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UBC Gene

protein-coding GIFtS: 63

GC12M123921

ubiquitin C
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HMG20 ^²
UBA80 ^³
UBCEP1 ^³
UBCEP2 ^³
polyubiquitin-C ^²

Descriptions
ubiquitin C ^²

External Ids
HGNC: 12468¹
Entrez Gene: 7316²
UniProtKB: P62988³
Ensembl: ENSG00000150991⁷

Search outside databases for aliases for UBC gene

Previous GC identifers: GC12M124151 GC12M125142 GC12M123749

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988

Function: Protein modifier which can be covalently attached to target lysines either as a monomer

or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to

their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked

polymer does not lead to proteasomal degradation and may be required for numerous functions,

including maintenance of chromatin structure, regulation of gene expression, stress response,

ribosome biogenesis and DNA repair

Gene Wiki entry for UBC (Ubiquitin_C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBC gene

Entrez Gene cytogenetic band: 12q24.3 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.3

UBC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M123921: (about GC identifiers)

Start:	123,962,145 bp from pter
End:	123,965,530 bp from pter
Size:	3,386 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_009755.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988 (See protein sequence)

Recommended Name: Ubiquitin

Size: 76 amino acids; 8565 Da

Subcellular location: Cytoplasm. Nucleus

Miscellaneous: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail

repeats, the number of repeats differ between species and strains. In some species there is a

final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single

copy of ubiquitin fused to a ribosomal protein (either L40 or S27a)

PDB structures from and Proteopedia :

1C3T (3D)

1CMX (3D)

1D3Z (3D)

1F9J (3D)

1FXT (3D)

1G6J (3D)

1GJZ (3D)

1NBF (3D)

1OGW (3D)

1Q5W (3D)

1S1Q (3D)

1SIF (3D)

1TBE (3D)

1UBI (3D)

1UBQ (3D)

1XD3 (3D)

1XQQ (3D)

1YX5 (3D)

1YX6 (3D)

1ZGU (3D)

1ZO6 (3D)

2AYO (3D)

2BGF (3D)

2DEN (3D)

2FUH (3D)

2G45 (3D)

2GBJ (3D)

2GBK (3D)

2GBM (3D)

2GBN (3D)

2GBR (3D)

2HTH (3D)

2IBI (3D)

2J7Q (3D)

2JF5 (3D)

2JRI (3D)

2JY6 (3D)

2JZZ (3D)

2K25 (3D)

2K6D (3D)

2K8B (3D)

2K8C (3D)

2NR2 (3D)

2O6V (3D)

2OJR (3D)

2PE9 (3D)

2PEA (3D)

2W9N (3D)

2Z59 (3D)

2ZCB (3D)

2ZVN (3D)

2ZVO (3D)

3BY4 (3D)

3C0R (3D)

3DVG (3D)

3DVN (3D)

3EEC (3D)

3EFU (3D)

3EHV (3D)

Secondary accessions: P02248 P02249 P02250 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6 Q9BX98

Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Post-translational modifications:

Several types of polymeric chains can be formed, depending on the lysine used for the assembly¹

REFSEQ proteins: NP_066289.2

ENSEMBL proteins:

ENSP00000344818 ENSP00000365977 ENSP00000376199 ENSP00000365976 ENSP00000365975 ENSP00000376200

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBC Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for UBC
	Recombinant Proteins from Abcam (Ubiquitin +1, Ubiquitin)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for UBC:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of UBC
	Sigma-Aldrich Antibody Arrays and Antibodies for UBC
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ubiquitin +1, Ubiquitin), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for UBC

Assays for UBC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P62988

ProtoNet protein and cluster: P62988

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988

Similarity: Belongs to the ubiquitin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBC)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021009

Applied Biosystems Silencer® siRNAs for UBC

Sigma-Aldrich siRNA and siRNA Panels for UBC

Sigma-Aldrich shRNA Panels and shRNA for UBC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021009
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021009
untagged cDNA clones in CMV expression vector (see all 2): NM_021009

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021009

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988

Function: Protein modifier which can be covalently attached to target lysines either as a monomer

or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to

their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked

polymer does not lead to proteasomal degradation and may be required for numerous functions,

including maintenance of chromatin structure, regulation of gene expression, stress response,

ribosome biogenesis and DNA repair

Genatlas biochemistry entry for UBC:

poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit

6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ubc):

cellular	embryogenesis	growth/size	hematopoietic system	lethality-prenatal/perinatal
liver/biliary system

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for UBC (Your Favorite Gene powered by Ingenuity) (see all 9 )

TGF-&beta
GABA Receptor Signaling
Hypoxia Signaling in the Cardiovascular System
Renal Cell Carcinoma Signaling
Huntington's Disease Signaling

