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Aliases & Descriptions for UBC
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| HMG20 2 | | UBA80 3 | | UBCEP1 3 | | UBCEP2 3 | | polyubiquitin-C 2 |
| | | Descriptions |
|---|
| ubiquitin C 2 |
|
| | Search outside databases for aliases for UBC genePrevious GC identifers: GC12M124151 GC12M125142 GC12M123749 |
Summaries for UBC(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988Function: Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repairGene Wiki entry for UBC (Ubiquitin_C) |
Genomic Location for UBC
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the UBC gene 
Entrez Gene cytogenetic band: 12q24.3 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.3UBC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M123921:
(about GC identifiers)
Start:
|
123,962,145 bp from pter |
End:
|
123,965,530 bp from pter |
Size:
|
3,386 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009755.18
| Proteins for UBC
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988 (See
protein sequence)Recommended Name: Ubiquitin Size: 76 amino acids; 8565 Da
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a)
PDB structures from and Proteopedia :1C3T (3D)
 1CMX (3D)
 1D3Z (3D)
 1F9J (3D)
 1FXT (3D)
 1G6J (3D)
 1GJZ (3D)
 1NBF (3D)
 1OGW (3D)
 1Q5W (3D)
 1S1Q (3D)
 1SIF (3D)
 1TBE (3D)
 1UBI (3D)
 1UBQ (3D)
 1XD3 (3D)
 1XQQ (3D)
 1YX5 (3D)
 1YX6 (3D)
 1ZGU (3D)
 1ZO6 (3D)
 2AYO (3D)
 2BGF (3D)
 2DEN (3D)
 2FUH (3D)
 2G45 (3D)
 2GBJ (3D)
 2GBK (3D)
 2GBM (3D)
 2GBN (3D)
 2GBR (3D)
 2HTH (3D)
 2IBI (3D)
 2J7Q (3D)
 2JF5 (3D)
 2JRI (3D)
 2JY6 (3D)
 2JZZ (3D)
 2K25 (3D)
 2K6D (3D)
 2K8B (3D)
 2K8C (3D)
 2NR2 (3D)
 2O6V (3D)
 2OJR (3D)
 2PE9 (3D)
 2PEA (3D)
 2W9N (3D)
 2Z59 (3D)
 2ZCB (3D)
 2ZVN (3D)
 2ZVO (3D)
 3BY4 (3D)
 3C0R (3D)
 3DVG (3D)
 3DVN (3D)
 3EEC (3D)
 3EFU (3D)
 3EHV (3D)
 
Secondary accessions: P02248 P02249 P02250 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7Post-translational modifications:
Several types of polymeric chains can be formed, depending on the lysine used for the assembly1
REFSEQ proteins: NP_066289.2
ENSEMBL proteins: ENSP00000344818 ENSP00000365977 ENSP00000376199 ENSP00000365976 ENSP00000365975 ENSP00000376200
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for UBC: Assays for UBC: | Protein
Domains/ Families for UBC(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P62988
ProtoNet protein and cluster: P62988 UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988Similarity: Belongs to the ubiquitin family | Gene Function for UBC
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021009
Applied Biosystems Silencer® siRNAs for UBC
Sigma-Aldrich siRNA and siRNA Panels for UBC  Sigma-Aldrich shRNA Panels and shRNA for UBC  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021009                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021009                                  untagged cDNA clones in CMV expression vector (see all 2): NM_021009 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_021009
UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988Function: Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repairGenatlas biochemistry entry for UBC:poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ubc):
| Pathways & Interactions for UBC
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for UBC (Your Favorite Gene powered by Ingenuity) (see all 9
) 
5/819 Interacting proteins for UBC (P629881, 2 ENSP000003448183) via UniProtKB, MINT, and/or STRING (see all 819
)About this table
|
Drugs & Compounds for UBC(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBC 2 Novoseek chemical compound relationships for UBC gene
About this table
|
Transcripts for UBC(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021009
