Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBASH3A Gene

Aliases for UBASH3A Gene

  • Ubiquitin Associated And SH3 Domain Containing A 2 3
  • Suppressor Of T-Cell Receptor Signaling 2 3 4
  • Cbl-Interacting Protein 4 3 4
  • T-Cell Ubiquitin Ligand 1 3 4
  • TULA-1 3 4
  • CLIP4 3 4
  • STS-2 3 4
  • Ubiquitin-Associated And SH3 Domain-Containing Protein A 3
  • T-Cell Ubiquitin Ligand Protein 3
  • TULA 3
  • STS2 4

External Ids for UBASH3A Gene

Summaries for UBASH3A Gene

Entrez Gene Summary for UBASH3A Gene

  • This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for UBASH3A Gene

UBASH3A (Ubiquitin Associated And SH3 Domain Containing A) is a Protein Coding gene. An important paralog of this gene is UBASH3B.

UniProtKB/Swiss-Prot for UBASH3A Gene

  • Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Gene Wiki entry for UBASH3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBASH3A Gene

Genomics for UBASH3A Gene

Genomic Location for UBASH3A Gene

Start:
42,403,862 bp from pter
End:
42,447,712 bp from pter
Size:
43,851 bases
Orientation:
Plus strand

Genomic View for UBASH3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBASH3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBASH3A Gene

Regulatory Elements for UBASH3A Gene

Proteins for UBASH3A Gene

  • Protein details for UBASH3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57075-UBS3A_HUMAN
    Recommended name:
    Ubiquitin-associated and SH3 domain-containing protein A
    Protein Accession:
    P57075
    Secondary Accessions:
    • G5E9E4
    • Q6HA34
    • Q6HA35
    • Q6ISI6
    • Q6ISK3
    • Q6ISS9

    Protein attributes for UBASH3A Gene

    Size:
    661 amino acids
    Molecular mass:
    74123 Da
    Quaternary structure:
    • Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. Interacts with dynamin.

    Three dimensional structures from OCA and Proteopedia for UBASH3A Gene

    Alternative splice isoforms for UBASH3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBASH3A Gene

Proteomics data for UBASH3A Gene at MOPED

Post-translational modifications for UBASH3A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11, Lys240, Lys347, Lys413, Lys425, Lys445, Lys516, and Lys521

Other Protein References for UBASH3A Gene

No data available for DME Specific Peptides for UBASH3A Gene

Domains for UBASH3A Gene

UniProtKB/Swiss-Prot:

UBS3A_HUMAN
Domain:
  • Contains 1 SH3 domain.:
    • P57075
  • Contains 1 UBA domain.:
    • P57075
genes like me logo Genes that share domains with UBASH3A: view

No data available for Gene Families for UBASH3A Gene

Function for UBASH3A Gene

Molecular function for UBASH3A Gene

UniProtKB/Swiss-Prot Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Gene Ontology (GO) - Molecular Function for UBASH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with UBASH3A: view

Phenotypes for UBASH3A Gene

genes like me logo Genes that share phenotypes with UBASH3A: view

Animal Models for UBASH3A Gene

MGI Knock Outs for UBASH3A:

miRNA for UBASH3A Gene

miRTarBase miRNAs that target UBASH3A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for UBASH3A Gene

Localization for UBASH3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBASH3A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBASH3A Gene COMPARTMENTS Subcellular localization image for UBASH3A gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for UBASH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005829 cytosol IDA 16780588
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with UBASH3A: view

Pathways for UBASH3A Gene

SuperPathways for UBASH3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBASH3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001817 regulation of cytokine production IEA --
GO:0008152 metabolic process --
GO:0050860 negative regulation of T cell receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with UBASH3A: view

No data available for Pathways by source for UBASH3A Gene

Transcripts for UBASH3A Gene

Unigene Clusters for UBASH3A Gene

Ubiquitin associated and SH3 domain containing A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for UBASH3A Gene

