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Aliases & Descriptions for UBASH3A
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase , and/or 9 Nature :405,311-319 and CroW21)About This Section
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Aliases CLIP4 1 , 2 , 3 STS-2 1 , 2 , 3 STS2 3 TULA 1 , 2 , 3
Descriptions Cbl-interacting protein 4 3 Suppressor of T-cell receptor signaling 2 3 T-cell ubiquitin ligand 3 T-cell ubiquitin ligand protein 2 gene similar to UBA containing SH3 domain 9 ubiquitin associated and SH3 domain containing, A 2
Search outside databases for aliases for UBASH3A genePrevious GC identifers: GC21P040371 GC21P042718
Summaries for UBASH3A (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075 Function : Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosinekinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR andPDGFRB, on the cell surface
Gene Wiki entry for UBASH3A
Genomic Location for UBASH3A
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences , Whole Chromsome Sequence According to
Nature (Cited Here with Permission) :405,311-319 and CroW21)About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 21q22.3 Ensembl cytogenetic band: 21q22.3 HGNC cytogenetic band: 21q22.3 Nature(405: 311-319) cytogenetic band: 21q22.3 UBASH3A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
GC21P042697:
GeneLoc
Nature :405,311-319
Start:
42,697,088 bp from pter
29,371,350 bp from centromere
End:
42,740,843 bp from pter
29,415,100 bp from centromere
Size:
43,756 bases
43,751 bases
Orientation:
plus strand
plus strand
RefSeq DNA sequence: NC_000021.7 NT_030188.4 Proteins for UBASH3A
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075 (See
protein sequence )Recommended Name: Ubiquitin-associated and SH3 domain-containing protein A Size : 661 amino acids; 74123 Da
Subunit : Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL andactivated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins
Subcellular location : Cytoplasm. Nucleus
PDB structures from and Proteopedia : 2CRN (3D)
 
Secondary accessions : Q6HA34 Q6HA35 Q6ISI6 Q6ISK3 Q6ISS9Alternative splicing : 2 isoforms : P57075-1 P57075-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001001895.1 NP_061834.1 ENSEMBL proteins: ENSP00000381408 ENSP00000317327 ENSP00000291535 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for UBASH3A: Assays for UBASH3A:
Protein
Domains/ Families for UBASH3A(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P57075 ProtoNet protein and cluster: P57075
2 Blocks protein families : IPB001345 Phosphoglycerate/bisphosphoglycerate mutase IPB001452 SH3 domain signature UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075 Similarity : Contains 1 SH3 domainSimilarity : Contains 1 UBA domain
Gene Function for UBASH3A
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): BC028138 Applied Biosystems Silencer ® siRNAs for UBASH3A Sigma-Aldrich siRNA and siRNA Panels for UBASH3A Sigma-Aldrich shRNA Panels and shRNA for UBASH3A Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001001895                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001001895                                  untagged cDNA clones in CMV expression vector (see all 3 ): BC028138  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018961 UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075 Function : Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosinekinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR andPDGFRB, on the cell surface
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Ubash3a) : Pathways & Interactions for UBASH3A
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for UBASH3A 5/14 Interacting proteins for UBASH3A (P57075 2 ENSP00000317327 3 ) via UniProtKB, MINT, and/or STRING (see all 14
)About this table
Drugs & Compounds for UBASH3A (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for UBASH3A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): BC028138 Sigma-Aldrich siRNA and siRNA Panels for UBASH3A Sigma-Aldrich shRNA Panels and shRNA for UBASH3A Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001001895 NM_018961
REFSEQ mRNAs for UBASH3A gene (2 alternative transcripts): NM_001001895.1 NM_018961.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001001895 NM_018961
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001001895                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001001895                                  untagged cDNA clones in CMV expression vector (see all 3 ): BC028138  
Additional cDNA sequence: AF520809.1 AF521702.1 AJ277750.1 AK301279.1 AK308151.1 AK313367.1 BC028138.1 BC069357.1 BC069483.1 BC069511.1 BC069577.1
6 DOTS entries : DT.306606 DT.95363856 DT.101980504 DT.100694701 DT.121132784 DT.435981
24/30 AceView cDNA sequences (see all 30
):AI056645 NM_001001895 NM_018961 AF521702 AJ277750 BC069357 BC028138 AA355926 BC069483 BI907563 BC069577 BX328099 AJ003495 AF520809 BX105291 AA707211 BX443486 BC069511 AA355773 BX448943 BX448944 AJ003414 BP368078 AJ003492
highest scoring ESTs for UBASH3A :AJ003495 AA707211 AF520809 AF521702 AI056645 AJ003455 AJ003480 AJ003486 AJ277750 BC028138
Unigene Cluster for UBASH3A: Ubiquitin associated and SH3 domain containing, A Hs.473912 [show with all ESTs ] Unigene Representative Sequence: BC028138 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3A ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b SP1 :               -                                 SP2 :               -         -                         SP3 :   -   -           -                                 SP4 :           -     -                                 SP5 :                                              
About this scheme ECgene alternative splicing isoforms for UBASH3A 3 Ensembl transcripts including schematic representations : ENST00000398367
ENST00000319294
ENST00000291535
Expression for UBASH3A
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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UBASH3A expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for UBASH3A 1 / 2 / 3
3 probe-sets matching UBASH3A gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGCTTCTGTGSOURCE GeneReport for Unigene cluster: Hs.473912 UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075 Tissue specificity : Highest expression of UBASH3A in tissues belonging to the immune system,including spleen, peripheral blood leukocytes, thymus and bone marrow
Orthologs for UBASH3A
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for UBASH3A gene from 5/8 species (see all 8
)
About this table Species with no ortholog for UBASH3A ENSEMBL Gene Tree for UBASH3A Paralogs for UBASH3A (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for UBASH3A gene UBASH3B 2
SNPs/Variants for UBASH3A (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for UBASH3A (up to first 250kb)
Disorders & Mutations for UBASH3A
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 605736 1 PharmGKB disease relationship for UBASH3A gene About this table Human Genome Epidemiology Navigator: UBASH3A (2 documents)
Medical News for UBASH3A (Possibly Related Articles in
Doctor's Guide )
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--
Publications for UBASH3A (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/14 PubMed articles for UBASH3A gene (see all 14
): Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains. (PubMed id 11281453) 2, 3, 4 Wattenhofer M.... Scott H.S. (2001) Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PubMed id 15159412) 3, 4 Kowanetz K....Dikic I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. (PubMed id 15107835) 3, 4 Feshchenko E.A.... Tsygankov A.Y. (2004) TULA proteins regulate activity of the protein tyrosine kinase Syk. (PubMed id 18189269) 1, 3 Agrawal R....Tsygankov A. (2008) T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis. (PubMed id 17709377) 1, 3 Collingwood T.S....Tsygankov A.Y. (2007) Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. (PubMed id 18840781) 3 Grant S.F....Hakonarson H. (2009) TULA proteins bind to ABCE-1, a host factor of HIV-1 assembly, and inhibit HIV-1 biogenesis in a UBA-dependent fashion. (PubMed id 18006034) 3 Smirnova E.V....Tsygankov A.Y. (2008) Shared and distinct genetic variants in type 1 diabetes and celiac disease. (PubMed id 19073967) 3 Smyth D.J....Todd J.A. (2008) The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis. (PubMed id 17382318) 3 Bertelsen V....Madshus I.H. (2007)
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Genome Databases showing UBASH3A
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing UBASH3A
(According to HUGE )
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Specialized Databases showing UBASH3A (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for UBASH3A (Reagents available from Applied Biosystems , Antibodies and assays by Cell
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