Sigma-Aldrich siRNA and siRNA Panels for UBC  Sigma-Aldrich shRNA Panels and shRNA for UBC  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_021009 REFSEQ mRNAs for UBC gene: NM_021009.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_021009               OriGene GFP tagged cDNA clone in CMV expression vector: NM_021009                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_021009                                  untagged cDNA clones in CMV expression vector (see all 2): NM_021009  Additional cDNA sequence: AB009010.1 AB209782.1 AF052164.1 AK026846.1 AK056939.1 AK097415.1 AK098827.1 AK129749.1 AK291539.1 AL117514.1 AY732488.1 AY819759.1 BC000449.2 BC008955.2 BC014880.1 BC039193.1 BC080583.1 BC093445.1 CR611585.1 CR615117.1 CR621420.1 M17597.1 24/237 DOTS entries (see all 237
): DT.100892635 DT.100892528 DT.91842147 DT.100892593 DT.92042678 DT.91946866 DT.100892554 DT.100892552 DT.92066176 DT.100892562 DT.100048108 DT.100892660 DT.121203277 DT.121203278 DT.121203022 DT.121203045 DT.95079787 DT.91739649 DT.100892515 DT.121203341 DT.95247243 DT.92060112 DT.121203136 DT.100892525 24/225 AceView cDNA sequences (see all 225
):BQ889973 AA304176 AI128309 BQ676274 AI952618 BM785452 AI708418 AU119238 AU121849 CB132466 AL538959 BQ212856 CB156632 BP344558 CR611585 BQ719557 BX438063 BQ423460 AA316520 BM790305 AA678451 BU150096 BF000943 BP345058
highest scoring ESTs for UBC:AB009010 AK129749 AL535209 AL535583 AL541647 AU076788 AU121100 AU121622 AU122758 AV661858 Unigene Cluster for UBC: Ubiquitin C Hs.520348 [show with all ESTs]Unigene Representative Sequence: AB209782
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for UBC
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBC
6 Ensembl transcripts including schematic representations: ENST00000339647
ENST00000376781
ENST00000392398
ENST00000339545
ENST00000325925
ENST00000392399
|
Expression for UBC
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBC expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBC
1 / 2 / 3 8 probe-sets matching UBC gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.520348
Expression variation in blood from EXPOLDB for UBC |
Orthologs for UBC
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBC gene from 5/26 species (see all 26
)
About this table Species with no ortholog for UBC
ENSEMBL Gene Tree for UBC | Paralogs for UBC(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBC gene
- UBB2 UBA522 ENSG000001892512
|
SNPs/Variants for UBC(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBC (up to first 250kb)
|
Disorders & Mutations for UBC
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 191340
2 Novoseek disease relationships for UBC gene
About this table
|
Medical News for UBC(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for UBC (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/177 PubMed articles for UBC gene (see all 177
):- Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. (PubMed id 11872750)1, 2, 3 Marinovic A.C....Price S.R. (2002)
- Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PubMed id 14745543)1, 3, 4 Tachikui H.... Inoue I. (2003)
- Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. (PubMed id 9504932)1, 3, 4 Nenoi M.... Kawano A. (1998)
- Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product. (PubMed id 9644242)1, 3, 4 Kim N.S.... Kato S. (1998)
- Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells. (PubMed id 8917096)1, 3, 4 Nenoi M.... Tsuji H. (1996)
- Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3. (PubMed id 1315303)2, 3 Board P.G....Webb G.C. (1992)
- Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells. (PubMed id 2820408)3, 4 Einspanier R.... Scheit K.H. (1987)
- The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences. (PubMed id 2988935)3, 4 Wiborg O....Vuust J. (1985)
- The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. (PubMed id 18599482)3 Winborn B.J....Paulson H.L. (2008)
- Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. (PubMed id 18632619)3 Sehat B....Larsson O. (2008)
|
Search for UBC
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBC
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBC
(According to HUGE)
About This Section
| -- |
Specialized Databases showing UBC(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBC(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBC:

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Incremental update: 13 Oct 2009
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