GeneDecks UBC for the pathways selected above

About GeneDecksing

5/819 Interacting proteins for UBC (P62988^{1, 2} ENSP00000344818³) via UniProtKB, MINT, and/or STRING (see all 819 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HGS	O14964², ENSP00000331201³	MINT-50269 MINT-50283 MINT-50270 MINT-19113 MINT-50265 MINT-49691 MINT-50292 MINT-50106 MINT-50293 MINT-50284 STRING (score=.999)
ATXN3	P54252², ENSP00000352872³	MINT-7012524 MINT-50295 MINT-7012535 MINT-50268 MINT-50267 STRING (score=.998)
STAM	Q92783², ENSP00000366746³	MINT-50276 MINT-50275 MINT-50282 MINT-50277 MINT-6804185 STRING (score=.998)
MALT1	Q9UDY8², ENSP00000319279³	MINT-6177655 MINT-6177702 MINT-6177541 MINT-6177742 MINT-6177677 STRING (score=.969)
IKBKG	Q9Y6K9², ENSP00000358622³	MINT-4787758 MINT-2844364 MINT-4787643 MINT-48219 STRING (score=.999)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBC
2 Novoseek chemical compound relationships for UBC gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
finrozole	91.15	1	14982857 (1)
porphobilinogen	54.22	1	16458257 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBC)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021009

Sigma-Aldrich siRNA and siRNA Panels for UBC

Sigma-Aldrich shRNA Panels and shRNA for UBC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021009

REFSEQ mRNAs for UBC gene:

NM_021009.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021009

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021009
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021009
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_021009

Additional cDNA sequence:

AB009010.1 AB209782.1 AF052164.1 AK026846.1 AK056939.1 AK097415.1 AK098827.1 AK129749.1

AK291539.1 AL117514.1 AY732488.1 AY819759.1 BC000449.2 BC008955.2 BC014880.1 BC039193.1

BC080583.1 BC093445.1 CR611585.1 CR615117.1 CR621420.1 M17597.1

24/237 DOTS entries (see all 237 ):

DT.100892635 DT.100892528 DT.91842147 DT.100892593 DT.92042678 DT.91946866 DT.100892554 DT.100892552

DT.92066176 DT.100892562 DT.100048108 DT.100892660 DT.121203277 DT.121203278 DT.121203022 DT.121203045

DT.95079787 DT.91739649 DT.100892515 DT.121203341 DT.95247243 DT.92060112 DT.121203136 DT.100892525

24/225 AceView cDNA sequences (see all 225 ):

BQ889973 AA304176 AI128309 BQ676274 AI952618 BM785452 AI708418 AU119238

AU121849 CB132466 AL538959 BQ212856 CB156632 BP344558 CR611585 BQ719557

BX438063 BQ423460 AA316520 BM790305 AA678451 BU150096 BF000943 BP345058

highest scoring ESTs for UBC:

AB009010 AK129749 AL535209 AL535583 AL541647 AU076788 AU121100 AU121622 AU122758 AV661858

Unigene Cluster for UBC:

Ubiquitin C

Hs.520348 [show with all ESTs]

Unigene Representative Sequence: AB209782

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for UBC

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d
SP1:					-
SP2:					-		-
SP3:

About this scheme

ECgene alternative splicing isoforms for UBC

6 Ensembl transcripts including schematic representations:

ENST00000339647 ENST00000376781 ENST00000392398 ENST00000339545 ENST00000325925 ENST00000392399

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBC

¹ / ² / ³

8 probe-sets matching UBC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1366_i_at²^{, 3}	U95-A	1	1.00	1.00	0.79	1.00	M26880	0.40	1.00	0.76	1
32335_r_at²^{, 3}	U95-A	2	1.00	0.97	0.93	0.92	AB009010	0.80	1.00	0.91	1
1367_f_at²^{, 3}	U95-A	6	1.00	0.81	0.88	1.03	M26880	0.40	1.00	0.76	1
32334_f_at²^{, 3}	U95-A	7	1.00	0.66	0.70	1.05	AB009010	0.80	1.00	0.91	1
208980_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M26880	0.40	1.00	0.76	1
211296_x_at²^{, 3}	U133-A	7	1.00	0.74	--	--	AB009010	0.80	1.00	0.91	1
208980_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211296_x_at²	U133Plus2	7	1.00	0.74	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.520348
Expression variation in blood from EXPOLDB for UBC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBC gene from 5/26 species (see all 26 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBC¹	--	ubiquitin C	89.76(n) 100(a)	610457 XM_847967.1 XP_853060.1
cow (Bos taurus)	UBC¹	--	ubiquitin C	90.75(n) 99.56(a)	444874 XM_874550.2 XP_879643.1
rat (Rattus norvegicus)	Ubc¹	--	ubiquitin C	88.71(n) 99.71(a)	50522 NM_017314.1 NP_059010.1
mouse (Mus musculus)	Ubc^{1, 5}	5 (64.00 cM)⁵	ubiquitin C^{1, 5}	89.83(n)¹ 99.71(a)¹	22190¹ XM_001471699.1¹ XP_001471749.1¹ AF285161⁵ AF285162⁵ (see all 33)
chicken (Gallus gallus)	UBC¹	--	ubiquitin C	89.25(n) 100(a)	396425 XM_001234599.1 XP_001234600.1

About this table Species with no ortholog for UBC

ENSEMBL Gene Tree for UBC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBC gene

