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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

UBAP1L Gene

protein-coding   GIFtS: 30
GCID: GC15M065387

Ubiquitin Associated Protein 1-Like

  Search for UBAP1L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ubiquitin Associated Protein 1-Like1 2
UBAP-1L2 3
Ubiquitin-Associated Protein 1-Like2

External Ids:    HGNC: 400281   Entrez Gene: 3905952   Ensembl: ENSG000002469227   UniProtKB: F5GYI33   

Export aliases for UBAP1L gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for UBAP1L Gene: 
UBAP1L (ubiquitin associated protein 1-like) is a protein-coding gene. An important paralog of this gene is UBAP1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for UBAP1L
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for UBAP1L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat UBAP1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.31

UBAP1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
UBAP1L gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M065387:  view genomic region     (about GC identifiers)

Start:
65,385,338 bp from pter      End:
65,407,535 bp from pter
Size:
22,198 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: UBA1L_HUMAN, F5GYI3 (See protein sequence)
Recommended Name: Ubiquitin-associated protein 1-like  
Size: 381 amino acids; 40592 Da

Explore the universe of human proteins at neXtProt for UBAP1L: NX_F5GYI3

UBAP1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001157164.1  
ENSEMBL proteins: 
 ENSP00000454012   ENSP00000452794   ENSP00000440243  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR023340 UMA

Graphical View of Domain Structure for InterPro Entry F5GYI3

ProtoNet protein and cluster: F5GYI3

UniProtKB/Swiss-Prot: UBA1L_HUMAN, F5GYI3
Similarity: Contains 1 UMA domain


UBAP1L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
UBAP1L for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for UBAP1L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for UBAP1L (UBA1L)

Search CenterWatch for drugs/clinical trials and news about UBAP1L / UBA1L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for UBAP1L gene: 
NM_001163692.1  

Unigene Cluster for UBAP1L:

Ubiquitin associated protein 1-like
Hs.659256  [show with all ESTs]
Unigene Representative Sequence: AL359606
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000559089(uc010bhe.3 uc010uit.2 uc002aok.3 uc010bhf.1)
ENST00000561387 ENST00000558802 ENST00000502113
miRNA
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Additional mRNA sequence: 

AL359606.1 BC127916.1 

5 DOTS entries:

DT.119885  DT.97835564  DT.97836051  DT.100021691  DT.121025624 

24/55 AceView cDNA sequences (see all 55):

BQ447800 BQ638568 BQ183317 BQ639549 AI096917 BX499586 CA390048 BM665211 
BU726554 AI805991 BU730110 AI554748 BM703685 AL359606 AA323443 BQ694448 
BF765184 BQ677048 AL707536 BM665490 AU140509 CR749500 BX098619 BU168199 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

UBAP1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAACCGCCG
UBAP1L Expression
About this image


Genevestigator expression for UBAP1L

SOURCE GeneReport for Unigene cluster: Hs.659256
    SABiosciences Custom PCR Arrays for UBAP1L
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for UBAP1L gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm5141 , 5 predicted gene 5141, 5 76.34(n)1
72.93(a)1
  9 (35.26 cM)5
2080801  NM_001111145.11  NP_001104615.11 
 653610605 
chicken
(Gallus gallus)
Aves UBAP1L1 ubiquitin associated protein 1-like 56.17(n)
47.4(a)
  769261  XM_001232496.1  XP_001232497.1 
lizard
(Anolis carolinensis)
Reptilia UBAP1L6
Uncharacterized protein
72(a)
1 ↔ 1
GL343392.1(282285-284652)
zebrafish
(Danio rerio)
Actinopterygii LOC1000045901 uncharacterized LOC100004590 51.04(n)
41.81(a)
  100004590  XM_001343816.1  XP_001343852.1 


ENSEMBL Gene Tree for UBAP1L (if available)
TreeFam Gene Tree for UBAP1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for UBAP1L gene
UBAP12  

UBAP1L for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/243 SNPs in UBAP1L are shown (see all 243)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs792049931,2
C--65385214(+) ATAGCC/TCCCCG 1 -- int10--------
rs758685391,2
C--65385219(+) TCCCCA/GTCCGG 1 -- int10--------
rs789011871,2
C--65385220(+) CCCCGA/TCCGGC 1 -- int10--------
rs800944641,2
C,F--65385229(+) GCTCTC/TCCATC 1 -- int11Minor allele frequency- T:0.01WA 118
rs783969171,2
C,F--65385304(+) CTTGGT/CATTAT 1 -- int11Minor allele frequency- C:0.03NA 120
rs1126161451,2
C--65385323(+) TTACAA/GTAAGT 1 -- int12Minor allele frequency- G:0.04CSA WA 120
rs1900507331,2
--65385443(+) CTGGGC/TACAGG 2 T A mis10--------
rs1813395931,2
--65385464(+) CTCCAA/GGGCTT 2 L syn10--------
rs1461106931,2
C--65385511(+) TGATCC/TGGTCC 2 Q R mis10--------
rs1858035661,2
--65385673(+) AAAGCC/TGTGGC 1 -- int10--------

HapMap Linkage Disequilibrium report for UBAP1L (65385338 - 65407535 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for UBAP1L:    About this table     
Variant IDTypeSubtypePubMed ID
nsv1570CNV Insertion18451855
nsv904308CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for UBAP1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with UBAP1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 390595 HGNC: 40028 AceView: LOC390595 Ensembl:ENSG00000246922 euGenes: HUgn390595
ECgene: UBAP1L H-InvDB: UBAP1L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for UBAP1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for UBAP1L gene:
Search GeneIP for patents involving UBAP1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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