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Aliases & Descriptions for UBAP2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ22435 1, 2 | | FLJ43947 2 | | FLJ46567 2 | | KIAA1491 1, 2, 3 | | OTTHUMP00000000473 2 | | OTTHUMP00000000476 2 | | bA176F3.5 1, 2 |
| | | Descriptions |
|---|
| AD-012 protein 2 | | ubiquitin associated protein 2 2 |
|
| | Search outside databases for aliases for UBAP2 genePrevious GC identifers: GC09M034234 GC09M034091 |
Summaries for UBAP2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for UBAP2: This gene is a novel gene isolated based on its expression in the human adrenal gland. The full-length protein encoded by this gene contains a UBA-domain (ubiquitin associated domain), which is a motif found in several proteins having connections to ubiquitin and the ubiquitination pathway. In addition, the protein contains a region similar to a domain found in members of the atrophin-1 family. The function of this protein has not been determined. Additional alternate splice variants may exist, but their full length nature has not been determined. [provided by RefSeq] Gene Wiki entry for UBAP2 |
Genomic Location for UBAP2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p11.2UBAP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M033911:
(about GC identifiers)
Start:
|
33,911,691 bp from pter |
End:
|
34,038,947 bp from pter |
Size:
|
127,257 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008413.17
| Proteins for UBAP2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: UBAP2_HUMAN, Q5T6F2 (See
protein sequence)Recommended Name: Ubiquitin-associated protein 2 Size: 1119 amino acids; 117116 Da
Secondary accessions: Q2M2R4 Q6PK34 Q8NC94 Q9P237Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060919.2
ENSEMBL proteins: ENSP00000368562 ENSP00000368527 ENSP00000368541 ENSP00000368537 ENSP00000354039 ENSP00000368540 ENSP00000259602
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for UBAP2: Assays for UBAP2: | Protein
Domains/ Families for UBAP2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q5T6F2
ProtoNet protein and cluster: Q5T6F2 UniProtKB/Swiss-Prot: UBAP2_HUMAN, Q5T6F2Similarity: Contains 1 UBA domain | Gene Function for UBAP2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_018449
Applied Biosystems Silencer® siRNAs for UBAP2
Sigma-Aldrich siRNA and siRNA Panels for UBAP2  Sigma-Aldrich shRNA for UBAP2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018449                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018449                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018449 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018449
| Pathways & Interactions for UBAP2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| -- |
Drugs & Compounds for UBAP2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for UBAP2
|
Transcripts for UBAP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_018449
Sigma-Aldrich siRNA and siRNA Panels for UBAP2  Sigma-Aldrich shRNA for UBAP2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018449 REFSEQ mRNAs for UBAP2 gene: NM_018449.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018449               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018449                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018449                                  untagged cDNA clones in CMV expression vector (see all 2): NM_018449  Additional cDNA sequence: AB040924.1 AB209911.1 AK025357.1 AK025801.1 AK026088.1 AK074884.1 AK125935.1 AK128424.1 AK294952.1 AK299183.1 AK302335.1 AK302754.1 AK303493.1 AY358682.1 BC007890.2 BC037416.1 BC041077.1 BC111409.1 BC111762.1 CR933678.1 24/28 DOTS entries (see all 28
): DT.114599 DT.91746604 DT.95284016 DT.101983022 DT.86858408 DT.91731651 DT.100817397 DT.91879021 DT.97852025 DT.40260725 DT.95284010 DT.100817398 DT.121144572 DT.100037520 DT.121144590 DT.121144597 DT.91746606 DT.95109829 DT.121144576 DT.121144609 DT.121144621 DT.91652440 DT.91728070 DT.91746603 24/221 AceView cDNA sequences (see all 221
):BX482127 BU153229 BC007890 BC041077 BQ935283 NM_020867 AI560344 BU155450 AK026088 CA843092 AB040924 NM_018449 AK025801 NM_148171 AW851531 Z38981 BQ670068 BU156954 BM662784 BQ944952 AK128424 BP873074 CA943719 AL705158
highest scoring ESTs for UBAP2:BG723831 BM840452 BM840584 R54455 AA086486 AA112774 AA150077 AA262689 AA345490 AA452282 Unigene Cluster for UBAP2: Ubiquitin associated protein 2 Hs.493739 [show with all ESTs]Unigene Representative Sequence: AB209911
GeneLoc Exon Structure
5/25 Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2 (see all 25
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c | · | 14d | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 14e | ^ | 15a | · | 15b | · | 15c | · | 15d | · | 15e | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | ^ | 21 | ^ | 22a | · | 22b | · | 22c | · | 22d | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26a | · | 26b | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | - |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   |
| ExUns: | 26c | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30 | ^ | 31 | ^ | 32 | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for UBAP2
7 Ensembl transcripts including schematic representations: ENST00000379260
ENST00000379225
ENST00000379239
ENST00000379235
ENST00000360802
ENST00000379238
ENST00000351580
|
Expression for UBAP2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| UBAP2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for UBAP2
1 / 2 / 3 5 probe-sets matching UBAP2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCTCTGTGGG
SOURCE GeneReport for Unigene cluster: Hs.493739
|
Orthologs for UBAP2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for UBAP2 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for UBAP2
ENSEMBL Gene Tree for UBAP2 | Paralogs for UBAP2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for UBAP2 gene
- UBAP2L2
|
SNPs/Variants for UBAP2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for UBAP2 (up to first 250kb)
|
Disorders & Mutations for UBAP2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| -- |
Medical News for UBAP2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for UBAP2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/13 PubMed articles for UBAP2 gene (see all 13
):- Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)3, 4 Zhang Y.... White F.M. (2005)
- Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)3, 4 Rush J.... Comb M.J. (2005)
- Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)3, 4 Brill L.M....Peters E.C. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)3, 4 Humphray S.J.... Dunham I. (2004)
- Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)3, 4 Nagase T....Ohara O. (2000)
- The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. (PubMed id 8871400)2, 3 Hofmann K. and Bucher P. (1996)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332)4 Matsuoka S.... Elledge S.J. (2007)
|
Search for UBAP2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing UBAP2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing UBAP2
(According to HUGE)
About This Section
| |
Specialized Databases showing UBAP2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for UBAP2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for UBAP2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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