UBB Gene
protein-coding GIFtS : 64
GCID: GC17 P016301
ubiquitin B
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Aliasesfor UBB gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Ubiquitin B 1 2 UBA522 FLJ259871 UBC2 MGC83851 Polyubiquitin B2 RPS27A2 Polyubiquitin-B1
Export aliases for UBB gene to outside databases Previous GC identifers: GC17P016646 GC17P017395 GC17P016227 GC17P016484 GC17P016225 GC17P016150
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Summariesfor UBB gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for UBB : This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47 Function : Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling Gene Wiki entry for UBB (Ubiquitin B)
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Genomic Viewsfor UBB gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000017.10 NC_018928.1 NT_010718.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the UBB gene promoter: CREB HNF-1 deltaCREB GATA-2 HNF-1A Other transcription factors Search SABiosciences Chromatin IP Primers for UBB Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat UBB
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 17p12-p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p12-p11.2 UBB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P016301: view genomic region
(about GC identifiers )
Start:
16,284,112 bp from pter
End:
16,287,220 bp from pter
Size:
3,109 bases
Orientation:
plus strand
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Proteinsfor UBB gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47 (See
protein sequence )Recommended Name: Polyubiquitin-B precursor Size : 229 amino acids; 25762 Da
Subcellular location : Ubiquitin: Cytoplasm (By similarity). Nucleus (By similarity)
Miscellaneous : Ubiquitin is encoded by 4 different genes. UBA52 and RPS27A genes code for a single copy of ubiquitinfused to the ribosomal proteins L40 and S27a, respectively. UBB and UBC genes code for a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains
Miscellaneous : The mRNA encoding variant UBB(+1) is produced by an unknown mechanism involving the deletion of a GTdinucleotide in the close proximity of a GAGAG motif (PubMed:9422699). This variant mRNA is found in normal brain, but the encoded protein accumulates only in brain neurofibrillary tangles and neuritic plaques in Alzheimer disease and other tauopathies, as well as polyglutaminopathies (PubMed:14597671). UBB(+1) variant cannot be used for polyubiquitination, is not effectively degraded by the proteasome when ubiquitinated and ubiquitinated UBB(+1) is refractory to disassembly by deubiquitinating enzymes (DUBs). In healthy brain, UBB(+1) C-terminus can be cleaved by UCHL3 (PubMed:21762696)
Miscellaneous : For a better understanding, features related to ubiquitin are only indicated for the first chain
Secondary accessions : P02248 P02249 P02250 P62988 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7 Explore the universe of human proteins at neXtProt for UBB: NX_P0CG47 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P0CG47 UBB Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_061828.1 ENSEMBL proteins: ENSP00000464594 ENSP00000304697 ENSP00000463156 ENSP00000437475 ENSP00000379180 ENSP00000379178 ENSP00000464510 ENSP00000464745 Reactome Protein details: P0CG47 Human Recombinant Protein Products for UBB: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
UBB for ontologies About GeneDecksing UBB Antibody Products: Assay Products for UBB:
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Protein
Domains / Familiesfor UBB gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
UBB for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P0CG47 ProtoNet protein and cluster: P0CG47
UniProtKB/Swiss-Prot: UBB_HUMAN, P0CG47 Similarity : Belongs to the ubiquitin familySimilarity : Contains 3 ubiquitin-like domains
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Functionfor UBB gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: UBB_HUMAN, P0CG47 Function : Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound,it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling
Genatlas biochemistry entry for UBB : poly-ubiquitin,gene B,encoding 3 ubiquitin units Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
UBB for ontologies About GeneDecksing Phenotypes: 6 GenomeRNAi human phenotypes for UBB : 7 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ubb) :
UBB for phenotypes About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBB (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBB (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UBB (NM_001069 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBB Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UBB
