Aliases for UBC Gene
External Ids for UBC Gene
- HGNC: 12468
- Entrez Gene: 7316
- Ensembl: ENSG00000150991
- OMIM: 191340
- UniProtKB: P0CG48
Previous GeneCards Identifiers for UBC Gene
- GC12M124151
- GC12M125142
- GC12M123749
- GC12M123921
- GC12M125396
- GC12M122360
Summaries for UBC Gene
-
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]
GeneCards Summary for UBC Gene
UBC (Ubiquitin C) is a Protein Coding gene. Diseases associated with UBC include Apocrine Adenoma and Congenital Granular Cell Tumor. Among its related pathways are HIV Life Cycle and DNA Double-Strand Break Repair. GO annotations related to this gene include poly(A) RNA binding and protease binding. An important paralog of this gene is UBB.
UniProtKB/Swiss-Prot for UBC Gene
-
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBC Gene
Genomics for UBC Gene
Regulatory Elements for UBC Gene
Enhancers for UBC Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around UBC on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the UBC gene promoter:
Regulatory Element Products
Genomic Location for UBC Gene
- Chromosome:
- 12
- Start:
- 124,911,604 bp from pter
- End:
- 124,917,368 bp from pter
- Size:
- 5,765 bases
- Orientation:
- Minus strand
Genomic View for UBC Gene
Genes around UBC on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.31 by Ensembl
- 12q24.31 by Entrez Gene
- 12q24.3 by HGNC
UBC Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for UBC Gene
Proteins for UBC Gene
-
Protein details for UBC Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P0CG48-UBC_HUMAN
- Recommended name:
- Polyubiquitin-C
- Protein Accession:
- P0CG48
- P02248
- P02249
- P02250
- P62988
- Q29120
- Q6LBL4
- Q6LDU5
- Q8WYN8
- Q91887
- Q91888
- Q9BWD6
- Q9BX98
- Q9UEF2
- Q9UEG1
- Q9UEK8
- Q9UPK7
Protein attributes for UBC Gene
- Size:
- 685 amino acids
- Molecular mass:
- 77039 Da
- Quaternary structure:
- No Data Available
- Miscellaneous:
-
- For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
- Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.
Protein Expression for UBC Gene
Post-translational modifications for UBC Gene
- Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PARK2), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
- Ubiquitination at Lys6, posLast=1111, Lys27, Lys29, posLast=3333, isoforms=48, and isoforms=163
- Modification sites at PhosphoSitePlus
Other Protein References for UBC Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for UBC
- Cell Signaling Technology (CST) Antibodies for UBC (UBC)
- Novus Biologicals Antibodies for UBC
- Invitrogen Antibodies for UBC
- antibodies-online Antibodies for UBC: See all 14
- GeneTex UBC antibody for UBC
Protein Products
- Enzo Life Sciences proteins for UBC
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for UBC
- Origene Custom Protein Services for UBC
- Novus Biologicals proteins for UBC
- ProSpec Recombinant Proteins for UBC
- antibodies-online Proteins for UBC: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for UBC
No data available for DME Specific Peptides for UBC Gene
Domains & Families for UBC Gene
Protein Domains for UBC Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for UBC Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P0CG48- Family:
-
- Belongs to the ubiquitin family.
