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Aliases for UBAP2 Gene

Aliases for UBAP2 Gene

  • Ubiquitin Associated Protein 2 2 3 5
  • UBAP-2 3 4
  • AD-012 Protein 3
  • KIAA1491 4

External Ids for UBAP2 Gene

Previous GeneCards Identifiers for UBAP2 Gene

  • GC09M034234
  • GC09M034091
  • GC09M033911
  • GC09M033879

Summaries for UBAP2 Gene

Entrez Gene Summary for UBAP2 Gene

  • The protein encoded by this gene contains a UBA (ubiquitin associated) domain, which is characteristic of proteins that function in the ubiquitination pathway. This gene may show increased expression in the adrenal gland and lymphatic tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for UBAP2 Gene

UBAP2 (Ubiquitin Associated Protein 2) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding. An important paralog of this gene is UBAP2L.

Gene Wiki entry for UBAP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAP2 Gene

Genomics for UBAP2 Gene

Regulatory Elements for UBAP2 Gene

Promoters for UBAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for UBAP2 Gene

Chromosome:
9
Start:
33,921,693 bp from pter
End:
34,048,949 bp from pter
Size:
127,257 bases
Orientation:
Minus strand

Genomic View for UBAP2 Gene

Genes around UBAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAP2 Gene

Proteins for UBAP2 Gene

  • Protein details for UBAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6F2-UBAP2_HUMAN
    Recommended name:
    Ubiquitin-associated protein 2
    Protein Accession:
    Q5T6F2
    Secondary Accessions:
    • Q2M2R4
    • Q5JV03
    • Q6PK34
    • Q8NC94
    • Q9P237

    Protein attributes for UBAP2 Gene

    Size:
    1119 amino acids
    Molecular mass:
    117116 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI11763.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11266.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for UBAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for UBAP2 Gene

Proteomics data for UBAP2 Gene at MOPED

Post-translational modifications for UBAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for UBAP2 Gene

Domains & Families for UBAP2 Gene

Protein Domains for UBAP2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5T6F2

UniProtKB/Swiss-Prot:

UBAP2_HUMAN :
  • Contains 1 UBA domain.
Domain:
  • Contains 1 UBA domain.
genes like me logo Genes that share domains with UBAP2: view

No data available for Gene Families for UBAP2 Gene

Function for UBAP2 Gene

genes like me logo Genes that share phenotypes with UBAP2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UBAP2 Gene

Localization for UBAP2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBAP2 Gene COMPARTMENTS Subcellular localization image for UBAP2 gene
Compartment Confidence
cytosol 3
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for UBAP2 Gene

Pathways & Interactions for UBAP2 Gene

SuperPathways for UBAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for UBAP2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for UBAP2 Gene

Drugs & Compounds for UBAP2 Gene

No Compound Related Data Available

Transcripts for UBAP2 Gene

Unigene Clusters for UBAP2 Gene

Ubiquitin associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d ·
SP1: - - -
SP2:
SP3:
SP4: - - - -
SP5:
SP6: - - - - - - - - - - - - - -
SP7: - - - - - - - -
SP8: - - -
SP9:
SP10:
SP11: - - - - - - - - - - - - - - - - - -
SP12: - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - - - - - -
SP14:
SP15:
SP16:
SP17: - - -
SP18: - - - -
SP19:
SP20:
SP21:
SP22:
SP23: - - - - -
SP24: -
SP25:

ExUns: 14e ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ·
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: - - - - - -
SP10:
SP11:
SP12: -
SP13:
SP14: - - - - -
SP15: - -
SP16:
SP17:
SP18:
SP19: - - - - - -
SP20: - - - -
SP21:
SP22:
SP23: -
SP24:
SP25:

ExUns: 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for UBAP2 Gene

GeneLoc Exon Structure for
UBAP2
ECgene alternative splicing isoforms for
UBAP2

Expression for UBAP2 Gene

mRNA expression in normal human tissues for UBAP2 Gene

Protein differential expression in normal tissues from HIPED for UBAP2 Gene

This gene is overexpressed in Testis (16.3), Pancreas (15.7), CD8 Tcells (9.4), and Fetal testis (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBAP2 Gene



