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UBASH3B Gene

protein-coding   GIFtS: 57

GC11P122032
ubiquitin associated and SH3 domain containing, B
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
KIAA1959 1, 2, 3, 5
MGC15437 2
P70 5
STS-1 1, 2, 3
STS1 2, 3, 5
p70 2
Descriptions
Cbl-interacting protein Sts-1 2
Cbl-interacting protein p70 3
SH3 domain-containing 70 kDa protein, suppressor of T-cell
receptor signaling 1, nm23-phosphorylated unknown
substrate 2
Suppressor of T-cell receptor signaling 1 2, 3
nm23-phosphorylated unknown substrate 2
ubiquitin associated and SH3 domain containing, B 2
External Ids
HGNC: 298841
Entrez Gene: 849592
UniProtKB: Q8TF423
Ensembl: ENSG000001541277
Search outside databases for aliases for UBASH3B gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for UBASH3B:
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3
domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate
mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor
(EGFR) and platelet-derived growth factor receptor. [provided by RefSeq]

UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine
kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR,
on the cell surface

Gene Wiki entry for UBASH3B (STS-1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

UBASH3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P122032:     (about GC identifiers)

Start:
122,031,640 bp from pter
End:
122,190,391 bp from pter
Size:
158,752 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000011.8  NT_033899.7  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42 (See protein sequence)
Recommended Name: Ubiquitin-associated and SH3 domain-containing protein B  
Size: 649 amino acids; 72696 Da
Subunit: Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with
ubiquitin and with mono-ubiquitinated proteins
Subcellular location: Cytoplasm (By similarity). Nucleus (Potential)
PDB structure from and Proteopedia :
2CPW (3D)    2E5K (3D)    
Secondary accessions: Q53GT5 Q53GT8 Q8NBV7 Q96IG9 Q96NZ2

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_116262.2  

    ENSEMBL proteins: 
    ENSP00000284273 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Sts1)
    Human Recombinant Proteins from Abnova (UBASH3B)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for UBASH3B: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Sts1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (UBASH3B)
    Novus Biologicals Antibodies for UBASH3B

    Assays for UBASH3B: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001452 SH3_domain
     IPR000449 UBA/transl_elong_EF1B_N
     IPR013078 PG_mutase
     IPR015940 UBA/transl_elong_EF1B_N_euk


       GeneDecks  UBASH3B for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q8TF42

    ProtoNet protein and cluster: Q8TF42

    1 Blocks protein family: IPB001452 SH3 domain signature

    UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UBA domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBASH3B)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032873

                  Applied Biosystems Silencer® siRNAs for UBASH3B

                  Sigma-Aldrich siRNA and siRNA Panels for UBASH3B  
                         Sigma-Aldrich shRNA for UBASH3B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for UBASH3B
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_032873
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_032873
                                     untagged cDNA clone in CMV expression vector: NM_032873 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_032873

    UniProtKB/Swiss-Prot: UBS3B_HUMAN, Q8TF42
    Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine
    kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR,
    on the cell surface

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  UBASH3B 


    5/11 Interacting proteins for UBASH3B (ENSP000002842733 Q8TF422) via UniProtKB, MINT, and/or STRING (see all 11 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCP629882STRING (score=.804) MINT-5208612
    PARK2O602602MINT-5208697
    RPS27AP629882MINT-5208612
    RPS27AP11P629882MINT-5208612
    RPS27AP12P629882MINT-5208612
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for UBASH3B
    4 Novoseek chemical compound relationships for UBASH3B gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    wortmannin 61.19 6 9245714 (1), 7777579 (1), 9632736 (1), 9603962 (1)
    tyrosine 50.24 11 10965882 (2), 1845978 (2), 7852312 (2), 7629168 (1) (see all 7)
    phosphatidylinositol 42.56 4 7777579 (3)
    phosphoinositide 26.67 1 12237112 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBASH3B)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_032873

                  Sigma-Aldrich siRNA and siRNA Panels for UBASH3B  
                         Sigma-Aldrich shRNA for UBASH3B  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_032873  

    REFSEQ mRNAs for UBASH3B gene: 

    NM_032873.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_032873  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_032873
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_032873
                                     untagged cDNA clone in CMV expression vector: NM_032873 

    Additional cDNA sequence: 

    AB075839.1 AF425252.1 AK075203.1 AK092011.1 AK222843.1 AK222846.1 AL833092.2 BC007541.1 

    8 DOTS entries:

    DT.40123678  DT.97783522  DT.100781204  DT.100781206  DT.120738019  DT.75177197  DT.100781203  DT.95370044 

    24/150 AceView cDNA sequences (see all 150 ):

    BQ925639 CA313832 AA464845 BG696863 AK075203 BF508750 AW574891 AI654413 
    BU620007 AI291779 BF590566 AK092011 BU191886 BU619553 AA628006 BM542343 
    BG392397 BM454467 CA307610 BM802606 BU169816 BM464793 AB075839 AI361899 

    Unigene Cluster for UBASH3B:

    Ubiquitin associated and SH3 domain containing, B
    Hs.444075  [show with all ESTs]
    Unigene Representative Sequence: NM_032873


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3B (see all 9 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:              -     -     -     -                 -                                                                             -                           
    SP2:                                                  -                                                                                                         
    SP3:              -     -     -     -     -     -     -                                                                                                         
    SP4:                          -     -                 -                                                                                                         
    SP5:                                                                                                                                                            

