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UBB Gene

protein-coding   GIFtS: 64
GCID: GC17P016301

Ubiquitin B

  See UBB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin B1 2
Polyubiquitin B1 2
polyubiquitin-B2

External Ids:    HGNC: 124631   Entrez Gene: 73142   Ensembl: ENSG000001703157   OMIM: 1913395   UniProtKB: P0CG473   

Export aliases for UBB gene to outside databases

Previous GC identifers: GC17P016646 GC17P017395 GC17P016227 GC17P016484 GC17P016225 GC17P016150


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBB Gene:
This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin has a major role in targeting
cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin
structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor
protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein.
This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence.
Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last
repeat. An aberrant form of this protein has been detected in patients with Alzheimer's disease and Down
syndrome. Pseudogenes of this gene are located on chromosomes 1, 2, 13, and 17. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for UBB Gene:
UBB (ubiquitin B) is a protein-coding gene. Diseases associated with UBB include cleft palate, isolated, and mulibrey nanism. An important paralog of this gene is UBA52.

UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47
Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently
bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer
linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the
initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target
protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may
be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and
in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase
modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in
endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription
factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or
Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
roles, such as in activation of protein kinases, and in signaling

Gene Wiki entry for UBB (Ubiquitin B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBB gene promoter:
         CREB   HNF-1   deltaCREB   GATA-2   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBB promoter sequence
   Search Chromatin IP Primers for UBB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p12-p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p12-p11.2

UBB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBB gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P016301:  view genomic region     (about GC identifiers)

Start:
16,284,112 bp from pter      End:
16,286,059 bp from pter
Size:
1,948 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47 (See protein sequence)
Recommended Name: Polyubiquitin-B precursor  
Size: 229 amino acids; 25762 Da
Miscellaneous: Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of
ubiquitin fused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin
precursor with exact head to tail repeats, the number of repeats differ between species and strains
Miscellaneous: The mRNA encoding variant UBB(+1) is produced by an unknown mechanism involving the deletion of a
GT dinucleotide in the close proximity of a GAGAG motif (PubMed:9422699). This variant mRNA is found in normal
brain, but the encoded protein accumulates only in brain neurofibrillary tangles and neuritic plaques in
Alzheimer disease and other tauopathies, as well as polyglutaminopathies (PubMed:14597671). UBB(+1) variant
cannot be used for polyubiquitination, is not effectively degraded by the proteasome when ubiquitinated and
ubiquitinated UBB(+1) is refractory to disassembly by deubiquitinating enzymes (DUBs). In healthy brain, UBB(+1)
C-terminus can be cleaved by UCHL3 (PubMed:21762696)
Miscellaneous: For a better understanding, features related to ubiquitin are only indicated for the first chain
Secondary accessions: P02248 P02249 P02250 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888
Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Explore the universe of human proteins at neXtProt for UBB: NX_P0CG47

Explore proteomics data for UBB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys6, Lys11, Lys27, Lys29, Lys33, Lys48, Lys63
  • Modification sites at PhosphoSitePlus

  • See UBB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001268645.1  NP_001268646.1  NP_001268647.1  NP_001268648.1  NP_001268649.1  NP_061828.1  

    ENSEMBL proteins: 
     ENSP00000464594   ENSP00000304697   ENSP00000463156   ENSP00000437475   ENSP00000379180  
     ENSP00000379178   ENSP00000464510  
    Reactome Protein details: P0CG47

    UBB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for UBB (Octa-Ubiquitin/Ub8, Hexa-Ubiquitin/Ub6, Tri-Ubiquitin/Ub3, Di-Ubiquitin/Ub2, Ubiquitin, Ubiquitin+1, Penta-Ubiquitin/Ub5, Tetra-Ubiquitin/Ub4)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for UBB
    GenScript Custom Purified and Recombinant Proteins Services for UBB
    Novus Biologicals UBB Proteins
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for UBB 

    UBB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of UBB
    R&D Systems Antibodies for UBB (Ubiquitin, Ubiquitin+1, Ubiquitin/Ubiquitin+1)
    OriGene Antibodies for UBB
    OriGene Custom Antibody Services for UBB
    Novus Biologicals UBB Antibodies
    Abcam antibodies for UBB (P62988, P0CG48, P0CG47)
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for UBB
    LSBio Antibodies in human, mouse, rat for UBB

    UBB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for UBB
    R&D Systems ELISAs for UBB (Ubiquitin+1)         (see all)
    GenScript Custom Assay Services for UBB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for UBB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR019954 Ubiquitin_CS
     IPR000626 Ubiquitin_dom
     IPR019956 Ubiquitin

    Graphical View of Domain Structure for InterPro Entry P0CG47

    ProtoNet protein and cluster: P0CG47

    UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47
    Similarity: Belongs to the ubiquitin family
    Similarity: Contains 3 ubiquitin-like domains


    Find genes that share domains with UBB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBB_HUMAN, P0CG47
    Function: Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently
    bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer
    linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the
    initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target
    protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may
    be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and
    in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase
    modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in
    endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription
    factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling.
    Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or
    Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct
    roles, such as in activation of protein kinases, and in signaling

         Genatlas biochemistry entry for UBB:
    poly-ubiquitin,gene B,encoding 3 ubiquitin units

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14755250
         
    Find genes that share ontologies with UBB           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for UBB:
     Decreased Hepatitis C virus re  Decreased cell number, increas  Decreased viability  Decreased viability of wild-ty 
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubb):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism 
     nervous system  reproductive system 

    Find genes that share phenotypes with UBB           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBB

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBB:
    hsa-mir-92a-1-5p (MIRT038925), hsa-mir-1287-5p (MIRT035905), hsa-mir-100-5p (MIRT048512), hsa-mir-99a-5p (MIRT048633), hsa-mir-18a-3p (MIRT040746), hsa-mir-148b-5p (MIRT038186), hsa-mir-615-3p (MIRT039790), hsa-mir-26b-5p (MIRT029681), hsa-mir-181b-5p (MIRT047262), hsa-mir-760 (MIRT036732)

    Block miRNA regulation of human, mouse, rat UBB using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate UBB:
    hsa-miR-3143
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for UBB
    Predesigned siRNA for gene silencing in human, mouse, rat UBB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBB

    Clone
    Products:
         
    OriGene clones in human, mouse for UBB (see all 8)
    OriGene ORF clones in mouse, rat for UBB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: UBB (NM_001069)
    Sino Biological Human cDNA Clone for UBB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBB
    Addgene plasmids for UBB 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for UBB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBB_HUMAN, P0CG47: Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    endosome4
    nucleus4
    cytoskeleton2
    plasma membrane2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0010008endosome membrane TAS--
    GO:0030666endocytic vesicle membrane TAS--

    Find genes that share ontologies with UBB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for UBB About   (see all 77)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1CDK-mediated phosphorylation and removal of Cdc6
    CDK-mediated phosphorylation and removal of Cdc60.94
    Assembly of the pre-replicative complex0.89
    Regulation of activated PAK-2p34 by proteasome mediated degradation0.94
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Ubiquitin-dependent degradation of Cyclin D10.94
    G1/S DNA Damage Checkpoints0.87
    Ubiquitin-dependent degradation of Cyclin D0.94
    CDT1 association with the CDC6-ORC-origin complex0.87
    2Inactivation of APC/C via direct inhibition of the APC/C complex
    APC/C-Cdc20 mediated degradation of Cyclin B0.64
    Common schema of ubiquitination0.33
    3Loss of Function of SMAD2/3 in Cancer
    Transcriptional activity of SMAD2/SMAD3-SMAD4 heterotrimer0.72
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/SMAD3-SMAD4 heterotrimer regulates transcription0.72
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    Loss of Function of SMAD2/3 in Cancer0.60
    Signaling by TGF-beta Receptor Complex0.60
    TGFBR1 LBD Mutants in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    4Signaling by NOTCH1 PEST Domain Mutants in Cancer
    Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants0.79
    Signaling by NOTCH1 HD Domain Mutants in Cancer0.79
    Signaling by NOTCH1 PEST Domain Mutants in Cancer0.79
    Constitutive Signaling by NOTCH1 PEST Domain Mutants0.79
    FBXW7 Mutants and NOTCH1 in Cancer0.79
    Signaling by NOTCH1 t(7;9)(NOTCH1-M1580 K2555) Translocation Mutant0.79
    Signaling by NOTCH1 in Cancer0.79
    NOTCH1 Intracellular Domain Regulates Transcription0.68
    5Signaling by FGFR
    Signaling by FGFR0.91
    Signaling by EGFR in Cancer0.82
    Signaling by FGFR in disease0.91
    Signalling by NGF0.71
    Signaling by ERBB20.89
    Signaling by constitutively active EGFR0.00
    Signaling by EGFR0.83
    Downregulation of ERBB2-ERBB3 signaling0.00


    Find genes that share SuperPaths with UBB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for UBB (see all 17)
        Remodeling of Adherens Junctions
    TRAF Pathway
    BRCA1 Pathway
    CDK5 Pathway
    Inhibition of Ribosome Biogenesis by p14(ARF)

    Selected GeneGo (Thomson Reuters) Pathways for UBB (see all 23)
        Normal wtCFTR traffic / Sorting endosome formation
    Proteolysis Putative ubiquitin pathway
    Immune response MIF-JAB1 signaling
    Regulation of degradation of wt-CFTR
    Immune response IL-12 signaling pathway

    2 BioSystems Pathways for UBB
        Parkinsons Disease Pathway
    Proteasome Degradation


    Selected Reactome Pathways for UBB (see all 83)
        NOTCH1 Intracellular Domain Regulates Transcription
    FCERI mediated NF-kB activation
    Regulation of innate immune responses to cytosolic DNA
    Orc1 removal from chromatin
    TAK1 activates NFkB by phosphorylation and activation of IKKs complex


    1 Kegg Pathway  (Kegg details for UBB):
        Parkinson's disease

        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBB: 
              Parkinson's Disease in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for UBB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBB (P0CG471, 2, 3 ENSP000003046974) via UniProtKB, MINT, STRING, and/or I2D (see all 705)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DUSP1P285621, 3, ENSP000002392234EBI-413034,EBI-975493 I2D: score=3 STRING: ENSP00000239223
    GGA3Q9NZ521, 3, ENSP000002455414EBI-413034,EBI-447404 I2D: score=3 STRING: ENSP00000245541
    SMURF2Q9HAU41, 3, ENSP000002624354EBI-413034,EBI-396727 I2D: score=2 STRING: ENSP00000262435
    CCDC50Q8IVM01, 3, ENSP000003762504EBI-413034,EBI-723996 I2D: score=1 STRING: ENSP00000376250
    DAXXQ9UER73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 83):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000086G2/M transition of mitotic cell cycle TAS--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter TAS--
    GO:0000187activation of MAPK activity TAS--
    GO:0000209protein polyubiquitination TAS--

    Find genes that share ontologies with UBB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBB

    1 DrugBank Compound for UBB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (4s)-5-Fluoro-L-Leucine-- --target--17139284 17016423 10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBB gene (6 alternative transcripts): 
    NM_001281716.1  NM_001281717.1  NM_001281718.1  NM_001281719.1  NM_001281720.1  NM_018955.3  

    Unigene Cluster for UBB:

    Ubiquitin B
    Hs.356190  [show with all ESTs]
    Unigene Representative Sequence: BF572309
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577958 ENST00000302182(uc010vwe.1 uc002gpx.3) ENST00000577640
    ENST00000535788 ENST00000578649 ENST00000395839 ENST00000395837 ENST00000578706

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate UBB:
    hsa-miR-3143
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: UBB (NM_001069)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBB
    Addgene plasmids for UBB 
    Primer
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    OriGene qPCR primer pairs and template standards for UBB
    OriGene qSTAR qPCR primer pairs in human, mouse for UBB
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat UBB
      QuantiTect SYBR Green Assays in human, mouse, rat UBB
      QuantiFast Probe-based Assays in human, mouse, rat UBB

    Additional mRNA sequence: BT020104.1 

    Selected DOTS entries (see all 55):

    DT.100053650  DT.95177969  DT.101987385  DT.100060245  DT.453494  DT.91683659  DT.100701722  DT.95152337 
    DT.121010317  DT.92473108  DT.100701739  DT.91846307  DT.91934183  DT.95335624  DT.121010219  DT.100701736 
    DT.87013772  DT.98083702  DT.121010262  DT.121010253  DT.100701732  DT.100701743  DT.121010340  DT.121010357 

    Selected AceView cDNA sequences (see all 2143):

    CB134497 CA867446 BU786198 BM833530 CB145997 CB114180 BQ682772 BQ005738 
    BU846354 H93196 CA843664 CR607481 BQ682480 CA411992 BQ723728 AA307562 
    CK430355 CB122426 BP347169 BM824718 BQ932486 BM264025 BU182682 CD367431 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for UBB    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
    SP1:        -     -     -                     
    SP2:                    -                     
    SP3:                                          


    ECgene alternative splicing isoforms for UBB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAGCAAAAA
    UBB Expression
    About this image


    UBB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    UBB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356190
        Pathway & Disease-focused RT2 Profiler PCR Arrays including UBB: 
              Parkinson's Disease in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for UBB gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubb5 ubiquitin B   --   11 (38.46 cM) 62551171 
    chicken
    (Gallus gallus)
    Aves UBB1 ubiquitin B 88.01(n)
    100(a)
      396190  XM_415105.4  XP_415105.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    10(a)
    many ↔ many
    GL343297.1(325230-354411)
    zebrafish
    (Danio rerio)
    Actinopterygii UBC6
    ubiquitin C
    50(a)
    1 → many
    5(43682726-43714907) ENSDARG00000002369
    fruit fly
    (Drosophila melanogaster)
    Insecta Ubi-p63E3 response to heat protein degradation
    tagging
    100(a)
    (best of 2)
      3 63F5   --
    worm
    (Caenorhabditis elegans)
    Secernentea ubq-16
    Protein UBQ-1, isoform a
    27(a)
    1 → many
    III(5940244-5943838) WBGene00006727
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RPL40A6
    RPL40B6
    Fusion protein, identical to Rpl40Bp, that is clea...
    Fusion protein, identical to Rpl40Ap, that is clea...
    70(a)
    70(a)
    many ↔ many
    many ↔ many
    IX(68708-69528) YIL148W
    XI(617996-618750) YKR094C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons UBQ111 UBQ11 79.53(n)
    96.05(a)
      825847  NM_001036508.1  NP_001031585.1 


