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Aliases for UBASH3B Gene

Aliases for UBASH3B Gene

  • Ubiquitin Associated And SH3 Domain Containing B 2 3 5
  • T-Cell Ubiquitin Ligand 2 2 3 4
  • SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling 1, Nm23-Phosphorylated Unknown Substrate 2 3
  • Suppressor Of T-Cell Receptor Signaling 1 3 4
  • Tyrosine-Protein Phosphatase STS1/TULA2 3 4
  • Cbl-Interacting Protein P70 3 4
  • TULA-2 3 4
  • STS-1 3 4
  • STS1 3 4
  • Ubiquitin-Associated And SH3 Domain-Containing Protein B 3
  • Nm23-Phosphorylated Unknown Substrate 3
  • Cbl-Interacting Protein Sts-1 3
  • EC 3.1.3.48 4
  • KIAA1959 4
  • TULA2 3
  • P70 3

External Ids for UBASH3B Gene

Previous GeneCards Identifiers for UBASH3B Gene

  • GC11P122032
  • GC11P122526
  • GC11P118468

Summaries for UBASH3B Gene

Entrez Gene Summary for UBASH3B Gene

  • This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBASH3B Gene

UBASH3B (Ubiquitin Associated And SH3 Domain Containing B) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is UBASH3A.

UniProtKB/Swiss-Prot for UBASH3B Gene

  • Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Gene Wiki entry for UBASH3B Gene

Additional gene information for UBASH3B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBASH3B Gene

Genomics for UBASH3B Gene

Regulatory Elements for UBASH3B Gene

Enhancers for UBASH3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H122740 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +89.5 89534 9 HDGF PKNOX1 TBL1XR1 BMI1 BATF ZNF121 FOS ATF7 ETV6 RUNX3 CRTAM UBASH3B GC11M122744 ENSG00000239079
GH11H122695 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13.8 +42.6 42569 5 PKNOX1 HLF ZNF133 MAX BATF GATA3 POLR2A EGR1 FOS FOXP2 UBASH3B ENSG00000239079 GC11P122657
GH11H122654 1.5 FANTOM5 ENCODE dbSUPER 14.4 +0.7 735 2 ZFP64 ARID4B ZNF76 KLF17 SIN3A RAD21 ZNF2 YY1 GLIS2 SCRT2 UBASH3B GC11P122657
GH11H122713 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +60.5 60487 4 PKNOX1 ZFP64 MAX RELA SP1 POLR2A IKZF1 FOXP2 ATF7 RUNX3 UBASH3B ENSG00000239079 GC11P122657
GH11H122681 1 FANTOM5 ENCODE dbSUPER 17.9 +26.3 26286 1 POLR2A GLIS1 RAD21 MYC UBASH3B ENSG00000239079 ENSG00000255342 GC11P122657
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBASH3B on UCSC Golden Path with GeneCards custom track

Promoters for UBASH3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000046214 725 2001 ZFP64 ARID4B KLF17 SIN3A ZNF2 RAD21 YY1 GLIS2 SCRT2 ZNF391

Genomic Location for UBASH3B Gene

Chromosome:
11
Start:
122,655,675 bp from pter
End:
122,814,479 bp from pter
Size:
158,805 bases
Orientation:
Plus strand

Genomic View for UBASH3B Gene

Genes around UBASH3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBASH3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBASH3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBASH3B Gene

Proteins for UBASH3B Gene

  • Protein details for UBASH3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF42-UBS3B_HUMAN
    Recommended name:
    Ubiquitin-associated and SH3 domain-containing protein B
    Protein Accession:
    Q8TF42
    Secondary Accessions:
    • Q53GT5
    • Q53GT8
    • Q8NBV7
    • Q96IG9
    • Q96NZ2

    Protein attributes for UBASH3B Gene

    Size:
    649 amino acids
    Molecular mass:
    72696 Da
    Quaternary structure:
    • Homodimer. Interacts with JAK2 (in vitro) (By similarity). Interacts with CBL (PubMed:15159412). Part of a complex containing CBL and activated EGFR (PubMed:15159412). Interacts with ubiquitin and with mono-ubiquitinated proteins (PubMed:15159412). Interacts with ZAP70 (ubiquitinated form) (PubMed:26903241).
    SequenceCaution:
    • Sequence=AAL16953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85545.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBASH3B Gene

neXtProt entry for UBASH3B Gene

Post-translational modifications for UBASH3B Gene

  • Ubiquitination at posLast=2121, Lys112, posLast=401401, Lys411, posLast=567567, and Lys596
  • Modification sites at PhosphoSitePlus

Other Protein References for UBASH3B Gene

Antibody Products

  • R&D Systems Antibodies for UBASH3B (UBASH3B/STS1)
  • Abcam antibodies for UBASH3B
  • Santa Cruz Biotechnology (SCBT) Antibodies for UBASH3B

No data available for DME Specific Peptides for UBASH3B Gene

Domains & Families for UBASH3B Gene

Gene Families for UBASH3B Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UBASH3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBASH3B: view

No data available for UniProtKB/Swiss-Prot for UBASH3B Gene

Function for UBASH3B Gene

Molecular function for UBASH3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Enzyme Numbers (IUBMB) for UBASH3B Gene

Phenotypes From GWAS Catalog for UBASH3B Gene

Gene Ontology (GO) - Molecular Function for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 20585042
GO:0016787 hydrolase activity IEA --
GO:0031625 ubiquitin protein ligase binding IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with UBASH3B: view
genes like me logo Genes that share phenotypes with UBASH3B: view

