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Aliases for UBAP2L Gene

Aliases for UBAP2L Gene

  • Ubiquitin Associated Protein 2 Like 2 3 5
  • Ubiquitin Associated Protein 2-Like 2 3
  • Protein NICE-4 3 4
  • NICE4 3 4
  • KIAA0144 4
  • NICE-4 3

External Ids for UBAP2L Gene

Previous GeneCards Identifiers for UBAP2L Gene

  • GC01P151006
  • GC01P152459
  • GC01P125556

Summaries for UBAP2L Gene

GeneCards Summary for UBAP2L Gene

UBAP2L (Ubiquitin Associated Protein 2 Like) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is UBAP2.

UniProtKB/Swiss-Prot for UBAP2L Gene

  • Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).

Gene Wiki entry for UBAP2L Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAP2L Gene

Genomics for UBAP2L Gene

Regulatory Elements for UBAP2L Gene

Promoters for UBAP2L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBAP2L on UCSC Golden Path with GeneCards custom track

Genomic Location for UBAP2L Gene

154,219,951 bp from pter
154,271,510 bp from pter
51,560 bases
Plus strand

Genomic View for UBAP2L Gene

Genes around UBAP2L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBAP2L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBAP2L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAP2L Gene

Proteins for UBAP2L Gene

  • Protein details for UBAP2L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ubiquitin-associated protein 2-like
    Protein Accession:
    Secondary Accessions:
    • B4E0U8
    • Q5VU75
    • Q5VU76
    • Q9BTU3
    • Q9UGL2
    • Q9UGL3
    • Q9UGL4
    • Q9UGL5

    Protein attributes for UBAP2L Gene

    1087 amino acids
    Molecular mass:
    114535 Da
    Quaternary structure:
    • Interacts with BMI1 (PubMed:25185265). Part of a complex consisting of UBAP2L, BMI1 and RNF2(PubMed:25185265).
    • Sequence=CAB65100.2; Type=Frameshift; Positions=1085; Evidence={ECO:0000305};

    Alternative splice isoforms for UBAP2L Gene


neXtProt entry for UBAP2L Gene

Proteomics data for UBAP2L Gene at MOPED

Post-translational modifications for UBAP2L Gene

No data available for DME Specific Peptides for UBAP2L Gene

Domains & Families for UBAP2L Gene

Protein Domains for UBAP2L Gene

Suggested Antigen Peptide Sequences for UBAP2L Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 UBA domain.
  • Contains 1 UBA domain.
genes like me logo Genes that share domains with UBAP2L: view

No data available for Gene Families for UBAP2L Gene

Function for UBAP2L Gene

Molecular function for UBAP2L Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in the activity of long-term repopulating hematopoietic stem cells (LT-HSCs).
genes like me logo Genes that share phenotypes with UBAP2L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBAP2L Gene

Localization for UBAP2L Gene

Subcellular locations from

Jensen Localization Image for UBAP2L Gene COMPARTMENTS Subcellular localization image for UBAP2L gene
Compartment Confidence
nucleus 5
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBAP2L Gene

Pathways & Interactions for UBAP2L Gene

SuperPathways for UBAP2L Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBAP2L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0061484 hematopoietic stem cell homeostasis IEA,IGI 25185265
genes like me logo Genes that share ontologies with UBAP2L: view

No data available for Pathways by source and SIGNOR curated interactions for UBAP2L Gene

Drugs & Compounds for UBAP2L Gene

No Compound Related Data Available

Transcripts for UBAP2L Gene

Unigene Clusters for UBAP2L Gene

Ubiquitin associated protein 2-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2L Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a ·
SP1: - - -
SP2: - - - -
SP5: - -
SP6: -
SP8: -

ExUns: 20b · 20c ^ 21a · 21b · 21c · 21d ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c ^ 26 ^ 27a · 27b ^ 28a · 28b · 28c ^ 29 ^ 30 ^ 31a · 31b
SP1: - - - - - - - - -
SP2: - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - -
SP7: - - - - - - -
SP9: - - -
SP10: - -
SP11: - - - -
SP14: - - - - -
SP16: -

Relevant External Links for UBAP2L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UBAP2L Gene

mRNA expression in normal human tissues for UBAP2L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBAP2L Gene

This gene is overexpressed in Bone marrow stromal cell (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBAP2L Gene

SOURCE GeneReport for Unigene cluster for UBAP2L Gene Hs.490551

mRNA Expression by UniProt/SwissProt for UBAP2L Gene

Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with UBAP2L: view

Protein tissue co-expression partners for UBAP2L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBAP2L Gene

Orthologs for UBAP2L Gene

This gene was present in the common ancestor of animals.

Orthologs for UBAP2L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia UBAP2L 35
  • 96.18 (n)
  • 98.66 (a)
  • 98 (a)
(Pan troglodytes)
Mammalia UBAP2L 35
  • 99.82 (n)
  • 99.91 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Atp8b2 35
  • 94.44 (n)
  • 98.11 (a)
(Canis familiaris)
Mammalia UBAP2L 36
  • 98 (a)
(Monodelphis domestica)
Mammalia UBAP2L 36
  • 96 (a)
(Mus musculus)
Mammalia Ubap2l 36
  • 96 (a)
(Gallus gallus)
Aves UBAP2L 36
  • 88 (a)
(Anolis carolinensis)
Reptilia UBAP2L 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ubap2l 35
  • 71.46 (n)
  • 77.12 (a)
Str.5318 35
(Danio rerio)
Actinopterygii ubap2l 36
  • 61 (a)
fruit fly
(Drosophila melanogaster)
Insecta lig 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
CSA.1157 36
  • 36 (a)
Species with no ortholog for UBAP2L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAP2L Gene

Gene Tree for UBAP2L (if available)
Gene Tree for UBAP2L (if available)

Paralogs for UBAP2L Gene

Paralogs for UBAP2L Gene

(1) SIMAP similar genes for UBAP2L Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with UBAP2L: view

Variants for UBAP2L Gene

Sequence variations from dbSNP and Humsavar for UBAP2L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17849745 - 154,251,273(+) GCTCA(C/G)CAGAA reference, missense
rs715737 -- 154,264,094(-) GAGAT(A/G)TCTGA intron-variant
rs1194580 -- 154,247,009(-) GATGT(A/C)GTTAA intron-variant
rs1194581 -- 154,243,605(-) cacac(A/G)cctgt intron-variant
rs1194582 -- 154,243,497(-) GCCGA(A/C/T)ACAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBAP2L Gene

Variant ID Type Subtype PubMed ID
nsv2954 CNV Insertion 18451855
esv2672763 CNV Deletion 23128226
nsv521887 CNV Gain 19592680

Variation tolerance for UBAP2L Gene

Residual Variation Intolerance Score: 2.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBAP2L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBAP2L Gene

Disorders for UBAP2L Gene

Relevant External Links for UBAP2L

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for UBAP2L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBAP2L Gene

Publications for UBAP2L Gene

  1. Identification of human epidermal differentiation complex (EDC)- encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library. (PMID: 11230159) Marenholz I. … Mischke D. (Genome Res. 2001) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 8590280) Nagase T. … Nomura N. (DNA Res. 1995) 2 3
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3

Products for UBAP2L Gene

Sources for UBAP2L Gene

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