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Aliases for UBC Gene

Aliases for UBC Gene

  • Ubiquitin C 2 3
  • Polyubiquitin-C 2 3
  • HMG20 3

External Ids for UBC Gene

Previous GeneCards Identifiers for UBC Gene

  • GC12M124151
  • GC12M125142
  • GC12M123749
  • GC12M123921
  • GC12M125396
  • GC12M122360

Summaries for UBC Gene

Entrez Gene Summary for UBC Gene

  • This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

GeneCards Summary for UBC Gene

UBC (Ubiquitin C) is a Protein Coding gene. Diseases associated with UBC include tuberous sclerosis-1 and mulibrey nanism. Among its related pathways are PI-3K cascade and Signaling by FGFR. GO annotations related to this gene include protease binding. An important paralog of this gene is UBB.

UniProtKB/Swiss-Prot for UBC Gene

  • Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene Wiki entry for UBC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBC Gene

Genomics for UBC Gene

Genomic Location for UBC Gene

Start:
124,911,604 bp from pter
End:
124,917,368 bp from pter
Size:
5,765 bases
Orientation:
Minus strand

Genomic View for UBC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBC Gene

Proteins for UBC Gene

  • Protein details for UBC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG48-UBC_HUMAN
    Recommended name:
    Polyubiquitin-C
    Protein Accession:
    P0CG48
    Secondary Accessions:
    • P02248
    • P02249
    • P02250
    • P62988
    • Q29120
    • Q6LBL4
    • Q6LDU5
    • Q8WYN8
    • Q91887
    • Q91888
    • Q9BWD6
    • Q9BX98
    • Q9UEF2
    • Q9UEG1
    • Q9UEK8
    • Q9UPK7

    Protein attributes for UBC Gene

    Size:
    685 amino acids
    Molecular mass:
    77039 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains
    • Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains

    Three dimensional structures from OCA and Proteopedia for UBC Gene

neXtProt entry for UBC Gene

Proteomics data for UBC Gene at MOPED

Post-translational modifications for UBC Gene

  • Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PARK2), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
  • Ubiquitination at Lys6, Lys11, Lys27, Lys29, Lys33, Lys48, and Lys63
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UBC Gene

Domains for UBC Gene

Protein Domains for UBC Gene

Graphical View of Domain Structure for InterPro Entry

P0CG48

UniProtKB/Swiss-Prot:

UBC_HUMAN :
  • P0CG48
Domain:
  • Contains 9 ubiquitin-like domains.
Family:
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with UBC: view

No data available for Gene Families for UBC Gene

Function for UBC Gene

Molecular function for UBC Gene

GENATLAS Biochemistry: poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit
UniProtKB/Swiss-Prot Function: Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene Ontology (GO) - Molecular Function for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21185309
GO:0005515 protein binding IPI 16256071
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with UBC: view
genes like me logo Genes that share phenotypes with UBC: view

Animal Models for UBC Gene

MGI Knock Outs for UBC:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for UBC Gene

Localization for UBC Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBC Gene

Ubiquitin: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBC Gene COMPARTMENTS Subcellular localization image for UBC gene
Compartment Confidence
cytosol 4
endosome 4
nucleus 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0010008 endosome membrane TAS --
genes like me logo Genes that share ontologies with UBC: view

Pathways for UBC Gene

SuperPathways for UBC Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
.38
2 Loss of Function of SMAD2/3 in Cancer
3 Signaling by NOTCH1 PEST Domain Mutants in Cancer
4 Signaling by FGFR
5 p75 NTR receptor-mediated signalling
genes like me logo Genes that share pathways with UBC: view

Gene Ontology (GO) - Biological Process for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000209 protein polyubiquitination TAS --
genes like me logo Genes that share ontologies with UBC: view

Compounds for UBC Gene

(1) Drugbank Compounds for UBC Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
N-Formylmethionine
target

(3) Novoseek inferred chemical compound relationships for UBC Gene

Compound -log(P) Hits PubMed IDs
finrozole 90.5 1
porphobilinogen 52.2 1
dexamethasone 0 4
genes like me logo Genes that share compounds with UBC: view

Transcripts for UBC Gene

Unigene Clusters for UBC Gene

Ubiquitin C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3:

Relevant External Links for UBC Gene

GeneLoc Exon Structure for
UBC
ECgene alternative splicing isoforms for
UBC

Expression for UBC Gene

mRNA expression in normal human tissues for UBC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBC Gene