Animal Models for UBASH3B Gene

MGI Knock Outs for UBASH3B:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBASH3B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBASH3B Gene

Localization for UBASH3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBASH3B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBASH3B gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBASH3B: view

Pathways & Interactions for UBASH3B Gene

SuperPathways for UBASH3B Gene

No Data Available

SIGNOR curated interactions for UBASH3B Gene

Inactivates:

Gene Ontology (GO) - Biological Process for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0030168 platelet activation IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with UBASH3B: view

No data available for Pathways by source for UBASH3B Gene

Drugs & Compounds for UBASH3B Gene

(5) Drugs for UBASH3B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for UBASH3B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBASH3B: view

Transcripts for UBASH3B Gene

Unigene Clusters for UBASH3B Gene

Ubiquitin associated and SH3 domain containing B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for UBASH3B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - - - - - - - - -
SP9: - -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for UBASH3B Gene

GeneLoc Exon Structure for
UBASH3B
ECgene alternative splicing isoforms for
UBASH3B

Expression for UBASH3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBASH3B Gene

mRNA differential expression in normal tissues according to GTEx for UBASH3B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.2), Brain - Cerebellum (x7.8), and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for UBASH3B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.4), Breast (18.7), and Platelet (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBASH3B Gene



Protein tissue co-expression partners for UBASH3B Gene

NURSA nuclear receptor signaling pathways regulating expression of UBASH3B Gene:

UBASH3B

SOURCE GeneReport for Unigene cluster for UBASH3B Gene:

Hs.444075

Evidence on tissue expression from TISSUES for UBASH3B Gene

  • Nervous system(4.7)
  • Blood(4.5)
  • Kidney(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with UBASH3B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBASH3B Gene

Orthologs for UBASH3B Gene

This gene was present in the common ancestor of animals.

Orthologs for UBASH3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBASH3B 33 34
  • 99.64 (n)
oppossum
(Monodelphis domestica)
Mammalia UBASH3B 34
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBASH3B 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBASH3B 33 34
  • 90.86 (n)
dog
(Canis familiaris)
Mammalia UBASH3B 33 34
  • 89.99 (n)
mouse
(Mus musculus)
Mammalia Ubash3b 33 16 34
  • 89.18 (n)
rat
(Rattus norvegicus)
Mammalia Ubash3b 33
  • 87.88 (n)
chicken
(Gallus gallus)
Aves UBASH3B 33 34
  • 80.44 (n)
lizard
(Anolis carolinensis)
Reptilia UBASH3B 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubash3b 33
  • 74.82 (n)
zebrafish
(Danio rerio)
Actinopterygii UBASH3B (1 of 2) 34
  • 74 (a)
OneToMany
UBASH3B (2 of 2) 34
  • 73 (a)
OneToMany
si:ch211-49j11.1 33
  • 70.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002463 33
  • 50 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13604 33 34
  • 49.54 (n)
worm
(Caenorhabditis elegans)
Secernentea T07F12.1 33 34
  • 48.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
ManyToMany
-- 34
  • 38 (a)
ManyToMany
Species where no ortholog for UBASH3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBASH3B Gene

ENSEMBL:
Gene Tree for UBASH3B (if available)
TreeFam:
Gene Tree for UBASH3B (if available)

Paralogs for UBASH3B Gene

Paralogs for UBASH3B Gene

(1) SIMAP similar genes for UBASH3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBASH3B: view

Variants for UBASH3B Gene

Sequence variations from dbSNP and Humsavar for UBASH3B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000001494 -- 122,675,379(+) GATGC(C/T)GTTCT intron-variant
rs1000031034 -- 122,750,625(+) TGCCT(G/T)CCTTG intron-variant
rs1000037359 -- 122,757,915(+) CACCA(A/T)GTTGA intron-variant
rs1000050593 -- 122,741,514(+) GTTCA(C/T)ATAGT intron-variant
rs1000077571 -- 122,678,917(+) CACTC(A/G)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBASH3B Gene

Variant ID Type Subtype PubMed ID
dgv169n27 CNV loss 19166990
dgv2187n54 CNV loss 21841781
esv3430463 CNV insertion 20981092
esv3627945 CNV loss 21293372
esv9672 OTHER inversion 19470904
nsv1039632 CNV gain 25217958
nsv1050579 CNV gain 25217958
nsv1053418 CNV gain 25217958
nsv527 CNV insertion 18451855
nsv952748 CNV duplication 24416366
nsv952749 CNV duplication 24416366
nsv972955 CNV duplication 23825009
nsv983212 CNV deletion 23825009

Variation tolerance for UBASH3B Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.62; 86.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBASH3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBASH3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBASH3B Gene

Disorders for UBASH3B Gene

Relevant External Links for UBASH3B

Genetic Association Database (GAD)
UBASH3B
Human Genome Epidemiology (HuGE) Navigator
UBASH3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBASH3B

No disorders were found for UBASH3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBASH3B Gene

Publications for UBASH3B Gene

  1. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PMID: 15159412) Kowanetz K … Dikic I (The Journal of biological chemistry 2004) 3 4 22 60
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4 60
  3. Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. (PMID: 23784775) Lee ST … Yu Q (Proceedings of the National Academy of Sciences of the United States of America 2013) 2 3 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. (PMID: 17880946) Raguz J … Hoeller D (FEBS letters 2007) 3 4 60

Products for UBASH3B Gene

Sources for UBASH3B Gene

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