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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBD Gene

protein-coding GIFtS: 57
GCID: GC06M029525

ubiquitin D

Explore 26 diseases affiliated with
UBD via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin D¹ ²		UBD-3²
FAT10¹ ² ³ ⁵		Diubiquitin³
Ubiquitin-Like Protein FAT10² ³		Diubiquitin³
GABBR1²

External Ids:	HGNC: 18795¹	Entrez Gene: 10537²	Ensembl: ENSG00000213886⁷	OMIM: 606050⁵	UniProtKB: O15205³

Export aliases for UBD gene to outside databases

Previous GC identifers: GC06M029580 GC06M029294 GC06M029632 GC06M029633 GC06M029634 GC06Mc29667 GC06M029330

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UBD_HUMAN, O15205

Function: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to

their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival factor.

Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2).

Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by

promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced

p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC)

maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells

that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro

culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the

prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or

impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during

renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN)

summary for UBD:

GABAB receptors are metabotropic G-protein-coupled receptors responsible for mediating the inhibitory

effects of GABA alongside ionotropic GABAA and GABAC receptors. They exist as heterodimers of GABAB1 and

GABAB2 subunits and the presence of both subunits is required for receptor function. When GABAB1 is

expressed alone it is non-functional and is not transported to the cell membrane. The GABAB1 subunit is

responsible for binding GABA while the GABAB2 subunit interacts with the G protein. The two subunits

interact allosterically, GABA increases coupling of GABAB2 to G proteins and GABAB2 increases agonist

binding to GABAB1. GABAB receptors are coupled to Ca2+ and K+ channels.

Gene Wiki entry for UBD (Ubiquitin D)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167244.1 NT_167245.1 NT_167246.1 NT_167247.1

NT_167248.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBD gene promoter:
Nkx3-1 SREBP-1c Egr-1 E47 SREBP-1b Egr-2 Max SREBP-1a Hand1 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBD promoter sequence

Search SABiosciences Chromatin IP Primers for UBD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p22.1 HGNC cytogenetic band: 6p21.3

UBD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBD gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M029525: view genomic region (about GC identifiers)

Start:	29,523,292 bp from pter	End:	29,527,702 bp from pter
Size:	4,411 bases	Orientation:	minus strand

6 alternative locations:

Chr6-,ALT_REF_LOCI_5 29,438,024-29,442,337	Chr6-,ALT_REF_LOCI_3 29,523,343-29,538,694	Chr6-,ALT_REF_LOCI_2 29,519,995-29,563,496
Chr6-,ALT_REF_LOCI_4 29,446,050-29,450,364	Chr6-,ALT_REF_LOCI_1 29,523,504-29,536,118	Chr6-,ALT_REF_LOCI_6 29,523,310-29,563,205

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBD_HUMAN, O15205 (See protein sequence)

Recommended Name: Ubiquitin D

Size: 165 amino acids; 18473 Da

Subunit: Interact directly with the 26S proteasome. The interaction with NUB1L vie the N-terminal ubiquitin domain

facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own degradation

and that of its conjugates. Interacts with the spindle checkpoint protein MAD2L1 during mitosis. Present in aggresomes

of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions. Forms a thioester with

UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma (IFNg)

Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Accumulates in aggresomes under proteasome inhibition

conditions

Miscellaneous: Common types of chronic kidney disease are associated with tubulointerstitial up-regulation of FAT10.

FAT10 may mediate NF-kappa-B activation and may promote tubulointerstitial inflammation in chronic kidney diseases

Secondary accessions: B0UZT6 Q5STL2 Q5SUK2 Q96EC7

Explore the universe of human proteins at neXtProt for UBD: NX_O15205

Post-translational modifications:

Can be acetylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15205

UBD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006389.2

ENSEMBL proteins:

ENSP00000366249

Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant UBD Protein
	R&D Systems Recombinant & Natural Proteins for UBD (FAT10)
	Enzo Life Sciences proteins for UBD
	OriGene Purified Protein: UBD OriGene Protein Over-expression Lysate: UBD OriGene Custom Protein Services for UBD
	GenScript Custom Purified and Recombinant Proteins Services for UBD
	Novus Biologicals UBD Proteins Novus Biologicals UBD Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for UBD
	Uscn Proteins for UBD

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	12730673
GO:0005737	cytoplasm	ISS	--
GO:0016235	aggresome	IDA	19033385

UBD for ontologies About GeneDecksing

UBD Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: UBD OriGene Custom Antibody Services for UBD
	GenScript Superior Antibodies for UBD
	Novus Biologicals UBD Antibodies
	Abcam antibodies for UBD
	Uscn Antibodies for UBD
	Search ThermoFisher Antibodies for UBD

Assay Products for UBD:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for UBD
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for UBD

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBD for domains About GeneDecksing

3 InterPro domains/families:

IPR019956 Ubiquitin_subgr

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry O15205

ProtoNet protein and cluster: O15205

1 Blocks protein family: IPB000626 Ubiquitin domain

UniProtKB/Swiss-Prot: UBD_HUMAN, O15205

Similarity: Contains 2 ubiquitin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: