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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBC Gene

protein-coding   GIFtS: 66
GCID: GC12M125396

ubiquitin C
 Explore 119 diseases affiliated with
UBC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UBC    

Aliases
for UBC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin C1 2
HMG202
Polyubiquitin-C1

External Ids:    HGNC: 124681   Entrez Gene: 73162   Ensembl: ENSG000001509917   OMIM: 1913405   UniProtKB: P0CG483   

Export aliases for UBC gene to outside databases

Previous GC identifers: GC12M124151 GC12M125142 GC12M123749 GC12M123921 GC12M122360


Summaries
for UBC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UBC:
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of
ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin
is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase
modification, endocytosis, and regulation of other cell signaling pathways. (provided by RefSeq, Aug 2010)

UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,
it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via
different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the
ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different
functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair;
Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation;
Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is
involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as
well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains
formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of
target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is
free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in
signaling

Gene Wiki entry for UBC (Ubiquitin C)


Genomic Views
for UBC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009755.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBC gene promoter:
         Max1   AP-2alpha isoform 3   Sp1   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   MRF-2   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBC promoter sequence
   Search SABiosciences Chromatin IP Primers for UBC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.3

UBC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBC gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M125396:  view genomic region     (about GC identifiers)

Start:
 125,396,150 bp from pter      End:
 125,401,914 bp from pter
Size:
 5,765 bases      Orientation:
 minus strand

Proteins
for UBC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48 (See protein sequence)
Recommended Name: Polyubiquitin-C precursor  
Size: 685 amino acids; 77039 Da
Subcellular location: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)
Miscellaneous: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin
fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with
exact head to tail repeats, the number of repeats differ between species and strains
Miscellaneous: For the sake of clarity sequence features are annotated only for the first chain, and are not repeated
for each of the following chains
6/129 PDB 3D structures from and Proteopedia for UBC (see all 129):
1C3T (3D)        1CMX (3D)        1D3Z (3D)        1F9J (3D)        1FXT (3D)        1G6J (3D)    
Secondary accessions: P02248 P02249 P02250 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6
Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Explore the universe of human proteins at neXtProt for UBC: NX_P0CG48

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P0CG48

    • UBC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066289.2  
    ENSEMBL proteins: 
     ENSP00000441543   ENSP00000442456   ENSP00000443053   ENSP00000445033   ENSP00000445320  
     ENSP00000344818   ENSP00000442173   ENSP00000440205   ENSP00000442800   ENSP00000445337  
     ENSP00000439492   ENSP00000438289   ENSP00000441238   ENSP00000437452   ENSP00000441556  
     ENSP00000438394  
    Reactome Protein details: P0CG48
    Human Recombinant Protein Products: 
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    Enzo Life Sciences proteins for UBC
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for UBC 
    GenScript Custom Purified and Recombinant Proteins Services for UBC
    Novus Biologicals UBC Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UBC

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--
    GO:0030666endocytic vesicle membrane TAS--


    UBC for ontologies           About GeneDecksing



    UBC Antibody Products: 
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    Uscn Antibodies for UBC
    ThermoFisher Antibodies for UBC

    Assay Products for UBC: 
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    Uscn ELISAs and CLIAs for UBC

    Protein Domains /
    Families
    for UBC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UBC for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR019956 Ubiquitin_subgr
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup

    Graphical View of Domain Structure for InterPro Entry P0CG48

    ProtoNet protein and cluster: P0CG48

    UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48
    Similarity: Belongs to the ubiquitin family
    Similarity: Contains 9 ubiquitin-like domains


    Function
    for UBC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48
    Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,
    it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via
    different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the
    ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different
    functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair;
    Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation;
    Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is
    involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as
    well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains
    formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of
    target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is
    free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in
    signaling

         Genatlas biochemistry entry for UBC:
    poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBC
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate UBC (see all 11):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBC (see all 4)
    OriGene shRNA RFP: UBC
    OriGene siRNA: UBC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for UBC

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for UBC (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBC
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: UBC (NM_021009)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBC 

    Cell Line
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    Search LifeMap BioReagents cell lines for UBC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBC

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI--
    GO:0005515protein binding IPI19285159


    UBC for ontologies           About GeneDecksing


    9 GenomeRNAi human phenotypes for UBC:
     Cell division defect  Decreased cell number, increas  Decreased homologous recombina  Decreased nuclei size in G2M 
     Decreased viability of wild-ty  Increased cell death HMECs cel  Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Ubctm11Rrk for UBC
         6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ubc):
     cellular  embryogenesis  growth/size  hematopoietic system  liver/biliary system 
     mortality/aging 

