UBD

    Additional mRNA sequence: 

    AF123050.1 AK311914.1 BC012472.1 Y12653.1 

    6 DOTS entries:

    DT.100645165  DT.112373  DT.121390472  DT.95359346  DT.92324520  DT.95368176 

    Selected AceView cDNA sequences (see all 255):

    BM126950 AW105586 BX111922 AW264022 BM929866 AJ012186 AJ225028 BF476724 
    AA742280 AU118171 BM710330 AJ225029 T81224 BX644916 NM_021903 CD630932 
    BC023336 BX280913 CB054344 AL602784 BU729438 W07715 BM661640 BG910376 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    UBD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTTACTA
    UBD Expression
    About this image


    UBD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Spleen (Hematopoietic System)
    UBD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.44532

    UniProtKB/Swiss-Prot: UBD_HUMAN, O15205
    Tissue specificity: Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the
    reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland

        Custom PCR Arrays for UBD
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for UBD
    OriGene qSTAR qPCR primer pairs in human, mouse for UBD
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBD
    QuantiTect SYBR Green Assays in human, mouse, rat UBD
    QuantiFast Probe-based Assays in human, mouse, rat UBD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBD gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubd1 , 5 ubiquitin D1, 5 74.28(n)1
    70.99(a)1
      17 (19.16 cM)5
    241081  NM_023137.31  NP_075626.11 
     371938925 
    lizard
    (Anolis carolinensis)
    Reptilia UBD6
    ubiquitin D
    42(a)
    1 ↔ 1
    LGb(1336411-1336527)
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubi-p63E6
    Ubiquitin-63E
    8(a)
    1 ↔ 1
    3L(3899259-3903184)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBI46
    Ubiquitin, becomes conjugated to proteins, marking...
    14(a)
    1 ↔ 1
    XII(64062-65207) YLL039C


    ENSEMBL Gene Tree for UBD (if available)
    TreeFam Gene Tree for UBD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for UBD gene
    5 SIMAP similar genes for UBD using alignment to 1 protein entry:     UBD_HUMAN:
    UBC    DKFZp434K0435    UBB    UbC    UBBP4

    Find genes that share paralogs with UBD           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for UBD
    PGOHUM00000243119


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for UBD (see all 160)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs92806181,2
    C--29446132(+) TTTTT-/TAGTTG 1 -- int10--------
    rs1815754201,2
    --29522900(+) TTGTTA/CGCTCC 1 -- int10--------
    rs1444822231,2
    C--29522993(+) ATCATC/GCCCAG 1 -- int10--------
    rs1395369301,2
    C--29523047(+) AGGGGA/GCATGG 1 -- int10--------
    rs1844725211,2
    --29523099(+) GGGGGA/GAAGGA 1 -- int10--------
    rs1451687451,2
    --29523276(+) ATACAA/GAAATC 1 -- int10--------
    rs1150791851,2
    C,F--29523342(+) TAGGAG/ATTTTT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1889205891,2
    C--29523439(+) TCAGTA/GATACA 1 -- ut310--------
    rs77395361,2
    C,F,A,H--29523472(+) ATTAAT/GTGTGT 1 -- ut317Minor allele frequency- G:0.02NS EA NA 880
    rs1812930711,2
    --29523592(+) GTGTTC/TGTTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBD (29523292 - 29527702 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5239CNV Loss18451855
    essv18215CNV CNV17122850
    dgv1908e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): UBD
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBD
    DNA2.0 Custom Variant and Variant Library Synthesis for UBD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606050    OMIM disorders: --

    2 diseases for UBD:    
    About MalaCards
    severe acute respiratory syndrome    nephrosclerosis


    Find genes that share disorders with UBD           About GenesLikeMe

    2 Novoseek inferred disease relationships for UBD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 6.02 7 12730673 (4), 10602013 (1), 16495226 (1)
    tumors 0 2 18280469 (1), 12730673 (1)

    Genetic Association Database (GAD): UBD
    Human Genome Epidemiology (HuGE) Navigator: UBD (7 documents)