    ExUns: 18
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      

    About this scheme

    ECgene alternative splicing isoforms for UBASH3B

    1 Ensembl transcript including schematic representation:
    ENST00000284273  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    UBASH3B expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for UBASH3B

    1 / 2

    13 probe-sets matching UBASH3B gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    74067_at2 U95-E 1 1.00 1.00 0.92 0.98 -- -- -- -- --
    67722_at2 U95-E 1 1.00 1.00 0.95 0.97 -- -- -- -- --
    91710_at2 U95-D 1 1.00 1.00 0.90 1.23 -- -- -- -- --
    65034_at2 U95-C 1 1.00 1.00 0.92 1.19 -- -- -- -- --

    53689_at2 U95-B 1 1.00 1.00 0.80 0.67 -- -- -- -- --

    238587_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    238462_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    228359_at2 U133-B 1 1.00 1.00 -- -- -- -- -- -- --

    228353_x_at2 U133-B 19 1.00 0.91 -- -- -- -- -- -- --

    238587_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    238462_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    228359_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    228353_x_at2 U133Plus2 19 1.00 0.91 -- -- -- -- -- -- --
    GeneDecks  UBASH3B for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCAAGGCATT

    SOURCE GeneReport for Unigene cluster: Hs.444075
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for UBASH3B gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    UBASH3B1   -- ubiquitin associated and SH3 domain containing, B 91.92(n)
    97.81(a)
    489355  XM_546473.2  XP_546473.2 
    chimpanzee
    (Pan troglodytes)
    UBASH3B1   -- ubiquitin associated and SH3 domain containing, B 99.64(n)
    99.85(a)
    451627  XM_508828.2  XP_508828.2 
    cow
    (Bos taurus)
    UBASH3B1   -- similar to Ubiquitin associated and SH3 domain-containing more 90.86(n)
    98(a)
    523809  XM_864208.2  XP_869301.1 
    rat
    (Rattus norvegicus)
    Ubash3b1   -- ubiquitin associated and SH3 domain containing, B 87.88(n)
    96.71(a)
    315579  XM_236104.4  XP_236104.4 
    mouse
    (Mus musculus)
    Ubash3b1, 5 95
    ubiquitin associated and SH3 domain containing, B1, 5 89.18(n)1
    97.65(a)1
    728281  NM_176860.41  NP_789830.11 
     AB0756025  AI8476025  (see all 21)
    About this table        Species with no ortholog for UBASH3B

    ENSEMBL Gene Tree for UBASH3B
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for UBASH3B gene
    UBASH3A2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1074 NCBI SNPs in UBASH3B are shown (see all 1074 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 377)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 11 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs15401081,2
    A,C,F,H,O122185809(+) AACCAC/TACCAG 1 -- ut31 ese312Minor allele frequency- T:0.18MN EU EA WA NA 1162
    rs31344281,2
    A,C,F,H,O122187366(+) CATGAA/GAGGAT 1 -- ut31 ese311Minor allele frequency- G:0.40NA EU EA WA 974
    rs79409591,2
    A,C,F,H122189542(+) GAGGCA/GCTAGT 1 -- ut31 ese34Minor allele frequency- G:0.16EU EA WA 420
    rs79298031,2
    A,C,F,H122187313(+) CATCTA/GTGCTT 1 -- ut317Minor allele frequency- G:0.09NA EU EA WA 538
    rs19453941,2
    C,F,H,O122189807(+) GTAAAT/CGCAGA 1 -- ut31 ese316Minor allele frequency- C:0.16EU EA WA NA 1468
    rs71279781,2
    A,C,F,H122031711(+) CGCAGA/CGCTGG 1 -- ut51 ese36Minor allele frequency- C:0.26MN EA EU WA 774
    rs79450591,2
    A,C,F,H122190699(+) AATATA/CTTTCC 1 -- ng314Minor allele frequency- C:0.16EU EA WA 418
    rs31344301,2
    A,C,F,H122188592(+) CCTGAA/TAGCAT 1 -- ut31 ese34Minor allele frequency- T:0.39EU EA WA 406
    --
    rs108928711,2
    A,C,F,H122030518(+) cagtaT/Gaaaac 1 -- ng514Minor allele frequency- G:0.13EU EA WA 412
    rs19968411,2
    A,C,F,H122187321(-) TCAAAC/TGCAAG 1 -- ut31 ese34Minor allele frequency- T:0.28EU EA WA 404
    About this table

    HapMap Linkage Disequilibrium images for UBASH3B (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 609201

    5 Novoseek disease relationships for UBASH3B gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloma 24.37 2 11872747 (2)
    necrosis 10.28 2 8242620 (1), 15743872 (1)
    tuberculosis 0.00 1 16367946 (1)
    tumors 0.00 3 8242620 (1), 8159769 (1)
    lymphoma 0.00 2 11337356 (2)
    About this table

    Human Genome Epidemiology Navigator: UBASH3B (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/54 PubMed articles for UBASH3B gene (see all 54 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 84959 HGNC: 29884 AceView: STS-1 Ensembl:ENSG00000154127 euGenes: HUgn84959
    ECgene: UBASH3B H-InvDB: UBASH3B
    (According to HUGE)
    About This Section

    HUGE: KIAA1959
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for UBASH3B:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for UBASH3B Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for UBASH3B Browse small molecules at Sigma-Aldrich
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