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UBAP2L Gene

protein-coding   GIFtS: 53
GCID: GC01P154192

Ubiquitin Associated Protein 2-Like

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ubiquitin Associated Protein 2-Like1 2
Protein NICE-42 3
NICE-42
Ubiquitin-Associated Protein 2-Like2
KIAA01443
NICE43

External Ids:    HGNC: 298771   Entrez Gene: 98982   Ensembl: ENSG000001435697   UniProtKB: Q141573   

Export aliases for UBAP2L gene to outside databases

Previous GC identifers: GC01P151006 GC01P152459 GC01P125556


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for UBAP2L Gene:
UBAP2L (ubiquitin associated protein 2-like) is a protein-coding gene. Diseases associated with UBAP2L include hepatitis b, and ataxia. An important paralog of this gene is UBAP2.

Gene Wiki entry for UBAP2L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the UBAP2L gene promoter:
         AREB6   Max1   Hand1   Pax-4a   c-Myc   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidUBAP2L promoter sequence
   Search Chromatin IP Primers for UBAP2L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat UBAP2L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21.3   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21.3

UBAP2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBAP2L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P154192:  view genomic region     (about GC identifiers)

Start:
154,192,655 bp from pter      End:
154,243,986 bp from pter
Size:
51,332 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: UBP2L_HUMAN, Q14157 (See protein sequence)
Recommended Name: Ubiquitin-associated protein 2-like  
Size: 1087 amino acids; 114535 Da
Sequence caution: Sequence=CAB65100.2; Type=Frameshift; Positions=1085;
Secondary accessions: B4E0U8 Q5VU75 Q5VU76 Q9BTU3 Q9UGL2 Q9UGL3 Q9UGL4 Q9UGL5
Alternative splicing: 5 isoforms:  Q14157-2   Q14157-1   Q14157-3   Q14157-4   Q14157-5   (No experimental confirmation available. Contains a N6-acetyllysine at position 969)

Explore the universe of human proteins at neXtProt for UBAP2L: NX_Q14157

Explore proteomics data for UBAP2L at MOPED

Post-translational modifications: 

  • Acetylated1
  • Ubiquitination2 at Lys353, Lys420, Lys864, Lys970, Lys976
  • Modification sites at PhosphoSitePlus

  • See UBAP2L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001120792.1  NP_001274744.1  NP_001274745.1  NP_055662.3  

    ENSEMBL proteins: 
     ENSP00000345308   ENSP00000399920   ENSP00000389052   ENSP00000357490   ENSP00000389717  
     ENSP00000415310   ENSP00000355343   ENSP00000407672   ENSP00000398609   ENSP00000271877  
     ENSP00000389445  

    UBAP2L Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    Novus Biologicals UBAP2L Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for UBAP2L

    UBAP2L Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals UBAP2L Antibodies
    Abcam antibodies for UBAP2L
    Cloud-Clone Corp. Antibodies for UBAP2L
    Search ThermoFisher Antibodies for UBAP2L
    LSBio Antibodies in human, mouse, rat for UBAP2L

    UBAP2L Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for UBAP2L
    Cloud-Clone Corp. CLIAs for UBAP2L


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR009060 UBA-like
     IPR022166 DUF3697_Uba2
     IPR015940 UBA/transl_elong_EF1B_N_euk

    Graphical View of Domain Structure for InterPro Entry Q14157

    ProtoNet protein and cluster: Q14157

    1 Blocks protein domain: IPB000449 Ubiquitin-associated domain

    UniProtKB/Swiss-Prot: UBP2L_HUMAN, Q14157
    Similarity: Contains 1 UBA domain


    UBAP2L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19945174
    GO:0044822poly(A) RNA binding IDA--
         
    UBAP2L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for UBAP2L:
     Synthetic lethal with Ras 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ubap2l):
     growth/size/body  reproductive system 

    UBAP2L for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for UBAP2L
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for UBAP2L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for UBAP2L
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for UBAP2L

    miRNA
    Products:
        
    miRTarBase miRNAs that target UBAP2L:
    hsa-mir-484 (MIRT042154), hsa-mir-25-3p (MIRT050306), hsa-let-7a-5p (MIRT052461), hsa-let-7b-5p (MIRT032290), hsa-mir-320a (MIRT044564), hsa-let-7f-5p (MIRT051370), hsa-mir-93-3p (MIRT038905), hsa-mir-93-5p (MIRT048780), hsa-mir-92a-3p (MIRT049151), hsa-let-7e-5p (MIRT051449), hsa-mir-760 (MIRT036779), hsa-mir-125b-5p (MIRT045996)

