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Aliases for UBAP1L Gene

Aliases for UBAP1L Gene

  • Ubiquitin Associated Protein 1 Like 2 3 5
  • UBAP-1L 3 4
  • Ubiquitin-Associated Protein 1-Like 3

External Ids for UBAP1L Gene

Previous GeneCards Identifiers for UBAP1L Gene

  • GC15M065387

Summaries for UBAP1L Gene

GeneCards Summary for UBAP1L Gene

UBAP1L (Ubiquitin Associated Protein 1 Like) is a Protein Coding gene. An important paralog of this gene is UBAP1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBAP1L Gene

Genomics for UBAP1L Gene

Regulatory Elements for UBAP1L Gene

Enhancers for UBAP1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F065053 1.2 Ensembl ENCODE 18.3 +60.0 60019 2.4 ELF3 PKNOX1 ARID4B SIN3A ZNF48 ZSCAN9 RAD21 YY1 SCRT2 ZNF143 UBAP1L SPG21 MTFMT KBTBD13 RASL12 RNU5B-1 RBPMS2 MIR1272 ENSG00000277351 PIR51727
GH15F065081 1.1 Ensembl ENCODE 18.6 +32.4 32399 2.8 CTCF KLF17 FEZF1 ZIC2 RAD21 ZNF121 ZFHX2 POLR2A PATZ1 SMC3 UBAP1L SPG21 MIR1272 KBTBD13 LOC105370862
GH15F065236 1.4 Ensembl ENCODE 12.9 -122.1 -122141 1.6 PKNOX1 ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 CBX5 KLF13 UBAP1L HACD3 IGDCC3 RNU6-686P ENSG00000206903
GH15F065056 1.3 Ensembl ENCODE 12.3 +58.0 57959 1.3 PKNOX1 MLX ARID4B SIN3A ZNF48 SLC30A9 FOS SP5 NFYC MIER2 SPG21 UBAP1L MTFMT RNU5B-1 RBPMS2 ENSG00000277351 PIR51727
GH15F065085 1.8 VISTA FANTOM5 Ensembl ENCODE 8.8 +27.1 27113 5.5 PKNOX1 ZFP64 DMAP1 FEZF1 ZNF48 YY1 ZNF121 GLIS2 ZNF263 SP3 MTFMT ZNF609 UBAP1L RASL12 LOC105370862 KBTBD13
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBAP1L on UCSC Golden Path with GeneCards custom track

Genomic Location for UBAP1L Gene

Chromosome:
15
Start:
65,092,760 bp from pter
End:
65,115,197 bp from pter
Size:
22,438 bases
Orientation:
Minus strand

Genomic View for UBAP1L Gene

Genes around UBAP1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBAP1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBAP1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBAP1L Gene

Proteins for UBAP1L Gene

  • Protein details for UBAP1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    F5GYI3-UBA1L_HUMAN
    Recommended name:
    Ubiquitin-associated protein 1-like
    Protein Accession:
    F5GYI3

    Protein attributes for UBAP1L Gene

    Size:
    381 amino acids
    Molecular mass:
    40592 Da
    Quaternary structure:
    No Data Available

neXtProt entry for UBAP1L Gene

Post-translational modifications for UBAP1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for UBAP1L Gene

No data available for DME Specific Peptides for UBAP1L Gene

Domains & Families for UBAP1L Gene

Protein Domains for UBAP1L Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

F5GYI3

UniProtKB/Swiss-Prot:

UBA1L_HUMAN :
  • Contains 1 UMA domain.
Domain:
  • Contains 1 UMA domain.
genes like me logo Genes that share domains with UBAP1L: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for UBAP1L Gene

Function for UBAP1L Gene

Gene Ontology (GO) - Molecular Function for UBAP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043130 ubiquitin binding IBA --
genes like me logo Genes that share ontologies with UBAP1L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for UBAP1L Gene

Localization for UBAP1L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBAP1L gene
Compartment Confidence
endosome 3

Gene Ontology (GO) - Cellular Components for UBAP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000813 ESCRT I complex IBA --
genes like me logo Genes that share ontologies with UBAP1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for UBAP1L Gene