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBB
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Pathways & Interactionsfor UBB gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways  - 5/89 super-pathways (see all 89 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ubiquitinated Orc1 is degraded by the proteasome 2 Signal Transduction 3 TRAF6 Mediated Induction of proinflammatory cytokines 4 Signaling by NOTCH1 t(7 9)(NOTCH1:M1580_K2555) Translocation Mutant 5 Signaling by FGFR
Pathway sources See GeneCards unified pathways Show all pathways 5/19 EMD Millipore Pathways for UBB (see all 19 )5/17 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for UBB (see all 17 )5/23 GeneGo (Thomson Reuters) Pathways for UBB (see all 23 )2 BioSystems Pathways for UBB 5/242
Reactome Pathways for UBB (see all 242 )1
Kegg Pathway (Kegg details for UBB) :
UBB for pathways About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBB STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/580 Interacting proteins for UBB (P0CG47 1 , 2 , 3 ENSP00000304697 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 580 )Interactant Interaction Details GeneCard External ID(s) DUSP1 P28562 1 , 3 , ENSP00000239223 4 EBI-413034,EBI-975493 I2D:
score=3 STRING: ENSP00000239223 GGA3 Q9NZ52 1 , 3 , ENSP00000245541 4 EBI-413034,EBI-447404 I2D:
score=3 STRING: ENSP00000245541 SMURF2 Q9HAU4 1 , 3 , ENSP00000262435 4 EBI-413034,EBI-396727 I2D:
score=2 STRING: ENSP00000262435 CCDC50 Q8IVM0 1 , 3 , ENSP00000376250 4 EBI-413034,EBI-723996 I2D:
score=1 STRING: ENSP00000376250 RABGEF1 Q9UJ41 1 , 3 , ENSP00000284957 4 EBI-413034,EBI-913954 I2D:
score=2 STRING: ENSP00000284957
About this table Gene Ontology (GO): 5/61 biological process terms (GO ID links to tree view) (see all 61 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000075 cell cycle checkpoint
TAS -- GO:0000080 G1 phase of mitotic cell cycle
TAS -- GO:0000082 G1/S transition of mitotic cell cycle
TAS -- GO:0000084 S phase of mitotic cell cycle
TAS -- GO:0000122 negative regulation of transcription from RNA polymerase II promoter
TAS --
UBB for ontologies About GeneDecksing
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Drugs & Compoundsfor UBB gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for UBB 1 DrugBank Compound for UBB About this table Search CenterWatch for drugs/clinical trials and news about UBB
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Transcriptsfor UBB gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for UBB gene: NM_018955.2 Unigene Clusters for UBB:
Ubiquitin B Hs.356190 [show with all ESTs ] , Hs.741549 [show with all ESTs ] Unigene Representative Sequences: BF572309 , BQ059946 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000577958 ENST00000302182 (uc010vwe.1 uc002gpx.3 ) ENST00000577640 ENST00000535788 ENST00000578649 ENST00000395839 ENST00000395837 ENST00000578706 ENST00000513764 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBB (see all 4 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBB (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: UBB (NM_001069 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for UBB Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat UBB
Additional cDNA sequence: AK129498.1 AK300882.1 BC000379.2 BC009301.2 BC015127.1 BC026301.1 BC031027.1 BC038999.1 BC046123.2
24/83 DOTS entries (see all 83 ): DT.101987385 DT.95177969
DT.453494 DT.100053650 DT.91683659 DT.100060245 DT.100701722 DT.121010219 DT.95152337 DT.121010202 DT.91846307 DT.91934183 DT.92473108 DT.100701739 DT.121010253 DT.121010317 DT.92473005 DT.95335624 DT.40120625 DT.87013772 DT.95152323 DT.100739733 DT.121010262 DT.100701736 24/2143 AceView cDNA sequences (see all 2143 ):
CR590697 CA308576 CA427655 BM450627 BM758310 BM772319 AA488023 BU156001 BU501192 BM791440 BP370474 BQ287858 BM836026 BQ219625 BU632969 H92778 CR620731 AA340542 CN479697 CB126157 BM785142 BM840387 AA953243 CB114180 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for UBB About this scheme ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c SP1 :   -   -   -         SP2 :       -         SP3 :              
ECgene alternative splicing isoforms for UBB
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Expression for UBB gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section UBB expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GTAGCAAAAAAbout this image UBB expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Endoderm-like cells (Generation of hepato... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See UBB Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for UBB SOURCE GeneReport for Unigene clusters: Hs.356190 Hs.741549 SABiosciences Expression via Pathway-Focused PCR Arrays including UBB : Parkinson's Disease in human mouse rat Ubiquitin Ligases in human mouse rat
Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for UBBBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat UBB QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat UBB QIAGEN QuantiFast Probe-based Assays in human , mouse , rat UBB In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBB
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Orthologsfor UBB gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for UBB gene from 6/23 species (see all 23 ) About this table
ENSEMBL Gene Tree for UBB (if available)TreeFam Gene Tree for UBB (if available)
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Paralogsfor UBB gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for UBB gene UBD 2 ISG15 2 UBC 2 UBBP4 2 15 SIMAP similar genes for UBB using alignment to 6 protein entries: UBB_HUMAN (see all proteins ):DKFZp434K0435 UBA52 UBC RPS27A UBBP4 NEDD8 NEDD8-MDP1 FAU PARK2 RAD23A UBD ZFAND4 OASLd ISG15 UBL4A
UBB for paralogs About GeneDecksing 3 Pseudogenes.org Pseudogenes for UBB PGOHUM00000248657 PGOHUM00000244419 PGOHUM00000259767
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Genomic Variantsfor UBB gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 17 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for UBB (16284112 - 16287220 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for UBB: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing UBB
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Disorders
/ Diseasesfor UBB gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
UBB for disorders About GeneDecksing OMIM gene information: 191339 OMIM disorders : 119540 20/31 diseases for UBB (see all 31 ): About MalaCards down syndrome cleft palate, isolated smith-magenis syndrome mulibrey nanism inclusion body myositis lewy body dementia cleft palate myotilinopathy multiple system atrophy myositis fanconi's anemia tauopathy alzheimer's disease neurodegenerative disease dementia parkinson's disease anemia neurodegeneration pancreatic carcinoma breast cancer 3 Novoseek disease relationships for UBB gene About this table
Export disorders for UBB gene to outside databases
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Publicationsfor UBB gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for UBB gene, integrated from 9 sources (see all 223 ): (articles sorted by number of sources associating them with UBB) Utopia : connect your pdf to the dynamic world of online information
Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PubMed id 14745543) 1 , 2 , 9 Tachikui H.... Inoue I. (2003) Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. (PubMed id 9422699) 1 , 2 , 9 van Leeuwen F.W....Hol E.M. (1998) Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12. (PubMed id 2154095) 1 , 3, 9 Webb G.C....Board P.G. (1990) The emerging complexity of protein ubiquitination. (PubMed id 19754430) 1 , 2 Komander D. (2009) Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. (PubMed id 18719106) 1 , 2 Motegi A.... Myung K. (2008) The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973) 1 , 2 Vasilescu J.... Figeys D. (2007) Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. (PubMed id 16543144) 1 , 2 Huang F.... Sorkin A. (2006) DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196) 1 , 2 Zody M.C.... Nusbaum C. (2006) Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. (PubMed id 16443603) 1 , 2 Cripps D.... Yang A.J. (2006) Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. (PubMed id 15466860) 1 , 2 Okumura F.... Nakayama K. (2004)
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Specialized Databases showing UBB gene (According to PharmGKB ,
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About This Section Patent Information for UBB gene: Search GeneIP for patents involving UBB GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor UBB gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for UBB OriGene shRNA RFP for UBB OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for UBB OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for UBB Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for UBB OriGene 3'-UTR Clone for UBB OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for UBB OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for UBB Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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