    Block miRNA regulation of human, mouse, rat UBAP2L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBAP2L (see all 72):
    hsa-miR-194* hsa-miR-300 hsa-miR-374a hsa-miR-3613-3p hsa-miR-642b hsa-miR-761 hsa-miR-130b hsa-miR-1206
    SwitchGear 3'UTR luciferase reporter plasmidUBAP2L 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for UBAP2L
    Predesigned siRNA for gene silencing in human, mouse, rat UBAP2L

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for UBAP2L

    Clone
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    OriGene clones in human, mouse for UBAP2L (see all 16)
    OriGene ORF clones in mouse, rat for UBAP2L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBAP2L (NM_001127320)
    Sino Biological Human cDNA Clone for UBAP2L
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBAP2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBAP2L

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for UBAP2L
    Browse ESI BIO Cell Lines and PureStem Progenitors for UBAP2L 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBAP2L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005671colocalizes with Ada2/Gcn5/Ada3 transcription activator complex IDA18838386

    UBAP2L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for UBAP2L
    Interactions:

        Search GeneGlobe Interaction Network for UBAP2L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for UBAP2L (Q141572, 3 ENSP000003553434) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000225748P486342, 3, ENSP000003874774MINT-62807 MINT-62633 MINT-62731 I2D: score=5 STRING: ENSP00000387477
    PRRC2AP486342, 3, ENSP000003651754MINT-62807 MINT-62633 MINT-62731 I2D: score=5 STRING: ENSP00000365175
    ENSG00000206427P486342, 3MINT-62807 MINT-62633 MINT-62731 I2D: score=5 
    ENSG00000225164P486342, 3MINT-62807 MINT-62633 MINT-62731 I2D: score=5 
    ENSG00000226618P486342, 3MINT-62807 MINT-62633 MINT-62731 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007339binding of sperm to zona pellucida IMP19945174

    UBAP2L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for UBAP2L (UBP2L)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for UBAP2L gene (4 alternative transcripts): 
    NM_001127320.2  NM_001287815.1  NM_001287816.1  NM_014847.3  

    Unigene Cluster for UBAP2L:

    Ubiquitin associated protein 2-like
    Hs.490551  [show with all ESTs]
    Unigene Representative Sequence: NM_014847
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000343815(uc009wot.3 uc010pek.2 uc010pen.2) ENST00000441890
    ENST00000412596 ENST00000368504 ENST00000437652(uc021pad.1) ENST00000456325(uc010pem.1)
    ENST00000361546(uc001fer.3) ENST00000466173 ENST00000495676 ENST00000489076
    ENST00000433615(uc001feq.3) ENST00000428595 ENST00000465855 ENST00000484696
    ENST00000475373 ENST00000493867 ENST00000484819 ENST00000271877(uc010pel.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat UBAP2L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate UBAP2L (see all 72):
    hsa-miR-194* hsa-miR-300 hsa-miR-374a hsa-miR-3613-3p hsa-miR-642b hsa-miR-761 hsa-miR-130b hsa-miR-1206
    SwitchGear 3'UTR luciferase reporter plasmidUBAP2L 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for UBAP2L
    Predesigned siRNA for gene silencing in human, mouse, rat UBAP2L
    Clone
    Products:
         
    OriGene clones in human, mouse for UBAP2L (see all 16)
    OriGene ORF clones in mouse, rat for UBAP2L
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): UBAP2L (NM_001127320)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for UBAP2L
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat UBAP2L
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for UBAP2L
    OriGene qSTAR qPCR primer pairs in human, mouse for UBAP2L
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBAP2L
      QuantiTect SYBR Green Assays in human, mouse, rat UBAP2L
      QuantiFast Probe-based Assays in human, mouse, rat UBAP2L

    Additional mRNA sequence: 

    AJ227866.1 AJ243668.1 AJ243669.2 AJ243670.2 AK124294.1 AK302662.1 AK302953.1 AK303533.1 
    BC003170.1 D63478.1 

    Selected DOTS entries (see all 50):

    DT.92462303  DT.87016649  DT.102842187  DT.100812300  DT.95156742  DT.100812302  DT.75111666  DT.92044677 
    DT.75131711  DT.100806956  DT.121356132  DT.95156729  DT.441503  DT.100812304  DT.100045235  DT.102842171 
    DT.75164978  DT.121356078  DT.121356144  DT.92462365  DT.95156763  DT.100812299  DT.95156764  DT.100726342 

    Selected AceView cDNA sequences (see all 35):

