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UBB Gene

protein-coding   GIFtS: 63

GC17P016225
ubiquitin B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ25987 1, 2
MGC8385 1, 2
OTTHUMP00000064960 2
OTTHUMP00000064961 2
UBA80 3
UBCEP1 3
UBCEP2 3
Descriptions
polyubiquitin B 2
ubiquitin B 2
External Ids
HGNC: 124631
Entrez Gene: 73142
UniProtKB: P629883
Ensembl: ENSG000001703157
Search outside databases for aliases for UBB gene

Previous GC identifers: GC17P016646 GC17P017395 GC17P016227 GC17P016484

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBB:
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for
ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal
proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and
presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively
transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also
involved in regulation of gene expression. This gene consists of three direct repeats of the
ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a
polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this
protein has been noticed in patients with Alzheimer's and Down syndrome. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988
Function: Protein modifier which can be covalently attached to target lysines either as a monomer
or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to
their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked
polymer does not lead to proteasomal degradation and may be required for numerous functions,
including maintenance of chromatin structure, regulation of gene expression, stress response,
ribosome biogenesis and DNA repair

Gene Wiki entry for UBB (Ubiquitin_B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the UBB gene  

Entrez Gene cytogenetic band: 17p12-p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p12-p11.2

UBB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P016225:     (about GC identifiers)

Start:
16,225,092 bp from pter
End:
16,226,779 bp from pter
Size:
1,688 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010718.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988 (See protein sequence)
Recommended Name: Ubiquitin  
Size: 76 amino acids; 8565 Da
Subcellular location: Cytoplasm. Nucleus
Miscellaneous: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail
repeats, the number of repeats differ between species and strains. In some species there is a
final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single
copy of ubiquitin fused to a ribosomal protein (either L40 or S27a)
PDB structures from and Proteopedia :
1C3T (3D)    1CMX (3D)    1D3Z (3D)    1F9J (3D)    1FXT (3D)    1G6J (3D)    1GJZ (3D)    1NBF (3D)    
1OGW (3D)    1Q5W (3D)    1S1Q (3D)    1SIF (3D)    1TBE (3D)    1UBI (3D)    1UBQ (3D)    1XD3 (3D)    
1XQQ (3D)    1YX5 (3D)    1YX6 (3D)    1ZGU (3D)    1ZO6 (3D)    2AYO (3D)    2BGF (3D)    2DEN (3D)    
2FUH (3D)    2G45 (3D)    2GBJ (3D)    2GBK (3D)    2GBM (3D)    2GBN (3D)    2GBR (3D)    2HTH (3D)    
2IBI (3D)    2J7Q (3D)    2JF5 (3D)    2JRI (3D)    2JY6 (3D)    2JZZ (3D)    2K25 (3D)    2K6D (3D)    
2K8B (3D)    2K8C (3D)    2NR2 (3D)    2O6V (3D)    2OJR (3D)    2PE9 (3D)    2PEA (3D)    2W9N (3D)    
2Z59 (3D)    2ZCB (3D)    2ZVN (3D)    2ZVO (3D)    3BY4 (3D)    3C0R (3D)    3DVG (3D)    3DVN (3D)    
3EEC (3D)    3EFU (3D)    3EHV (3D)    
Secondary accessions: P02248 P02249 P02250 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6 Q9BX98
Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Post-translational modifications:

  • Several types of polymeric chains can be formed, depending on the lysine used for the assembly1


  • REFSEQ proteins: NP_061828.1  

    ENSEMBL proteins: 
    ENSP00000379178 ENSP00000379180 ENSP00000304697 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant UBB Protein
    Sigma-Aldrich Proteins for UBB  
    R&D Systems Recombinant & Natural Proteins for UBB (Ubiquitin, Ubiquitin+1)
    Enzo Life Sciences proteins for UBB
    Recombinant Proteins from Abcam (Ubiquitin +1, Ubiquitin)
    Human Recombinant Proteins from Abnova (UBB)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IC14528304
    GO:0005654 nucleoplasm EXP11231585 11931757 15029244
    GO:0005737 cytoplasm IEA--
    GO:0005829 cytosol EXP9660940 10995389 11285280 11742988 11931757 12070128 12218189 12593796 12820959 15469984 15781449 16407834
    About this table

    Antibodies for UBB: 
    Invitrogen Antibodies for UBB
    Millipore Mono- and Polyclonal Antibodies for the study of UBB
    Sigma-Aldrich Antibody Arrays and Antibodies for UBB
    R&D Systems Antibodies for UBB (Ubiquitin, Ubiquitin+1)
    Antibodies from Abcam (Ubiquitin +1, Ubiquitin), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (UBB)
    Novus Biologicals Antibody for UBB

    Assays for UBB: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    R&D Systems ELISAs for UBB (Ubiquitin+1)         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin
     IPR019955 Ubiquitin_supergroup
     IPR019956 Ubiquitin_subgroup


