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UBB Gene

protein-coding GIFtS: 63

GC17P016225

ubiquitin B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ25987 ^¹, ²
MGC8385 ^¹, ²
OTTHUMP00000064960 ^²
OTTHUMP00000064961 ^²
UBA80 ^³
UBCEP1 ^³
UBCEP2 ^³

Descriptions
polyubiquitin B ^²
ubiquitin B ^²

External Ids
HGNC: 12463¹
Entrez Gene: 7314²
UniProtKB: P62988³
Ensembl: ENSG00000170315⁷

Search outside databases for aliases for UBB gene

Previous GC identifers: GC17P016646 GC17P017395 GC17P016227 GC17P016484

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBB:

This gene encodes ubiquitin, one of the most conserved proteins known. Ubiquitin is required for

ATP-dependent, nonlysosomal intracellular protein degradation of abnormal proteins and normal

proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and

presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively

transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also

involved in regulation of gene expression. This gene consists of three direct repeats of the

ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a

polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this

protein has been noticed in patients with Alzheimer's and Down syndrome. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988

Function: Protein modifier which can be covalently attached to target lysines either as a monomer

or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to

their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked

polymer does not lead to proteasomal degradation and may be required for numerous functions,

including maintenance of chromatin structure, regulation of gene expression, stress response,

ribosome biogenesis and DNA repair

Gene Wiki entry for UBB (Ubiquitin_B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the UBB gene

Entrez Gene cytogenetic band: 17p12-p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p12-p11.2

UBB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P016225: (about GC identifiers)

Start:	16,225,092 bp from pter
End:	16,226,779 bp from pter
Size:	1,688 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988 (See protein sequence)

Recommended Name: Ubiquitin

Size: 76 amino acids; 8565 Da

Subcellular location: Cytoplasm. Nucleus

Miscellaneous: Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail

repeats, the number of repeats differ between species and strains. In some species there is a

final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single

copy of ubiquitin fused to a ribosomal protein (either L40 or S27a)

PDB structures from and Proteopedia :

1C3T (3D)

1CMX (3D)

1D3Z (3D)

1F9J (3D)

1FXT (3D)

1G6J (3D)

1GJZ (3D)

1NBF (3D)

1OGW (3D)

1Q5W (3D)

1S1Q (3D)

1SIF (3D)

1TBE (3D)

1UBI (3D)

1UBQ (3D)

1XD3 (3D)

1XQQ (3D)

1YX5 (3D)

1YX6 (3D)

1ZGU (3D)

1ZO6 (3D)

2AYO (3D)

2BGF (3D)

2DEN (3D)

2FUH (3D)

2G45 (3D)

2GBJ (3D)

2GBK (3D)

2GBM (3D)

2GBN (3D)

2GBR (3D)

2HTH (3D)

2IBI (3D)

2J7Q (3D)

2JF5 (3D)

2JRI (3D)

2JY6 (3D)

2JZZ (3D)

2K25 (3D)

2K6D (3D)

2K8B (3D)

2K8C (3D)

2NR2 (3D)

2O6V (3D)

2OJR (3D)

2PE9 (3D)

2PEA (3D)

2W9N (3D)

2Z59 (3D)

2ZCB (3D)

2ZVN (3D)

2ZVO (3D)

3BY4 (3D)

3C0R (3D)

3DVG (3D)

3DVN (3D)

3EEC (3D)

3EFU (3D)

3EHV (3D)

Secondary accessions: P02248 P02249 P02250 Q29120 Q6LBL4 Q6LDU5 Q8WYN8 Q91887 Q91888 Q9BWD6 Q9BX98

Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7

Post-translational modifications:

Several types of polymeric chains can be formed, depending on the lysine used for the assembly¹

REFSEQ proteins: NP_061828.1

ENSEMBL proteins:

ENSP00000379178 ENSP00000379180 ENSP00000304697

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant UBB Protein
	Sigma-Aldrich Proteins for UBB
	R&D Systems Recombinant & Natural Proteins for UBB (Ubiquitin, Ubiquitin+1)
	Enzo Life Sciences proteins for UBB
	Recombinant Proteins from Abcam (Ubiquitin +1, Ubiquitin)
	Human Recombinant Proteins from Abnova (UBB)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IC	14528304
GO:0005654	nucleoplasm	EXP	11231585 11931757 15029244
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	EXP	9660940 10995389 11285280 11742988 11931757 12070128 12218189 12593796 12820959 15469984 15781449 16407834

About this table

Antibodies for UBB:

	Invitrogen Antibodies for UBB
	Millipore Mono- and Polyclonal Antibodies for the study of UBB
	Sigma-Aldrich Antibody Arrays and Antibodies for UBB
	R&D Systems Antibodies for UBB (Ubiquitin, Ubiquitin+1)
	Antibodies from Abcam (Ubiquitin +1, Ubiquitin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (UBB)
	Novus Biologicals Antibody for UBB

Assays for UBB:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for UBB (Ubiquitin+1) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P62988

ProtoNet protein and cluster: P62988

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988

Similarity: Belongs to the ubiquitin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018955

Applied Biosystems Silencer® siRNAs for UBB

Sigma-Aldrich siRNA and siRNA Panels for UBB

Sigma-Aldrich shRNA Panels and shRNA for UBB

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for UBB
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_018955
Myc/DDK tagged cDNA clone in CMV expression vector: NM_018955
untagged cDNA clones in CMV expression vector (see all 2): NM_018955

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_018955

UniProtKB/Swiss-Prot: UBIQ_HUMAN, P62988

Function: Protein modifier which can be covalently attached to target lysines either as a monomer

or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to

their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked

polymer does not lead to proteasomal degradation and may be required for numerous functions,

including maintenance of chromatin structure, regulation of gene expression, stress response,

ribosome biogenesis and DNA repair

Genatlas biochemistry entry for UBB:

poly-ubiquitin,gene B,encoding 3 ubiquitin units

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ubb):

adipose tissue	behavior/neurological	endocrine/exocrine gland	growth/size	homeostasis/metabolism
nervous system	reproductive system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	14528304
GO:0030528	transcription regulator activity	IDA	14528304

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/10 Sigma-Aldrich "Your Favorite Gene" Pathways for UBB (Your Favorite Gene powered by Ingenuity) (see all 10 )

GABA Receptor Signaling
Cell Cycle: G2/M DNA Damage Checkpoint Regulation
Protein Ubiquitination Pathway
Clathrin-mediated Endocytosis
NRF2-mediated Oxidative Stress Response

GeneDecks UBB for the pathways selected above

About GeneDecksing

5/484 Interacting proteins for UBB (P62988^{1, 2} ENSP00000304697³) via UniProtKB, MINT, and/or STRING (see all 484 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MYC	P01106², ENSP00000367207³	MINT-7025800 MINT-3374653 STRING (score=.872)
TP53	P04637¹^,²	EBI-413034, EBI-366083 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-6799774 MINT-7013815 MINT-4052207 MINT-5114741 EBI-413034, EBI-366083 MINT-4051326 MINT-4304004 MINT-4054804 MINT-4304143 MINT-6801380 MINT-6615153 MINT-6541035 MINT-6799774 MINT-7013815 MINT-4052207 MINT-5114741
MDM2	Q00987¹^,²	EBI-413034, EBI-389668 MINT-6801380 MINT-6823761 MINT-6801709 MINT-7013831 MINT-4304119 MINT-6799770 EBI-413034, EBI-389668 MINT-6801380 MINT-6823761 MINT-6801709 MINT-7013831 MINT-4304119 MINT-6799770
SMURF2	Q9HAU4¹^,²	EBI-413034, EBI-396727 MINT-7104207 EBI-413034, EBI-396727 MINT-7104207
WWP2	O00308¹^,²	EBI-413034, EBI-743923 MINT-7104232 EBI-413034, EBI-743923 MINT-7104232

About this table

5/11 Gene Ontology (GO) biological process terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006464	protein modification process	IEA	--
GO:0007049	cell cycle	TAS	12367500
GO:0007411	axon guidance	TAS	12367500
GO:0016567	protein ubiquitination	IDA	14528304
GO:0030433	ER-associated protein catabolic process	TAS	11597332

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for UBB

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (UBB)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (UBB)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018955

Sigma-Aldrich siRNA and siRNA Panels for UBB

Sigma-Aldrich shRNA Panels and shRNA for UBB

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_018955

REFSEQ mRNAs for UBB gene:

NM_018955.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_018955

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018955
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_018955
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_018955

Additional cDNA sequence:

AK300882.1 BC000379.2 BC009301.2 BC015127.1 BC026301.1 BC031027.1 BC038999.1 BC046123.2

24/75 DOTS entries (see all 75 ):

DT.101987385 DT.453494 DT.95177969 DT.100053650 DT.91683659 DT.100060245 DT.100701722 DT.121010219

DT.95152337 DT.91934183 DT.91846307 DT.92473108 DT.121010202 DT.100701739 DT.121010253 DT.121010317

DT.95335624 DT.98083702 DT.87013772 DT.92473005 DT.40120625 DT.121010262 DT.91729876 DT.100701736

24/2143 AceView cDNA sequences (see all 2143 ):

CB108871 CN479697 BP370474 AA617826 BU790222 BM790636 BU626545 BQ688374

BM838999 BM663402 AA373552 CB122344 CD722081 BU786198 BQ215647 BQ682480

BQ058960 F28733 BQ222899 AA977404 AA369403 BM465120 CA434729 BQ653207

highest scoring ESTs for UBB:

AA045863 AA054702 AA056468 AA071131 AA081124 AA092344 AA093473 AA099797 AA115669 AA132756

Unigene Clusters for UBB:

Ubiquitin B

Hs.356190 [show with all ESTs], Hs.719097 [show with all ESTs]

Unigene Representative Sequences: BF572309, BQ059946

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for UBB

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	·	3c
SP1:			-		-		-
SP2:							-
SP3:

About this scheme

ECgene alternative splicing isoforms for UBB

3 Ensembl transcripts including schematic representations:

ENST00000395837 ENST00000395839 ENST00000302182

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

UBB expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for UBB

¹ / ² / ³

4 probe-sets matching UBB gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1323_at²^{, 3}	U95-A	3	1.00	0.81	0.96	0.99	X04803	0.20	1.00	0.72	1
32153_s_at²^{, 3}	U95-A	3	1.00	0.68	0.97	1.01	U49869	0.20	1.00	0.72	1
200633_at²^{, 3}	U133-A	3	1.00	0.67	--	--	NM_018955	0.60	1.00	0.82	1
200633_at²	U133Plus2	3	1.00	0.67	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.356190 Hs.719097
Expression variation in blood from EXPOLDB for UBB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for UBB gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	UBB¹	--	ubiquitin B	94.76(n) 99.56(a)	479513 XM_536651.2 XP_536651.2
chimpanzee (Pan troglodytes)	UBB¹	--	ubiquitin B	99.27(n) 100(a)	468372 NM_001009117.1 NP_001009117.1
mouse (Mus musculus)	Ubb⁵	11 (35.00 cM)	ubiquitin B	--	X51703
chicken (Gallus gallus)	UBB¹	--	ubiquitin B	88.01(n) 100(a)	396190 XM_001233376.1 XP_001233377.1
fruit fly (Drosophila melanogaster)	Ubi-p63E³	3 63F5	response to heat protein degradation tagging	100(a) (best of 2)	--

About this table Species with no ortholog for UBB

ENSEMBL Gene Tree for UBB

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for UBB gene

UBA52² ENSG00000189251² UBC²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/14 NCBI SNPs in UBB are shown (see all 14 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 12)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1006958^1,2	C,F,H	16223179(+)	`GTTTCC/TGGTCC`	1	--	ng5¹		7		EU EA WA NA	536
--	rs4584862^1,2	A	16223407(+)	`atctcC/Ttgagc`	1	--	ng5¹		0	--	--	--	--
	rs3744326^1,2	H	16225146(-)	`ACAAAG/CCCAAC`	1	--	ut5¹		4		EU EA WA	410
--	rs57208572^1,2	--	16224135(+)	`TTTTTA/GTATTT`	1	--	ng5¹		0	--	--	--	--
--	rs60019048^1,2	--	16224147(+)	`TAGTAC/GAGACG`	1	--	ng5¹		0	--	--	--	--
--	rs56224145^1,2	--	16223684(+)	`GAACCA/CGGGAG`	1	--	ng5¹		0	--	--	--	--
--	rs9893057^1,2	--	16223850(+)	`tggagA/Gtcaag`	1	--	ng5¹		0	--	--	--	--
--	rs59858833^1,2	--	16224121(+)	`ACGCCC/TGGCTA`	1	--	ng5¹		0	--	--	--	--
--	rs62074226^1,2	--	16224385(+)	`CCGAGA/GCGGGT`	1	--	ng5¹		0	--	--	--	--
--	rs58452336^1,2	--	16224117(+)	`CACCAC/TGCCCG`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for UBB (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 191339 disorders: 119540

2 Novoseek disease relationships for UBB gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	56.06	8	11124436 (1), 10911966 (1), 10666673 (1), 15582744 (1) (see all 5)
down syndrome	48.74	1	10666673 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/125 PubMed articles for UBB gene (see all 125 ):

Lineage-specific homogenization of the polyubiquitin gene among human and great apes. (PubMed id 14745543)^{1, 3, 4} Tachikui H.... Inoue I. (2003)
Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12. (PubMed id 2154095)^{1, 2, 3} Webb G.C....Board P.G. (1990)
The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells. (PubMed id 17203973)^{3, 4} Vasilescu J.... Figeys D. (2007)
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domain. (PubMed id 16543144)^{3, 4} Huang F.... Sorkin A. (2006)
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. (PubMed id 16443603)^{3, 4} Cripps D.... Yang A.J. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis. (PubMed id 15466860)^{3, 4} Okumura F.... Nakayama K. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde. (PubMed id 12507430)^{3, 4} Hu M....Shi Y. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7314	HGNC: 12463	AceView: UBB	Ensembl:ENSG00000170315	euGenes: HUgn7314
ECgene: UBB	H-InvDB: UBB

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for UBB	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for UBB
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for UBB:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for UBB-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for UBB		Antibodies for UBB
	Explore super-pooled esiRNAs		Proteins for UBB
	Lentivirus-delivered shRNAs for UBB		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (UBB)
	Antibodies (UBB)
	Chimera RNAi (UBB)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Ubiquitin +1, Ubiquitin)
	Antibodies (Ubiquitin +1, Ubiquitin)

Search OriGene for UBB

Search Tocris compounds for UBB

	Proteins for UBB
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for UBB

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
UBB Gene at Home site.
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UBB Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for UBB

Summaries
for UBB

Genomic Location
for UBB

Proteins
for UBB

Protein Domains/
Families
for UBB

Gene Function
for UBB

Pathways & Interactions
for UBB

Drugs & Compounds
for UBB

Transcripts
for UBB

Expression
for UBB

Orthologs
for UBB

Paralogs
for UBB

SNPs/Variants
for UBB

Disorders & Mutations
for UBB

Medical News
for UBB

Publications
for UBB

Search for UBB

Genome Databases showing UBB

Other Databases showing UBB

Specialized Databases showing UBB

Licensable Technologies
for UBB

Services
for UBB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

UBB Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor UBB

Summariesfor UBB

Genomic Locationfor UBB

Proteinsfor UBB

Protein Domains/Familiesfor UBB

Gene Functionfor UBB

Pathways & Interactionsfor UBB

Drugs & Compoundsfor UBB

Transcriptsfor UBB

Expression for UBB

Orthologsfor UBB

Paralogsfor UBB

SNPs/Variantsfor UBB

Disorders & Mutationsfor UBB

Medical Newsfor UBB

Publicationsfor UBB

Search for UBB

Genome Databases showing UBB

Other Databases showing UBB

Specialized Databases showing UBB

Licensable Technologiesfor UBB

Servicesfor UBB

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for UBB

Summaries
for UBB

Genomic Location
for UBB

Proteins
for UBB

Protein Domains/
Families
for UBB

Gene Function
for UBB

Pathways & Interactions
for UBB

Drugs & Compounds
for UBB

Transcripts
for UBB

Expression
for UBB

Orthologs
for UBB

Paralogs
for UBB

SNPs/Variants
for UBB

Disorders & Mutations
for UBB

Medical News
for UBB

Publications
for UBB

Licensable Technologies
for UBB

Services
for UBB