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UBASH3A Gene

protein-coding   GIFtS: 58
GCID: GC21P043824

Ubiquitin Associated And SH3 Domain Containing A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, 15RNAdb, and/or 11Nature:405,311-319 and CroW21)
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Aliases
Ubiquitin Associated And SH3 Domain Containing A1 2     T-Cell Ubiquitin Ligand 12 3
Cbl-Interacting Protein 42 3     Gene Similar To UBA Containing SH3 Domain11
Suppressor Of T-Cell Receptor Signaling 22 3     TULA2
CLIP42 3     T-Cell Ubiquitin Ligand Protein2
STS-22 3     Ubiquitin-Associated And SH3 Domain-Containing Protein A2
TULA-12 3     STS23

External Ids:    HGNC: 124621   Entrez Gene: 533472   Ensembl: ENSG000001601857   OMIM: 6057365   UniProtKB: P570753   

Export aliases for UBASH3A gene to outside databases

Previous GC identifers: GC21P040371 GC21P042718 GC21P042697 GC21P029250


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for UBASH3A Gene:
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family
members can negatively regulate T-cell signaling. This family member can facilitate growth factor
withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing
factor. Alternative splicing of this gene results in multiple transcript variants. (provided by RefSeq, Aug 2011)

GeneCards Summary for UBASH3A Gene:
UBASH3A (ubiquitin associated and SH3 domain containing A) is a protein-coding gene. Diseases associated with UBASH3A include dirofilariasis, and erysipeloid. An important paralog of this gene is UBASH3B.

UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes
accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.
Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator
of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally
sequestering dynamin via its SH3 domain

Gene Wiki entry for UBASH3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
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RefSeq DNA sequence:
NC_000021.9  NT_011512.12  NC_018932.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBASH3A gene promoter:
         Nkx3-1   Nkx3-1 v4   GATA-3   Nkx3-1 v1   Nkx3-1 v2   POU2F1   POU2F1a   GCNF-1   Nkx3-1 v3   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBASH3A promoter sequence

   Search Chromatin IP Primers for UBASH3A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBASH3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
UBASH3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBASH3A gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P043824:   GeneLoc Nature:405,311-319
Start:
43,824,008 bp from pter       29,371,350 bp from centromere
End:
43,867,791 bp from pter 29,415,100 bp from centromere
Size:
43,784 bases 43,751 bases
Orientation:
plus strand plus strand

genomic clones: KB169B4 KB994G8


(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075 (See protein sequence)
Recommended Name: Ubiquitin-associated and SH3 domain-containing protein A  
Size: 661 amino acids; 74123 Da
Subunit: Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR.
Interacts with ubiquitin and with mono-ubiquitinated proteins. Interacts with dynamin
1 PDB 3D structure from and Proteopedia for UBASH3A:
2CRN (3D)    
Secondary accessions: G5E9E4 Q6HA34 Q6HA35 Q6ISI6 Q6ISK3 Q6ISS9
Alternative splicing: 3 isoforms:  P57075-1   P57075-2   P57075-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBASH3A: NX_P57075

Explore proteomics data for UBASH3A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys11, Lys240, Lys347, Lys413, Lys425, Lys445, Lys516, Lys521
  • Modification sites at PhosphoSitePlus

  • See UBASH3A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001895.1  NP_001230396.1  NP_061834.1  

    ENSEMBL proteins: 
     ENSP00000291535   ENSP00000317327   ENSP00000381408   ENSP00000407179  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001452 SH3_domain
     IPR009060 UBA-like
     IPR013078 His_Pase_superF_clade-1
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR009097 RNA_ligase/cNuc_Pdiesterase

    Graphical View of Domain Structure for InterPro Entry P57075

    ProtoNet protein and cluster: P57075

    2 Blocks protein domains:
    IPB001345 Phosphoglycerate/bisphosphoglycerate mutase
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UBA domain


    UBASH3A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: UBS3A_HUMAN, P57075
    Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes
    accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface.
    Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator
    of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally
    sequestering dynamin via its SH3 domain

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity IEA--
    GO:0005515protein binding ----
         
    UBASH3A for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubash3a):
     hematopoietic system  immune system  normal 

    UBASH3A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ubash3atm1Jni for UBASH3A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBASH3A
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    miRNA
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    miRTarBase miRNAs that target UBASH3A:
    hsa-mir-215-5p (MIRT024364), hsa-mir-192-5p (MIRT026491), hsa-mir-21-5p (MIRT030805)

    Block miRNA regulation of human, mouse, rat UBASH3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBASH3A (see all 9):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b hsa-miR-17 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidUBASH3A 3' UTR sequence
    Inhib. RNA
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    Sino Biological Human cDNA Clone for UBASH3A
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBASH3A


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    UBS3A_HUMAN, P57075: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IDA16780588

    UBASH3A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBASH3A
    Interactions:

        GeneGlobe Interaction Network for UBASH3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    Selected Interacting proteins for UBASH3A (P570752, 3 ENSP000003173274) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARK2O602602, 3, ENSP000003558654MINT-5208683 I2D: score=1 STRING: ENSP00000355865
    UBCP0CG482, 3, ENSP000003448184MINT-5208635 I2D: score=2 STRING: ENSP00000344818
    DNM1Q051932, 3, ENSP000003620144MINT-7213627 I2D: score=1 STRING: ENSP00000362014
    ABCE1P612213, ENSP000002965774I2D: score=1 STRING: ENSP00000296577
    AIFM1O958313, ENSP000002872954I2D: score=1 STRING: ENSP00000287295
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001817regulation of cytokine production IEA--
    GO:0050860negative regulation of T cell receptor signaling pathway IEA--

    UBASH3A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBASH3A (UBS3A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBASH3A gene (3 alternative transcripts): 
    NM_001001895.2  NM_001243467.1  NM_018961.3  

    Unigene Cluster for UBASH3A:

    Ubiquitin associated and SH3 domain containing A
    Hs.473912  [show with all ESTs]
    Unigene Representative Sequence: NM_018961
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291535 ENST00000319294(uc002zbe.3 uc002zbf.3 uc010gpe.3 uc010gpc.3)
    ENST00000398367 ENST00000473381(uc010gpd.3) ENST00000450356
    miRNA
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    Block miRNA regulation of human, mouse, rat UBASH3A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBASH3A (see all 9):
    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b hsa-miR-17 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidUBASH3A 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): UBASH3A (NM_018961)
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      QuantiTect SYBR Green Assays in human, mouse, rat UBASH3A
      QuantiFast Probe-based Assays in human, mouse, rat UBASH3A

    Additional mRNA sequence: 

    AF520809.1 AF521702.1 AJ277750.1 AK301279.1 AK308151.1 AK313367.1 BC069357.1 BC069483.1 
    BC069511.1 BC069577.1 

    5 DOTS entries:

    DT.306606  DT.95363856  DT.101980504  DT.100694701  DT.121132784 

    Selected AceView cDNA sequences (see all 30):

    AI056645 NM_018961 AJ277750 AF521702 NM_001001895 AA355773 BC069577 BC069483 
    AA707211 BI907563 BX448943 AA355926 BC069511 BC069357 AJ003495 BC028138 
    BX328099 BX443486 AF520809 BX105291 BP368078 BX448944 AJ003414 AI674945 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                            -                                                                                             
    SP2:                                            -                       -                                                                     
    SP3:        -     -                             -                                                                                             
    SP4:                                -           -                                                                                             
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for UBASH3A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBASH3A expression in normal human tissues (normalized intensities)      UBASH3A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTCTGTG
    UBASH3A Expression
    About this image


    UBASH3A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    UBASH3A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBASH3A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.473912

    UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075
    Tissue specificity: Highest expression of UBASH3A in tissues belonging to the immune system, including spleen,
    peripheral blood leukocytes, thymus and bone marrow

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    QuantiFast Probe-based Assays in human, mouse, rat UBASH3A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBASH3A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UBASH3A gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubash3a1 , 5 ubiquitin associated and SH3 domain containing, A1, 5 81.86(n)1
    83.31(a)1
      17 (15.84 cM)5
    3287951  NM_177823.41  NP_808491.21 
     312078735 
    chicken
    (Gallus gallus)
    Aves UBASH3A1 ubiquitin associated and SH3 domain containing A 68.28(n)
    67.37(a)
      418535  XM_416744.4  XP_416744.3 
    lizard
    (Anolis carolinensis)
    Reptilia UBASH3A6
    ubiquitin associated and SH3 domain containing A
    61(a)
    1 ↔ 1
    3(137705883-137726554)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136043   -- 36(a)   95D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea T07F12.13   -- 35(a)   X(4929342-4931472)   --