    AA055416 BM699292 AL523107 AL530533 AA259160 BM669510 AL121120 BI711109 
    AW051361 AI392934 AI341957 H71871 BQ378854 AV743562 BF897398 AI673123 
    T18975 BF204983 BF333044 BF327581 H48757 BQ344650 AA259120 AI695208 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2L (see all 17)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a ·
    SP1:                                -           -                                   -                                                                           
    SP2:        -                       -           -                                   -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -                                               -                                                                           

    ExUns: 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31a · 31b
    SP1:                          -     -     -     -           -                                         -     -                       -     -                     
    SP2:                          -     -     -     -           -                                                                                                   
    SP3:                          -     -     -     -           -                                         -     -                       -     -     -               
    SP4:                          -     -     -     -           -                                         -     -                       -                           
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for UBAP2L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    UBAP2L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    UBAP2L Expression
    About this image


    UBAP2L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Uterus (Reproductive System)
     
     Lung (Respiratory System)
     
     Thyroid (Endocrine System)
    UBAP2L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    UBAP2L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.490551

    UniProtKB/Swiss-Prot: UBP2L_HUMAN, Q14157
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for UBAP2L
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat UBAP2L
    QuantiTect SYBR Green Assays in human, mouse, rat UBAP2L
    QuantiFast Probe-based Assays in human, mouse, rat UBAP2L
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBAP2L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for UBAP2L gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ubap2l5 ubiquitin associated protein 2-like   --   3 (39.19 cM) 89999589 
    chicken
    (Gallus gallus)
    Aves UBAP2L6
    ubiquitin associated protein 2-like
    88(a)
    1 ↔ 1
    25(1301334-1320300)
    lizard
    (Anolis carolinensis)
    Reptilia UBAP2L6
    ubiquitin associated protein 2-like
    76(a)
    1 ↔ 1
    AAWZ02038725(21-10592)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480311222   -- 77.42(n)    48031122 
    zebrafish
    (Danio rerio)
    Actinopterygii ubap2l6
    ubiquitin associated protein 2-like
    61(a)
    1 ↔ 1
    19(8380218-8420488) ENSDARG00000063219
    fruit fly
    (Drosophila melanogaster)
    Insecta lig6
    lingerer
    17(a)
    1 → many
    2R(3955460-3966320)


    ENSEMBL Gene Tree for UBAP2L (if available)
    TreeFam Gene Tree for UBAP2L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for UBAP2L gene
    UBAP22  
    1 SIMAP similar gene for UBAP2L using alignment to 9 protein entries:     UBP2L_HUMAN (see all proteins):
    UBAP2

    UBAP2L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for UBAP2L (see all 958)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840411291,2
    --154195303(+) TTTCAG/TTGAAA 2 -- int10--------
    rs1892672801,2
    --154195370(+) TGTGTA/TGAAAC 2 -- int10--------
    rs1463004361,2
    --154195391(+) TCTCGC/TACGAT 2 -- int10--------
    rs1806987721,2
    --154195466(+) AAGTAA/GGTAAC 2 -- int10--------
    rs354350241,2
    C--154195599(+) GTGGT-/AAAAAT 2 -- int12Minor allele frequency- A:0.25NA CSA 4
    rs756574601,2
    --154195603(+) TAAAAA/TTTTTC 2 -- int10--------
    rs2012482251,2
    --154195604(+) AAAAA-/TTTTCT 2 -- int10--------
    rs1382566791,2
    --154195712(+) ACTTTC/TTAATA 2 -- int10--------
    rs43931491,2
    C,F,A,H--154195753(+) ATAGTA/GTATAG 2 -- int121Minor allele frequency- G:0.19NS EA NA WA CSA 2246
    rs1428244691,2
    --154195844(+) TGTAAA/GTTACA 2 -- int10--------

    HapMap Linkage Disequilibrium report for UBAP2L (154192655 - 154243986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for UBAP2L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2672763CNV Deletion23128226
    nsv2954CNV Insertion18451855
    nsv521887CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing UBAP2L
    DNA2.0 Custom Variant and Variant Library Synthesis for UBAP2L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for UBAP2L:    
    About MalaCards
    hepatitis b    ataxia    hepatitis    breast cancer


    UBAP2L for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: UBAP2L (2 documents)

    Export disorders for UBAP2L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for UBAP2L gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with UBAP2L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159)1, 2, 3 Marenholz I....Mischke D. (Genome Res. 2001)
    2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PubMed id 23349634)1 Cloutier P.... Coulombe B. (PLoS Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9898 HGNC: 29877 AceView: UBAP2L.1 Ensembl:ENSG00000143569 euGenes: HUgn9898
    ECgene: UBAP2L H-InvDB: UBAP2L

    (According to HUGE)
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    HUGE: KIAA0144

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for UBAP2L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for UBAP2L gene:
    Search GeneIP for patents involving UBAP2L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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