No data available for Gene Families for UBC Gene
Function for UBC Gene
Molecular function for UBC Gene
- GENATLAS Biochemistry:
- poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit
- UniProtKB/Swiss-Prot Function:
- Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002020 | protease binding | IPI | 21185309 |
| GO:0003723 | RNA binding | IDA | 22681889 |
| GO:0005515 | protein binding | IPI | 8702753 |
Phenotypes for UBC Gene
- MGI mutant phenotypes for UBC:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for UBC:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Synthetic lethal with Ras
- Decreased NF-kappaB reporter expression
- FOXO1 nuclear localization
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- G0/1 arrest
- Increased number of mitotic cells
- Increased cell number in S
- Increased cell death HMECs cells
- Synthetic lethal with vaccinia virus (VACV) infection
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased cell number
- Decreased homologous recombination repair frequency
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased shRNA abundance (Z-score < -2)
- Decreased viability of wild-type and TP53 knockout cells
- Multipolar spindles
- Increased Sindbis virus (SINV) infection
- Decreased viability with paclitaxel
- Inhibition of centrosomal clustering
- HIV Rev nuclear localization
Animal Models for UBC Gene
- MGI Knock Outs for UBC:
-
- Ubc tm1Rrk
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for UBC
-
-
ViGene Biosciences lentiviral particle packaged cDNA for UBC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for UBC gene
- Search ViGene Biosciences for UBC
CRISPR Products
-
OriGene CRISPR knockouts for UBC
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBC
- GenScript: Design CRISPR guide RNA sequences for UBC
miRNA for UBC Gene
- miRTarBase miRNAs that target UBC
-
- hsa-mir-24-3p (MIRT030628)
- hsa-mir-877-5p (MIRT037302)
- hsa-mir-296-3p (MIRT038409)
- hsa-mir-769-3p (MIRT039075)
- hsa-mir-615-3p (MIRT039711)
- hsa-mir-324-3p (MIRT042909)
- hsa-mir-221-3p (MIRT046896)
- hsa-mir-18a-5p (MIRT050710)
- hsa-mir-20a-5p (MIRT439366)
- hsa-mir-106b-5p (MIRT439367)
- hsa-mir-519d-3p (MIRT726199)
- hsa-mir-20b-5p (MIRT726200)
- hsa-mir-93-5p (MIRT726201)
- hsa-mir-17-5p (MIRT726202)
miRNA Products
- Search ViGene Biosciences for UBC
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for UBC
- Browse OriGene Inhibitory RNA Products For UBC
-
ViGene Biosciences ready-to-package AAV shRNAs for UBC gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for UBC
- VectorBuilder custom plasmid, inducible vectors for UBC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UBC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for UBC gene
-
ViGene Biosciences lentiviral particle packaged cDNA for UBC gene
-
ViGene Biosciences ready-to-package AAV shRNAs for UBC gene
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10203 VA4-11236 VA6-10503) for UBC
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBC Gene
Localization for UBC Gene
Subcellular locations from UniProtKB/Swiss-Prot for UBC Gene
- Ubiquitin: Cytoplasm. Nucleus.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 4 |
| endosome | 4 |
| endoplasmic reticulum | 2 |
| cytoskeleton | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005615 | extracellular space | IDA | 16502470 |
| GO:0005634 | nucleus | IDA,IEA | 21630459 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005741 | mitochondrial outer membrane | TAS | -- |
Pathways & Interactions for UBC Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | CDK-mediated phosphorylation and removal of Cdc6 |
.93
.93
|
.80
.78
.70
.47
.31
|
| 2 | RET signaling |
.92
|
.92
|
| 3 | Activated TLR4 signalling | ||
| 4 | HIV Life Cycle |
.92
.65
|
.45
|
| 5 | Signaling by NOTCH1 | ||
Pathways by source for UBC Gene
3 BioSystems pathways for UBC Gene
328 Reactome pathways for UBC Gene
1 KEGG pathway for UBC Gene
23 GeneGo (Thomson Reuters) pathways for UBC Gene
17 Qiagen pathways for UBC Gene
Interacting Proteins for UBC Gene
Selected Interacting proteins:
P0CG48-UBC_HUMAN
ENSP00000344818
for UBC Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | TAS | -- |
| GO:0000165 | MAPK cascade | TAS | -- |
| GO:0000187 | activation of MAPK activity | TAS | -- |
| GO:0000209 | protein polyubiquitination | TAS | -- |
No data available for SIGNOR curated interactions for UBC Gene
Drugs & Compounds for UBC Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| N-Formylmethionine | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for UBC Gene
mRNA/cDNA for UBC Gene
- (1) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (225) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for UBC
-
Santa Cruz Biotechnology (SCBT) CRISPR for UBC
- GenScript: Design CRISPR guide RNA sequences for UBC
miRNA Products
- Search ViGene Biosciences for UBC
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for UBC
- Browse OriGene Inhibitory RNA Products For UBC
-
ViGene Biosciences ready-to-package AAV shRNAs for UBC gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for UBC
- VectorBuilder custom plasmid, inducible vectors for UBC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UBC
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
- eBioscience FlowRNA Probe Sets (VA1-10203 VA4-11236 VA6-10503) for UBC
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | - | |||||||||||
| SP3: |
Expression for UBC Gene
mRNA differential expression in normal tissues according to GTEx for UBC Gene
This gene is overexpressed in Muscle - Skeletal (x4.6) and Whole Blood (x4.4).