    ENSEMBL Gene Tree for UBASH3A (if available)
    TreeFam Gene Tree for UBASH3A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBASH3A gene
    UBASH3B2  
    1 SIMAP similar gene for UBASH3A using alignment to 2 protein entries:     UBS3A_HUMAN (see all proteins):
    UBASH3B

    UBASH3A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBASH3A (see all 1404)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 21 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
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    ----------
    rs1466719301,2
    C--34320909(+) ACCCC-/TACCTC 3 -- us2k10--------
    rs1829488131,2
    --34320965(+) GAAGAA/GCAAAA 3 -- us2k10--------
    rs1875894591,2
    --34321060(+) CTAACC/TAGAGT 3 -- us2k10--------
    rs1127453801,2
    C,F--34321068(+) AGTTCC/TCACAA 3 -- us2k12Minor allele frequency- T:0.04NA EA 240
    rs1114762311,2
    C,F--34321070(+) TTCCCC/ACAAAT 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs119099301,2
    C,F,A,H--34321094(+) aaacaC/Acctag 3 -- us2k111Minor allele frequency- A:0.41NS EA NA CSA WA 638
    rs1153968841,2
    F--34321099(+) CCCTAG/ATGAAA 3 -- us2k11Minor allele frequency- A:0.08WA 118
    rs711904211,2
    C--34321101(-) TGCTCTT/-TTTTT 3 -- us2k11Minor allele frequency- -:0.00NA 2
    rs739056401,2
    C,F--34321121(+) GCAGAA/GTATCT 3 -- us2k12Minor allele frequency- G:0.07WA 120
    rs1924019581,2
    --34321182(+) AATGGA/TGCCCA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBASH3A (43824008 - 43867791 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for UBASH3A:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2723546CNV Deletion23290073
    nsv459275CNV Loss19166990
    dgv4749n71CNV Gain21882294
    esv998022CNV Gain20482838
    nsv522001CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBASH3A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605736    OMIM disorders: --

    15 diseases for UBASH3A:    About MalaCards
    dirofilariasis    erysipeloid    hantavirus pulmonary syndrome    autosomal recessive nonsyndromic deafness
    hemorrhagic fever with renal syndrome    nonsyndromic deafness    celiac disease    hemorrhagic fever
    vitiligo    type 1 diabetes    rheumatoid arthritis    arthritis
    hiv-1    systemic lupus erythematosus    lupus erythematosus


    UBASH3A for disorders           About GeneDecksing

    Genetic Association Database (GAD): UBASH3A
    Human Genome Epidemiology (HuGE) Navigator: UBASH3A (5 documents)

    Export disorders for UBASH3A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for UBASH3A gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with UBASH3A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains. (PubMed id 11281453)1, 2, 3 Wattenhofer M.... Scott H.S. (Hum. Genet. 2001)
    2. TULA proteins regulate activity of the protein tyrosine kinase Syk. (PubMed id 18189269)1, 2, 9 Agrawal R.... Tsygankov A. (J. Cell. Biochem. 2008)
    3. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. (PubMed id 21829393)1, 4 Plagnol V....Todd J.A. (PLoS Genet. 2011)
    4. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PubMed id 21383967)1, 4 Zhernakova A....Plenge R.M. (PLoS Genet. 2011)
    5. Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis. (PubMed id 20647273)1, 4 Hinks A....Thomson W. (Ann. Rheum. Dis. 2010)
    6. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. (PubMed id 20453842)1, 4 Stahl E.A....Plenge R.M. (Nat. Genet. 2010)
    7. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. (PubMed id 20410501)1, 4 Jin Y....Spritz R.A. (N. Engl. J. Med. 2010)
    8. Follow-up analysis of genome-wide association data identifies novel loci for type 1 diabetes. (PubMed id 18840781)1, 4 Grant S.F....Hakonarson H. (Diabetes 2009)
    9. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)1, 4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)
    10. Shared and distinct genetic variants in type 1 diabetes and celiac disease. (PubMed id 19073967)1, 4 Smyth D.J....Todd J.A. (N. Engl. J. Med. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 53347 HGNC: 12462 AceView: UBASH3A Ensembl:ENSG00000160185 euGenes: HUgn53347
    ECgene: UBASH3A H-InvDB: UBASH3A

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for UBASH3A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for UBASH3A gene:
    Search GeneIP for patents involving UBASH3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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