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Aliases for UBASH3B Gene

Aliases for UBASH3B Gene

  • Ubiquitin Associated And SH3 Domain Containing B 2 3 5
  • Suppressor Of T-Cell Receptor Signaling 1 2 3 4
  • Tyrosine-Protein Phosphatase STS1/TULA2 3 4
  • Nm23-Phosphorylated Unknown Substrate 2 3
  • Cbl-Interacting Protein P70 3 4
  • T-Cell Ubiquitin Ligand 2 3 4
  • TULA-2 3 4
  • STS-1 3 4
  • STS1 3 4
  • SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling 1, Nm23-Phosphorylated Unknown Substrate 3
  • SH3 Domain-Containing 70 KDa Protein 2
  • Cbl-Interacting Protein Sts-1 3
  • EC 3.1.3.48 4
  • KIAA1959 4
  • TULA2 3
  • P70 3

External Ids for UBASH3B Gene

Previous GeneCards Identifiers for UBASH3B Gene

  • GC11P122032
  • GC11P122526
  • GC11P118468

Summaries for UBASH3B Gene

Entrez Gene Summary for UBASH3B Gene

  • This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBASH3B Gene

UBASH3B (Ubiquitin Associated And SH3 Domain Containing B) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is UBASH3A.

UniProtKB/Swiss-Prot for UBASH3B Gene

  • Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Gene Wiki entry for UBASH3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBASH3B Gene

Genomics for UBASH3B Gene

Regulatory Elements for UBASH3B Gene

Enhancers for UBASH3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBASH3B on UCSC Golden Path with GeneCards custom track

Promoters for UBASH3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBASH3B on UCSC Golden Path with GeneCards custom track

Genomic Location for UBASH3B Gene

Chromosome:
11
Start:
122,655,675 bp from pter
End:
122,814,479 bp from pter
Size:
158,805 bases
Orientation:
Plus strand

Genomic View for UBASH3B Gene

Genes around UBASH3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBASH3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBASH3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBASH3B Gene

Proteins for UBASH3B Gene

  • Protein details for UBASH3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF42-UBS3B_HUMAN
    Recommended name:
    Ubiquitin-associated and SH3 domain-containing protein B
    Protein Accession:
    Q8TF42
    Secondary Accessions:
    • Q53GT5
    • Q53GT8
    • Q8NBV7
    • Q96IG9
    • Q96NZ2

    Protein attributes for UBASH3B Gene

    Size:
    649 amino acids
    Molecular mass:
    72696 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins.
    SequenceCaution:
    • Sequence=AAL16953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85545.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBASH3B Gene

neXtProt entry for UBASH3B Gene

Proteomics data for UBASH3B Gene at MOPED

Post-translational modifications for UBASH3B Gene

  • Ubiquitination at Lys 21, Lys 112, Lys 401, Lys 411, Lys 567, and Lys 596
  • Modification sites at PhosphoSitePlus

Other Protein References for UBASH3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for UBASH3B (UBASH3B/STS1)

No data available for DME Specific Peptides for UBASH3B Gene

Domains & Families for UBASH3B Gene

Gene Families for UBASH3B Gene

Protein Domains for UBASH3B Gene

Suggested Antigen Peptide Sequences for UBASH3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF42

UniProtKB/Swiss-Prot:

UBS3B_HUMAN :
  • Contains 1 SH3 domain.
Domain:
  • Contains 1 SH3 domain.
  • Contains 1 UBA domain.
genes like me logo Genes that share domains with UBASH3B: view

Function for UBASH3B Gene

Molecular function for UBASH3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Enzyme Numbers (IUBMB) for UBASH3B Gene

genes like me logo Genes that share phenotypes with UBASH3B: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBASH3B Gene

Localization for UBASH3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBASH3B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBASH3B Gene COMPARTMENTS Subcellular localization image for UBASH3B gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for UBASH3B Gene

Pathways & Interactions for UBASH3B Gene

SuperPathways for UBASH3B Gene

No Data Available

SIGNOR curated interactions for UBASH3B Gene

Inactivates:

Gene Ontology (GO) - Biological Process for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0045670 regulation of osteoclast differentiation IEA --
GO:0045671 negative regulation of osteoclast differentiation IEA --
GO:0051279 regulation of release of sequestered calcium ion into cytosol IEA --
genes like me logo Genes that share ontologies with UBASH3B: view

No data available for Pathways by source for UBASH3B Gene

Drugs & Compounds for UBASH3B Gene

(3) Drugs for UBASH3B Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for UBASH3B Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with UBASH3B: view

