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Aliases for UBAP2L Gene

Aliases for UBAP2L Gene

  • Ubiquitin Associated Protein 2 Like 2 3 5
  • Protein NICE-4 3 4
  • NICE4 3 4
  • Ubiquitin Associated Protein 2-Like 2
  • Ubiquitin-Associated Protein 2-Like 3
  • KIAA0144 4
  • NICE-4 3

External Ids for UBAP2L Gene

Previous GeneCards Identifiers for UBAP2L Gene

  • GC01P151006
  • GC01P152459
  • GC01P125556

Summaries for UBAP2L Gene

GeneCards Summary for UBAP2L Gene

UBAP2L (Ubiquitin Associated Protein 2 Like) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is UBAP2.

UniProtKB/Swiss-Prot for UBAP2L Gene

  • Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).

Gene Wiki entry for UBAP2L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAP2L Gene

Genomics for UBAP2L Gene

Regulatory Elements for UBAP2L Gene

Enhancers for UBAP2L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G154177 1.8 FANTOM5 ENCODE dbSUPER 14.4 -39.1 -39071 6.8 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC UBAP2L NUP210L C1orf189 ENSG00000201129 HAX1 ATP8B2 RNU7-57P IL6R CREB3L4 ADAR
GH01G154333 1.5 Ensembl ENCODE dbSUPER 10.3 +114.7 114740 2.2 PKNOX1 FOXA2 ARID4B SIN3A ZNF48 YY1 ZNF121 ELK1 ZNF143 FOS UBE2Q1 IL6R LOC101928101 ENSG00000201129 UBAP2L TPM3 MIR190B C1orf189 UBE2Q1-AS1 ATP8B2
GH01G154404 1.4 ENCODE dbSUPER 9.8 +187.4 187431 5.8 HDGF FOXA2 MLX ZFP64 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ATP8B2 RNU7-57P UBE2Q1-AS1 UBE2Q1 TDRD10 SHE ENSG00000201129 UBAP2L C1orf189 ADAR
GH01G154479 1.4 Ensembl ENCODE dbSUPER 9.5 +260.1 260050 0.8 RB1 TBL1XR1 ARNT WRNIP1 SIN3A ARID4B ZNF2 RAD21 CHAMP1 RFX5 IL6R UBE2Q1-AS1 UBE2Q1 SHE TDRD10 LOC101928101 CHRNB2 RNU7-57P ATP8B2 ENSG00000201129
GH01G154453 1.3 Ensembl ENCODE dbSUPER 9.5 +234.2 234182 2.0 ZSCAN4 ZNF133 KLF17 RAD21 ZNF48 YY1 RARA ZNF335 ZBTB48 EED IL6R LOC101928101 UBE2Q1 CHRNB2 RNU7-57P ATP8B2 UBE2Q1-AS1 ENSG00000201129 UBAP2L C1orf189
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBAP2L on UCSC Golden Path with GeneCards custom track

Promoters for UBAP2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000013887 949 3001 HDGF PKNOX1 MLX CREB3L1 ARNT ZFP64 WRNIP1 ARID4B SIN3A FEZF1

Genomic Location for UBAP2L Gene

Chromosome:
1
Start:
154,219,951 bp from pter
End:
154,271,510 bp from pter
Size:
51,560 bases
Orientation:
Plus strand

Genomic View for UBAP2L Gene

Genes around UBAP2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBAP2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBAP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAP2L Gene

Proteins for UBAP2L Gene

  • Protein details for UBAP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14157-UBP2L_HUMAN
    Recommended name:
    Ubiquitin-associated protein 2-like
    Protein Accession:
    Q14157
    Secondary Accessions:
    • B4E0U8
    • Q5VU75
    • Q5VU76
    • Q9BTU3
    • Q9UGL2
    • Q9UGL3
    • Q9UGL4
    • Q9UGL5

    Protein attributes for UBAP2L Gene

    Size:
    1087 amino acids
    Molecular mass:
    114535 Da
    Quaternary structure:
    • Interacts with BMI1 (PubMed:25185265). Part of a complex consisting of UBAP2L, BMI1 and RNF2(PubMed:25185265).
    SequenceCaution:
    • Sequence=CAB65100.2; Type=Frameshift; Positions=1085; Evidence={ECO:0000305};

    Alternative splice isoforms for UBAP2L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBAP2L Gene

Post-translational modifications for UBAP2L Gene

No data available for DME Specific Peptides for UBAP2L Gene

Domains & Families for UBAP2L Gene

Protein Domains for UBAP2L Gene

Suggested Antigen Peptide Sequences for UBAP2L Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBAP2L: view

No data available for Gene Families and UniProtKB/Swiss-Prot for UBAP2L Gene

Function for UBAP2L Gene

Molecular function for UBAP2L Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).

