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UBC Gene

protein-coding   GIFtS: 66
GCID: GC12M125396

Ubiquitin C

  See UBC-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin C1 2
polyubiquitin-C1 2
HMG202

External Ids:    HGNC: 124681   Entrez Gene: 73162   Ensembl: ENSG000001509917   OMIM: 1913405   UniProtKB: P0CG483   

Export aliases for UBC gene to outside databases

Previous GC identifers: GC12M124151 GC12M125142 GC12M123749 GC12M123921 GC12M122360


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBC Gene:
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation
of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which
ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle
regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. (provided by
RefSeq, Aug 2010)

GeneCards Summary for UBC Gene:
UBC (ubiquitin C) is a protein-coding gene. Diseases associated with UBC include limb-girdle muscular dystrophy type 2h, and spinocerebellar ataxia type 3. GO annotations related to this gene include protease binding. An important paralog of this gene is UBB.

UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently
bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer
linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the
initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target
protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may
be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and
in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase
modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in
endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription
factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or
Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
roles, such as in activation of protein kinases, and in signaling

Gene Wiki entry for UBC (Ubiquitin C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBC gene promoter:
         Max1   AP-2alpha isoform 3   Sp1   AP-2alpha isoform 2   AP-2alpha isoform 4   AP-2alpha   MRF-2   AP-2alphaA   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBC promoter sequence
   Search Chromatin IP Primers for UBC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.3   Ensembl cytogenetic band:  12q24.31   HGNC cytogenetic band: 12q24.3

UBC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBC gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M125396:  view genomic region     (about GC identifiers)

Start:
125,396,150 bp from pter      End:
125,401,914 bp from pter
Size:
5,765 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48 (See protein sequence)
Recommended Name: Polyubiquitin-C precursor  
Size: 685 amino acids; 77039 Da
Miscellaneous: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of
ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin
precursor with exact head to tail repeats, the number of repeats differ between species and strains
Miscellaneous: For the sake of clarity sequence features are annotated only for the first chain, and are not
repeated for each of the following chains
Selected PDB 3D structures from and Proteopedia for UBC (see all 150):
1C3T (3D)        1CMX (3D)        1D3Z (3D)        1F9J (3D)        1FXT (3D)        1G6J (3D)    
Secondary accessions: P02248 P02249 P02250 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888
Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Explore the universe of human proteins at neXtProt for UBC: NX_P0CG48

Explore proteomics data for UBC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys6, Lys11, Lys27, Lys29, Lys33, Lys48, Lys63
  • Modification sites at PhosphoSitePlus

  • See UBC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_066289.3  
    ENSEMBL proteins: 
     ENSP00000441543   ENSP00000443053   ENSP00000344818   ENSP00000440205   ENSP00000442800  
     ENSP00000445337   ENSP00000439492   ENSP00000438289   ENSP00000441238   ENSP00000437452  
     ENSP00000441556   ENSP00000438394  
    Reactome Protein details: P0CG48

    UBC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Enzo Life Sciences proteins for UBC
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UBC
    GenScript Custom Purified and Recombinant Proteins Services for UBC
    Novus Biologicals UBC Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBC

     
    Search eBioscience for Proteins for UBC 

    UBC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UBC
    Browse R&D Systems for Antibodies
    OriGene Antibodies for UBC
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    Abcam antibodies for UBC
    Cloud-Clone Corp. Antibodies for UBC
    Search ThermoFisher Antibodies for UBC
    LSBio Antibodies in human, mouse, rat for UBC

    UBC Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for UBC
    Enzo Life Sciences assays for UBC
    Cloud-Clone Corp. ELISAs for UBC
    Cloud-Clone Corp. CLIAs for UBC
    Search eBioscience for ELISAs for UBC 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin_dom
     IPR019956 Ubiquitin

    Graphical View of Domain Structure for InterPro Entry P0CG48

    ProtoNet protein and cluster: P0CG48

    UniProtKB/Swiss-Prot: UBC_HUMAN, P0CG48
    Similarity: Belongs to the ubiquitin family
    Similarity: Contains 9 ubiquitin-like domains


    Find genes that share domains with UBC           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBC_HUMAN, P0CG48
    Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently
    bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer
    linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the
    initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target
    protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may
    be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and
    in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase
    modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in
    endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription
    factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
    Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or
    Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
    roles, such as in activation of protein kinases, and in signaling

         Genatlas biochemistry entry for UBC:
    poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI--
    GO:0005515protein binding IPI16256071
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with UBC           About GenesLikeMe