       GeneDecks  UBB for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P62988

    ProtoNet protein and cluster: P62988

    UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988
    Similarity: Belongs to the ubiquitin family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBB)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (UBB)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018955

                  Applied Biosystems Silencer® siRNAs for UBB

                  Sigma-Aldrich siRNA and siRNA Panels for UBB  
                         Sigma-Aldrich shRNA Panels and shRNA for UBB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for UBB
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018955
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018955
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_018955 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018955

    UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988
    Function: Protein modifier which can be covalently attached to target lysines either as a monomer
    or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to
    their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked
    polymer does not lead to proteasomal degradation and may be required for numerous functions,
    including maintenance of chromatin structure, regulation of gene expression, stress response,
    ribosome biogenesis and DNA repair

    Genatlas biochemistry entry for UBB:
    poly-ubiquitin,gene B,encoding 3 ubiquitin units

    7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubb):

    adipose tissuebehavior/neurologicalendocrine/exocrine glandgrowth/sizehomeostasis/metabolism
    nervous systemreproductive system

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI14528304
    GO:0030528 transcription regulator activity IDA14528304
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/10 Invitrogen iPath™ Online BioAtlas - Pathways for UBB (see all 10 ) (Maps provided by GeneGo):
     FGFR signaling pathway
     NGF activation of NF-kB
     Angiotensin signaling via beta-arrestin
     TCR and CD28 co-stimulation in activation of NF-kB
     T cell receptor signaling pathway

       GeneDecks  UBB for the pathways selected above  
    About GeneDecksing

    5/19 Millipore Pathways for UBB (see all 19 )
     DNA damage ATM/ATR regulation of G1/S checkpoint
     Meiosis
     Proteolysis Putative SUMO-1 pathway
     Proteolysis Putative ubiquitin pathway
     Immune response IL-1 signaling pathway

       GeneDecks  UBB for the pathways selected above  
    About GeneDecksing

    5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for  UBB  (Your Favorite Gene powered by Ingenuity) (see all 10
     GABA Receptor Signaling
     Cell Cycle: G2/M DNA Damage Checkpoint Regulation
     Protein Ubiquitination Pathway
     Clathrin-mediated Endocytosis
     NRF2-mediated Oxidative Stress Response

       GeneDecks  UBB for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for UBB):
     hsa05012 Parkinson's disease

       GeneDecks  UBB for the pathways selected above  
    About GeneDecksing

    5/484 Interacting proteins for UBB (P629881, 2 ENSP000003046973) via UniProtKB, MINT, and/or STRING (see all 484 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011062, ENSP000003672073MINT-7025800 MINT-3374653 STRING (score=.872)
    TP53P046371, 2EBI-413034, EBI-366083 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-6799774 MINT-7013815 MINT-4052207 MINT-5114741 EBI-413034, EBI-366083 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-6799774 MINT-7013815 MINT-4052207 MINT-5114741
    MDM2Q009871, 2EBI-413034, EBI-389668 MINT-6801380 MINT-6823761 MINT-6801709 MINT-7013831 MINT-4304119 MINT-6799770 EBI-413034, EBI-389668 MINT-6801380 MINT-6823761 MINT-6801709 MINT-7013831 MINT-4304119 MINT-6799770
    SMURF2Q9HAU41, 2EBI-413034, EBI-396727 MINT-7104207 EBI-413034, EBI-396727 MINT-7104207
    WWP2O003081, 2EBI-413034, EBI-743923 MINT-7104232 EBI-413034, EBI-743923 MINT-7104232
    About this table

    5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006464 protein modification process IEA--
    GO:0007049 cell cycle TAS12367500
    GO:0007411 axon guidance TAS12367500
    GO:0016567 protein ubiquitination IDA14528304
    GO:0030433 ER-associated protein catabolic process TAS11597332
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for UBB

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBB)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (UBB)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018955

                  Sigma-Aldrich siRNA and siRNA Panels for UBB  
                         Sigma-Aldrich shRNA Panels and shRNA for UBB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018955  

    REFSEQ mRNAs for UBB gene: 

    NM_018955.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018955  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018955
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018955
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_018955 

    Additional cDNA sequence: 

    AK300882.1 BC000379.2 BC009301.2 BC015127.1 BC026301.1 BC031027.1 BC038999.1 BC046123.2 

    24/75 DOTS entries (see all 75 ):

    DT.101987385  DT.453494  DT.95177969  DT.100053650  DT.91683659  DT.100060245  DT.100701722  DT.121010219 
    DT.95152337  DT.91934183  DT.91846307  DT.92473108  DT.121010202  DT.100701739  DT.121010253  DT.121010317 
    DT.95335624  DT.98083702  DT.87013772  DT.92473005  DT.40120625  DT.121010262  DT.91729876  DT.100701736 

