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Aliases for UBASH3B Gene

Aliases for UBASH3B Gene

  • Ubiquitin Associated And SH3 Domain Containing B 2 3 5
  • SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling 1, Nm23-Phosphorylated Unknown Substrate 2 3
  • Suppressor Of T-Cell Receptor Signaling 1 3 4
  • Tyrosine-Protein Phosphatase STS1/TULA2 3 4
  • Cbl-Interacting Protein P70 3 4
  • T-Cell Ubiquitin Ligand 2 3 4
  • TULA-2 3 4
  • STS-1 3 4
  • STS1 3 4
  • Ubiquitin-Associated And SH3 Domain-Containing Protein B 3
  • Nm23-Phosphorylated Unknown Substrate 3
  • Cbl-Interacting Protein Sts-1 3
  • EC 3.1.3.48 4
  • KIAA1959 4
  • TULA2 3
  • P70 3

External Ids for UBASH3B Gene

Previous GeneCards Identifiers for UBASH3B Gene

  • GC11P122032
  • GC11P122526
  • GC11P118468

Summaries for UBASH3B Gene

Entrez Gene Summary for UBASH3B Gene

  • This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]

GeneCards Summary for UBASH3B Gene

UBASH3B (Ubiquitin Associated And SH3 Domain Containing B) is a Protein Coding gene. GO annotations related to this gene include protein tyrosine phosphatase activity. An important paralog of this gene is UBASH3A.

UniProtKB/Swiss-Prot for UBASH3B Gene

  • Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Gene Wiki entry for UBASH3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBASH3B Gene

Genomics for UBASH3B Gene

Regulatory Elements for UBASH3B Gene

Enhancers for UBASH3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F122632 0.8 Ensembl ENCODE 21.7 -23.1 -23141 0.9 NFE2 NFE2L2 UBASH3B ENSG00000239079 CRTAM ENSG00000254935
GH11F122681 1.3 FANTOM5 Ensembl ENCODE 17.9 +26.3 26286 1.4 CTCF RAD21 JUND POLR2A SMARCA4 GLIS1 MYC MAFK UBASH3B ENSG00000239079 ENSG00000255342 GC11P122657
GH11F122654 0.8 FANTOM5 ENCODE 14.4 +0.7 735 2.8 ZFP64 ZNF76 KLF17 ARID4B SIN3A ZNF2 GLIS2 SCRT2 ZNF391 EGR2 UBASH3B GC11P122657
GH11F122689 1.1 FANTOM5 Ensembl ENCODE 13.8 +39.6 39626 11.8 CTCF PKNOX1 ZNF133 SREBF2 TEAD4 MAX ZNF384 ZBTB40 GATA3 POLR2A UBASH3B ENSG00000239079 GC11P122657
GH11F122633 0.8 Ensembl ENCODE 13.4 -22.3 -22274 0.4 CTCF ZNF654 MAX SMC3 RAD21 UBASH3B ENSG00000239079 CRTAM ENSG00000255342 ENSG00000254935
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around UBASH3B on UCSC Golden Path with GeneCards custom track

Promoters for UBASH3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000570436 725 2001 ZFP64 KLF17 ARID4B SIN3A ZNF2 GLIS2 SCRT2 ZNF391 EGR2 ZNF263

Genomic Location for UBASH3B Gene

Chromosome:
11
Start:
122,655,675 bp from pter
End:
122,814,479 bp from pter
Size:
158,805 bases
Orientation:
Plus strand

Genomic View for UBASH3B Gene

Genes around UBASH3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBASH3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBASH3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBASH3B Gene

Proteins for UBASH3B Gene

  • Protein details for UBASH3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF42-UBS3B_HUMAN
    Recommended name:
    Ubiquitin-associated and SH3 domain-containing protein B
    Protein Accession:
    Q8TF42
    Secondary Accessions:
    • Q53GT5
    • Q53GT8
    • Q8NBV7
    • Q96IG9
    • Q96NZ2