Gene Ontology (GO) - Molecular Function for UBAP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 19945174
genes like me logo Genes that share ontologies with UBAP2L: view
genes like me logo Genes that share phenotypes with UBAP2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBAP2L Gene

Localization for UBAP2L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBAP2L gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for UBAP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005671 colocalizes_with Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0005737 cytoplasm IBA --
GO:0031519 PcG protein complex IDA 25185265
genes like me logo Genes that share ontologies with UBAP2L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBAP2L Gene

Pathways & Interactions for UBAP2L Gene

SuperPathways for UBAP2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBAP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007339 binding of sperm to zona pellucida IMP 19945174
GO:0010628 positive regulation of gene expression IBA --
GO:0061484 hematopoietic stem cell homeostasis IGI 25185265
genes like me logo Genes that share ontologies with UBAP2L: view

No data available for Pathways by source and SIGNOR curated interactions for UBAP2L Gene

Drugs & Compounds for UBAP2L Gene

No Compound Related Data Available

Transcripts for UBAP2L Gene

Unigene Clusters for UBAP2L Gene

Ubiquitin associated protein 2-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a ·
SP1: - - -
SP2: - - - -
SP3:
SP4:
SP5: - -
SP6: -
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31a · 31b
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP5:
SP6:
SP7: - - - - - - -
SP8:
SP9: - - -
SP10: - -
SP11: - - - -
SP12:
SP13:
SP14: - - - - -
SP15:
SP16: -
SP17:

Relevant External Links for UBAP2L Gene

GeneLoc Exon Structure for
UBAP2L
ECgene alternative splicing isoforms for
UBAP2L

Expression for UBAP2L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBAP2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBAP2L Gene

This gene is overexpressed in Bone marrow stromal cell (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBAP2L Gene



Protein tissue co-expression partners for UBAP2L Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBAP2L Gene:

UBAP2L

SOURCE GeneReport for Unigene cluster for UBAP2L Gene:

Hs.490551

mRNA Expression by UniProt/SwissProt for UBAP2L Gene:

Q14157-UBP2L_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for UBAP2L Gene

  • Nervous system(4.7)
  • Skin(4.6)
  • Bone marrow(4.3)
  • Liver(4.3)
  • Lung(3.1)
  • Intestine(2.2)
  • Eye(2)
genes like me logo Genes that share expression patterns with UBAP2L: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBAP2L Gene

Orthologs for UBAP2L Gene

This gene was present in the common ancestor of animals.

Orthologs for UBAP2L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBAP2L 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia UBAP2L 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia UBAP2L 34 35
  • 96.18 (n)
oppossum
(Monodelphis domestica)
Mammalia UBAP2L 35
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubap2l 35
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Atp8b2 34
  • 94.44 (n)
chicken
(Gallus gallus)
Aves UBAP2L 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBAP2L 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubap2l 34
  • 71.46 (n)
Str.5318 34
zebrafish
(Danio rerio)
Actinopterygii ubap2l 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta lig 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1157 35
  • 36 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
Species where no ortholog for UBAP2L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAP2L Gene

ENSEMBL:
Gene Tree for UBAP2L (if available)
TreeFam:
Gene Tree for UBAP2L (if available)

Paralogs for UBAP2L Gene

Paralogs for UBAP2L Gene

(1) SIMAP similar genes for UBAP2L Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with UBAP2L: view

Variants for UBAP2L Gene

Sequence variations from dbSNP and Humsavar for UBAP2L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000086133 -- 154,269,193(+) CCCTT(-/CTC)CTCCT intron-variant
rs1000152606 -- 154,223,333(+) AGATA(C/T)CACAT intron-variant, upstream-variant-2KB
rs1000161222 -- 154,243,601(+) GATTA(C/G)AGGCG intron-variant
rs1000173291 -- 154,270,775(+) TTTTT(-/G/TG)TTTTT intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000212624 -- 154,237,302(+) GTGCA(C/T)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBAP2L Gene

Variant ID Type Subtype PubMed ID
esv2672763 CNV deletion 23128226
nsv1143469 CNV deletion 24896259
nsv2954 CNV insertion 18451855
nsv521887 CNV gain 19592680

Variation tolerance for UBAP2L Gene

Residual Variation Intolerance Score: 2.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBAP2L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBAP2L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBAP2L Gene

Disorders for UBAP2L Gene

Relevant External Links for UBAP2L

Human Genome Epidemiology (HuGE) Navigator
UBAP2L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBAP2L

No disorders were found for UBAP2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBAP2L Gene

Publications for UBAP2L Gene

  1. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I. … Mischke D. (Genome Res. 2001) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3 4 64
  3. UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity. (PMID: 25185265) Bordeleau M.E. … Sauvageau G. (Blood 2014) 3 4 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64

Products for UBAP2L Gene

Sources for UBAP2L Gene

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