UBB² UBA52² ENSG00000189251²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/97 NCBI SNPs in UBC are shown (see all 97 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 22)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7135151^1,2	A,C,F,H	123962008(+)	`TACAGT/GTCATA`	1	--	ng5¹		4		EU EA WA	420
	rs2070625^1,2	C,F,H	123965239(-)	`GAAAAG/ATAGTC`	1	--	ut5¹		7		EA MN EU WA	2966
	rs13624^1,2	C,F,H	123965120(-)	`GTCGCA/GGTTCT`	1	--	ut5¹		4		EU EA WA	412
	rs7304748^1,2	A,F,H	123966520(+)	`CAAAAA/GAAAGA`	1	--	ng3¹ trp³		2		EU WA	234
	rs2070624^1,2	C,F	123965492(-)	`GCTCCG/CGGTGC`	1	--	ut5¹		1		EA	710
	rs12810858^1,2	F	123967260(+)	`TGGTTA/GTTGAA`	1	--	ng3¹		2		NA	182
--	rs8397^1,2	F	123965103(-)	`TGGATC/TGCTGT`	1	--	ut5¹		2		MN	372
	rs3803141^1,2	H	123966824(-)	`ATCCTG/TCCAAT`	1	--	ng3¹		4		EU EA WA	414
--	rs6488957^1,2	C	123966159(+)	`TCCCAA/GCCTTA`	1	--	ng3¹		0	--	--	--	--
--	rs7137123^1,2	C	123963703(+)	`ATCAGA/GAGGAA`	1	S/P	mis¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for UBC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 191340

2 Novoseek disease relationships for UBC gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mammary tumor	45.44	1	2379587 (1)
tumors	0.00	1	17510243 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/177 PubMed articles for UBC gene (see all 177 ):

Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. (PubMed id 11872750)^{1, 2, 3} Marinovic A.C....Price S.R. (2002)
Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PubMed id 14745543)^{1, 3, 4} Tachikui H.... Inoue I. (2003)
Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. (PubMed id 9504932)^{1, 3, 4} Nenoi M.... Kawano A. (1998)
Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product. (PubMed id 9644242)^{1, 3, 4} Kim N.S.... Kato S. (1998)
Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells. (PubMed id 8917096)^{1, 3, 4} Nenoi M.... Tsuji H. (1996)
Localization of the human UBC polyubiquitin gene to chromosome band 12q24.3. (PubMed id 1315303)^{2, 3} Board P.G....Webb G.C. (1992)
Cloning and sequence analysis of a cDNA encoding poly-ubiquitin in human ovarian granulosa cells. (PubMed id 2820408)^{3, 4} Einspanier R.... Scheit K.H. (1987)
The human ubiquitin multigene family: some genes contain multiple directly repeated ubiquitin coding sequences. (PubMed id 2988935)^{3, 4} Wiborg O....Vuust J. (1985)
The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. (PubMed id 18599482)³ Winborn B.J....Paulson H.L. (2008)
Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ubiquitination and endocytosis. (PubMed id 18632619)³ Sehat B....Larsson O. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7316	HGNC: 12468	AceView: UBC	Ensembl:ENSG00000150991	euGenes: HUgn7316
ECgene: UBC	H-InvDB: UBC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for UBC	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBC		Antibodies for UBC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for UBC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search OriGene for UBC

Search Tocris compounds for UBC

	Proteins for UBC
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for UBC

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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UBC Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for UBC

Summaries
for UBC

Genomic Location
for UBC

Proteins
for UBC

Protein Domains/
Families
for UBC

Gene Function
for UBC

Pathways & Interactions
for UBC

Drugs & Compounds
for UBC

Transcripts
for UBC

Expression
for UBC

Orthologs
for UBC

Paralogs
for UBC

SNPs/Variants
for UBC

Disorders & Mutations
for UBC

Medical News
for UBC

Publications
for UBC

Search for UBC

Genome Databases showing UBC

Other Databases showing UBC

Specialized Databases showing UBC

Licensable Technologies
for UBC

Services
for UBC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBC Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor UBC

Summariesfor UBC

Genomic Locationfor UBC

Proteinsfor UBC

Protein Domains/Familiesfor UBC

Gene Functionfor UBC

Pathways & Interactionsfor UBC

Drugs & Compoundsfor UBC

Transcriptsfor UBC

Expression for UBC

Orthologsfor UBC

Paralogsfor UBC

SNPs/Variantsfor UBC

Disorders & Mutationsfor UBC

Medical Newsfor UBC

Publicationsfor UBC

Search for UBC

Genome Databases showing UBC

Other Databases showing UBC

Specialized Databases showing UBC

Licensable Technologiesfor UBC

Servicesfor UBC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBC

Summaries
for UBC

Genomic Location
for UBC

Proteins
for UBC

Protein Domains/
Families
for UBC

Gene Function
for UBC

Pathways & Interactions
for UBC

Drugs & Compounds
for UBC

Transcripts
for UBC

Expression
for UBC

Orthologs
for UBC

Paralogs
for UBC

SNPs/Variants
for UBC

Disorders & Mutations
for UBC

Medical News
for UBC

Publications
for UBC

Licensable Technologies
for UBC

Services
for UBC