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UBASH3B Gene

protein-coding   GIFtS: 59
GCID: GC11P122526

Ubiquitin Associated And SH3 Domain Containing B

  See UBASH3B-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Associated And SH3 Domain Containing B1 2     KIAA19593 5
Suppressor Of T-Cell Receptor Signaling 11 2 3     SH3 Domain-Containing 70 KDa Protein1
STS12 3 5     Cbl-Interacting Protein Sts-12
Nm23-Phosphorylated Unknown Substrate1 2     p702
Cbl-Interacting Protein P702 3     SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor
Signaling 1, Nm23-Phosphorylated Unknown Substrate2
Tyrosine-Protein Phosphatase STS1/TULA22 3     Ubiquitin-Associated And SH3 Domain-Containing Protein B2
STS-12 3     EC 3.1.3.483
TULA-22 3     P705
T-Cell Ubiquitin Ligand 22 3     

External Ids:    HGNC: 298841   Entrez Gene: 849592   Ensembl: ENSG000001541277   OMIM: 6092015   UniProtKB: Q8TF423   

Export aliases for UBASH3B gene to outside databases

Previous GC identifers: GC11P122032 GC11P118468


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBASH3B Gene:
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a
C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was
found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor
receptor. (provided by RefSeq, Jul 2008)

GeneCards Summary for UBASH3B Gene:
UBASH3B (ubiquitin associated and SH3 domain containing B) is a protein-coding gene. Diseases associated with UBASH3B include cat-scratch disease. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is UBASH3A.

UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes
accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits
tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates
proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination

Gene Wiki entry for UBASH3B (STS-1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_033899.9  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBASH3B gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   E47   c-Ets-1   GATA-2   PPAR-gamma1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBASH3B promoter sequence
   Search Chromatin IP Primers for UBASH3B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBASH3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

UBASH3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBASH3B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P122526:  view genomic region     (about GC identifiers)

Start:
122,526,383 bp from pter      End:
122,685,187 bp from pter
Size:
158,805 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42 (See protein sequence)
Recommended Name: Ubiquitin-associated and SH3 domain-containing protein B  
Size: 649 amino acids; 72696 Da
Subunit: Homodimer (By similarity). Interacts with CBL. Part of a complex containing CBL and activated EGFR.
Interacts with ubiquitin and with mono-ubiquitinated proteins
Sequence caution: Sequence=AAL16953.1; Type=Erroneous initiation; Sequence=BAB85545.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for UBASH3B:
2CPW (3D)        2E5K (3D)    
Secondary accessions: Q53GT5 Q53GT8 Q8NBV7 Q96IG9 Q96NZ2

Explore the universe of human proteins at neXtProt for UBASH3B: NX_Q8TF42

Explore proteomics data for UBASH3B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys21, Lys112, Lys401, Lys411, Lys567, Lys596
  • Modification sites at PhosphoSitePlus

  • See UBASH3B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_116262.2  
    ENSEMBL proteins: 
     ENSP00000284273  

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    antibodies-online proteins for UBASH3B (5 products) 

     
    antibodies-online peptides for UBASH3B

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001452 SH3_domain
     IPR009060 UBA-like
     IPR000449 UBA/Ts_N
     IPR013078 His_Pase_superF_clade-1
     IPR015940 UBA/transl_elong_EF1B_N_euk

    Graphical View of Domain Structure for InterPro Entry Q8TF42

    ProtoNet protein and cluster: Q8TF42

    1 Blocks protein domain: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UBA domain


    Find genes that share domains with UBASH3B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBS3B_HUMAN, Q8TF42
    Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes
    accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits
    tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates
    proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

         Enzyme Number (IUBMB): EC 3.1.3.481

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004725protein tyrosine phosphatase activity IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with UBASH3B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for UBASH3B

    miRNA
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    miRTarBase miRNAs that target UBASH3B:
    hsa-mir-215-5p (MIRT024758), hsa-mir-192-5p (MIRT026942)

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    Selected qRT-PCR Assays for microRNAs that regulate UBASH3B (see all 102):
    hsa-miR-548j hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-3146 hsa-miR-106a hsa-miR-200a hsa-miR-219-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBS3B_HUMAN, Q8TF42: Cytoplasm (By similarity). Nucleus (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with UBASH3B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBASH3B
    Interactions:

        GeneGlobe Interaction Network for UBASH3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for UBASH3B (Q8TF421, 2, 3 ENSP000002842734) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434051, 2, 3, ENSP000003648984EBI-1380492,EBI-78302 MINT-8288555 MINT-8288567 I2D: score=1 STRING: ENSP00000364898
    PARK2O602602, 3, ENSP000003558654MINT-5208697 I2D: score=1 STRING: ENSP00000355865
    UBCP0CG482, 3, ENSP000003448184MINT-5208612 I2D: score=2 STRING: ENSP00000344818
    ARAP1Q96P483, ENSP000003772334I2D: score=1 STRING: ENSP00000377233
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity IEA--
    GO:0035335peptidyl-tyrosine dephosphorylation ----
    GO:0051279regulation of release of sequestered calcium ion into cytosol IEA--
    GO:0090331negative regulation of platelet aggregation IEA--

    Find genes that share ontologies with UBASH3B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBASH3B (UBS3B)

    5 Novoseek inferred chemical compound relationships for UBASH3B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wortmannin 60.6 6 9245714 (1), 7777579 (1), 9632736 (1), 9603962 (1)
    tyrosine 49.5 11 10965882 (2), 1845978 (2), 7852312 (2), 7629168 (1) (see all 7)
    rapamycin 42.7 9 9603962 (2), 9873051 (1), 11872747 (1), 9632736 (1)
    phosphatidylinositol 41.8 4 7777579 (3)
    phosphoinositide 25.7 1 12237112 (1)



    Find genes that share compounds with UBASH3B           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for UBASH3B gene: 
    NM_032873.4  

    Unigene Cluster for UBASH3B:

    Ubiquitin associated and SH3 domain containing B
    Hs.444075  [show with all ESTs]
    Unigene Representative Sequence: NM_032873
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284273(uc001pyi.4) ENST00000525711 ENST00000526386 ENST00000530917
    ENST00000533451 ENST00000529998 ENST00000526493 ENST00000530578
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    Selected qRT-PCR Assays for microRNAs that regulate UBASH3B (see all 102):
    hsa-miR-548j hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-3146 hsa-miR-106a hsa-miR-200a hsa-miR-219-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat UBASH3B
      QuantiFast Probe-based Assays in human, mouse, rat UBASH3B

    Additional mRNA sequence: 

    AB075839.1 AF425252.1 AK075203.1 AK092011.1 AK222843.1 AK222846.1 AL833092.2 BC007541.1 

    8 DOTS entries:

    DT.40123678  DT.97783522  DT.100781204  DT.100781206  DT.120738019  DT.75177197  DT.100781203  DT.95370044 

    Selected AceView cDNA sequences (see all 150):

    AB075839 BM464793 BG696863 AI654413 BQ925639 BM454467 AA628006 CA313832 
    AA464845 BF508750 AI361899 BU169816 BF590566 BU619553 AW574891 CA307610 
    BM802606 NM_032873 BG392397 AA040447 AK092011 AI291779 AK075203 BC007541 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:              -     -     -     -                 -                                                                             -                           
    SP2:                                                  -                                                                                                         
    SP3:              -     -     -     -     -     -     -                                                                                                         
    SP4:                          -     -                 -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 18
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for UBASH3B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBASH3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGGCATT
    UBASH3B Expression
    About this image


    UBASH3B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebellum
             Ventral/hypothalamic-like neurons
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             nGnG Amacrine Cells Inner Nuclear Layer
             Retina
     
     Neurons
             nGnG Amacrine Cells Inner Nuclear Layer
             Ventral/hypothalamic-like neurons
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Mesencephalic Floor Plate
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    UBASH3B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBASH3B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.444075
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBASH3B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UBASH3B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubash3b1 , 5 ubiquitin associated and SH3 domain containing, B1, 5 89.18(n)1
    97.65(a)1
      9 (21.84 cM)5
    728281  NM_176860.51  NP_789830.11 
     410110985 
    chicken
    (Gallus gallus)
    Aves UBASH3B1 ubiquitin associated and SH3 domain containing B 80.44(n)
    90.67(a)
      419748  XM_004948014.1  XP_004948071.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBASH3B6
    ubiquitin associated and SH3 domain containing B
    84(a)
    1 ↔ 1
    LGa(2861929-2889082)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia ubash3b1 ubiquitin associated and SH3 domain containing B 74.82(n)
    83.86(a)
      100125040  NM_001102961.1  NP_001096431.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-49j11.11 si:ch211-49j11.1 70.17(n)
    74.88(a)
      558545  XM_001923850.3  XP_001923885.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136041 CG13604 49.54(n)
    42.86(a)
      42840  NM_001275965.1  NP_001262894.1 
    worm
    (Caenorhabditis elegans)
    Secernentea T07F12.11 T07F12.1 48.64(n)
    41.46(a)
      188238  NM_076431.2  NP_508832.2 