    ENSEMBL Gene Tree for UBB (if available)
    TreeFam Gene Tree for UBB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBB gene
    UBA522  UBC2  ZFAND42  UBBP42  
    15 SIMAP similar genes for UBB using alignment to 6 protein entries:     UBB_HUMAN (see all proteins):
    DKFZp434K0435    UBA52    UbC    UBC    RPS27A    UBBP4
    NEDD8    NEDD8-MDP1    FAU    PARK2    RAD23A    UBD
    ZFAND4    ISG15    UBL4A

    Find genes that share paralogs with UBB           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for UBB
    PGOHUM00000248657 PGOHUM00000244419 PGOHUM00000259767


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBB (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10069571,2
    C,F,A,H--16148954(+) AGCAGG/TATCAG 1 -- us2k136Minor allele frequency- T:0.24NS EA NA WA CSA 4883
    rs113319341,2
    C--16149020(+) TGCACT/-TTTTT 1 -- us2k1 trp31Minor allele frequency- -:0.50CSA 2
    rs1822842961,2
    --16271308(+) AAGCCC/TGGCCA 1 -- us2k10--------
    rs10069581,2
    C,F,H--16271380(+) GTTTCC/TGGTCC 1 -- us2k117Minor allele frequency- T:0.07NA NS EA WA 1782
    rs1434277981,2
    --16271430(+) GTTCTC/TGGGCC 1 -- us2k10--------
    rs1480663931,2
    C--16271555(+) GCACGA/GTGGTT 1 -- us2k10--------
    rs45848621,2
    C,A--16271608(+) ATCTCC/TTGAGC 1 -- us2k15Minor allele frequency- T:0.25CSA WA NA EA 361
    rs1868000161,2
    --16271668(+) AACAAA/CAAAAA 1 -- us2k10--------
    rs1426191741,2
    --16271726(+) AGGCCA/GAGGCA 1 -- us2k10--------
    rs1460023241,2
    --16271794(+) ATCTGC/TACTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBB (16284112 - 16286059 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for UBB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715702CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBB
    DNA2.0 Custom Variant and Variant Library Synthesis for UBB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 191339   
    OMIM disorders: 119540  
    3 diseases for UBB:    
    About MalaCards
    cleft palate, isolated    mulibrey nanism    down syndrome

    1 disease from the University of Copenhagen DISEASES database for UBB:
    Parkinson's disease

    Find genes that share disorders with UBB           About GenesLikeMe

    3 Novoseek inferred disease relationships for UBB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 55.9 8 11124436 (1), 10911966 (1), 10666673 (1), 15582744 (1) (see all 5)
    down syndrome 46.8 1 10666673 (1)
    tumors 0 2 19798105 (2)


    Export disorders for UBB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBB gene, integrated from 10 sources (see all 242):
    (articles sorted by number of sources associating them with UBB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PubMed id 14745543)1, 2, 9 Tachikui H.... Inoue I. (J. Mol. Evol. 2003)
    2. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. (PubMed id 9422699)1, 2, 9 van Leeuwen F.W.... Hol E.M. (Science 1998)
    3. Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12. (PubMed id 2154095)1, 3, 9 Webb G.C....Board P.G. (Am. J. Hum. Genet. 1990)
    4. The emerging complexity of protein ubiquitination. (PubMed id 19754430)1, 2 Komander D. (Biochem. Soc. Trans. 2009)
    5. Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PubMed id 18719106)1, 2 Motegi A.... Myung K. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    6. The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)1, 2 Vasilescu J.... Figeys D. (J. Proteome Res. 2007)
    7. Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. (PubMed id 16543144)1, 2 Huang F.... Sorkin A. (Mol. Cell 2006)
    8. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (Nature 2006)
    9. Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. (PubMed id 16443603)1, 2 Cripps D.... Yang A.J. (J. Biol. Chem. 2006)
    10. Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. (PubMed id 15466860)1, 2 Okumura F.... Nakayama K. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7314 HGNC: 12463 AceView: UBB Ensembl:ENSG00000170315 euGenes: HUgn7314
    ECgene: UBB Kegg: 7314 H-InvDB: UBB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for UBB Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UBB gene:
    Search GeneIP for patents involving UBB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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