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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBASH3A Gene

protein-coding   GIFtS: 53
GCID: GC21P043824

ubiquitin associated and SH3 domain containing A
 Explore 11 diseases affiliated with
UBASH3A via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for UBASH3A    

Aliases
for UBASH3A gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, and/or 11Nature:405,311-319 and CroW21)
About This Section
Aliases
Ubiquitin Associated And SH3 Domain Containing A1 2     TULA-12 3
CLIP41 2 3     T-Cell Ubiquitin Ligand 12 3
STS-21 2 3     Gene Similar To UBA Containing SH3 Domain11
TULA1 2     T-Cell Ubiquitin Ligand Protein2
Cbl-Interacting Protein 42 3     Ubiquitin-Associated And SH3 Domain-Containing Protein A2
Suppressor Of T-Cell Receptor Signaling 22 3     STS23

External Ids:    HGNC: 124621   Entrez Gene: 533472   Ensembl: ENSG000001601857   OMIM: 6057365   UniProtKB: P570753   

Export aliases for UBASH3A gene to outside databases

Previous GC identifers: GC21P040371 GC21P042718 GC21P042697 GC21P029250


Summaries
for UBASH3A gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for UBASH3A:
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members
can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis
in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this
gene results in multiple transcript variants. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes
accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits
negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of
UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering
dynamin via its SH3 domain

Gene Wiki entry for UBASH3A


Genomic Views
for UBASH3A gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics, Whole Chromsome Sequence According to Nature (Cited Here with Permission):405,311-319 and CroW21)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.1  NT_011515.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the UBASH3A gene promoter:
         Nkx3-1   Nkx3-1 v4   GATA-3   Nkx3-1 v1   Nkx3-1 v2   POU2F1   POU2F1a   GCNF-1   Nkx3-1 v3   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBASH3A promoter sequence

   Search SABiosciences Chromatin IP Primers for UBASH3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBASH3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.3   Ensembl cytogenetic band:  21q22.3   HGNC cytogenetic band: 21q22.3
Nature(405: 311-319) cytogenetic band:   21q22.3
UBASH3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBASH3A gene location
GeneLoc information about chromosome 21         GeneLoc Exon Structure

(about GC identifiers)
GC21P043824:   GeneLoc Nature:405,311-319
Start:
 43,824,008 bp from pter       29,371,350 bp from centromere
End:
 43,867,791 bp from pter 29,415,100 bp from centromere
Size:
 43,784 bases 43,751 bases
Orientation:
 plus strand plus strand

genomic clones: KB169B4 KB994G8


Proteins
for UBASH3A gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075 (See protein sequence)
Recommended Name: Ubiquitin-associated and SH3 domain-containing protein A  
Size: 661 amino acids; 74123 Da
Subunit: Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts
with ubiquitin and with mono-ubiquitinated proteins. Interacts with dynamin
Subcellular location: Cytoplasm. Nucleus
1 PDB 3D structure from and Proteopedia for UBASH3A:
2CRN (3D)    
Secondary accessions: G5E9E4 Q6HA34 Q6HA35 Q6ISI6 Q6ISK3 Q6ISS9
Alternative splicing: 3 isoforms:  P57075-1   P57075-2   P57075-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for UBASH3A: NX_P57075

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P57075

    • UBASH3A Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001001895.1  NP_001230396.1  NP_061834.1  

    ENSEMBL proteins: 
     ENSP00000291535   ENSP00000317327   ENSP00000381408   ENSP00000407179  

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    Novus Biologicals UBASH3A Lysates
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    Uscn Proteins for UBASH3A

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol IDA16780588


    UBASH3A for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for UBASH3A gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    UBASH3A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013078 His_Pase_superF_clade-1
     IPR001452 SH3_domain
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR009060 UBA-like

    Graphical View of Domain Structure for InterPro Entry P57075

    ProtoNet protein and cluster: P57075

    2 Blocks protein families:
    IPB001345 Phosphoglycerate/bisphosphoglycerate mutase
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075
    Similarity: Contains 1 SH3 domain
    Similarity: Contains 1 UBA domain


    Function
    for UBASH3A gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075
    Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes
    accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits
    negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of
    UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering
    dynamin via its SH3 domain

    miRNA
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    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b hsa-miR-17 hsa-miR-526b*
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Animal Models:
         Mouse knock-out Ubash3atm1Jni for UBASH3A
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ubash3a):
     cellular  hematopoietic system  immune system  normal 