    Phenotypes:
         9 GenomeRNAi human phenotypes for UBC:
     Cell division defect  Decreased cell number, increas  Decreased homologous recombina  Decreased nuclei size in G2M 
     Decreased viability of wild-ty  Increased cell death HMECs cel  Increased gamma-H2AX phosphory  Increased number of mitotic ce 
     Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubc):
     cellular  embryogenesis  growth/size/body  hematopoietic system  liver/biliary system 
     mortality/aging 

    Find genes that share phenotypes with UBC           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ubctm11Rrk for UBC

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBC

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBC:
    hsa-mir-18a-5p (MIRT050710), hsa-mir-615-3p (MIRT039711), hsa-mir-24-3p (MIRT030628), hsa-mir-324-3p (MIRT042909), hsa-mir-296-3p (MIRT038409), hsa-mir-877-5p (MIRT037302), hsa-mir-221-3p (MIRT046896), hsa-mir-769-3p (MIRT039075)

    Block miRNA regulation of human, mouse, rat UBC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBC (see all 11):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UBC
    Predesigned siRNA for gene silencing in human, mouse, rat UBC

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for UBC

    Clone
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    OriGene ORF clones in mouse, rat for UBC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBC (NM_021009)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBC
    Addgene plasmids for UBC 

    Cell Line
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    In Situ Assay
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    Flow Cytometry
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    eBioscience FlowRNA Probe Sets ( VA1-10203 VA4-11236 VA6-10503) for UBC 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBC_HUMAN, P0CG48: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    nucleus4
    cytoskeleton2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--
    GO:0030666endocytic vesicle membrane TAS--

    Find genes that share ontologies with UBC           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBC About   (see all 62)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Assembly of the pre-replicative complex0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Ubiquitin-dependent degradation of Cyclin D10.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    2Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    Signaling by TGF-beta Receptor Complex0.60
    TGFBR1 LBD Mutants in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    3Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    4Signaling by FGFR
    Signaling by FGFR0.91
    Signaling by EGFR in Cancer0.82
    Signaling by FGFR in disease0.91
    Signalling by NGF0.71
    Signaling by ERBB20.89
    Signaling by constitutively active EGFR0.00
    Signaling by EGFR0.83
    Downregulation of ERBB2-ERBB3 signaling0.00
    5Toll Like Receptor 7/8 (TLR7/8) Cascade
    Toll Like Receptor 9 (TLR9) Cascade0.93
    MyD88 dependent cascade initiated on endosome0.69
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    Toll Like Receptor 3 (TLR3) Cascade0.69


    Find genes that share SuperPaths with UBC           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBC (see all 17)
        Remodeling of Adherens Junctions
    TRAF Pathway
    BRCA1 Pathway
    CDK5 Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)

    Selected GeneGo (Thomson Reuters) Pathways for UBC (see all 23)
        Normal wtCFTR traffic / Sorting endosome formation
    Proteolysis Putative ubiquitin pathway
    Immune response MIF-JAB1 signaling
    Regulation of degradation of wt-CFTR
    Immune response IL-12 signaling pathway

    2 BioSystems Pathways for UBC
        DNA Replication
    Proteasome Degradation

    Selected Reactome Pathways for UBC (see all 83)
        NOTCH1 Intracellular Domain Regulates Transcription
    FCERI mediated NF-kB activation
    Regulation of innate immune responses to cytosolic DNA
    Orc1 removal from chromatin
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    1 Kegg Pathway  (Kegg details for UBC):
        PPAR signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBC: 
              Parkinson's Disease in human mouse rat
              Housekeeping Genes PCR Array in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBC (P0CG481, 2, 3 ENSP000003448184) via UniProtKB, MINT, STRING, and/or I2D (see all 7471)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PSMD4P550361, 2, 3, ENSP000003578794EBI-3390054,EBI-359318 MINT-7308936 MINT-50198 MINT-7308992 MINT-7309088 MINT-50256 MINT-7299166 MINT-7309023 MINT-7261503 MINT-7309056 MINT-50255 MINT-7309110 I2D: score=11 STRING: ENSP00000357879
    ADRM1Q161861, 2, 3, ENSP000002530034EBI-3390054,EBI-954387 MINT-7310443 MINT-7310399 MINT-7310429 MINT-7310499 MINT-7310471 MINT-7904643 MINT-7310415 MINT-7309220 MINT-7310485 MINT-7310457 I2D: score=2 STRING: ENSP00000253003
    ENSG00000232804P081072, 3, ENSP000003930874MINT-6735120 I2D: score=1 STRING: ENSP00000393087
    HSPA1AP081072, 3, ENSP000003648024MINT-6735120 I2D: score=1 STRING: ENSP00000364802
    ENSG00000212866P081072, 3MINT-6735120 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 83):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0000187activation of MAPK activity TAS--
    GO:0000209protein polyubiquitination TAS--

    Find genes that share ontologies with UBC           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBC

    1 DrugBank Compound for UBC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    N-Formylmethionine-- --target--10592235

    3 Novoseek inferred chemical compound relationships for UBC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    finrozole 90.5 1 14982857 (1)
    porphobilinogen 52.2 1 16458257 (1)
    dexamethasone 0 4 11872750 (3), 16954342 (1)



    Find genes that share compounds with UBC           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBC gene: 
    NM_021009.6  

    Unigene Cluster for UBC:

    Ubiquitin C
    Hs.520348  [show with all ESTs]
    Unigene Representative Sequence: AB209782
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000536769(uc021rge.1) ENST00000538617 ENST00000339647(uc001ugs.4 uc001ugt.3 uc001ugv.3 uc001ugw.3)
    ENST00000541272 ENST00000540351(uc009zyf.1) ENST00000541645 ENST00000535131
    ENST00000544481 ENST00000546271 ENST00000540700 ENST00000535859 ENST00000536661
    ENST00000542416 ENST00000546120
    miRNA
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    Block miRNA regulation of human, mouse, rat UBC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBC (see all 11):
    hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-519c-3p hsa-miR-519a hsa-miR-519b-3p hsa-miR-93
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UBC
    Predesigned siRNA for gene silencing in human, mouse, rat UBC
    Clone
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    OriGene clones in human, mouse for UBC (see all 6)
    OriGene ORF clones in mouse, rat for UBC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBC (NM_021009)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBC
    Addgene plasmids for UBC 
    Primer
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    Browse OriGene qPCR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBC
      QuantiTect SYBR Green Assays in human, mouse, rat UBC
      QuantiFast Probe-based Assays in human, mouse, rat UBC
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-10203 VA4-11236 VA6-10503) for UBC 

    Additional mRNA sequence: 

    AB009010.1 AB209782.1 AF052164.1 AK026846.1 AK056939.1 AK097415.1 AK098827.1 AK129749.1 
    AK291539.1 AL117514.1 AY732488.1 AY819759.1 BC000449.2 BC008955.2 BC014880.1 BC039193.1 
    BC080583.1 BC093445.1 M17597.1 

    Selected DOTS entries (see all 206):

    DT.100892635  DT.100892528  DT.91842147  DT.100892593  DT.91946866  DT.92042678  DT.100892554  DT.100892552 
    DT.92066176  DT.100892660  DT.121203278  DT.121203045  DT.121203277  DT.95079787  DT.100892562  DT.91739649 
    DT.121203022  DT.100892515  DT.100048108  DT.121203341  DT.95247243  DT.100892525  DT.92060112  DT.121203136 

    Selected AceView cDNA sequences (see all 225):

    AI523439 AA594938 AU106419 BM818112 CB130133 CF135013 BM826662 BU150096 
    BG292097 CA308734 BQ719762 AA578722 CA434838 CB132490 BQ721025 AI952618 
    AA828162 BQ889973 AA176657 BU196155 W58577 BQ898470 BP381377 BQ423460 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBC    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d
    SP1:              -                           
    SP2:              -     -                     
    SP3:                                          


    ECgene alternative splicing isoforms for UBC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UBC Expression
    About this image


    UBC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Brain (Nervous System)
             Cerebral Cortex
    UBC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520348
        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBC: 
              Parkinson's Disease in human mouse rat
              Housekeeping Genes PCR Array in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBC gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubc1 , 5 ubiquitin C1, 5 89.83(n)1
    99.71(a)1
      5 (64.18 cM)5
    221901  NM_019639.41  NP_062613.31 
     1253859655 
    chicken
    (Gallus gallus)
    Aves UBB6
    Polyubiquitin-B Ubiquitin
    75(a)
    1 → many
    19(6584723-6586315)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC054976.12   -- 82.96(n)    BC054976.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049473.12   -- 87.98(n)    BC049473.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubi-p63E1 , 3 response to heat protein degradation
    tagging3
    Ubiquitin-63E1
    100(a)
    (best of 3)3
    82.29(n)1
    99.71(a)1
      3 63F53
    384561  NM_001274454.11  NP_001261383.11 
    worm
    (Caenorhabditis elegans)
    Secernentea ubq-16
    Protein UBQ-1, isoform a
    71(a)
    1 → many
    III(5940244-5943838) WBGene00006727
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UBI4(YLL039C)4 Ubiquitin, becomes conjugated to proteins, marking more   --   12(65207-64062) 850620  NP_013061.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBQ81 UBQ8 70.6(n)
    76.25(a)
      820137  NM_111814.1  NP_566357.1 
    rice
    (Oryza sativa)
    Liliopsida AK121590.12   -- 82.36(n)    AK121590.1 