    UBC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UBC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/88 super-pathways (see all 88) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ubiquitinated Orc1 is degraded by the proteasome
    8/70 pathways (see all 70)
    		Ubiquitinated Orc1 is degraded by the proteasome1.00
    		APC/C:Cdc20 mediated degradation of Securin0.74
    		Proteasomal cleavage of substrate0.98
    		Degradation of multiubiquitinated Securin0.74
    		Proteasome mediated degradation of PAK-2p340.98
    		ER-Phagosome pathway0.74
    		Proteasomal cleavage of substrate0.98
    		Activation of NF-kappaB in B Cells0.72
    2Signal Transduction
    8/34 pathways (see all 34)
    		Signal Transduction1.00
    		Degradation of ubiquitinated SKI/SKIL0.67
    		Signaling by NOTCH1.00
    		Ubiquitination of CRY Proteins0.57
    		Signaling by NOTCH1 HD Domain Mutants in Cancer1.00
    		Degradation of SMAD2/3:SMAD4 complex0.57
    		Ubiquitination of PAK-2p341.00
    		STING mediated induction of type 1 IFN0.50
    3TRAF6 Mediated Induction of proinflammatory cytokines
    8/19 pathways (see all 19)
    		TRAF6 Mediated Induction of proinflammatory cytokines1.00
    		Toll Like Receptor TLR1:TLR2 Cascade0.78
    		MAP kinase activation in TLR cascade0.88
    		Toll Like Receptor 2 (TLR2) Cascade0.78
    		Toll Like Receptor 5 (TLR5) Cascade0.86
    		MyD88:Mal cascade initiated on plasma membrane0.78
    		Toll Like Receptor 10 (TLR10) Cascade0.86
    		TRIF-mediated TLR3/TLR4 signaling 0.73
    4Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant
    8/11 pathways (see all 11)
    		Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant1.00
    		Signaling by NOTCH11.00
    		Signaling by NOTCH1 PEST Domain Mutants in Cancer1.00
    		Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    		Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer1.00
    		Signaling by NOTCH0.77
    		Signaling by NOTCH1 in Cancer1.00
    		Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.71
    5Signaling by FGFR
    		Signaling by FGFR1.00
    		Signaling by EGFR0.84
    		Signaling by FGFR in disease0.91
    		Signaling by EGFR in Cancer0.83
    		Signaling by ERBB20.89
    		Signalling by NGF0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBC (see all 17)
        Remodeling of Adherens Junctions
    TRAF Pathway
    BRCA1 Pathway
    CDK5 Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)

    5/23 GeneGo (Thomson Reuters) Pathways for UBC (see all 23)
        Normal wtCFTR traffic / Sorting endosome formation
    Proteolysis Putative ubiquitin pathway
    Immune response MIF-JAB1 signaling
    Regulation of degradation of wt-CFTR
    Immune response IL-12 signaling pathway

    2 BioSystems Pathways for UBC 
        Proteasome Degradation
    DNA Replication

    5/242        Reactome Pathways for UBC (see all 242)
        NOTCH1 Intracellular Domain Regulates Transcription
    TGF-beta receptor signaling activates SMADs
    Toll Like Receptor 2 (TLR2) Cascade
    Proteolytic degradation of ubiquitinated-Cdc25A
    Activated TRAF6 synthesizes unanchored polyubiquitin chains


    1         Kegg Pathway  (Kegg details for UBC):
        PPAR signaling pathway


    UBC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/7169 Interacting proteins for UBC (P0CG482, 3 ENSP000003448184) via UniProtKB, MINT, STRING, and/or I2D (see all 7169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMD4P550362, 3, ENSP000003578794MINT-7308936 MINT-50198 MINT-7308992 MINT-7309088 MINT-50256 MINT-7299166 MINT-7309023 MINT-7261503 MINT-7309056 MINT-50255 MINT-7309110 I2D: score=11 STRING: ENSP00000357879
    ADRM1Q161862, 3, ENSP000002530034MINT-7310443 MINT-7310399 MINT-7310429 MINT-7310499 MINT-7310471 MINT-7904643 MINT-7310415 MINT-7309220 MINT-7310485 MINT-7310457 I2D: score=2 STRING: ENSP00000253003
    HGSO149642, 3, ENSP000003312014MINT-50269 MINT-50283 MINT-50270 MINT-19113 MINT-50265 MINT-50292 MINT-50293 MINT-50284 I2D: score=4 STRING: ENSP00000331201
    TP53P046372, 3, ENSP000002693054MINT-7220023 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-7299234 MINT-7298704 MINT-6799774 MINT-7013815 MINT-4052207 MINT-7219995 MINT-5114741 I2D: score=5 STRING: ENSP00000269305
    HIST1H4CP628053, ENSP000003670344I2D: score=5 STRING: ENSP00000367034
    About this table

