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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBB Gene

protein-coding GIFtS: 64
GCID: GC17P016301

ubiquitin B

Explore 31 diseases affiliated with
UBB via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin B¹ ²		UBA52²
FLJ25987¹		UBC²
MGC8385¹		Polyubiquitin B²
RPS27A²		Polyubiquitin-B¹

External Ids:	HGNC: 12463¹	Entrez Gene: 7314²	Ensembl: ENSG00000170315⁷	OMIM: 191339⁵	UniProtKB: P0CG47³

Export aliases for UBB gene to outside databases

Previous GC identifers: GC17P016646 GC17P017395 GC17P016227 GC17P016484 GC17P016225 GC17P016150

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBB:

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent,

nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover.

Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation.

Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation,

suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct

repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a

polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed

in patients with Alzheimer's and Down syndrome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47

Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,

it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via

different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the

ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different

functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair;

Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation;

Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is

involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as

well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains

formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of

target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is

free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in

signaling

Gene Wiki entry for UBB (Ubiquitin B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the UBB gene promoter:
CREB HNF-1 deltaCREB GATA-2 HNF-1A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBB promoter sequence

Search SABiosciences Chromatin IP Primers for UBB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12-p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p12-p11.2

UBB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBB gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P016301: view genomic region (about GC identifiers)

Start:	16,284,112 bp from pter	End:	16,287,220 bp from pter
Size:	3,109 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47 (See protein sequence)

Recommended Name: Polyubiquitin-B precursor

Size: 229 amino acids; 25762 Da

Subcellular location: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)

Miscellaneous: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitin

fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with

exact head to tail repeats, the number of repeats differ between species and strains

Miscellaneous: The mRNA encoding variant UBB(+1) is produced by an unknown mechanism involving the deletion of a GT

dinucleotide in the close proximity of a GAGAG motif (PubMed:9422699). This variant mRNA is found in normal brain, but

the encoded protein accumulates only in brain neurofibrillary tangles and neuritic plaques in Alzheimer disease and

other tauopathies, as well as polyglutaminopathies (PubMed:14597671). UBB(+1) variant cannot be used for

polyubiquitination, is not effectively degraded by the proteasome when ubiquitinated and ubiquitinated UBB(+1) is

refractory to disassembly by deubiquitinating enzymes (DUBs). In healthy brain, UBB(+1) C-terminus can be cleaved by

UCHL3 (PubMed:21762696)

Miscellaneous: For a better understanding, features related to ubiquitin are only indicated for the first chain

Secondary accessions: P02248 P02249 P02250 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6

Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Explore the universe of human proteins at neXtProt for UBB: NX_P0CG47

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P0CG47

UBB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_061828.1

ENSEMBL proteins:

ENSP00000464594 ENSP00000304697 ENSP00000463156 ENSP00000437475 ENSP00000379180

ENSP00000379178 ENSP00000464510 ENSP00000464745

Reactome Protein details: P0CG47
Human Recombinant Protein Products for UBB:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for UBB (Ubiquitin, Octa-Ubiquitin/Ub8, Penta-Ubiquitin/Ub5, Ubiquitin+1, Tetra-Ubiquitin/Ub4, Hexa-Ubiquitin/Ub6, Tri-Ubiquitin/Ub3, Di-Ubiquitin/Ub2)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for UBB
	GenScript Custom Purified and Recombinant Proteins Services for UBB
	Novus Biologicals UBB Proteins
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for UBB

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--
GO:0005886	plasma membrane	TAS	--
GO:0010008	endosome membrane	TAS	--
GO:0030666	endocytic vesicle membrane	TAS	--

UBB for ontologies About GeneDecksing

UBB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of UBB
	R&D Systems Antibodies for UBB (Ubiquitin, Ubiquitin+1, Ubiquitin/Ubiquitin+1)
	OriGene Antibodies (see all 5): UBB OriGene Custom Antibody Services for UBB
	GenScript Superior Antibodies for UBB
	Novus Biologicals UBB Antibodies
	Abcam antibodies for UBB
	Uscn Antibodies for UBB
	ThermoFisher Antibodies for UBB

Assay Products for UBB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for UBB (Ubiquitin+1) (see all)
	GenScript Custom Assay Services for UBB
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for UBB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBB for domains About GeneDecksing

4 InterPro domains/families:

IPR019956 Ubiquitin_subgr

IPR019954 Ubiquitin_CS

IPR000626 Ubiquitin

IPR019955 Ubiquitin_supergroup

Graphical View of Domain Structure for InterPro Entry P0CG47

ProtoNet protein and cluster: P0CG47

UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47

Similarity: Belongs to the ubiquitin family

Similarity: Contains 3 ubiquitin-like domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: UBB_HUMAN, P0CG47