GeneLoc Exon Structure for
UBASH3A
ECgene alternative splicing isoforms for
UBASH3A

Expression for UBASH3A Gene

mRNA expression in normal human tissues for UBASH3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBASH3A Gene

This gene is overexpressed in Whole Blood (16.8), Spleen (8.4), and Small Intestine - Terminal Ileum (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBASH3A Gene

SOURCE GeneReport for Unigene cluster for UBASH3A Gene Hs.473912

mRNA Expression by UniProt/SwissProt for UBASH3A Gene

P57075-UBS3A_HUMAN
Tissue specificity: Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
genes like me logo Genes that share expressions with UBASH3A: view

Orthologs for UBASH3A Gene

This gene was present in the common ancestor of animals.

Orthologs for UBASH3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBASH3A 36
  • 98.82 (n)
  • 98.39 (a)
UBASH3A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBASH3A 36
  • 83.65 (n)
  • 84.73 (a)
UBASH3A 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBASH3A 36
  • 85.64 (n)
  • 85.85 (a)
UBASH3A 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubash3a 36
  • 81.86 (n)
  • 83.31 (a)
Ubash3a 16
Ubash3a 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBASH3A 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBASH3A 37
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBASH3A 36
  • 68.28 (n)
  • 67.37 (a)
UBASH3A 37
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBASH3A 37
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13604 37
  • 29 (a)
OneToMany
CG13604 38
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea T07F12.1 37
  • 34 (a)
OneToMany
T07F12.1 38
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
Species with no ortholog for UBASH3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBASH3A Gene

ENSEMBL:
Gene Tree for UBASH3A (if available)
TreeFam:
Gene Tree for UBASH3A (if available)

Paralogs for UBASH3A Gene

Paralogs for UBASH3A Gene

Selected SIMAP similar genes for UBASH3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBASH3A: view

Variants for UBASH3A Gene

Sequence variations from dbSNP and Humsavar for UBASH3A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs4101 -- 42,435,358(+) GCTTC(C/T)ACGTG intron-variant
rs868092 -- 42,443,411(+) TGTCC(A/G)CAGGA reference, synonymous-codon, intron-variant, nc-transcript-variant
rs868492 -- 42,424,158(+) CCTAC(A/G)AGCCC intron-variant
rs876497 -- 42,421,796(-) AAATA(C/T)GTTCT intron-variant
rs876498 -- 42,421,718(-) TTAAG(C/T)AGCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBASH3A Gene

Variant ID Type Subtype PubMed ID
dgv4749n71 CNV Gain 21882294
nsv522001 CNV Gain 19592680
esv2723546 CNV Deletion 23290073
esv998022 CNV Gain 20482838
nsv459275 CNV Loss 19166990

Relevant External Links for UBASH3A Gene

HapMap Linkage Disequilibrium report
UBASH3A

Disorders for UBASH3A Gene

Relevant External Links for UBASH3A

Genetic Association Database (GAD)
UBASH3A
Human Genome Epidemiology (HuGE) Navigator
UBASH3A
genes like me logo Genes that share disorders with UBASH3A: view

No data available for UniProtKB/Swiss-Prot for UBASH3A Gene

Publications for UBASH3A Gene

  1. TULA proteins regulate activity of the protein tyrosine kinase Syk. (PMID: 18189269) Agrawal R. … Tsygankov A. (J. Cell. Biochem. 2008) 3 4 23
  2. Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains. (PMID: 11281453) Wattenhofer M. … Scott H.S. (Hum. Genet. 2001) 2 3 4
  3. TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. (PMID: 15107835) Feshchenko E.A. … Tsygankov A.Y. (Oncogene 2004) 3 4
  4. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PMID: 15159412) Kowanetz K. … Dikic I. (J. Biol. Chem. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UBASH3A Gene

Sources for UBASH3A Gene

Back to Top

Content