Free for academic non-profit institutions. Other users need a Commercial license

Aliases for UBASH3A Gene

Aliases for UBASH3A Gene

  • Ubiquitin Associated And SH3 Domain Containing A 2 3 5
  • Suppressor Of T-Cell Receptor Signaling 2 3 4
  • T-Cell Ubiquitin Ligand Protein 2 3
  • Cbl-Interacting Protein 4 3 4
  • T-Cell Ubiquitin Ligand 1 3 4
  • TULA-1 3 4
  • CLIP4 3 4
  • STS-2 3 4
  • TULA 3
  • STS2 4

External Ids for UBASH3A Gene

Previous GeneCards Identifiers for UBASH3A Gene

  • GC21P040371
  • GC21P042718
  • GC21P042697
  • GC21P043824
  • GC21P029250

Summaries for UBASH3A Gene

Entrez Gene Summary for UBASH3A Gene

  • This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]

GeneCards Summary for UBASH3A Gene

UBASH3A (Ubiquitin Associated And SH3 Domain Containing A) is a Protein Coding gene. Diseases associated with UBASH3A include erysipeloid. An important paralog of this gene is UBASH3B.

UniProtKB/Swiss-Prot for UBASH3A Gene

  • Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.

Gene Wiki entry for UBASH3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBASH3A Gene

Genomics for UBASH3A Gene

Regulatory Elements for UBASH3A Gene

Enhancers for UBASH3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBASH3A on UCSC Golden Path with GeneCards custom track

Promoters for UBASH3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBASH3A on UCSC Golden Path with GeneCards custom track

Genomic Location for UBASH3A Gene

Chromosome:
21
Start:
42,403,447 bp from pter
End:
42,447,688 bp from pter
Size:
44,242 bases
Orientation:
Plus strand

Genomic View for UBASH3A Gene

Genes around UBASH3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBASH3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBASH3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBASH3A Gene

Proteins for UBASH3A Gene

  • Protein details for UBASH3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57075-UBS3A_HUMAN
    Recommended name:
    Ubiquitin-associated and SH3 domain-containing protein A
    Protein Accession:
    P57075
    Secondary Accessions:
    • G5E9E4
    • Q6HA34
    • Q6HA35
    • Q6ISI6
    • Q6ISK3
    • Q6ISS9

    Protein attributes for UBASH3A Gene

    Size:
    661 amino acids
    Molecular mass:
    74123 Da
    Quaternary structure:
    • Homodimer or homooligomer. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. Interacts with dynamin.

    Three dimensional structures from OCA and Proteopedia for UBASH3A Gene

    Alternative splice isoforms for UBASH3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBASH3A Gene

Proteomics data for UBASH3A Gene at MOPED

Post-translational modifications for UBASH3A Gene

  • Ubiquitination at Lys 240, Lys 347, Lys 413, Lys 425, Lys 445, Lys 516, and Lys 521
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for UBASH3A

No data available for DME Specific Peptides for UBASH3A Gene

Domains & Families for UBASH3A Gene

Suggested Antigen Peptide Sequences for UBASH3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P57075

UniProtKB/Swiss-Prot:

UBS3A_HUMAN :
  • Contains 1 SH3 domain.
Domain:
  • Contains 1 SH3 domain.
  • Contains 1 UBA domain.
genes like me logo Genes that share domains with UBASH3A: view

No data available for Gene Families for UBASH3A Gene

Function for UBASH3A Gene

Molecular function for UBASH3A Gene

UniProtKB/Swiss-Prot Function:
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain.
genes like me logo Genes that share phenotypes with UBASH3A: view

Animal Models for UBASH3A Gene

MGI Knock Outs for UBASH3A:

Animal Model Products

CRISPR Products

miRNA for UBASH3A Gene

miRTarBase miRNAs that target UBASH3A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBASH3A Gene

Localization for UBASH3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBASH3A Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBASH3A Gene COMPARTMENTS Subcellular localization image for UBASH3A gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for UBASH3A Gene

Pathways & Interactions for UBASH3A Gene

SuperPathways for UBASH3A Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBASH3A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBASH3A Gene

Drugs & Compounds for UBASH3A Gene

No Compound Related Data Available

Transcripts for UBASH3A Gene

Unigene Clusters for UBASH3A Gene

Ubiquitin associated and SH3 domain containing A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBASH3A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5:

Relevant External Links for UBASH3A Gene

GeneLoc Exon Structure for
UBASH3A
ECgene alternative splicing isoforms for
UBASH3A

Expression for UBASH3A Gene

mRNA expression in normal human tissues for UBASH3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UBASH3A Gene

This gene is overexpressed in Whole Blood (x16.8), Spleen (x8.4), and Small Intestine - Terminal Ileum (x5.9).