    Gene Ontology (GO): 5/69 biological process terms (GO ID links to tree view) (see all 69):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000075cell cycle checkpoint TAS--
    GO:0000080G1 phase of mitotic cell cycle TAS--
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000084S phase of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--


    UBC for ontologies           About GeneDecksing



    Drugs & Compounds
    for UBC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBC for compounds           About GeneDecksing

    EMD Millipore small molecules for UBC:
    Small Molecule - inhibitor
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    Browse Tocris compounds for UBC

    1 DrugBank Compound for UBC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Formylmethionine-- --target--10592235

    3 Novoseek chemical compound relationships for UBC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    finrozole 90.5 1 14982857 (1)
    porphobilinogen 52.2 1 16458257 (1)
    dexamethasone 0 4 11872750 (3), 16954342 (1)

    Search CenterWatch for drugs/clinical trials and news about UBC 

    Transcripts
    for UBC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UBC gene: 
    NM_021009.5  

    Unigene Cluster for UBC:

    Ubiquitin C
    Hs.520348  [show with all ESTs]
    Unigene Representative Sequence: AB209782
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536769(uc021rge.1) ENST00000535460(uc001ugu.1) ENST00000538617
    ENST00000536834 ENST00000541046 ENST00000339647(uc001ugs.4 uc001ugt.3 uc001ugv.3 uc001ugw.3)
    ENST00000544656 ENST00000541272 ENST00000540351(uc009zyf.1) ENST00000541645
    ENST00000535131 ENST00000544481 ENST00000546271 ENST00000540700 ENST00000535859
    ENST00000536661 ENST00000542416 ENST00000546120

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBC
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate UBC (see all 11):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBC (see all 4)
    OriGene shRNA RFP: UBC
    OriGene siRNA: UBC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBC
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for UBC
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    GenScript: all cDNA clones in your preferred vector: UBC (NM_021009)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBC 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat UBC

    Additional cDNA sequence: 

    AB009010.1 AB209782.1 AF052164.1 AK026846.1 AK056939.1 AK097415.1 AK098827.1 AK129749.1 
    AK291539.1 AL117514.1 AY732488.1 AY819759.1 BC000449.2 BC008955.2 BC014880.1 BC039193.1 
    BC080583.1 BC093445.1 M17597.1 

    24/204 DOTS entries (see all 204):

    DT.100892635  DT.100892528  DT.91842147  DT.100892593  DT.91946866  DT.92042678  DT.100892554  DT.100892552 
    DT.92066176  DT.100892660  DT.121203278  DT.121203045  DT.121203277  DT.95079787  DT.100892562  DT.91739649 
    DT.121203022  DT.100892515  DT.100048108  DT.121203341  DT.95247243  DT.100892525  DT.92060112  DT.121203136 

    24/225 AceView cDNA sequences (see all 225):

    BM787842 T63537 CB129068 AU121622 BP344558 AI128309 AA524467 BQ719762 
    AA714819 BU629998 BQ716868 BP345058 BQ888128 AU106531 BM741186 BQ934245 
    AW513218 BM856788 CB128516 AU121849 AV710042 AA578722 BP345401 CB130133 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBC    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d
    SP1:              -                           
    SP2:              -     -                     
    SP3:                                          


    ECgene alternative splicing isoforms for UBC

    Expression
    for UBC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UBC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Endoderm-like cells (Generation of hepato...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UBC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBC

    SOURCE GeneReport for Unigene cluster: Hs.520348
        SABiosciences Expression via Pathway-Focused PCR Arrays including UBC: 
              Parkinson's Disease in human mouse rat
              Housekeeping Genes PCR Array in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for UBC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBC gene from 8/37 species (see all 37)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UBB1 ubiquitin B 86.55(n)
    100(a)    		   396190  XM_001233376.2  XP_001233377.1 
    lizard
    (Anolis carolinensis)    		 Reptilia UBC6
    		 --
    		 99(a)
    		 1 → many
    		 AAWZ02039315(3668-4813)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC054976.12   -- 82.96(n)    BC054976.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii BC049473.12   -- 87.98(n)    BC049473.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ubi-p63E1 , 3 response to heat protein degradation tagging3
    Ubiquitin-63E1    		 100(a)
    (best of 3)3
    82.29(n)1
    99.71(a)1    		   3 63F53
    384561  NM_168043.21  NP_728908.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea ubq-11 Protein UBQ-1 79.42(n)
    98.25(a)    		   175840  NM_171139.3  NP_741157.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons UBQ81 polyubiquitin 8 70.49(n)
    76.25(a)    		   820137  NM_111814.1  NP_566357.1 
    rice
    (Oryza sativa)    		 Liliopsida AK121590.12   -- 82.36(n)    AK121590.1 


