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Aliases for UBAP2 Gene

Aliases for UBAP2 Gene

  • Ubiquitin Associated Protein 2 2 3 5
  • UBAP-2 3 4
  • Ubiquitin-Associated Protein 2 3
  • AD-012 Protein 3
  • KIAA1491 4

External Ids for UBAP2 Gene

Previous GeneCards Identifiers for UBAP2 Gene

  • GC09M034234
  • GC09M034091
  • GC09M033911
  • GC09M033879

Summaries for UBAP2 Gene

Entrez Gene Summary for UBAP2 Gene

  • The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for UBAP2 Gene

UBAP2 (Ubiquitin Associated Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is UBAP2L.

Gene Wiki entry for UBAP2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAP2 Gene

Genomics for UBAP2 Gene

Regulatory Elements for UBAP2 Gene

Enhancers for UBAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G033749 1.3 Ensembl ENCODE dbSUPER 10.5 +297.0 297029 4.2 SOX13 TFAP4 FOXA2 SAP130 ARID4B MAX CEBPG YY1 EGR1 NCOR1 ENSG00000260947 TRBV26OR9-2 RNU4ATAC11P UBE2R2 UBAP2 LINC01251 PRSS3 ENSG00000227301 NOL6 TRBV29OR9-2
GH09G034071 1.2 Ensembl ENCODE 11.3 -24.1 -24145 3.0 HNRNPUL1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF121 ZNF143 FOS UBAP2 RNU4ATAC11P DCAF12 IMPDH1P1 SNORD121A ENSG00000260947 UBE2R2 ENSG00000228352 RN7SKP114
GH09G033835 1.2 Ensembl ENCODE dbSUPER 10.8 +212.7 212667 2.2 ZNF211 MTA2 ZBED1 MAX JUNB CEBPB CEBPG EP300 EED CEBPA SNORD121B UBAP2 SNORD121A UBE2R2 NUDT2 KIF24 C9orf24 ENSG00000200834 GC09P034046
GH09G033852 1.1 Ensembl ENCODE dbSUPER 10.7 +196.6 196648 0.6 HDGF CTCF STAT1 ZNF654 REST RAD21 GATA3 SMC3 HNF4A UBE2R2 SNORD121B UBAP2 SNORD121A DCAF12 GC09P034046 ENSG00000200834
GH09G033880 0.9 Ensembl dbSUPER 11.1 +168.0 168049 0.2 ZNF263 ZFHX2 HINFP ZNF600 ZNF398 ZIC2 ZBTB17 EGR2 UBE2R2 SNORD121B UBAP2 SNORD121A ENSG00000228352 RNU2-50P RNU4ATAC11P GC09M033934
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBAP2 on UCSC Golden Path with GeneCards custom track

Promoters for UBAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000234470 149 2401 PKNOX1 CREB3L1 MLX ARNT WRNIP1 ARID4B SIN3A DMAP1 FEZF1 ZNF2

Genomic Location for UBAP2 Gene

Chromosome:
9
Start:
33,921,693 bp from pter
End:
34,048,949 bp from pter
Size:
127,257 bases
Orientation:
Minus strand

Genomic View for UBAP2 Gene

Genes around UBAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAP2 Gene

Proteins for UBAP2 Gene

  • Protein details for UBAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6F2-UBAP2_HUMAN
    Recommended name:
    Ubiquitin-associated protein 2
    Protein Accession:
    Q5T6F2
    Secondary Accessions:
    • Q2M2R4
    • Q5JV03
    • Q6PK34
    • Q8NC94
    • Q9P237

    Protein attributes for UBAP2 Gene

    Size:
    1119 amino acids
    Molecular mass:
    117116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI11763.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11266.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UBAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBAP2 Gene

Post-translational modifications for UBAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UBAP2 Gene

Domains & Families for UBAP2 Gene

Protein Domains for UBAP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with UBAP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for UBAP2 Gene

Function for UBAP2 Gene

Gene Ontology (GO) - Molecular Function for UBAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with UBAP2: view
genes like me logo Genes that share phenotypes with UBAP2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBAP2 Gene

Localization for UBAP2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBAP2 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for UBAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with UBAP2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBAP2 Gene

Pathways & Interactions for UBAP2 Gene

SuperPathways for UBAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010628 positive regulation of gene expression IBA --
genes like me logo Genes that share ontologies with UBAP2: view

No data available for Pathways by source and SIGNOR curated interactions for UBAP2 Gene

Drugs & Compounds for UBAP2 Gene

No Compound Related Data Available

Transcripts for UBAP2 Gene

Unigene Clusters for UBAP2 Gene

Ubiquitin associated protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d ·
SP1: - - -
SP2:
SP3:
SP4: - - - -
SP5:
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9:
SP10:
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14:
SP15:
SP16:
SP17: - - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22:
SP23: - - - - -
SP24: -
SP25:

