UBC Gene
protein-coding GIFtS : 66
GCID: GC12 M125396
ubiquitin C
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Aliasesfor UBC gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ubiquitin C 1 2 HMG202 Polyubiquitin-C1
Export aliases for UBC gene to outside databases Previous GC identifers: GC12M124151 GC12M125142 GC12M123749 GC12M123921 GC12M122360
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Summariesfor UBC gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for UBC : This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. (provided by RefSeq, Aug 2010) UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48 Function : Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling Gene Wiki entry for UBC (Ubiquitin C)
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Genomic Viewsfor UBC gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009755.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UBC gene promoter: Max1 AP-2alpha isoform 3 Sp1 AP-2alpha isoform 2 AP-2alpha isoform 4 AP-2alpha MRF-2 AP-2alphaA c-Myc Other transcription factors Search SABiosciences Chromatin IP Primers for UBC Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat UBC
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12q24.3 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.3 UBC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M125396: view genomic region
(about GC identifiers )
Start:
125,396,150 bp from pter
End:
125,401,914 bp from pter
Size:
5,765 bases
Orientation:
minus strand
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Proteinsfor UBC gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48 (See
protein sequence )Recommended Name: Polyubiquitin-C precursor Size : 685 amino acids; 77039 Da
Subcellular location : Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)
Miscellaneous : Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitinfused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains
Miscellaneous : For the sake of clarity sequence features are annotated only for the first chain, and are not repeatedfor each of the following chains
6/129 PDB 3D structures from and Proteopedia for UBC (see all 129 ):1C3T (3D)
  1CMX (3D)
  1D3Z (3D)
  1F9J (3D)
  1FXT (3D)
  1G6J (3D)
 
