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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBASH3B Gene

protein-coding   GIFtS: 54
GCID: GC11P122526

ubiquitin associated and SH3 domain containing B
 Explore 17 diseases affiliated with
UBASH3B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UBASH3B    

Aliases
for UBASH3B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ubiquitin Associated And SH3 Domain Containing B1 2     T-Cell Ubiquitin Ligand 22 3
STS-11 2 3     Cbl-Interacting Protein Sts-12
KIAA19591 3 5     Nm23-Phosphorylated Unknown Substrate2
STS12 3 5     P705
Cbl-Interacting Protein P702 3     SH3 Domain-Containing 70 KDa Protein, Suppressor Of T-Cell Receptor Signaling
1, Nm23-Phosphorylated Unknown Substrate2
Suppressor Of T-Cell Receptor Signaling 12 3     Ubiquitin-Associated And SH3 Domain-Containing Protein B2
Tyrosine-Protein Phosphatase STS1/TULA22 3     EC 3.1.3.483
TULA-22 3     P705

External Ids:    HGNC: 298841   Entrez Gene: 849592   Ensembl: ENSG000001541277   OMIM: 6092015   UniProtKB: Q8TF423   

Export aliases for UBASH3B gene to outside databases

Previous GC identifers: GC11P122032 GC11P118468


Summaries
for UBASH3B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UBASH3B:
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a
C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found
to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes
accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine
phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are
dually modified by both protein tyrosine phosphorylation and ubiquitination

Gene Wiki entry for UBASH3B (STS-1)


Genomic Views
for UBASH3B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBASH3B gene promoter:
         E2F-3a   E2F-4   E2F-5   E2F-2   E47   c-Ets-1   GATA-2   PPAR-gamma1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBASH3B promoter sequence
   Search SABiosciences Chromatin IP Primers for UBASH3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBASH3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

UBASH3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBASH3B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P122526:  view genomic region     (about GC identifiers)

Start:
 122,526,383 bp from pter      End:
 122,685,187 bp from pter
Size:
 158,805 bases      Orientation:
 plus strand

Proteins
for UBASH3B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42 (See protein sequence)
Recommended Name: Ubiquitin-associated and SH3 domain-containing protein B  
Size: 649 amino acids; 72696 Da
Subunit: Homodimer (By similarity). Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts
with ubiquitin and with mono-ubiquitinated proteins
Subcellular location: Cytoplasm (By similarity). Nucleus (Potential)
Sequence caution: Sequence=AAL16953.1; Type=Erroneous initiation; Sequence=BAB85545.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for UBASH3B:
2CPW (3D)        2E5K (3D)    
Secondary accessions: Q53GT5 Q53GT8 Q8NBV7 Q96IG9 Q96NZ2

Explore the universe of human proteins at neXtProt for UBASH3B: NX_Q8TF42

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8TF42

    • UBASH3B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116262.2  
    ENSEMBL proteins: 
     ENSP00000284273  

    Human Recombinant Protein Products: 
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    Novus Biologicals UBASH3B Proteins
    Novus Biologicals UBASH3B Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for UBASH3B

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    UBASH3B for ontologies           About GeneDecksing



    UBASH3B Antibody Products: 
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    Uscn ELISAs and CLIAs for UBASH3B

    Protein Domains /
    Families
    for UBASH3B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UBASH3B for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000449 UBA/transl_elong_EF1B_N
     IPR013078 His_Pase_superF_clade-1
     IPR001452 SH3_domain
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry Q8TF42

    ProtoNet protein and cluster: Q8TF42

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UBA domain


    Function
    for UBASH3B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42
    Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes
    accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine
    phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are
    dually modified by both protein tyrosine phosphorylation and ubiquitination
    Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate

    Enzyme Number (IUBMB): EC 3.1.3.481

    miRNA
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    8/102 QIAGEN miScript miRNA Assays for microRNAs that regulate UBASH3B (see all 102):
    hsa-miR-548j hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-3146 hsa-miR-106a hsa-miR-200a hsa-miR-219-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: UBASH3B
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for UBASH3B

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004725protein tyrosine phosphatase activity IEA--