SOURCE GeneReport for Unigene cluster for UBAP2 Gene Hs.493739

genes like me logo Genes that share expression patterns with UBAP2: view

Protein tissue co-expression partners for UBAP2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for UBAP2 Gene

Orthologs for UBAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for UBAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBAP2 36
  • 99 (a)
OneToOne
UBAP2 35
  • 99.29 (n)
  • 98.66 (a)
cow
(Bos Taurus)
Mammalia UBAP2 36
  • 84 (a)
OneToOne
UBAP2 35
  • 87.38 (n)
  • 86.84 (a)
dog
(Canis familiaris)
Mammalia UBAP2 35
  • 89.41 (n)
  • 89.62 (a)
UBAP2 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ubap2 16
Ubap2 35
  • 83.92 (n)
  • 81.22 (a)
Ubap2 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia UBAP2 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBAP2 36
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ubap2 35
  • 82.56 (n)
  • 79.73 (a)
chicken
(Gallus gallus)
Aves LOC407092 35
  • 74.82 (n)
  • 74.7 (a)
-- 36
  • 69 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia UBAP2 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33004 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8950 35
ubap2 35
  • 69.7 (n)
  • 69.13 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7126 35
zebrafish
(Danio rerio)
Actinopterygii ubap2 36
  • 51 (a)
OneToMany
UBAP2 (1 of 2) 36
  • 45 (a)
OneToMany
ubap2 35
  • 59.72 (n)
  • 57.93 (a)
wufb19h07 35
fruit fly
(Drosophila melanogaster)
Insecta lig 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
ManyToMany
CSA.1157 36
  • 32 (a)
ManyToMany
Species with no ortholog for UBAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAP2 Gene

ENSEMBL:
Gene Tree for UBAP2 (if available)
TreeFam:
Gene Tree for UBAP2 (if available)

Paralogs for UBAP2 Gene

Paralogs for UBAP2 Gene

genes like me logo Genes that share paralogs with UBAP2: view

Variants for UBAP2 Gene

Sequence variations from dbSNP and Humsavar for UBAP2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs307658 - 33,941,761(-) ACTGA(A/G)TTCTG reference, missense
rs307692 - 33,927,901(-) AGGCG(C/T)CAGCC reference, missense, utr-variant-5-prime
rs1785506 - 34,017,108(-) TGCTC(A/G)GGAAA intron-variant, reference, missense
rs10971809 - 33,944,624(+) GCTCA(A/C/G)GTTGA reference, missense
rs16935295 - 33,927,882(+) GTGTT(C/G)ATGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for UBAP2 Gene

Variant ID Type Subtype PubMed ID
nsv893028 CNV Gain 21882294
nsv520467 CNV Gain 19592680
nsv831541 CNV Loss 17160897
nsv893030 CNV Gain 21882294
nsv893031 CNV Loss 21882294
nsv893032 CNV Loss 21882294
esv2675724 CNV Deletion 23128226
nsv893033 CNV Gain 21882294
esv2738380 CNV Deletion 23290073
esv2738381 CNV Deletion 23290073
esv2738382 CNV Deletion 23290073
esv2664507 CNV Deletion 23128226
nsv6525 CNV Loss 18451855

Variation tolerance for UBAP2 Gene

Residual Variation Intolerance Score: 75.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.06; 90.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBAP2 Gene

HapMap Linkage Disequilibrium report
UBAP2
Human Gene Mutation Database (HGMD)
UBAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBAP2 Gene

Disorders for UBAP2 Gene

Relevant External Links for UBAP2

Genetic Association Database (GAD)
UBAP2
Human Genome Epidemiology (HuGE) Navigator
UBAP2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBAP2

No disorders were found for UBAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBAP2 Gene

Publications for UBAP2 Gene

  1. Is KIF24 a genetic risk factor for Frontotemporal Lobar Degeneration? (PMID: 20670673) Venturelli E. … Galimberti D. (Neurosci. Lett. 2010) 3 48 67
  2. The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. (PMID: 8871400) Hofmann K. … Bucher P. (Trends Biochem. Sci. 1996) 2 3
  3. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  4. Analysis of HIV-1 Gag protein interactions via biotin ligase tagging. (PMID: 25631074) Ritchie C. … Barklis E. (J. Virol. 2015) 3
  5. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3

Products for UBAP2 Gene

Sources for UBAP2 Gene

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