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Aliases for UBC Gene

Aliases for UBC Gene

  • Ubiquitin C 2 3 5
  • Polyubiquitin-C 2 3
  • HMG20 3

External Ids for UBC Gene

Previous GeneCards Identifiers for UBC Gene

  • GC12M124151
  • GC12M125142
  • GC12M123749
  • GC12M123921
  • GC12M125396
  • GC12M122360

Summaries for UBC Gene

Entrez Gene Summary for UBC Gene

  • This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]

GeneCards Summary for UBC Gene

UBC (Ubiquitin C) is a Protein Coding gene. Diseases associated with UBC include Apocrine Adenoma and Congenital Granular Cell Tumor. Among its related pathways are Interferon gamma signaling and Activated TLR4 signalling. GO annotations related to this gene include poly(A) RNA binding and protease binding. An important paralog of this gene is UBB.

UniProtKB/Swiss-Prot for UBC Gene

  • Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene Wiki entry for UBC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBC Gene

Genomics for UBC Gene

Regulatory Elements for UBC Gene

Enhancers for UBC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F124937 1.6 FANTOM5 ENCODE 13.5 -22.2 -22150 5.0 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 DHX37 UBC BRI3BP NCOR2 TRD-GTC2-10 RPL22P19
GH12F124861 1.4 FANTOM5 ENCODE 11 +54.2 54221 3.2 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 KLF13 SP3 SP5 UBC ENSG00000270130 RFLNA LOC105370050 GC12P124823
GH12F124850 1.3 Ensembl ENCODE 11 +63.4 63385 6.6 MLX ARID4B DMAP1 ZNF48 YY1 FOS ZNF263 SP5 NFYC MXD4 SCARB1 DHX37 UBC RFLNA LOC105370050 GC12P124823
GH12F124451 1.9 FANTOM5 Ensembl ENCODE 5.7 +462.1 462149 6.8 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 TBX21 EIF2B1 ATP6V0A2 NCOR2 UBC ZNF664 LOC105370047 ENSG00000255965
GH12F124913 1.7 FANTOM5 ENCODE 5.4 -1.8 -1815 12.7 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 ZNF263 DHX37 NCOR2 LOC100131779 ENSG00000256814 ENSG00000270130 ENSG00000269938 ENSG00000270061 ENSG00000269997 SCARB1 BRI3BP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBC on UCSC Golden Path with GeneCards custom track

Promoters for UBC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000439020 1568 4801 CREB3L1 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 SP3

Genomic Location for UBC Gene

Chromosome:
12
Start:
124,911,604 bp from pter
End:
124,917,368 bp from pter
Size:
5,765 bases
Orientation:
Minus strand

Genomic View for UBC Gene

Genes around UBC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBC Gene

Proteins for UBC Gene

  • Protein details for UBC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG48-UBC_HUMAN
    Recommended name:
    Polyubiquitin-C
    Protein Accession:
    P0CG48
    Secondary Accessions:
    • P02248
    • P02249
    • P02250
    • P62988
    • Q29120
    • Q6LBL4
    • Q6LDU5
    • Q8WYN8
    • Q91887
    • Q91888
    • Q9BWD6
    • Q9BX98
    • Q9UEF2
    • Q9UEG1
    • Q9UEK8
    • Q9UPK7

    Protein attributes for UBC Gene

    Size:
    685 amino acids
    Molecular mass:
    77039 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • For the sake of clarity sequence features are annotated only for the first chain, and are not repeated for each of the following chains.
    • Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains.