    UBASH3B for ontologies           About GeneDecksing



    Pathways & Interactions
    for UBASH3B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBASH3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/33 Interacting proteins for UBASH3B (Q8TF422, 3 ENSP000002842734) via UniProtKB, MINT, STRING, and/or I2D (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SYKP434052, 3, ENSP000003648984MINT-8288555 MINT-8288567 I2D: score=1 STRING: ENSP00000364898
    PARK2O602602, 3, ENSP000003558654MINT-5208697 I2D: score=1 STRING: ENSP00000355865
    UBCP0CG482, 3, ENSP000003448184MINT-5208612 I2D: score=2 STRING: ENSP00000344818
    ARAP1Q96P483, ENSP000003772334I2D: score=1 STRING: ENSP00000377233
    CRKP461083, ENSP000003005744I2D: score=1 STRING: ENSP00000300574
    About this table

    Drugs & Compounds
    for UBASH3B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    UBASH3B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBASH3B
    5 Novoseek chemical compound relationships for UBASH3B gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wortmannin 60.6 6 9245714 (1), 7777579 (1), 9632736 (1), 9603962 (1)
    tyrosine 49.5 11 10965882 (2), 1845978 (2), 7852312 (2), 7629168 (1) (see all 7)
    rapamycin 42.7 9 9603962 (2), 9873051 (1), 11872747 (1), 9632736 (1)
    phosphatidylinositol 41.8 4 7777579 (3)
    phosphoinositide 25.7 1 12237112 (1)

    Search CenterWatch for drugs/clinical trials and news about UBASH3B / UBS3B 

    Transcripts
    for UBASH3B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UBASH3B gene: 
    NM_032873.4  

    Unigene Cluster for UBASH3B:

    Ubiquitin associated and SH3 domain containing B
    Hs.444075  [show with all ESTs]
    Unigene Representative Sequence: NM_032873
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284273(uc001pyi.4) ENST00000525711 ENST00000526386 ENST00000530917
    ENST00000533451 ENST00000529998 ENST00000526493 ENST00000530578

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBASH3B
    8/102 QIAGEN miScript miRNA Assays for microRNAs that regulate UBASH3B (see all 102):
    hsa-miR-548j hsa-miR-607 hsa-miR-520e hsa-miR-520f hsa-miR-3146 hsa-miR-106a hsa-miR-200a hsa-miR-219-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for UBASH3B
    OriGene shRNA RFP: UBASH3B
    OriGene siRNA: UBASH3B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat UBASH3B
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB075839.1 AF425252.1 AK075203.1 AK092011.1 AK222843.1 AK222846.1 AL833092.2 BC007541.1 

    8 DOTS entries:

    DT.40123678  DT.97783522  DT.100781204  DT.100781206  DT.120738019  DT.75177197  DT.100781203  DT.95370044 

    24/150 AceView cDNA sequences (see all 150):

    BU191886 AA323744 BU627084 BM542343 AI479069 BU620007 BC007541 CB158284 
    NM_032873 AA040447 BG392397 AK092011 AK075203 BM802606 AI291779 BM996244 
    AA464845 CA307610 AW574891 BM464793 BG696863 BF508750 BU169816 BQ925639 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:              -     -     -     -                 -                                                                             -                           
    SP2:                                                  -                                                                                                         
    SP3:              -     -     -     -     -     -     -                                                                                                         
    SP4:                          -     -                 -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 18
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for UBASH3B

    Expression
    for UBASH3B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBASH3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAAGGCATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UBASH3B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayernGnG Amacrine CellsAmacrine, Retina
    EyeRetinaEye
    Neural TubeDiencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 5 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Ventral/hypothalamic-like neurons (Generation of midbra...)
    Posterior foregut-like cells (A scalable, suspensi...)

    See UBASH3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBASH3B

    SOURCE GeneReport for Unigene cluster: Hs.444075
        SABiosciences Custom PCR Arrays for UBASH3B
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    In Situ
    Assay Products:     
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    Orthologs
    for UBASH3B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UBASH3B gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves UBASH3B1 ubiquitin associated and SH3 domain containing B 80.78(n)
    91.26(a)    		   419748  XM_417888.3  XP_417888.3 
    lizard
    (Anolis carolinensis)    		 Reptilia UBASH3B6
    		 --
    		 84(a)
    		 1 ↔ 1
    		 LGa(2861929-2889082)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5585451 ubiquitin associated and SH3 domain containing, A long more 70.07(n)
    74.88(a)    		   558545  XM_001923850.2  XP_001923885.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG136046
    		 --
    		 32(a)
    		 1 → many
    		 3R(19814528-19818638)
    worm
    (Caenorhabditis elegans)    		 Secernentea T07F12.16
    F09C12.86
    (see all 3)    		 Protein F09C12.8
    (see all 3)    		 35(a)
    26(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 X(4894031-4896161)
    II(5112715-5114146)