This gene is overexpressed in Muscle - Skeletal (4.6) and Whole Blood (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for UBC Gene

SOURCE GeneReport for Unigene cluster for UBC Gene Hs.520348

genes like me logo Genes that share expressions with UBC: view

No data available for mRNA Expression by UniProt/SwissProt for UBC Gene

Orthologs for UBC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBB 36
  • 99 (a)
ManyToMany
UBC 35
  • 94.01 (n)
  • 99.85 (a)
cow
(Bos Taurus)
Mammalia UBC 35
  • 90.75 (n)
  • 99.56 (a)
UBC 36
  • 74 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia UBC 35
  • 89.76 (n)
  • 100 (a)
mouse
(Mus musculus)
Mammalia Ubc 35
  • 89.83 (n)
  • 99.71 (a)
Ubc 16
Ubc 36
  • 62 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 100 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ubc 35
  • 88.71 (n)
  • 99.71 (a)
chicken
(Gallus gallus)
Aves UBB 36
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7640 35
ubb 35
  • 85.67 (n)
  • 98.39 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8042 35
zebrafish
(Danio rerio)
Actinopterygii UBC 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11700 36
  • 89 (a)
OneToMany
Ubi-p63E 35
  • 82.29 (n)
  • 99.71 (a)
CG18282 37
  • 97 (a)
CG11700 37
  • 90 (a)
Ubi-p63E 37
  • 100 (a)
worm
(Caenorhabditis elegans)
Secernentea ubq-1 36
  • 71 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPL40A 36
  • 70 (a)
ManyToMany
RPL40B 36
  • 70 (a)
ManyToMany
UBI4 38
soybean
(Glycine max)
eudicotyledons Gma.7789 35
thale cress
(Arabidopsis thaliana)
eudicotyledons UBQ8 35
  • 70.6 (n)
  • 76.25 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.28374 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
ManyToMany
Species with no ortholog for UBC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UBC Gene

ENSEMBL:
Gene Tree for UBC (if available)
TreeFam:
Gene Tree for UBC (if available)

Paralogs for UBC Gene

Paralogs for UBC Gene

genes like me logo Genes that share paralogs with UBC: view

Variants for UBC Gene

Sequence variations from dbSNP and Humsavar for UBC Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs6657 -- 124,911,957(-) CGTCT(C/T)AGAGG reference, synonymous-codon
rs7959 -- 124,911,891(-) GAGCC(C/G)AGTGA reference, synonymous-codon
rs8023 -- 124,911,852(+) TCCTT(A/G)TCTTG synonymous-codon, reference
rs8963 -- 124,912,818(-) ATCAC(C/T)CTCGA synonymous-codon, reference
rs14564 -- 124,911,821(+) GATCA(A/G)CCTCT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for UBC Gene

Variant ID Type Subtype PubMed ID
esv1696538 CNV Deletion 17803354

Relevant External Links for UBC Gene

HapMap Linkage Disequilibrium report
UBC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBC Gene

Disorders for UBC Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for UBC Gene including...

Search for UBC Gene in MalaCards »

(1) University of Copenhagen DISEASES for UBC Gene

(2) Novoseek inferred disease relationships for UBC Gene

Disease -log(P) Hits PubMed IDs
mammary tumor 42.8 1
tumors 0 1

Relevant External Links for UBC

Genetic Association Database (GAD)
UBC
Human Genome Epidemiology (HuGE) Navigator
UBC
genes like me logo Genes that share disorders with UBC: view

No data available for UniProtKB/Swiss-Prot for UBC Gene

Publications for UBC Gene

  1. Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. (PMID: 9504932) Nenoi M. … Kawano A. (Genetics 1998) 3 4 23
  2. Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product. (PMID: 9644242) Kim N.S. … Kato S. (J. Biochem. 1998) 3 4 23
  3. Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. (PMID: 11872750) Marinovic A.C. … Price S.R. (J. Biol. Chem. 2002) 2 3 23
  4. Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PMID: 14745543) Tachikui H. … Inoue I. (J. Mol. Evol. 2003) 3 4 23
  5. Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells. (PMID: 8917096) Nenoi M. … Tsuji H. (Gene 1996) 3 4 23

Products for UBC Gene

Sources for UBC Gene

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