Pathways & Interactions for UBAP1L Gene

SuperPathways for UBAP1L Gene

No Data Available

Interacting Proteins for UBAP1L Gene

Gene Ontology (GO) - Biological Process for UBAP1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA --
genes like me logo Genes that share ontologies with UBAP1L: view

No data available for Pathways by source and SIGNOR curated interactions for UBAP1L Gene

Transcripts for UBAP1L Gene

Unigene Clusters for UBAP1L Gene

Ubiquitin associated protein 1-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBAP1L Gene

No ASD Table

Relevant External Links for UBAP1L Gene

GeneLoc Exon Structure for
UBAP1L
ECgene alternative splicing isoforms for
UBAP1L

Expression for UBAP1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for UBAP1L Gene

mRNA differential expression in normal tissues according to GTEx for UBAP1L Gene

This gene is overexpressed in Brain - Cerebellum (x5.0) and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for UBAP1L Gene

This gene is overexpressed in Ovary (28.7), Adrenal (15.7), and Gallbladder (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UBAP1L Gene



Protein tissue co-expression partners for UBAP1L Gene

NURSA nuclear receptor signaling pathways regulating expression of UBAP1L Gene:

UBAP1L

SOURCE GeneReport for Unigene cluster for UBAP1L Gene:

Hs.659256
genes like me logo Genes that share expression patterns with UBAP1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for UBAP1L Gene

Orthologs for UBAP1L Gene

This gene was present in the common ancestor of chordates.

Orthologs for UBAP1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia UBAP1L 34 35
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia UBAP1L 34 35
  • 83.02 (n)
cow
(Bos Taurus)
Mammalia UBAP1L 34
  • 79.95 (n)
rat
(Rattus norvegicus)
Mammalia Ubap1l 34
  • 78.08 (n)
mouse
(Mus musculus)
Mammalia Gm514 34 35
  • 75.57 (n)
Ubap1l 16
oppossum
(Monodelphis domestica)
Mammalia UBAP1L 35
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 13 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PDCD7 34
  • 60.43 (n)
UBAP1L 35
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBAP1L 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ubap1l 34
  • 53.19 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01068819.1 35
  • 29 (a)
OneToMany
UBAP1L (1 of 2) 35
  • 29 (a)
OneToMany
Species where no ortholog for UBAP1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBAP1L Gene

ENSEMBL:
Gene Tree for UBAP1L (if available)
TreeFam:
Gene Tree for UBAP1L (if available)

Paralogs for UBAP1L Gene

Paralogs for UBAP1L Gene

genes like me logo Genes that share paralogs with UBAP1L: view

Variants for UBAP1L Gene

Sequence variations from dbSNP and Humsavar for UBAP1L Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10626883 -- 65,092,390(+) CAGAT(-/AGTC)AGAGC downstream-variant-500B, upstream-variant-2KB
rs111513349 -- 65,104,301(+) GAGAG(A/C)GAGAC intron-variant
rs111577532 -- 65,096,512(+) AGCCC(C/T)GAGAG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111875132 -- 65,104,336(+) GAAGA(A/G)AAGAA intron-variant
rs111881195 -- 65,105,794(+) AAGAG(C/T)GCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBAP1L Gene

Variant ID Type Subtype PubMed ID
esv2763104 CNV gain 21179565
nsv1570 CNV insertion 18451855
nsv984085 CNV duplication 23825009

Variation tolerance for UBAP1L Gene

Gene Damage Index Score: 2.42; 42.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBAP1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBAP1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBAP1L Gene

Disorders for UBAP1L Gene

Relevant External Links for UBAP1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBAP1L

No disorders were found for UBAP1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBAP1L Gene

Publications for UBAP1L Gene

  1. UMA and MABP domains throw light on receptor endocytosis and selection of endosomal cargoes. (PMID: 20448139) de Souza R.F. … Aravind L. (Bioinformatics 2010) 3 64
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for UBAP1L Gene

Sources for UBAP1L Gene

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