    Protein attributes for UBASH3B Gene

    Size:
    649 amino acids
    Molecular mass:
    72696 Da
    Quaternary structure:
    • Homodimer (By similarity). Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins.
    SequenceCaution:
    • Sequence=AAL16953.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB85545.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for UBASH3B Gene

neXtProt entry for UBASH3B Gene

Post-translational modifications for UBASH3B Gene

  • Ubiquitination at Lys 21, Lys 112, Lys 401, Lys 411, Lys 567, and Lys 596
  • Modification sites at PhosphoSitePlus

Other Protein References for UBASH3B Gene

Antibody Products

  • R&D Systems Antibodies for UBASH3B (UBASH3B/STS1)
  • Abcam antibodies for UBASH3B
  • Santa Cruz Biotechnology (SCBT) Antibodies for UBASH3B

No data available for DME Specific Peptides for UBASH3B Gene

Domains & Families for UBASH3B Gene

Gene Families for UBASH3B Gene

Suggested Antigen Peptide Sequences for UBASH3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TF42

UniProtKB/Swiss-Prot:

UBS3B_HUMAN :
  • Contains 1 SH3 domain.
Domain:
  • Contains 1 SH3 domain.
  • Contains 1 UBA domain.
genes like me logo Genes that share domains with UBASH3B: view

Function for UBASH3B Gene

Molecular function for UBASH3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
UniProtKB/Swiss-Prot Function:
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Enzyme Numbers (IUBMB) for UBASH3B Gene

Gene Ontology (GO) - Molecular Function for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004725 protein tyrosine phosphatase activity IEA --
GO:0005515 protein binding IPI 20585042
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IPI 25416956
genes like me logo Genes that share ontologies with UBASH3B: view
genes like me logo Genes that share phenotypes with UBASH3B: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBASH3B Gene

Localization for UBASH3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBASH3B Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBASH3B Gene COMPARTMENTS Subcellular localization image for UBASH3B gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with UBASH3B: view

Pathways & Interactions for UBASH3B Gene

SuperPathways for UBASH3B Gene

No Data Available

SIGNOR curated interactions for UBASH3B Gene

Inactivates:

Gene Ontology (GO) - Biological Process for UBASH3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0009968 negative regulation of signal transduction IEA --
GO:0035335 peptidyl-tyrosine dephosphorylation IEA --
GO:0045670 regulation of osteoclast differentiation IEA --
GO:0045671 negative regulation of osteoclast differentiation IEA --
genes like me logo Genes that share ontologies with UBASH3B: view

No data available for Pathways by source for UBASH3B Gene

Drugs & Compounds for UBASH3B Gene

(5) Drugs for UBASH3B Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for UBASH3B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with UBASH3B: view

Transcripts for UBASH3B Gene

Unigene Clusters for UBASH3B Gene

Ubiquitin associated and SH3 domain containing B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - -
SP2: -
SP3: - - - - - - -
SP4: - - -
SP5:
SP6:
SP7:
SP8: - - - - - - - - - -
SP9: - -

ExUns: 18
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for UBASH3B Gene

GeneLoc Exon Structure for
UBASH3B
ECgene alternative splicing isoforms for
UBASH3B

Expression for UBASH3B Gene

mRNA expression in normal human tissues for UBASH3B Gene

mRNA differential expression in normal tissues according to GTEx for UBASH3B Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x9.2), Brain - Cerebellum (x7.8), and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for UBASH3B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.4), Breast (18.7), and Platelet (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBASH3B Gene



Protein tissue co-expression partners for UBASH3B Gene

NURSA nuclear receptor signaling pathways regulating expression of UBASH3B Gene:

UBASH3B

SOURCE GeneReport for Unigene cluster for UBASH3B Gene:

Hs.444075
genes like me logo Genes that share expression patterns with UBASH3B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UBASH3B Gene

Orthologs for UBASH3B Gene

This gene was present in the common ancestor of animals.