    ENSEMBL Gene Tree for UBASH3B (if available)
    TreeFam Gene Tree for UBASH3B (if available) 

    Paralogs
    for UBASH3B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBASH3B gene
    UBASH3A2  
    1 SIMAP similar gene for UBASH3B using alignment to 1 protein entry:     UBS3B_HUMAN:
    UBASH3A

    UBASH3B for paralogs           About GeneDecksing



    Genomic Variants
    for UBASH3B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2981 NCBI SNPs in UBASH3B are shown (see all 2981)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1501768031,2
    		--122524413(+) AAGATA/TCTTGA 1 -- us2k10--------
    rs112187371,2
    		C,F,--122524581(+) CAAAGC/TGCTTT 1 -- us2k11Minor allele frequency- T:0.20NA 120
    rs1385698161,2
    		--122524631(+) TGACTC/TTCAGC 1 -- us2k10--------
    rs619115021,2
    		C,F,--122524668(+) ACTGGA/GTAAAA 1 -- us2k13Minor allele frequency- G:0.14WA NA EA 358
    rs1145010351,2
    		--122524719(+) TAGGTA/GTGGTG 1 -- us2k10--------
    rs619115031,2
    		C,--122524741(+) GTCTTG/ATCTTT 1 -- us2k13Minor allele frequency- A:0.13NA EA 242
    rs1173182411,2
    		F,--122524754(+) GCTCCA/GTGTCC 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs118280381,2
    		H--122524917(+) TTCCAA/GACACC 1 -- us2k10--------
    rs112187381,2
    		C,F,H,--122524951(+) ATTCCG/AGGCTC 1 -- us2k120Minor allele frequency- A:0.16NS EA NA CSA WA 2342
    rs578124551,2
    		C,F,--122524967(+) GTTACA/GCTGTA 1 -- us2k13Minor allele frequency- G:0.21WA NA EA 358

    HapMap Linkage Disequilibrium report for UBASH3B (122526383 - 122685187 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for UBASH3B
         1 CNV: 53452
         1 Inversion: 59702

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    Disorders / Diseases
    for UBASH3B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UBASH3B for disorders           About GeneDecksing

    OMIM gene information: 609201    OMIM disorders: --

    17 diseases for UBASH3B:    About MalaCards
    cat-scratch disease    squamous cell carcinoma of the head and neck    squamous cell carcinoma    tuberous sclerosis
    herpes simplex    insulin resistance    multiple myeloma    multiple sclerosis
    myeloma    dermatomyositis    myeloid leukemia    acute leukemia
    tuberculosis    leukemia    carcinoma    immunodeficiency
    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for UBASH3B:
    cat-scratch disease

    5 Novoseek disease relationships for UBASH3B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloma 23.6 2 11872747 (2)
    necrosis 9.26 2 8242620 (1), 15743872 (1)
    tumors 0 3 8242620 (1), 8159769 (1)
    lymphoma 0 2 11337356 (2)
    tuberculosis 0 1 16367946 (1)

    Human Genome Epidemiology (HuGE) Navigator: UBASH3B (2 documents)

    Export disorders for UBASH3B gene to outside databases

    Publications
    for UBASH3B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBASH3B gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with UBASH3B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2, 3 Nagase T.... Ohara O. (2001)
    2. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PubMed id 15159412)1, 2, 9 Kowanetz K....Dikic I. (2004)
    3. Suppressor of T-cell receptor signalling 1 and 2 differentially regulate endocytosis and signalling of receptor tyrosine kinases. (PubMed id 17880946)1, 2 Raguz J.... Hoeller D. (2007)
    4. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein. (PubMed id 12370296)1, 3 Carpino N....Ihle J.N. (2002)
    7. Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation. (PubMed id 22267732)1 de Castro R.O....Siraganian R.P. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Comprehensive analysis of interactions between the Src -associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome. (PubMed id 22745667)1 Asbach B....Wagner R. (2012)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for UBASH3B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing UBASH3B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84959 HGNC: 29884 AceView: STS-1 Ensembl:ENSG00000154127 euGenes: HUgn84959
    ECgene: UBASH3B H-InvDB: UBASH3B

    Other Databases showing UBASH3B gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1959

    Specialized Databases showing UBASH3B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBASH3B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UBASH3B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UBASH3B gene:
    Search GeneIP for patents involving UBASH3B

    GeneCards and IP:
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