V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

UBAP2 Gene

protein-coding   GIFtS: 43

GC09M033911
ubiquitin associated protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FLJ22435 1, 2
FLJ43947 2
FLJ46567 2
KIAA1491 1, 2, 3
OTTHUMP00000000473 2
OTTHUMP00000000476 2
bA176F3.5 1, 2
Descriptions
AD-012 protein 2
ubiquitin associated protein 2 2
External Ids
HGNC: 141851
Entrez Gene: 558332
UniProtKB: Q5T6F23
Ensembl: ENSG000001370737
Search outside databases for aliases for UBAP2 gene

Previous GC identifers: GC09M034234 GC09M034091

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for UBAP2:
This gene is a novel gene isolated based on its expression in the human adrenal gland. The
full-length protein encoded by this gene contains a UBA-domain (ubiquitin associated domain),
which is a motif found in several proteins having connections to ubiquitin and the ubiquitination
pathway. In addition, the protein contains a region similar to a domain found in members of the
atrophin-1 family. The function of this protein has not been determined. Additional alternate
splice variants may exist, but their full length nature has not been determined. [provided by
RefSeq]

Gene Wiki entry for UBAP2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p11.2

UBAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M033911:     (about GC identifiers)

Start:
33,911,691 bp from pter
End:
34,038,947 bp from pter
Size:
127,257 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000009.10  NT_008413.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: UBAP2_HUMAN, Q5T6F2 (See protein sequence)
Recommended Name: Ubiquitin-associated protein 2  
Size: 1119 amino acids; 117116 Da
Secondary accessions: Q2M2R4 Q6PK34 Q8NC94 Q9P237

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_060919.2  

    ENSEMBL proteins: 
    ENSP00000368562 ENSP00000368527 ENSP00000368541 ENSP00000368537 ENSP00000354039 ENSP00000368540 
    ENSP00000259602 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for UBAP2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for UBAP2
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for UBAP2

    Assays for UBAP2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000449 UBA/transl_elong_EF1B_N
     IPR015940 UBA/transl_elong_EF1B_N_euk


       GeneDecks  UBAP2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5T6F2

    ProtoNet protein and cluster: Q5T6F2

    UniProtKB/Swiss-Prot: UBAP2_HUMAN, Q5T6F2
    Similarity: Contains 1 UBA domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBAP2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_018449

                  Applied Biosystems Silencer® siRNAs for UBAP2

                  Sigma-Aldrich siRNA and siRNA Panels for UBAP2  
                         Sigma-Aldrich shRNA for UBAP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018449
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018449
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_018449 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018449

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for UBAP2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (UBAP2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_018449

                  Sigma-Aldrich siRNA and siRNA Panels for UBAP2  
                         Sigma-Aldrich shRNA for UBAP2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018449  

    REFSEQ mRNAs for UBAP2 gene: 

    NM_018449.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018449  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018449
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018449
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_018449 

    Additional cDNA sequence: 

    AB040924.1 AB209911.1 AK025357.1 AK025801.1 AK026088.1 AK074884.1 AK125935.1 AK128424.1 
    AK294952.1 AK299183.1 AK302335.1 AK302754.1 AK303493.1 AY358682.1 BC007890.2 BC037416.1 
    BC041077.1 BC111409.1 BC111762.1 CR933678.1 

    24/28 DOTS entries (see all 28 ):

    DT.114599  DT.91746604  DT.95284016  DT.101983022  DT.86858408  DT.91731651  DT.100817397  DT.91879021 
    DT.97852025  DT.40260725  DT.95284010  DT.100817398  DT.121144572  DT.100037520  DT.121144590  DT.121144597 
    DT.91746606  DT.95109829  DT.121144576  DT.121144609  DT.121144621  DT.91652440  DT.91728070  DT.91746603 

    24/221 AceView cDNA sequences (see all 221 ):

    BX482127 BU153229 BC007890 BC041077 BQ935283 NM_020867 AI560344 BU155450 
    AK026088 CA843092 AB040924 NM_018449 AK025801 NM_148171 AW851531 Z38981 
    BQ670068 BU156954 BM662784 BQ944952 AK128424 BP873074 CA943719 AL705158 

    highest scoring ESTs for UBAP2:

    BG723831 BM840452 BM840584 R54455 AA086486 AA112774 AA150077 AA262689 AA345490 AA452282 

    Unigene Cluster for UBAP2:

    Ubiquitin associated protein 2
    Hs.493739  [show with all ESTs]
    Unigene Representative Sequence: AB209911


    GeneLoc Exon Structure

    5/25 Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2 (see all 25 )

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b · 14c · 14d ·
    SP1:                                                                                                              -           -           -                     
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                              -                                               -           -           -                     
    SP5:                                                                                                                                                            

