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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBD Gene

protein-coding   GIFtS: 58
GCID: GC06M029525

Ubiquitin D

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin D1 2     UBD-32
FAT102 3 5     diubiquitin2
Ubiquitin-Like Protein FAT102 3     Diubiquitin3
GABBR12     

External Ids:    HGNC: 187951   Entrez Gene: 105372   Ensembl: ENSG000002138867   OMIM: 6060505   UniProtKB: O152053   

Export aliases for UBD gene to outside databases

Previous GC identifers: GC06M029580 GC06M029294 GC06M029632 GC06M029633 GC06M029634 GC06Mc29667 GC06M029330


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBD Gene: 
UBD (ubiquitin D) is a protein-coding gene. Diseases associated with UBD include nephrosclerosis, and severe acute respiratory syndrome, and among its related super-pathways are NF-KappaB Family Pathway and MIF Regulation of Innate Immune Cells. GO annotations related to this gene include proteasome binding and protein binding. An important paralog of this gene is ISG15.

UniProtKB/Swiss-Prot: UBD_HUMAN, O15205
Function: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently
leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival
factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9
(PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity
NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for
TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in
dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent
antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome
instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the
kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the
formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent
manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease
and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN)

summary for UBD Gene:
GABAB receptors are metabotropic G-protein-coupled receptors responsible for mediating the inhibitory
effects of GABA alongside ionotropic GABAA and GABAC receptors. They exist as heterodimers of GABAB1 and
GABAB2 subunits and the presence of both subunits is required for receptor function. When GABAB1 is
expressed alone it is non-functional and is not transported to the cell membrane. The GABAB1 subunit is
responsible for binding GABA while the GABAB2 subunit interacts with the G protein. The two subunits
interact allosterically, GABA increases coupling of GABAB2 to G proteins and GABAB2 increases agonist
binding to GABAB1. GABAB receptors are coupled to Ca2+ and K+ channels.

Gene Wiki entry for UBD (Ubiquitin D) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  
NT_167248.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBD gene promoter:
         Nkx3-1   SREBP-1c   Egr-1   E47   SREBP-1b   Egr-2   Max   SREBP-1a   Hand1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBD promoter sequence
   Search SABiosciences Chromatin IP Primers for UBD

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p22.1   HGNC cytogenetic band: 6p21.3

UBD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBD gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M029525:  view genomic region     (about GC identifiers)

Start:
29,523,292 bp from pter      End:
29,527,702 bp from pter
Size:
4,411 bases      Orientation:
minus strand

6 alternative locations:
Chr6-,NT_167245 826,740-831,053      Chr6-,NT_113891.2 1,042,199-1,046,512      Chr6-,NT_167248 826,707-831,021     
Chr6-,NT_167246 826,391-830,705      Chr6-,NT_167247 826,601-830,914      Chr6-,NT_167244 826,901-831,215     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBD_HUMAN, O15205 (See protein sequence)
Recommended Name: Ubiquitin D  
Size: 165 amino acids; 18473 Da
Subunit: Interact directly with the 26S proteasome. The interaction with NUB1L vie the N-terminal ubiquitin domain
facilitates the linking of UBD-conjugated target protein to the proteasome complex and accelerates its own
degradation and that of its conjugates. Interacts with the spindle checkpoint protein MAD2L1 during mitosis.
Present in aggresomes of proteasome inhibited cells. Interacts with HDAC6 under proteasome impairment conditions.
Forms a thioester with UBA6 in cells stimulated with tumor necrosis factor-alpha (TNFa) and interferon-gamma
(IFNg)
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Accumulates in aggresomes under proteasome
inhibition conditions
Miscellaneous: Common types of chronic kidney disease are associated with tubulointerstitial up-regulation of
FAT10. FAT10 may mediate NF-kappa-B activation and may promote tubulointerstitial inflammation in chronic kidney
diseases
Secondary accessions: B0UZT6 Q5STL2 Q5SUK2 Q96EC7

Explore the universe of human proteins at neXtProt for UBD: NX_O15205

Explore proteomics data for UBD at MOPED 

Post-translational modifications:

  • UniProtKB: Can be acetylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15205

  • UBD Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    UBD Protein Expression
    REFSEQ proteins: NP_006389.2  
    ENSEMBL proteins: 
     ENSP00000366249  

    Human Recombinant Protein Products for UBD: 
    EMD Millipore Purified and/or Recombinant UBD Protein
    R&D Systems Recombinant & Natural Proteins for UBD (FAT10)
    Enzo Life Sciences proteins for UBD
    OriGene Purified Protein for UBD
    OriGene Protein Over-expression Lysate for UBD
    OriGene MassSpec for UBD 
    OriGene Custom Protein Services for UBD
    GenScript Custom Purified and Recombinant Proteins Services for UBD
    Novus Biologicals UBD Proteins
    Novus Biologicals UBD Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for UBD
    Cloud-Clone Corp. Proteins for UBD 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA12730673
    GO:0005737cytoplasm ISS--
    GO:0016235aggresome IDA19033385

    UBD for ontologies           About GeneDecksing



    UBD Antibody Products: 
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    Novus Biologicals UBD Antibodies
    Abcam antibodies for UBD
    Cloud-Clone Corp. Antibodies for UBD 
    Search ThermoFisher Antibodies for UBD
    LSBio Antibodies in human, mouse, rat for UBD 

    Assay Products for UBD: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBD
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBD
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for UBD 
    Cloud-Clone Corp. CLIAs for UBD


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR019956 Ubiquitin_subgr
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry O15205

    ProtoNet protein and cluster: O15205

    1 Blocks protein domain: IPB000626 Ubiquitin domain

    UniProtKB/Swiss-Prot: UBD_HUMAN, O15205
    Similarity: Contains 2 ubiquitin-like domains


    UBD for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBD_HUMAN, O15205
    Function: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently
    leads to their degradation by the 26S proteasome, in a NUB1L-dependent manner. Probably functions as a survival
    factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9
    (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity
    NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for
    TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in
    dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent
    antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome
    instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the
    kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the
    formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent
    manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease
    and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN)
    Induction: Rapidly degraded by the proteasome. Cell-cycle regulation with highest expression during the S-phase
    (at protein level). Induced during dendritic cell maturation. Negatively regulated by p53/TP53. High levels in
    various gastrointestinal and gynecological cancer cells. Induced in RTECs in common renal diseases including
    diabetic nephropathy (DN), IgA nephropathy (IgAN), and hypertensive nephrosclerosis (HN), as well as in
    hepatocellular carcinoma (HCC) and during HIVAN. Inducible by the proinflammatory cytokines IFNG/IFN-gamma and
    TNF in cancers of liver and colon. Repressed by NUB1L (at protein level)

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10200259
    GO:0070628proteasome binding IDA16707496
         
    UBD for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubd):
     cellular  immune system 

    UBD for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ubdtm1Smwe for UBD

       inGenious Targeting Laboratory - Custom generated mouse model solutions for UBD 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for UBD

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBD 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBD 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBD
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UBD
    SwitchGear 3'UTR luciferase reporter plasmidUBD 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for UBD
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBD

    Gene Editing
    Products:
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    Sirion Biotech Customized adenovirus for overexpression of UBD

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for UBD (see all 7)
    OriGene ORF clones in mouse, rat for UBD
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    GenScript: all cDNA clones in your preferred vector: UBD (NM_006398)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBD


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for UBD About   (see all 18)                                                                                              See pathways by source

    SuperPathContained pathways About
    1NF-KappaB Family Pathway
    NF-KappaB (p50-p65) Pathway0.72
    2PEDF Induced Signaling
    RAR-Gamma-RXR-Alpha Degradation0.62
    3TGF-Beta Pathway
    JAK-STAT Pathway0.57
    4Fanconi Anemia pathway
    Fanconi's Anaemia Pathway0.43
    5TRAF Pathway
    TRAF Pathway0.42

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for UBD
        Selected targets of p53

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBD (see all 17)
        Remodeling of Adherens Junctions
    TRAF Pathway
    BRCA1 Pathway
    CDK5 Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)