Secondary accessions : P02248 P02249 P02250 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7 Explore the universe of human proteins at neXtProt for UBC: NX_P0CG48 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P0CG48 UBC Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_066289.2 ENSEMBL proteins: ENSP00000441543 ENSP00000442456 ENSP00000443053 ENSP00000445033 ENSP00000445320 ENSP00000344818 ENSP00000442173 ENSP00000440205 ENSP00000442800 ENSP00000445337 ENSP00000439492 ENSP00000438289 ENSP00000441238 ENSP00000437452 ENSP00000441556 ENSP00000438394 Reactome Protein details: P0CG48 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
UBC for ontologies About GeneDecksing UBC Antibody Products: Assay Products for UBC:
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Protein
Domains / Familiesfor UBC gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
UBC for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P0CG48 ProtoNet protein and cluster: P0CG48
UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48 Similarity : Belongs to the ubiquitin familySimilarity : Contains 9 ubiquitin-like domains
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Functionfor UBC gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48 Function : Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling
Genatlas biochemistry entry for UBC : poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBC (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBCOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UBC (NM_021009 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UBC
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBC
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
UBC for ontologies About GeneDecksing 9 GenomeRNAi human phenotypes for UBC :Animal Models: Mouse knock-out Ubc tm11Rrk for UBC 6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ubc) :
UBC for phenotypes About GeneDecksing
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Pathways & Interactionsfor UBC gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/88 super-pathways (see all 88 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ubiquitinated Orc1 is degraded by the proteasome 2 Signal Transduction 3 TRAF6 Mediated Induction of proinflammatory cytokines 4 Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant 5 Signaling by FGFR
Pathway sources See GeneCards unified pathways Show all pathways 5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBC (see all 17 )5/23 GeneGo (Thomson Reuters) Pathways for UBC (see all 23 )2 BioSystems Pathways for UBC 5/242
Reactome Pathways for UBC (see all 242 )1
Kegg Pathway (Kegg details for UBC) :
UBC for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBC STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/7169 Interacting proteins for UBC (P0CG48 2 , 3 ENSP00000344818 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 7169 )About this table Gene Ontology (GO): 5/69 biological process terms (GO ID links to tree view) (see all 69 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000075 cell cycle checkpoint
TAS -- GO:0000080 G1 phase of mitotic cell cycle
TAS -- GO:0000082 G1/S transition of mitotic cell cycle
TAS -- GO:0000084 S phase of mitotic cell cycle
TAS -- GO:0000122 negative regulation of transcription from RNA polymerase II promoter
TAS --
UBC for ontologies About GeneDecksing
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Drugs & Compoundsfor UBC gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
UBC for compounds About GeneDecksing Browse Tocris compounds for UBC 1 DrugBank Compound for UBC About this table 3 Novoseek chemical compound relationships for UBC gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
finrozole
90.5
1
14982857 (1)
porphobilinogen
52.2
1
16458257 (1)
dexamethasone
0
4
11872750 (3), 16954342 (1)
Search CenterWatch for drugs/clinical trials and news about UBC
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Transcriptsfor UBC gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for UBC gene: NM_021009.5 Unigene Cluster for UBC:
Ubiquitin C Hs.520348 [show with all ESTs ] Unigene Representative Sequence: AB209782 18 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000536769 (uc021rge.1 ) ENST00000535460 (uc001ugu.1 ) ENST00000538617 ENST00000536834 ENST00000541046 ENST00000339647 (uc001ugs.4 uc001ugt.3 uc001ugv.3 uc001ugw.3 )ENST00000544656 ENST00000541272 ENST00000540351 (uc009zyf.1 ) ENST00000541645 ENST00000535131 ENST00000544481 ENST00000546271 ENST00000540700 ENST00000535859 ENST00000536661 ENST00000542416 ENST00000546120 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBC (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBCOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UBC (NM_021009 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UBC
Additional cDNA sequence: AB009010.1 AB209782.1 AF052164.1 AK026846.1 AK056939.1 AK097415.1 AK098827.1 AK129749.1 AK291539.1 AL117514.1 AY732488.1 AY819759.1 BC000449.2 BC008955.2 BC014880.1 BC039193.1 BC080583.1 BC093445.1 M17597.1
24/204 DOTS entries (see all 204 ): DT.100892635 DT.100892528
DT.91842147 DT.100892593 DT.91946866 DT.92042678 DT.100892554 DT.100892552 DT.92066176 DT.100892660 DT.121203278 DT.121203045 DT.121203277 DT.95079787 DT.100892562 DT.91739649 DT.121203022 DT.100892515 DT.100048108 DT.121203341 DT.95247243 DT.100892525 DT.92060112 DT.121203136 24/225 AceView cDNA sequences (see all 225 ):
BM787842 T63537 CB129068 AU121622 BP344558 AI128309 AA524467 BQ719762 AA714819 BU629998 BQ716868 BP345058 BQ888128 AU106531 BM741186 BQ934245 AW513218 BM856788 CB128516 AU121849 AV710042 AA578722 BP345401 CB130133 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for UBC About this scheme ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d SP1 :     -           SP2 :     -   -         SP3 :              
ECgene alternative splicing isoforms for UBC
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Expression for UBC gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section UBC expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image UBC expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Endoderm-like cells (Generation of hepato... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See UBC Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UBC SOURCE GeneReport for Unigene cluster: Hs.520348 SABiosciences Expression via Pathway-Focused PCR Arrays including UBC : Parkinson's Disease in human mouse rat Housekeeping Genes PCR Array in human mouse rat Nitric Oxide Signaling Pathway in human mouse rat Ubiquitin Ligases in human mouse rat
Primer Products: Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat UBC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat UBC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat UBC In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBC
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Orthologsfor UBC gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBC gene from 8/37 species (see all 37 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
UBB1
ubiquitin B
86.55(n) 100(a)
 
396190 XM_001233376.2 XP_001233377.1
lizard (Anolis carolinensis)
Reptilia
UBC6
--
99(a)
1 → many
AAWZ02039315(3668-4813)
African clawed frog (Xenopus laevis)
Amphibia
BC054976.12
--
82.96(n)
 
BC054976.1
zebrafish (Danio rerio)
Actinopterygii
BC049473.12
--
87.98(n)
 
BC049473.1
fruit fly (Drosophila melanogaster)
Insecta
Ubi-p63E1 , 3
response to heat protein degradation tagging3 Ubiquitin-63E1
100(a) (best of 3)3 82.29(n) 1 99.71(a) 1
 
3 63F53 38456 1 NM_168043.2 1 NP_728908.1 1
worm (Caenorhabditis elegans)
Secernentea
ubq-11
Protein UBQ-1
79.42(n) 98.25(a)
 