    ENSEMBL Gene Tree for UBASH3B (if available)
    TreeFam Gene Tree for UBASH3B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBASH3B gene
    UBASH3A2  
    1 SIMAP similar gene for UBASH3B using alignment to 1 protein entry:     UBS3B_HUMAN:
    UBASH3A

    Find genes that share paralogs with UBASH3B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBASH3B (see all 3452)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501768031,2
    --122524413(+) AAGATA/TCTTGA 1 -- us2k10--------
    rs112187371,2
    C,F--122524581(+) CAAAGC/TGCTTT 1 -- us2k11Minor allele frequency- T:0.20NA 120
    rs1385698161,2
    --122524631(+) TGACTC/TTCAGC 1 -- us2k10--------
    rs619115021,2
    C,F--122524668(+) ACTGGA/GTAAAA 1 -- us2k13Minor allele frequency- G:0.14WA NA EA 358
    rs1145010351,2
    --122524719(+) TAGGTA/GTGGTG 1 -- us2k10--------
    rs619115031,2
    C--122524741(+) GTCTTG/ATCTTT 1 -- us2k13Minor allele frequency- A:0.13NA EA 242
    rs1173182411,2
    C,F--122524754(+) GCTCCA/GTGTCC 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs118280381,2
    H--122524917(+) TTCCAA/GACACC 1 -- us2k10--------
    rs112187381,2
    C,F,H--122524951(+) ATTCCG/AGGCTC 1 -- us2k120Minor allele frequency- A:0.16NS EA NA CSA WA 2342
    rs578124551,2
    C,F--122524967(+) GTTACA/GCTGTA 1 -- us2k13Minor allele frequency- G:0.21WA NA EA 358

    HapMap Linkage Disequilibrium report for UBASH3B (122526383 - 122685187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for UBASH3B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527CNV Insertion18451855
    dgv169n27CNV Loss19166990
    nsv898433CNV Gain21882294
    esv9672OTHER Inversion19470904

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBASH3B
    DNA2.0 Custom Variant and Variant Library Synthesis for UBASH3B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609201    OMIM disorders: --

    1 disease for UBASH3B:    
    About MalaCards
    cat-scratch disease

    1 disease from the University of Copenhagen DISEASES database for UBASH3B:
    cat-scratch disease

    Find genes that share disorders with UBASH3B           About GenesLikeMe

    5 Novoseek inferred disease relationships for UBASH3B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloma 23.6 2 11872747 (2)
    necrosis 9.26 2 8242620 (1), 15743872 (1)
    tumors 0 3 8242620 (1), 8159769 (1)
    lymphoma 0 2 11337356 (2)
    tuberculosis 0 1 16367946 (1)

    Genetic Association Database (GAD): UBASH3B
    Human Genome Epidemiology (HuGE) Navigator: UBASH3B (2 documents)

    Export disorders for UBASH3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBASH3B gene, integrated from 10 sources (see all 75):
    (articles sorted by number of sources associating them with UBASH3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PubMed id 15159412)1, 2, 9 Kowanetz K....Dikic I. (J. Biol. Chem. 2004)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. (PubMed id 17880946)1, 2 Raguz J.... Hoeller D. (FEBS Lett. 2007)
    5. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. (PubMed id 12370296)1, 3 Carpino N....Ihle J.N. (Mol. Cell. Biol. 2002)
    8. Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. (PubMed id 23784775)1 Lee S.T....Yu Q. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    9. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    10. Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation. (PubMed id 22267732)1 de Castro R.O....Siraganian R.P. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84959 HGNC: 29884 AceView: STS-1 Ensembl:ENSG00000154127 euGenes: HUgn84959
    ECgene: UBASH3B H-InvDB: UBASH3B

    (According to HUGE)
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    HUGE: KIAA1959

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UBASH3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UBASH3B gene:
    Search GeneIP for patents involving UBASH3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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