    Three dimensional structures from OCA and Proteopedia for UBC Gene

neXtProt entry for UBC Gene

Post-translational modifications for UBC Gene

  • Ubiquitin: Phosphorylated at Ser-65 by PINK1 during mitophagy. Phosphorylated ubiquitin specifically binds and activates parkin (PARK2), triggering mitophagy (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291). Phosphorylation does not affect E1-mediated E2 charging of ubiquitin but affects discharging of E2 enzymes to form polyubiquitin chains. It also affects deubiquitination by deubiquitinase enzymes such as USP30 (PubMed:25527291).
  • Ubiquitination at Lys 6, Lys 11, Lys 27, Lys 29, Lys 33, Lys 48, and Lys 63
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for UBC Gene

Domains & Families for UBC Gene

Protein Domains for UBC Gene

Graphical View of Domain Structure for InterPro Entry

P0CG48

UniProtKB/Swiss-Prot:

UBC_HUMAN :
  • Contains 9 ubiquitin-like domains.
  • Belongs to the ubiquitin family.
Domain:
  • Contains 9 ubiquitin-like domains.
Family:
  • Belongs to the ubiquitin family.
genes like me logo Genes that share domains with UBC: view

No data available for Gene Families for UBC Gene

Function for UBC Gene

Molecular function for UBC Gene

GENATLAS Biochemistry:
poly-ubiquitin,gene C,encoding 9 tandem repeats of the ubiquitin unit
UniProtKB/Swiss-Prot Function:
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene Ontology (GO) - Molecular Function for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21185309
GO:0005515 protein binding IPI 8702753
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with UBC: view
genes like me logo Genes that share phenotypes with UBC: view

Animal Models for UBC Gene

MGI Knock Outs for UBC:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBC

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBC Gene

Localization for UBC Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBC Gene

Ubiquitin: Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBC gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 4
endosome 4
endoplasmic reticulum 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 16502470
GO:0005634 nucleus IEA,IDA 21630459
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with UBC: view

Pathways & Interactions for UBC Gene

SuperPathway Contained pathways
1 Regulation of activated PAK-2p34 by proteasome mediated degradation
.78
.32
2 RET signaling
3 Activated TLR4 signalling
4 HIV Life Cycle
.45
5 Signaling by NOTCH1
genes like me logo Genes that share pathways with UBC: view

Gene Ontology (GO) - Biological Process for UBC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS --
GO:0000165 MAPK cascade TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000209 protein polyubiquitination TAS --
genes like me logo Genes that share ontologies with UBC: view

No data available for SIGNOR curated interactions for UBC Gene

Drugs & Compounds for UBC Gene

(3) Drugs for UBC Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
N-Formylmethionine Experimental Pharma Target 0

(1) Additional Compounds for UBC Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBC: view

Transcripts for UBC Gene

Unigene Clusters for UBC Gene

Ubiquitin C:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for UBC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d
SP1: -
SP2: - -
SP3:

Relevant External Links for UBC Gene

GeneLoc Exon Structure for
UBC
ECgene alternative splicing isoforms for
UBC

Expression for UBC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBC Gene

mRNA differential expression in normal tissues according to GTEx for UBC Gene

This gene is overexpressed in Muscle - Skeletal (x4.6) and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for UBC Gene

This gene is overexpressed in Heart (29.0), Brain (21.2), and Skin (14.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for UBC Gene



Protein tissue co-expression partners for UBC Gene

NURSA nuclear receptor signaling pathways regulating expression of UBC Gene:

UBC

SOURCE GeneReport for Unigene cluster for UBC Gene:

Hs.520348
genes like me logo Genes that share expression patterns with UBC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UBC Gene

Orthologs for UBC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBC Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 100 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia UBB 35
  • 99 (a)
ManyToMany
UBC 34
  • 94.01 (n)
cow
(Bos Taurus)
Mammalia UBC 34 35
  • 90.75 (n)
mouse
(Mus musculus)
Mammalia Ubc 34 16 35
  • 89.83 (n)
dog
(Canis familiaris)
Mammalia UBC 34
  • 89.76 (n)
rat
(Rattus norvegicus)
Mammalia Ubc 34
  • 88.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 75 (a)
OneToMany
chicken
(Gallus gallus)
Aves UBB 35
  • 75 (a)
OneToMany