    UBASH3A for phenotypes           About GeneDecksing


    Pathways & Interactions
    for UBASH3A gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for UBASH3A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/14 Interacting proteins for UBASH3A (P570752, 3 ENSP000003173274) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PARK2O602602, 3, ENSP000003558654MINT-5208683 I2D: score=1 STRING: ENSP00000355865
    UBCP0CG482, 3, ENSP000003448184MINT-5208635 I2D: score=2 STRING: ENSP00000344818
    DNM1Q051932, 3, ENSP000003620144MINT-7213627 I2D: score=1 STRING: ENSP00000362014
    ABCE1P612213, ENSP000002965774I2D: score=1 STRING: ENSP00000296577
    AIFM1O958313, ENSP000002872954I2D: score=1 STRING: ENSP00000287295
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001817regulation of cytokine production IEA--
    GO:0050860negative regulation of T cell receptor signaling pathway IEA--


    UBASH3A for ontologies           About GeneDecksing



    Drugs & Compounds
    for UBASH3A gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for UBASH3A
    Search CenterWatch for drugs/clinical trials and news about UBASH3A / UBS3A 

    Transcripts
    for UBASH3A gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for UBASH3A gene (3 alternative transcripts): 
    NM_001001895.2  NM_001243467.1  NM_018961.3  

    Unigene Cluster for UBASH3A:

    Ubiquitin associated and SH3 domain containing A
    Hs.473912  [show with all ESTs]
    Unigene Representative Sequence: NM_018961
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000291535 ENST00000319294(uc002zbe.3 uc002zbf.3 uc010gpe.3 uc010gpc.3)
    ENST00000398367 ENST00000473381(uc010gpd.3) ENST00000450356

    miRNA
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    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b hsa-miR-17 hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmid: UBASH3A 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: UBASH3A
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat UBASH3A
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    Additional cDNA sequence: 

    AF520809.1 AF521702.1 AJ277750.1 AK301279.1 AK308151.1 AK313367.1 BC069357.1 BC069483.1 
    BC069511.1 BC069577.1 

    5 DOTS entries:

    DT.306606  DT.95363856  DT.101980504  DT.100694701  DT.121132784 

    24/30 AceView cDNA sequences (see all 30):

    NM_001001895 NM_018961 AF521702 AI056645 AJ277750 AA707211 BC028138 BX448943 
    BC069483 BC069511 BC069577 BX105291 AA355926 BC069357 BX443486 AA355773 
    BX328099 AJ003495 BI907563 AF520809 AJ003414 BP368078 BX448944 AI674945 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3A    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                                            -                                                                                             
    SP2:                                            -                       -                                                                     
    SP3:        -     -                             -                                                                                             
    SP4:                                -           -                                                                                             
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for UBASH3A

    Expression
    for UBASH3A gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    UBASH3A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCTTCTGTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    UBASH3A expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See UBASH3A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for UBASH3A

    SOURCE GeneReport for Unigene cluster: Hs.473912

    UniProtKB/Swiss-Prot: UBS3A_HUMAN, P57075
    Tissue specificity: Highest expression of UBASH3A in tissues belonging to the immune system, including spleen,
    peripheral blood leukocytes, thymus and bone marrow

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    In Situ
    Assay Products:     
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    Orthologs
    for UBASH3A gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for UBASH3A gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Ubash3a1 , 5 ubiquitin associated and SH3 domain containing, A1, 5 81.86(n)1
    83.31(a)1    		   17 (15.84 cM)5
    3287951  NM_177823.41  NP_808491.21 
     312078735 
    chicken
    (Gallus gallus)    		 Aves UBASH3A1 ubiquitin associated and SH3 domain containing A 68.28(n)
    67.37(a)    		   418535  XM_416744.3  XP_416744.3 
    lizard
    (Anolis carolinensis)    		 Reptilia UBASH3A6
    		 --
    		 60(a)
    		 1 ↔ 1
    		 3(137703804-137726489)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG136043   -- 36(a)   95D5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea T07F12.13   -- 35(a)   X(4929342-4931472)   --


    ENSEMBL Gene Tree for UBASH3A (if available)
    TreeFam Gene Tree for UBASH3A (if available) 