Orthologs for UBASH3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBASH3B 34 35
  • 99.64 (n)
oppossum
(Monodelphis domestica)
Mammalia UBASH3B 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBASH3B 35
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBASH3B 34 35
  • 90.86 (n)
dog
(Canis familiaris)
Mammalia UBASH3B 34 35
  • 89.99 (n)
mouse
(Mus musculus)
Mammalia Ubash3b 34 16 35
  • 89.18 (n)
rat
(Rattus norvegicus)
Mammalia Ubash3b 34
  • 87.88 (n)
chicken
(Gallus gallus)
Aves UBASH3B 34 35
  • 80.44 (n)
lizard
(Anolis carolinensis)
Reptilia UBASH3B 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubash3b 34
  • 74.82 (n)
zebrafish
(Danio rerio)
Actinopterygii UBASH3B (1 of 2) 35
  • 74 (a)
OneToMany
UBASH3B (2 of 2) 35
  • 73 (a)
OneToMany
si:ch211-49j11.1 34
  • 70.17 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002463 34
  • 50 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13604 34 35
  • 49.54 (n)
worm
(Caenorhabditis elegans)
Secernentea T07F12.1 34 35
  • 48.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 39 (a)
ManyToMany
-- 35
  • 38 (a)
ManyToMany
Species where no ortholog for UBASH3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for UBASH3B Gene

ENSEMBL:
Gene Tree for UBASH3B (if available)
TreeFam:
Gene Tree for UBASH3B (if available)

Paralogs for UBASH3B Gene

Paralogs for UBASH3B Gene

(1) SIMAP similar genes for UBASH3B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with UBASH3B: view

Variants for UBASH3B Gene

Sequence variations from dbSNP and Humsavar for UBASH3B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000722 -- 122,717,441(-) ACATC(C/T)TCCTC intron-variant
rs1000723 -- 122,715,993(+) CTTTG(G/T)CCCTG intron-variant
rs1008862 -- 122,686,190(-) TCCCA(A/G)ATAAT intron-variant
rs10219150 -- 122,718,964(+) CTCAG(C/G)AGGCT intron-variant
rs10219151 -- 122,719,200(+) ccacg(A/C/T)ggcta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBASH3B Gene

Variant ID Type Subtype PubMed ID
dgv169n27 CNV loss 19166990
dgv2187n54 CNV loss 21841781
esv3430463 CNV insertion 20981092
esv3627945 CNV loss 21293372
esv9672 OTHER inversion 19470904
nsv1039632 CNV gain 25217958
nsv1050579 CNV gain 25217958
nsv1053418 CNV gain 25217958
nsv527 CNV insertion 18451855
nsv952748 CNV duplication 24416366
nsv952749 CNV duplication 24416366
nsv972955 CNV duplication 23825009
nsv983212 CNV deletion 23825009

Variation tolerance for UBASH3B Gene

Residual Variation Intolerance Score: 31.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.62; 86.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBASH3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBASH3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBASH3B Gene

Disorders for UBASH3B Gene

Relevant External Links for UBASH3B

Genetic Association Database (GAD)
UBASH3B
Human Genome Epidemiology (HuGE) Navigator
UBASH3B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBASH3B

No disorders were found for UBASH3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBASH3B Gene

Publications for UBASH3B Gene

  1. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PMID: 15159412) Kowanetz K. … Dikic I. (J. Biol. Chem. 2004) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  3. Protein tyrosine phosphatase UBASH3B is overexpressed in triple-negative breast cancer and promotes invasion and metastasis. (PMID: 23784775) Lee S.T. … Yu Q. (Proc. Natl. Acad. Sci. U.S.A. 2013) 2 3 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. (PMID: 17880946) Raguz J. … Hoeller D. (FEBS Lett. 2007) 3 4 64

Products for UBASH3B Gene

Sources for UBASH3B Gene

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