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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

UBAP2 Gene

protein-coding GIFtS: 50
GCID: GC09M033921

ubiquitin associated protein 2

Explore 1 disease affiliated with
UBAP2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ubiquitin Associated Protein 2¹ ²		FLJ22435¹
BA176F3.5¹		AD-012 Protein²
KIAA1491¹ ³		Ubiquitin-Associated Protein 2²
UBAP-2² ³

External Ids:	HGNC: 14185¹	Entrez Gene: 55833²	Ensembl: ENSG00000137073⁷	UniProtKB: Q5T6F2³

Export aliases for UBAP2 gene to outside databases

Previous GC identifers: GC09M034234 GC09M034091 GC09M033911 GC09M033879

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for UBAP2:

This gene is a novel gene isolated based on its expression in the human adrenal gland. The full-length protein encoded

by this gene contains a UBA-domain (ubiquitin associated domain), which is a motif found in several proteins having

connections to ubiquitin and the ubiquitination pathway. In addition, the protein contains a region similar to a

domain found in members of the atrophin-1 family. The function of this protein has not been determined. Additional

alternate splice variants may exist, but their full length nature has not been determined. (provided by RefSeq, Jul

2008)

Gene Wiki entry for UBAP2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for UBAP2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: UBAP2 promoter sequence

Search SABiosciences Chromatin IP Primers for UBAP2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBAP2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p11.2

UBAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBAP2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M033921: view genomic region (about GC identifiers)

Start:	33,921,691 bp from pter	End:	34,048,947 bp from pter
Size:	127,257 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: UBAP2_HUMAN, Q5T6F2 (See protein sequence)

Recommended Name: Ubiquitin-associated protein 2

Size: 1119 amino acids; 117116 Da

Sequence caution: Sequence=AAI11763.1; Type=Erroneous initiation; Sequence=BAC11266.1; Type=Erroneous initiation;

Secondary accessions: Q2M2R4 Q6PK34 Q8NC94 Q9P237

Explore the universe of human proteins at neXtProt for UBAP2: NX_Q5T6F2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5T6F2

UBAP2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060919.2

ENSEMBL proteins:

ENSP00000368540 ENSP00000368537 ENSP00000433983 ENSP00000368527 ENSP00000414800

ENSP00000412954 ENSP00000416932 ENSP00000354039 ENSP00000439329 ENSP00000368541

ENSP00000404436

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	Uscn ELISAs and CLIAs for UBAP2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

UBAP2 for domains About GeneDecksing

4 InterPro domains/families:

IPR000449 UBA/transl_elong_EF1B_N

IPR015940 UBA/transl_elong_EF1B_N_euk

IPR009060 UBA-like

IPR022166 DUF3697_Uba2

Graphical View of Domain Structure for InterPro Entry Q5T6F2

ProtoNet protein and cluster: Q5T6F2

UniProtKB/Swiss-Prot: UBAP2_HUMAN, Q5T6F2

Similarity: Contains 1 UBA domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA Products:		miRTarBase miRNAs that target UBAP2: hsa-mir-122 (MIRT003091)

		OriGene 3'-UTR Clone: UBAP2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat UBAP2
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		hsa-miR-549 hsa-miR-323-3p hsa-miR-1263 hsa-miR-520d-5p hsa-miR-548v hsa-miR-373* hsa-miR-4314 hsa-miR-4330

		SwitchGear 3'UTR luciferase reporter plasmid: UBAP2 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for UBAP2

1 GenomeRNAi human phenotype for UBAP2:

Increased circadian period len

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for UBAP2

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for UBAP2 (Q5T6F2³ ENSP00000354039⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITCH	Q96J02³, ENSP00000363998⁴	I2D: score=2 STRING: ENSP00000363998
G3BP2	Q9UN86³, ENSP00000352738⁴	I2D: score=2 STRING: ENSP00000352738
PLXNB3	ENSP00000355378⁴	STRING: ENSP00000355378
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
--	ENSP00000415363⁴	STRING: ENSP00000415363