    Paralogs
    for UBASH3A gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for UBASH3A gene
    UBASH3B2  
    1 SIMAP similar gene for UBASH3A using alignment to 2 protein entries:     UBS3A_HUMAN (see all proteins):
    UBASH3B

    UBASH3A for paralogs           About GeneDecksing



    Genomic Variants
    for UBASH3A gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1076 NCBI SNPs in UBASH3A are shown (see all 1076)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 21 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1466719301,2
    		C,--43822015(+) ACCCC-/TACCTC 3 -- us2k10--------
    rs1829488131,2
    		--43822071(+) GAAGAA/GCAAAA 3 -- us2k10--------
    rs1875894591,2
    		--43822166(+) CTAACC/TAGAGT 3 -- us2k10--------
    rs1127453801,2
    		C,F,--43822174(+) AGTTCC/TCACAA 3 -- us2k12Minor allele frequency- T:0.04NA EA 240
    rs1114762311,2
    		C,--43822176(+) TTCCCC/ACAAAT 3 -- us2k11Minor allele frequency- A:0.50NA 2
    rs119099301,2
    		C,F,A,H,--43822200(+) AAACAC/ACCTAG 3 -- us2k111Minor allele frequency- A:0.41NS EA NA CSA WA 638
    rs1153968841,2
    		F,--43822205(+) CCCTAG/ATGAAA 3 -- us2k11Minor allele frequency- A:0.08WA 118
    rs711904211,2
    		C--43822208(-) TGCTCTT/-TTTTT 3 -- us2k11Minor allele frequency- -:0.00NA 2
    rs739056401,2
    		C,--43822227(+) GCAGAA/GTATCT 3 -- us2k12Minor allele frequency- G:0.07WA 120
    rs1924019581,2
    		--43822288(+) AATGGA/TGCCCA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for UBASH3A (43824008 - 43867791 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for UBASH3A: --

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    Disorders / Diseases
    for UBASH3A gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    UBASH3A for disorders           About GeneDecksing

    OMIM gene information: 605736    OMIM disorders: --

    11 diseases for UBASH3A:    About MalaCards
    autosomal recessive nonsyndromic deafness    hantavirus pulmonary syndrome    hemorrhagic fever    dirofilariasis
    nonsyndromic deafness    erysipeloid    hemorrhagic fever with renal syndrome    celiac disease
    rheumatoid arthritis    vitiligo    arthritis

    Human Genome Epidemiology (HuGE) Navigator: UBASH3A (5 documents)

    Export disorders for UBASH3A gene to outside databases

    Publications
    for UBASH3A gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for UBASH3A gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with UBASH3A)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains. (PubMed id 11281453)1, 2, 3 Wattenhofer M.... Scott H.S. (2001)
    2. TULA proteins regulate activity of the protein tyrosine kinase Syk. (PubMed id 18189269)1, 2, 9 Agrawal R....Tsygankov A. (2008)
    3. The Cbl-interacting protein TULA inhibits dynamin-dependent endocytosis. (PubMed id 17382318)1, 2 Bertelsen V....Madshus I.H. (2007)
    4. Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases. (PubMed id 15159412)1, 2 Kowanetz K....Dikic I. (2004)
    5. TULA: an SH3- and UBA-containing protein that binds to c-Cbl and ubiquitin. (PubMed id 15107835)1, 2 Feshchenko E.A.... Tsygankov A.Y. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis. (PubMed id 17709377)1, 9 Collingwood T.S....Tsygankov A.Y. (2007)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Genome-wide association analysis of autoantibody posit ivity in type 1 diabetes cases. (PubMed id 21829393)1 Plagnol V....Todd J.A. (2011)
    10. Meta-analysis of genome-wide association studies in c eliac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. (PubMed id 21383967)1 Zhernakova A....Plenge R.M. (2011)

    External Searches for UBASH3A gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing UBASH3A gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53347 HGNC: 12462 AceView: UBASH3A Ensembl:ENSG00000160185 euGenes: HUgn53347
    ECgene: UBASH3A H-InvDB: UBASH3A

    Other Databases showing UBASH3A gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing UBASH3A gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for UBASH3A Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for UBASH3A gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for UBASH3A gene:
    Search GeneIP for patents involving UBASH3A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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