    ENSEMBL Gene Tree for UBC (if available)
    TreeFam Gene Tree for UBC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBC gene
    UBB2  UBA522  ZFAND42  UBBP42  
    15 SIMAP similar genes for UBC using alignment to 15 protein entries:     UBC_HUMAN (see all proteins):
    UBA52    UBB    DKFZp434K0435    UbC    RPS27A    UBBP4
    NEDD8    NEDD8-MDP1    FAU    ZFAND4    PARK2    UBD
    RAD23A    ISG15    UBL4A

    Find genes that share paralogs with UBC           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for UBC (see all 8)
    PGOHUM00000258675 PGOHUM00000256799 PGOHUM00000244830 PGOHUM00000240380 PGOHUM00000259880


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for UBC (see all 250)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1122052081,2
    C--125210902(+) CATTCC/TGTTAC 1 -- ds50013Minor allele frequency- T:0.04CSA WA NA 240
    rs1907940641,2
    --125210923(+) ACCCAA/CAAACC 1 -- ds50010--------
    rs1930728061,2
    --125210995(+) AACTTA/CTTTTT 1 -- ds50010--------
    rs768019291,2
    F--125211000(+) CTTTTT/GTGAGT 1 -- ds50011Minor allele frequency- G:0.03EA 120
    rs1838974491,2
    --125211057(+) TGCAAC/TCTCTG 1 -- ds50010--------
    rs1387074191,2
    C--125211066(+) TGCTTC/TGTAGG 1 -- ds50010--------
    rs1428139101,2
    C--125211129(+) TCACTA/GCCACA 1 -- ds50010--------
    rs1881762361,2
    --125211208(+) CTTTTA/GTTTGC 1 -- ds50010--------
    rs71351511,2
    C,F,A,H--125211229(+) TACAGT/GTCATA 1 -- ds500131Minor allele frequency- G:0.46NS EA NA MN WA 3582
    rs760628461,2
    F--125211273(+) ACCGTT/GACCAC 1 -- ds50011Minor allele frequency- G:0.03WA 118

    HapMap Linkage Disequilibrium report for UBC (125396150 - 125401914 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBC:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1696538CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBC
    DNA2.0 Custom Variant and Variant Library Synthesis for UBC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191340    OMIM disorders: --

    9 diseases for UBC:    
    About MalaCards
    limb-girdle muscular dystrophy type 2h    spinocerebellar ataxia type 3    myoclonus-dystonia    chromosome 5q deletion
    glomuvenous malformation    congenital central hypoventilation syndrome    central hypoventilation syndrome    mulibrey nanism
    cherubism

    1 disease from the University of Copenhagen DISEASES database for UBC:
    Parkinson's disease

    Find genes that share disorders with UBC           About GenesLikeMe

    2 Novoseek inferred disease relationships for UBC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 42.8 1 2379587 (1)
    tumors 0 1 17510243 (1)

    Genetic Association Database (GAD): UBC
    Human Genome Epidemiology (HuGE) Navigator: UBC (20 documents)

    Export disorders for UBC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBC gene, integrated from 10 sources (see all 3150):
    (articles sorted by number of sources associating them with UBC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1. (PubMed id 11872750)1, 3, 9 Marinovic A.C....Price S.R. (J. Biol. Chem. 2002)
    2. Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PubMed id 14745543)1, 2, 9 Tachikui H.... Inoue I. (J. Mol. Evol. 2003)
    3. Cloning of human polyubiquitin cDNAs and a ubiquitin-binding assay involving its in vitro translation product. (PubMed id 9644242)1, 2, 9 Kim N.S.... Kato S. (J. Biochem. 1998)
    4. Higher frequency of concerted evolutionary events in rodents than in man at the polyubiquitin gene VNTR locus. (PubMed id 9504932)1, 2, 9 Nenoi M.... Kawano A. (Genetics 1998)
    5. Heterogeneous structure of the polyubiquitin gene UbC of HeLa S3 cells. (PubMed id 8917096)1, 2, 9 Nenoi M.... Tsuji H. (Gene 1996)
    6. Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21. (PubMed id 21399617)1, 2 Ye Y....Komander D. (EMBO Rep. 2011)
    7. Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. (PubMed id 20622874)1, 2 Bremm A.... Komander D. (Nat. Struct. Mol. Biol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. The emerging complexity of protein ubiquitination. (PubMed id 19754430)1, 2 Komander D. (Biochem. Soc. Trans. 2009)
    10. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PubMed id 18719106)1, 2 Motegi A.... Myung K. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7316 HGNC: 12468 AceView: UBC Ensembl:ENSG00000150991 euGenes: HUgn7316
    ECgene: UBC Kegg: 7316 H-InvDB: UBC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UBC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UBC gene:
    Search GeneIP for patents involving UBC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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