    Export disorders for UBD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for UBD gene, integrated from 10 sources (see all 98):
    (articles sorted by number of sources associating them with UBD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells. (PubMed id 9368598)1, 2, 3 Bates E.E.M.... Lebecque S. (Eur. J. Immunol. 1997)
    2. Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers. (PubMed id 12730673)1, 2, 9 Lee C.G.L....Lee L.A. (Oncogene 2003)
    3. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. (PubMed id 10200259)1, 2, 9 Liu Y.-C....Weissman S.M. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    4. FAT10 plays a role in the regulation of chromosomal stability. (PubMed id 16495226)1, 2, 9 Ren J.... Lee C.G.L. (J. Biol. Chem. 2006)
    5. The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. (PubMed id 19033385)1, 2, 9 Kalveram B.... Groettrup M. (J. Cell Sci. 2008)
    6. Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. (PubMed id 16495380)1, 2, 9 Ross M.J.... Klotman P.E. (J. Am. Soc. Nephrol. 2006)
    7. A regulatory single nucleotide polymorphism in the ubiquitin D gene associated with celiac disease. (PubMed id 19808075)1, 4, 9 Castellanos-Rubio A....Bilbao J.R. (Hum. Immunol. 2010)
    8. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PubMed id 17971048)1, 4, 9 Burfoot R.K....Rubio J.P. (Tissue Antigens 2008)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Dorak M.T. (Mol. Hum. Reprod. 2010)
    10. The ubiquitin-like protein FAT10 mediates NF-kappa-B activation. (PubMed id 19959714)1, 2 Gong P.... Ross M.J. (J. Am. Soc. Nephrol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10537 HGNC: 18795 AceView: GABBR1andUBD Ensembl:ENSG00000213886 euGenes: HUgn10537
    ECgene: UBD H-InvDB: UBD

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for UBD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for UBD gene:
    Search GeneIP for patents involving UBD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Purified and/or Recombinant UBD Protein
     EMD Millipore Mono- and Polyclonal Antibodies for the study of UBD
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for UBD (FAT10)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for UBD   OriGene RNAi products in human, mouse, rat for UBD  
     OriGene qPCR primer pairs and template standards for UBD   OriGene Protein Over-expression Lysate for UBD  
     OriGene MassSpec something-or-other for UBD   OriGene clones in human, mouse for UBD  
     OriGene qSTAR qPCR primer pairs in human, mouse for UBD   OriGene Purified Protein for UBD  
     OriGene ORF clones in mouse, rat for UBD   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for UBD   OriGene Custom Protein Services for UBD  

     
     
     Block miRNA regulation of human, mouse, rat UBD using miScript Target Protectors SeqTarget long-range PCR primers for resequencing UBD
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBD Predesigned siRNA for gene silencing in human, mouse, rat UBD
     QuantiFast Probe-based Assays in human, mouse, rat UBD QuantiTect SYBR Green Assays in human, mouse, rat UBD
     Custom PCR Arrays for UBD Search Chromatin IP Primers for UBD
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBD  GeneGlobe Interaction Network for UBD
     Regulatory tfbs in UBD promoter
     GenScript Custom Purified and Recombinant Proteins Services for UBD GenScript cDNA clones with any tag delivered in your preferred vector for UBD
     GenScript Custom Assay Services for UBD GenScript Custom overexpressing Cell Line Services for UBD
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for UBD
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for UBD
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Proteins for UBD
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     UBD antibodies
     UBD proteins
     UBD lysates
     Antibodies for UBD
     See all of Abcam's Antibodies, Kits and Proteins for UBD
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for UBD
     Proteins for UBD
     Antibodies for UBD
     ELISAs for UBD
     CLIAs for UBD



     Browse ESI BIO Cell Lines and PureStem Progenitors for UBD
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBD
     SwitchGear 3'UTR luciferase reporter plasmids for UBD
     SwitchGear Promoter luciferase reporter plasmids for UBD
     Search ThermoFisher Antibodies for UBD
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBD
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBD
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBD
     LSBio Antibodies in human, mouse, rat for UBD
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for UBD
      Search eBioscience for proteins for UBD
      Search eBioscience for elisas for UBD
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      UBD gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4