    ExUns: 14e ^ 15a · 15b · 15c · 15d · 15e ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^ 21 ^ 22a · 22b · 22c · 22d ^ 23a · 23b ^ 24 ^ 25 ^ 26a · 26b ·
    SP1:                                                        -     -     -     -                       -     -     -     -           -                 -         
    SP2:                                                                                                  -     -     -     -           -                 -         
    SP3:                                                                                                                                -                 -         
    SP4:                                                                                                                                                            
    SP5:                                                                                                  -                             -                 -         

    ExUns: 26c ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31 ^ 32
    SP1:                          -                     
    SP2:                          -                     
    SP3:                          -                     
    SP4:                                                
    SP5:                                                

    About this scheme

    ECgene alternative splicing isoforms for UBAP2

    7 Ensembl transcripts including schematic representations:
    ENST00000379260  ENST00000379225  ENST00000379239  ENST00000379235  ENST00000360802  ENST00000379238  
    ENST00000351580  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    UBAP2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for UBAP2

    1 / 2 / 3

    5 probe-sets matching UBAP2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    53865_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 R54455 0.80 1.00 0.91 1

    219192_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018449 0.60 1.00 0.82 1

    221839_s_at2, 3 U133-A 1 1.00 1.00 -- -- AK026088 0.60 1.00 0.82 1

    219192_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    221839_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CCTCTGTGGG

    SOURCE GeneReport for Unigene cluster: Hs.493739
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for UBAP2 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    UBAP21   -- ubiquitin associated protein 2 90.29(n)
    90.62(a)
    481583  XM_860520.1  XP_865613.1 
    chimpanzee
    (Pan troglodytes)
    UBAP21   -- ubiquitin associated protein 2 99.26(n)
    98.57(a)
    473216  XM_528586.2  XP_528586.2 
    rat
    (Rattus norvegicus)
    Ubap21   -- ubiquitin-associated protein 2 83.47(n)
    81.7(a)
    313169  XM_232901.4  XP_232901.4 
    mouse
    (Mus musculus)
    Ubap21, 5 45
    ubiquitin-associated protein 21, 5 84.79(n)1
    82.21(a)1
    689261  NM_026872.11  NP_081148.11 
     AA4086005  AF2769655  (see all 18)
    chicken
    (Gallus gallus)
    UBAP21   -- ubiquitin associated protein 2 73.03(n)
    71.88(a)
    407091  XM_001236333.1  XP_001236334.1 
    About this table        Species with no ortholog for UBAP2

    ENSEMBL Gene Tree for UBAP2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for UBAP2 gene
    UBAP2L2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1011 NCBI SNPs in UBAP2 are shown (see all 1011 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 191)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs3076581,2
    A,C,F,H,O33931759(-) ACTGAA/GTTCTG 1 N/S mis1 ese317Minor allele frequency- T:0.01MN NA EA EU WA 2970
    rs27811,2
    A,C,F,H,O33911977(+) CAGATG/CAAGAT 1 -- ut31 ese324Minor allele frequency- C:0.34MN EA NA EU WA 3714
    rs17855061,2
    A,C,F,H,O34007106(-) TGCTCA/GGGAAA 1 R/Q mis1 ese313Minor allele frequency- G:0.31EA EU WA NA 1938
    rs123761451,2
    A,C,F,H34040406(+) CCCATC/TGGGCC 1 -- ng314Minor allele frequency- T:0.03EU EA WA 418
    rs101154071,2
    A,C,F,H34040307(+) CACTTC/AACCGG 1 -- ng31 tfbs311Minor allele frequency- A:0.10EU EA WA NA 978
    rs118481,2
    C,F,H,O33911919(-) TTCATA/GTAGAA 1 -- ut31 ese317Minor allele frequency- G:0.26MN EU EA WA NA 1724
    rs22771781,2
    C,F,H33911933(+) AAACAG/AGTGGC 1 -- ut31 ese312Minor allele frequency- A:0.15EA NA EU WA 2472
    rs3076921,2
    A,C,H33917899(-) AGGCGT/CCAGCC 1 V/A mis1 ese34Minor allele frequency- C:0.00EU EA WA 418
    rs169352951,2
    C,F,H33917880(+) GTGTTC/GATGCT 1 M/I mis1 ese311Minor allele frequency- G:0.02NA EU EA WA 968
    rs101224951,2
    C,F,H34039779(+) GGATTA/TAAAAA 1 -- ng31 tfbs33Minor allele frequency- T:0.22EA WA 288
    About this table

    HapMap Linkage Disequilibrium images for UBAP2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for UBAP2 gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55833 HGNC: 14185 AceView: UBAP2 Ensembl:ENSG00000137073 euGenes: HUgn55833
    ECgene: UBAP2 H-InvDB: UBAP2
    (According to HUGE)
    About This Section

    HUGE: KIAA1491
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for UBAP2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for UBAP2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for UBAP2 Antibodies for UBAP2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for UBAP2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Search for Antibodies
     Search for Chimera RNAi
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Search for Recombinant Proteins
     Search for Antibodies
     Search OriGene for UBAP2
     Search Tocris compounds for UBAP2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for UBAP2

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    UBAP2 Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com