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UBAP2
Search CenterWatch for drugs/clinical trials and news about UBAP2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UBAP2 gene (2 alternative transcripts):

NM_018449.2 NM_020867.1

Unigene Cluster for UBAP2:

Ubiquitin associated protein 2

Hs.493739 [show with all ESTs]

Unigene Representative Sequence: AB209911

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000379238(uc011loc.1 uc011lod.1 uc011loe.1 uc011lof.1 uc003ztr.2)

ENST00000379235(uc003ztn.1) ENST00000474372 ENST00000488443 ENST00000379225(uc003zts.3)

ENST00000412543 ENST00000421278 ENST00000462799 ENST00000480885 ENST00000459988

ENST00000449054 ENST00000360802(uc003zto.1 uc003ztp.2 uc003ztq.1 uc011log.1)

ENST00000539807 ENST00000379239 ENST00000418786

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		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate UBAP2 (see all 18):
		hsa-miR-549 hsa-miR-323-3p hsa-miR-1263 hsa-miR-520d-5p hsa-miR-548v hsa-miR-373* hsa-miR-4314 hsa-miR-4330

		SwitchGear 3'UTR luciferase reporter plasmid: UBAP2 3' UTR sequence

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Additional cDNA sequence:

AB040924.1 AB209911.1 AK025357.1 AK025801.1 AK026088.1 AK074884.1 AK125935.1 AK128424.1

AK294952.1 AK299183.1 AK302335.1 AK302754.1 AK303493.1 AY358682.1 BC007890.2 BC037416.1

BC041077.1 BC111409.1 BC111762.1 CR933678.1

24/28 DOTS entries (see all 28):

DT.114599 DT.91746604 DT.95284016 DT.101983022 DT.86858408 DT.91731651 DT.100817397 DT.91879021

DT.97852025 DT.95284010 DT.100817398 DT.121144572 DT.40260725 DT.100037520 DT.121144590 DT.121144597

DT.91746606 DT.121144576 DT.121144609 DT.121144621 DT.91652440 DT.91728070 DT.91746603 DT.91746607

24/221 AceView cDNA sequences (see all 221):

BE514129 AI560344 BP873074 BM802676 CA843092 BU623077 AK026088 CA949907

BQ668439 BU153229 BC007890 BQ944952 BM695705 BU179093 BQ919591 NM_148171

CD300406 AK128424 BX482127 AW848008 Z38981 BG285362 AW295816 AK025801

GeneLoc Exon Structure

5/25 Alternative Splicing Database (ASD) splice patterns (SP) for UBAP2 (see all 25) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14a	·	14b	·	14c	·	14d	·
SP1:																																					-				-				-
SP2:
SP3:
SP4:																					-																-				-				-
SP5:

ExUns:	14e	^	15a	·	15b	·	15c	·	15d	·	15e	^	16	^	17	^	18a	·	18b	^	19a	·	19b	^	20a	·	20b	·	20c	^	21	^	22a	·	22b	·	22c	·	22d	^	23a	·	23b	^	24	^	25	^	26a	·	26b	·
SP1:																			-		-		-		-								-		-		-		-				-						-
SP2:																																	-		-		-		-				-						-
SP3:																																											-						-
SP4:
SP5:																																	-										-						-

ExUns:	26c	^	27	^	28	^	29a	·	29b	^	30	^	31	^	32
SP1:									-
SP2:									-
SP3:									-
SP4:
SP5:

ECgene alternative splicing isoforms for UBAP2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBAP2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTCTGTGGG

About this image

UBAP2 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See UBAP2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for UBAP2