    UBD for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    5/16 Interacting proteins for UBD (O152053 ENSP000003662494) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HDAC6Q9UBN73, ENSP000003340614I2D: score=1 STRING: ENSP00000334061
    NUB1Q9Y5A73, ENSP000003986444I2D: score=1 STRING: ENSP00000398644
    PSMC3P179803, ENSP000002988524I2D: score=1 STRING: ENSP00000298852
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    MAD2L1Q132573, ENSP000002965094I2D: score=3 STRING: ENSP00000296509
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS9368598
    GO:0006511ubiquitin-dependent protein catabolic process IDA17889673
    GO:0010243response to organonitrogen compound IEA--
    GO:0016567protein ubiquitination IDA15831455
    GO:0032446protein modification by small protein conjugation NAS9368598

    UBD for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for UBD available from Tocris Bioscience    About this table
    CompoundAction CAS #
    CGP 35348 Brain penetrant, selective GABAB antagonist [123690-79-9]
    CGP 55845 hydrochloride Potent, selective GABAB antagonist [149184-22-5]
    SCH 50911 Selective, competitive, orally active GABAB antagonist [160415-07-6]
    CGP 52432 Potent, selective GABAB antagonist [139667-74-6]
    CGP 54626 hydrochloride Potent, selective GABAB antagonist [149184-21-4]

    Search CenterWatch for drugs/clinical trials and news about UBD

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for UBD gene: 
    NM_006398.3  

    Unigene Cluster for UBD:

    Ubiquitin D
    Hs.44532  [show with all ESTs]
    Unigene Representative Sequence: NM_006398
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377050(uc003nmo.3)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBD
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate UBD
    SwitchGear 3'UTR luciferase reporter plasmidUBD 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: UBD (NM_006398)
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                         Customized lentivirus expression plasmids for stable overexpression of UBD 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBD

    Additional mRNA sequence: 

    AF123050.1 AK311914.1 BC012472.1 Y12653.1 

    6 DOTS entries:

    DT.100645165  DT.112373  DT.121390472  DT.95359346  DT.92324520  DT.95368176 

    24/255 AceView cDNA sequences (see all 255):

    BX280913 CF552729 AJ225029 AA742280 CD630932 BM702959 AU280038 BF476724 
    NM_001470 AU118171 AJ225028 BM661640 BM726324 BG818076 BX090421 NM_021904 
    AI741552 CB054344 AL119755 BX111922 BM717516 BC023336 AJ012185 AA583465 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBD expression in normal human tissues (normalized intensities)      UBD embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTTTTACTA
    UBD Expression
    About this image


    UBD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             PureStem endothelial Progenitor 30-SM2-3
             Human Intestinal Microvascular Endothelial Cells (HIMEC)   
     
     Lymph (Cardiovascular System)    fully expand to see all 2 entries
             Human Lymphatic Endothelial Cells (HLEC)   
             lymph node   
     
     Intestine
             Human Intestinal Microvascular Endothelial Cells (HIMEC)   
     
     Liver (Hepatobiliary System)
             Human Hepatocyte (HH)   
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells

    See UBD Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBD

    SOURCE GeneReport for Unigene cluster: Hs.44532

    UniProtKB/Swiss-Prot: UBD_HUMAN, O15205
    Tissue specificity: Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the
    reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland

        SABiosciences Custom PCR Arrays for UBD
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for UBD gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubd1 , 5 ubiquitin D1, 5 75.64(n)1
    73.08(a)1
      17 (19.16 cM)5
    241081  NM_023137.31  NP_075626.11 
     371938925 
    worm
    (Caenorhabditis elegans)
    Secernentea F52C6.46
    F52C6.36
    (see all 3)
    Protein F52C6.3
    (see all 3)
    18(a)
    15(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    II(1923147-1923705)
    II(1924757-1925716)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBI46
    Ubiquitin, becomes conjugated to proteins, marking...
    13(a)
    1 → many
    XII(64062-65207)


    ENSEMBL Gene Tree for UBD (if available)
    TreeFam Gene Tree for UBD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBD gene
    ISG152  
    5 SIMAP similar genes for UBD using alignment to 2 protein entries:     UBD_HUMAN (see all proteins):
    UBC    DKFZp434K0435    UBB    UbC    UBBP4