Transcripts for UBASH3B Gene

Unigene Clusters for UBASH3B Gene

Ubiquitin associated and SH3 domain containing B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - - - - - - - - -
SP9: - -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for UBASH3B Gene

GeneLoc Exon Structure for
UBASH3B
ECgene alternative splicing isoforms for
UBASH3B

Expression for UBASH3B Gene

mRNA expression in normal human tissues for UBASH3B Gene

mRNA differential expression in normal tissues according to GTEx for UBASH3B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.2), Brain - Cerebellum (x7.8), and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for UBASH3B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.4), Breast (18.7), and Platelet (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBASH3B Gene



SOURCE GeneReport for Unigene cluster for UBASH3B Gene Hs.444075

genes like me logo Genes that share expression patterns with UBASH3B: view

Protein tissue co-expression partners for UBASH3B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UBASH3B Gene

Orthologs for UBASH3B Gene

This gene was present in the common ancestor of animals.

Orthologs for UBASH3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBASH3B 35
  • 90.86 (n)
  • 98 (a)
UBASH3B 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBASH3B 35
  • 89.99 (n)
  • 94.81 (a)
UBASH3B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubash3b 35
  • 89.18 (n)
  • 97.65 (a)
Ubash3b 16
Ubash3b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBASH3B 35
  • 99.64 (n)
  • 99.85 (a)
UBASH3B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubash3b 35
  • 87.88 (n)
  • 96.71 (a)
oppossum
(Monodelphis domestica)
Mammalia UBASH3B 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBASH3B 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBASH3B 35
  • 80.44 (n)
  • 90.67 (a)
UBASH3B 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBASH3B 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubash3b 35
  • 74.82 (n)
  • 83.86 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-49j11.1 35
  • 70.17 (n)
  • 74.88 (a)
UBASH3B (1 of 2) 36
  • 74 (a)
OneToMany
UBASH3B (2 of 2) 36
  • 73 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002463 35
  • 50 (n)
  • 43.21 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13604 35
  • 49.54 (n)
  • 42.86 (a)
CG13604 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07F12.1 35
  • 48.64 (n)
  • 41.46 (a)
T07F12.1 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
ManyToMany
-- 36
  • 39 (a)
ManyToMany
Species with no ortholog for UBASH3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBASH3B Gene

ENSEMBL:
Gene Tree for UBASH3B (if available)
TreeFam:
Gene Tree for UBASH3B (if available)

Paralogs for UBASH3B Gene

Paralogs for UBASH3B Gene

(1) SIMAP similar genes for UBASH3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBASH3B: view

Variants for UBASH3B Gene

Sequence variations from dbSNP and Humsavar for UBASH3B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12790613 - 122,776,259(+) TTCAG(A/C/G)CAGCA reference, synonymous-codon, missense
rs35343548 - 122,808,070(+) AGGAA(A/G)TAACA reference, missense
rs866904 -- 122,713,974(-) CTGAT(-/C)AGTTC intron-variant
rs871843 -- 122,741,587(-) GACCC(A/G)CGAGG intron-variant
rs871844 -- 122,741,504(-) CTGAC(C/T)TAGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBASH3B Gene

Variant ID Type Subtype PubMed ID
dgv169n27 CNV Loss 19166990
nsv527 CNV Insertion 18451855
esv9672 OTHER Inversion 19470904
nsv898433 CNV Gain 21882294

Variation tolerance for UBASH3B Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.62; 86.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBASH3B Gene

HapMap Linkage Disequilibrium report
UBASH3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBASH3B Gene

Disorders for UBASH3B Gene

Relevant External Links for UBASH3B

Genetic Association Database (GAD)
UBASH3B
Human Genome Epidemiology (HuGE) Navigator
UBASH3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBASH3B

No disorders were found for UBASH3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBASH3B Gene

Publications for UBASH3B Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 67
  2. Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. (PMID: 23784775) Lee S.T. … Yu Q. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 3
  3. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PMID: 15159412) Kowanetz K. … Dikic I. (J. Biol. Chem. 2004) 3 23
  4. Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. (PMID: 12370296) Carpino N. … Ihle J.N. (Mol. Cell. Biol. 2002) 2 3
  5. Ubiquitin Receptor Protein UBASH3B Drives Aurora B Recruitment to Mitotic Microtubules. (PMID: 26766443) Krupina K. … Sumara I. (Dev. Cell 2016) 3

Products for UBASH3B Gene

Sources for UBASH3B Gene

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