SOURCE GeneReport for Unigene cluster: Hs.493739

SABiosciences Custom PCR Arrays for UBAP2

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for UBAP2 gene from 6/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Ubap2^{1 , 5}	ubiquitin-associated protein 2^{1, 5}	84.79(n)¹ 82.21(a)¹		4 (21.13 cM)⁵ 68926¹ NM_026872.1¹ NP_081148.1¹ 41194313⁵
chicken (Gallus gallus)	Aves	LOC407092¹	AD012Z	75.25(n) 75.07(a)		407092 XM_003642921.1 XP_003642969.1
lizard (Anolis carolinensis)	Reptilia	UBAP2⁶	--	65(a)	1 ↔ 1	GL343372.1(803367-860939)
African clawed frog (Xenopus laevis)	Amphibia	Xl.33004²	Xenopus laevis transcribed sequence with weak similarity more	82.3(n)		CD363077.1
zebrafish (Danio rerio)	Actinopterygii	wufb19h07²	Transcribed sequence with weak similarity to protein more	81.82(n)		AI815368.1
fruit fly (Drosophila melanogaster)	Insecta	lig¹	lingerer	37.86(n) 29.53(a)		35771 NM_001014503.2 NP_001014503.1

ENSEMBL Gene Tree for UBAP2 (if available)
TreeFam Gene Tree for UBAP2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for UBAP2 gene

UBAP2L²

2 SIMAP similar genes for UBAP2 using alignment to 9 protein entries: UBAP2_HUMAN (see all proteins):

DKFZp781G1976 UBAP2L

UBAP2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11313948^1,2	C,	--	33907538(+)	`AGAGC-/TTAGAC`	1	--	int¹		0	--	--	--	--
rs141380123^1,2		--	33921303(+)	`TTCATA/GCTCTC`	1	--	ds500¹		0	--	--	--	--
rs186466180^1,2		--	33921584(+)	`GCCTTG/TATAGC`	1	--	ds500¹		0	--	--	--	--
rs150277070^1,2		--	33921629(+)	`TTTAGA/CCCTGT`	1	--	ds500¹		0	--	--	--	--
rs192535412^1,2		--	33921631(+)	`TAGCCC/TTGTGA`	1	--	ds500¹		0	--	--	--	--
rs72727329^1,2	C,F,	--	33921664(+)	`CTGCCC/ATTCAG`	1	--	ds500¹		1		NA	120
rs66460243^1,2	C,F	--	33921844(-)	`AAAAA-/ATAATC`	1	--	ut3¹		3		NA CSA	6
rs73492956^1,2	C,	--	33921907(+)	`CAGAAG/CCCCCT`	1	--	ut3¹		3		WA EA	240
rs11848^1,2	C,F,O,H,	--	33921919(-)	`TTCATA/GTAGAA`	1	--	ut3¹ ese³		23		MN NS EA NA	2474
rs2277178^1,2	C,F,H,	--	33921933(+)	`AAACAG/AGTGGC`	1	--	ut3¹ ese³		26		EA NA NS WA	4172

HapMap Linkage Disequilibrium report for UBAP2 (33921691 - 34048947 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for UBAP2
4 CNVs: 95940 82925 36949 95939

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing UBAP2

DNA2.0 Custom Variant and Variant Library Synthesis for UBAP2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

UBAP2 for disorders About GeneDecksing

1 disease for UBAP2: About MalaCards

aphasia

1 disease from the University of Copenhagen DISEASES database for UBAP2:

Aphasia

Human Genome Epidemiology (HuGE) Navigator: UBAP2 (1 document)

Export disorders for UBAP2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for UBAP2 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with UBAP2)

Utopia: connect your pdf to the dynamic
world of online information

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{1, 2} Humphray S.J.... Dunham I. (2004)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)^{1, 2} Brill L.M....Peters E.C. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10819331)^{1, 2} Nagase T.... Ohara O. (2000)
The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. (PubMed id 8871400)^{1, 3} Hofmann K. and Bucher P. (1996)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55833	HGNC: 14185	AceView: UBAP2	Ensembl:ENSG00000137073	euGenes: HUgn55833
ECgene: UBAP2	H-InvDB: UBAP2

(According to HUGE)
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HUGE: KIAA1491

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for UBAP2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for UBAP2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for UBAP2 gene:
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UBAP2 Gene

ubiquitin associated protein 2

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UBAP2 Gene

ubiquitin associated protein 2

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