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Aliases & Descriptions for UBAP2L
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ42300 2 KIAA0144 1 , 2 , 3 NICE-4 1 , 2 NICE4 3 OTTHUMP00000034204 2
Descriptions Protein NICE-4 3 ubiquitin associated protein 2-like 2
Search outside databases for aliases for UBAP2L genePrevious GC identifer: GC01P151006
Summaries for UBAP2L (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for UBAP2L
Genomic Location for UBAP2L
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the UBAP2L gene Entrez Gene cytogenetic band: 1q21.3 Ensembl cytogenetic band: 1q21.3 HGNC cytogenetic band: 1q21.3 UBAP2L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01P152459:
(about GC identifiers )
Start:
152,459,279 bp from pter
End:
152,510,019 bp from pter
Size:
50,741 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000001.9 NT_004487.18 Proteins for UBAP2L
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: UBP2L_HUMAN, Q14157 (See
protein sequence )Recommended Name: Ubiquitin-associated protein 2-like Size : 1087 amino acids; 114535 Da
Secondary accessions : Q5VU75 Q5VU76 Q9BTU3 Q9UGL2 Q9UGL3 Q9UGL5Alternative splicing : 3 isoforms : Q14157-2 Q14157-1 Q14157-3
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001120792.1 NP_055662.3 ENSEMBL proteins: ENSP00000271877 ENSP00000355343 ENSP00000357491 ENSP00000345308 ENSP00000357490 ENSP00000308491 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for UBAP2L: Assays for UBAP2L:
Protein
Domains/ Families for UBAP2L(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q14157 ProtoNet protein and cluster: Q14157
1 Blocks protein family : IPB000449 Ubiquitin-associated domain UniProtKB/Swiss-Prot: UBP2L_HUMAN, Q14157 Similarity : Contains 1 UBA domain
Gene Function for UBAP2L
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001127320 Applied Biosystems Silencer ® siRNAs for UBAP2L Sigma-Aldrich siRNA and siRNA Panels for UBAP2L Sigma-Aldrich shRNA for UBAP2L Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127320                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127320                                  untagged cDNA clones in CMV expression vector (see all 5 ): BC003170  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: BC003170 1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for UBAP2L
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for UBAP2L (Q14157 1 ENSP00000271877 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for UBAP2L (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for UBAP2L(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001127320 Sigma-Aldrich siRNA and siRNA Panels for UBAP2L Sigma-Aldrich shRNA for UBAP2L Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001127320 NM_014847
REFSEQ mRNAs for UBAP2L gene (2 alternative transcripts): NM_001127320.1 NM_014847.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001127320 NM_014847
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127320                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001127320                                  untagged cDNA clones in CMV expression vector (see all 5 ): BC003170  
Additional cDNA sequence: AJ227866.1 AJ243668.1 AJ243669.2 AJ243670.2 AK124294.1 AK302662.1 AK302953.1 AK303533.1 AM413003.1 BC003170.1 CR598011.1 CR617355.1 D63478.1
24/52 DOTS entries (see all 52
): DT.92462303 DT.87016649 DT.102842187 DT.100812300 DT.95156742 DT.100812302 DT.75111666 DT.92044677 DT.75131711 DT.100806956 DT.121356132 DT.95156729 DT.441503 DT.100812304 DT.100045235 DT.102842171 DT.121356078 DT.75164978 DT.121356144 DT.92462365 DT.95156763 DT.100812299 DT.86996563 DT.95156764
24/35 AceView cDNA sequences (see all 35
):AA055416 BM699292 AA259160 BM669510 AL523107 AL530533 BI711109 AL121120 AI341957 AI392934 AW051361 BQ378854 H71871 BF333044 BF204983 AI673123 BF327581 H48757 BF897398 AV743562 T18975 BQ344650 AA259120 AI885038
highest scoring ESTs for UBAP2L :AA126733 AI950323 AW005814 AA055416 AA401629 AA410854 AA573288 AA759195 AA775085 AA837980
Unigene Cluster for UBAP2L: Ubiquitin associated protein 2-like Hs.490551 [show with all ESTs ] Unigene Representative Sequence: NM_014847 GeneLoc Exon Structure 5/17 Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2L (see all 17
) ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · SP1 :           -     -             -                           SP2 :   -         -     -             -                           SP3 :                                                     SP4 :                                                     SP5 :           -                 -                          
ExUns: 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31a · 31b SP1 :         -   -   -   -     -               -   -         -   -         SP2 :         -   -   -   -     -                                   SP3 :         -   -   -   -     -               -   -         -   -   -       SP4 :         -   -   -   -     -               -   -         -           SP5 :                                                    
About this scheme ECgene alternative splicing isoforms for UBAP2L 6 Ensembl transcripts including schematic representations : ENST00000271877
ENST00000361546
ENST00000368505
ENST00000343815
ENST00000368504
ENST00000310038
Expression for UBAP2L
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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UBAP2L expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for UBAP2L 1 / 2 / 3
15 probe-sets matching UBAP2L gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.490551 UniProtKB/Swiss-Prot: UBP2L_HUMAN, Q14157 Tissue specificity : Ubiquitous
Orthologs for UBAP2L
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for UBAP2L gene from 5/9 species (see all 9
)
About this table Species with no ortholog for UBAP2L ENSEMBL Gene Tree for UBAP2L Paralogs for UBAP2L (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for UBAP2L gene UBAP2 2
SNPs/Variants for UBAP2L (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for UBAP2L (up to first 250kb)
Disorders & Mutations for UBAP2L
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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--
Medical News for UBAP2L (Possibly Related Articles in
Doctor's Guide )
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--
Publications for UBAP2L (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for UBAP2L gene (see all 20
): Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PubMed id 11230159) 2, 3, 4 Marenholz I....Mischke D. (2001) Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280) 2, 3, 4 Nagase T....Nomura N. (1995) A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243) 3, 4 Beausoleil S.A.... Gygi S.P. (2006) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384) 3, 4 Tao W.A.... Aebersold R. (2005) Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455) 3, 4 Rush J.... Comb M.J. (2005) Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186) 3, 4 Brill L.M....Peters E.C. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004)
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Genome Databases showing UBAP2L
(According to
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HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing UBAP2L
(According to HUGE )
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Specialized Databases showing UBAP2L (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for UBAP2L (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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