    ENSEMBL Gene Tree for UBC (if available)
    TreeFam Gene Tree for UBC (if available) 

    Paralogs
    for UBC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBC gene
    UBB2  UBD2  ISG152  UBBP42  
    15 SIMAP similar genes for UBC using alignment to 18 protein entries:     UBC_HUMAN (see all proteins):
    UBA52    UBB    DKFZp434K0435    RPS27A    UBBP4    NEDD8
    NEDD8-MDP1    FAU    ZFAND4    PARK2    RAD23A    UBD
    OASLd    ISG15    UBL4A

    UBC for paralogs           About GeneDecksing


    5/8 Pseudogenes.org Pseudogenes for UBC (see all 8)
    PGOHUM00000258675 PGOHUM00000256799 PGOHUM00000244830 PGOHUM00000240380 PGOHUM00000259880


    Genomic Variants
    for UBC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 NCBI SNPs in UBC are shown (see all 214)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1122052081,2
    		C,--125395728(+) CATTCC/TGNNNN 1 -- ds50013Minor allele frequency- T:0.04CSA WA NA 240
    rs1907940641,2
    		--125395749(+) ACCCAA/CAAACC 1 -- ds50010--------
    rs1930728061,2
    		--125395821(+) AACTTA/CTTTTT 1 -- ds50010--------
    rs768019291,2
    		F,--125395826(+) CTTTTT/GTGAGT 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1838974491,2
    		--125395883(+) TGCAAC/TCTCTG 1 -- ds50010--------
    rs1387074191,2
    		--125395892(+) TGCTTC/TGTAGG 1 -- ds50010--------
    rs1428139101,2
    		--125395955(+) TCACTA/GCCACA 1 -- ds50010--------
    rs1881762361,2
    		--125396034(+) CTTTTA/GTTTGC 1 -- ds50010--------
    rs71351511,2
    		C,F,A,H,--125396055(+) TACAGT/GTCATA 1 -- ds500131Minor allele frequency- G:0.46NS EA NA MN WA 3582
    rs760628461,2
    		F,--125396099(+) ACCGTT/GACCAC 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for UBC (125396150 - 125401914 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for UBC
         1 Indel: 24889

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    Disorders / Diseases
    for UBC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UBC for disorders           About GeneDecksing

    OMIM gene information: 191340    OMIM disorders: --

    20/119 diseases for UBC (see all 119):    About MalaCards
    limb-girdle muscular dystrophy type 2h    limb-girdle muscular dystrophy    spinal cord injury    machado-joseph disease
    myoclonus-dystonia    peutz-jeghers syndrome    human t-cell leukemia virus type 1    lewy body dementia
    nijmegen breakage syndrome    spinocerebellar ataxia type 3    adenomatous polyposis coli    myoclonus epilepsy
    progressive myoclonus epilepsy    muscular dystrophy    myoclonus    severe acute respiratory syndrome
    multiple endocrine neoplasia    spinocerebellar ataxia    xeroderma pigmentosum    amyotrophic lateral sclerosis

    2 Novoseek disease relationships for UBC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 42.8 1 2379587 (1)
    tumors 0 1 17510243 (1)

    Human Genome Epidemiology (HuGE) Navigator: UBC (20 documents)

    Export disorders for UBC gene to outside databases

    Publications
    for UBC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBC gene, integrated from 9 sources (see all 2667):
    (articles sorted by number of sources associating them with UBC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. (PubMed id 11872750)1, 3, 9 Marinovic A.C....Price S.R. (2002)
    2. Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PubMed id 14745543)1, 2, 9 Tachikui H.... Inoue I. (2003)
    3. Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product. (PubMed id 9644242)1, 2, 9 Kim N.S.... Kato S. (1998)
    4. Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. (PubMed id 9504932)1, 2, 9 Nenoi M.... Kawano A. (1998)
    5. Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells. (PubMed id 8917096)1, 2, 9 Nenoi M.... Tsuji H. (1996)
    6. Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. (PubMed id 21399617)1, 2 Ye Y....Komander D. (2011)
    7. Lys11-linked ubiquitin chains adopt compact conformat ions and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874)1, 2 Bremm A....Komander D. (2010)
    8. The emerging complexity of protein ubiquitination. (PubMed id 19754430)1, 2 Komander D. (2009)
    9. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PubMed id 18719106)1, 2 Motegi A.... Myung K. (2008)
    10. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (2007)

    External Searches for UBC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UBC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7316 HGNC: 12468 AceView: UBC Ensembl:ENSG00000150991 euGenes: HUgn7316
    ECgene: UBC Kegg: 7316 H-InvDB: UBC

    Other Databases showing UBC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UBC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBC Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for UBC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UBC gene:
    Search GeneIP for patents involving UBC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for UBC gene

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    About This Section

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