    UBD for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for UBD
    PGOHUM00000243119


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/160 SNPs in UBD are shown (see all 160)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs92806181,2
    C--29446132(+) TTTTT-/TAGTTG 1 -- int10--------
    rs1815754201,2
    --29522900(+) TTGTTA/CGCTCC 1 -- int10--------
    rs1444822231,2
    C--29522993(+) ATCATC/GCCCAG 1 -- int10--------
    rs1395369301,2
    C--29523047(+) AGGGGA/GCATGG 1 -- int10--------
    rs1844725211,2
    --29523099(+) GGGGGA/GAAGGA 1 -- int10--------
    rs1451687451,2
    --29523276(+) ATACAA/GAAATC 1 -- int10--------
    rs1150791851,2
    C,F--29523342(+) TAGGAG/ATTTTT 1 -- int11Minor allele frequency- A:0.03NA 120
    rs1889205891,2
    C--29523439(+) TCAGTA/GATACA 1 -- ut310--------
    rs77395361,2
    C,F,A,H--29523472(+) ATTAAT/GTGTGT 1 -- ut317Minor allele frequency- G:0.02NS EA NA 880
    rs1812930711,2
    --29523592(+) GTGTTC/TGTTGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for UBD (29523292 - 29527702 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBD:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv5239CNV Loss18451855
    essv18215CNV CNV17122850
    dgv1908e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): UBD
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing UBD
    DNA2.0 Custom Variant and Variant Library Synthesis for UBD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606050    OMIM disorders: --

    20/26 diseases for UBD (see all 26):    About MalaCards
    nephrosclerosis    severe acute respiratory syndrome    cystitis    kidney disease
    polycystic kidney disease    celiac disease    intrahepatic cholangiocarcinoma    cholangiocarcinoma
    huntington's disease    inflammatory bowel disease    type 1 diabetes    systemic lupus erythematosus
    parkinson's disease    multiple sclerosis    lupus erythematosus    blindness
    hepatitis b    crohn's disease    hepatocellular carcinoma    adenoma


    UBD for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for UBD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 6.02 7 12730673 (4), 10602013 (1), 16495226 (1)
    tumors 0 2 18280469 (1), 12730673 (1)

    Genetic Association Database (GAD): UBD
    Human Genome Epidemiology (HuGE) Navigator: UBD (7 documents)

    Export disorders for UBD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBD gene, integrated from 9 sources (see all 96):
    (articles sorted by number of sources associating them with UBD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and analysis of a novel member of the ubiquitin family expressed in dendritic cells and mature B cells. (PubMed id 9368598)1, 2, 3 Bates E.E.M.... Lebecque S. (1997)
    2. Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers. (PubMed id 12730673)1, 2, 9 Lee C.G....Lee L.A. (2003)
    3. A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2. (PubMed id 10200259)1, 2, 9 Liu Y.-C....Weissman S.M. (1999)
    4. FAT10 plays a role in the regulation of chromosomal stability. (PubMed id 16495226)1, 2, 9 Ren J....Lee C.G. (2006)
    5. The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. (PubMed id 19033385)1, 2, 9 Kalveram B....Groettrup M. (2008)
    6. Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. (PubMed id 16495380)1, 2, 9 Ross M.J....Klotman P.E. (2006)
    7. A regulatory single nucleotide polymorphism in the ub iquitin D gene associated with celiac disease. (PubMed id 19808075)1, 4, 9 Castellanos-Rubio A....Bilbao J.R. (2010)
    8. SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians. (PubMed id 17971048)1, 4, 9 Burfoot R.K....Rubio J.P. (2008)
    9. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    10. The ubiquitin-like protein FAT10 mediates NF-kappaB a ctivation. (PubMed id 19959714)1, 2 Gong P....Ross M.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10537 HGNC: 18795 AceView: GABBR1andUBD Ensembl:ENSG00000213886 euGenes: HUgn10537
    ECgene: UBD H-InvDB: UBD

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBD Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBD Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for UBD gene:
    Search GeneIP for patents involving UBD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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