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Aliases & Descriptions for UBASH3B
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| KIAA1959 1, 2, 3, 5 | | MGC15437 2 | | P70 5 | | STS-1 1, 2, 3 | | STS1 2, 3, 5 | | p70 2 |
| | | Descriptions |
|---|
| Cbl-interacting protein Sts-1 2 | | Cbl-interacting protein p70 3 | SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate 2 | | Suppressor of T-cell receptor signaling 1 2, 3 | | nm23-phosphorylated unknown substrate 2 | | ubiquitin associated and SH3 domain containing, B 2 |
|
| | Search outside databases for aliases for UBASH3B gene |
Summaries for UBASH3B(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for UBASH3B: This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq] UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surfaceGene Wiki entry for UBASH3B (STS-1) |
Genomic Location for UBASH3B
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q24.1 Ensembl cytogenetic band: 11q24.1 HGNC cytogenetic band: 11q24.1UBASH3B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P122032:
(about GC identifiers)
Start:
|
122,031,640 bp from pter |
End:
|
122,190,391 bp from pter |
Size:
|
158,752 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033899.7
| Proteins for UBASH3B
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42 (See
protein sequence)Recommended Name: Ubiquitin-associated and SH3 domain-containing protein B Size: 649 amino acids; 72696 Da
Subunit: Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins
Subcellular location: Cytoplasm (By similarity). Nucleus (Potential)
PDB structure from and Proteopedia :2CPW (3D)
 2E5K (3D)
 
Secondary accessions: Q53GT5 Q53GT8 Q8NBV7 Q96IG9 Q96NZ2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_116262.2
ENSEMBL proteins: ENSP00000284273
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for UBASH3B: Assays for UBASH3B: | Protein
Domains/ Families for UBASH3B(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8TF42
ProtoNet protein and cluster: Q8TF42 1 Blocks protein family: IPB001452 SH3 domain signature
UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42Similarity: Contains 1 SH3 domainSimilarity: Contains 1 UBA domain | Gene Function for UBASH3B
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032873
Applied Biosystems Silencer® siRNAs for UBASH3B
Sigma-Aldrich siRNA and siRNA Panels for UBASH3B  Sigma-Aldrich shRNA for UBASH3B  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_032873                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032873                                  untagged cDNA clone in CMV expression vector: NM_032873 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032873
UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface | Pathways & Interactions for UBASH3B
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for UBASH3B 
5/11 Interacting proteins for UBASH3B (ENSP000002842733 Q8TF422) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
|
Drugs & Compounds for UBASH3B(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBASH3B 4 Novoseek chemical compound relationships for UBASH3B gene
About this table
|
Transcripts for UBASH3B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032873
Sigma-Aldrich siRNA and siRNA Panels for UBASH3B  Sigma-Aldrich shRNA for UBASH3B  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_032873 REFSEQ mRNAs for UBASH3B gene: NM_032873.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_032873               OriGene GFP tagged cDNA clone in CMV expression vector: NM_032873                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_032873                                  untagged cDNA clone in CMV expression vector: NM_032873  Additional cDNA sequence: AB075839.1 AF425252.1 AK075203.1 AK092011.1 AK222843.1 AK222846.1 AL833092.2 BC007541.1 8 DOTS entries: DT.40123678 DT.97783522 DT.100781204 DT.100781206 DT.120738019 DT.75177197 DT.100781203 DT.95370044 24/150 AceView cDNA sequences (see all 150
):BQ925639 CA313832 AA464845 BG696863 AK075203 BF508750 AW574891 AI654413 BU620007 AI291779 BF590566 AK092011 BU191886 BU619553 AA628006 BM542343 BG392397 BM454467 CA307610 BM802606 BU169816 BM464793 AB075839 AI361899 Unigene Cluster for UBASH3B: Ubiquitin associated and SH3 domain containing, B Hs.444075 [show with all ESTs]Unigene Representative Sequence: NM_032873
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B (see all 9
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | ^ | 9a | · | 9b | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | |
| SP1: | |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBASH3B
1 Ensembl transcript including schematic representation: ENST00000284273
|
Expression for UBASH3B
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBASH3B expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBASH3B
1 / 2 13 probe-sets matching UBASH3B gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCAAGGCATT
SOURCE GeneReport for Unigene cluster: Hs.444075
|
Orthologs for UBASH3B
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBASH3B gene from 5/7 species (see all 7
)
About this table Species with no ortholog for UBASH3B
ENSEMBL Gene Tree for UBASH3B | Paralogs for UBASH3B(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBASH3B gene
- UBASH3A2
|
SNPs/Variants for UBASH3B(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBASH3B (up to first 250kb)
|
Disorders & Mutations for UBASH3B
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609201
5 Novoseek disease relationships for UBASH3B gene
About this table
Human Genome Epidemiology Navigator: UBASH3B (1 document)
|
Medical News for UBASH3B(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBASH3B (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/54 PubMed articles for UBASH3B gene (see all 54
):- Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)2, 3, 4 Nagase T....Ohara O. (2001)
- Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PubMed id 15159412)1, 3, 4 Kowanetz K....Dikic I. (2004)
- Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PubMed id 16303743)3, 4 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. (PubMed id 12370296)2, 3 Carpino N....Ihle J.N. (2002)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- TULA proteins regulate activity of the protein tyrosine kinase Syk. (PubMed id 18189269)3 Agrawal R....Tsygankov A. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Regulation of ubiquitin-binding proteins by monoubiquitination. (PubMed id 16429130)3 Hoeller D....Dikic I. (2006)
- Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. (PubMed id 15388581)3 Guo F....Bhalla K. (2005)
|
Search for UBASH3B
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBASH3B
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBASH3B
(According to HUGE)
About This Section
| |
Specialized Databases showing UBASH3B(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBASH3B(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBASH3B:

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Incremental update: 13 Oct 2009
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