ExUns: 14e ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ·
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: - - - - - -
SP10:
SP11:
SP12: -
SP13:
SP14: - - - - -
SP15: - -
SP16:
SP17:
SP18:
SP19: - - - - - -
SP20: - - - -
SP21:
SP22:
SP23: -
SP24:
SP25:

ExUns: 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for UBAP2 Gene

GeneLoc Exon Structure for
UBAP2
ECgene alternative splicing isoforms for
UBAP2

Expression for UBAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBAP2 Gene

Protein differential expression in normal tissues from HIPED for UBAP2 Gene

This gene is overexpressed in Testis (16.3), Pancreas (15.7), CD8 Tcells (9.4), and Fetal testis (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBAP2 Gene



Protein tissue co-expression partners for UBAP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBAP2 Gene:

UBAP2

SOURCE GeneReport for Unigene cluster for UBAP2 Gene:

Hs.493739

Evidence on tissue expression from TISSUES for UBAP2 Gene

  • Nervous system(3.8)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with UBAP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBAP2 Gene

Orthologs for UBAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBAP2 34 35
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia UBAP2 34 35
  • 89.41 (n)
cow
(Bos Taurus)
Mammalia UBAP2 34 35
  • 87.38 (n)
mouse
(Mus musculus)
Mammalia Ubap2 34 16 35
  • 83.92 (n)
rat
(Rattus norvegicus)
Mammalia Ubap2 34
  • 82.56 (n)
oppossum
(Monodelphis domestica)
Mammalia UBAP2 35
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBAP2 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC407092 34
  • 74.82 (n)
-- 35
  • 71 (a)
OneToMany
-- 35
  • 69 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia UBAP2 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubap2 34
  • 69.7 (n)
Str.8950 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.33004 34
zebrafish
(Danio rerio)
Actinopterygii ubap2 34 35
  • 59.72 (n)
UBAP2 (1 of 2) 35
  • 45 (a)
OneToMany
wufb19h07 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7126 34
fruit fly
(Drosophila melanogaster)
Insecta lig 35
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1157 35
  • 32 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
Species where no ortholog for UBAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAP2 Gene

ENSEMBL:
Gene Tree for UBAP2 (if available)
TreeFam:
Gene Tree for UBAP2 (if available)

Paralogs for UBAP2 Gene

Paralogs for UBAP2 Gene

genes like me logo Genes that share paralogs with UBAP2: view

Variants for UBAP2 Gene

Sequence variations from dbSNP and Humsavar for UBAP2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000007363 -- 34,017,843(+) AATGG(C/T)GTGAA intron-variant
rs1000038323 -- 34,018,321(+) ACACT(A/C/G)TAATT intron-variant
rs1000039260 -- 34,023,979(+) CGGAG(-/T)TCTGC intron-variant
rs1000073711 -- 33,930,921(+) AAAGC(A/G)GATGA intron-variant
rs1000080939 -- 33,978,325(+) GCCAC(A/G)GTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBAP2 Gene

Variant ID Type Subtype PubMed ID
esv2664507 CNV deletion 23128226
esv2675724 CNV deletion 23128226
esv2738380 CNV deletion 23290073
esv2738381 CNV deletion 23290073
esv2738382 CNV deletion 23290073
esv3620335 CNV gain 21293372
esv3620339 CNV gain 21293372
esv3620340 CNV loss 21293372
esv3620341 CNV gain 21293372
nsv1023129 CNV gain 25217958
nsv1030732 CNV gain 25217958
nsv1117873 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259
nsv1128471 CNV deletion 24896259
nsv520467 CNV gain 19592680
nsv614153 CNV loss 21841781
nsv614154 CNV loss 21841781
nsv6525 CNV deletion 18451855
nsv831541 CNV loss 17160897
nsv968609 CNV duplication 23825009

Variation tolerance for UBAP2 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.06; 90.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBAP2 Gene

Human Gene Mutation Database (HGMD)
UBAP2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBAP2 Gene

Disorders for UBAP2 Gene

Relevant External Links for UBAP2

Genetic Association Database (GAD)
UBAP2
Human Genome Epidemiology (HuGE) Navigator
UBAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBAP2

No disorders were found for UBAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBAP2 Gene

Publications for UBAP2 Gene

  1. Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration? (PMID: 20670673) Venturelli E. … Galimberti D. (Neurosci. Lett. 2010) 3 46 64
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill L.M. … Peters E.C. (Anal. Chem. 2004) 3 4 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for UBAP2 Gene

Sources for UBAP2 Gene

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