This gene is overexpressed in Heart (29.0), Brain (21.2), and Skin (14.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBC Gene
NURSA nuclear receptor signaling pathways regulating expression of UBC Gene:
UBCSOURCE GeneReport for Unigene cluster for UBC Gene:
Hs.520348Evidence on tissue expression from TISSUES for UBC Gene
- Kidney(5)
- Liver(5)
- Lung(5)
- Nervous system(5)
- Blood(4.9)
- Intestine(4.9)
- Skin(4.9)
- Spleen(4.9)
- Heart(4.8)
- Pancreas(4.6)
- Stomach(4.6)
- Eye(4.3)
- Muscle(4.3)
- Thyroid gland(3.9)
- Bone(3.5)
- Bone marrow(3.2)
- Adrenal gland(3)
- Lymph node(3)
- Gall bladder(2.8)
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBC Gene
Orthologs for UBC Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
ManyToMany | |
| chimpanzee (Pan troglodytes) |
Mammalia | UBB 35 |
|
ManyToMany | |
| UBC 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | UBC 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Ubc 34 16 35 |
|
||
| dog (Canis familiaris) |
Mammalia | UBC 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ubc 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | UBB 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ubb 34 |
|
||
| Str.7640 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | UBC 35 |
|
OneToMany | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8042 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG18282 36 |
|
|
|
| CG11700 36 35 |
|
||||
| Ubi-p63E 36 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | ubq-1 35 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RPL40A 35 |
|
ManyToMany | |
| RPL40B 35 |
|
ManyToMany | |||
| UBI4 37 |
|
|
|||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | UBQ8 34 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.7789 34 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.28374 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany |
- Species where no ortholog for UBC was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for UBC Gene
(15) SIMAP similar genes for UBC Gene using alignment to 15 proteins:
Pseudogenes.org Pseudogenes for UBC Gene
Variants for UBC Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000208526 | -- | 124,911,661(+) | AACAA(C/T)TTTAT | utr-variant-3-prime | |
| rs1000263784 | -- | 124,916,004(+) | TCTAC(C/G/T)CTTAA | downstream-variant-500B, upstream-variant-2KB | |
| rs1000340405 | -- | 124,915,676(+) | GTGCA(A/G)GGTAG | downstream-variant-500B, upstream-variant-2KB | |
| rs1000601663 | -- | 124,911,575(+) | TAGAC(C/T)GAAAA | downstream-variant-500B | |
| rs1001268579 | -- | 124,915,001(+) | AGCGG(C/G)TGGGC | upstream-variant-2KB, utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1696538 | CNV | deletion | 17803354 |
| nsv560595 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
12.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.31;
6.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for UBC Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- UBC
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBC Gene
Disorders for UBC Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| apocrine adenoma |
|
|
| congenital granular cell tumor |
|
|
| cystic fibrosis |
|
|
| endometrial small cell carcinoma |
|
|
| splenic artery aneurysm |
|
|
Search UBC in MalaCards
View complete list of genes associated with diseases
Relevant External Links for UBC
No data available for UniProtKB/Swiss-Prot and Genatlas for UBC Gene
Publications for UBC Gene
- Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PMID: 14745543) Tachikui H. … Inoue I. (J. Mol. Evol. 2003) 3 4 22 64
- Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. (PMID: 11872750) Marinovic A.C. … Price S.R. (J. Biol. Chem. 2002) 2 3 22 64
- Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. (PMID: 9504932) Nenoi M. … Kawano A. (Genetics 1998) 3 4 22 64
- Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product. (PMID: 9644242) Kim N.S. … Kato S. (J. Biochem. 1998) 3 4 22 64
- Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells. (PMID: 8917096) Nenoi M. … Tsuji H. (Gene 1996) 3 4 22 64
Products for UBC Gene
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- Enzo Life Sciences proteins for UBC
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- Novus Biologicals Antibodies for UBC
- Novus Biologicals proteins for UBC
- Novus Biologicals
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- ProSpec Recombinant Proteins for UBC
- Addgene plasmids for UBC
- antibodies-online Antibodies for UBC: See all 14
- antibodies-online Kits for UBC: See all 2
- antibodies-online Proteins for UBC: See all 6
- Search antibodies-online for peptides
- GeneTex UBC antibody for UBC
- Search GeneTex for Proteins for UBC
- ViGene Biosciences adenoviral particle packaged cDNA for UBC gene
- ViGene Biosciences lentiviral particle packaged cDNA for UBC gene
- ViGene Biosciences ready-to-package AAV shRNAs for UBC gene
- Search ViGene Biosciences for UBC
- Cyagen custom Knockout/knockin (KOKI) mouse models for UBC
- VectorBuilder custom plasmid, inducible vectors for UBC
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for UBC
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for UBC Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer