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Aliases for UBASH3B Gene

Aliases for UBASH3B Gene

  • Ubiquitin Associated And SH3 Domain Containing B 2 3
  • Suppressor Of T-Cell Receptor Signaling 1 2 3 4
  • STS1 3 4 6
  • Tyrosine-Protein Phosphatase STS1/TULA2 3 4
  • Nm23-Phosphorylated Unknown Substrate 2 3
  • Cbl-Interacting Protein P70 3 4
  • T-Cell Ubiquitin Ligand 2 3 4
  • KIAA1959 4 6
  • TULA-2 3 4
  • STS-1 3 4
  • P70 3 6
  • SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling 1, Nm23-Phosphorylated Unknown Substrate 3
  • Ubiquitin-Associated And SH3 Domain-Containing Protein B 3
  • SH3 Domain-Containing 70 KDa Protein 2
  • Cbl-Interacting Protein Sts-1 3
  • EC 3.1.3.48 4
  • TULA2 3

External Ids for UBASH3B Gene

Summaries for UBASH3B Gene

Entrez Gene Summary for UBASH3B Gene

  • This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBASH3B Gene

UBASH3B (Ubiquitin Associated And SH3 Domain Containing B) is a Protein Coding gene. Diseases associated with UBASH3B include cat-scratch disease. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is UBASH3A.

UniProtKB/Swiss-Prot for UBASH3B Gene

  • Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Gene Wiki entry for UBASH3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBASH3B Gene

Genomics for UBASH3B Gene

Genomic Location for UBASH3B Gene

Start:
122,655,675 bp from pter
End:
122,814,479 bp from pter
Size:
158,805 bases
Orientation:
Plus strand

Genomic View for UBASH3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBASH3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBASH3B Gene

Regulatory Elements for UBASH3B Gene

Proteins for UBASH3B Gene

  • Protein details for UBASH3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF42-UBS3B_HUMAN
    Recommended name:
    Ubiquitin-associated and SH3 domain-containing protein B
    Protein Accession:
    Q8TF42
    Secondary Accessions:
    • Q53GT5
    • Q53GT8
    • Q8NBV7
    • Q96IG9
    • Q96NZ2

    Protein attributes for UBASH3B Gene

    Size:
    649 amino acids
    Molecular mass:
    72696 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins.
    SequenceCaution:
    • Sequence=AAL16953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85545.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBASH3B Gene

neXtProt entry for UBASH3B Gene

Proteomics data for UBASH3B Gene at MOPED

Post-translational modifications for UBASH3B Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys21, Lys112, Lys401, Lys411, Lys567, and Lys596

Other Protein References for UBASH3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBASH3B Gene

Domains for UBASH3B Gene

Suggested Antigen Peptide Sequences for UBASH3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF42

UniProtKB/Swiss-Prot:

UBS3B_HUMAN
Domain:
  • Contains 1 SH3 domain.:
    • Q8TF42
  • Contains 1 UBA domain.:
    • Q8TF42
genes like me logo Genes that share domains with UBASH3B: view

No data available for Gene Families for UBASH3B Gene

Function for UBASH3B Gene

Molecular function for UBASH3B Gene

UniProtKB/Swiss-Prot CatalyticActivity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Enzyme Numbers (IUBMB) for UBASH3B Gene

Gene Ontology (GO) - Molecular Function for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 20585042
genes like me logo Genes that share ontologies with UBASH3B: view

miRNA for UBASH3B Gene

miRTarBase miRNAs that target UBASH3B

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for UBASH3B Gene

Localization for UBASH3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBASH3B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBASH3B Gene COMPARTMENTS Subcellular localization image for UBASH3B gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBASH3B: view

Pathways for UBASH3B Gene

SuperPathways for UBASH3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0051279 regulation of release of sequestered calcium ion into cytosol IEA --
GO:0090331 negative regulation of platelet aggregation IEA --
genes like me logo Genes that share ontologies with UBASH3B: view

No data available for Pathways by source for UBASH3B Gene

Compounds for UBASH3B Gene

(5) Novoseek inferred chemical compound relationships for UBASH3B Gene

Compound -log(P) Hits PubMed IDs
wortmannin 60.6 4
tyrosine 49.5 10
rapamycin 42.7 5
phosphatidylinositol 41.8 3
phosphoinositide 25.7 1
genes like me logo Genes that share compounds with UBASH3B: view

Transcripts for UBASH3B Gene

Unigene Clusters for UBASH3B Gene

Ubiquitin associated and SH3 domain containing B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - - - - - - - - -
SP9: - -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for UBASH3B Gene

GeneLoc Exon Structure for
UBASH3B
ECgene alternative splicing isoforms for
UBASH3B

Expression for UBASH3B Gene

mRNA expression in normal human tissues for UBASH3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBASH3B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (9.2), Brain - Cerebellum (7.8), and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBASH3B Gene

SOURCE GeneReport for Unigene cluster for UBASH3B Gene Hs.444075

genes like me logo Genes that share expressions with UBASH3B: view

No data available for mRNA Expression by UniProt/SwissProt for UBASH3B Gene

Orthologs for UBASH3B Gene

This gene was present in the common ancestor of animals.

Orthologs for UBASH3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBASH3B 35
  • 99.64 (n)
  • 99.85 (a)
UBASH3B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBASH3B 35
  • 90.86 (n)
  • 98 (a)
UBASH3B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBASH3B 35
  • 89.99 (n)
  • 94.81 (a)
UBASH3B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubash3b 35
  • 89.18 (n)
  • 97.65 (a)
Ubash3b 16
Ubash3b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBASH3B 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBASH3B 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubash3b 35
  • 87.88 (n)
  • 96.71 (a)
chicken
(Gallus gallus)
Aves UBASH3B 35
  • 80.44 (n)
  • 90.67 (a)
UBASH3B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBASH3B 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubash3b 35
  • 74.82 (n)
  • 83.86 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-49j11.1 35
  • 70.17 (n)
  • 74.88 (a)
UBASH3B (1 of 2) 36
  • 74 (a)
OneToMany
UBASH3B (2 of 2) 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002463 35
  • 50 (n)
  • 43.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13604 35
  • 49.54 (n)
  • 42.86 (a)
CG13604 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07F12.1 35
  • 48.64 (n)
  • 41.46 (a)
T07F12.1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
Species with no ortholog for UBASH3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBASH3B Gene

ENSEMBL:
Gene Tree for UBASH3B (if available)
TreeFam:
Gene Tree for UBASH3B (if available)

Paralogs for UBASH3B Gene

Paralogs for UBASH3B Gene

Selected SIMAP similar genes for UBASH3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBASH3B: view

Variants for UBASH3B Gene

Sequence variations from dbSNP and Humsavar for UBASH3B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2233 -- 122,713,899(-) CATCT(C/G)ATGGA intron-variant
rs2234 -- 122,713,967(-) TTCTG(G/T)GAGCC intron-variant
rs2361 -- 122,714,181(-) GCCCC(A/G)CTAAA intron-variant
rs2362 -- 122,714,172(-) AAGAA(A/G)CTGAT intron-variant
rs866904 -- 122,713,974(-) CTGAT(-/C)AGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBASH3B Gene

Variant ID Type Subtype PubMed ID
dgv169n27 CNV Loss 19166990
nsv527 CNV Insertion 18451855
esv9672 OTHER Inversion 19470904
nsv898433 CNV Gain 21882294

Relevant External Links for UBASH3B Gene

HapMap Linkage Disequilibrium report
UBASH3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBASH3B Gene

Disorders for UBASH3B Gene

(1) MalaCards Diseases for UBASH3B Gene

Search for UBASH3B Gene in MalaCards »

(1) University of Copenhagen DISEASES for UBASH3B Gene

(5) Novoseek inferred disease relationships for UBASH3B Gene

Disease -log(P) Hits PubMed IDs
myeloma 23.6 2
necrosis 9.26 2
tumors 0 2
lymphoma 0 2
tuberculosis 0 1

Relevant External Links for UBASH3B

Genetic Association Database (GAD)
UBASH3B
Human Genome Epidemiology (HuGE) Navigator
UBASH3B
genes like me logo Genes that share disorders with UBASH3B: view

No data available for UniProtKB/Swiss-Prot for UBASH3B Gene

Publications for UBASH3B Gene

  1. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PMID: 15159412) Kowanetz K. … Dikic I. (J. Biol. Chem. 2004) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4
  3. Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. (PMID: 12370296) Carpino N. … Ihle J.N. (Mol. Cell. Biol. 2002) 2 3
  4. Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. (PMID: 17880946) Raguz J. … Hoeller D. (FEBS Lett. 2007) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UBASH3B Gene

Sources for UBASH3B Gene

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