Protein differential expression in normal tissues from HIPED for UBASH3A Gene

This gene is overexpressed in CD8 Tcells (39.8) and Peripheral blood mononuclear cells (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBASH3A Gene



SOURCE GeneReport for Unigene cluster for UBASH3A Gene Hs.473912

mRNA Expression by UniProt/SwissProt for UBASH3A Gene

P57075-UBS3A_HUMAN
Tissue specificity: Highest expression of UBASH3A in tissues belonging to the immune system, including spleen, peripheral blood leukocytes, thymus and bone marrow.
genes like me logo Genes that share expression patterns with UBASH3A: view

Protein tissue co-expression partners for UBASH3A Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for UBASH3A Gene

This gene was present in the common ancestor of animals.

Orthologs for UBASH3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBASH3A 35
  • 83.65 (n)
  • 84.73 (a)
UBASH3A 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBASH3A 35
  • 85.64 (n)
  • 85.85 (a)
UBASH3A 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubash3a 35
  • 81.86 (n)
  • 83.31 (a)
Ubash3a 16
Ubash3a 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBASH3A 35
  • 98.82 (n)
  • 98.39 (a)
UBASH3A 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBASH3A 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBASH3A 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBASH3A 35
  • 68.28 (n)
  • 67.37 (a)
UBASH3A 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBASH3A 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13604 37
  • 36 (a)
CG13604 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07F12.1 37
  • 35 (a)
T07F12.1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
Species with no ortholog for UBASH3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for UBASH3A Gene

ENSEMBL:
Gene Tree for UBASH3A (if available)
TreeFam:
Gene Tree for UBASH3A (if available)

Paralogs for UBASH3A Gene

Paralogs for UBASH3A Gene

(1) SIMAP similar genes for UBASH3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with UBASH3A: view

Variants for UBASH3A Gene

Sequence variations from dbSNP and Humsavar for UBASH3A Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs2277798 - 42,403,997(+) TCAAG(A/G)GCCGC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2277800 - 42,404,027(+) AGCCC(C/T)TCCTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs13048049 -, -, - 42,418,534(+) ACAGC(A/G/T)GACGG nc-transcript-variant, reference, missense
rs17114930 - 42,437,492(+) GGGGA(A/C/G/T)GCGCT nc-transcript-variant, reference, missense
rs2254368 -- 42,442,356(+) TAGAC(A/G)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBASH3A Gene

Variant ID Type Subtype PubMed ID
dgv4749n71 CNV Gain 21882294
nsv522001 CNV Gain 19592680
esv2723546 CNV Deletion 23290073
esv998022 CNV Gain 20482838
nsv459275 CNV Loss 19166990

Variation tolerance for UBASH3A Gene

Residual Variation Intolerance Score: 79.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.66; 65.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBASH3A Gene

HapMap Linkage Disequilibrium report
UBASH3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBASH3A Gene

Disorders for UBASH3A Gene

MalaCards: The human disease database

(1) MalaCards diseases for UBASH3A Gene - From: DISEASES

Disorder Aliases PubMed IDs
erysipeloid
  • infection due to erysipelothrix rhusiopathiae
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for UBASH3A

Genetic Association Database (GAD)
UBASH3A
Human Genome Epidemiology (HuGE) Navigator
UBASH3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBASH3A
genes like me logo Genes that share disorders with UBASH3A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UBASH3A Gene

Publications for UBASH3A Gene

  1. Isolation and characterization of the UBASH3A gene on 21q22.3 encoding a potential nuclear protein with a novel combination of domains. (PMID: 11281453) Wattenhofer M. … Scott H.S. (Hum. Genet. 2001) 2 3 4 67
  2. TULA proteins regulate activity of the protein tyrosine kinase Syk. (PMID: 18189269) Agrawal R. … Tsygankov A. (J. Cell. Biochem. 2008) 3 23
  3. T-cell ubiquitin ligand affects cell death through a functional interaction with apoptosis-inducing factor, a key factor of caspase-independent apoptosis. (PMID: 17709377) Collingwood T.S. … Tsygankov A.Y. (J. Biol. Chem. 2007) 3 23
  4. Association of UBASH3A gene polymorphisms and systemic lupus erythematosus in a Chinese population. (PMID: 25843625) Liu J. … Ye D.Q. (Gene 2015) 3
  5. Lack of association between polymorphisms in the UBASH3A gene and autoimmune thyroid disease: a case control study. (PMID: 25211447) Cai T. … Zhang J. (Arq Bras Endocrinol Metabol 2014) 3

Products for UBASH3A Gene

Sources for UBASH3A Gene

Content