    24/2143 AceView cDNA sequences (see all 2143 ):

    CB108871 CN479697 BP370474 AA617826 BU790222 BM790636 BU626545 BQ688374 
    BM838999 BM663402 AA373552 CB122344 CD722081 BU786198 BQ215647 BQ682480 
    BQ058960 F28733 BQ222899 AA977404 AA369403 BM465120 CA434729 BQ653207 

    highest scoring ESTs for UBB:

    AA045863 AA054702 AA056468 AA071131 AA081124 AA092344 AA093473 AA099797 AA115669 AA132756 

    Unigene Clusters for UBB:

    Ubiquitin B
    Hs.356190  [show with all ESTs], Hs.719097  [show with all ESTs]
    Unigene Representative Sequences: BF572309, BQ059946


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBB

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
    SP1:        -     -     -                     
    SP2:                    -                     
    SP3:                                          

    About this scheme

    ECgene alternative splicing isoforms for UBB

    3 Ensembl transcripts including schematic representations:
    ENST00000395837  ENST00000395839  ENST00000302182  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    UBB expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for UBB

    1 / 2 / 3

    4 probe-sets matching UBB gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1323_at2, 3 U95-A 3 1.00 0.81 0.96 0.99 X04803 0.20 1.00 0.72 1

    32153_s_at2, 3 U95-A 3 1.00 0.68 0.97 1.01 U49869 0.20 1.00 0.72 1

    200633_at2, 3 U133-A 3 1.00 0.67 -- -- NM_018955 0.60 1.00 0.82 1

    200633_at2 U133Plus2 3 1.00 0.67 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene clusters: Hs.356190 Hs.719097

    Expression variation in blood from EXPOLDB for UBB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for UBB gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    UBB1   -- ubiquitin B 94.76(n)
    99.56(a)
    479513  XM_536651.2  XP_536651.2 
    chimpanzee
    (Pan troglodytes)
    UBB1   -- ubiquitin B 99.27(n)
    100(a)
    468372  NM_001009117.1  NP_001009117.1 
    mouse
    (Mus musculus)
    Ubb5 11 (35.00 cM) ubiquitin B   -- X51703 
    chicken
    (Gallus gallus)
    UBB1   -- ubiquitin B 88.01(n)
    100(a)
    396190  XM_001233376.1  XP_001233377.1 
    fruit fly
    (Drosophila melanogaster)
    Ubi-p63E3 3 63F5 response to heat protein degradation
    tagging
    100(a)
    (best of 2)
      --
    About this table        Species with no ortholog for UBB

    ENSEMBL Gene Tree for UBB
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for UBB gene
    UBA522  ENSG000001892512  UBC2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/14 NCBI SNPs in UBB are shown (see all 14 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 12)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10069581,2
    C,F,H16223179(+) GTTTCC/TGGTCC 1 -- ng517Minor allele frequency- T:0.05EU EA WA NA 536
    --
    rs45848621,2
    A16223407(+) atctcC/Ttgagc 1 -- ng510--------
    rs37443261,2
    H16225146(-) ACAAAG/CCCAAC 1 -- ut514Minor allele frequency- C:0.00EU EA WA 410
    --
    rs572085721,2
    --16224135(+) TTTTTA/GTATTT 1 -- ng510--------
    --
    rs600190481,2
    --16224147(+) TAGTAC/GAGACG 1 -- ng510--------
    --
    rs562241451,2
    --16223684(+) GAACCA/CGGGAG 1 -- ng510--------
    --
    rs98930571,2
    --16223850(+) tggagA/Gtcaag 1 -- ng510--------
    --
    rs598588331,2
    --16224121(+) ACGCCC/TGGCTA 1 -- ng510--------
    --
    rs620742261,2
    --16224385(+) CCGAGA/GCGGGT 1 -- ng510--------
    --
    rs584523361,2
    --16224117(+) CACCAC/TGCCCG 1 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for UBB (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 191339   disorders: 119540  

    2 Novoseek disease relationships for UBB gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 56.06 8 11124436 (1), 10911966 (1), 10666673 (1), 15582744 (1) (see all 5)
    down syndrome 48.74 1 10666673 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/125 PubMed articles for UBB gene (see all 125 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 7314 HGNC: 12463 AceView: UBB Ensembl:ENSG00000170315 euGenes: HUgn7314
    ECgene: UBB H-InvDB: UBB
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for UBB Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for UBB:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for UBB-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for UBB Antibodies for UBB
     Explore super-pooled esiRNAs Proteins for UBB
     Lentivirus-delivered shRNAs for UBB Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Ubiquitin +1, Ubiquitin)
     Antibodies (Ubiquitin +1, Ubiquitin)
     Search OriGene for UBB
     Search Tocris compounds for UBB




     Proteins for UBB
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for UBB

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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