175840 NM_171139.3 NP_741157.1
thale cress (Arabidopsis thaliana)
eudicotyledons
UBQ81
polyubiquitin 8
70.49(n) 76.25(a)
 
820137 NM_111814.1 NP_566357.1
rice (Oryza sativa)
Liliopsida
AK121590.12
--
82.36(n)
 
AK121590.1
ENSEMBL Gene Tree for UBC (if available)TreeFam Gene Tree for UBC (if available)
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Paralogsfor UBC gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for UBC gene UBB 2 UBD 2 ISG15 2 UBBP4 2 15 SIMAP similar genes for UBC using alignment to 18 protein entries: UBC_HUMAN (see all proteins ):UBA52 UBB DKFZp434K0435 RPS27A UBBP4 NEDD8 NEDD8-MDP1 FAU ZFAND4 PARK2 RAD23A UBD OASLd ISG15 UBL4A
UBC for paralogs About GeneDecksing 5/8 Pseudogenes.org Pseudogenes for UBC (see all 8 )PGOHUM00000258675 PGOHUM00000256799 PGOHUM00000244830 PGOHUM00000240380 PGOHUM00000259880
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Genomic Variantsfor UBC gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for UBC (125396150 - 125401914 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for UBC 1 Indel : 24889
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing UBC
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Disorders
/ Diseasesfor UBC gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
UBC for disorders About GeneDecksing
OMIM gene information: 191340
OMIM disorders : --20/119 diseases for UBC (see all 119 ): About MalaCards limb-girdle muscular dystrophy type 2h limb-girdle muscular dystrophy spinal cord injury machado-joseph disease myoclonus-dystonia peutz-jeghers syndrome human t-cell leukemia virus type 1 lewy body dementia nijmegen breakage syndrome spinocerebellar ataxia type 3 adenomatous polyposis coli myoclonus epilepsy progressive myoclonus epilepsy muscular dystrophy myoclonus severe acute respiratory syndrome multiple endocrine neoplasia spinocerebellar ataxia xeroderma pigmentosum amyotrophic lateral sclerosis 2 Novoseek disease relationships for UBC gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
mammary tumor
42.8
1
2379587 (1)
tumors
0
1
17510243 (1)
Human Genome Epidemiology (HuGE) Navigator: UBC (20 documents) Export disorders for UBC gene to outside databases
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Publicationsfor UBC gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for UBC gene, integrated from 9 sources (see all 2667 ): (articles sorted by number of sources associating them with UBC) Utopia : connect your pdf to the dynamic world of online information
Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. (PubMed id 11872750) 1 , 3, 9 Marinovic A.C....Price S.R. (2002) Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PubMed id 14745543) 1 , 2 , 9 Tachikui H.... Inoue I. (2003) Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product. (PubMed id 9644242) 1 , 2 , 9 Kim N.S.... Kato S. (1998) Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. (PubMed id 9504932) 1 , 2 , 9 Nenoi M.... Kawano A. (1998) Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells. (PubMed id 8917096) 1 , 2 , 9 Nenoi M.... Tsuji H. (1996) Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. (PubMed id 21399617) 1 , 2 Ye Y....Komander D. (2011) Lys11-linked ubiquitin chains adopt compact conformat ions and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874) 1 , 2 Bremm A....Komander D. (2010) The emerging complexity of protein ubiquitination. (PubMed id 19754430) 1 , 2 Komander D. (2009) Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PubMed id 18719106) 1 , 2 Motegi A.... Myung K. (2008) The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973) 1 , 2 Vasilescu J.... Figeys D. (2007)
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External Searches for UBC gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing UBC gene
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
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Other Databases showing UBC gene
(According to HUGE )
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Specialized Databases showing UBC gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for UBC gene: Search GeneIP for patents involving UBC GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor UBC gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for UBC OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for UBC Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for UBC OriGene 3'-UTR Clone for UBC OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBC OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBC Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for UBC OriGene Custom Protein Services for UBC OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat UBC QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing UBC QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat UBC QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat UBC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat UBC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat UBC
Search Tocris compounds for UBC
UBC Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBC
ThermoFisher Antibodies for UBC
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UBC
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